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https://www.readbyqxmd.com/read/28406991/a-mathematical-model-for-active-contraction-in-healthy-and-failing-myocytes-and-left-ventricles
#1
Li Cai, Yongheng Wang, Hao Gao, Yiqiang Li, Xiaoyu Luo
Cardiovascular disease is one of the leading causes of death worldwide, in particular myocardial dysfunction, which may lead to heart failure eventually. Understanding the electro-mechanics of the heart will help in developing more effective clinical treatments. In this paper, we present a multi-scale electro-mechanics model of the left ventricle (LV). The Holzapfel-Ogden constitutive law was used to describe the passive myocardial response in tissue level, a modified Grandi-Pasqualini-Bers model was adopted to model calcium dynamics in individual myocytes, and the active tension was described using the Niederer-Hunter-Smith myofilament model...
2017: PloS One
https://www.readbyqxmd.com/read/28397061/a-neural-controller-for-online-laser-power-adjustment-during-the-heat-therapy-process-in-the-presence-of-nanoparticles
#2
S Ehsan Razavi
The present research evaluated the efficiency of a control approach to control the temperature of a breast tumor mass in the presence of nanoparticles exposed to laser radiation. However, if the radiation is carried out in open loop manner it may result in excessive temperature rise healthy cells that exist in the vicinity of tumor's cells. This may lead to the death of healthy cells. So, using closed loop control methods is necessary to guarantee the preservation of healthy cells during the period of radiation...
April 10, 2017: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/28390956/the-structure-of-the-amorphous-matrix-of-keratins
#3
Murat Kadir, Xinwei Wang, Bowen Zhu, Jing Liu, Duane Harland, Crisan Popescu
Various keratin fibers, particularly human hairs, were investigated by transmission electron microscopy, TEM, solid-state 1HNMR and Transient Electro-Thermal Technique, TET. The results converge to suggest that the matrix of keratin fiber cortex, far from being amorphous, has a well-defined nano-scale grainy structure, the size of these grains being around 2 - 4 nm. The size of the grains appears to strongly depend on the chemical treatment of the fiber, on the temperature and on the relative humidity of the environment, as well as on the physiological factors at the level of fiber production in follicle...
April 5, 2017: Journal of Structural Biology
https://www.readbyqxmd.com/read/28372097/automated-setup-for-ex-vivo-larynx-experiments
#4
Veronika Birk, Michael Döllinger, Alexander Sutor, David A Berry, Dominik Gedeon, Maximilian Traxdorf, Olaf Wendler, Christopher Bohr, Stefan Kniesburges
Ex vivo larynx experiments are limited in time due to degeneration of the laryngeal tissues. In order to acquire a significant and comparable amount of data, automatization of current manual experimental procedures is desirable. A computer controlled, electro-mechanical setup was developed for time-dependent variation of specific physiological parameters, including adduction and elongation level of the vocal folds and glottal flow. The setup offers a standardized method to induce defined forces on the laryngeal cartilages...
March 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28342407/music-and-natural-sounds-in-an-auditory-steady-state-response-based-brain-computer-interface-to-increase-user-acceptance
#5
Jeong Heo, Hyun Jae Baek, Seunghyeok Hong, Min Hye Chang, Jeong Su Lee, Kwang Suk Park
Patients with total locked-in syndrome are conscious; however, they cannot express themselves because most of their voluntary muscles are paralyzed, and many of these patients have lost their eyesight. To improve the quality of life of these patients, there is an increasing need for communication-supporting technologies that leverage the remaining senses of the patient along with physiological signals. The auditory steady-state response (ASSR) is an electro-physiologic response to auditory stimulation that is amplitude-modulated by a specific frequency...
March 18, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28334999/rewiring-the-primary-somatosensory-cortex-in-carpal-tunnel-syndrome-with-acupuncture
#6
RANDOMIZED CONTROLLED TRIAL
Yumi Maeda, Hyungjun Kim, Norman Kettner, Jieun Kim, Stephen Cina, Cristina Malatesta, Jessica Gerber, Claire McManus, Rebecca Ong-Sutherland, Pia Mezzacappa, Alexandra Libby, Ishtiaq Mawla, Leslie R Morse, Ted J Kaptchuk, Joseph Audette, Vitaly Napadow
Carpal tunnel syndrome is the most common entrapment neuropathy, affecting the median nerve at the wrist. Acupuncture is a minimally-invasive and conservative therapeutic option, and while rooted in a complex practice ritual, acupuncture overlaps significantly with many conventional peripherally-focused neuromodulatory therapies. However, the neurophysiological mechanisms by which acupuncture impacts accepted subjective/psychological and objective/physiological outcomes are not well understood. Eligible patients (n = 80, 65 female, age: 49...
