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Electro physiology

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https://www.readbyqxmd.com/read/27918346/electrical-stimulation-for-seizure-induction-and-functional-mapping-in-stereoelectroencephalography
#1
Agnès Trébuchon, Patrick Chauvel
The challenge in epilepsy surgery is to remove the epileptogenic zone without compromising postoperative function. Electrical stimulation (ES) was developed to identify with greater anatomical and physiological precision cortical structures essential to language and motor function. Because the language network is widely distributed in the left (dominant) hemisphere, and often varies among patients, brain mapping should delineate eloquent areas at the individual level. Although ES for language is commonly performed during a presurgical investigation, the procedure remains nonstandardized among centers, and differences between grids and intracerebral depth electrodes (stereoelectroencephalography) should be taken into account when comparing results from different series...
December 2016: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
https://www.readbyqxmd.com/read/27913147/electro-kinetically-driven-peristaltic-transport-of-viscoelastic-physiological-fluids-through-a-finite-length-capillary-mathematical-modelling
#2
Dharmendra Tripathi, Ashu Yadav, O Anwar Bég
Analytical solutions are developed for the electro-kinetic flow of a viscoelastic biological liquid in a finite length cylindrical capillary geometry under peristaltic waves. The Jefferys' non-Newtonian constitutive model is employed to characterize rheological properties of the fluid. The unsteady conservation equations for mass and momentum with electro-kinetic and Darcian porous medium drag force terms are reduced to a system of steady linearized conservation equations in an axisymmetric coordinate system...
November 29, 2016: Mathematical Biosciences
https://www.readbyqxmd.com/read/27883074/adipose-stem-cells-display-higher-regenerative-capacities-and-more-adaptable-electro-kinetic-properties-compared-to-bone-marrow-derived-mesenchymal-stromal-cells
#3
Ahmed El-Badawy, Marwa Amer, Reda Abdelbaset, Sameh N Sherif, Marwan Abo-Elela, Yehya H Ghallab, Hamdy Abdelhamid, Yehea Ismail, Nagwa El-Badri
Adipose stem cells (ASCs) have recently emerged as a more viable source for clinical applications, compared to bone-marrow mesenchymal stromal cells (BM-MSCs) because of their abundance and easy access. In this study we evaluated the regenerative potency of ASCs compared to BM-MSCs. Furthermore, we compared the dielectric and electro-kinetic properties of both types of cells using a novel Dielectrophoresis (DEP) microfluidic platform based on a printed circuit board (PCB) technology. Our data show that ASCs were more effective than BM-MSCs in promoting neovascularization in an animal model of hind-limb ischemia...
November 24, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27881667/a-mechanistic-physicochemical-model-of-carbon-dioxide-transport-in-blood
#4
David Patrick O'Neill, Peter A Robbins
A number of mathematical models have been produced that, given the Pco2 and Po2 of blood, will calculate the total concentrations for CO2 and O2 in blood. However, all these models contain at least some empirical features, and thus do not represent all of the underlying physicochemical processes in an entirely mechanistic manner. The aim of this study was to develop a physicochemical model of CO2 carriage by the blood to determine whether our understanding of the physical chemistry of the major chemical components of blood together with their interactions is sufficiently strong to predict the physiological properties of CO2 carriage by whole blood...
November 23, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27858026/a-portable-microfluidic-system-for-rapid-measurement-of-the-erythrocyte-sedimentation-rate
#5
Ziya Isiksacan, Ozcan Erel, Caglar Elbuken
The erythrocyte sedimentation rate (ESR) is a frequently used 30 min or 60 min clinical test for screening of several inflammatory conditions, infections, trauma, and malignant diseases, as well as non-inflammatory conditions including prostate cancer and stroke. Erythrocyte aggregation (EA) is a physiological process where erythrocytes form face-to-face linear structures, called rouleaux, at stasis or low shear rates. In this work, we proposed a method for ESR measurement from EA. We developed a microfluidic opto-electro-mechanical system, using which we experimentally showed a significant correlation (R(2) = 0...
