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https://www.readbyqxmd.com/read/27893628/watershed-areas-in-face-transplantation
#1
Bahar Bassiri Gharb, Russell S Frautschi, Brianna C Halasa, Gaby D Doumit, Risal S Djohan, Steven L Bernard, Brian R Gastman, Maria Z Siemionow, Francis A Papay, Antonio Rampazzo
BACKGROUND: Maxillary artery has traditionally been considered the main blood supply of the facial skeleton. However, the deep and concealed location makes the harvest of facial allografts based on this artery challenging, giving preference to the facial artery. There is growing evidence that the junction between the hard and soft palate may represent a watershed area in facial artery based allografts. The aim of this study was to review the occurrence of partial allograft necrosis and modify the available craniofacial techniques allowing for a reliable harvest of maxillary artery based facial allografts...
November 21, 2016: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27892410/short-term-no2-exposure-is-associated-with-long-chain-fatty-acids-in-prospective-cohorts-from-augsburg-germany-results-from-an-analysis-of-138-metabolites-and-three-exposures
#2
Cavin K Ward-Caviness, Susanne Breitner, Kathrin Wolf, Josef Cyrys, Gabi Kastenmüller, Rui Wang-Sattler, Alexandra Schneider, Annette Peters
BACKGROUND: Short-term exposure to air pollution is associated with morbidity and mortality. Metabolites are intermediaries in biochemical processes, and associations between air pollution and metabolites can yield unique mechanistic insights. METHODS: We used independent cross-sectional samples with targeted metabolomics (138 metabolites across five metabolite classes) from three cohort studies, each a part of the Cooperative Health Research in the Region of Augsburg (KORA)...
October 2016: International Journal of Epidemiology
https://www.readbyqxmd.com/read/27891135/ros-mediated-inhibition-of-s-nitrosoglutathione-reductase-contributes-to-the-activation-of-anti-oxidative-mechanisms
#3
Izabella Kovacs, Christian Holzmeister, Markus Wirtz, Arie Geerlof, Thomas Fröhlich, Gaby Römling, Gitto T Kuruthukulangarakoola, Eric Linster, Rüdiger Hell, Georg J Arnold, Jörg Durner, Christian Lindermayr
Nitric oxide (NO) has emerged as a signaling molecule in plants being involved in diverse physiological processes like germination, root growth, stomata closing and response to biotic and abiotic stress. S-nitrosoglutathione (GSNO) as a biological NO donor has a very important function in NO signaling since it can transfer its NO moiety to other proteins (trans-nitrosylation). Such trans-nitrosylation reactions are equilibrium reactions and depend on GSNO level. The breakdown of GSNO and thus the level of S-nitrosylated proteins are regulated by GSNO-reductase (GSNOR)...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27887713/magnetic-resonance-imaging-correlation-to-intraoperative-findings%C3%A2-of-deeply-infiltrative-endometriosis
#4
Traci E Ito, Elias D Abi Khalil, Myles Taffel, Gaby N Moawad
OBJECTIVE: To show characteristics of deeply infiltrative endometriosis (DIE) on magnetic resonance imaging (MRI) and how they correlate with intraoperative findings. DESIGN: Overview of still and dynamic MRI images of four different patients with DIE. We then used videos from their surgeries to highlight the appearance of endometriosis corresponding to these images (educational video). SETTING: University hospital. PATIENT(S): Four different patients with DIE were included in this video...
November 22, 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27886242/exploring-the-molecular-basis-of-age-related-disease-comorbidities-using-a-multi-omics-graphical-model
#5
Jonas Zierer, Tess Pallister, Pei-Chien Tsai, Jan Krumsiek, Jordana T Bell, Gordan Lauc, Tim D Spector, Cristina Menni, Gabi Kastenmüller
Although association studies have unveiled numerous correlations of biochemical markers with age and age-related diseases, we still lack an understanding of their mutual dependencies. To find molecular pathways that underlie age-related diseases as well as their comorbidities, we integrated aging markers from four different high-throughput omics datasets, namely epigenomics, transcriptomics, glycomics and metabolomics, with a comprehensive set of disease phenotypes from 510 participants of the TwinsUK cohort...
