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https://www.readbyqxmd.com/read/28546529/the-safety-of-electrical-cardioversion-under-the-control-of-transesophageal-echocardiography-in-patients-with-atrial-fibrillation-and-inadequate-anticoagulation
#1
Joanna Zaprutko, Artur Baszko, Michał Michalak, Karol Kochman, Radosław Szymański, Jan Kłopocki, Anna Nowicka, Rafał Dankowski, Marek Michalski, Piotr Kałmucki, Andrzej Szyszka
INTRODUCTION    Restoring sinus rhythm in patients with atrial fibrillation (AF)/atrial flutter (AF) requires adequate oral anticoagulation (OAC) prior to direct current cardioversion (DCC). Some patients eligible for DCC are not properly anticoagulated. OBJECTIVES    Assessment of risk factors for thrombus and spontaneous echo contrast (SEC) in the left atrium (LA) as well as the safety profile of DCC under transesophageal echocardiography control (TEE) in patients with inadequate anticoagulation. PATIENTS AND METHODS    From the cohort of 316 patients admitted for DCC, 139 (age 63...
May 25, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/28546017/delayed-left-atrial-appendage-contrast-filling-in-computed-tomograms-after-percutaneous-left-atrial-appendage-occlusion
#2
Yeong-Min Lim, Jung-Sun Kim, Tae-Hoon Kim, Jae-Sun Uhm, Chi Young Shim, Boyoung Joung, Geu-Ru Hong, Moon-Hyoung Lee, Yang-Soo Jang, Hui-Nam Pak
BACKGROUND: The gold standard for the follow-up of left atrial appendage occlusion (LAAO) is performing transesophageal echocardiogram (TEE) at 45 days after LAAO; however, the duration for complete LAA seal-off after percutaneous LAAO is unknown in humans. We retrospectively evaluated the LAA contrast-filling (CF) rate in follow-up cardiac computed tomography (CT) scans after LAAO. METHODS: We included 35 patients (age 67.5±10.9 years, CHA2DS2VASc 4.2±1.6, HAS-BLED 3...
May 22, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/28544366/enumeration-of-wt1-specific-cd8-t-cells-for-clinical-application-using-an-mhc-streptamer-based-no-wash-single-platform-flow-cytometric-assay
#3
Sarah Matko, Madeleine Teichert, Antje Tunger, Marc Schmitz, Martin Bornhauser, Torsten Tonn, Marcus Odendahl
The advent of novel strategies to generate leukemia-associated-antigen (LAA)-specific T cells for adoptive immunotherapies creates a demand for standardized good laboratory practice (GLP)-compliant enumeration assays to provide a secure clinical environment-whether it is to identify potential donors, define therapeutic doses for transplantation, or monitor clinical success. Here, we introduce a no-wash assay based on single-platform cell enumeration and Streptamer staining to determine the Wilms' tumor antigen 1 (WT1)-specific T cell immunity in clinical samples...
May 25, 2017: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
https://www.readbyqxmd.com/read/28536425/intravenous-thrombolysis-in-chinese-patients-with-different-subtype-of-mild-stroke-thrombolysis-in-patients-with-mild-stroke
#4
Weiqi Chen, Yuesong Pan, Xingquan Zhao, Liping Liu, Hao Li, Xiaoling Liao, Chunjuan Wang, Yilong Wang, Yongjun Wang
Thrombolysis treatment for patients with mild stroke is controversial. The aim of our study was to investigate whether patients with mild stroke or its specific etiologic subtype might benefit from rt-PA therapy. Data were derived from two cohorts of patients with and without rt-PA treatment: (1) the Thrombolysis Implementation and Monitor of Acute Ischemic Stroke in China (TIMS-China) and (2) the China National Stroke Registry (CNSR) database. Patients with mild stroke (defined as National Institutes of Health Stroke Scale ≤5) receiving the rt-PA therapy and without rt-PA therapy were matched in 1:2 for age, sex, stroke severity and etiologic subtype...
May 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28527539/editorial-commentary-here-today-gone-tomorrow-the-laa-and-stroke
#5
EDITORIAL
Paul A Friedman, David R Holmes
No abstract text is available yet for this article.
