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https://www.readbyqxmd.com/read/29428834/uncensored-eeg-the-role-of-dc-potentials-in-neurobiology-of-the-brain
#1
REVIEW
Stjepana Kovac, Erwin-Josef Speckmann, Ali Gorji
Brain direct current (DC) potentials denote sustained shifts and slow deflections of cerebral potentials superimposed with conventional EEG waves and reflect alterations in the excitation level of the cerebral cortex and subcortical structures. Using galvanometers, such sustained displacement of the EEG baseline was recorded in the early days of electroencephalography. To stabilize the EEG baseline and eliminate artefacts, EEG was performed later by voltage amplifiers with high-pass filters that dismiss slow DC potentials...
February 8, 2018: Progress in Neurobiology
https://www.readbyqxmd.com/read/29425272/endometriosis-alters-brain-electro-physiology-gene-expression-and-increased-pain-sensitization-anxiety-and-depression-in-female-mice
#2
Tian Li, Ramanaiah Mamillapalli, Sheng Ding, Hao Chang, Zhong-Wu Liu, Xiao-Bing Gao, Hugh S Taylor
Endometriosis is an estrogen-dependent inflammatory disorder among reproductive-aged women associated with pelvic pain, anxiety, and depression. Pain is characterized by central sensitization, however it is not clear if endometriosis leads to increased pain perception or if women with the disease are more sensitive to pain, increasing the detection of endometriosis. Endometriosis was induced in mice and changes in behavior including pain perception, brain electrophysiology, and gene expression were characterized...
February 7, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29415410/functional-role-of-kv1-1-and-kv1-3-channels-in-the-neoplastic-progression-steps-of-three-cancer-cell-lines-elucidated-by-scorpion-peptides
#3
Dorra Aissaoui, Saoussen Mlayah-Bellalouna, Jed Jebali, Zaineb Abdelkafi-Koubaa, Soumaya Souid, Wassim Moslah, Houcemeddine Othman, José Luis, Mohamed ElAyeb, Naziha Marrakchi, Khadija Essafi-Benkhadir, Najet Srairi-Abid
Voltage-gated potassium (Kv) channels are known to play a pivotal role in the progression of various cancer types and considered as new targets for designing anti-cancer therapy. However, the fact that many Kv channels are expressed in different cell lines makes it difficult to ascribe a functional role for a given Kv channel on a specific aspect of the tumorogenesis. In this work, we showed that although both Kv1.1 and Kv1.3 channels are expressed in U87 (glioblastoma), MDA-MB-231 (breast cancer) and LS174 (colon adenocarcinoma) cells, these respond differently to KAaH1 or KAaH2, two homologous Kv1 blockers from scorpion venom...
February 2, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29377599/core-shell-cellulose-based-microspheres-for-oral-administration-of-ketoprofen-lysinate
#4
Vincenzo Guarino, Tania Caputo, Paola Calcagnile, Rosaria Altobelli, Christian Demitri, Luigi Ambrosio
Herein, we propose the fabrication of a new carrier with core/shell structure-inner core of cellulose acetate (CA) coated by a micrometric layer of chitosan (CS)-fabricated through an integrated process, which combines Electro Dynamic Atomization (EDA) and layer-by-layer (LbL) technique. We demonstrate that CA based microspheres possess a unique capability to relevantly retain the drugs-that is, Ketoprofen Lysinate (KL)-along the gastric tract, while providing a massive release along the intestine. CS shell slightly influences the morphology and water retention under different pH conditions, improving drug encapsulation without compromising drug release kinetics...
January 26, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29372391/genotype-phenotype-correlation-and-frequency-of-distribution-in-a-cohort-of-chinese-charcot-marie-tooth-patients-associated-with-gdap1-mutations
#5
Pukar Singh Pakhrin, Yongzhi Xie, Zhengmao Hu, Xiaobo Li, Lei Liu, Shunxiang Huang, Binghao Wang, Zihan Yang, Jiejun Zhang, Xin Liu, Kun Xia, Beisha Tang, Ruxu Zhang
Mutations in ganglioside-induced differentiation-associated-protein 1 (GDAP1) have been associated with both subtypes of Charcot-Marie-Tooth (CMT) disease, autosomal recessive (CMT4A and AR-CMT2K) and autosomal dominant (AD-CMT2K). Over 80 different mutations have been identified so far. With the use of Sanger sequencing and Next Generation Sequencing (NGS) technologies, we screened a cohort of 306 unrelated Chinese CMT patients and identified 8 variants in the GDAP1 gene in 4 families, 5 of which were novel (R41H, N201Kfs*5, Q38X, V215I and Q38R)...
