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https://www.readbyqxmd.com/read/28078358/major-histocompatibility-complex-haplotyping-and-long-amplicon-allele-discovery-in-cynomolgus-macaques-from-chinese-breeding-facilities
#1
Julie A Karl, Michael E Graham, Roger W Wiseman, Katelyn E Heimbruch, Samantha M Gieger, Gaby G M Doxiadis, Ronald E Bontrop, David H O'Connor
Very little is currently known about the major histocompatibility complex (MHC) region of cynomolgus macaques (Macaca fascicularis; Mafa) from Chinese breeding centers. We performed comprehensive MHC class I haplotype analysis of 100 cynomolgus macaques from two different centers, with animals from different reported original geographic origins (Vietnamese, Cambodian, and Cambodian/Indonesian mixed-origin). Many of the samples were of known relation to each other (sire, dam, and progeny sets), making it possible to characterize lineage-level haplotypes in these animals...
January 11, 2017: Immunogenetics
https://www.readbyqxmd.com/read/28076368/functional-laterality-of-task-evoked-activation-in-sensorimotor-cortex-of-preterm-infants-an-optimized-3-t-fmri-study-employing-a-customized-neonatal-head-coil
#2
Lukas Scheef, Jurek A Nordmeyer-Massner, Adam Pr Smith-Collins, Nicole Müller, Gaby Stegmann-Woessner, Jacob Jankowski, Jürgen Gieseke, Mark Born, Hermann Seitz, Peter Bartmann, Hans H Schild, Klaas P Pruessmann, Axel Heep, Henning Boecker
BACKGROUND: Functional magnetic resonance imaging (fMRI) in neonates has been introduced as a non-invasive method for studying sensorimotor processing in the developing brain. However, previous neonatal studies have delivered conflicting results regarding localization, lateralization, and directionality of blood oxygenation level dependent (BOLD) responses in sensorimotor cortex (SMC). Amongst the confounding factors in interpreting neonatal fMRI studies include the use of standard adult MR-coils providing insufficient signal to noise, and liberal statistical thresholds, compromising clinical interpretation at the single subject level...
2017: PloS One
https://www.readbyqxmd.com/read/28073316/clinical-implications-of-the-anatomical-variation-of-deep-venous-thrombosis
#3
Ayman El-Menyar, Mohammad Asim, Gaby Jabbour, Hassan Al-Thani
Introduction Little is known about the anatomic variation and its implication in patients with lower limb deep venous thrombosis (DVT). We studied the clinical presentation, site of thrombosis and risk factors based on the anatomic distribution of lower limb DVT. Methods A retrospective analysis of clinically suspected DVT cases was conducted between 2008 and 2012. DVT was categorized by the location of the thrombosed segment and limb involved. The DVT anatomic segments were assessed according to left-to-right ratio, predisposing factors and clinical presentations...
January 1, 2017: Phlebology
https://www.readbyqxmd.com/read/28065412/quantitative-predictions-orchestrate-visual-signaling-in-drosophila
#4
Anmo J Kim, Lisa M Fenk, Cheng Lyu, Gaby Maimon
Vision influences behavior, but ongoing behavior also modulates vision in animals ranging from insects to primates. The function and biophysical mechanisms of most such modulations remain unresolved. Here, we combine behavioral genetics, electrophysiology, and high-speed videography to advance a function for behavioral modulations of visual processing in Drosophila. We argue that a set of motion-sensitive visual neurons regulate gaze-stabilizing head movements. We describe how, during flight turns, Drosophila perform a set of head movements that require silencing their gaze-stability reflexes along the primary rotation axis of the turn...
January 12, 2017: Cell
https://www.readbyqxmd.com/read/28059884/people-with-spinal-cord-injury-in-israel
#5
Manuel Zwecker, Julie Wolff, Tamara Shaoul, Gabi Zeilig, Iuly Treger
No abstract text is available yet for this article.
