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https://www.readbyqxmd.com/read/28538731/a-neural-circuit-architecture-for-angular-integration-in-drosophila
#1
Jonathan Green, Atsuko Adachi, Kunal K Shah, Jonathan D Hirokawa, Pablo S Magani, Gaby Maimon
Many animals keep track of their angular heading over time while navigating through their environment. However, a neural-circuit architecture for computing heading has not been experimentally defined in any species. Here we describe a set of clockwise- and anticlockwise-shifting neurons in the Drosophila central complex whose wiring and physiology provide a means to rotate an angular heading estimate based on the fly's angular velocity. We show that each class of shifting neurons exists in two subtypes, with spatiotemporal activity profiles that suggest different roles for each subtype at the start and end of tethered-walking turns...
May 22, 2017: Nature
https://www.readbyqxmd.com/read/28533544/sex-specific-metabolic-profiles-of-androgens-and-its-main-binding-protein-shbg-in-a-middle-aged-population-without-diabetes
#2
Uwe Piontek, Henri Wallaschofski, Gabi Kastenmüller, Karsten Suhre, Henry Völzke, Kieu Trinh Do, Anna Artati, Matthias Nauck, Jerzy Adamski, Nele Friedrich, Maik Pietzner
The role of androgens in metabolism with respect to sex-specific disease associations is poorly understood. Therefore, we aimed to provide molecular signatures in plasma and urine of androgen action in a sex-specific manner using state-of-the-art metabolomics techniques. Our study population consisted of 430 men and 343 women, aged 20-80 years, who were recruited for the cross-sectional population-based Study of Health in Pomerania (SHIP-TREND), Germany. We used linear regression models to identify associations between testosterone, androstenedione and dehydroepiandrosterone-sulfate (DHEAS) as well as sex hormone-binding globulin and plasma or urine metabolites measured by mass spectrometry...
May 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28508994/disease-modifying-effects-of-neural-regeneration-peptide-2945-in-the-gaers-model-of-absence-epilepsy
#3
Gabi Dezsi, Frank Sieg, Mark Thomas, Terence J O'Brien, Marieke van der Hart, Nigel C Jones
Epilepsy is a common neurological condition characterised by spontaneous recurrent seizures. Current anti-epileptic drugs are only effective and tolerated in ~70% of patients, leaving a substantial proportion of patients untreated. As such, there is a pressing need to develop new therapies. We assessed the anti-seizure activity of Neural Regeneration Peptide 2945 (NRP 2945) in the GAERS model of absence epilepsy. Drug effects on seizures were assessed using two study designs. Male adult GAERS were implanted with EEG electrodes to measure seizure frequency...
May 16, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28508954/-perceived-risks-of-food-contaminants
#4
REVIEW
Severine Koch, Mark Lohmann, Astrid Epp, Gaby-Fleur Böl
BACKGROUND: Food contaminants can pose a serious health threat. In order to carry out adequate risk communication measures, the subjective risk perception of the public must be taken into account. In this context, the breadth of the topic and insufficient terminological delimitations from residues and food additives make an elaborate explanation of the topic to consumers indispensable. A representative population survey used language adequate for lay people and a clear definition of contaminants to measure risk perceptions with regard to food contaminants among the general public...
May 16, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/28495371/detecting-joint-pausiness-in-parallel-spike-trains
#5
Matthias Gärtner, Sevil Duvarci, Jochen Roeper, Gaby Schneider
BACKGROUND: Transient periods with reduced neuronal discharge - called 'pauses' - have recently gained increasing attention. In dopamine neurons, pauses are considered important teaching signals, encoding negative reward prediction errors. Particularly simultaneous pauses are likely to have increased impact on information processing. COMPARISON WITH EXISTING METHODS: Available methods for detecting joint pausing analyze temporal overlap of pauses across spike trains...
May 8, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28495109/health-and-health-care-in-israel-an-introduction
#6
REVIEW
A Mark Clarfield, Orly Manor, Gabi Bin Nun, Shifra Shvarts, Zaher S Azzam, Arnon Afek, Fuad Basis, Avi Israeli
Starting well before Independence in 1948, and over the ensuing six decades, Israel has built a robust, relatively efficient public system of health care, resulting in good health statistics throughout the life course. Because of the initiative of people living under the British Mandate for Palestine (1922-48), the development of many of today's health services predated the state's establishment by several decades. An extensive array of high-quality services and technologies is available to all residents, largely free at point of service, via the promulgation of the 1994 National Health Insurance Law...
May 5, 2017: Lancet
https://www.readbyqxmd.com/read/28493706/correction-to-multilayered-modeling-of-particulate-matter-removal-by-a-growing-forest-over-time-from-plant-surface-deposition-to-washoff-via-rainfall
#7
Thomas Schaubroeck, Gaby Deckmyn, Johan Neirynck, Jeroen Staelens, Sandy Adriaenssens, Jo Dewulf, Bart Muys, Kris Verheyen
No abstract text is available yet for this article.