January 25, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29319910/reversal-of-mecamylamine-induced-effects-in-healthy-subjects-by-nicotine-receptor-agonists-cognitive-and-electro-physiological-responses
#6
Ricardo Alvarez-Jimenez, Ellen P Hart, Samantha Prins, Marieke de Kam, Joop M A van Gerven, Adam F Cohen, Geert Jan Groeneveld
AIM: Establishing a pharmacologic challenge model could yield an important tool to understand the complex role of the nicotinic cholinergic system in cognition and to develop novel compounds acting on the nicotinic acetylcholine receptor. METHODS: This randomized, double-blind, double-dummy, placebo-controlled, four way cross-over study examined the effects of the nicotinic antagonist mecamylamine on a battery of cognitive and neurophysiologic test with co-administration of a placebo, nicotine or galantamine in order to reverse the cognitive impairment caused by mecamylamine...
January 10, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29238243/analysis-of-time-motion-and-heart-rate-in-elite-male-and-female-beach-handball
#7
Basilio Pueo, Jose M Jimenez-Olmedo, Alfonso Penichet-Tomas, Manuel Ortega Becerra, Jose J Espina Agullo
Beach handball is a spectacular new team sport; however, scientific knowledge about the demands in beach handball is very low. Consequently, the aim of this study was to analyze the physical demands of elite beach handball players by means of time-motion analysis with GPS technology and physiological response with Heart Rate (HR). Both male (n = 12) and female (n = 12) players from the Spanish Beach Handball National Team were recruited for this study. The sample consisted in four matches of two 10-min periods each...
December 2017: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/29194437/an-introduction-to-the-psycho-physiological-stress-test-ppst-a-standardized-instrument-for-evaluating-stress-reactions
#8
Elisabeth Neureiter, Loreen Hajfani, Anne Ahnis, Annett Mierke, Matthias Rose, Gerhard Danzer, Burghard F Klapp
Using a standardized instrument to evaluate patients' stress reactions has become more important in daily clinical routines. Different signs or symptoms of stress are often unilaterally explored: the physiological, psychological or social aspects of stress disorders are each viewed on a single dimension. However, all dimensions afflict patients who have persistent health problems due to chronic stress. Therefore, it is important to use a multidimensional approach to acquire data. The 'Psycho-Physiological-Stress-Test' (PPST) was established to achieve a comprehensive understanding of stress and was further developed at the Charité-Universitätsmedizin Berlin in collaboration with the Psychological Department of Freie Universität Berlin...
2017: PloS One
https://www.readbyqxmd.com/read/29164019/quantitative-analysis-of-electro-anatomical-maps-application-to-an-experimental-model-of-left-bundle-branch-block-cardiac-resynchronization-therapy
#9
David Soto Iglesias, Nicolas Duchateau, Constantine Butakoff Kostantyn Butakov, David Andreu, Juan Fernandez-Armenta, Bart Bijnens, Antonio Berruezo, Marta Sitges, Oscar Camara
Electro-anatomical maps (EAMs) are commonly acquired in clinical routine for guiding ablation therapies. They provide voltage and activation time information on a 3-D anatomical mesh representation, making them useful for analyzing the electrical activation patterns in specific pathologies. However, the variability between the different acquisitions and anatomies hampers the comparison between different maps. This paper presents two contributions for the analysis of electrical patterns in EAM data from biventricular surfaces of cardiac chambers...
2017: IEEE Journal of Translational Engineering in Health and Medicine
https://www.readbyqxmd.com/read/29153889/3d-qsar-studies-on-indole-and-7-azoindole-derivatives-as-rock-2-inhibitors-an-integrative-computational-approach
#10
Santhosh Kumar Nagarajan, Sathya Babu, Honglae Sohn, Panneer Devaraju, Thirumurthy Madhavan
Rho Kinases (ROCK) has been found to regulate a wide range of fundamental cell functions such as contraction, motility, proliferation, and apoptosis. Recent experiments have defined new functions of ROCKs in cells, including centrosome positioning and cell-size regulation, which might contribute to various physiological and pathological states. In this study, we have performed pharmacophore modeling and 3D QSAR studies on a series of 36 indoles and 7-azoindoles derivatives as ROCK2 inhibitors to elucidate the structural variations with their inhibitory activities...
