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https://www.readbyqxmd.com/read/28815850/editorial
#1
EDITORIAL
Gaby Hirsbrunner
No abstract text is available yet for this article.
August 2017: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/28797657/systematic-review-of-transabdominal-cerclage-placed-via-laparoscopy-for-the-prevention-of-preterm-birth
#2
REVIEW
Gaby N Moawad, Paul Tyan, Tracey Bracke, Elias D Abi Khalil, Vicky Vargas, Alexis Gimovsky, Cherie Marfori
Preterm birth is the leading cause of neonatal mortality and morbidity. Multiple interventions have been put in place to minimize this occurrence. Despite current recommendations including medical management, cervical length screening, and transvaginal cerclage a substantial number of women still experience preterm birth. For those patients, experts recommend a transabdominal cerclage. In our systematic review, we compare 26 studies (1116 patients) on transabdominal cerclage placed via laparotomy (TAC-lap) to 15 studies (728 patients) on transabdominal cerclage placed via laparoscopy (TAC-lsc)...
August 7, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28793186/an-engineered-optogenetic-switch-for-spatiotemporal-control-of-gene-expression-cell-differentiation-and-tissue-morphogenesis
#3
Lauren Polstein, Mark Juhas, Gabi Hanna, Nenad Bursac, Charles A Gersbach
The precise spatial and temporal control of gene expression, cell differentiation, and tissue morphogenesis has widespread application in regenerative medicine and the study of tissue development. In this work, we applied optogenetics to control cell differentiation and new tissue formation. Specifically, we engineered an optogenetic "on" switch that provides permanent transgene expression following a transient dose of blue light illumination. To demonstrate its utility in controlling cell differentiation and reprogramming, we incorporated an engineered form of the master myogenic factor MyoD into this system in multipotent cells...
August 9, 2017: ACS Synthetic Biology
https://www.readbyqxmd.com/read/28774597/nintedanib-reduces-radiation-induced-microscopic-lung-fibrosis-but-this-cannot-be-monitored-by-ct-imaging-a-preclinical-study-with-a-high-precision-image-guided-irradiator
#4
Dirk De Ruysscher, Patrick Vincent Granton, Natasja Gaby Lieuwes, Stefan van Hoof, Lutz Wollin, Birgit Weynand, Anne-Marie Dingemans, Frank Verhaegen, Ludwig Dubois
BACKGROUND: Nintedanib has anti-fibrotic and anti-inflammatory activity and is approved for the treatment of idiopathic pulmonary fibrosis. The aim of this study was to noninvasively assess the efficacy of nintedanib in a mouse model of partial lung irradiation to prevent radiation-induced lung damage (RILD). METHODS: 266 C57BL/6 adult male mice were irradiated with a single radiation dose (0, 4, 8, 12, 16 or 20Gy) using parallel-opposed fields targeting the upper right lung using a precision image-guided small animal irradiator sparing heart and spine based on micro-CT images...
July 31, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28762187/the-choroid-plexus-is-a-key-cerebral-invasion-route-for-t-cells-after-stroke
#5
Gemma Llovera, Corinne Benakis, Gaby Enzmann, Ruiyao Cai, Thomas Arzberger, Alireza Ghasemigharagoz, Xiang Mao, Rainer Malik, Ivana Lazarevic, Sabine Liebscher, Ali Ertürk, Lilja Meissner, Denis Vivien, Christof Haffner, Nikolaus Plesnila, Joan Montaner, Britta Engelhardt, Arthur Liesz
Neuroinflammation contributes substantially to stroke pathophysiology. Cerebral invasion of peripheral leukocytes-particularly T cells-has been shown to be a key event promoting inflammatory tissue damage after stroke. While previous research has focused on the vascular invasion of T cells into the ischemic brain, the choroid plexus (ChP) as an alternative cerebral T-cell invasion route after stroke has not been investigated. We here report specific accumulation of T cells in the peri-infarct cortex and detection of T cells as the predominant population in the ipsilateral ChP in mice as well as in human post-stroke autopsy samples...
