keyword
MENU ▼
Read by QxMD icon Read
search

inflammation biomarkers

keyword
https://www.readbyqxmd.com/read/29791507/a-novel-mouse-model-of-campylobacter-jejuni-enteropathy-and-diarrhea
#1
Natasa Giallourou, Gregory L Medlock, David T Bolick, Pedro Hqs Medeiros, Solanka E Ledwaba, Glynis L Kolling, Kenneth Tung, Patricia Guerry, Jonathan R Swann, Richard L Guerrant
Campylobacter infections are among the leading bacterial causes of diarrhea and of 'environmental enteropathy' (EE) and growth failure worldwide. However, the lack of an inexpensive small animal model of enteric disease with Campylobacter has been a major limitation for understanding its pathogenesis, interventions or vaccine development. We describe a robust standard mouse model that can exhibit reproducible bloody diarrhea or growth failure, depending on the zinc or protein deficient diet and on antibiotic alteration of normal microbiota prior to infection...
May 23, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29791130/quantification-of-serum-high-mobility-group-box-1-by-liquid-chromatography-high-resolution-mass-spectrometry-implications-for-its-role-in-immunity-inflammation-and-cancer
#2
Liwei Weng, Lili Guo, Anil Vachani, Clementina A Mesaros, Ian Alexander Blair
High mobility group box 1 (HMGB1), is a non-histone chromosomal protein, which can be secreted through a variety of pathways and bind to pattern recognition receptors to release pro-inflammatory cytokines. Previous studies have suggested that HMGB1 is up-regulated in numerous inflammatory diseases and that it could be a biomarker for such diseases. However, these studies used immunoassay-based methods to analyze serum HMGB1. Autoantibodies to HMGB1 in serum are found in healthy control subjects as well as in patients with different diseases...
May 23, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29790215/attenuated-nitric-oxide-bioavailability-in-systemic-sclerosis-evidence-from-the-novel-assessment-of-passive-leg-movement
#3
Heather L Clifton, Daniel R Machin, H Jonathan Groot, Tracy M Frech, Anthony J Donato, Russell S Richardson, D Walter Wray
NEW FINDINGS: What is the central question of this study? Do systemic sclerosis (SSc) patients exhibit impaired nitric oxide (NO)-mediated vascular function of the lower limb, and are these decrements correlated with plasma biomarkers for inflammation and oxidative stress? What is the main finding and its importance? Findings indicate impaired NO-mediated vascular function, linked to the incidence of digital ulcers, and a milieu of inflammation and oxidative stress. However, the absence of significant correlations between individual biomarkers and blood flow responses suggests the vasculopathy observed in SSc may not be solely the result of derangements in the redox balance or inflammatory signaling...
May 23, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29789624/interplay-between-gut-microbiota-metabolism-and-inflammation-in-hiv-infection
#4
EDITORIAL
Jorge F Vázquez-Castellanos, Sergio Serrano-Villar, Nuria Jiménez-Hernández, María Dolores Soto Del Rio, Sara Gayo, David Rojo, Manuel Ferrer, Coral Barbas, Santiago Moreno, Vicente Estrada, Tomas Rattei, Amparo Latorre, Andrés Moya, María José Gosalbes
HIV infection causes a disruption of gut-associated lymphoid tissue, driving a shift in the composition of gut microbiota. A deeper understanding of the metabolic changes and how they affect the interplay with the host is needed. Here, we assessed functional modifications of HIV-associated microbiota by combining metagenomic and metatranscriptomic analyses. The transcriptionally active microbiota was well-adapted to the inflamed environment, overexpressing pathways related to resistance to oxidative stress...
