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https://www.readbyqxmd.com/read/29908468/first-report-on-the-pharmacokinetic-profile-of-nimbolide-a-novel-anticancer-agent-in-oral-and-intravenous-administrated-rats-by-lc-ms-method
#1
Shandilya Mahamuni Baira, Amit Khurana, Jaganmohan Somagoni, R Srinivas, Chandraiah Godugu, M V N Kumar Talluri
Nimbolide is a novel, natural compound with promising potential as a drug candidate for anticancer activity. It is isolated from the Indian traditional medicinal plant Azadirachta indica popularly known as neem. The present study was undertaken to explore the oral bioavailability and pharmacokinetic characteristics of nimbolide in rats using the LC/QTOF/MS method. A simple protein precipitation method using acetonitrile was employed for extracting nimbolide from rat plasma. The chromatographic separation of nimbolide and the internal standard (regorafenib) was attained on an Aquity BEH C18 column (100 × 2...
June 2, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29907914/asylum-seekers-in-a-time-of-record-forced-global-displacement-the-role-of-physicians
#2
Katherine C McKenzie, Jon Bauer, P Preston Reynolds
In 2016, over 65 million individuals were displaced from their homes due to human rights abuses, and 262,000 people applied for asylum in the USA. Individuals who have experienced persecution are present in many primary and specialty clinics. A medical forensic evaluation can increase the likelihood of a successful asylum case. This paper reviews the legal framework for asylum and the contribution forensic evaluations can make to this vulnerable population. Physicians without asylum expertise can help these patients by recognizing their legal right to residential protection and referring them to lawyers and physicians with expert skills...
June 15, 2018: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29907312/towards-a-sustainable-bio-based-economy-redirecting-primary-metabolism-to-new-products-with-plant-synthetic-biology
#3
Patrick M Shih
Humans have domesticated many plant species as indispensable sources of food, materials, and medicines. The dawning era of synthetic biology represents a means to further refine, redesign, and engineer crops to meet various societal and industrial needs. Current and future endeavors will utilize plants as the foundation of a bio-based economy through the photosynthetic production of carbohydrate feedstocks for the microbial fermentation of biofuels and bioproducts, with the end goal of decreasing our dependence on petrochemicals...
August 2018: Plant Science: An International Journal of Experimental Plant Biology
https://www.readbyqxmd.com/read/29905547/calcium-hydroxylapatite-microspheres-biocompatibility-and-clinical-effects
#4
U Wollina, C Wiegand, U-C Hipler
Soft tissue fillers are used in aesthetic medicine for volumizing and for contouring. Calcium hydroxylapatite (CaHA) is a fully biodegradable biostimulatory filler. The study presents results of in vitro biocompatibility and cytotoxicity investigations performed on CaHA and illustrates its clinical effects. We used a human cell culture model for in vitro studies with HaCaT keratinocytes and human dermal fibroblasts, known to be a sensitive cell type for biocompatibility and cytotoxicity. Cells were exposed to different concentrations of CaHA (Radiesse®)...
May 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29905060/therapeutic-options-to-manage-bleeding-in-a-dentist%C3%A2-s-office
#5
Claudio Rostetter, Tim Finkenstädt, Martin Rücker, Heinz-Theo Lübbers
This manuscript provides an overview of therapeutic options for the problem of bleeding in a dentist’s office. Bleeding after tooth extraction is a very common finding in dental medicine and persistent blood in the mouth is obviously uncomfortable and sometimes terrifying for the patient. Most bleedings can be stopped simply with compression, in some cases a homeostatic therapy is necessary. For local compression, a swab with tranexamic acid is useful. If local compression is not sufficient, sutures are often an option...
