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wall motion score index

Alfonso Jurado-Román, Pilar Agudo-Quílez, Belén Rubio-Alonso, Javier Molina, Belén Díaz, Julio García-Tejada, Roberto Martín, Rocío Tello
BACKGROUND: There are few data on the prognostic significance of the wall motion score index compared with left ventricle ejection fraction after an acute myocardial infarction. Our objective was to compare them after the hyperacute phase. METHODS: Transthoracic echocardiograms were performed in 352 consecutive patients with myocardial infarction, after the first 48 hours of admission and before hospital discharge (median 56.3 hours (48.2-83.1)). We evaluated the ability of the wall motion score index and left ventricular ejection fraction to predict the combined endpoint (mortality and rehospitalization for heart failure) as a primary objective and the independent events of the combined endpoint as a secondary objective...
October 13, 2016: European Heart Journal. Acute Cardiovascular Care
Sang-Don Park, Man-Jong Lee, Yong-Soo Baek, Sung-Woo Kwon, Sung-Hee Shin, Seong-Ill Woo, Dae-Hyeok Kim, Jun Kwan, Keum-Soo Park
AIMS: Ticagrelor has shown greater, more rapid and more consistent platelet inhibition than clopidogrel. However, the superiority of ticagrelor for preventing ischaemic damage in STEMI patients has not been proven. The aim of this trial was to assess whether ticagrelor is superior to clopidogrel in preventing microvascular injury in ST-elevation myocardial infarction (STEMI). METHODS AND RESULTS: Patients with STEMI underwent prospective random assignment to receive a loading dose (LD) of clopidogrel 600 mg or ticagrelor 180 mg (1:1 ratio) before primary percutaneous coronary intervention (PCI)...
October 10, 2016: EuroIntervention
Sothinathan Gurunathan, Asrar Ahmed, Jatinder Pabla, Nikos Karogiannis, Alina Hua, Grace Young, Benoy Nalin Shah, Roxy Senior
INTRODUCTION: Although stress echocardiography (SE) is invaluable in younger populations, its prognostic value may be attenuated in the elderly due to shorter life expectancy and the frequent presence of severe comorbidities. This study sought to evaluate the clinical effectiveness of SE in octogenarians, particularly its prognostic value over clinical variables, in predicting hard events. METHODS: A total of 374 consecutive octogenarians who underwent SE for evaluation of coronary artery disease (CAD) were assessed for feasibility, diagnostic accuracy and safety of the test, and followed up for hard outcomes (all-cause mortality, cardiovascular (CV) deaths and non-fatal myocardial infarction (NFMI))...
September 30, 2016: Heart: Official Journal of the British Cardiac Society
Eun-Sun Jin, Chang-Bum Park, Dong-Hee Kim, Hui-Jeong Hwang, Jin-Man Cho, Il Suk Sohn, Chong-Jin Kim
Early risk stratification is crucial for appropriate management using invasive strategies in non-ST elevation myocardial infarction (NSTEMI), and electrocardiography (ECG) has been widely used for risk stratification. However, ECG findings in NSTEMI vary, and there is a need to define the clinical characteristics and outcomes according to ECG.We analyzed the admission ECGs of 345 NSTEMI patients who underwent coronary angiography from 2006 to 2013. Demographics, procedural characteristics, and clinical outcomes were analyzed...
September 2016: Medicine (Baltimore)
Baixue Zhang, Qi Zhang, Wengang Liu, Wenhui Zhu, Jidong Xiao
OBJECTIVE: To analyze the characteristics of left ventricular rotation and twist in patients with silent myocardial ischemia (SMI) by three-dimensional speckle tracking echocardiography (3D-STE), and to explore the diagnostic value of this method for SMI.
 METHODS: According to Gensini score, 66 patients with SMI were divided into 3 subgroups: a mild lesion group (n=16), a moderate lesion group (n=26) and a severe lesion group (n=24). Thirty patients with negative results in selective coronary angiography served as a control group...
July 2016: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
Hesham K Abdelaziz, Wael Elkilany, Said Khalid, Sameh Sabet, Marwan Saad
OBJECTIVE: The aim of this study was to compare the role of intracoronary (IC) verapamil versus sodium nitroprusside (SNP) in the prevention of microvascular obstruction (MVO) during a primary percutaneous coronary intervention (pPCI). BACKGROUND: A head-to-head comparison between verapamil and SNP in the prevention of MVO lacks evidence. PATIENTS AND METHODS: Sixty patients with ST-segment elevation myocardial infarction were randomized to receive IC verapamil (n=30) versus SNP (n=30) during pPCI...
August 23, 2016: Coronary Artery Disease
Dawod Sharif, Wisam Matanis, Amal Sharif-Rasslan, Uri Rosenschein
BACKGROUND: Myocardial stunning is responsible for partially reversible left ventricular (LV) systolic dysfunction after successful primary percutaneous coronary intervention (PPCI) in patients with acute ST-elevation myocardial infarction (STEMI). AIM: To test the hypothesis that early coronary blood flow (CBF) to LV systolic function ratios, as an equivalent to LV stunning index (SI), predict recovery of LV systolic function after PPCI in patients with acute STEMI...
