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https://www.readbyqxmd.com/read/28614560/network-meta-analysis-in-mental-health-research
#1
Yiftach Roth, Gaby Simon Pell, Abraham Zangen
No abstract text is available yet for this article.
June 14, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28604674/genetic-diagnosis-of-mendelian-disorders-via-rna-sequencing
#2
Laura S Kremer, Daniel M Bader, Christian Mertes, Robert Kopajtich, Garwin Pichler, Arcangela Iuso, Tobias B Haack, Elisabeth Graf, Thomas Schwarzmayr, Caterina Terrile, Eliška Koňaříková, Birgit Repp, Gabi Kastenmüller, Jerzy Adamski, Peter Lichtner, Christoph Leonhardt, Benoit Funalot, Alice Donati, Valeria Tiranti, Anne Lombes, Claude Jardel, Dieter Gläser, Robert W Taylor, Daniele Ghezzi, Johannes A Mayr, Agnes Rötig, Peter Freisinger, Felix Distelmaier, Tim M Strom, Thomas Meitinger, Julien Gagneur, Holger Prokisch
Across a variety of Mendelian disorders, ∼50-75% of patients do not receive a genetic diagnosis by exome sequencing indicating disease-causing variants in non-coding regions. Although genome sequencing in principle reveals all genetic variants, their sizeable number and poorer annotation make prioritization challenging. Here, we demonstrate the power of transcriptome sequencing to molecularly diagnose 10% (5 of 48) of mitochondriopathy patients and identify candidate genes for the remainder. We find a median of one aberrantly expressed gene, five aberrant splicing events and six mono-allelically expressed rare variants in patient-derived fibroblasts and establish disease-causing roles for each kind...
June 12, 2017: Nature Communications
https://www.readbyqxmd.com/read/28602548/impact-of-quadrivalent-human-papillomavirus-vaccine-on-genital-warts-in-an-opportunistic-vaccination-structure
#3
Samuel Lurie, Yossi Mizrachi, Gabi Chodick, Rachel Katz, Eduardo Schejter
OBJECTIVE: Genital warts are the most common sexually transmitted disease and have a detrimental impact on quality of life. Genital warts could be prevented by prophylactic HPV vaccination. The objective was to study real-life benefit of opportunistic HPV vaccination on age and gender specific incidence of genital warts. METHODS: We performed a register-based population cohort study from publicly funded health-care provider in Israel. The incidence of genital warts was assessed during three time frame intervals: 2006-2008 (pre-vaccination effect period) 2009-2012 (early post-vaccination effect period) and 2013-2015 (late post-vaccination effect period), with an average annual number of members of 1,765,481, 1,906,774 and 2,042,678 in the years 2006-2008, 2009-2012 and 2013-2015, respectively...
June 8, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28578072/meal-time-behavior-difficulties-but-not-nutritional-deficiencies-correlate-with-sensory-processing-in-children-with-autism-spectrum-disorder
#4
Yael Shmaya, Sigal Eilat-Adar, Yael Leitner, Shimon Reif, Lidia V Gabis
BACKGROUND: Food aversion and nutritional difficulties are common in children with autism spectrum disorder. AIM: To compare meal time behavior of children with autism to their typically developing siblings and to typical controls and to examine if sensory profiles can predict meal time behavior or nutritional deficiencies in the autism group.
June 1, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/28571514/obstetric-ultrasound-aids-prompt-referral-of-gestational-trophoblastic-disease-in-marginalized-populations-on-the-thailand-myanmar-border
#5
Kathryn McGregor, Aung Myat Min, Noaeni Karunkonkowit, Suporn Keereechareon, Mary Ellen Tyrosvoutis, Nay Win Tun, Marcus J Rijken, Gabie Hoogenboom, Machteld Boel, Kesinee Chotivanich, François Nosten, Rose McGready
BACKGROUND: The use of obstetric ultrasound in the diagnosis of gestational trophoblastic disease (GTD) in high-income settings is well established, leading to prompt management and high survival rates. Evidence from low-income settings suggests ultrasound is essential in identifying complicated pregnancies, but with limited studies reviewing specific conditions including GTD. OBJECTIVE: The aim of this study is to review the role of ultrasound in diagnosis and management of GTD in a marginalized population on the Thailand-Myanmar border...
