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https://www.readbyqxmd.com/read/29337081/abolishment-of-spontaneous-flight-turns-in-visually-responsive-drosophila
#1
Bennett Drew Ferris, Jonathan Green, Gaby Maimon
Animals react rapidly to external stimuli, such as an approaching predator, but in other circumstances, they seem to act spontaneously, without any obvious external trigger. How do the neural processes mediating the execution of reflexive and spontaneous actions differ? We studied this question in tethered, flying Drosophila. We found that silencing a large but genetically defined set of non-motor neurons virtually eliminates spontaneous flight turns while preserving the tethered flies' ability to perform two types of visually evoked turns, demonstrating that, at least in flies, these two modes of action are almost completely dissociable...
January 9, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29334687/cognitive-deficits-in-methamphetamine-users-how-strong-is-the-evidence
#2
Lisa Proebstl, Felicia Kamp, Gabi Koller, Michael Soyka
Methamphetamine use has spread in many European countries and the United States. The current review provides a summary and critical analysis of research on cognitive deficits associated with methamphetamine, also known as "crystal meth." The literature search performed for this review led us to the hypothesis that methamphetamine use is associated with persistent changes in brain metabolism that result in various impairments, such as deficits in memory, attention, and concentration. The dopaminergic system in particular seems to be affected...
January 15, 2018: Pharmacopsychiatry
https://www.readbyqxmd.com/read/29325019/deep-molecular-phenotypes-link-complex-disorders-and-physiological-insult-to-cpg-methylation
#3
Shaza B Zaghlool, Dennis O Mook-Kanamori, Sara Kader, Nisha Stephan, Anna Halama, Rudolf Engelke, Hina Sarwath, Eman K Al-Dous, Yasmin A Mohamoud, Werner Roemisch-Margl, Jerzy Adamski, Gabi Kastenmüller, Nele Friedrich, Alessia Visconti, Pei-Chien Tsai, Tim Spector, Jordana Bell, Mario Falchi, Annika Wahl, Melanie Waldenberger, Annette Peters, Christian Gieger, Maija Pezer, Gordan Lauc, Johannes Graumann, Joel A Malek, Karsten Suhre
Epigenetic regulation of cellular function provides a mechanism for rapid organismal adaptation to changes in health, lifestyle, and environment. Associations of cytosine-guanine di-nucleotide (CpG) methylation with clinical endpoints that overlap with metabolic phenotypes suggest a regulatory role for these CpG sites in the body's response to disease or environmental stress. We previously identified 20 CpG sites in an epigenome-wide association study (EWAS) with metabolomics that were also associated in recent EWASs with diabetes-, obesity-, and smoking-related endpoints...
January 8, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29324638/molecular-research-on-drug-induced-liver-injury
#4
EDITORIAL
Rolf Teschke, Gaby Danan
Drugs may cause liver injury in a few susceptible individuals, but the molecular events that lead to this idiosyncratic, largely dose-independent and non-predictable drug-induced liver injury (DILI) are mostly unknown, since animal models to explore the pathogenetic mechanisms of human idiosyncratic DILI are not yet reliable.[...].
January 11, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29305520/soluble-slamf6-receptor-induces-strong-cd8-t-cell-effector-function-and-improves-anti-melanoma-activity-in-vivo
#5
Galit Eisenberg, Roni Engelstein, Anat Geiger, Emma Hajaj, Sharon Merims, Shoshana Frankenburg, Ronny Uzana, Abraham Rutenberg, Arthur Machlenkin, Gabi Frei, Tamar Peretz, Michal Lotem
SLAMF6, a member of the SLAM (signaling lymphocyte activation molecules) family, is a homotypic-binding immune receptor expressed on NK, T, and B lymphocytes. Phosphorylation variance between T-cell subclones prompted us to explore its role in anti-melanoma immunity. Using a 203-amino acid sequence of the human SLAMF6 (seSLAMF6) ectodomain, we found that seSLAMF6 reduced activation-induced cell death and had an anti-apoptotic effect on tumor infiltrating lymphocytes. CD8+ T cells costimulated with seSLAMF6 secreted more interferon gamma and displayed augmented cytolytic activity...