August 20, 2016: Echocardiography
Chong Liu, Jing Li, Min Ren, Zhen-Zhen Wang, Zi-Yao Li, Fei Gao, Jia-Wei Tian
Two-dimensional speckle tracking echocardiography (2D-STE) multilayer analysis of myocardial deformation is a non-invasive method that enables discrimination of transmural differences owing to myocardial ischemia or necrosis. We wished to ascertain if multilayer longitudinal strains at rest are associated with significant (≥70 %) stenosis of the left anterior descending coronary artery (LAD) in patients with suspected non-ST-elevation acute coronary syndrome (NSTE-ACS). Our cohort comprised 113 consecutive patients with suspected NSTE-ACS and preserved ejection fraction (EF)...
August 13, 2016: International Journal of Cardiovascular Imaging
Preman Kumarathurai, Christian Anholm, Olav W Nielsen, Ole P Kristiansen, Jens Mølvig, Sten Madsbad, Steen B Haugaard, Ahmad Sajadieh
BACKGROUND: Patients with type 2 diabetes (T2D) and coronary artery disease (CAD) have increased risk of cardiac dysfunction. The diabetic heart is characterized by increased fatty acid oxidation and reduced glucose uptake resulting in reduced cardiac efficiency. Glucagon-like peptide-1 (GLP-1) has shown to increase myocardial glucose uptake and to improve myocardial function. We examined the effect of the GLP-1 receptor agonist, liraglutide, on the systolic function of the left ventricle (LV) in patients with T2D and stable CAD...
2016: Cardiovascular Diabetology
Gianluca Campo, Giampaolo Morciano, Rita Pavasini, Massimo Bonora, Luigi Sbano, Simone Biscaglia, Matteo Bovolenta, Mirko Pinotti, Silvia Punzetti, Paola Rizzo, Giorgio Aquila, Carlotta Giorgi, Roberto Ferrari, Paolo Pinton
BACKGROUND: Recent studies in cell cultures hypothesized that the long-sought molecular pore of the mitochondrial permeability transition pore could be the Fo ATP synthase C subunit (Csub). We assessed Csub in patients with ST-segment elevation myocardial infarction (STEMI) and if it is associated with surrogate endpoints of myocardial reperfusion. METHODS: We enrolled 158 first-time acute anterior STEMI treated with successful percutaneous coronary intervention (PCI)...
October 15, 2016: International Journal of Cardiology
Craig R Louer, Sean L Boone, Andre K Guthrie, John R Motley, Ryan P Calfee, Lindley B Wall
BACKGROUND: The physical risk factors leading to distal radial fractures are poorly understood. The goal of this study was to compare postural stability between older adults with and without a prior distal radial fragility fracture. METHODS: This case-control evaluation was performed at a single tertiary institution. The fracture cohort comprised 23 patients treated for a low-energy distal radial fracture within 6 to 24 months prior to this study. Twenty-three age and sex-matched control participants, without a prior fragility fracture, were selected from an outpatient clinic population...
July 20, 2016: Journal of Bone and Joint Surgery. American Volume
Hendrik J Boiten, Hande Ekmen, Felix Zijlstra, Ron T van Domburg, Arend F L Schinkel
The role of early coronary revascularization in the management of stable coronary artery disease remains controversial. The aim of this study was to evaluate the impact of early coronary revascularization on long-term outcomes (>10 years) after an ischemic dobutamine stress echocardiography (DSE) in patients with known or suspected coronary artery disease. Patients without stress-induced ischemia on DSE and those who underwent late coronary revascularization (>90 days after DSE) were excluded. The final study cohort consisted of 905 patients...
September 1, 2016: American Journal of Cardiology
Rodolfo Citro, Eduardo Bossone, Guido Parodi, Scipione Carerj, Quirino Ciampi, Gennaro Provenza, Concetta Zito, Costantina Prota, Angelo Silverio, Olga Vriz, Antonello D'Andrea, Gennaro Galasso, Cesare Baldi, Fausto Rigo, Massimo Piepoli, Jorge Salerno-Uriarte, Federico Piscione
AIM: To determine the prevalence, clinical characteristics, in-hospital course and determinants of major adverse events in a cohort of Caucasian patients with Takotsubo syndrome (TTS) and right ventricular involvement (RVi), regardless of left ventricular variant forms. METHODS AND RESULTS: The study population consisted of 424 patients (mean age 69.1±11.5years; female 92.2%) with a diagnosis of TTS divided into two groups according to the presence or absence of RVi...