April 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28277429/the-influence-of-exercise-to-rest-ratios-on-physical-and-physiological-performance-during-hurling-specific-small-sided-games
#7
Shane Malone, Brian Hughes, Kieran Collins
The current study examined the impact of different exercise to rest ratios on hurling specific small-sided games (SSG). Thirty-four (n = 34) hurling players were monitored during an in-season training period. Heart rate (Polar Electro Oy, Kempele, Finland) and global positioning system technology (VX Sport, 4-Hz, Lower Hutt, New Zealand) were used to analyse the physical and physiological differences between exercise to rest ratios across bouts of SSG. Total distance (m) high-speed distance (m) (≥17 km·h), very high-speed distance (≥22 km·h) (m), total accelerations (n), acceleration distance (m), peak velocity (km·h) and % maximum heart rate (%HRmax) were measured...
March 8, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28269050/dictionary-learning-for-sparse-representation-and-classification-of-neural-spikes
#8
Ahmed H Dallal, Yiran Chen, Douglas Weber, Zhi-Hong Mao
Spike sorting is the problem of identifying and clustering neurons spiking activity from recorded extracellular electro-physiological data. This is important for experimental neuroscience. Existing approaches to solve this problem consist of three steps: spike detection, feature extraction, and clustering. In our method, we use Fisher discriminant based dictionary learning to learn dictionary, whose sub-dictionaries are class specific, and estimate discriminative sparse coding coefficients by minimizing the within class scatter and maximizing the between class scatter...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268339/sensing-textile-seam-line-for-wearable-multimodal-physiological-monitoring
#9
M McKnight, T Agcayazi, H Kausche, T Ghosh, A Bozkurt
This paper investigates a novel multimodal sensing method by forming seam-lines of conductive textile fibers into commercially available fabrics. The proposed ultra-low cost micro-electro-mechanical sensor would provide, wearable, flexible, textile based biopotential signal recording, wetness detection and tactile sensing simultaneously. Three types of fibers are evaluated for their array-based sensing capability, including a 3D printed conductive fiber, a multiwall carbon nanotube based fiber, and a commercially available stainless steel conductive thread...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28263770/human-physiological-responses-to-wooden-indoor-environment
#10
Xi Zhang, Zhiwei Lian, Yong Wu
Previous studies are mainly focused on non-wooden environments, whereas few are concerned with wooden ones. How wooden indoor environments impact the physiology of the occupants is still unclear. The purpose of this study was to explore the distinct physiological responses to wooden and non-wooden indoor environments, assessed by physiological parameters tests including blood pressure, electrocardiogram measurements, electro-dermal activity, oxyhemoglobin saturation, skin temperature, and near distance vision...
March 2, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28227266/dictionary-learning-for-sparse-representation-and-classification-of-neural-spikes
#11
Ahmed H Dallal, Yiran Chen, Douglas Weber, Zhi-Hong Mao, Ahmed H Dallal, Yiran Chen, Douglas Weber, Zhi-Hong Mao, Douglas Weber, Zhi-Hong Mao, Yiran Chen, Ahmed H Dallal
Spike sorting is the problem of identifying and clustering neurons spiking activity from recorded extracellular electro-physiological data. This is important for experimental neuroscience. Existing approaches to solve this problem consist of three steps: spike detection, feature extraction, and clustering. In our method, we use Fisher discriminant based dictionary learning to learn dictionary, whose sub-dictionaries are class specific, and estimate discriminative sparse coding coefficients by minimizing the within class scatter and maximizing the between class scatter...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226500/sensing-textile-seam-line-for-wearable-multimodal-physiological-monitoring
#12
M McKnight, T Agcayazi, H Kausche, T Ghosh, A Bozkurt, M McKnight, T Agcayazi, H Kausche, T Ghosh, A Bozkurt, T Ghosh, T Agcayazi, M McKnight, A Bozkurt, H Kausche
This paper investigates a novel multimodal sensing method by forming seam-lines of conductive textile fibers into commercially available fabrics. The proposed ultra-low cost micro-electro-mechanical sensor would provide, wearable, flexible, textile based biopotential signal recording, wetness detection and tactile sensing simultaneously. Three types of fibers are evaluated for their array-based sensing capability, including a 3D printed conductive fiber, a multiwall carbon nanotube based fiber, and a commercially available stainless steel conductive thread...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28183644/facile-preparation-of-poly-methylene-blue-modified-carbon-paste-electrode-for-the-detection-and-quantification-of-catechin
#13
G Manasa, Ronald J Mascarenhas, Ashis K Satpati, Ozma J D'Souza, A Dhason
Free radicals are formed as byproducts of metabolism, and are highly unstable due to the presence of unpaired electrons. They readily react with other important cellular components such as DNA causing them damage. Antioxidants such as (+)-catechin (CAT), neutralize free radicals in the blood stream. Hence there is a need for detection and quantification of catechin concentration in various food sources and beverages. Electro-oxidative properties of catechin were investigated using cyclic voltammetry (CV) and differential pulse voltammetry (DPV)...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28177156/from-maxwell-s-equations-to-the-theory-of-current-source-density-analysis
#14
Sergey L Gratiy, Geir Halnes, Daniel Denman, Michael J Hawrylycz, Christof Koch, Gaute T Einevoll, Costas A Anastassiou
Despite the widespread use of current-source density (CSD) analysis of extracellular potential recordings in the brain, the physical mechanisms responsible for the generation of the signal are still debated. While the extracellular potential is thought to be exclusively generated by the transmembrane currents, recent studies suggest that extracellular diffusive, advective and displacement currents-traditionally neglected-may also contribute considerably toward extracellular potential recordings. Here, we first justify the application of the electro-quasistatic approximation of Maxwell's equations to describe the electromagnetic field of physiological origin...