January 5, 2018: Cancer Immunology Research
https://www.readbyqxmd.com/read/29295842/unopposed-il-18-signaling-leads-to-severe-tlr9-induced-macrophage-activation-syndrome-in-mice
#6
Charlotte Girard-Guyonvarc'h, Jennifer Palomo, Praxedis Martin, Emiliana Rodriguez, Sabina Troccaz, Gaby Palmer, Cem Gabay
The term macrophage activation syndrome (MAS) defines a severe, potentially fatal disorder characterized by overwhelming inflammation and multiorgan involvement. Interleukin (IL)-18 is a pro-inflammatory cytokine belonging to the IL-1 family, the activity of which is regulated by its endogenous inhibitor IL-18 binding protein (IL-18BP). Elevated IL-18 levels have been reported in patients with MAS. Herein we show that upon repeated toll-like receptor (TLR)9 stimulation with CpG, IL-18BP-/- mice display severe MAS manifestations, including increased weight loss, splenomegaly, anemia, thrombocytopenia, hyperferritinemia and bone marrow hemophagocytosis as compared to wild-type mice...
January 2, 2018: Blood
https://www.readbyqxmd.com/read/29289236/polyatomic-ions-from-a-high-current-ion-implanter-driven-by-a-liquid-metal-ion-source
#7
W Pilz, P Laufer, M Tajmar, R Böttger, L Bischoff
High current liquid metal ion sources are well known and found their first application as field emission electric propulsion thrusters in space technology. The aim of this work is the adaption of such kind of sources in broad ion beam technology. Surface patterning based on self-organized nano-structures on, e.g., semiconductor materials formed by heavy mono- or polyatomic ion irradiation from liquid metal (alloy) ion sources (LMAISs) is a very promising technique. LMAISs are nearly the only type of sources delivering polyatomic ions from about half of the periodic table elements...
December 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/29238095/increased-psychological-distress-among-individuals-with-spinal-cord-injury-is-associated-with-central-neuropathic-pain-rather-than-the-injury-characteristics
#8
Hila Gruener, Gabi Zeilig, Yocheved Laufer, Nava Blumen, Ruth Defrin
STUDY DESIGN: Cross-sectional study. OBJECTIVES: Central neuropathic pain (CNP) is common after spinal cord injury (SCI). The psychological impact of CNP is not clear. Previous studies reported depression and pain catastrophizing among patients with SCI and CNP; however, the lack of control groups prevented discerning whether these were attributed to CNP or to the SCI itself. The aim was to examine the psychological distress among individuals with SCI with and without CNP and controls to evaluate its impact and possible source...
December 14, 2017: Spinal Cord
https://www.readbyqxmd.com/read/29237195/-interdisciplinary-inpatient-treatment-for-adolescents-and-young-adults-16%C3%A2-%C3%A2-25-years-with-mental-illness-in-adolescent-psychiatry
#9
Anne Karow, Michael Lipp, Eva Schweigert, Mary Sengutta, Gaby Wiltfang, Linus Wittmann, Martin Lambert, Carola Bindt, Jürgen Gallinat, Michael Schulte-Markwort
Objective The investigation of clinical characteristics of patients in adolescence psychiatry relevant for transition medicine. Methodology Sociodemographic and clinical data (SCID I/II, SIPS/SOPS, SPI-A, GAF, CGI) were consecutively taken from the interdisciplinary inpatient treatment centre for adolescents and young adults with mental disorders (N = 229, aged 16 - 25). Results Average age was 19 years (38 % male, 23 % migration background). A high proportion of early mental illnesses and comorbidities (66 %), psychosis risk syndromes (20 %) and suicidality (54 %), treatment discontinuation (33 %) with daily-life, social and family stress factors (52 % positive family history, 34 % trauma) were observed and a persistently high level of support and treatment was needed despite a significant clinical improvement (p < 0...
December 13, 2017: Psychiatrische Praxis
https://www.readbyqxmd.com/read/29235999/life-cycle-assessment-study-on-polishing-units-for-use-of-treated-wastewater-in-agricultural-reuse
#10
Nurdan Büyükkamacı, Gökçe Karaca
A life cycle assessment (LCA) approach was used in the assessment of environmental impacts of some polishing units for reuse of wastewater treatment plant effluents in agricultural irrigation. These alternative polishing units were assessed: (1) microfiltration and ultraviolet (UV) disinfection, (2) cartridge filter and ultrafiltration (UF), and (3) just UV disinfection. Two different energy sources, electric grid mix and natural gas, were considered to assess the environmental impacts of them. Afterwards, the effluent of each case was evaluated against the criteria required for irrigation of sensitive crops corresponding to Turkey regulations...