November 18, 2016: Lab on a Chip
https://www.readbyqxmd.com/read/27783269/anion-channels-of-mitochondria
#6
Devasena Ponnalagu, Harpreet Singh
Mitochondria are the "power house" of a cell continuously generating ATP to ensure its proper functioning. The constant production of ATP via oxidative phosphorylation demands a large electrochemical force that drives protons across the highly selective and low-permeable mitochondrial inner membrane. Besides the conventional role of generating ATP, mitochondria also play an active role in calcium signaling, generation of reactive oxygen species (ROS), stress responses, and regulation of cell-death pathways...
October 26, 2016: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/27762540/electro-photodynamic-visualization-of-singlet-oxygen-induced-by-zinc-porphyrin-modified-microchip-in-aqueous-media
#7
Chuanguang Yao, Hongxin Song, Ying Wan, Kefeng Ma, Chenyu Zheng, Hongda Cui, Peng Xin, Xubo Ji, Sheng-Yuan Deng
A porphyrin-based electro-photodynamic imaging system was fabricated for monitoring the concentration of oxygen. Distinct from the electrochemiluminescent (ECL) inability of numerous organic species in aqueous solutions, a strong and stable red irradiation at 634 nm could be stimulated electrochemically on zinc(II) meso-tetra(4-carboxyphenyl) porphine (ZnTCPP)/tetraoctylammonium bromide (TOAB) in the physiological condition. In terms of in situ electron paramagnetic resonance and ECL spectroscopies, the nature of ECL was thoroughly investigated, being exactly the chemiluminescence from singlet oxygen (1O2) produced during the successive electro-reduction of ZnTCPP...
October 20, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27664111/electro-physiological-changes-in-the-brain-induced-by-caffeine-or-glucose-nasal-spray
#8
K De Pauw, B Roelands, J Van Cutsem, U Marusic, T Torbeyns, R Meeusen
OBJECTIVE: A direct link between the mouth cavity and the brain for glucose (GLUC) and caffeine (CAF) has been established. The aim of this study is to determine whether a direct link for both substrates also exist between the nasal cavity and the brain. METHODS: Ten healthy male subjects (age 22 ± 1 years) performed three experimental trials, separated by at least 2 days. Each trial included a 20-s nasal spray (NAS) period in which solutions placebo (PLAC), GLUC, or CAF were provided in a double-blind, randomized order...
September 23, 2016: Psychopharmacology
https://www.readbyqxmd.com/read/27642859/the-effect-of-game-design-goal-type-and-player-numbers-on-the-physiological-and-physical-demands-of-hurling-specific-small-sided-games
#9
Shane Malone, Kieran Collins
The current study examined the effect that game design modification, goal type and player numbers on the running performance and physiological demands of small-sided hurling games (SSG). Forty-eight hurling players (age 25.5 ± 3.2 years; height 178.9 ± 3.2 cm; body mass 78.5 ± 4.5 kg) performed four types of SSG (possession (P), normal play (NP), regular Goals (RG) and small goals (SG) in four-a-side, five-a-side and six-a-side formats. Heart rate (Polar Electro Oy, Kempele, Finland) and Global positioning system technology (VX Sport, 4-Hz, Lower Hutt, New Zealand) were used to analyse the physical and physiological differences between SSG...
September 6, 2016: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/27612722/poly-dopamine-beta-cyclodextrin-a-novel-nanobiopolymer-towards-sensing-of-some-amino-acids-at-physiological-ph
#10
Mohammad Hasanzadeh, Sattar Sadeghi, Leyla Bageri, Ahad Mokhtarzadeh, Ayub Karimzadeh, Nasrin Shadjou, Soltanali Mahboob
A novel nanobiopolymer film was electrodeposited on the surface of glassy carbon through cyclic voltammetry from dopamine, β-cyclodextrin, and phosphate buffer solution in physiological pH (7.40). The electrochemical behavior of polydopamine-Beta-cyclodextrin modified glassy carbon electrode was investigated for electro-oxidation and determination of some amino acids (l-Cysteine, l-Tyrosine, l-Glycine, and l-Phenylalanine). The modified electrode was applied for selected amino acid detection at physiological pH using cyclic voltammetry, differential pulse voltammetry and chronoamperometry, chronocoulometery...