June 18, 2018: Swiss Dental Journal
https://www.readbyqxmd.com/read/29904927/mesenchymal-stromal-cells-from-amniotic-fluid-are-less-prone-to-senescence-compared-to-those-obtained-from-bone-marrow-an-in-vitro-study
#6
Nicola Alessio, Caterina Pipino, Domitilla Mandatori, Pamela Di Tomo, Angela Ferone, Marco Marchiso, Mariarosa A B Melone, Gianfranco Peluso, Assunta Pandolfi, Umberto Galderisi
Mesenchymal stromal cells (MSCs) are considered to be an excellent source in regenerative medicine. They contain several cell subtypes, including multipotent stem cells. MSCs are of particular interest as they are currently being tested using cell and gene therapies for a number of human diseases. They represent a rare population in tissues; for this reason, they require, before being transplanted, an in vitro amplification. This process may induce replicative senescence, thus affecting differentiation and proliferative capacities...
June 15, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29904398/apoptosis-and-antimigration-induction-in-human-skin-cancer-cells-by-rhodomyrtone
#7
Malatee Tayeh, Sirinun Nilwarangkoon, Chantra Tanunyutthawongse, Wilawan Mahabusarakum, Ramida Watanapokasin
Rhodomyrtone is a bioactive compound extracted from Rhodomyrtus tomentosa leaves. It has been used as a traditional herb medicine for many years. Rhodomyrtone exhibits antibacterial activity, anti-inflammatory and antioxidant activities. However, the anticancer activity of rhodomyrtone has not been previously reported. The present study investigated the anticancer effect of rhomyrtone on human epidermoid carcinoma A431 cells. The cytotoxic and antiproliferative effects of rhodomyrtone on A431 cells were investigated by an MTT assay...
June 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29903722/epigen-brazil-initiative-resources-a-latin-american-imputation-panel-and-the-scientific-workflow
#8
Wagner C S Magalhães, Nathalia M Araujo, Thiago P Leal, Gilderlanio S Araujo, Paula J S Viriato, Fernanda S Kehdy, Gustavo N Costa, Mauricio L Barreto, Bernardo L Horta, Maria Fernanda Lima-Costa, Alexandre C Pereira, Eduardo Tarazona-Santos, Maíra R Rodrigues
EPIGEN-Brazil is one of the largest Latin American initiatives at the interface of human genomics, public health, and computational biology. Here, we present two resources to address two challenges to the global dissemination of precision medicine and the development of the bioinformatics know-how to support it. To address the underrepresentation of non-European individuals in human genome diversity studies, we present the EPIGEN-5M+1KGP imputation panel-the fusion of the public 1000 Genomes Project (1KGP) Phase 3 imputation panel with haplotypes derived from the EPIGEN-5M data set (a product of the genotyping of 4...
June 14, 2018: Genome Research
https://www.readbyqxmd.com/read/29903618/engineering-a-second-brain-in-a-dish
#9
REVIEW
Maxime M Mahe
The utilization of human pluripotent stem cells holds great promise in elucidating principles of developmental biology and applications in personalized and regenerative medicine. Breakthroughs from the last decade have allowed the scientific community to better understand and successfully manipulate human pluripotent stem cells using distinct differentiation strategies into a variety of target tissues. This manipulation relies solely on our understanding of developmental processes occurring in model organisms...
August 15, 2018: Brain Research
https://www.readbyqxmd.com/read/29902661/a-feasibility-study-of-the-toxic-responses-of-human-induced-pluripotent-stem-cell-derived-hepatocytes-to-phytochemicals
#10
Tomáš Smutný, Riina Harjumäki, Liisa Kanninen, Marjo Yliperttula, Petr Pávek, Yan-Ru Lou
Herbal medicines have been increasingly used in the last three decades. Despite their popularity, safety issues with herbal products need to be addressed. We performed a feasibility study of the toxic responses of human induced pluripotent stem cell-derived hepatocytes (iHep cells) to phytochemicals in comparison with hepatoblasoma-derived HepG2 cells and long-term human hepatocytes (LTHHs). The iHep cells expressed typical hepatocyte markers cytochrome P450 3A4 (CYP3A4), hepatocyte nuclear factor 4α, and albumin despite the expression of immature markers α-fetoprotein and cytokeratin 19...