2017: Global Health Action
https://www.readbyqxmd.com/read/28552418/determining-the-effect-of-external-stressors-on-laparoscopic-skills-and-performance-between-obstetrics-and-gynecology-residents
#6
Gaby N Moawad, Paul Tyan, Dipti Kumar, Jill Krapf, Cherie Marfori, Elias D Abi Khalil, James Robinson
STUDY OBJECTIVE: To evaluate the effect of stress on laparoscopic skills between obstetrics and gynecology residents. DESIGN: Observational prospective cohort study. DESIGN CLASSIFICATION: Prospective cohort. SETTING: Urban teaching university hospital. PARTICIPANTS (PATIENTS): Thirty-one obstetrics and gynecology residents, postgraduate years 1 to 4. INTERVENTION: We assessed 4 basic laparoscopic skills at 2 sessions...
May 25, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28551377/increased-chromatin-plasticity-supports-enhanced-metastatic-potential-of-mouse-melanoma-cells
#7
Yael Maizels, Adi Elbaz, Rosari Hernandez-Vicens, Oshrat Sandrusy, Anna Rosenberg, Gabi Gerlitz
Metastasis formation is strongly dependent on the migration capabilities of tumor cells. Recently it has become apparent that nuclear structure and morphology affect the cellular ability to migrate. Previously we found that migration of melanoma cells is both associated with and dependent on global chromatin condensation. Therefore, we anticipated that tumor progression would be associated with increased chromatin condensation. Interestingly, the opposite has been reported for melanoma. In trying to resolve this contradiction, we show that during growth conditions, tumor progression is associated with global chromatin de-condensation that is beneficial for faster proliferation...
May 25, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28538731/a-neural-circuit-architecture-for-angular-integration-in-drosophila
#8
Jonathan Green, Atsuko Adachi, Kunal K Shah, Jonathan D Hirokawa, Pablo S Magani, Gaby Maimon
Many animals keep track of their angular heading over time while navigating through their environment. However, a neural-circuit architecture for computing heading has not been experimentally defined in any species. Here we describe a set of clockwise- and anticlockwise-shifting neurons in the Drosophila central complex whose wiring and physiology provide a means to rotate an angular heading estimate based on the fly's angular velocity. We show that each class of shifting neurons exists in two subtypes, with spatiotemporal activity profiles that suggest different roles for each subtype at the start and end of tethered-walking turns...
May 22, 2017: Nature
https://www.readbyqxmd.com/read/28533544/sex-specific-metabolic-profiles-of-androgens-and-its-main-binding-protein-shbg-in-a-middle-aged-population-without-diabetes
#9
Uwe Piontek, Henri Wallaschofski, Gabi Kastenmüller, Karsten Suhre, Henry Völzke, Kieu Trinh Do, Anna Artati, Matthias Nauck, Jerzy Adamski, Nele Friedrich, Maik Pietzner
The role of androgens in metabolism with respect to sex-specific disease associations is poorly understood. Therefore, we aimed to provide molecular signatures in plasma and urine of androgen action in a sex-specific manner using state-of-the-art metabolomics techniques. Our study population consisted of 430 men and 343 women, aged 20-80 years, who were recruited for the cross-sectional population-based Study of Health in Pomerania (SHIP-TREND), Germany. We used linear regression models to identify associations between testosterone, androstenedione and dehydroepiandrosterone-sulfate (DHEAS) as well as sex hormone-binding globulin and plasma or urine metabolites measured by mass spectrometry...
May 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28508994/disease-modifying-effects-of-neural-regeneration-peptide-2945-in-the-gaers-model-of-absence-epilepsy
#10
Gabi Dezsi, Frank Sieg, Mark Thomas, Terence J O'Brien, Marieke van der Hart, Nigel C Jones
Epilepsy is a common neurological condition characterised by spontaneous recurrent seizures. Current anti-epileptic drugs are only effective and tolerated in ~70% of patients, leaving a substantial proportion of patients untreated. As such, there is a pressing need to develop new therapies. We assessed the anti-seizure activity of Neural Regeneration Peptide 2945 (NRP 2945) in the GAERS model of absence epilepsy. Drug effects on seizures were assessed using two study designs. Male adult GAERS were implanted with EEG electrodes to measure seizure frequency...