December 1, 2016: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27595330/small-molecule-wnk-inhibition-regulates-cardiovascular-and-renal-function
#11
Ken Yamada, Hyi-Man Park, Dean F Rigel, Keith DiPetrillo, Erin J Whalen, Anthony Anisowicz, Michael Beil, James Berstler, Cara Emily Brocklehurst, Debra A Burdick, Shari L Caplan, Michael P Capparelli, Guanjing Chen, Wei Chen, Bethany Dale, Lin Deng, Fumin Fu, Norio Hamamatsu, Kouki Harasaki, Tracey Herr, Peter Hoffmann, Qi-Ying Hu, Waan-Jeng Huang, Neeraja Idamakanti, Hidetomo Imase, Yuki Iwaki, Monish Jain, Jey Jeyaseelan, Mitsunori Kato, Virendar K Kaushik, Darcy Kohls, Vidya Kunjathoor, Daniel LaSala, Jongchan Lee, Jing Liu, Yang Luo, Fupeng Ma, Ruowei Mo, Sarah Mowbray, Muneto Mogi, Flavio Ossola, Pramod Pandey, Sejal J Patel, Swetha Raghavan, Bahaa Salem, Yuka H Shanado, Gary M Trakshel, Gordon Turner, Hiromichi Wakai, Chunhua Wang, Stephen Weldon, Jennifer B Wielicki, Xiaoling Xie, Lingfei Xu, Yukiko I Yagi, Kayo Yasoshima, Jianning Yin, David Yowe, Ji-Hu Zhang, Gang Zheng, Lauren Monovich
The With-No-Lysine (K) (WNK) kinases play a critical role in blood pressure regulation and body fluid and electrolyte homeostasis. Herein, we introduce the first orally bioavailable pan-WNK-kinase inhibitor, WNK463, that exploits unique structural features of the WNK kinases for both affinity and kinase selectivity. In rodent models of hypertension, WNK463 affects blood pressure and body fluid and electro-lyte homeostasis, consistent with WNK-kinase-associated physiology and pathophysiology.
November 2016: Nature Chemical Biology
https://www.readbyqxmd.com/read/27594831/method-for-improving-eeg-based-emotion-recognition-by-combining-it-with-synchronized-biometric-and-eye-tracking-technologies-in-a-non-invasive-and-low-cost-way
#12
Juan-Miguel López-Gil, Jordi Virgili-Gomá, Rosa Gil, Roberto García
Technical advances, particularly the integration of wearable and embedded sensors, facilitate tracking of physiological responses in a less intrusive way. Currently, there are many devices that allow gathering biometric measurements from human beings, such as EEG Headsets or Health Bracelets. The massive data sets generated by tracking of EEG and physiology may be used, among other things, to infer knowledge about human moods and emotions. Apart from direct biometric signal measurement, eye tracking systems are nowadays capable of determining the point of gaze of the users when interacting in ICT environments, which provides an added value research on many different areas, such as psychology or marketing...
2016: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/27590776/a-two-variable-model-robust-to-pacemaker-behaviour-for-the-dynamics-of-the-cardiac-action-potential
#13
Cesare Corrado, Steven A Niederer
Ionic models with two state variables are routinely used in patient specific electro-physiology simulations due to the small number of parameters to be constrained and their computational tractability. Among these models, the Mitchell and Schaeffer (MS) action potential model is often used in ventricle electro-physiology due to its ability to reproduce the shape of the action potential and its restitution properties. However, for some choices of parameters characterising this ionic model, unwanted pacemaker behaviour is present...