October 9, 2017: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/29130647/randomized-controlled-trial-of-electro-stimulation-therapies-to-modulate-retinal-blood-flow-and-visual-function-in-retinitis-pigmentosa
#11
Ava K Bittner, Kenneth Seger, Rachel Salveson, Samantha Kayser, Natalia Morrison, Patricia Vargas, Deborah Mendelsohn, Jorge Han, Hua Bi, Gislin Dagnelie, Alexandra Benavente, Jessica Ramella-Roman
PURPOSE: We examined changes in visual function and ocular and retinal blood flow (RBF) among retinitis pigmentosa (RP) participants in a randomized controlled trial of electro-stimulation therapies. METHODS: Twenty-one RP participants were randomized (1:1:1) to transcorneal electrical stimulation (TES) at 6 weekly half-hour sessions, electro-acupuncture or inactive laser acupuncture (sham control) at 10 half-hour sessions over 2 weeks. Early Treatment of Diabetic Retinopathy Study (ETDRS) visual acuity (VA), quick contrast sensitivity function, Goldmann visual fields, AdaptDx scotopic sensitivity, spectral flow and colour Doppler imaging of the central retinal artery (CRA), and RBF in macular capillaries were measured twice pre-treatment, after 2 TES sessions, within a week and a month after intervention completion...
November 11, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29116279/persistent-drought-monitoring-using-a-microfluidic-printed-electro-mechanical-sensor-of-stomata-in-planta
#12
Volodymyr B Koman, Tedrick T S Lew, Min Hao Wong, Seon-Yeong Kwak, Juan P Giraldo, Michael S Strano
Stomatal function can be used effectively to monitor plant hydraulics, photosensitivity, and gas exchange. Current approaches to measure single stomatal aperture, such as mold casting or fluorometric techniques, do not allow real time or persistent monitoring of the stomatal function over timescales relevant for long term plant physiological processes, including vegetative growth and abiotic stress. Herein, we utilize a nanoparticle-based conducting ink that preserves stomatal function to print a highly stable, electrical conductometric sensor actuated by the stomata pore itself, repeatedly and reversibly for over 1 week...
November 21, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/29076717/bilayered-bmp2-eluting-coatings-on-graphene-foam-by-electrophoretic-deposition-electroresponsive-bmp2-release-and-enhancement-of-osteogenic-differentiation
#13
Qingqing Yao, Jiajia Jing, Qingyan Zeng, T L Lu, Yu Liu, Xiao Zheng, Qiang Chen
Recent development of three-dimensional graphene foam (GF) with conductive and interconnected macroporous structure is attracting particular attention as platforms for tissue engineering. However, widespread application of GF as bone scaffolds is restricted due to its poor mechanical property and inert surface character. To overcome these drawbacks, in this study, a bilayered biopolymer coating was designed and successfully deposited covering the entire surface area of GF skeleton. A poly(lactic-co-glycolic acid) layer was first dip-coated to strengthen the GF substrate, followed by the electrophoretic codeposition of a hybrid layer, consisting of chitosan and BMP2, to functionalize GF with the ability to recruit and induce osteogenic differentiation of hMSC...
November 7, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28960219/a-bioenergetic-mechanism-for-amoeboid-like-cell-motility-profiles-tested-in-a-microfluidic-electrotaxis-assay
#14
Hagit Peretz-Soroka, Reuven Tirosh, Jolly Hipolito, Erwin Huebner, Murray Alexander, Jason Fiege, Francis Lin
The amoeboid-like cell motility is known to be driven by the acidic enzymatic hydrolysis of ATP in the actin-myosin system. However, the electro-mechano-chemical coupling, whereby the free energy of ATP hydrolysis is transformed into the power of electrically polarized cell movement, is poorly understood. Previous experimental studies showed that actin filaments motion, cytoplasmic streaming, and muscle contraction can be reconstituted under actin-activated ATP hydrolysis by soluble non-filamentous myosin fragments...