June 11, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29902436/the-impact-of-dietary-fiber-on-gut-microbiota-in-host-health-and-disease
#11
REVIEW
Kassem Makki, Edward C Deehan, Jens Walter, Fredrik Bäckhed
Food is a primordial need for our survival and well-being. However, diet is not only essential to maintain human growth, reproduction, and health, but it also modulates and supports the symbiotic microbial communities that colonize the digestive tract-the gut microbiota. Type, quality, and origin of our food shape our gut microbes and affect their composition and function, impacting host-microbe interactions. In this review, we will focus on dietary fibers, which interact directly with gut microbes and lead to the production of key metabolites such as short-chain fatty acids, and discuss how dietary fiber impacts gut microbial ecology, host physiology, and health...
June 13, 2018: Cell Host & Microbe
https://www.readbyqxmd.com/read/29902338/prevalence-of-interfering-antibodies-in-dogs-and-cats-evaluated-using-a-species-independent-assay
#12
Daniel Bergman, Anders Larsson, Helene Hansson-Hamlin, Anna Svensson, Bodil Ström Holst
BACKGROUND: Interfering antibodies in human serum and plasma are known to react with mammalian antibodies in immunoassays and cause false-positive test results. Although this phenomenon was recently shown in companion animals, knowledge regarding immunoassay interference in veterinary medicine is very limited. OBJECTIVES: The aims of this study were to set up a species-independent immunoassay procedure to detect interference in serum samples, to screen for interference in a cross-section of canine and feline patient samples from an animal hospital, and to determine if the detected interference could be neutralized using an immunoassay based on nonmammalian reagents...
June 2018: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/29902162/youth-risk-behavior-surveillance-united-states-2017
#13
Laura Kann, Tim McManus, William A Harris, Shari L Shanklin, Katherine H Flint, Barbara Queen, Richard Lowry, David Chyen, Lisa Whittle, Jemekia Thornton, Connie Lim, Denise Bradford, Yoshimi Yamakawa, Michelle Leon, Nancy Brener, Kathleen A Ethier
PROBLEM: Health-risk behaviors contribute to the leading causes of morbidity and mortality among youth and adults in the United States. In addition, significant health disparities exist among demographic subgroups of youth defined by sex, race/ethnicity, and grade in school and between sexual minority and nonsexual minority youth. Population-based data on the most important health-related behaviors at the national, state, and local levels can be used to help monitor the effectiveness of public health interventions designed to protect and promote the health of youth at the national, state, and local levels...
June 15, 2018: MMWR. Surveillance Summaries: Morbidity and Mortality Weekly Report. Surveillance Summaries
https://www.readbyqxmd.com/read/29901659/dialogues-on-the-threshold-dialogical-learning-for-humanism-and-justice
#14
Arno K Kumagai, Lisa Richardson, Sarah Khan, Ayelet Kuper
Given the constant pressures of overflowing clinics, hospital wards, and emergency departments; shortened duty hours; and increased accreditation requirements, over-burdened clinician teachers ask, "how does one teach for humanism and justice?" How does one step away-even momentarily-and focus teaching on the individual in front of us, the person who requires our attention and care? This approach must not only involve content (the patient's perspective of illness, social context, and life story) but it also must be tightly linked with the ways in which these lessons in living are learned and taught...
June 12, 2018: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29901627/comparison-of-endoscopic-ultrasound-guided-fine-needle-aspiration-and-biopsy-with-22-gauge-and-25-gauge-needles-for-the-precision-medicine-of-pancreatic-cancer-a-retrospective-study
#15
Naohiko Yoshizawa, Reiko Yamada, Takashi Sakuno, Hiroyuki Inoue, Hiroshi Miura, Toshifumi Takeuchi, Misaki Nakamura, Yasuhiko Hamada, Masaki Katsurahara, Kyosuke Tanaka, Noriyuki Horiki, Yoshiyuki Takei
We compared the sample volume of endoscopic ultrasound-guided fine-needle aspiration and biopsy (EUS-FNAB) specimens obtained by 22-gauge (22G) and 25-gauge (25G) needles, and the accuracy rate.This was a retrospective study in a single tertiary referral center. We investigated 153 patients with pancreatic ductal adenocarcinoma (PDAC) who underwent diagnostic EUS-FNAB before neoadjuvant gemcitabine-based chemoradiotherapy between October 2006 and November 2015. We performed immunohistochemical (IHC) analysis of human equilibrative nucleoside transporter 1 using the remnant cell blocks following pathological PDAC diagnosis...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29901194/anti-angiogenic-activity-of-middle-east-medicinal-plants-of-the-lamiaceae-family
#16
Qasem Abdallah, Ibrahim Al-Deeb, Ammar Bader, Fayez Hamam, Kamel Saleh, Amin Abdulmajid
Angiogenesis plays a crucial role in malignant tumor progression and development. The present study aimed to identify lead plants with selective anti-angiogenic properties. A total of 26 methanolic extracts obtained from 18 plants growing in Saudi Arabia and Jordan that belong to the Lamiaceae family were screened for their cytotoxic and anti-angiogenic activities using MTT and rat aortic ring assays, respectively. Four novel extracts of Thymbra capitata (L.) Cav., Phlomis viscosa Poir, Salvia samuelssonii Rech...