April 11, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28525549/the-change-in-circulating-galectin-3-predicts-absence-of-atrial-fibrillation-after-thoracoscopic-surgical-ablation
#6
Wouter R Berger, Benoît Jagu, Nicoline W E van den Berg, Dean R P P Chan Pin Yin, Jan P van Straalen, Onno J de Boer, Antoine H G Driessen, Jolien Neefs, Sébastien P J Krul, WimJan P van Boven, Allard C van der Wal, Joris R de Groot
Aims: Galectin-3 (Gal-3) is an important mediator of cardiac fibrosis, particularly in heart failure. Increased Gal-3 concentration (Gal-3), associated with increased risk of developing atrial fibrillation (AF), may reflect atrial fibrotic remodelling underlying AF progression. We aimed to investigate whether the change in serum Gal-3 reflects alterations of the arrhythmogenic atrial substrate following thoracoscopic AF surgery, and predicts absence of AF. Methods and results: Consecutive patients undergoing thoracoscopic AF surgery were included...
May 19, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28506939/printed-mdct-3d-models-for-prediction-of-left-atrial-appendage-laa-occluder-device-size-a-feasibility-study
#7
Orly Goitein, Noam Fink, Victor Guetta, Roy Beinart, Yafim Brodov, Eli Konen, David Goitein, Elio Di Segni, Avishay Grupper, Michael Glikson
AIMS: Trans-esophageal echocardiography (TEE) and MDCT currently serve as imaging modalities for left atrial appendage (LAA) occlusion pre-procedural planning. We assessed the feasibility of multi-detector CT (MDCT) based models to predict the correct size of device for LAA occlusion procedures. METHODS AND RESULTS: Patients planned for LAA occlusion underwent MDCT before implantation, which was used for creating and printing 3D LAA models. Three cardiologists evaluated the 3D models and predicted the correct size of the device by manual manipulation, these predictions were compared with the actual device implanted during the procedure...
May 16, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28506266/impact-of-preterm-birth-on-infant-mortality-for-newborns-with-congenital-heart-defects-the-epicard-population-based-cohort-study
#8
Enora Laas, Nathalie Lelong, Pierre-Yves Ancel, Damien Bonnet, Lucile Houyel, Jean-François Magny, Thibaut Andrieu, François Goffinet, Babak Khoshnood
BACKGROUND: Congenital heart defects (CHD) and preterm birth (PTB) are major causes of infant mortality. However, limited data exist on risk of mortality associated with PTB for newborns with CHD. Our objective was to assess impact of PTB on risk of infant mortality for newborns with CHD, while taking into account the role of associated anomalies and other potentially confounding factors. METHODS: We used data on 2172 live births from a prospective population-based cohort study of CHD (the EPICARD Study) and compared neonatal, post-neonatal and overall infant mortality for infants born at <32, 32-34 and 35-36 weeks vs...
May 15, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28505082/supervised-clustering-of-adipokines-and-hormonal-receptors-predict-prognosis-in-a-population-of-obese-women-with-type-1-endometrial-cancer
#9
Jennifer Uzan, Enora Laas, Issam Abd Alsamad, Dounia Skalli, Dhouha Mansouri, Bassam Haddad, Cyril Touboul
Obesity is a major risk factor for endometrial cancer (EC). Yet, its impact on prognosis is controversial. Obesity is associated with metabolic and hormonal dysregulation as well as adipokines increase. The aim of this study was to characterize the expression of biological factors related to obesity within the tumor and evaluate their impact on prognosis. One hundred and thirty-six patients, including 55 obese patients, with endometrioid type I EC operated by total hysterectomy were included in this retrospective study conducted in a Tertiary teaching hospital between 2000 and 2013...
May 13, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28504234/spain-coronary-and-structural-heart-interventions-from-2010-to-2015
#10
Bruno García Del Blanco, Pilar Jiménez Quevedo, José D Diaz, Felipe Hernández, José Ramón Rumoroso, Manel Sabaté, José Maria de la Torre Hernandez, Ana Serrador, Armando Pérez de Prado, Javier Goicolea, Ramiro Trillo, Manolo Pan
Since 1990 The Spanish Society of Cardiology Working Group on Cardiac Catheterization and Interventional Cardiology has presented a yearly report on the data collected in the National Registry, with online support since 2010. The Steering Committee has analysed all data provided voluntarily by institutions, which consisted of a total of anywhere between 105 and 113 hospitals. Medical care was provided to a population of 46.8 million inhabitants in 2015. During this period, diagnostic procedures increased progressively from 2010, reaching a maximum of 145,836 in 2015, 86% (125,484) corresponding to coronary angiograms...
