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https://www.readbyqxmd.com/read/28930824/evaluating-the-morphology-of-the-left-atrial-appendage-by-a-transesophageal-echocardiographic-3-dimensional-printed-model
#1
Hongning Song, Qing Zhou, Lan Zhang, Qing Deng, Yijia Wang, Bo Hu, Tuantuan Tan, Jinling Chen, Yiteng Pan, Fazhi He
The novel 3-dimensional printing (3DP) technique has shown its ability to assist personalized cardiac intervention therapy. This study aimed to determine the feasibility of 3D-printed left atrial appendage (LAA) models based on 3D transesophageal echocardiography (3D TEE) data and their application value in treating LAA occlusions.Eighteen patients with transcatheter LAA occlusion, and preprocedure 3D TEE and cardiac computed tomography were enrolled. 3D TEE volumetric data of the LAA were acquired and postprocessed for 3DP...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28924113/the-evaluation-of-interstitial-abnormalities-in-group-b-of-the-2011-global-initiative-for-chronic-obstructive-lung-disease-gold-classification-of-chronic-obstructive-pulmonary-disease-copd
#2
Masahiro Ohgiya, Hirotoshi Matsui, Atsuhisa Tamura, Takafumi Kato, Shinobu Akagawa, Ken Ohta
Objective In 2011, the Global Initiative for Chronic Obstructive Lung Disease (GOLD) classification categorized chronic obstructive pulmonary disease (COPD) patients into 4 groups. A report demonstrated that the mortality in Group B was higher than that in Group C. Ischemic heart disease and cancer were suggested to be the cause. The aim of the present study was to test the hypothesis that interstitial lung abnormalities (ILAs) are more prevalent in Group B than Group C and that they may be responsible for the higher mortality in Group B...
September 15, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28914200/development-of-peptide-vaccines-in-dengue
#3
Kavita Reginald, Yanqi Chan, Magdalena Plebanski, Chit Laa Poh
Dengue is one of the most important arboviral infection worldwide, infecting up to 390 million people and causing 25,000 deaths annually. Although a licensed dengue vaccine is available, it is not efficacious against dengue serotypes that infect people living in South East Asia, where dengue is an endemic disease. Hence, there is an urgent need to develop an efficient dengue vaccine for this region. Data from different clinical trials indicate that a successful dengue vaccine must elicit both neutralizing antibodies and cell mediated immunity...
September 13, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28911063/stromal-lymphocyte-infiltration-after-neoadjuvant-chemotherapy-is-associated-with-aggressive-residual-disease-and-lower-disease-free-survival-in-her2-positive-breast-cancer
#4
A-S Hamy, J-Y Pierga, A Sabaila, E Laas, H Bonsang-Kitzis, C Laurent, A Vincent-Salomon, P Cottu, F Lerebours, R Rouzier, M Lae, F Reyal
Background: The role of tumor-infiltrating lymphocytes (TILs) in breast cancer has been extensively studied over the last decade. High TILs levels have been associated with pathological response rate in the neoadjuvant setting and with better outcomes in the adjuvant setting. However, little attention has been paid to changes in TILs and residual TIL levels after neoadjuvant chemotherapy (NAC). We investigated TIL levels before, after chemotherapy, and their dynamics during treatment; and we assessed the correlation of these levels with response to NAC and prognosis...
September 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28898453/echocardiographic-guidance-and-monitoring-of-left-atrial-appendage-closure-with-atriclip-during-open-chest-cardiac-surgery
#5
Rachele Contri, Sara Clivio, Tiziano Torre, Tiziano Cassina
Left atrial appendage (LAA) closure prevents thromboembolic risk and avoids lifelong anticoagulation due to atrial fibrillation (AF). Nowadays, AtriClip, a modern epicardial device approved in June 2010, allows external and safe closure of LAA in patients undergoing cardiac surgery during other open-chest cardiac surgical procedures. Such a surgical approach and its epicardial deployment differentiates LAA closure with AtriClip from percutaneous closure techniques such as Watchman (Boston Scientific, Marlborough, MA, USA), Lariat (SentreHEART Inc...