June 12, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29901163/norcantharidin-reverses-cisplatin-resistance-and-inhibits-the-epithelial-mesenchymal-transition-of-human-non%C3%A2-small-lung-cancer-cells-by-regulating-the-yap-pathway
#17
Dan Jin, Yan Wu, Cuijie Shao, Yong Gao, Deqiang Wang, Jiwei Guo
Non‑small cell lung cancer (NSCLC) accounts for >80% of all lung cancer cases, which are the leading cause of cancer‑related mortality worldwide. The clinical efficacy of available therapies for NSCLC is often limited due to the development of resistance to anticancer drugs, particularly to cisplatin (DDP). Norcantharidin (NCTD) is a traditional Chinese medicine used in the treatment of many types of cancer, to which patients do not develop resistance. The aim of the present study was to examine the potential synergistic effects of NCTD and DPP on the viability of the the DDP‑resistant NSCLC cell line, A549/DDP...
June 12, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29901071/curcumin-inhibits-cell-proliferation-and-motility-via-suppression-of-trop2-in-bladder-cancer-cells
#18
Lianhua Zhang, Guoliang Yang, Ruiyun Zhang, Liang Dong, Haige Chen, Juanjie Bo, Wei Xue, Yiran Huang
Bladder cancer (BC) has become a serious health prob-lem and represents the second most commonly diagnosed urological tumor. Curcumin is a principal active natural component of turmeric and has long been used in Asia as a traditional herbal medicine. Curcumin suppresses cell growth in various types of cancer, including BC, by regulating numerous molecular signaling pathways. The human trophoblast cell surface antigen 2 (Trop2) belongs to the tumor-associated calcium signal transducer gene family. Trop2 has been described as a cancer driver and is deregulated in various types of cancer...
May 30, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29900850/-medicine-4-0-the-importance-of-electronics-information-technology-and-microsystems-in-modern-medicine-the-case-of-customized-chemotherapy
#19
Bernhard Wolf, Christian Scholze
A paradigm shift seems to emerge, not only in industrial engineering ("Industry 4.0") but also in medicine: we are on the threshold to "Medicine 4.0". For many years, molecular biology had a leading position in life sciences, but today scientists start realizing that microelectronic systems, due to an increasing miniaturization, are reaching the scale of human cells and consequently can be used for therapeutic approaches. This article shows how microelectronics can play a major role in modern medicine, through the example of customized chemotherapy...
May 2018: Médecine Sciences: M/S
https://www.readbyqxmd.com/read/29900784/review-psychopathologies-in-captive-nonhuman-primates-and-approaches-to-diagnosis-and-treatment
#20
Maya S Kummrow, Martin Brüne
  Despite the growing knowledge and literature on primate medicine, assessment and treatment of behavioral abnormalities in nonhuman primates (NHPs) is an underdeveloped field. There is ample evidence for similarity between humans and great apes, including basic neurologic physiology and emotional processes, and no substantial argument exists against a concept of continuity for abnormal conditions in NHPs that emerge in response to adverse experiences, akin to human psychopathology. NHPs have served as models for human psychopathologies for many decades, but the acquired knowledge has only hesitantly been applied to primates themselves...
June 2018: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
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