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https://www.readbyqxmd.com/read/28453725/serelaxin-treatment-promotes-adaptive-hypertrophy-but-does-not-prevent-heart-failure-in-experimental-peripartum-cardiomyopathy
#1
Justus Nonhoff, Melanie Ricke-Hoch, Mirco Mueller, Britta Stapel, Tobias Pfeffer, Martina Kasten, Michaela Scherr, Constantin von Kaisenberg, Johann Bauersachs, Arash Haghikia, Denise Hilfiker-Kleiner
Aims: Peripartum cardiomyopathy (PPCM) is a systolic left ventricular dysfunction developing in the peripartum phase in previously healthy women. Relaxin-2 is a pregnancy hormone with potential beneficial effects in heart failure patients. We evaluated Relaxin-2 as a potential diagnostic marker and/or a therapeutic agent in PPCM. Methods and results: In healthy peripartum women, serum Relaxin-2 levels (measured by ELISA in the second half of pregnancy) were elevated showing a decreasing trend in the first postpartum week and returned to non-pregnant levels thereafter...
May 1, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28453363/a-polyphenol-based-multicomponent-nutraceutical-in-dysmetabolism-and-oxidative-stress-results-from-a-pilot-study
#2
Roberto Corsi, Giovanni Mosti, Attilio Cavezzi, Simone Ugo Urso, Gayla Dimitrova, Elena Fioroni, Roberto Colucci, Valentina Quinzi
To assess short-term efficacy and safety of a multicomponent nutraceutical (MCN) on dysmetabolism and oxidative stress, a pilot prospective observational study was performed on 21 individuals (12 men and 9 women) who took, for 60 days, 2 tablets per day of an MCN based on antioxidants and metabolism regulators: hydroxytyrosol (15 mg), maqui (300 mg), amla (200 mg), monacolin K (10 mg), berberine (245 mg), astaxanthin (0.5 mg), coenzyme Q10 (100 mg), and folic acid (200 mcg). On day 0 (T0) and day 60 (T60), all participants underwent laboratory tests related to lipid profile, carbohydrate metabolism, oxidative stress, and cellular inflammation...
April 28, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28449461/correlation-of-pleural-effusions-grayscale-sonographic-parameters-with-fluid-s-analysis-results
#3
Alexandros Kalkanis, Charalampos Varsamas, Konstantinos Gourgoulianis
BACKGROUND: Quantitative sonographic methods are used to assess pleural fluid's volume but no validated method exists for the measurement of the fluids' density and other qualitative values. We suggest a quantitative method, based on the pixel density of the pleural effusion's image, in order to evaluate the echogenicity of pleural effusion. METHODS: Pleural ultrasound (US) was performed in 62 patients with pleural effusion. Five consequent images of the pleural effusion were retrieved through axial view between the 9(th) and the 10(th) rib and one from the 10(th) rib through coronal view and converted into the high-resolution tagged image file format...
March 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28449421/-the-role-of-micrornas-in-colorectal-cancer
#4
REVIEW
Sang Wook Kim
Colorectal cancer (CRC) is one of the leading causes of cancer related deaths in the world. Many oncogenes and tumor suppressor genes are involved in the development of CRC. MicroRNAs (miRNAs) are a class of small, non-coding, endogenous RNAs in animals and plants. Recent studies have shown that miRNAs are associated with the mediation process of tumorigenesis, including inflammation, cell cycle, stress response, differentiation, apoptosis, migration, and invasion in cancer. These miRNAs have been linked to the development of CRC and recently studied as new potential biomarkers in the diagnosis and treatment for CRC...
April 25, 2017: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/28448237/regulatory-t-cell-therapy-for-uveitis-a-new-promising-challenge
#5
Arnaud Foussat, Sylvie Gregoire, Nathalie Clerget-Chossat, Celine Terrada, Hélène Asnagli, François M Lemoine, David Klatzmann, Phuc LeHoang, Miguel Forte, Bahram Bodaghi
Uveitis is a sight-threatening primary intraocular inflammation of various origins in mainly young and active patients. Due to the absence of biomarkers in most of the cases, the current treatment of noninfectious entities remains nonspecific, using corticosteroids, conventional immunosuppressors, and more recently biological agents. Identification of regulatory T cells in different models of autoimmune uveitis together with the evaluation of this important subpopulation in different entities paved the way for new therapeutic strategies, in addition to exclusive pharmaceutical approaches...