September 12, 2017: Echocardiography
https://www.readbyqxmd.com/read/28887807/feasibility-of-multiplane-microtransoesophageal-echocardiographic-guidance-in-structural-heart-disease-transcatheter-interventions-in-adults
#6
V J Nijenhuis, A Alipour, N C Wunderlich, B J W M Rensing, G Gijsbers, J M Ten Berg, M J Suttorp, L V A Boersma, J A S van der Heyden, M J Swaans
INTRODUCTION: Structural heart interventions are guided by transoesophageal or intracardiac echocardiography (TEE/ICE). MicroTEE, developed for paediatric purposes, is smaller and therefore less invasive and traumatic, avoiding the need for general anaesthesia. We aimed to show feasibility of procedural guidance by comparing image quality of microTEE with standard TEE and ICE during adult transcatheter interventions, and assess the accuracy in obtaining left atrial appendage (LAA) measurements between the microTEE probe and standard TEE...
September 8, 2017: Netherlands Heart Journal
https://www.readbyqxmd.com/read/28882323/left-atrial-appendage-closure-for-prevention-of-death-stroke-and-bleeding-in-patients-with-nonvalvular-atrial-fibrillation
#7
Steffen Gloekler, Jacqueline Saw, Konstantinos C Koskinas, Caroline Kleinecke, Werner Jung, Fabian Nietlispach, Bernhard Meier
Nonvalvular atrial fibrillation (AF) is the most frequent arrhythmia with a prevalence of 1%-2% in the general population. Its prevalence increases with age and its diagnosis benefits of improvement and simplification of technologies for its detection. Today, AF affects approximately 7% of individuals age>65years and 15%-20% of octogenarians. Due to stasis and activation of coagulation in a fibrillating atrium, patients are at increased risk of thromboembolism, in particular ischemic stroke, with an overall stroke risk of 5% per year...
August 26, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28881765/mitral-isthmus-ablation-using-a-circular-mapping-catheter-positioned-in-the-left-atrial-appendage-as-a-reference-for-conduction-block
#8
Takahiko Nishiyama, Takehiro Kimura, Taishi Fujisawa, Kazuaki Nakajima, Akira Kunitomi, Shin Kashimura, Yoshinori Katsumata, Nobuhiro Nishiyama, Yoshiyasu Aizawa, Keiichi Fukuda, Seiji Takatsuki
BACKGROUND: For perimitral atrial flutter (PMFL) developing after catheter ablation of atrial fibrillation (AF), to create a complete conduction block at the mitral isthmus (MI) is mandatory to terminate it, however, it is still challenging. METHODS: This study consisted of 80 patients (74 male, 61 ± 8.1 years) undergoing MI ablation. After a circular mapping catheter was positioned at the neck of the left atrial appendage (LAA), the MI ablation was performed on the MI line just below the LAA neck targeting the earliest activation recording site of the LAA catheter during pacing from the coronary sinus (CS)...
August 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28879526/intracardiac-echocardiography-for-structural-heart-and-electrophysiological-interventions
#9
REVIEW
Craig Basman, Yuvrajsinh J Parmar, Itzhak Kronzon
PURPOSE OF REVIEW: With an increasing number of interventional procedures performed for structural heart disease and cardiac arrhythmias each year, echocardiographic guidance is necessary for safe and efficient results. The purpose of this review article is to overview the principles of intracardiac echocardiography (ICE) and describes the peri-interventional role of ICE in a variety of structural heart disease and electrophysiological interventions. RECENT FINDINGS: Both transthoracic (TTE) and transesophageal echocardiography have limitations...
September 6, 2017: Current Cardiology Reports
https://www.readbyqxmd.com/read/28877379/short-term-safety-and-efficacy-of-left-atrial-appendage-closure-with-the-watchman-device-in-patients-with-small-left-atrial-appendage-ostia
#10
Ganesh Venkataraman, S Adam Strickberger, Shephal Doshi, Christopher Ellis, Dhanunjaya Lakkireddy, S Patrick Whalen, Frank Cuoco
INTRODUCTION: Left atrial appendage (LAA) closure with the WATCHMAN device, according to FDA labelling, is recommended in patients with a maximal LAA ostial width between 17-31 mm. The safety and efficacy of LAA closure in patients with a maximal LAA ostial width < 17 mm has not been evaluated. The goal of this study was to determine the acute and short-term safety and efficacy of LAA closure with the WATCHMAN device in patients with a maximal LAA ostial width < 17 mm. METHODS AND RESULTS: Thirty-two consecutive patients with a maximal LAA ostial width < 17 mm as determined by a screening transesophageal echocardiogram (TEE) underwent LAA closure with the WATCHMAN device between March 2015 and November 2016 at five medical centers, and were included in this study...