May 11, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28490642/split-arm-swinging-the-effect-of-arm-swinging-manipulation-on-inter-limb-coordination-during-walking
#8
Moshe Bondi, Gabi Zeilig, Ayala Bloch, Alfonso Fasano, Meir Plotnik
Human locomotion is defined by bilateral coordination of gait (BCG) and shared features with the fore-hind limb coordination of quadrupeds. The objective of the present study is to explore the influence of arm swinging (AS) on BCG. Sixteen young healthy individuals (eight females; eight right motor-dominant, eight left-motor dominant) participated. Participants performed 10 walking trials (2 min). In each of the trials AS was unilaterally manipulated (e.g., arm restriction, weight on the wrist) bilaterally manipulated, or not manipulated...
May 10, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28484682/vitamin-c-transporters-in-cancer-current-understanding-and-gaps-in-knowledge
#9
REVIEW
Christina Wohlrab, Elisabeth Phillips, Gabi U Dachs
Sufficient uptake and whole body distribution of vitamin C (ascorbate) is essential for many biochemical processes, including some that are vital for tumor growth and spread. Uptake of ascorbate into cancer cells is modulated by availability, tumor blood flow, tissue diffusion parameters, and ascorbate transport proteins. Uptake into cells is mediated by two families of transport proteins, namely, the solute carrier gene family 23, consisting of sodium-dependent vitamin C transporters (SVCTs) 1 and 2, and the SLC2 family of glucose transporters (GLUTs)...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28479069/automated-pathway-and-reaction-prediction-facilitates-in-silico-identification-of-unknown-metabolites-in-human-cohort-studies
#10
Jan D Quell, Werner Römisch-Margl, Marco Colombo, Jan Krumsiek, Anne M Evans, Robert Mohney, Veikko Salomaa, Ulf de Faire, Leif C Groop, Felix Agakov, Helen C Looker, Paul McKeigue, Helen M Colhoun, Gabi Kastenmüller
Identification of metabolites in non-targeted metabolomics continues to be a bottleneck in metabolomics studies in large human cohorts. Unidentified metabolites frequently emerge in the results of association studies linking metabolite levels to, for example, clinical phenotypes. For further analyses these unknown metabolites must be identified. Current approaches utilize chemical information, such as spectral details and fragmentation characteristics to determine components of unknown metabolites. Here, we propose a systems biology model exploiting the internal correlation structure of metabolite levels in combination with existing biochemical and genetic information to characterize properties of unknown molecules...
April 4, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28471266/preparation-and-characterization-of-safe-microparticles-based-on-xylan
#11
Silvana Cartaxo da Costa Urtiga, Camilla Aquino Azevedo de Lucena Gabi, Giovanna Rodrigues de Araújo Eleamen, Bartolomeu Santos Souza, Hilzeth de Luna Freire Pessôa, Henrique Rodrigues Marcelino, Elisângela Afonso de Moura Mendonça, Eryvaldo Sócrates Tabosa do Egito, Elquio Eleamen Oliveira
This work describes the preparation and evaluation of safe xylan-based microparticles prepared by cross-linking polymerization using sodium trimetaphosphate. The resulting microparticles were evaluated for morphology, particle size, polymer-cross-link agent interaction and in vitro toxicity. The microparticles showed narrow monodisperse size distributions with their mean sizes being between 3.5 µm and 12.5 µm in dried state. FT-IR analyses confirmed the interaction between sodium trimetaphosphate and xylan during the cross-linking process with formation of phosphate ester bonds...
May 4, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28470788/cd36-is-a-marker-of-human-adipocyte-progenitors-with-pronounced-adipogenic-and-triglyceride-accumulation-potential
#12
Hui Gao, Fanny Volat, Lakshmi Sandhow, Jean Galitzky, Thuy Nguyen, David Esteve, Gaby Åström, Niklas Mejhert, Severine Ledoux, Claire Thalamas, Peter Arner, Jean-Claude Guillemot, Hong Qian, Mikael Rydén, Anne Bouloumié
White adipose tissue (WAT) expands in part through adipogenesis, a process involving fat cell generation and fatty acid (FA) storage into triglycerides (TGs). Several findings suggest that inter-individual and regional variations in adipogenesis are linked to metabolic complications. We aimed to identify cellular markers that define human adipocyte progenitors (APs) with pronounced adipogenic/TG storage ability. Using an unbiased single cell screen of passaged human adipose-derived stromal cells (hADSCs) we identified cell clones with similar proliferation rates but discordant capabilities to undergo adipogenic differentiation...