February 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28051113/a-comprehensive-custom-panel-design-for-routine-hereditary-cancer-testing-preserving-control-improving-diagnostics-and-revealing-a-complex-variation-landscape
#6
Elisabeth Castellanos, Bernat Gel, Inma Rosas, Eva Tornero, Sheila Santín, Raquel Pluvinet, Juan Velasco, Lauro Sumoy, Jesús Del Valle, Manuel Perucho, Ignacio Blanco, Matilde Navarro, Joan Brunet, Marta Pineda, Lidia Feliubadaló, Gabi Capellá, Conxi Lázaro, Eduard Serra
We wanted to implement an NGS strategy to globally analyze hereditary cancer with diagnostic quality while retaining the same degree of understanding and control we had in pre-NGS strategies. To do this, we developed the I2HCP panel, a custom bait library covering 122 hereditary cancer genes. We improved bait design, tested different NGS platforms and created a clinically driven custom data analysis pipeline. The I2HCP panel was developed using a training set of hereditary colorectal cancer, hereditary breast and ovarian cancer and neurofibromatosis patients and reached an accuracy, analytical sensitivity and specificity greater than 99%, which was maintained in a validation set...
January 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28038390/a-two-year-retrospective-evaluation-of-perampanel-in-patients-with-highly-drug-resistant-epilepsy-and-cognitive-impairment
#7
Bernd Huber, Gaby Schmid
PURPOSE: The objective of this work was to review systematically the efficacy and tolerability of perampanel (PER) in residential patients of an epilepsy center. METHOD: We adopted an industry-independent noninterventional retrospective evaluation on the basis of the paper and electronic records complemented by personal information on the part of the treating neurologists. All patients (N=26, 15 females, mean age: 30, range 21-55years) started on PER from its introduction to the market in September 2012 until December 15th 2013 were included...
December 27, 2016: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28027975/the-transferability-of-virtual-reality-simulation-based-robotic-suturing-skills-to-a-live-porcine-model-in-novice-surgeons-a-single-blind-randomized-controlled-trial-1
#8
Maria V Vargas, Gaby Moawad, Kathryn Denny, Lindsey Happ, Nana Yaa Misa, Samantha Margulies, Jessica Opoku-Anane, Elias Abi Khalil, Cherie Marfori
OBJECTIVE: To assess whether a robotic simulation curriculum for novice surgeons can improve performance of a suturing task in a live porcine model. DESIGN: Randomized controlled trial: (Canadian Task Force Classification I) SETTING: Academic medical center PATIENTS: 35 medical students without robotic surgical experience INTERVENTIONS: Participants were enrolled in an online session of training modules followed by an in-person orientation. Baseline performance testing on the Mimic Technologies daVinci Surgical Simulator (dVSS) was also performed...
December 24, 2016: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28027969/morphological-and-molecular-characterization-of-the-metacercaria-of-paragonimus-caliensis-as-a-separate-species-from-p-mexicanus-in-costa-rica
#9
Roderico Hernández-Chea, Ana Eugenia Jiménez-Rocha, Ruth Castro, David Blair, Gaby Dolz
The trematode Paragonimus mexicanus is the etiological agent of paragonimiasis, a food-borne zoonotic disease in Latin America. This species, as well as Paragonimus caliensis, have been reported from Costa Rica, but it is not known if the two are synonymous. Two types of Paragonimus metacercariae from freshwater pseudothelphusid crabs from several localities in Costa Rica were recognized by light microscopy. Morphologically, these corresponded to descriptions of P. mexicanus and P. caliensis. Metacercariae of the former species lacked a membrane or cyst and their bodies were yellow in color...
December 24, 2016: Parasitology International
https://www.readbyqxmd.com/read/28025784/multi-scale-detection-of-rate-changes-in-spike-trains-with-weak-dependencies
#10
Michael Messer, Kauê M Costa, Jochen Roeper, Gaby Schneider
The statistical analysis of neuronal spike trains by models of point processes often relies on the assumption of constant process parameters. However, it is a well-known problem that the parameters of empirical spike trains can be highly variable, such as for example the firing rate. In order to test the null hypothesis of a constant rate and to estimate the change points, a Multiple Filter Test (MFT) and a corresponding algorithm (MFA) have been proposed that can be applied under the assumption of independent inter spike intervals (ISIs)...