September 6, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28873081/impact-of-tag-single-nucleotide-polymorphisms-snps-in-ccl11-gene-on-risk-of-subtypes-of-ischemic-stroke-in-xinjiang-han-populations
#11
Chen Liang, Guihua Ni, Jianhua Ma, Hai Liu, Zhifeng Mao, Honggang Sun, Xiaoning Zhang
BACKGROUND CCL11 is an important inflammatory cytokine associated with inflammation-related diseases such as atherosclerosis and stroke. The aim of this study was to investigate the relationship between CCL11 gene polymorphism with subtypes of ischemic stroke in Xinjiang Han populations. MATERIAL AND METHODS The improved multiple ligase detection reaction (iMLDR) method was used to analyze the genotypes of 6 tag SNPs in the CCL11 gene (rs1129844, rs17809012, rs1860183, rs1860184, rs4795898, and rs4795895) in a case-control study of 406 lacunar stroke patients, 214 large-artery atherosclerotic (LAA) stroke patients, and 425 controls...
September 5, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28870655/comparative-health-effects-in-mice-of-libby-amphibole-asbestos-and-a-fibrous-amphibole-from-arizona
#12
Jean C Pfau, Brenda Buck, Rodney V Metcalf, Zoie Kaupish, Caleb Stair, Maria Rodriguez, Deborah E Keil
This project developed from studies demonstrating that Libby Amphibole Asbestos (LAA) causes a non-typical set of health outcomes not generally reported for asbestos, including systemic autoimmunity and an unusual and devastating lamellar pleural thickening that progresses to severe pulmonary dysfunction and death. Further, mineral fiber mixtures with some similarities to LAA have recently been discovered in southern Nevada and northwestern Arizona, where the material exists in extensive recreational areas and is present in yards, roads, parking lots and school yards...
September 7, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28870546/association-of-saa-gene-polymorphism-with-ischemic-stroke-in-northern-chinese-han-population
#13
Jie Zhao, Xiangyu Piao, Yue Wu, Ping Xu, Zhiyi He
BACKGROUND: Serum amyloid A protein (SAA) is known as an inflammatory factor and an apolipoprotein that can replace apolipoprotein A-I/II components as the major apolipoprotein of high-density lipoprotein (HDL), which is related to atherosclerosis. The present study is aimed to evaluate whether the SAA gene polymorphism is involved in ischemic stroke in northern Chinese Han population. METHODS: In a case-control study, the participants included 396 patients (239 males, 157 females) with ischemic stroke and 360 healthy subjects (211 males, 149 females)...
September 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28864464/use-of-the-cha2ds2vasc-score-to-reduce-utilisation-of-transoesophageal-echocardiography-prior-to-ablation-for-atrial-fibrillation
#14
Charlotte Atkinson, Jonathan Hinton, Edmund B Gaisie, Arthur M Yue, Paul R Roberts, Dhrubo J Rakhit, Benoy N Shah
Trans-oesophageal echocardiography (TOE) is frequently performed prior to atrial fibrillation (AF) ablation to exclude left atrial appendage (LAA) thrombus. However, patients undergoing AF ablation are usually anticoagulated, thus making the presence of thrombus unlikely in most cases. This study aimed to determine whether the CHA2DS2VASc scoring system can be used to identify patients that do not require TOE prior to AF ablation. In this single centre retrospective study, local institutional and primary care databases and electronic patient records were searched to identify patients that had undergone TOE prior to AF ablation...
September 1, 2017: Echo Research and Practice
https://www.readbyqxmd.com/read/28862376/rationale-and-design-of-a-global-registry-to-evaluate-real-world-clinical-outcomes-in-patients-with-atrial-fibrillation-and-high-risk-of-stroke-treated-with-left-atrial-appendage-occlusion-using-the-amplatzer-amulet-device-perspective-of-available-ongoing-registries
#15
David Hildick-Smith, Hans-Christoph Diener, Boris Schmidt, Vincent Paul, Magnus Settergren, Emmanuel Teiger, John Camm, Claudio Tondo, Ulf Landmesser
OBJECTIVES: To describe the rationale and design of a global prospective registry on catheter-based left atrial appendage (LAA) occlusion using the second generation AMPLATZER Amulet LAA occlusion device and to provide a comprehensive perspective on available/ongoing registries for catheter-based LAA occlusion. BACKGROUND: Given the increasing clinical application of catheter-based LAA occlusion, there is an important need for prospective real-world clinical data regarding this cardiac intervention...
