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https://www.readbyqxmd.com/read/28235865/deficiency-in-il-1-receptor-type-2-aggravates-k-bxn-serum-transfer-induced-arthritis-in-mice-but-has-no-impact-on-systemic-inflammatory-responses
#1
Praxedis Martin, Gaby Palmer, Emiliana Rodriguez, Christian Alexander Seemayer, Jennifer Palomo, Dominique Talabot-Ayer, Cem Gabay
The biological activity of IL-1 is tightly regulated by the specific receptor antagonist (IL-1Ra) and the decoy receptor IL-1 receptor type 2 (IL-1R2). The role of IL-1Ra has been well demonstrated in IL-1Ra-deficient mice. In contrast, the role of endogenous IL-1R2 remains widely unknown. To define the functional role of endogenous IL-1R2 in the K/BxN serum transfer arthritis model and in IL-1β- or LPS-induced systemic inflammation in vivo, IL-1R2(-/-) mice were created and compared with wild type mice. IL-1R2(-/-) mice bred habitually and exhibited a normal phenotype...
February 24, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28217720/a-graph-partitioning-approach-to-simultaneous-angular-reconstitution
#2
Gabi Pragier, Ido Greenberg, Xiuyuan Cheng, Yoel Shkolnisky
One of the primary challenges in single particle reconstruction with cryo-electron microscopy is to find a three-dimensional model of a molecule using its noisy two-dimensional projection-images. As the imaging orientations of the projection-images are unknown, we suggest a common-lines-based method to simultaneously estimate the imaging orientations of all images that is independent of the distribution of the orientations. Since the relative orientation of each pair of images may only be estimated up to a two-way handedness ambiguity, we suggest an efficient procedure to consistently assign the same handedness to all relative orientations...
September 2016: IEEE Transactions on Computational Imaging
https://www.readbyqxmd.com/read/28205578/insect-herbivory-choristoneura-fumiferana-tortricidea-underlies-tree-population-structure-picea-glauca-pinaceae
#3
Geneviève J Parent, Isabelle Giguère, Gaby Germanos, Mebarek Lamara, Éric Bauce, John J MacKay
Variation in insect herbivory can lead to population structure in plant hosts as indicated by defence traits. In annual herbaceous, defence traits may vary between geographic areas but evidence of such patterns is lacking for long-lived species. This may result from the variety of selection pressures from herbivores, long distance gene flow, genome properties, and lack of research. We investigated the antagonistic interaction between white spruce (Picea glauca) and spruce budworm (SBW, Choristoneura fumiferana) the most devastating forest insect of eastern North America in common garden experiments...
February 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28202394/platelet-rich-plasma-prp-induces-chondroprotection-via-increasing-autophagy-anti-inflammatory-markers-and-decreasing-apoptosis-in-human-osteoarthritic-cartilage
#4
Mayssam Moussa, Daniel Lajeunesse, George Hilal, Oula El Atat, Gaby Haykal, Rim Serhal, Antonio Chalhoub, Charbel Khalil, Nada Alaaeddine
OBJECTIVES: Autophagy constitutes a defense mechanism to overcome aging and apoptosis in osteoarthritic cartilage. Several cytokines and transcription factors are linked to autophagy and play an important role in the degradative cascade in osteoarthritis (OA). Cell therapy such as platelet rich plasma (PRP) has recently emerged as a promising therapeutic tool for many diseases including OA. However, its mechanism of action on improving cartilage repair remains to be determined. The purpose of this study is to investigate the effect of PRP on osteoarthritic chondrocytes and to elucidate the mechanism by which PRP contributes to cartilage regeneration...