May 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28448210/body-composition-and-inflammatory-markers-in-pubertal-girls-comparison-between-athletes-and-non-athletic-controls
#6
Jaak Jürimäe, Kristel Võsoberg, Anna-Liisa Tamm, Katre Maasalu, Liina Remmel, Vallo Tillmann
Various inflammation parameters are increased with childhood obesity, but few comparable data are found in lean growing athletes. This study aims to characterize differences in 12 simultaneously measured inflammatory parameters between pubertal rhythmic gymnasts (RG) and untrained controls (UC), and to examine the relationship between body composition and inflammatory markers. Sixty 10-12-year-old girls were divided into RG (n = 30) and UC (n = 30). Fat mass (FM) and fat free mass (FFM) were measured by dual-energy X-ray absorptiometry...
April 27, 2017: European Journal of Sport Science
https://www.readbyqxmd.com/read/28447072/a-randomized-trial-of-the-effects-of-the-no-carrageenan-diet-on-ulcerative-colitis-disease-activity
#7
Sumit Bhattacharyya, Theresa Shumard, Hui Xie, Amar Dodda, Krista A Varady, Leo Feferman, Allan G Halline, Jay L Goldstein, Stephen B Hanauer, Joanne K Tobacman
BACKGROUND: Carrageenan is a very common food additive in Western diets, but predictably causes inflammation in thousands of cell-based and animal experiments. OBJECTIVE: To assess the impact of carrageenan exposure on the interval to relapse in patients with ulcerative colitis in remission. METHODS: A randomized, double-blind, placebo-controlled, multicenter, clinical trial was conducted to assess if patients with ulcerative colitis in remission would have a longer interval to relapse if they followed a diet with no carrageenan...
March 31, 2017: Nutrition and Healthy Aging
https://www.readbyqxmd.com/read/28446628/plasma-ferritin-and-hepcidin-are-lower-at-4-months-postpartum-among-women-with-elevated-c-reactive-protein-or-%C3%AE-1-acid-glycoprotein
#8
Josh M Jorgensen, Zhenyu Yang, Bo Lönnerdal, Caroline J Chantry, Kathryn G Dewey
Background: Ferritin and hepcidin are markers of iron status that typically increase during inflammation or infection. The postpartum period is a physiologically unique life stage in which the relations between these proteins and other markers of inflammation have not been extensively studied.Objective: We aimed to determine whether 2 markers of inflammation [high-sensitivity C-reactive protein (CRP) and α1-acid glycoprotein (AGP)] were associated with ferritin or hepcidin in postpartum women in California...
April 26, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28446517/a-novel-%C3%AE-calcitonin-gene-related-peptide-analogue-protects-against-end-organ-damage-in-experimental-hypertension-cardiac-hypertrophy-and-heart-failure
#9
Aisah A Aubdool, Pratish Thakore, Fulye Argunhan, Sarah-Jane Smillie, Moritz Schnelle, Salil Srivastava, Khadija M Alawi, Elena Wilde, Jennifer Mitchell, Keith Farrell-Dillon, Daniel A Richards, Giuseppe Maltese, Richard C Siow, Manasi Nandi, James E Clark, Ajay M Shah, Anette Sams, Susan D Brain
Background -Research into the therapeutic potential of α-calcitonin gene-related peptide (α-CGRP) has been limited due to its peptide nature and short half-life. Here, we evaluate whether a novel potent and long lasting (t½ ≥ 7h) acylated α-CGRP analogue (αAnalogue) could alleviate and reverse cardiovascular disease in two distinct murine models of hypertension and heart failure in vivoMethods -The ability of the αAnalogue to act selectively via the CGRP pathway was shown in skin using a CGRP receptor antagonist...
April 26, 2017: Circulation
https://www.readbyqxmd.com/read/28445689/clinical-staging-and-serum-cytokines-in-bipolar-patients-during-euthymia
#10
Amparo Tatay-Manteiga, Vicent Balanzá-Martínez, Giovana Bristot, Rafael Tabarés-Seisdedos, Flavio Kapczinski, Omar Cauli
AIMS: Changes in serum cytokines and altered neutrophin concentration have been associated with bipolar disorder (BD). Our aim here was to analyze peripheral blood biomarkers according to the clinical stages of BD. METHOD: Euthymic BD-I patients were grouped according to their level of functioning in early-stage (n=25) and late-stage (n=23), and compared to healthy siblings (n=23) and genetically unrelated healthy controls (n=21). Neurotrophin (neurotrophin-3 and BDNF) concentration and biomarkers of inflammation, including cytokines (IL-6, IL-10 and TNF-α), leukocytes countand acute phase proteins, were measured...