May 23, 2018: ISME Journal
https://www.readbyqxmd.com/read/29788800/relationship-between-ykl-40-and-pulmonary-arterial-hypertension-in-systemic-sclerosis
#5
Tetsuya Furukawa, Kiyoshi Matsui, Masayasu Kitano, Yuichi Yokoyama, Masahiro Sekiguchi, Naoto Azuma, Yasutomo Imai, Seiichi Hirota, Kiyofumi Yamanishi, Hajime Sano
OBJECTIVES: Systemic sclerosis (SSc) is an intractable connective tissue disease that causes skin and organ fibrosis. Interstitial lung disease (ILD) and pulmonary arterial hypertension (PAH) affect its prognosis. YKL-40 protein impacts inflammation and tissue remodeling. Therefore, we evaluated the utility of YKL-40 blood levels in identifying patients with SSc complicated by PAH, as confirmed by immunohistochemistry (IHC) examination. METHODS: We retrospectively analyzed 78 patients with SSc and performed IHC on 7 normal and 7 SSc skin samples in the Japanese population...
May 23, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29788156/systemic-inflammation-markers-after-simplification-to-atazanavir-ritonavir-plus-lamivudine-in-virologically-suppressed-hiv-1-infected-patients-atlas-m-substudy
#6
Simone Belmonti, Francesca Lombardi, Eugenia Quiros-Roldan, Alessandra Latini, Antonella Castagna, Alberto Borghetti, Gianmaria Baldin, Arturo Ciccullo, Roberto Cauda, Andrea De Luca, Simona Di Giambenedetto
Background: Biomarkers of systemic inflammation predict non-AIDS events and overall mortality in virologically suppressed HIV-1-infected patients. Objectives: To determine whether switching to a dual antiretroviral maintenance therapy was associated with modification of biomarkers of systemic inflammation as compared with continuation of successful standard triple therapy. Methods: In this substudy of the randomized ATLAS-M trial, we compared in virologically suppressed patients the impact at 1 year of simplification to a dual therapy with atazanavir/ritonavir plus lamivudine versus maintaining atazanavir/ritonavir plus two NRTI triple therapy on markers of systemic inflammation...
April 17, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29788075/effects-of-immunonutrition-in-advanced-hiv-disease-a-randomized-placebo-controlled-clinical-trial-promaltia-study
#7
Sergio Serrano-Villar, María de Lagarde, Jorge Vázquez-Castellanos, Alejandro Vallejo, J Ignacio Bernadino, Nadia Madrid, Mariano Matarranz, Alberto Díaz-Santiago, Carolina Gutiérrez, Alfonso Cabello, Judit Villar-García, José Ramón Blanco, Otilia Bisbal, Talía Sainz, Andrés Moya, Santiago Moreno, María José Gosalbes, Vicente Estrada
Background: While nutritional interventions with prebiotics and probiotics seem to exert immunological effects, their clinical implications in HIV-infected subjects initiating ART at advanced HIV disease remain unclear. Methodology: Pilot multicenter randomized, placebo-controlled, double-blind study in which 78 HIV-infected, ART-naive subjects with <350 CD4 T-cells/µl or AIDS were randomized to either daily PMT25341 (a mixture of prebiotics, probiotics, oligonutrients, DHA, EPA, GLA, and aminoacids) or placebo for 48 weeks, each in combination with first-line ART...
May 16, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29787856/the-association-of-disease-activity-pro-inflammatory-cytokines-and-neurotrophic-factors-with-depression-in-patients-with-rheumatoid-arthritis
#8
Yun-Hong Cheon, Seung-Geun Lee, Mingyo Kim, Hyun-Ok Kim, Young Sun Suh, Ki-Soo Park, Rock Bum Kim, Hyun-Su Yang, Ji-Min Kim, Chang-Nam Son, Eun Kyoung Park, Sang-Hyon Kim, Sang-Il Lee
Inflammation and trophic factors (brain-derived neurotrophic factor [BDNF], vascular endothelial growth factor, glial cell line-derived neurotrophic factor, and insulin-like growth factor-1) are associated with depression in the general population. Rheumatoid arthritis (RA) is a chronic representative inflammatory autoimmune disease; however, the association of disease activity, pro-inflammatory cytokines, and neurotrophic factors with depression has not been sufficiently investigated. Therefore, we determined the prevalence of depression and risk factors for depression and deterioration of depressive symptoms in RA patients...