July 31, 2017: Acta Neuropathologica
https://www.readbyqxmd.com/read/28758372/metabolomic-profiling-of-long-term-weight-change-role-of-oxidative-stress-and-urate-levels-in-weight-gain
#6
Cristina Menni, Marie Migaud, Gabi Kastenmüller, Tess Pallister, Jonas Zierer, Annette Peters, Robert P Mohney, Tim D Spector, Vincenzo Bagnardi, Christian Gieger, Steve C Moore, Ana M Valdes
OBJECTIVE: To investigate the association between long-term weight change and blood metabolites. METHODS: Change in BMI over 8.6 ± 3.79 years was assessed in 3,176 females from the TwinsUK cohort (age range: 18.3-79.6, baseline BMI: 25.11 ± 4.35) measured for 280 metabolites at follow-up. Statistically significant metabolites (adjusting for covariates) were included in a multivariable least absolute shrinkage and selection operator (LASSO) model. Findings were replicated in the Cooperative Health Research in the Region of Augsburg (KORA) study (n = 1,760; age range: 25-70, baseline BMI: 27...
July 31, 2017: Obesity
https://www.readbyqxmd.com/read/28724814/comparison-of-intraocular-pressure-measurements-using-goldmann-tonometer-i-care-pro-tonopen-xl-and-schiotz-tonometer-in-patients-after-descemet-stripping-endothelial-keratoplasty
#7
Oded Ohana, David Varssano, Gabi Shemesh
PURPOSE: Post-Descemet stripping endothelial keratoplasty (DSEK) patients are prone for intraocular pressure (IOP) elevations and glaucoma. Corneal characteristics influence various IOP measuring devices in various ways. The aim of this study was to evaluate the agreement between four different IOP measuring devices: Goldmann applanation tonometer (GAT), I-care pro, Tonopen XL, and Schiotz tonometr in patients who underwent DSEK. METHODS: This was a prospective comparative study using a convenience cohort of post-DSEK patients with compact grafts...
July 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28714093/sexual-care-for-patients-receiving-dialysis-a-cross-sectional-study-identifying-the-role-of-nurses-working-in-the-dialysis-department
#8
Gaby F Van Ek, Adina Gawi, Melianthe P J Nicolai, Esmée M Krouwel, Brenda L Den Oudsten, Marjolein E M Den Ouden, Alexander F Schaapherder, Hein Putter, Rob C M Pelger, Henk W Elzevier
AIMS: To explore the role of nurses in the dialysis department in providing sexual care to patients receiving dialysis. BACKGROUND: Sexual health is not self-evident for patients undergoing dialysis; 70% experience sexual dysfunction. Nevertheless, sexual care is often not provided. DESIGN: A national cross-sectional survey. METHODS: Questionnaires (n=171) were sent to employees of 34 dialysis centres from January - May 2016...
July 16, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28704830/sirtuins-in-skin-and-skin-cancers
#9
Liz Mariely Garcia-Peterson, Melissa Jean Wilking-Busch, Mary Ann Ndiaye, Christine Gaby Azer Philippe, Vijayasaradhi Setaluri, Nihal Ahmad
The sirtuins are a family of proteins that comprise class III of the histone deacetylases. These NAD+-dependent proteins have been found to be intricately involved in a variety of important and skin-relevant cellular functions and processes, including aging, UV damage response, oxidative stress, and wound repair. In addition, recent research is unraveling the role of sirtuins in a variety of skin diseases, including melanoma and nonmelanoma skin cancers. In this review, we provide a discussion on the potential roles and implications of different sirtuins in skin-specific cellular processes, which may have relevance to skin health and skin diseases...
2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/28700540/clinical-and-radiological-presentations-and-management-of-blunt-splenic-trauma-a-single-tertiary-hospital-experience
#10
Gaby Jabbour, Ammar Al-Hassani, Ayman El-Menyar, Husham Abdelrahman, Ruben Peralta, Mohammed Ellabib, Hisham Al-Jogol, Mohammed Asim, Hassan Al-Thani
BACKGROUND Splenic injury is the leading cause of major bleeding after blunt abdominal trauma. We examined the clinical and radiological presentations, management, and outcome of blunt splenic injuries (BSI) in our institution. MATERIAL AND METHODS A retrospective study of BSI patients between 2011 and 2014 was conducted. We analyzed and compared management and outcome of different splenic injury grades in trauma patients. RESULTS A total of 191 BSI patients were identified with a mean (SD) age of 26.9 years (13...