May 15, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28504228/italy-coronary-and-structural-heart-interventions-from-2010-to-2015
#11
Sergio Berti, Ferdinando Varbella, Alfredo Marchese, Luigi Emilio Pastormerlo, Giuseppe Musumeci
The aim of this report is to analyse trends in Italian cathlab activity between 2010 and 2015. Data were obtained from the national database of the Italian Society of Interventional Cardiology (GISE), which includes 97% of Italian cardiac catheterisation laboratories. The number of percutaneous coronary interventions (PCI) has remained relatively stable in the past five years. We have observed a significant increase in the number of primary PCI (pPCI) from 471.5 to 557.5 per million inhabitants with a consequent reduction of rescue primary PCI/fibrinolysis...
May 15, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28501930/association-of-gwas-reported-variant-rs11196288-near-habp2-with-ischemic-stroke-in-chinese-han-population
#12
Shao-Hua Li, Chang-He Shi, Yu-Sheng Li, Fang Li, Mi-Bo Tang, Xin-Jing Liu, Shuo Zhang, Zhi-Lei Wang, Bo Song, Yu-Ming Xu
A recent genome-wide association analysis identified a novel single nucleotide polymorphism locus on chromosome 10q25.3 (rs11196288, near HABP2) associated with the risk of early-onset ischemic stroke (IS) in European population, but not with late-onset IS. However, the role of this genome-wide association study (GWAS)-reported variant in ischemic stroke in Chinese Han population remained unknown. In our study, 389 adult ischemic stroke patients with an age of onset <60 years and 389 matched healthy controls were enrolled to investigate association of rs11196288 genotypes with early-onset ischemic stroke and its subtypes; the association was further examined in another independent population consisting of 349 ischemic stroke patients with an age of onset ≧60 years and 349 matched healthy individuals...
May 13, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/28500479/-catheter-ablation-of-persistent-atrial-fibrillation-where-do-we-go
#13
C Lemeš, K-H Kuck, S Mathew
Despite the very promising initial results of clinical studies, catheter ablation of persistent atrial fibrillation (AF) remains a challenge in modern electrophysiology. On the basis of the hypothesized pathophysiological mechanisms, a variety of ablation strategies have been developed over the course of time. The current ablation strategies range from pulmonary vein isolation (PVI) alone as first-line therapy, through ablation of multiple linear lesions, ablation of complex fractionated atrial electrograms (CFAE), rotor ablation, isolation of fibrotic and scar tissue up to isolation of the left atrial appendage (LAA); however, it is unclear even to the present day whether these complex and time-consuming strategies actually improve the success rate of ablation therapy...
May 12, 2017: Herz
https://www.readbyqxmd.com/read/28495686/incidence-of-non-pulmonary-cancer-and-lung-cancer-by-amount-of-emphysema-and-airway-wall-thickness-a-community-based-cohort
#14
Ane Aamli Gagnat, Miriam Gjerdevik, Frode Gallefoss, Harvey O Coxson, Amund Gulsvik, Per Bakke
There is limited knowledge about the prognostic value of quantitative computed tomography (CT) measures of emphysema and airway wall thickness in cancer.The aim of this study was to investigate if using CT to quantitatively assess the amount of emphysema and airway wall thickness independently predicts the subsequent incidence of non-pulmonary cancer and lung cancer.In the GenKOLS study of 2003-2005, 947 ever-smokers performed spirometry and underwent CT examination. The main predictors were the amount of emphysema measured by the percentage of low attenuation areas (%LAA) on CT and standardised measures of airway wall thickness (AWT-PI10)...
May 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28495117/first-experience-with-the-watchman-flx-occluder-for-percutaneous-left-atrial-appendage-closure
#15
Julia Seeger, Ralf Birkemeyer, Wolfgang Rottbauer, Jochen Wöhrle
BACKGROUND: We aimed to evaluate efficacy and safety of left atrial appendage (LAA) closure with the new Watchman FLX and analyze procedural features in a consecutive series of high risk non-valvular atrial fibrillation patients. METHODS AND RESULTS: Twelve consecutive non-valvular atrial fibrillation patients (age 76.6±7.8years) at high risk for stroke (CHA2DS2-VASc-Score 5.5±0.9) and bleeding (HAS-BLED-Score 3.8±0.9), received LAA closure with the Watchman FLX...