April 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28168870/annotation-of-functional-impact-of-voltage-gated-sodium-channel-mutations
#15
Valérie Hinard, Aurore Britan, Mathieu Schaeffer, Monique Zahn-Zabal, Urs Thomet, Jean-Sébastien Rougier, Amos Bairoch, Hugues Abriel, Pascale Gaudet
Voltage-gated sodium channels are pore-forming transmembrane proteins that selectively allow sodium ions to flow across the plasma membrane according to the electro-chemical gradient thus mediating the rising phase of action potentials in excitable cells and playing key roles in physiological processes such as neurotransmission, skeletal muscle contraction, heart rhythm, and pain sensation. Genetic variations in the nine human genes encoding these channels are known to cause a large range of diseases affecting the nervous and cardiac systems...
May 2017: Human Mutation
https://www.readbyqxmd.com/read/28123904/cryoelectrolysis-electrolytic-processes-in-a-frozen-physiological-saline-medium
#16
Franco Lugnani, Matteo Macchioro, Boris Rubinsky
BACKGROUND: Cryoelectrolysis is a new minimally invasive tissue ablation surgical technique that combines the ablation techniques of electrolytic ablation with cryosurgery. The goal of this study is to examine the hypothesis that electrolysis can take place in a frozen aqueous saline solution. METHOD: To examine the hypothesis we performed a cryoelectrolytic ablation protocol in which electrolysis and cryosurgery are delivered simultaneously in a tissue simulant made of physiological saline gel with a pH dye...
2017: PeerJ
https://www.readbyqxmd.com/read/28113228/variability-of-ventricular-repolarization-dispersion-quantified-by-time-warping-the-morphology-of-the-t-waves
#17
Julia Ramirez, Michele Orini, Derek Tucker, Esther Pueyo, Pablo Laguna
We propose two electrocardiogram (ECG)-derived markers of T-wave morphological variability in the temporal, dw , and amplitude, da , domains. Two additional markers, d(NL)w and d(NL)a , restricted to measure the non-linear information present within dw and da are also proposed. METHODS: We evaluated the accuracy of the proposed markers in capturing T-wave time and amplitude variations in 3 situations: (1) In a simulated set up with presence of additive Laplacian noise, (2) when modifying the spatio-temporal distribution of electrical repolarization with an electro-physiological cardiac model and (3) in ECG records from healthy subjects undergoing a tilt table test...
October 4, 2016: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28113196/an-electrochemistry-study-of-cryoelectrolysis-in-frozen-physiological-saline
#18
Thomas Manuel, Pujita Munnangi, Boris Rubinsky
Cryoelectrolysis is a new minimally invasive tissue ablation surgical technique that combines the processes of electrolysis and solid/liquid phase transformation (freezing). This study investigated this new technique by measuring the pH front propagation and the changes in resistance in a tissue simulant made of physiological saline gel with a pH dye as a function of the sample temperature in the high subzero range above the eutectic. Results demonstrated that effective electrolysis can occur in a high subzero freezing milieu and that the propagation of the pH front is only weakly dependent on temperature...
December 15, 2016: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28086779/the-effect-of-electrical-conductivity-of-myocardium-on-cardiac-pumping-efficacy-a-computational-study
#19
Ana Rahma Yuniarti, Ki Moo Lim
BACKGROUND AND AIMS: The existence of non-excitable cells in the myocardium leads to the increasing conduction non-uniformity and decreasing myocardial electrical conductivity. Slowed myocardial conduction velocity (MCV) believed to enhance the probability of cardiac arryhthmia and alter the cardiac mechanical pumping efficacy, even in sinus rhythm. Though several studies on the correlation between MCV and cardiac electrical instabilities exist, there has been no study concerning correlation or causality between MCV and cardiac mechanical pumping efficacy, due to the limitation in clinical methods to document and evaluate cardiac mechanical responses directly...
January 10, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28064021/nanosecond-pulsed-electric-field-induced-dose-dependent-phosphatidylinositol-4-5-bisphosphate-signaling-and-intracellular-electro-sensitization
#20
Gleb P Tolstykh, Melissa Tarango, Caleb C Roth, Bennett L Ibey
Previously, it was demonstrated that nanometer-sized pores (nanopores) are formed in outer cellular membranes after exposure to nanosecond electric pulses (nsEPs). We reported that plasma membrane nanoporation affects phospholipids of the cell membrane, culminating in cascading phosphoinositide phosphatidylinositol-4,5-bisphosphate (PIP2) intracellular signaling. In the current study, we show that nsEPs initiated electric field (EF) dose-dependent PIP2 hydrolysis and/or depletion from the plasma membrane. This process was confirmed using fluorescent optical probes of PIP2 hydrolysis: PLCδ-PH-EGFP and GFP-C1-PKCγ-C1a...
January 5, 2017: Biochimica et Biophysica Acta
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