March 1, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28197654/temozolomide-during-radiotherapy-of-glioblastoma-multiforme-daily-administration-improves-survival
#5
Silke Birgit Nachbichler, Gabi Schupp, Hendrik Ballhausen, Maximilian Niyazi, Claus Belka
BACKGROUND: Temozolomide-(TMZ)-based chemoradiotherapy defines the current gold standard for the treatment of newly diagnosed glioblastoma. Data regarding the influence of TMZ dose density during chemoradiotherapy are currently not available. We retrospectively compared outcomes in patients receiving no TMZ, TMZ during radiotherapy on radiotherapy days only, and TMZ constantly 7 days a week. PATIENTS AND METHODS: From 2002-2012, a total of 432 patients with newly diagnosed glioblastoma received radiotherapy in our department: 118 patients had radiotherapy alone, 210 had chemoradiotherapy with TMZ (75 mg/m(2)) daily (7/7), and 104 with TMZ only on radiotherapy days (5/7)...
February 14, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28196100/the-development-and-validation-of-a-real-time-location-system-to-reliably-monitor-everyday-activities-in-natural-contexts
#6
Gaby Judah, Jessie de Witt Huberts, Allan Drassal, Robert Aunger
INTRODUCTION: The accurate measurement of behaviour is vitally important to many disciplines and practitioners of various kinds. While different methods have been used (such as observation, diaries, questionnaire), none are able to accurately monitor behaviour over the long term in the natural context of people's own lives. The aim of this work was therefore to develop and test a reliable system for unobtrusively monitoring various behaviours of multiple individuals within the same household over a period of several months...
2017: PloS One
https://www.readbyqxmd.com/read/28183091/emotional-expression-predicts-treatment-outcome-in-focal-psychodynamic-and-cognitive-behavioural-therapy-for-anorexia-nervosa-findings-from-the-antop-study
#7
Hans-Christoph Friederich, Timo Brockmeyer, Beate Wild, Gaby Resmark, Martina de Zwaan, Andreas Dinkel, Stephan Herpertz, Markus Burgmer, Bernd Löwe, Sefik Tagay, Eva Rothermund, Almut Zeeck, Stephan Zipfel, Wolfgang Herzog
No abstract text is available yet for this article.
2017: Psychotherapy and Psychosomatics
https://www.readbyqxmd.com/read/28178298/the-impact-of-prenatal-exposure-to-parasitic-infections-and-to-anthelminthic-treatment-on-antibody-responses-to-routine-immunisations-given-in-infancy-secondary-analysis-of-a-randomised-controlled-trial
#8
Stephen Nash, Alexander J Mentzer, Swaib A Lule, Dennison Kizito, Gaby Smits, Fiona R M van der Klis, Alison M Elliott
BACKGROUND: Chronic parasitic infections are associated with active immunomodulation which may include by-stander effects on unrelated antigens. It has been suggested that pre-natal exposure to parasitic infections in the mother impacts immunological development in the fetus and hence the offspring's response to vaccines, and that control of parasitic infection among pregnant women will therefore be beneficial. METHODOLOGY/PRINCIPAL FINDINGS: We used new data from the Entebbe Mother and Baby Study, a trial of anthelminthic treatment during pregnancy conducted in Uganda, to further investigate this hypothesis...
February 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28169945/causes-and-consequences-of-treatment-variation-in-moderate-and-severe-traumatic-brain-injury-a-multicenter-study
#9
Maryse C Cnossen, Suzanne Polinder, Teuntje M Andriessen, Joukje van der Naalt, Iain Haitsma, Janneke Horn, Gaby Franschman, Pieter E Vos, Ewout W Steyerberg, Hester Lingsma
OBJECTIVES: Although guidelines have been developed to standardize care in traumatic brain injury, between-center variation in treatment approach has been frequently reported. We examined variation in treatment for traumatic brain injury by assessing factors influencing treatment and the association between treatment and patient outcome. DESIGN: Secondary analysis of prospectively collected data. SETTING: Five level I trauma centers in the Netherlands (2008-2009)...
February 6, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28167076/brain-network-alterations-in-the-inflammatory-soup-animal-model-of-migraine
#10
Lino Becerra, James Bishop, Gabi Barmettler, Vanessa Kainz, Rami Burstein, David Borsook
Advances in our understanding of the human pain experience have shifted much of the focus of pain research from the periphery to the brain. Current hypotheses suggest that the progression of migraine depends on abnormal functioning of neurons in multiple brain regions. Accordingly, we sought to capture functional brain changes induced by the application of an inflammatory cocktail known as inflammatory soup (IS), to the dura mater across multiple brain networks. Specifically, we aimed to determine whether IS alters additional neural networks indirectly related to the primary nociceptive pathways via the spinal cord to the thalamus and cortex...