April 29, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/28477098/predictors-of-thrombus-formation-after-percutaneous-left-atrial-appendage-closure-using-the-watchman-device
#16
Hidehiro Kaneko, Michael Neuss, Jens Weissenborn, Christian Butter
Percutaneous left atrial appendage (LAA) closure using the WATCHMAN device is a novel option for prevention of stroke associated with atrial fibrillation. However, device-related thrombus (DRT) formation is a concern after WATCHMAN implantation and the predictors of DRT still remain unclear. We aimed to clarify the predictors of DRT after WATCHMAN implantation by analyzing 78 patients (50 males, 72 ± 8 years, average CHA2DS2-VASc score of 4.3 + 1.8) who had undergone WATCHMAN implantation. WATCHMAN was successfully implanted in all patients and four (5%) developed DRT...
May 5, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28477011/simultaneous-in-vitro-generation-of-cd8-and-cd4-t-cells-specific-to-three-universal-tumor-associated-antigens-of-wt1-survivin-and-tert-and-adoptive-t-cell-transfer-for-the-treatment-of-acute-myeloid-leukemia
#17
Hyun-Jung Sohn, Ji Yoon Lee, Hyun-Joo Lee, Dae-Hee Sohn, Hyun-Il Cho, Hee-Je Kim, Tai-Gyu Kim
Previously, we found that most patients with acute myeloid leukemia (AML) expressed at least one of the leukemic associated antigens (LAAs) WT1, survivin and TERT, and different combinations of the three LAAs predicted negative clinical outcomes. Multi-tumor antigen-specific T cells were generated to overcome antigenic variation and may be sufficient to maximize antitumoral effects. To generate triple antigen-specific (Tri)-T cells that recognize three LAAs, dendritic cells (DCs) were transfected with three tumor antigen-encoding RNAs...
April 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/28476508/risk-factors-of-neurological-deterioration-in-patients-with-cerebral-infarction-due-to-large-artery-atherosclerosis
#18
Nobuaki Yamamoto, Junichiro Satomi, Yuki Yamamoto, Kenji Shono, Yasuhisa Kanematsu, Yuishin Izumi, Shinji Nagahiro, Ryuji Kaji
BACKGROUND: In some patients with acute ischemic stroke, neurological deterioration (ND) is observed, and it is difficult to predict at the time of admission. Especially in some patients with large-artery atherosclerosis (LAA), aggressive medical treatments and surgical interventions might be helpful to prevent ND. Therefore, we investigated factors associated with ND in patients with LAA. METHODS: We studied patients with LAA who were admitted to our hospital. We divided them into 2 groups with (group 1) and without deterioration (group 2), and evaluated their medical records, risk factors, and radiological findings, such as number of diffusion-positive lesion and degree of stenosis...
May 2, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28475380/thromboembolic-and-bleeding-risks-of-oral-anticoagulation-therapy-in-patients-undergoing-atrial-fibrillation-ablation
#19
David F Briceño, Nidhi Madan, Jorge Romero, Alejandra Londoño, Pedro A Villablanca, Andrea Natale, Luigi Di Biase
Atrial fibrillation (AF) is a cause of significant morbidity and mortality. Catheter ablation for AF (CAAF) has emerged as an effective treatment option of rhythm control for patients with symptomatic AF. However, the risk of thromboembolism and bleeding in the periprocedural period represent a worrisome complication of this therapy. The reported incidence of thromboembolic and bleeding events associated with CAAF varies from 0.9% to 5% depending on the CAAF strategy and the anticoagulation regimen used in the periprocedural period...
May 5, 2017: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/28471099/watchman-in-ascending-aorta-for-systemic-protection-waasp-novel-use-of-watchman-in-ascending-aorta-for-embolic-protection-first-in-man
#20
Pradeep K Yadav, Dee Dee Wang, Marvin H Eng, William W O'Neill
We report two cases where left atrial appendage closure (LAA) with Watchman was successfully performed despite presence of definite LAA thrombus. Because there was the risk of thrombus dislodgement, we transiently placed an additional Watchman device in the ascending aorta for embolic protection. © 2017 Wiley Periodicals, Inc.
May 4, 2017: Catheterization and Cardiovascular Interventions
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