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anti-edema treatment in traumatic brain injury

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https://www.readbyqxmd.com/read/27924525/a-three-day-consecutive-fingolimod-administration-improves-neurological-functions-and-modulates-multiple-immune-responses-of-cci-mice
#1
Chuang Gao, Yu Qian, Jinhao Huang, Dong Wang, Wanqiang Su, Peng Wang, Linyue Guo, Wei Quan, Shuo An, Jianning Zhang, Rongcai Jiang
Excessive inflammation after traumatic brain injury (TBI) is a major cause of secondary TBI. Though several inflammatory biomarkers have been postulated as the risk factors of TBI, there has not been any comprehensive description of them. Fingolimod, a new kind of immunomodulatory agent which can diminish various kinds of inflammatory responses, has shown additional therapeutic effects in the treatment of intracranial cerebral hematoma (ICH), ischemia, spinal cord injury (SCI), and many other CNS disorders...
December 6, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27734181/ursolic-acid-ameliorates-early-brain-injury-after-experimental-traumatic-brain-injury-in-mice-by-activating-the-nrf2-pathway
#2
Hui Ding, Handong Wang, Lin Zhu, Wuting Wei
Previous studies have indicated oxidative stress and inflammatory injury as significant contributors to the secondary damage associated with traumatic brain injury (TBI). Ursolic acid (UA) has been demonstrated to exert anti-oxidative and anti-inflammatory effects on cerebral ischemia by activating the nuclear factor-erythroid 2-related factor 2 (Nrf2) pathway. However, the effects of UA on TBI remain unclear. The aim of this study is to evaluate the potential roles of UA in the activation of the Nrf2 pathway using an experimental TBI model and the underlying mechanism...
October 12, 2016: Neurochemical Research
https://www.readbyqxmd.com/read/27581370/astaxanthin-alleviates-cerebral-edema-by-modulating-nkcc1-and-aqp4-expression-after-traumatic-brain-injury-in-mice
#3
Mingkun Zhang, Zhenwen Cui, Hua Cui, Yang Cao, Chunlong Zhong, Yong Wang
BACKGROUND: Astaxanthin is a carotenoid pigment that possesses potent antioxidative, anti-inflammatory, antitumor, and immunomodulatory activities. Previous studies have demonstrated that astaxanthin displays potential neuroprotective properties for the treatment of central nervous system diseases, such as ischemic brain injury and subarachnoid hemorrhage. This study explored whether astaxanthin is neuroprotective and ameliorates neurological deficits following traumatic brain injury (TBI)...
2016: BMC Neuroscience
https://www.readbyqxmd.com/read/27565146/etifoxine-improves-sensorimotor-deficits-and-reduces-glial-activation-neuronal-degeneration-and-neuroinflammation-in-a-rat-model-of-traumatic-brain-injury
#4
Emmanuelle Simon-O'Brien, Delphine Gauthier, Véronique Riban, Marc Verleye
BACKGROUND: Traumatic brain injury (TBI) results in important neurological impairments which occur through a cascade of deleterious physiological events over time. There are currently no effective treatments to prevent these consequences. TBI is followed not only by an inflammatory response but also by a profound reorganization of the GABAergic system and a dysregulation of translocator protein 18 kDa (TSPO). Etifoxine is an anxiolytic compound that belongs to the benzoxazine family...
2016: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/27465336/telmisartan-reduced-cerebral-edema-by-inhibiting-nlrp3-inflammasome-in-mice-with-cold-brain-injury
#5
Xin Wei, Chen-Chen Hu, Ya-Li Zhang, Shang-Long Yao, Wei-Ke Mao
The aim of this study was to investigate the possible beneficial role of telmisartan in cerebral edema after traumatic brain injury (TBI) and the potential mechanisms related to the nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) pyrin domain-containing 3 (NLRP3) inflammasome activation. TBI model was established by cold-induced brain injury. Male C57BL/6 mice were randomly assigned into 3, 6, 12, 24, 48 and 72 h survival groups to investigate cerebral edema development with time and received 0, 5, 10, 20 and 40 mg/kg telmisartan by oral gavage, 1 h prior to TBI to determine the efficient anti-edemic dose...