April 23, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28444928/antiinflammatory-activity-of-cinnamon-cinnamomum-zeylanicum-bark-essential-oil-in-a-human-skin-disease-model
#11
Xuesheng Han, Tory L Parker
The effect of cinnamon (Cinnamomum zeylanicum) bark essential oil (CBEO) on human skin cells has not been elucidated. Therefore, we investigated the activity of a commercially available CBEO in a validated human dermal fibroblast system, a model of chronic inflammation and fibrosis. We first evaluated the impact of CBEO on 17 protein biomarkers that play critical roles in inflammation and tissue remodeling. The impact of CBEO on genome-wide gene expression was also evaluated. CBEO showed strong anti-proliferative effects on skin cells and significantly inhibited the production of several inflammatory biomarkers, including vascular cell adhesion molecule-1, intercellular cell adhesion molecule-1, monocyte chemoattractant protein-1, interferon gamma-induced protein 10, interferon-inducible T-cell alpha chemoattractant, and monokine induced by gamma interferon...
April 26, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28444548/post-effect-of-air-quality-improvement-on-biomarkers-for-systemic-inflammation-and-microparticles-in-asthma-patients-after-the-2008-beijing-olympic-games-a-pilot-study
#12
Jinming Gao, Xiaohua Xu, Zhekang Ying, Lei Jiang, Mianhua Zhong, Aixia Wang, Lung-Chi Chen, Bo Lu, Qinghua Sun
This study's aim was to investigate the post-effect of an air quality improvement on systemic inflammation and circulating microparticles in asthmatic patients during, and 2 months after, the Beijing Olympics 2008. We measured the levels of circulating inflammatory cytokines and microparticles in the peripheral blood from asthma patients and healthy controls during (phase 1), and 2 months after (phase 2) the Beijing 2008 Olympic Games. The concentrations of circulating cytokines (including TNFα, IL-6, IL-8, and IL-10) were still seen reduced in phase 2 when compared with those in phase 1...
April 25, 2017: Inflammation
https://www.readbyqxmd.com/read/28443095/radiotherapy-associated-long-term-modification-of-expression-of-the-inflammatory-biomarker-genes-arg1-bcl2l1-and-myc
#13
Grainne Manning, Aleš Tichý, Igor Sirák, Christophe Badie
Ionizing radiation (IR) exposure of cells in vitro and in vivo triggers a complex cellular response among which modifications of gene expression have been consistently reported. Nevertheless, little is currently known about the transcriptionally responsive genes which play a role in the inflammation response. In order to improve our understanding of such transcriptional response to radiation in vivo, we simultaneously monitored the expression of 249 genes associated with the inflammation response over the course of the radiotherapy treatment in blood of patients treated for endometrial or head and neck cancer...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28442699/does-the-rapid-fecal-calprotectin-test-equally-predict-mucosal-inflammation-in-both-ulcerative-colitis-uc-and-crohn-s-disease-cd-a-prospective-analysis-of-an-ibd-cohort
#14
Andrzej Moniuszko, Stanisław Głuszek, Grażyna Rydzewska
INTRODUCTION    Fecal calprotectin (FC) is a well-established biomarker of intestinal inflammation in CD and UC. However, standard laboratory methods are time consuming and not always useful in clinical practice.  OBJECTIVES    We analyzed the efficacy of a rapid bedside FC test to detect disease flares in a hospital setting. We also assessed the influence of disease location on diagnostic accuracy. PATIENTS AND METHODS    140 patients were prospectively enrolled in the study (46 UC, 94 CD). FC was measured both by ELISA and by the rapid Quantum Blue® test...
April 26, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/28442511/circulating-mirna-profiles-of-doxorubicin-induced-cardiotoxicity-in-breast-cancer-patients
#15
Valentina K Todorova, Issam Makhoul, Jeanne Wei, V S Klimberg
Doxorubicin (DOX) cardiotoxicity is unpredictable and begins with the first dose of chemotherapy. This study aimed to obtain information about circulating microRNA of cancer patients in the early dose of DOX chemotherapy, who either did or did not develop cardiac abnormality after the completion of chemotherapy. Plasma of 20 patients treated for breast cancer with DOX-chemotherapy was analyzed using quantitative RT-PCR. Circulating microRNA profiles of patients with DOX cardiotoxicity were compared to microRNA profiles of patients without DOX cardiotoxicity by quantitative real-time PCR...