May 16, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28508954/-perceived-risks-of-food-contaminants
#11
REVIEW
Severine Koch, Mark Lohmann, Astrid Epp, Gaby-Fleur Böl
BACKGROUND: Food contaminants can pose a serious health threat. In order to carry out adequate risk communication measures, the subjective risk perception of the public must be taken into account. In this context, the breadth of the topic and insufficient terminological delimitations from residues and food additives make an elaborate explanation of the topic to consumers indispensable. A representative population survey used language adequate for lay people and a clear definition of contaminants to measure risk perceptions with regard to food contaminants among the general public...
May 16, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/28495371/detecting-joint-pausiness-in-parallel-spike-trains
#12
Matthias Gärtner, Sevil Duvarci, Jochen Roeper, Gaby Schneider
BACKGROUND: Transient periods with reduced neuronal discharge - called 'pauses' - have recently gained increasing attention. In dopamine neurons, pauses are considered important teaching signals, encoding negative reward prediction errors. Particularly simultaneous pauses are likely to have increased impact on information processing. COMPARISON WITH EXISTING METHODS: Available methods for detecting joint pausing analyze temporal overlap of pauses across spike trains...
June 15, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28495109/health-and-health-care-in-israel-an-introduction
#13
REVIEW
A Mark Clarfield, Orly Manor, Gabi Bin Nun, Shifra Shvarts, Zaher S Azzam, Arnon Afek, Fuad Basis, Avi Israeli
Starting well before Independence in 1948, and over the ensuing six decades, Israel has built a robust, relatively efficient public system of health care, resulting in good health statistics throughout the life course. Because of the initiative of people living under the British Mandate for Palestine (1922-48), the development of many of today's health services predated the state's establishment by several decades. An extensive array of high-quality services and technologies is available to all residents, largely free at point of service, via the promulgation of the 1994 National Health Insurance Law...
May 5, 2017: Lancet
https://www.readbyqxmd.com/read/28493706/correction-to-multilayered-modeling-of-particulate-matter-removal-by-a-growing-forest-over-time-from-plant-surface-deposition-to-washoff-via-rainfall
#14
Thomas Schaubroeck, Gaby Deckmyn, Johan Neirynck, Jeroen Staelens, Sandy Adriaenssens, Jo Dewulf, Bart Muys, Kris Verheyen
No abstract text is available yet for this article.
June 6, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28490642/split-arm-swinging-the-effect-of-arm-swinging-manipulation-on-inter-limb-coordination-during-walking
#15
Moshe Bondi, Gabi Zeilig, Ayala Bloch, Alfonso Fasano, Meir Plotnik
Human locomotion is defined by bilateral coordination of gait (BCG) and shared features with the fore-hind limb coordination of quadrupeds. The objective of the present study is to explore the influence of arm swinging (AS) on BCG. Sixteen young healthy individuals (eight females; eight right motor-dominant, eight left-motor dominant) participated. Participants performed 10 walking trials (2 min). In each of the trials AS was unilaterally manipulated (e.g., arm restriction, weight on the wrist) bilaterally manipulated, or not manipulated...