August 2016: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/27389389/evaluation-of-laser-bacterial-anti-fouling-of-transparent-nanocrystalline-yttria-stabilized-zirconia-cranial-implant
#6
Yasaman Damestani, Natalie De Howitt, David L Halaney, Javier E Garay, Guillermo Aguilar
BACKGROUND AND OBJECTIVE: The development and feasibility of a novel nanocrystalline yttria-stabilized-zirconia (nc-YSZ) cranial implant has been recently established. The purpose of what we now call "window to the brain (WttB)" implant (or platform), is to improve patient care by providing a technique for delivery and/or collection of light into/from the brain, on demand, over large areas, and on a chronically recurring basis without the need for repeated craniotomies. WttB holds the transformative potential for enhancing light-based diagnosis and treatment of a wide variety of brain pathologies including cerebral edema, traumatic brain injury, stroke, glioma, and neurodegenerative diseases...
July 8, 2016: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/26883519/the-ampar-antagonist-perampanel-attenuates-traumatic-brain-injury-through-anti-oxidative-and-anti-inflammatory-activity
#7
Tao Chen, Shu-Hui Dai, Zhi-Quan Jiang, Peng Luo, Xiao-Fan Jiang, Zhou Fei, Song-Bai Gui, Yi-Long Qi
Perampanel is a novel α-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor (AMPAR) antagonist, approved in over 35 countries as an adjunctive therapy for the treatment of seizures. Recently, it was found to exert protective effects against ischemic neuronal injury in vitro. In the present study, we investigated the potential protective effects of perampanel in a traumatic brain injury (TBI) model in rats. Oral administration with perampanel at a dose of 5 mg/kg exerted no major organ-related toxicities...
February 16, 2016: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/26826009/hydrogen-rich-water-attenuates-brain-damage-and-inflammation-after-traumatic-brain-injury-in-rats
#8
Runfa Tian, Zonggang Hou, Shuyu Hao, Weichuan Wu, Xiang Mao, Xiaogang Tao, Te Lu, Baiyun Liu
Inflammation and oxidative stress are the two major causes of apoptosis after traumatic brain injury (TBI). Most previous studies of the neuroprotective effects of hydrogen-rich water on TBI primarily focused on antioxidant effects. The present study investigated whether hydrogen-rich water (HRW) could attenuate brain damage and inflammation after traumatic brain injury in rats. A TBI model was induced using a controlled cortical impact injury. HRW or distilled water was injected intraperitoneally daily following surgery...
April 15, 2016: Brain Research
https://www.readbyqxmd.com/read/26546505/sirt2-inhibition-exacerbates-neuroinflammation-and-blood-brain-barrier-disruption-in-experimental-traumatic-brain-injury-by-enhancing-nf-%C3%AE%C2%BAb-p65-acetylation-and-activation
#9
Fang Yuan, Zhi-Ming Xu, Li-Yan Lu, Hui Nie, Jun Ding, Wei-Hai Ying, Heng-Li Tian
Sirtuin 2 (SIRT2) is a member of the sirtuin family of NAD(+) -dependent protein deacetylases. In recent years, SIRT2 inhibition has emerged as a promising treatment for neurodegenerative diseases. However, to date, there is no evidence of a specific role for SIRT2 in traumatic brain injury (TBI). We investigated the effects of SIRT2 inhibition on experimental TBI using the controlled cortical impact (CCI) injury model. Adult male mice underwent CCI or sham surgery. A selective brain-permeable SIRT2 inhibitor, AK-7, was administrated 30 min before injury...
February 2016: Journal of Neurochemistry
https://www.readbyqxmd.com/read/26484701/anti-edema-effects-of-rhepo-in-experimental-traumatic-brain-injury
#10
Rodolfo Gatto, Mihir Chauhan, Neelima Chauhan
PURPOSE: Traumatic brain injury (TBI) is one of the leading causes of disability and death which begins with the formation of edema as the persistent primary causative factor in TBI. Although medical management of cerebral edema by hypothermia, ventriculostomy, mannitol or hypertonic saline have been effective in treating edema, many of these therapies end up with some neurologic deficits, necessitating novel treatment options for treating post-TBI edema. This study investigated edema reducing effects of recombinant human Erythropoietin (rhEPO) in reducing acute brain edema in the CCI mouse model of TBI...