May 19, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29787423/autoimmune-granulomatous-inflammation-of-lacrimal-glands-and-axonal-neuritis-following-treatment-with-ipilimumab-and-radiation-therapy
#9
Ecaterina Ileana Dumbrava, Veronica Smith, Rasha Alfattal, Adel K El-Naggar, Marta Penas-Prado, Apostolia M Tsimberidou
Immune checkpoint inhibitors such as anti-CTLA-4 (cytotoxic T-lymphocyte-associated protein 4), anti PD-1 (programmed cell death protein 1) and PD-L1 (programmed cell death protein-ligand 1) monoclonal antibodies are emerging as standard oncology treatments in various tumor types. The indications will expand as immunotherapies are being investigated in various tumors with promising results. Currently, there is inadequate identification of predictive biomarkers of response or toxicity. Unique response patterns include pseudoprogression and delayed response...
May 21, 2018: Journal of Immunotherapy
https://www.readbyqxmd.com/read/29785410/relationship-of-hs-crp-and-sacroiliac-joint-inflammation-in-undifferentiated-spondyloarthritis
#10
Te-Jung Liu, Cheng-Chiang Chang, Liang-Cheng Chen, Heng-Yi Chu, Chun-Sheng Hsu, Shin-Tsu Chang
Objective: Elevation of serum high sensitivity C-reactive protein (hs-CRP) level has been demonstrated as a risk factor for varying diseases, as well as a biomarker for predicting recovery after operation of lumber disc herniation. Our objective was to investigate the relationship between serum hs-CRP and sacroiliac (SI) joint inflammation in patients with undifferentiated spondyloarthritis (uSpA). Methods: In this retrospective study, we enrolled patients with uSpA who underwent hs-CRP testing between January 2007 and September 2013...
2018: Open Medicine (Warsaw, Poland)
https://www.readbyqxmd.com/read/29785401/rheumatoid-arthritis-and-mirnas-a-critical-review-through-a-functional-view
#11
REVIEW
Maria Cristina Moran-Moguel, Stefania Petarra-Del Rio, Evangelina E Mayorquin-Galvan, Maria G Zavala-Cerna
Rheumatoid arthritis (RA) is a systemic autoimmune disease with severe joint inflammation and destruction associated with an inflammatory environment. The etiology behind RA remains to be elucidated; most updated concepts include the participation of environmental, proteomic, epigenetic, and genetic factors. Epigenetic is considered the missing link to explain genetic diversification among RA patients. Within epigenetic factors participating in RA, miRNAs are defined as small noncoding molecules with a length of approximately 22 nucleotides, capable of gene expression modulation, either negatively through inhibition of translation and degradation of the mRNA or positively through increasing the translation rate...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/29785143/pilot-study-of-the-antifibrotic-effects-of-the-multikinase-inhibitor-pacritinib-in-a-mouse-model-of-liver-fibrosis
#12
Suliman Al-Fayoumi, Taishi Hashiguchi, Yuka Shirakata, John Mascarenhas, Jack W Singer
Background: Fibrotic diseases result from an exuberant response to chronic inflammation. Myelofibrosis is the end result of inflammation in bone, caused by an inflammatory process triggered by production of abnormal myeloid cells driven by mutations affecting the JAK-STAT pathway. Inflammatory cytokine overproduction leads to increased mesenchymal cell proliferation, culminating in fibrosis. Although JAK2 inhibitors, such as the JAK1/2 inhibitor ruxolitinib and the JAK2/FLT3/CSF1R/IRAK1 inhibitor pacritinib suppress abnormal clone expansion in myelofibrosis, ruxolitinib does not appear to prevent or reverse bone-marrow fibrosis in most patients...