November 2016: Mathematical Biosciences
https://www.readbyqxmd.com/read/27579490/involvement-of-cx3cl1-in-the-migration-of-osteoclast-precursors-across-osteoblast-layer-stimulated-by-interleukin-1%C3%A3
#14
Tsuyoshi Matsuura, Shizuko Ichinose, Masako Akiyama, Yuki Kasahara, Noriko Tachikawa, Ken-Ichi Nakahama
The trigger for bone remodeling is bone resorption by osteoclasts. Osteoclast differentiation only occurs on the old bone, which needs to be repaired under physiological conditions. However, uncontrolled bone resorption is often observed in pro-inflammatory bone diseases, such as rheumatoid arthritis. Mature osteoclasts are multinuclear cells that differentiate from monocyte/macrophage lineage cells by cell fusion. Although Osteoclast precursors should migrate across osteoblast layer to reach bone matrix before maturation, the underlying mechanisms have not yet been elucidated in detail...
August 31, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27570953/-emotional-memory-and-electrocortical-activity-in-schizophrenia
#15
Marc E Lavoie, Julie Champagne, Emma Glaser, Adrianna Mendrek
Context Abnormal emotion processing is frequent in schizophrenia and affects social and functional outcome. Past event-related potential (ERP) research investigating processing of affective stimuli in schizophrenia was done mainly with facial expressions and revealed impaired facial emotion recognition in patients relative to control subjects. Experimentations involving fMRI with this group of patients, showed alteration of limbic and frontal regions in response to emotional unpleasant images, compared to neutral stimuli during a memory task...
2016: Santé Mentale Au Québec
https://www.readbyqxmd.com/read/27570648/ion-channel-electrophysiology-ontology-icepo-a-case-study-of-text-mining-assisted-ontology-development
#16
Ravikumar Komandur Elayavilli, Hongfang Liu
BACKGROUND: Computational modeling of biological cascades is of great interest to quantitative biologists. Biomedical text has been a rich source for quantitative information. Gathering quantitative parameters and values from biomedical text is one significant challenge in the early steps of computational modeling as it involves huge manual effort. While automatically extracting such quantitative information from bio-medical text may offer some relief, lack of ontological representation for a subdomain serves as impedance in normalizing textual extractions to a standard representation...
2016: AMIA Summits on Translational Science Proceedings
https://www.readbyqxmd.com/read/27567400/an-electro-mechanical-multiscale-model-of-uterine-pregnancy-contraction
#17
Maxime Yochum, Jérémy Laforêt, Catherine Marque
Detecting preterm labor as early as possible is important because tocolytic drugs are much more likely to delay preterm delivery if administered early. Having good information on the real risk of premature labor also leads to fewer women who do not need aggressive treatment for premature labor threat. Currently, one of the most promising ways to diagnose preterm labor threat is the analysis of the electrohysterogram (EHG). Its characteristics have been related to preterm labor risk but they have not proven to be sufficiently accurate to use in clinical routine...
October 1, 2016: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/27562096/treatment-of-autistic-spectrum-disorder-with-insulin-like-growth-factors
#18
Raili Riikonen
There are no treatments for the core symptoms of autistic spectrum disorder (ASD), but there is now more knowledge on emerging mechanisms and on mechanism-based therapies. In autism there are altered synapses: genes affected are commonly related to synaptic and immune function. Dysregulation of activity-dependent signaling networks may have a key role the etiology of autism. There is an over-activation of IGF-AKT-mTor in autism spectrum disorders. Morphological and electro-physiological defects of the cerebellum are linked to system-wide ASD-like behavior defects...