2015: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/26399249/vagus-nerve-stimulation-and-other-neuromodulation-methods-for-treatment-of-traumatic-brain-injury
#11
Daniel Neren, Matthew D Johnson, Wynn Legon, Salam P Bachour, Geoffrey Ling, Afshin A Divani
The objective of this paper is to review the current literature regarding the use of vagus nerve stimulation (VNS) in preclinical models of traumatic brain injury (TBI) as well as discuss the potential role of VNS along with alternative neuromodulation approaches in the treatment of human TBI. Data from previous studies have demonstrated VNS-mediated improvement following TBI in animal models. In these cases, VNS was observed to enhance motor and cognitive recovery, attenuate cerebral edema and inflammation, reduce blood brain barrier breakdown, and confer neuroprotective effects...
April 2016: Neurocritical Care
https://www.readbyqxmd.com/read/26004757/dextromethorphan-provides-neuroprotection-via-anti-inflammatory-and-anti-excitotoxicity-effects-in-the-cortex-following-traumatic-brain-injury
#12
Benfang Pu, Yonghua Xue, Qingming Wang, Chunhui Hua, Xinyuan Li
Traumatic brain injury (TBI) is caused by primary and secondary injury mechanisms. TBI induces a certain amount of inflammatory responses and glutamate excitotoxicity that are believed to participate in the pathogenesis of secondary injury. The non‑narcotic anti‑tussive drug dextromethorphan (DM) has been reported to have a high safety profile in humans and its neuroprotective against a variety of disorders, including cerebral ischemia, epilepsy and acute brain injury. However, few studies have explored the underlying mechanisms of the neuroprotective effects of DM in animals in the setting of TBI...
September 2015: Molecular Medicine Reports
https://www.readbyqxmd.com/read/25822252/preservation-of-the-blood-brain-barrier-and-cortical-neuronal-tissue-by-liraglutide-a-long-acting-glucagon-like-1-analogue-after-experimental-traumatic-brain-injury
#13
Jakob Hakon, Karsten Ruscher, Bertil Romner, Gregor Tomasevic
Cerebral edema is a common complication following moderate and severe traumatic brain injury (TBI), and a significant risk factor for development of neuronal death and deterioration of neurological outcome. To this date, medical approaches that effectively alleviate cerebral edema and neuronal death after TBI are not available. Glucagon-like peptide-1 (GLP-1) has anti-inflammatory properties on cerebral endothelium and exerts neuroprotective effects. Here, we investigated the effects of GLP-1 on secondary injury after moderate and severe TBI...
2015: PloS One
https://www.readbyqxmd.com/read/25721934/palmitoyl-serine-an-endogenous-neuroprotective-endocannabinoid-like-entity-after-traumatic-brain-injury
#14
Aniv Mann, Reem Smoum, Victoria Trembovler, Alexander Alexandrovich, Aviva Breuer, Raphael Mechoulam, Esther Shohami
The endocannabinoid (eCB) system helps recovery following traumatic brain injury (TBI). Treatment with 2-arachidonoylglycerol (2-AG), a cerebral eCB ligand, was found to ameliorate the secondary damage. Interestingly, the fatty acid amino acid amide (FAAA) N-arachidonoyl-L-serine (AraS) exerts similar eCB dependent neuroprotective. The present study aimed to investigate the effects of the FAAA palmitoyl-serine (PalmS) following TBI. We utilized the TBI model in mice to examine the therapeutic potential of PalmS, injected 1 h following closed head injury (CHI)...
June 2015: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/25620952/efficacy-and-safety-of-panax-notoginseng-saponin-therapy-for-acute-intracerebral-hemorrhage-meta-analysis-and-mini-review-of-potential-mechanisms-of-action
#15
Dongying Xu, Ping Huang, Zhaosheng Yu, Daniel H Xing, Shuai Ouyang, Guoqiang Xing
UNLABELLED: Intracranial/intracerebral hemorrhage (ICH) is a leading cause of death and disability in people with traumatic brain injury (TBI) and stroke. No proven drug is available for ICH. Panax notoginseng (total saponin extraction, PNS) is one of the most valuable herb medicines for stroke and cerebralvascular disorders in China. We searched for randomized controlled clinical trials (RCTs) involving PNS injection to treat cerebral hemorrhage for meta-analysis from various databases including the Chinese Stroke Trials Register, the trials register of the Cochrane Complementary Medicine Field, the Cochrane Central Register of Controlled Trials, MEDLINE, Chinese BioMedical disk, and China Doctorate/Master Dissertations Databases...