November 13, 2017: Integrative Biology: Quantitative Biosciences From Nano to Macro
https://www.readbyqxmd.com/read/28957018/effect-of-morphologic-features-of-neurons-on-the-extracellular-electric-potential-a-simulation-study-using-cable-theory-and-electro-quasi-static-equations
#15
R Bestel, R Appali, U van Rienen, C Thielemann
Microelectrode arrays serve as an indispensable tool in electro-physiological research to study the electrical activity of neural cells, enabling measurements of single cell as well as network communication analysis. Recent experimental studies have reported that the neuronal geometry has an influence on electrical signaling and extracellular recordings. However, the corresponding mechanisms are not yet fully understood and require further investigation. Allowing systematic parameter studies, computational modeling provides the opportunity to examine the underlying effects that influence extracellular potentials...
November 2017: Neural Computation
https://www.readbyqxmd.com/read/28932551/electro-physiological-evidence-of-intercostal-nerve-injury-after-thoracotomy-an-experimental-study-in-a-sheep-model
#16
Ruoyu Zhang, Kerstin Schwabe, Marcus Krüger, Axel Haverich, Joachim K Krauss, Mesbah Alam
BACKGROUND: Although intercostal nerve injury is one of the major causes for post-thoracotomy pain, the exact mechanisms are still unclear. We sought to evaluate the electro-physiological changes of intercostal nerve injury after thoracotomy in a sheep model. METHODS: Adult sheep underwent thoracotomy in the sixth intercostal space by employing diathermy to superior border of the seventh rib. In two sheep, ribs were then spread using retractor spreading for a distance of 7 cm for 30 minutes...
August 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28926819/use-of-electro-olfactography-to-measure-olfactory-acuity-in-the-north-american-bullfrog-lithobates-rana-catesbeiana-tadpole
#17
Jody L Heerema, Caren C Helbing, Greg G Pyle
Olfaction is an important sense for aquatic organisms because it provides information about their surroundings, including nearby food, mates, and predators. Electro-olfactography (EOG) is an electrophysiological technique that measures the response of olfactory tissue to olfactory stimuli, and responses are indicative of olfactory acuity. Previous studies have used this technique on a variety of species including frogs, salamanders, daphniids and, most extensively, fish. In the present study, we introduce a novel modified EOG method for use on Lithobates (Rana) catesbeiana tadpoles...
January 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28904881/numerical-expression-of-volume-status-using-the-bioimpedance-ratio-in-continuous-ambulatory-peritoneal-dialysis-patients-a-pilot-study
#18
Mun Jang, Won Hak Kim, Jung Hee Lee, Mi Soon Kim, Eun Kyoung Lee, So Mi Kim, Jai Won Chang
BACKGROUND: Volume overload results in higher mortality rates in patients on continuous ambulatory peritoneal dialysis (CAPD). The ratio of bioimpedance (RBI) might be a helpful parameter in adjusting dry body weight in CAPD patients. This study examined whether it is possible to distinguish between non-hypervolemic status and hypervolemic status in CAPD patients by using only RBI. METHODS: RBI was calculated as follows: RBI = impedance at 50 kHz/impedance at 500 kHz...
September 2017: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/28898776/effect-of-electro-activated-solutions-of-sodium-acetate-and-sodium-propionate-on-geosmin-producing-streptomyces-avermitilis-strain
#19
Viacheslav Liato, Mohammed Aïder
Electro-activated solutions of salts of weak organic acids are defined as novel potent disinfecting agents that can be used in the agri-food industry. The aim of the present work is to study and understand the destruction mechanism of electro-activated solutions of sodium acetate (EAA) and sodium propionate (EAP) against Streptomyces avermitilis spores. The results of antibacterial activity showed high bacteriostatic effect for all the tested solutions, including sodium hypochlorite used as positive control...
September 6, 2017: Chemosphere
https://www.readbyqxmd.com/read/28880884/two-passive-mechanical-conditions-modulate-power-generation-by-the-outer-hair-cells
#20
Yanju Liu, Sheryl M Gracewski, Jong-Hoon Nam
In the mammalian cochlea, small vibrations of the sensory epithelium are amplified due to active electro-mechanical feedback of the outer hair cells. The level of amplification is greater in the base than in the apex of the cochlea. Theoretical studies have used longitudinally varying active feedback properties to reproduce the location-dependent amplification. The active feedback force has been considered to be proportional to the basilar membrane displacement or velocity. An underlying assumption was that organ of Corti mechanics are governed by rigid body kinematics...
September 2017: PLoS Computational Biology
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