December 26, 2016: Journal of Computational Neuroscience
https://www.readbyqxmd.com/read/28013277/enhancing-the-gabi-kat-arabidopsis-thaliana-t-dna-insertion-mutant-database-by-incorporating-araport11-annotation
#11
Nils Kleinboelting, Gunnar Huep, Bernd Weisshaar
SimpleSearch provides access to a database containing information about T-DNA insertion lines of the GABI-Kat collection of Arabidopsis thaliana mutants. These mutants are an important tool for reverse genetics, and GABI-Kat is the 2(nd) largest collection of such T-DNA insertion mutants. Insertion sites were deduced from flanking sequence tags (FSTs), and the database contains information about mutant plant lines as well as insertion alleles. Here, we describe improvements within the interface (available at http://www...
December 23, 2016: Plant & Cell Physiology
https://www.readbyqxmd.com/read/28009788/effect-of-load-carriage-on-upper-limb-performance
#12
Amir Hadid, Inbar Katz, Tal Haker, Gabi Zeilig, Ruth Defrin, Yoram Epstein, Amit Gefen
: Carrying heavy backpacks are often associated with shoulder discomfort or pain, loss of sensorimotor functions, and brachial plexus injuries that might hamper performance. Based on previous research, the cause of these symptoms could be tissue deformations of the brachial plexus and the subclavian artery caused by the shoulder straps. PURPOSE: To evaluate the changes in the upper extremity hemodynamic and neural function, and to assess how they are associated with brachial plexus tissue deformation during heavy load carriage...
December 22, 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28005825/the-role-of-conservative-management-in-pneumosinus-dilatans-frontalis-with-minimal-bony-deformity
#13
Ilyes Berania, Sam J Daniel, Gaby Doumit, Ramy Kafrouni, Marie-Claude Quintal
The authors describe the conservative management of 2 rare patients of uncomplicated pneumosinus dilatans of the frontal sinus with minimal bossing of the forehead. Regular nasal hygiene in combination with topical corticosteroids was administered with following complete resolution symptoms.
November 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28005656/skeletal-changes-of-an-osteomyocutaneous-facial-allograft-five-years-following-transplantation
#14
Bahar Bassiri Gharb, Antonio Rampazzo, Gaby Doumit, Steven Bernard, Maria Siemionow, Francis Papay, Risal Djohan
BACKGROUND: More than 30 face transplantations have been performed worldwide, most including part of the facial skeletal framework. In this study, the modifications of the skeletal component of a facial allograft were evaluated. METHODS: Standard head computed tomography (CT) scans, CT angiogram, and bone mineral densitometry were evaluated. Cephalometric analysis was performed. The pre and postoperative CT images were overlapped and the skeletal changes were expressed in a numeric and color-coded scale...
December 21, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28004980/tele-rehabilitation-service-delivery-journey-from-prototype-to-robust-in-home-use
#15
Rachel Kizony, Patrice L Weiss, Sharon Harel, Yoram Feldman, Alexei Obuhov, Gabi Zeilig, Mordechai Shani
PURPOSE: The purpose of this study is to present a retrospective study on clients with Acquired Brain Injury (ABI) enrolled in a tele-motion-rehabilitation service program for two or more months. METHODS: Data from 82 clients (46 males; 74 with ABI), aged 22-85 years, are reported. The Kinect-based CogniMotion System (ReAbility Online, Gertner Institute, Tel Hashomer, Israel) provided services that included 30-min biweekly sessions. Participants were evaluated prior to and 2 months following the commencement of service with clinical assessments that measured movements and function of the weaker upper extremity and cognitive abilities...