2014: Frontiers in Neurology
https://www.readbyqxmd.com/read/25587567/role-of-melatonin-in-traumatic-brain-injury-and-spinal-cord-injury
#16
REVIEW
Mehar Naseem, Suhel Parvez
Brain and spinal cord are implicated in incidences of two of the most severe injuries of central nervous system (CNS). Traumatic brain injury (TBI) is a devastating neurological deficit involving primary and secondary injury cascades. The primary and secondary mechanisms include complex consequences of activation of proinflammatory cytokines, cerebral edema, upregulation of NF-κ β, disruption of blood-brain barrier (BBB), and oxidative stress. Spinal cord injury (SCI) includes primary and secondary injury cascades...
2014: TheScientificWorldJournal
https://www.readbyqxmd.com/read/25579788/a-single-dose-of-ppar%C3%AE-agonist-pioglitazone-reduces-cortical-oxidative-damage-and-microglial-reaction-following-lateral-fluid-percussion-brain-injury-in-rats
#17
Kristina Pilipović, Željko Župan, Petra Dolenec, Jasenka Mršić-Pelčić, Gordana Župan
Neuroprotective actions of the peroxisome proliferator-activated receptor-γ (PPARγ) agonists have been observed in various animal models of the brain injuries. In this study we examined the effects of a single dose of pioglitazone on oxidative and inflammatory parameters as well as on neurodegeneration and the edema formation in the rat parietal cortex following traumatic brain injury (TBI) induced by the lateral fluid percussion injury (LFPI) method. Pioglitazone was administered in a dose of 1mg/kg at 10min after the brain trauma...
June 3, 2015: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/25249935/c1-inhibitor-protects-from-focal-brain-trauma-in-a-cortical-cryolesion-mice-model-by-reducing-thrombo-inflammation
#18
Christiane Albert-Weissenberger, Stine Mencl, Michael K Schuhmann, Irmak Salur, Eva Göb, Friederike Langhauser, Sarah Hopp, Nelli Hennig, Sven G Meuth, Marc W Nolte, Anna-Leena Sirén, Christoph Kleinschnitz
Traumatic brain injury (TBI) induces a strong inflammatory response which includes blood-brain barrier damage, edema formation and infiltration of different immune cell subsets. More recently, microvascular thrombosis has been identified as another pathophysiological feature of TBI. The contact-kinin system represents an interface between inflammatory and thrombotic circuits and is activated in different neurological diseases. C1-Inhibitor counteracts activation of the contact-kinin system at multiple levels...
2014: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/24669820/curcumin-attenuates-acute-inflammatory-injury-by-inhibiting-the-tlr4-myd88-nf-%C3%AE%C2%BAb-signaling-pathway-in-experimental-traumatic-brain-injury
#19
Hai-tao Zhu, Chen Bian, Ji-chao Yuan, Wei-hua Chu, Xin Xiang, Fei Chen, Cheng-shi Wang, Hua Feng, Jiang-Kai Lin
BACKGROUND: Traumatic brain injury (TBI) initiates a neuroinflammatory cascade that contributes to substantial neuronal damage and behavioral impairment, and Toll-like receptor 4 (TLR4) is an important mediator of thiscascade. In the current study, we tested the hypothesis that curcumin, a phytochemical compound with potent anti-inflammatory properties that is extracted from the rhizome Curcuma longa, alleviates acute inflammatory injury mediated by TLR4 following TBI. METHODS: Neurological function, brain water content and cytokine levels were tested in TLR4⁻/⁻ mice subjected to weight-drop contusion injury...
2014: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/24583571/hypertonic-saline-as-a-therapy-for-pediatric-concussive-pain-a-randomized-controlled-trial-of-symptom-treatment-in-the-emergency-department
#20
RANDOMIZED CONTROLLED TRIAL
Angela Lumba-Brown, Jim Harley, Simon Lucio, Florin Vaida, Mary Hilfiker
OBJECTIVE: Three-percent hypertonic saline (HTS) is a hyperosmotic therapy used in pediatric traumatic brain injury to treat increased intracranial pressure and cerebral edema. It also promotes plasma volume expansion and cerebral perfusion pressure, immunomodulation, and anti-inflammatory response. We hypothesized that HTS will improve concussive symptoms of mild traumatic brain injury. METHODS: The study was a prospective, double-blind, randomized controlled trial...
March 2014: Pediatric Emergency Care
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