September 1, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28844546/etiological-classification-of-stroke-in-patients-with-chagas-disease-using-toast-causative-classification-system-toast-and-ascod-phenotyping
#16
Rodrigo de Paiva Bezerra, Maramélia Araújo de Miranda Alves, Adriana Bastos Conforto, Daniela Laranja Gomes Rodrigues, Gisele Sampaio Silva
BACKGROUND: Cardioembolism is considered a major pathophysiological mechanism in patients with ischemic stroke (IS) and Chagas disease (CD). However, a previous study reported that other stroke subtypes are present in more than 40% of CD patients according to the TOAST classification. Therefore, the aim of our study was to evaluate the etiologic classification of stroke in patients with CD using the Causative Classification System (CCS), the ASCOD, and the TOAST classifications in a prospective cohort of patients...
August 22, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28843428/association-of-matrix-metalloproteinase-3-gene-5a-6a-polymorphism-with-the-recurrence-of-ischemic-stroke-a-prospective-observational-study
#17
Xiaoya Huang, Qiang Ye, Zheng Zhang, Xiangdong Huang, Zhenguo Zhu, Yanyan Chen, Jia Li, Siyan Chen, Niange Xia, Xinlei Mao, Liya Han, Zusen Ye
Studies have demonstrated that matrix metalloproteinase-3 (MMP-3) is involved in the development and progression of atherosclerosis. However, there is no information available on the association of MMP-3 5A/6A polymorphism with recurrent ischemic stroke (IS) in different IS subtypes. We investigated the potential associations between MMP-3 serum level and -1171 5A/6A polymorphism and the recurrence of IS in a Chinese population. Consecutive acute first-ever IS patients were enrolled between August 2008 and October 2013...
August 23, 2017: Brain Research
https://www.readbyqxmd.com/read/28841251/procedural-findings-and-ablation-outcome-in-patients-with-atrial-fibrillation-referred-after-two-or-more-failed-catheter-ablations
#18
Sanghamitra Mohanty, Chintan Trivedi, Carola Gianni, Domenico Giovanni Della Rocca, Eli Hamilton Morris, J David Burkhardt, Javier E Sanchez, Rodney Horton, G Joseph Gallinghouse, Richard Hongo, Salwa Beheiry, Amin Al-Ahmad, Luigi Di Biase, Andrea Natale
INTRODUCTION: This study reports the procedural findings and ablation outcome in AF patients referred after ≥2 failed PV isolation (PVI). METHODS: Three hundred and five consecutive AF patients referred after ≥2 PVI were included in the analysis. High-dose isoproterenol challenge was used to identify PV reconnection and non-PV triggers; the latter were ablated based on the operator's discretion during the index procedure. At the repeat procedure, non-PV triggers were ablated in all...
August 25, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28840592/left-atrial-appendage-closure-for-primary-primary-prevention-during-percutaneous-closure-of-septal-defects-in-patients-with-large-atria-but-no-atrial-fibrillation
#19
Shingo Kuwata, Juliane Vierecke, Steffen Gloekler, Francesco Maisano, Bernhard Meier, Fabian Nietlispach
BACKGROUND: Percutaneous atrial septal defect (ASD) closure is a routine procedure to prevent right ventricular failure, pulmonary hypertension, or paradoxical embolism. The latter is the typical reason for percutaneous patent foramen ovale (PFO) closure. Atrial enlargement represents a risk for developing atrial fibrillation (AF). Percutaneous left atrial appendage (LAA) closure is emerging as a preventive therapy for patients in AF who suffered from a previous stroke or bleeding (secondary prevention) or patients without previous stroke or bleeding (primary prevention)...
August 25, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/28836342/single-trans-septal-access-technique-for-left-atrial-intracardiac-echocardiography-to-guide-left-atrial-appendage-closure
#20
Daniel Aguirre, Christian Pincetti, Luis Perez, Carlos Deck, Mario Alfaro, Maria Jesus Vergara, Gabriel Maluenda
OBJECTIVE: This registry aimed to describe the safety and feasibility of a single trans-septal (TS) access technique for left intracardiac echocardiography (ICE) guidance of left-atrial appendage (LAA) closure procedure. BACKGROUND: LAA closure is currently accepted as an alternative to oral anticoagulation (OAC) in patients with non-valvular atrial fibrillation (NVAF) who are at high-risk for bleeding. Currently, LAA closure procedure is typically performed under trans-esophageal echocardiogram (TEE) guidance...
August 24, 2017: Catheterization and Cardiovascular Interventions
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