May 4, 2017: Stem Cells
https://www.readbyqxmd.com/read/28457933/circuit-resistance-training-is-an-effective-means-to-enhance-muscle-strength-in-older-adults-a-systematic-review-and-meta-analysis
#13
REVIEW
Assaf Buch, Ofer Kis, Eli Carmeli, Lital Keinan-Boker, Yitshal Berner, Yael Barer, Gabi Shefer, Yonit Marcus, Naftali Stern
Physical exercise, particularly resistance training (RT), is presently the only proven means to reduce the accelerated decline in muscle strength exhibited by older adults, but its effect is hindered by low adherence rate, even under well-structured programs. Here we investigate the efficacy of circuit resistance training (CRT) on muscle strength, lean mass and aerobic capacity in older adults. MEDLINE (Ovid), EMBASE, ClinicalTrials.gov, Cochrane electronic databases were systematically searched including references of pertinent articles up to August 2016...
April 27, 2017: Ageing Research Reviews
https://www.readbyqxmd.com/read/28451025/-asteroid-hyalopathy-benson-s-disease-about-a-case
#14
Yogolelo Asani Bienvenu, Musau Nkola Angel, Kabamba Ngombe Leon, Kapalu Mwangala Socrate, Iye Ombamba Kayimba Bruno, Chenge Borasisi Gaby
We here report a case of a 58 year-old diabetic male patient with asteroid hyalopathy, an affection rarely described in the literature. This study can help focus the attention of scientists on the pathologies of the vitreous disorders in diabetic patients as well as on other systemic diseases asteroid hyalopathy may be associated with.
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28446977/endoscopic-management-of-esophageal-leaks
#15
REVIEW
Gabie K B Ong, Richard K Freeman
Traditionally, gold standard treatment for an acute esophageal perforation has been operative repair. Over the past two decades, there has been a paradigm shift towards the use of esophageal stents. Recent advances in biomaterial allowed a new generation of stents to be manufactured that combined (I) a non-permeable covering; (II) radial force sufficient to occlude a transmural esophageal injury and (III) improved ease of removability. The amalgamation of these developments set the stage for utilizing esophageal stents as part of the management algorithm of an acute esophageal perforation...
March 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28443093/a-novel-cervical-spinal-cord-window-preparation-allows-for-two-photon-imaging-of-t-cell-interactions-with-the-cervical-spinal-cord-microvasculature-during-experimental-autoimmune-encephalomyelitis
#16
Neda Haghayegh Jahromi, Heidi Tardent, Gaby Enzmann, Urban Deutsch, Naoto Kawakami, Stefan Bittner, Dietmar Vestweber, Frauke Zipp, Jens V Stein, Britta Engelhardt
T-cell migration across the blood-brain barrier (BBB) is a crucial step in the pathogenesis of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). Two-photon intravital microscopy (2P-IVM) has been established as a powerful tool to study cell-cell interactions in inflammatory EAE lesions in living animals. In EAE, central nervous system inflammation is strongly pronounced in the spinal cord, an organ in which 2P-IVM imaging is technically very challenging and has been limited to the lumbar spinal cord...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28439571/four-year-cross-sectional-study-of-bleeding-risk-in-dental-patients-on-direct-oral-anticoagulants
#17
Itai Zeevi, Dror M Allon, Eli Rosenfeld, Gal Avishai, Leon Gilman, Joseph Nissan, Gabi Chaushu
OBJECTIVE: New oral anticoagulants, or "direct oral anticoagulants" (DOACs), have been used worldwide in recent years. An evidence-based enigma regarding dental patients using DOACs still exists. METHOD AND MATERIALS: This was a 4-year, cross-sectional study on individuals receiving DOAC therapy, treated in a single maxillofacial center. A bleeding event was the outcome parameter. Potential contributing risk factors were evaluated. RESULTS: Of a total of 111 patients, 72 underwent a total of 305 oral procedures in 115 sessions...
April 24, 2017: Quintessence International
https://www.readbyqxmd.com/read/28429980/maimonides-middle-path-in-the-use-of-health-care
#18
Moriah Ellen, Gabi Bin Nun, Ruth Shach
No abstract text is available yet for this article.
January 1, 2017: Journal of Health Services Research & Policy
https://www.readbyqxmd.com/read/28425398/prospective-indian-study-of-dili-with-confirmed-causality-using-the-roussel-uclaf-causality-assessment-method-rucam-a-report-of-excellence
#19
Rolf Teschke, Gaby Danan
No abstract text is available yet for this article.
May 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28423804/facilitators-and-barriers-of-electronic-health-record-patient-portal-adoption-by-older-adults-a-literature-study
#20
Gaby Anne Wildenbos, Linda Peute, Monique Jaspers
Patient portal usage by older adults, patients aged 50 years old and above, is intended to improve their access and quality of care. Acceptance of patient portals by this target group is low. This paper discusses the results of a literature review to determine the facilitators and barriers that drive or inhibit older patients to adopt patient portals. Articles were included when they described an acceptance, adoption or usability evaluation study of a patient portal. From a total of 245 potentially relevant articles, 8 articles were finally included...
2017: Studies in Health Technology and Informatics
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