November 25, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27886076/pathogens-inactivated-by-low-energy-electron-irradiation-maintain-antigenic-properties-and-induce-protective-immune-responses
#6
Jasmin Fertey, Lea Bayer, Thomas Grunwald, Alexandra Pohl, Jana Beckmann, Gaby Gotzmann, Javier Portillo Casado, Jessy Schönfelder, Frank-Holm Rögner, Christiane Wetzel, Martin Thoma, Susanne M Bailer, Ekkehard Hiller, Steffen Rupp, Sebastian Ulbert
Inactivated vaccines are commonly produced by incubating pathogens with chemicals such as formaldehyde or β-propiolactone. This is a time-consuming process, the inactivation efficiency displays high variability and extensive downstream procedures are often required. Moreover, application of chemicals alters the antigenic components of the viruses or bacteria, resulting in reduced antibody specificity and therefore stimulation of a less effective immune response. An alternative method for inactivation of pathogens is ionizing radiation...
November 23, 2016: Viruses
https://www.readbyqxmd.com/read/27885433/discussing-sexuality-with-patients-with-parkinson-s-disease-a-survey-among-dutch-neurologists
#7
Petra J M van Hees, Anton A van der Plas, Gaby F van Ek, Hein Putter, Brenda L Den Oudsten, Marjolein E M den Ouden, Henk W Elzevier
Sexual functioning is often impaired in patients with Parkinson's disease (PD) and may affect quality of life of patients and their spouse. However, little is known about the practice patterns of neurologists with regard to discussing sexuality in this field. The aim of this cross-sectional study was to evaluate to what extent neurologists discuss sexuality with PD patients. A 22-item questionnaire was sent to 139 neurologists specializing in PD. The survey contained questions about their attitudes, knowledge, and practice patterns with respect to sexual dysfunction (SD) in patients with PD...
November 24, 2016: Journal of Neural Transmission
https://www.readbyqxmd.com/read/27863746/biophysical-skin-properties-of-grade-1-pressure-ulcers-and-unaffected-skin-in-spinal-cord-injured-and-able-bodied-persons-in-the-unloaded-sacral-region
#8
Anke Scheel-Sailer, Angela Frotzler, Gabi Mueller, Simon Annaheim, René Michel Rossi, Siegfried Derler
AIM OF THE STUDY: To examine biophysical skin properties in the sacral region in spinal cord injury (SCI) patients suffering from a grade 1 pressure ulcer (PU) defined as non-blanchable erythema (SCI/PU), SCI patients in the post-acute phase (SCI/PA) and able-bodied participants (CON). Also, for SCI/PU patients, both the affected skin and healthy skin close to the PU were examined. STUDY DESIGN: An experimental controlled study with a convenience sample. SETTING: A Swiss acute care and rehabilitation clinic specializing in SCIs...
November 8, 2016: Journal of Tissue Viability
https://www.readbyqxmd.com/read/27862514/patient-room-lighting-influences-on-sleep-appraisal-and-mood-in-hospitalized-people
#9
Marina C Giménez, Leonie M Geerdinck, Mathijs Versteylen, Pieter Leffers, Gaby J B M Meekes, Hannelore Herremans, Boris de Ruyter, Jan Willem Bikker, Petra M J C Kuijpers, Luc J M Schlangen
Irregular 24 h light/dark cycles with night-time light exposure and a low amplitude are disruptive for sleep, mood and circadian rhythms. Nevertheless such lighting conditions are quite common in medical care facilities. A controlled clinical trial among 196 cardiology ward patients (mean age 66.5 ± 13.1 years SD) investigated how a patient room lighting intervention affects sleep, appraisal and mood across hospitalization. Patients were either assigned to a standardly-lit room or to a room with an interventional lighting system offering a dynamic 24 h light/dark cycle with low nocturnal light exposure and 2 h of bright light (1750 lux) during daytime...
November 10, 2016: Journal of Sleep Research
https://www.readbyqxmd.com/read/27855687/diagnostic-accuracy-of-methacholine-challenge-tests-assessing-airway-hyperreactivity-in-asthmatic-patients-a-multifunctional-approach
#10
Richard Kraemer, Hans-Jürgen Smith, Thomas Sigrist, Gabi Giger, Roland Keller, Martin Frey
BACKGROUND: There are few studies comparing diagnostic accuracy of different lung function parameters evaluating dose-response characteristics of methacholine (MCH) challenge tests (MCT) as quantitative outcome of airway hyperreactivity (AHR) in asthmatic patients. The aim of this retrospectively analysis of our database (Clinic Barmelweid, Switzerland) was, to assess diagnostic accuracy of several lung function parameters quantitating AHR by dose-response characteristics. METHODS: Changes in effective specific airway conductance (sGeff) as estimate of the degree of bronchial obstruction were compared with concomitantly measured forced expiratory volume in 1 s (FEV1) and forced expiratory flows at 50% forced vital capacity (FEF50)...