2018: Journal of Experimental Pharmacology
https://www.readbyqxmd.com/read/29783156/transient-impairment-of-olfactory-threshold-in-acute-multiple-sclerosis-relapse
#13
Gabriel Bsteh, Harald Hegen, Felix Ladstätter, Klaus Berek, Matthias Amprosi, Sebastian Wurth, Michael Auer, Franziska Di Pauli, Florian Deisenhammer, Andreas Lutterotti, Thomas Berger
BACKGROUND: Impairment of olfactory threshold is a feature of early and active relapsing remitting multiple sclerosis (RRMS). It predicts inflammatory disease activity and was reported to be transient. However, the timing of onset and resolve of olfactory threshold impairment remains unclear. OBJECTIVE: To prospectively assess the development of olfactory threshold in acute MS relapse over time in comparison to stable MS patients. METHODS: In a prospective observational design, we measured olfactory threshold by performing the Sniffin' Sticks test (minimum score 0, maximum score 16 reflecting optimal olfactory function) at baseline and after 4, 12 and 24 weeks...
May 18, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29783085/indoor-black-carbon-and-biomarkers-of-systemic-inflammation-and-endothelial-activation-in-copd-patients
#14
Eric Garshick, Stephanie T Grady, Jaime E Hart, Brent A Coull, Joel D Schwartz, Francine Laden, Marilyn L Moy, Petros Koutrakis
RATIONALE: Evidence linking traffic-related particle exposure to systemic effects in chronic obstructive lung disease (COPD) patients is limited. OBJECTIVES: Assess relationships between indoor black carbon (BC), a tracer of traffic-related particles, and plasma biomarkers of systemic inflammation and endothelial activation. METHODS: BC was measured by reflectance in fine particle samples over a mean of 7.6 days in homes of 85 COPD patients up to 4 times seasonally over a year...
May 18, 2018: Environmental Research
https://www.readbyqxmd.com/read/29781578/identification-of-an-anti-inflammation-protein-annexin-a1-in-tendon-derived-stem-cells-tdscs-of-cystic-fibrosis-mice-a-comparative-proteomic-analysis
#15
Yang Liu, Lu Feng, Hua Wang, Yu-Jia Wang, Hsiao-Chang Chan, Xiao-Hua Jiang, Wei-Ming Fu, Gang Li, Jin-Fang Zhang
PURPOSE: Our previous study reported an elevated inflammation during tendon injury in mice with cystic fibrosis (CF), indicating the inadequate management of inflammation due to dysfunction of the cystic fibrosis transmembrane conductance regulator (CFTR). The objective of this study is to identify the targets of CFTR that contribute to the abnormal inflammation during tendon injury. EXPERIMENTAL DESIGN: A two-dimensional gel electrophoresis and mass spectrometry-based comparative proteomics was performed to find the molecular targets of CFTR...
May 21, 2018: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/29781175/translational-safety-biomarkers-of-colonic-barrier-integrity-in-the-rat
#16
Tim Erkens, Ruud Bueters, Marjolein van Heerden, Filip Cuyckens, Rob Vreeken, Nick Goeminne, Lieve Lammens
The intestinal barrier controls intestinal permeability, and its disruption has been associated with multiple diseases. Therefore, preclinical safety biomarkers monitoring barrier integrity are essential during the development of drugs targeting the intestines, particularly if starting treatment early after onset of disease. Classical toxicology endpoints are not sensitive enough and therefore our objective was to identify non-invasive markers enabling early in vivo detection of colonic barrier perturbation...
May 20, 2018: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29780609/serum-heat-shock-protein-70-levels-as-a-biomarker-for-inflammatory-processes-in-multiple-sclerosis
#17
Patricia Lechner, Dorothea Buck, Lisa Sick, Bernhard Hemmer, Gabriele Multhoff
Background: Inflammatory and neurodegenerative processes are hallmarks of multiple sclerosis (MS). The synthesis of the major stress-inducible heat shock protein 70 (Hsp70) is induced by inflammation. Objective: The purpose of this study is to determine whether Hsp70 in serum can serve as a potential biomarker to distinguish inflammatory and neurodegenerative processes in MS. Methods: Serum was obtained from 94 patients: 26 clinically isolated syndrome (CIS), 40 relapsing-remitting MS (RRMS), 19 secondary progressive MS (SPMS), and nine primary progressive MS (PPMS)...