September 15, 2016: International Journal of Cardiology
Jamal N Khan, Sheraz A Nazir, Anvesha Singh, Abhishek Shetye, Florence Y Lai, Charles Peebles, Joyce Wong, John P Greenwood, Gerry P McCann
BACKGROUND: Late gadolinium-enhanced cardiovascular magnetic resonance imaging overestimates infarct size and underestimates recovery of dysfunctional segments acutely post ST-segment-elevation myocardial infarction. We assessed whether cardiovascular magnetic resonance imaging-derived segmental myocardial strain and markers of myocardial injury could improve the accuracy of late gadolinium-enhancement in predicting functional recovery after ST-segment-elevation myocardial infarction...
June 2016: Circulation. Cardiovascular Imaging
R Du Toit, P G Herbst, A van Rensburg, L M du Plessis, H Reuter, A F Doubell
BACKGROUND: African American ethnicity is independently associated with lupus myocarditis compared with other ethnic groups. In the mixed racial population of the Western Cape, South Africa, no data exists on the clinical features/outcome of lupus myocarditis. OBJECTIVES: The objective of this study was to give a comprehensive description of the clinical features and outcome of acute lupus myocarditis in a mixed racial population. METHODS: Clinical records (between 2008 and 2014) of adult systemic lupus erythematosus (SLE) patients at a tertiary referral centre were retrospectively screened for a clinical and echocardiographic diagnosis of lupus myocarditis...
May 25, 2016: Lupus
Mohamed Loutfi, Sanaa Ashour, Eman El-Sharkawy, Sara El-Fawal, Karim El-Touny
UNLABELLED: Assessment of left ventricular (LV) function is important for decision-making and risk stratification in patients with acute coronary syndrome. Many patients with non-ST segment elevation myocardial infarction (NSTEMI) have substantial infarction, but these patients often do not reveal clinical signs of instability, and they rarely fulfill criteria for acute revascularization therapy. AIM: This study evaluated the potential of strain Doppler echocardiography analysis for the assessment of LV infarct size when compared with standard two-dimensional echo and cardiac magnetic resonance (CMR) data...
2016: Clinical Medicine Insights. Cardiology
Dawod Sharif, Mira Abu-Salem, Amal Sharif-Rasslan, Uri Rosenschein
BACKGROUND: Patients with acute ST-elevation myocardial infarction (STEMI) and increased platelet count treated by fibrinolysis have worse outcomes. AIM: The aim of this study was to test the hypothesis that platelet blood count at admission in patients with acute STEMI treated by primary percutaneous coronary intervention affects coronary flow, myocardial perfusion and recovery of left ventricular systolic function. METHODS: A total of 174 patients presenting with acute anterior STEMI and treated with primary percutaneous coronary intervention were included and divided into subgroups of admission platelet blood count of <200 K, 200-300 K, 300-400 K and >400 K...
April 11, 2016: European Heart Journal. Acute Cardiovascular Care
Sandra Hamada, Joerg Schroeder, Rainer Hoffmann, Ertunc Altiok, Andras Keszei, Mohammad Almalla, Andreas Napp, Nikolaus Marx, Michael Becker
BACKGROUND: Cardiac magnetic resonance imaging (CMR) has been established as a powerful tool for predicting mortality. However, its application is limited by availability and various contraindications. The aim of this study was to evaluate the predictive value of layer-specific myocardial deformation analysis as assessed by strain echocardiography for cardiac events in patients with chronic ischemic left ventricular dysfunction in comparison with CMR. METHODS: Three hundred ninety patients (mean age, 63 ± 4 years; 69% men; mean left ventricular ejection fraction [LVEF], 41 ± 7%) with chronic ischemic cardiomyopathy were prospectively enrolled and underwent strain echocardiography and CMR within 3 ± 1 days...
May 2016: Journal of the American Society of Echocardiography
Mariana Faustino, Sérgio Bravo Baptista, António Freitas, Célia Monteiro, Paulo Leal, Maura Nédio, Claudia Antunes, Pedro Farto e Abreu, Victor Gil, Carlos Morais
BACKGROUND: This study aims to evaluate the relationship between IMR (Index of Microcirculatory Resistance) and the echocardiographic evolution of left ventricular (LV) systolic and diastolic performance after ST-elevation acute myocardial infarction (STEMI), undergoing primary angioplasty (P-PCI). METHODS: IMR was evaluated immediately after P-PCI. Echocardiograms were performed within the first 24 hours (Echo1) and at 3 months (Echo2): LV volumes, ejection fraction (LVEF), wall motion score index (WMSI), E/é ratio, global longitudinal strain (GLS), and left atrial volume were measured...
April 2016: Journal of Interventional Cardiology
J Vecera, M Penicka, M Eriksen, K Russell, J Bartunek, M Vanderheyden, O A Smiseth
AIMS: Cardiac resynchronization therapy (CRT) in heart failure is limited by many non-responders. This study explores whether degree of wasted left ventricular (LV) work identifies CRT responders. METHODS AND RESULTS: Twenty-one patients who received CRT according to guidelines were studied before and after 8 ± 3 months. By definition, segments that shorten in systole perform positive work, whereas segments that lengthen do negative work. Work was calculated from non-invasive LV pressure and strain by speckle tracking echocardiography...
June 2016: European Heart Journal Cardiovascular Imaging
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