November 17, 2016: Respiratory Research
https://www.readbyqxmd.com/read/27836573/human-mesenchymal-stromal-cells-undergo-apoptosis-and-fragmentation-after-intravenous-application-in-immune-competent-mice
#11
Johannes Leibacher, Katrin Dauber, Sabrina Ehser, Veronika Brixner, Katarina Kollar, Anja Vogel, Gabi Spohn, Richard Schäfer, Erhard Seifried, Reinhard Henschler
BACKGROUND AIMS: The biodistribution of human MSCs after systemic delivery is incompletely understood. We investigated the changes in cell size and cell surface markers of human MSCs after intravenous (IV) injection in immune competent mice. METHODS: Male human MSCs were labeled with fluorescent vital dye PKH67 and tracked after IV administration in C57/BL6 mice. MSCs were tracked in blood and different murine tissues by human SRY gene quantitative polymerase chain reaction (qPCR) analysis, flow cytometry and fluorescence microscopy...
November 8, 2016: Cytotherapy
https://www.readbyqxmd.com/read/27831981/squamous-suture-synostosis-a-review-with-emphasis-on-cranial-morphology-and-involvement-of-other-cranial-sutures
#12
Doug Chieffe, Lena Naffaa, Gaby Doumit
Squamosal suture synostosis has received little attention, potentially due to its rare nature. The authors present here a clinical report of isolated unilateral squamosal suture synostosis and a literature review, which produced 6 articles describing 33 patients of squamosal synostosis.Of the reported patients, 15 were associated with a craniofacial syndrome, 10 were nonsyndromic, and 8 were not specified. The cranial morphology varied greatly and only 1 patient was consistent with the morphology predicted by Virchow law-decreased vertical growth with compensatory ipsilateral longitudinal growth (manifesting as occipital and possibly frontal zygomatic bulging)...
November 9, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27822971/drug-induced-liver-injury-is-chronic-liver-disease-a-risk-factor-and-a-clinical-issue
#13
Rolf Teschke, Gaby Danan
Clinicians and practitioners caring for patients with chronic liver disease are often unsure whether drug therapy is a hazard that increases their patient's risk for drug-induced liver injury (DILI). Areas covered: We searched for reports of drug induced liver injury, both idiosyncratic and intrinsic, in patients with chronic liver disease including non-alcoholic and alcoholic liver disease, and cirrhosis. Reports we analyzed include statin treatment in patients with fatty liver, acetaminophen use in alcoholic fatty liver, antituberculous drugs in patients with tuberculosis and viral hepatitis, antiviral medications in hepatitis and antiretroviral medications in HIV/AIDS...
November 8, 2016: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/27803857/trabeculectomy-with-ex-press-implant-versus-ahmed-glaucoma-valve-implantation-a-comparative-study
#14
Michael Waisbourd, Naomi Fischer, Hadas Shalev, Oriel Spierer, Elad Ben Artsi, Rony Rachmiel, Gabi Shemesh, Shimon Kurtz
AIM: To compare the surgical outcomes of trabeculectomy with Ex-PRESS implant and Ahmed glaucoma valve (AGV) implantation. METHODS: Patients who underwent trabeculectomy with Ex-PRESS implants or AGV implantation separately were included in this retrospective chart review. Main outcome measures were surgical failure and complications. Failure was defined as intraocular pressure (IOP) >21 mm Hg or <5 mm Hg on two consecutive visits after 3mo, reoperation for glaucoma, or loss of light perception...
2016: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/27803837/retrograde-tibiopedal-access-as-a-bail-out-procedure-for-endovascular-intervention-complications
#15
Ahmed Amro, Alaa Gabi, Adee Elhamdani, Naveed Iqbal, Mehiar El-Hamdani
Introduction. Retrograde pedal access has been well described in the literature as a secondary approach for limb salvage in critical limb ischemia (CLI) patients. In this manuscript we are presenting a case where retrograde tibiopedal access has been used as a bail-out procedure for the management of superficial femoral artery (SFA) intervention complications. Procedure/Technique. After development of a perforation while trying to cross the totally occluded mid SFA using the conventional CFA access, we were able to cross the mid SFA lesion after accessing the posterior tibial artery in a retrograde fashion and delivered a self-expanding stent which created a flap that sealed the perforation without the need for covered stent...