December 22, 2016: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28000391/psychosocial-impact-on-families-with-an-infant-with-a-hypoplastic-left-heart-syndrome-during-and-after-the-interstage-monitoring-period-a-prospective-mixed-method-study
#16
Gaby Stoffel, Rebecca Spirig, Brian Stiasny, Vera Bernet, Hitendu Dave, Walter Knirsch
AIMS AND OBJECTIVES: To investigate parents' experiences, coping ability and quality of life while monitoring their sick child with hypoplastic left heart syndrome at home. BACKGROUND: Interstage home monitoring for children with hypoplastic left heart syndrome reduces interstage mortality between Norwood stages I and II. Little is known about the psychosocial impact of interstage home monitoring. DESIGN: Prospective mixed-method study. METHOD: This study assessed the psychosocial impact on parents during IHM...
December 21, 2016: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/27998633/limitations-in-prehospital-communication-between-trauma-helicopter-ambulance-services-and-dispatch-centers
#17
Annelieke Maria Karien Harmsen, Georgios Giannakopoulos, Gaby Franschman, Herman Christiaans, Frank Bloemers
BACKGROUND: Prehospital communication with Emergency Medical Services (EMS) is carried out in hectic situations. Proper communication among all medical personal is required to enhance collaboration, to provide the best care and enable shared situational awareness. OBJECTIVE: The objective of this article was to give insight into current Dutch prehospital emergency care communication among all EMS and evaluate the usage of a new physician staffed helicopter EMS (P-HEMS) cancellation model...
December 17, 2016: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27992569/interleukin-33-and-rank-l-interplay-in-the-alveolar-bone-loss-associated-to-periodontitis
#18
Olivier Lapérine, Alexandra Cloitre, Jocelyne Caillon, Olivier Huck, Isaac Maximiliano Bugueno, Paul Pilet, Sophie Sourice, Elodie Le Tilly, Gaby Palmer, Jean-Luc Davideau, Valérie Geoffroy, Jérôme Guicheux, Sarah Beck-Cormier, Philippe Lesclous
INTRODUCTION: Chronic Periodontitis (CP) is an inflammatory disease of bacterial origin that results in alveolar bone destruction. Porphyromonas gingivalis (Pg), one of the main periopathogens, initiates an inflammatory cascade by host immune cells thereby increasing recruitment and activity of osteoclasts, the bone resorbing cells, through enhanced production of the crucial osteoclastogenic factor, RANK-L. Antibodies directed against some cytokines (IL-1β, IL-6 and TNF-α) failed to exhibit convincing therapeutic effect in CP...
2016: PloS One
https://www.readbyqxmd.com/read/27977853/termination-of-pregnancy-due-to-renal-tract-abnormalities-survey-of-97-fetuses-from-a-single-medical-center
#19
Yaakov Melcer, Gaby Kaplan, Ido Ben-Ami, Hilla Bahat, Amos Neeman, Narine Galoyan, Ron Maymon
OBJECTIVE: To assess the spectrum of fetal renal tract abnormalities as a major finding leading to termination of pregnancy (TOP). METHOD: The study population included all pregnant women with singleton pregnancy that underwent TOP in our institute because of fetal renal tract indications between 1998 and 2015. We specifically excluded TOPs performed due to multiple pregnancies, multi system defects, abnormal karyotype and chromosomal or genetic defect not related to renal tract abnormalities...
December 15, 2016: Prenatal Diagnosis
https://www.readbyqxmd.com/read/27970116/tct-736-accuracy-of-predicted-orthogonal-projection-angles-for-valve-deployment-during-transcatheter-aortic-valve-implantation
#20
Gilbert Tang, Gaby Weissman, Guy Weigold, Andrew Ertel, Smita I Negi, Sang Yeub Lee, Christian Shults, Rebecca Torguson, Petros Okubagzi, Augusto Pichard, Lowell Satler, Itshac Itsik Ben-Dor, Toby Rogers, Sarkis Kiramijyan, Edward Koifman, Ron Waksman
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
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