July 12, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28673639/management-and-outcome-of-residual-aortic-regurgitation-after-transcatheter-aortic-valve-implantation
#11
Edward Koifman, Romain Didier, Hector Garcia-Garcia, Gaby Weissman, Andrew W Ertel, Sarkis Kiramijyan, Arie Steinvil, Toby Rogers, Nirav Patel, Sandeep Kumar, Arpi Tavil-Shatelyan, Itsik Ben-Dor, Augusto D Pichard, Rebecca Torguson, Jiaxiang Gai, Lowell F Satler, Ron Waksman
We aimed to evaluate the success rates of balloon valvuloplasty post-dilation (BVPD) and a second-valve deployment in reducing residual aortic regurgitation (AR) after transcatheter aortic valve implantation (TAVI) and its impact on outcome. Residual AR immediately post-TAVI in patients with aortic stenosis is a common condition that adversely affects outcome. Patients who underwent TAVI who had more-than-mild residual AR were managed either with medical therapy, re-intervention with BVPD, or a second valve...
August 15, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28669394/ascending-aortic-dimension-measurements-apples-oranges-and-lemons
#12
EDITORIAL
Steven A Goldstein, Federico M Asch, Gaby Weissman, Arturo Evangelista
No abstract text is available yet for this article.
July 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28667112/molybdenum-based-diazotrophy-in-a-sphagnum-peatland-in-northern-minnesota
#13
Melissa J Warren, Xueju Lin, John C Gaby, Cecilia B Kretz, Max Kolton, Peter L Morton, Jennifer Pett-Ridge, David J Weston, Christopher W Schadt, Joel E Kostka, Jennifer B Glass
Microbial N2 fixation (diazotrophy) represents an important nitrogen source to oligotrophic peatland ecosystems, which are important sinks for atmospheric CO2 and susceptible to changing climate. The objectives of this study were: (i) to determine the active microbial group and type of nitrogenase mediating diazotrophy in a ombrotrophic Sphagnum-dominated peat bog (the S1 peat bog, Marcell Experimental Forest, Minnesota, USA); and (ii) to determine the effect of environmental parameters (light, O2, CO2, CH4) on potential rates of diazotrophy measured by acetylene (C2H2) reduction and (15)N2 incorporation...
June 30, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28666431/immunization-against-gnrf-in-adult-cattle-a-prospective-field-study
#14
Gaby Hirsbrunner, Sarah Rigert, Fredi Janett, Jürg Hüsler, Philipp Schnydrig, Ester Lopez, Sue Amatayakul-Chantler, Adrian Steiner
BACKGROUND: Suppression of cyclic activity in cattle is often desired in alpine farming and for feedlot cattle, not intended for breeding. A cattle specific anti-GnRF vaccine (Bopriva™) is registered for use in heifers and bulls in different countries. In adult cows vaccinated with Bopriva™, the median period until recurrence of class III follicles was 78 days from the day of the 2nd vaccination and reversibility could be proven, as out of 11 experimental cows 10 cows became pregnant at first, and one cow at second insemination...
July 1, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28663552/using-attenuated-total-reflection-fourier-transform-infra-red-atr-ftir-spectroscopy-to-distinguish-between-melanoma-cells-with-a-different-metastatic-potential
#15
Refael Minnes, Mati Nissinmann, Yael Maizels, Gabi Gerlitz, Abraham Katzir, Yosef Raichlin
The vast majority of cancer related deaths are caused by metastatic tumors. Therefore, identifying the metastatic potential of cancer cells is of great importance both for prognosis and for determining the correct treatment. Infrared (IR) spectroscopy of biological cells is an evolving research area, whose main aim is to find the spectral differences between diseased and healthy cells. In the present study, we demonstrate that Attenuated Total Reflection Fourier Transform IR (ATR-FTIR) spectroscopy may be used to determine the metastatic potential of cancer cells...
June 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28658206/corrigendum-mineral-supply-for-sustainable-development-requires-resource-governance
#16
Saleem H Ali, Damien Giurco, Nicholas Arndt, Edmund Nickless, Graham Brown, Alecos Demetriades, Ray Durrheim, Maria Amélia Enriquez, Judith Kinnaird, Anna Littleboy, Lawrence D Meinert, Roland Oberhänsli, Janet Salem, Richard Schodde, Gabi Schneider, Olivier Vidal, Natalia Yakovleva
This corrects the article DOI: 10.1038/nature21359.