2016: Case Reports in Vascular Medicine
https://www.readbyqxmd.com/read/27803753/diagnostic-implications-of-computed-tomography-pulmonary-angiography-in-patients-with-pulmonary-embolism
#16
Ayman El-Menyar, Syed Nabir, Nadeem Ahmed, Mohammad Asim, Gaby Jabbour, Hassan Al-Thani
INTRODUCTION: Pulmonary embolism (PE) is a serious cardiovascular and pulmonary complication worldwide. We aimed to assess the implications of different computed tomography pulmonary angiography (CTPA) parameters in patients with acute PE. METHODS: A retrospective observational study to include patients presented with clinical suspicious of PE who underwent CTPA was conducted. Patients' demographics, clinical presentation, risk factors, laboratory investigations, management, and outcome were analyzed...
October 2016: Annals of Thoracic Medicine
https://www.readbyqxmd.com/read/27803022/transcriptional-dynamics-during-human-adipogenesis-and-its-link-to-adipose-morphology-and-distribution
#17
Anna Ehrlund, Niklas Mejhert, Christel Björk, Robin Andersson, Agné Kulyté, Gaby Åström, Masayoshi Itoh, Hideya Kawaji, Timo Lassmann, Carsten O Daub, Piero Carninci, Alistair Rr Forrest, Yoshihide Hayashizaki, Albin Sandelin, Erik Ingelsson, Fantom Consortium, Mikael Rydén, Jurga Laurencikiene, Peter Arner, Erik Arner
White adipose tissue (WAT) can develop into several phenotypes with different pathophysiological impact on type 2 diabetes. To better understand the adipogenic process, the transcriptional events that occur during in vitro differentiation of human adipocytes were investigated and the findings linked to WAT phenotypes. Single molecule transcriptional profiling provided a detailed map of the expressional changes of genes, enhancers, and long non-coding RNAs, where different types of transcripts share common dynamics during differentiation...
November 1, 2016: Diabetes
https://www.readbyqxmd.com/read/27800507/ascorbate-availability-affects-tumor-implantation-take-rate-and-increases-tumor-rejection-in-gulo-mice
#18
Elizabeth J Campbell, Margreet Cm Vissers, Gabi U Dachs
In solid tumors, HIF1 upregulates the expression of hundreds of genes involved in cell survival, tumor growth, and adaptation to the hypoxic microenvironment. HIF1 stabilization and activity are suppressed by prolyl and asparagine hydroxylases, which require oxygen as a substrate and ascorbate as a cofactor. This has led us to hypothesize that intracellular ascorbate availability could modify the hypoxic HIF1 response and influence tumor growth. In this study, we investigated the effect of variable intracellular ascorbate levels on HIF1 induction in cancer cells in vitro, and on tumor-take rate and growth in the Gulo(-/-) mouse...
2016: Hypoxia
https://www.readbyqxmd.com/read/27793071/self-training-to-improve-ue-function-at-the-chronic-stage-post-stroke-a-pilot-randomized-controlled-trial
#19
Debbie Rand, Harold Weingarden, Ronit Weiss, Anat Yacoby, Shlomit Reif, Rachel Malka, David Andrew Shiller, Gabi Zeilig
BACKGROUND AND PURPOSE: On-going practice and use of the weaker upper extremity (UE) are important for maintaining and improving function in individuals with chronic stroke. The effectiveness of two self-training programs for UE function and daily-use was compared. METHODS: In this pilot, single-blinded clinical trial, individuals with chronic stroke were randomized to video-games or traditional self-training (1-hour/day, 6-times/week, 5 weeks). Assessments were performed pre-intervention (an average of two assessments), post-intervention, and at 4-week follow-up...
October 28, 2016: Disability and Rehabilitation
https://www.readbyqxmd.com/read/27789786/non-invasive-near-infrared-fluorescence-imaging-of-the-neutrophil-response-in-a-mouse-model-of-transient-cerebral-ischaemia
#20
Markus Vaas, Gaby Enzmann, Therese Perinat, Ulrich Siler, Janine Reichenbach, Kai Licha, Anja Kipar, Markus Rudin, Britta Engelhardt, Jan Klohs
Near-infrared fluorescence (NIRF) imaging enables non-invasive monitoring of molecular and cellular processes in live animals. Here we demonstrate the suitability of NIRF imaging to investigate the neutrophil response in the brain after transient middle cerebral artery occlusion (tMCAO). We established procedures for ex vivo fluorescent labelling of neutrophils without affecting their activation status. Adoptive transfer of labelled neutrophils in C57BL/6 mice before surgery resulted in higher fluorescence intensities over the ischaemic hemisphere in tMCAO mice with NIRF imaging when compared with controls, corroborated by ex vivo detection of labelled neutrophils using fluorescence microscopy...
October 27, 2016: Journal of Cerebral Blood Flow and Metabolism
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