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steroid use assessment in closed traumatic brain injury

Dhananjay R Namjoshi, Wai Hang Cheng, Michael Carr, Kris M Martens, Shahab Zareyan, Anna Wilkinson, Kurt A McInnes, Peter A Cripton, Cheryl L Wellington
Concussion is a serious health concern. Concussion in athletes is of particular interest with respect to the relationship of concussion exposure to risk of chronic traumatic encephalopathy (CTE), a neurodegenerative condition associated with altered cognitive and psychiatric functions and profound tauopathy. However, much remains to be learned about factors other than cumulative exposure that could influence concussion pathogenesis. Approximately 20% of CTE cases report a history of substance use including androgenic-anabolic steroids (AAS)...
2016: PloS One
Karim Asehnoune, Philippe Seguin, Jeremy Allary, Fanny Feuillet, Sigismond Lasocki, Fabrice Cook, Hervé Floch, Russell Chabanne, Thomas Geeraerts, Claire Roger, Pierre F Perrigault, Jean L Hanouz, Anne C Lukaszewicz, Matthieu Biais, Perrine Boucheix, Claire Dahyot-Fizelier, Xavier Capdevila, Pierre J Mahe, Pascale Le Maguet, Catherine Paugam-Burtz, Soizic Gergaud, Benoit Plaud, Jean M Constantin, Yannick Malledant, Laurent Flet, Véronique Sebille, Antoine Roquilly
BACKGROUND: Hospital-acquired pneumonia is common after traumatic brain injury, and might be partly a result of traumatic brain injury-induced adrenal insufficiency. We tested the efficacy of low-dose hydrocortisone with fludrocortisone for the prevention of hospital-acquired pneumonia. METHODS: We did this double-blind, phase 3, placebo-controlled trial in 19 intensive care units in France. We enrolled patients aged 15-65 years in the first 24 h after severe traumatic brain injury (Glasgow coma scale score ≤8 and trauma-associated lesion on brain CT scan)...
September 2014: Lancet Respiratory Medicine
Si Yun Ng, Bridgette D Semple, M Cristina Morganti-Kossmann, Nicole Bye
Neurogenesis is stimulated following injury to the adult brain and could potentially contribute to tissue repair. However, evidence suggests that microglia activated in response to injury are detrimental to the survival of new neurons, thus limiting the neurogenic response. The aim of this study was to determine the effect of the anti-inflammatory drug minocycline on neurogenesis and functional recovery after a closed head injury model of focal traumatic brain injury (TBI). Beginning 30 min after trauma, minocycline was administered for up to 2 weeks and bromodeoxyuridine was given on days 1-4 to label proliferating cells...
May 1, 2012: Journal of Neurotrauma
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