Brian E Mace, Eric Lassiter, Evangeline Kamalini Arulraja, Eduardo Chaparro, Viviana Cantillana, Rupali Gupta, Timothy D Faw, Daniel T Laskowitz, Brad J Kolls
Traumatic brain injury (TBI) from closed-head trauma is a leading cause of disability, with limited effective interventions. Many TBI models impact brain parenchyma directly, and are limited by the fact that these forces do not recapitulate clinically relevant closed head injury. However, applying clinically relevant injury mechanics to the intact skull may lead to variability and as a result, preclinical modeling TBI remains a challenge. Current models often do not explore sex differences in TBI, which is critically important for translation to clinical practice...
January 10, 2024: Neurological Research