April 2018: Multiple Sclerosis Journal—Experimental, Translational and Clinical
https://www.readbyqxmd.com/read/29778854/proposed-stages-of-myocardial-phenotype-development-in-fabry-disease
#18
Sabrina Nordin, Rebecca Kozor, Katia Medina-Menacho, Amna Abdel-Gadir, Shanat Baig, Daniel M Sado, Ilaria Lobascio, Elaine Murphy, Robin H Lachmann, Atul Mehta, Nicola C Edwards, Uma Ramaswami, Richard P Steeds, Derralynn Hughes, James C Moon
OBJECTIVES: The authors sought to explore the Fabry myocardium in relation to storage, age, sex, structure, function, electrocardiogram changes, blood biomarkers, and inflammation/fibrosis. BACKGROUND: Fabry disease (FD) is a rare, x-linked lysosomal storage disorder. Mortality is mainly cardiovascular with men exhibiting cardiac symptoms earlier than women. By cardiovascular magnetic resonance, native T1 is low in FD because of sphingolipid accumulation. METHODS: A prospective, observational study of 182 FD (167 adults, 15 children; mean age 42 ± 17 years, 37% male) who underwent cardiovascular magnetic resonance including native T1, late gadolinium enhancement (LGE), and extracellular volume fraction, 12-lead electrocardiogram, and blood biomarkers (troponin and N-terminal pro-brain natriuretic peptide)...
May 11, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29777921/comparison-of-heavy-metals-parasites-and-histopathology-in-sculpins-myoxocephalus-spp-from-two-sites-at-a-lead-zinc-mine-in-north-east-greenland
#19
Rasmus Dyrmose Nørregaard, Mai Dang, Lis Bach, Ole Geertz-Hansen, Kim Gustavson, Peter Aastrup, Pall S Leifsson, Jens Søndergaard, Barbara Nowak, Christian Sonne
The former lead-zinc mine at Mestersvig, Greenland, continues to contaminate the surrounding environment despite its operations ceasing over 50 years ago. Elevated concentrations of heavy metals are found in water, sediment and biota in the terrestrial, freshwater and marine environments. To shed light on the present contamination and its potential effects on local fish we investigated gill and liver histology of sculpins (Myoxocephalus spp.) around the former mining area. Two species of sculpins were caught; shorthorn sculpins (M...
May 16, 2018: Environmental Research
https://www.readbyqxmd.com/read/29777877/multi-walled-carbon-nanotubeinduced-inhalation-toxicity-recognizing-nano-bis-demethoxy-curcumin-analog-as-an-ameliorating-candidate
#20
Arul Prakash Francis, Thiyagarajan Devasena, Selvam Ganapathy, Venkata Rajsekhar Palla, Prakhya Balakrishna Murthy, Sundara Ramaprabhu
Human beings and ecosystems are being possibly exposed to CNTs, as there is a rise in global production rate of carbon nanotubes (CNTs). This may affect the health of humans and increases the environmental risk. We have already reported the pulmonary toxicity due to the inhalation of MWCNTs. We claim that a compound with anti-inflammatory and antioxidant activity may ameliorate the CNT-induced toxic effect. With this view, we have investigated the ameliorative effect of intravenously-administered nano bis-demethoxy curcumin analog (NBDMCA) against MWCNTs-induced inhalation toxicity by examining the lung histopathology for inflammatory cell dynamics, pulmonary remodeling and estimating the inflammatory biomarkers in the broncho-alveolar lavage fluid...
May 16, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
keyword
keyword
104089
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"