May 10, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28484682/vitamin-c-transporters-in-cancer-current-understanding-and-gaps-in-knowledge
#16
REVIEW
Christina Wohlrab, Elisabeth Phillips, Gabi U Dachs
Sufficient uptake and whole body distribution of vitamin C (ascorbate) is essential for many biochemical processes, including some that are vital for tumor growth and spread. Uptake of ascorbate into cancer cells is modulated by availability, tumor blood flow, tissue diffusion parameters, and ascorbate transport proteins. Uptake into cells is mediated by two families of transport proteins, namely, the solute carrier gene family 23, consisting of sodium-dependent vitamin C transporters (SVCTs) 1 and 2, and the SLC2 family of glucose transporters (GLUTs)...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28479069/automated-pathway-and-reaction-prediction-facilitates-in-silico-identification-of-unknown-metabolites-in-human-cohort-studies
#17
Jan D Quell, Werner Römisch-Margl, Marco Colombo, Jan Krumsiek, Anne M Evans, Robert Mohney, Veikko Salomaa, Ulf de Faire, Leif C Groop, Felix Agakov, Helen C Looker, Paul McKeigue, Helen M Colhoun, Gabi Kastenmüller
Identification of metabolites in non-targeted metabolomics continues to be a bottleneck in metabolomics studies in large human cohorts. Unidentified metabolites frequently emerge in the results of association studies linking metabolite levels to, for example, clinical phenotypes. For further analyses these unknown metabolites must be identified. Current approaches utilize chemical information, such as spectral details and fragmentation characteristics to determine components of unknown metabolites. Here, we propose a systems biology model exploiting the internal correlation structure of metabolite levels in combination with existing biochemical and genetic information to characterize properties of unknown molecules...
April 4, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28471266/preparation-and-characterization-of-safe-microparticles-based-on-xylan
#18
Silvana Cartaxo da Costa Urtiga, Camilla Aquino Azevedo de Lucena Gabi, Giovanna Rodrigues de Araújo Eleamen, Bartolomeu Santos Souza, Hilzeth de Luna Freire Pessôa, Henrique Rodrigues Marcelino, Elisângela Afonso de Moura Mendonça, Eryvaldo Sócrates Tabosa do Egito, Elquio Eleamen Oliveira
This work describes the preparation and evaluation of safe xylan-based microparticles prepared by cross-linking polymerization using sodium trimetaphosphate. The resulting microparticles were evaluated for morphology, particle size, polymer-cross-link agent interaction, and in vitro toxicity. The microparticles showed narrow monodisperse size distributions with their mean sizes being between 3.5 and 12.5 µm in dried state. FT-IR analyzes confirmed the interaction between sodium trimetaphosphate and xylan during the cross-linking process with formation of phosphate ester bonds...
May 19, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28470788/cd36-is-a-marker-of-human-adipocyte-progenitors-with-pronounced-adipogenic-and-triglyceride-accumulation-potential
#19
Hui Gao, Fanny Volat, Lakshmi Sandhow, Jean Galitzky, Thuy Nguyen, David Esteve, Gaby Åström, Niklas Mejhert, Severine Ledoux, Claire Thalamas, Peter Arner, Jean-Claude Guillemot, Hong Qian, Mikael Rydén, Anne Bouloumié
White adipose tissue (WAT) expands in part through adipogenesis, a process involving fat cell generation and fatty acid (FA) storage into triglycerides (TGs). Several findings suggest that inter-individual and regional variations in adipogenesis are linked to metabolic complications. We aimed to identify cellular markers that define human adipocyte progenitors (APs) with pronounced adipogenic/TG storage ability. Using an unbiased single cell screen of passaged human adipose-derived stromal cells (hADSCs), we identified cell clones with similar proliferation rates but discordant capabilities to undergo adipogenic differentiation...
May 4, 2017: Stem Cells
https://www.readbyqxmd.com/read/28457933/circuit-resistance-training-is-an-effective-means-to-enhance-muscle-strength-in-older-and-middle-aged-adults-a-systematic-review-and-meta-analysis
#20
REVIEW
Assaf Buch, Ofer Kis, Eli Carmeli, Lital Keinan-Boker, Yitshal Berner, Yael Barer, Gabi Shefer, Yonit Marcus, Naftali Stern
BACKGROUND: Physical exercise, particularly resistance training (RT), is proven treatment to reduce the accelerated decline in muscle strength exhibited by older adults, but its effect is hindered by low adherence rate, even under well-structured programs. OBJECTIVE AND DATA SOURCES: We investigated the efficacy of circuit resistance training (CRT) on muscle strength, lean mass and aerobic capacity in older adults based on report in MEDLINE, EMBASE, ClinicalTrials...
April 27, 2017: Ageing Research Reviews
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