December 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/29234020/from-discovery-to-translation-characterization-of-c-mannosyltryptophan-and-pseudouridine-as-markers-of-kidney-function
#11
Peggy Sekula, Katja Dettmer, Franziska C Vogl, Wolfram Gronwald, Lisa Ellmann, Robert P Mohney, Kai-Uwe Eckardt, Karsten Suhre, Gabi Kastenmüller, Peter J Oefner, Anna Köttgen
Using a non-targeted metabolomics platform, we recently identified C-mannosyltryptophan and pseudouridine as non-traditional kidney function markers. The aims of this study were to obtain absolute concentrations of both metabolites in blood and urine from individuals with and without CKD to provide reference ranges and to assess their fractional excretions (FE), and to assess the agreement with their non-targeted counterparts. In individuals without/with CKD, mean plasma and urine concentrations for C-mannosyltryptophan were 0...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29231762/haemolytic-anaemia-and-hepatocitolysis-associated-with-hypermagnesaemia-by-repeated-exposures-to-copper-calcium-fungicides
#12
Constantin Bălăeţ, Bogdan Ioan Coculescu, Maria Bălăeţ, Gheorghe Manole, Gabi Valeriu Dincă
For the medical practice, our manuscript acts as a signal, despite only presenting three cases which feature the association between hepatocytolysis, haemolysis and hypermagnesaemia. This clinical-biologic triad was highlighted with the workers who through the nature of their profession were exposing themselves periodically to vapours which contained copper sulphate neutralised with calcium hydroxide, a fungicide used for fruit trees. We are exclusively assessing the haematological perturbation. In this aetiological context, the generating mechanism for haemolysis is very probable biochemical, where hypercupraemia interferes with cellular antioxidant defence mechanisms...
December 2018: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/29230963/unravelling-current-sexual-care-in-chronic-kidney-disease-perspective-of-social-workers
#13
Gaby F van Ek, Dirry Keurhorst, Esmée M Krouwel, Melianthe P J Nicolai, Marjolein E M Den Ouden, Henk W Elzevier, Hein Putter, Rob C M Pelger, Brenda L Den Oudsten
BACKGROUND: Fifty to eighty percent of patients suffering from chronic kidney disease (CKD) experience a form of sexual dysfunction (SD), even after renal transplantation. Despite this, inquiring about SD is often not included in the daily practice of renal care providers. OBJECTIVES: This paper explores the perspectives of renal social workers regarding sexual care for patients and evaluates their practice, attitude towards responsibility and knowledge of SD. DESIGN: A cross-sectional study was conducted using a 41-item online survey...
December 12, 2017: Journal of Renal Care
https://www.readbyqxmd.com/read/29228062/market-access-and-community-size-influence-pastoral-management-of-native-and-exotic-livestock-species-a-case-study-in-communities-of-the-cordillera-real-in-bolivia-s-high-andean-wetlands
#14
Quentin Struelens, Karina Gonzales Pomar, Susi Loza Herrera, Gaby Nina Huanca, Olivier Dangles, François Rebaudo
Grazing areas management is of utmost importance in the Andean region. In the valleys of the Bolivian Cordillera Real near La Paz, pastoralism constitutes the traditional way for people to insure food security and economical sustainability. In these harsh mountains, unique and productive wetlands sustained by glacial water streams are of utmost importance for feeding cattle herds during the dry season. After the colonization by the Spanish, a shift in livestock species has been observed, with the introduction of exotic species such as cows and sheep, resulting in a different impact on pastures compared to native camelid species-llamas and alpacas...
2017: PloS One
https://www.readbyqxmd.com/read/29217098/prolonged-time-lag-to-final-diagnosis-of-fragile-x-syndrome
#15
Lidia V Gabis, Oded Hochberg, Odelia Leon Attia, Yonit Banet-Levi, Dana Topf, Shahar Shefer
OBJECTIVE: To evaluate the diagnostic process in children ultimately diagnosed with fragile X syndrome (FXS), with an emphasis on the time lag between initial presentation and on diagnosis in female vs male children. STUDY DESIGN: Interviews were conducted with 89 families of children with a final diagnosis of FXS and assessment of time intervals between initial presentation and confirmed molecular diagnosis. RESULTS: Screening of 117 patients (25 female patients) from the 89 families revealed that less than 20% of patients obtained a diagnosis within the first year of seeking medical attention...