December 0: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/27551107/noncovalent-forces-tune-the-electron-transfer-complex-between-ferredoxin-and-sulfite-reductase-to-optimize-enzymatic-activity
#19
Ju Yaen Kim, Misaki Kinoshita, Satoshi Kume, Hanke Guy Tomas, Toshihiko Sugiki, John E Ladbury, Chojiro Kojima, Takahisa Ikegami, Genji Kurisu, Yuji Goto, Toshiharu Hase, Young-Ho Lee
ALTHOUGH ELECTROSTATIC INTERACTIONS BETWEEN NEGATIVELY-CHARGED FERREDOXIN FD AND POSITIVELY-CHARGED SULFITE REDUCTASE SIR HAVE BEEN PREDOMINANTLY HIGHLIGHTED TO CHARACTERIZE COMPLEX FORMATION, THE DETAILED NATURE OF INTERMOLECULAR FORCES REMAINS TO BE FULLY ELUCIDATED : WE HEREIN INVESTIGATED INTERPROTEIN FORCES FOR FORMATION OF AN ELECTRON-TRANSFER COMPLEX BETWEEN FD AND SIR AND THEIR RELATIONSHIP TO SIR ACTIVITY USING VARIOUS APPROACHES OVER NACL CONCENTRATIONS BETWEEN 0 AND 400 MM : FD-DEPENDENT SIR ACTIVITY ASSAYS REVEALED A BELL-SHAPED ACTIVITY CURVE WITH A MAXIMUM AROUND 40-70 MM NACL AND A REVERSE BELL-SHAPED DEPENDENCE OF INTERPROTEIN AFFINITY MEANWHILE, INTRINSIC SIR ACTIVITY, AS MEASURED IN A METHYL VIOLOGEN-DEPENDENT ASSAY, EXHIBITED SATURATION ABOVE 100 MM NACL THUS, TWO ASSAYS SUGGESTED THAT INTERPROTEIN INTERACTION IS CRUCIAL IN CONTROLLING FD-DEPENDENT SIR ACTIVITY : CALORIMETRIC ANALYSES SHOWED THE MONOTONIC DECREASE IN INTERPROTEIN AFFINITY ON INCREASING NACL CONCENTRATIONS, DISTINGUISHED : FROM : A REVERSE BELL-SHAPED INTERPROTEIN AFFINITY: OBSERVED FROM FD-DEPENDENT SIR ACTIVITY ASSAY: : FURTHERMORE, FDSIR COMPLEX FORMATION AND INTERPROTEIN AFFINITY WERE THERMODYNAMICALLY ADJUSTED BY BOTH ENTHALPY AND ENTROPY THROUGH ELECTROSTATIC AND NON-ELECTROSTATIC INTERACTIONS A RESIDUE-BASED NMR INVESTIGATION ON ADDITION OF SIR TO 15N-LABELED FD AT THE VARIOUS NACL CONCENTRATION ALSO DEMONSTRATED THAT A COMBINATION OF ELECTRO- AND NON-ELECTROSTATIC FORCES STABILIZED THE COMPLEX WITH SIMILAR INTERFACES AND MODULATED THE BINDING AFFINITY AND MODE : OUR FINDINGS ELUCIDATE THAT NON-ELECTROSTATIC FORCES ARE ALSO ESSENTIAL FOR THE FORMATION AND MODULATION OF THE FDSIR COMPLEX WE SUGGEST THAT A COMPLEX CONFIGURATION OPTIMIZED FOR MAXIMUM ENZYMATIC ACTIVITY NEAR PHYSIOLOGICAL SALT CONDITIONS IS ACHIEVED BY STRUCTURAL REARRANGEMENT THROUGH CONTROLLED NON-COVALENT INTERPROTEIN INTERACTIONS...
August 22, 2016: Biochemical Journal
https://www.readbyqxmd.com/read/27494699/modulatory-effects-of-sex-steroids-progesterone-and-estradiol-on-odorant-evoked-responses-in-olfactory-receptor-neurons
#20
Ninthujah Kanageswaran, Maximilian Nagel, Paul Scholz, Julia Mohrhardt, Günter Gisselmann, Hanns Hatt
The influence of the sex steroid hormones progesterone and estradiol on physiology and behavior during menstrual cycles and pregnancy is well known. Several studies indicate that olfactory performance changes with cyclically fluctuating steroid hormone levels in females. Knowledge of the exact mechanisms behind how female sex steroids modulate olfactory signaling is limited. A number of different known genomic and non-genomic actions that are mediated by progesterone and estradiol via interactions with different receptors may be responsible for this modulation...
2016: PloS One
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