July 13, 2017: Nature
https://www.readbyqxmd.com/read/28656116/a-large-rice-body-containing-cyst-mimicking-infection-following-total-hip-arthroplasty-a-case-report
#17
Wael Bayoud, Maroun Rizkallah, Samuel Georges, Tonine Younan, Gaby Haykal
INTRODUCTION: Soft tissue mass following total hip arthroplasty raises several differential diagnoses not limited to infection, hematoma, wear debris, malignancy, and bursitis. Rice body formation in the hip region is an uncommon process denoting a chronic inflammation. We report here the second case of its kind in the medical literature of a wide symptomatic rice-like body cyst complicating a total hip arthroplasty. CASE PRESENTATION: This is the case of an 82-year-old white female, presenting with a warm, red, and inflated groin five years after revision of right total hip arthroplasty...
2017: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/28653481/commentary-on-the-mid3-good-practices-paper
#18
Efthymios Manolis, Jacob Brogren, Susan Cole, Justin L Hay, Anna Nordmark, Kristin E Karlsson, Frederike Lentz, Norbert Benda, Gaby Wangorsch, Gerard Pons, Wei Zhao, Valeria Gigante, Francesca Serone, Joseph F Standing, Aris Dokoumetzidis, Juha Vakkilainen, Michiel van den Heuvel, Victor Mangas Sanjuan, Johannes Taminiau, Essam Kerwash, David Khan, Flora Tshinanu Musuamba, Ine Skottheim Rusten
During the last 10 years the European Medicines Agency (EMA) organized a number of workshops on modeling and simulation, working towards greater integration of modeling and simulation (M&S) in the development and regulatory assessment of medicines. In the 2011 EMA - European Federation of Pharmaceutical Industries and Associations (EFPIA) Workshop on Modelling and Simulation, European regulators agreed to the necessity to build expertise to be able to review M&S data provided by companies in their dossier. This led to the establishment of the EMA Modelling and Simulation Working Group (MSWG)...
July 2017: CPT: Pharmacometrics & Systems Pharmacology
https://www.readbyqxmd.com/read/28651567/benefits-and-harms-of-prostate-cancer-screening-predictions-of-the-oncotyrol-prostate-cancer-outcome-and-policy-model
#19
Nikolai Mühlberger, Kristijan Boskovic, Murray D Krahn, Karen E Bremner, Willi Oberaigner, Helmut Klocker, Wolfgang Horninger, Gaby Sroczynski, Uwe Siebert
BACKGROUND: A recent recalibration of the ONCOTYROL Prostate Cancer Outcome and Policy (PCOP) Model, assuming that latent prostate cancer (PCa) detectable at autopsy might be detectable by screening as well, resulted in considerable worsening of the benefit-harm balance of screening. In this study, we used the recalibrated model to assess the effects of familial risk, quality of life (QoL) preferences, age, and active surveillance. METHODS: Men with average and elevated familial PCa risk were simulated in separate models, differing in familial risk parameters...
June 26, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28649953/clinical-restenosis-and-its-predictors-after-implantation-of-everolimus-eluting-bioresorbable-vascular-scaffolds-results-from-the-gabi-r-registry
#20
Julinda Mehilli, Stephan Achenbach, Jochen Woehrle, Moritz Baquet, Thomas Riemer, Thomas Muenzel, Holger Nef, Christoph Naber, Gert Richardt, Ralf Zahn, Tommaso Gori, Till Neumann, Johannes Kastner, Axel Schmermund, Christian Hamm
AIMS: To assess clinical restenosis and its predictors after implantation bioresorbable vascular scaffolds (BVS) in everyday practice in the large scale German-Austrian ABSORB Registry (GABI-R). METHODS AND RESULTS: Between November 2013 and January 2016, 3264 patients underwent BVS implantion in 93 centers of GABI-R. At 6-month follow-up, 24 patients experienced clinically-indicated target lesion revascularization (cTLR) unrelated to BVS thrombosis (cumulative incidence 0...
June 27, 2017: EuroIntervention
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