December 5, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29204464/a-multimodal-dataset-for-authoring-and-editing-multimedia-content-the-mamem-project
#16
Spiros Nikolopoulos, Panagiotis C Petrantonakis, Kostas Georgiadis, Fotis Kalaganis, Georgios Liaros, Ioulietta Lazarou, Katerina Adam, Anastasios Papazoglou-Chalikias, Elisavet Chatzilari, Vangelis P Oikonomou, Chandan Kumar, Raphael Menges, Steffen Staab, Daniel Müller, Korok Sengupta, Sevasti Bostantjopoulou, Zoe Katsarou, Gabi Zeilig, Meir Plotnik, Amihai Gotlieb, Racheli Kizoni, Sofia Fountoukidou, Jaap Ham, Dimitrios Athanasiou, Agnes Mariakaki, Dario Comanducci, Edoardo Sabatini, Walter Nistico, Markus Plank, Ioannis Kompatsiaris
We present a dataset that combines multimodal biosignals and eye tracking information gathered under a human-computer interaction framework. The dataset was developed in the vein of the MAMEM project that aims to endow people with motor disabilities with the ability to edit and author multimedia content through mental commands and gaze activity. The dataset includes EEG, eye-tracking, and physiological (GSR and Heart rate) signals collected from 34 individuals (18 able-bodied and 16 motor-impaired). Data were collected during the interaction with specifically designed interface for web browsing and multimedia content manipulation and during imaginary movement tasks...
December 2017: Data in Brief
https://www.readbyqxmd.com/read/29194434/metabomatching-using-genetic-association-to-identify-metabolites-in-proton-nmr-spectroscopy
#17
Rico Rueedi, Roger Mallol, Johannes Raffler, David Lamparter, Nele Friedrich, Peter Vollenweider, Gérard Waeber, Gabi Kastenmüller, Zoltán Kutalik, Sven Bergmann
A metabolome-wide genome-wide association study (mGWAS) aims to discover the effects of genetic variants on metabolome phenotypes. Most mGWASes use as phenotypes concentrations of limited sets of metabolites that can be identified and quantified from spectral information. In contrast, in an untargeted mGWAS both identification and quantification are forgone and, instead, all measured metabolome features are tested for association with genetic variants. While the untargeted approach does not discard data that may have eluded identification, the interpretation of associated features remains a challenge...
December 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/29194321/variability-in-management-of-blunt-liver-trauma-and-contribution-of-level-of-acs-cot-verification-status-on-mortality
#18
Christopher J Tignanelli, Bellal Joseph, Jill L Jakubus, Gaby A Iskander, Lena M Napolitano, Mark R Hemmila
BACKGROUND: Patients who sustain blunt liver trauma and are treated at an ACS-COT verified level 1 trauma center have an overall lower risk of mortality compared with patients admitted to a level 2 trauma center. However, elements contributing to these differences are unknown. We hypothesize that practice variation exists between trauma centers in management of blunt liver injury. Our objective is to identify practice variations and their effect on clinical outcomes. METHODS: Data from a statewide collaborative quality initiative for trauma was utilized...
December 1, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29190666/movement-to-outpatient-hysterectomy-for-benign-indications-in-the-united-states-2008-2014
#19
Gaby Moawad, Emelline Liu, Chao Song, Alex Z Fu
INTRODUCTION: The past decade has witnessed adoption of conservative gynecologic treatments, including minimally invasive surgery (MIS), alongside steady declines in inpatient hysterectomies. It remains unclear what factors have contributed to trends in outpatient benign hysterectomy (BH), as well as whether these trends exacerbate disparities. MATERIALS AND METHODS: Retrospective cohort of 527,964 women ≥18 years old who underwent BH from 2008 to 2014. BH surgical approaches included: open/abdominal hysterectomy (AH), vaginal hysterectomy (VH), laparoscopic hysterectomy (LH), and robotic-assisted hysterectomy (RH)...
2017: PloS One
https://www.readbyqxmd.com/read/29190407/perceptions-of-nutrition-education-in-the-current-medical-school-curriculum
#20
Robin L Danek, Kathryn L Berlin, Gabi N Waite, Roy W Geib
BACKGROUND AND OBJECTIVES: Although the National Academy of Sciences has recommended a minimum of 25 hours of nutrition education, the majority of medical schools offer very little to no training or education in nutrition to medical students during their tenure in medical school. In order to assess the relevance and efficacy of current levels of nutrition training as viewed by students, residents, and physicians, as well as possible areas for further improvement, the authors conducted a qualitative study exploring students' experiences...
November 2017: Family Medicine
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