February 3, 2017: Brain Research
https://www.readbyqxmd.com/read/28157415/high-concomitant-misuse-of-fentanyl-in-subjects-on-opioid-maintenance-treatment
#11
Daniela Krause, Diana Plörer, Gabriele Koller, Gabi Martin, Catja Winter, Roland Adam, Minavere Canolli, Jori Al-Iassin, Rainer Musselmann, Stephan Walcher, Frank Schäfer, Oliver Pogarell
BACKGROUND: Concomitant opioid misuse is an increasing problem in opioid maintenance treatment as it interferes with treatment success. OBJECTIVE: Therefore, the rates of concomitant fentanyl misuse in opioid maintained patients were investigated. METHODS: We conducted a cross-sectional study which consisted in collecting data via urine samples and questionnaires in Germany. Urine samples of patients on opioid maintenance treatment were gathered and fentanyl concentrations were measured from 2008 to 2012...
February 3, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28156198/a-multicenter-record-review-of-in-hospital-adverse-drug-events-requiring-a-higher-level-of-care
#12
Kristel Marquet, Neree Claes, Elke De Troy, Gaby Kox, Martijn Droogmans, Arthur Vleugels
OBJECTIVE: Adverse drug events (ADEs) are a worldwide concern, particularly when leading to a higher level of care. This study defines a higher level of care as an unplanned (re)admission to an intensive care unit or an intervention by a Medical Emergency Team. The objectives are to describe the incidence and preventability of ADEs leading to a higher level of care, to assess the types of drug involved, and to identify the risk factors. METHODS: A three-stage retrospective review was performed in six Belgian hospitals...
February 3, 2017: Acta Clinica Belgica
https://www.readbyqxmd.com/read/28144953/the-rhce-ce-501a-allele-encodes-the-parg-antigen-rh60
#13
Erwin A Scharberg, Gabi Rink, Sabine Roth, Susanne Seyboth, Ekkehard Richter, Birgit S Gathof, Jürgen Burkhart, Peter Bugert
No abstract text is available yet for this article.
January 31, 2017: Transfusion
https://www.readbyqxmd.com/read/28144809/comparison-of-cost-and-operative-outcomes-of-robotic-hysterectomy-compared-to-laparoscopic-hysterectomy-across-different-uterine-weights
#14
Gaby N Moawad, Elias D Abi Khalil, Paul Tyan, Michael K Shu, David Samuel, Richard Amdur, Stacey A Scheib, Cherie Q Marfori
Operative cost and outcomes between robotic and laparoscopic hysterectomy across different uterine weights. Retrospective cohort study including patients undergoing robotic and laparoscopic hysterectomy for benign disease at an Academic university hospital. One hundred and ninety six hysterectomies were identified (101 robotic versus 95 laparoscopic). Demographic and surgical characteristics were statistically equivalent. Robotic group had a higher body mass index (±SD) (32.9 ± 6.5 versus 30.4 ± 7.1, p 0...
January 31, 2017: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/28131326/clostridium-difficile-colitis-a-clinical-review
#15
Gabie K B Ong, Tobi J Reidy, Matthew D Huk, Frederick R Lane
BACKGROUND: Clostridium difficile colitis is an important cause of morbidity and mortality in the surgical patient. In recent years, Clostridium difficile infections have shown marked increases in frequency, severity, and resistance to standard treatment. With urgent operative interventions and novel endoscopic approaches, pseudomembranous colitis is being seen more commonly in surgical practices. DATA SOURCES: In this paper, we will review a number of papers from the literature...