March 2017: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/28442299/the-anti-inflammatory-function-of-high-density-lipoprotein-in-type-ii-diabetes-a-systematic-review
#16
Roosmarijn F H Lemmers, Mandy van Hoek, Aloysius G Lieverse, Adrie J M Verhoeven, Eric J G Sijbrands, Monique T Mulder
BACKGROUND: Inflammation is a pathophysiological factor in diabetes and its cardiovascular complications. High-density lipoprotein (HDL) suppresses inflammation in healthy individuals. The relationship of HDL with diabetes and cardiovascular disease may be explained by HDL function rather than by HDL cholesterol level. In diabetes, HDL seems to become dysfunctional. OBJECTIVE: We performed a systematic review to answer the following research questions: Is the anti-inflammatory function of HDL diminished in individuals with diabetes and if so, what causes this? METHODS: We systematically searched Medline and Embase and included original research articles on the anti-inflammatory effects of HDL or HDL-based interventions in diabetes or diabetes models...
March 31, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28441998/25-hydroxyvitamin-d-biomarkers-of-eosinophilic-inflammation-and-airway-remodeling-in-children-with-newly-diagnosed-untreated-asthma
#17
G Sypniewska, M Krintus, G Fulgheri, J Siodmiak, M Kuligowska-Prusinska, B Stepien-Jaszowska, R Staszak-Kowalska, A Zawadzka-Krajewska, S Kierat, K Bergmann, U Demkow
No abstract text is available yet for this article.
May 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28441982/25-hydroxyvitamin-d-biomarkers-of-eosinophilic-inflammation-and-airway-remodeling-in-children-with-newly-diagnosed-untreated-asthma
#18
Grazyna Sypniewska, Magdalena Krintus, Gabriele Fulgheri, Joanna Siodmiak, Magdalena Kuligowska-Prusinska, Beata Stepien-Jaszowska, Radosława Staszak-Kowalska, Anna Zawadzka-Krajewska, Szymon Kierat, Katarzyna Bergmann, Urszula Demkow
BACKGROUND: Low 25-hydroxyvitamin D (25[OH]D) and asthma development may be related to airway remodeling and eosinophilia. Periostin is proposed as a key molecule that links remodeling and eosinophilic inflammation. OBJECTIVE: We evaluated the association of 25(OH)D concentration with periostin, peripheral blood eosinophil counts, and immunoglobulin E (IgE) in children with newly diagnosed asthma. METHODS: The study included 150 children: 110 with atopic asthma and 40 constituted a reference group...
May 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28441964/fecal-metagenomic-profiles-in-subgroups-of-patients-with-myalgic-encephalomyelitis-chronic-fatigue-syndrome
#19
Dorottya Nagy-Szakal, Brent L Williams, Nischay Mishra, Xiaoyu Che, Bohyun Lee, Lucinda Bateman, Nancy G Klimas, Anthony L Komaroff, Susan Levine, Jose G Montoya, Daniel L Peterson, Devi Ramanan, Komal Jain, Meredith L Eddy, Mady Hornig, W Ian Lipkin
BACKGROUND: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is characterized by unexplained persistent fatigue, commonly accompanied by cognitive dysfunction, sleeping disturbances, orthostatic intolerance, fever, lymphadenopathy, and irritable bowel syndrome (IBS). The extent to which the gastrointestinal microbiome and peripheral inflammation are associated with ME/CFS remains unclear. We pursued rigorous clinical characterization, fecal bacterial metagenomics, and plasma immune molecule analyses in 50 ME/CFS patients and 50 healthy controls frequency-matched for age, sex, race/ethnicity, geographic site, and season of sampling...
April 26, 2017: Microbiome
https://www.readbyqxmd.com/read/28441923/lowered-pon1-activities-are-strongly-associated-with-depression-and-bipolar-disorder-recurrence-of-hypo-mania-and-depression-increased-disability-and-lowered-quality-of-life
#20
Estefania Gastaldello Moreira, Dalmo Guilherme Correia, Kamila Landucci Bonifácio, Juliana Brum de Moraes, Fernanda Liboni Cavicchioli, Carolina Sampaio Nunes, Sandra Odebrecht Vargas Nunes, Heber Odebrecht Vargas, Décio Sabbatini Barbosa, Michael Maes
BACKGROUND: Mood disorders (MD) frequently co-exist with cardiovascular disease (CVD) and immune-inflammatory and oxidative stress are important shared pathophysiological pathways. Even though there is an extensive investigation of the enzyme paraoxonase 1 (PON1) as a biomarker of susceptibility for CVD, there are only few reports studying PON1 in MD. OBJECTIVES: To determine the association between PON1 activities as well as functional genotypes and MD diagnosis, clinical characteristics and outcomes...
April 26, 2017: World Journal of Biological Psychiatry
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