January 3, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28129041/survey-on-plasticizers-currently-found-in-pvc-toys-on-the-swiss-market-banned-phthalates-are-only-a-minor-concern
#16
Gregor McCombie, Sandra Biedermann, Gaby Suter, Maurus Biedermann
Plasticizers in toys are a recurring source of criticism and concern, as consumers feel they may endanger the health of their children. Most of the information available in literature concerns the presence or absence of certain phthalic acid ester plasticizers. Very little information can be found in the public domain with respect to the actually used plasticizers at a given time and place. In this paper, we present the plasticizer composition of 118 samples from 88 polyvinyl chloride toys found on the Swiss market in autumn 2015...
January 27, 2017: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
https://www.readbyqxmd.com/read/28125696/molecular-detection-of-plasmodium-malariae-plasmodium-brasilianum-in-non-human-primates-in-captivity-in-costa-rica
#17
Alicia Fuentes-Ramírez, Mauricio Jiménez-Soto, Ruth Castro, Juan José Romero-Zuñiga, Gaby Dolz
One hundred and fifty-two blood samples of non-human primates of thirteen rescue centers in Costa Rica were analyzed to determine the presence of species of Plasmodium using thick blood smears, semi-nested multiplex polymerase chain reaction (SnM-PCR) for species differentiation, cloning and sequencing for confirmation. Using thick blood smears, two samples were determined to contain the Plasmodium malariae parasite, with SnM-PCR, a total of five (3.3%) samples were positive to P. malariae, cloning and sequencing confirmed both smear samples as P...
2017: PloS One
https://www.readbyqxmd.com/read/28118815/how-does-washing-without-water-perform-compared-to-the-traditional-bed-bath-a-systematic-review
#18
Fabian M V Groven, Sandra M G Zwakhalen, Gaby Odekerken-Schröder, Erik J T Joosten, Jan P H Hamers
BACKGROUND: For immobile patients, a body wash in bed is sometimes the only bathing option. Traditionally, the bed bath is performed with water and soap. However, alternatives are increasingly used in health care. Washing without water is one such alternative that has been claimed to offer several advantages, such as improved hygiene and skin condition. This systematic review aims to provide a comprehensive overview of the evidence on outcomes of the washing without water concept compared to the traditional bed bath...
January 25, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28115796/evaluation-of-rapid-genexpert-mtb-rif-method-using-dna-tissue-specimens-of-vertebral-bones-in-patients-with-suspected-spondylitis-tb
#19
Muhammad Nasrum Massi, Karya Triko Biatko, Irda Handayani, Muhammad Yogi Pratama, Sari Septriani, Gaby Maulida Nurdin, Marina B Ali
PURPOSE: To detect Mycobacterium tuberculosis DNA and rifampicin resistance in vertebral bone tissue specimens from spondylitis TB suspects. METHODS AND RESULTS: The rapid GeneXpert MTB/RIF and MGIT 960 liquid culture methods have been used in the specimens. Results from 70 suspects with spondylitis TB shown that 31.42% identified positive for spondylitis TB using culture method, while 88.57% shown positive results using rapid GeneXpert MTB/RIF method. The validity of GeneXpert MTB/RIF shown sensitivity value of 100%, specificity value of 16...
March 2017: Journal of Orthopaedics
https://www.readbyqxmd.com/read/28107398/integrated-chronology-flora-and-faunas-and-paleoecology-of-the-alajuela-formation-late-miocene-of-panama
#20
Bruce J MacFadden, Douglas S Jones, Nathan A Jud, Jorge W Moreno-Bernal, Gary S Morgan, Roger W Portell, Victor J Perez, Sean M Moran, Aaron R Wood
The late Miocene was an important time to understand the geological, climatic, and biotic evolution of the ancient New World tropics and the context for the Great American Biotic Interchange (GABI). Despite this importance, upper Miocene deposits containing diverse faunas and floras and their associated geological context are rare in Central America. We present an integrated study of the geological and paleontological context and age of a new locality from Lago Alajuela in northern Panama (Caribbean side) containing late Miocene marine and terrestrial fossils (plants, invertebrates, and vertebrates) from the Alajuela Formation...
2017: PloS One
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