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Myocardial salvage index

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https://www.readbyqxmd.com/read/28624398/prognostic-significance-of-remote-myocardium-alterations-assessed-by-quantitative-noncontrast-t1-mapping-in-st-segment-elevation-myocardial-infarction
#1
Sebastian J Reinstadler, Thomas Stiermaier, Johanna Liebetrau, Georg Fuernau, Charlotte Eitel, Suzanne de Waha, Steffen Desch, Jan-Christian Reil, Janine Pöss, Bernhard Metzler, Christian Lücke, Matthias Gutberlet, Gerhard Schuler, Holger Thiele, Ingo Eitel
OBJECTIVES: This study assessed the prognostic significance of remote zone native T1 alterations for the prediction of clinical events in a population with ST-segment elevation myocardial infarction (STEMI) who were treated by primary percutaneous coronary intervention (PPCI) and compared it with conventional markers of infarct severity. BACKGROUND: The exact role and incremental prognostic relevance of remote myocardium native T1 mapping alterations assessed by cardiac magnetic resonance (CMR) after STEMI remains unclear...
June 9, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28596216/effect-of-ischemia-duration-and-protective-interventions-on-the-temporal-dynamics-of-tissue-composition-after-myocardial-infarction
#2
Rodrigo Fernández-Jiménez, Carlos Galan-Arriola, Javier Sanchez-Gonzalez, Jaume Aguero, Gonzalo Lopez-Martin, Sandra Gomez-Talavera, Jaime Garcia-Prieto, Austin Benn, Antonio de Molina, Manuel Barreiro-Perez, Ana Martin-Garcia, Ines Garcia-Lunar, Gonzalo Pizarro, Javier Sanz, Pedro Sánchez, Valentin Fuster, Borja Ibanez
Rationale: The impact of cardioprotective strategies and ischemia duration on post ischemia/reperfusion (I/R) myocardial tissue composition (edema, myocardium at risk [MaR], infarct size [IS], salvage, intramyocardial hemorrhage [IMH] and microvascular obstruction [MVO]) is not well understood. Objective: To study the effect of ischemia duration and protective interventions on the temporal dynamics of myocardial tissue composition in a translational animal model of I/R by the use of state-of-the-art imaging technology...
June 8, 2017: Circulation Research
https://www.readbyqxmd.com/read/28595694/myocardial-damage-in-patients-with-deferred-stenting-after-stemi-a-danami-3-defer-substudy
#3
Jacob Lønborg, Thomas Engstrøm, Kiril Aleksov Ahtarovski, Lars Nepper-Christensen, Steffen Helqvist, Niels Vejlstrup, Kasper Kyhl, Mikkel Malby Schoos, Ali Ghotbi, Christoffer Göransson, Litten Bertelsen, Lene Holmvang, Frants Pedersen, Erik Jørgensen, Kari Saunamäki, Peter Clemmensen, Ole De Backer, Lene Kløvgaard, Dan Eik Høfsten, Lars Køber, Henning Kelbæk
BACKGROUND: Although some studies found improved coronary flow and myocardial salvage when stent implantation was deferred, the DANAMI-3-DEFER (Third DANish Study of Optimal Acute Treatment of Patients With ST-elevation Myocardial Infarction) did not show any improvement in clinical outcome in patients with ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PCI) and deferred stenting. OBJECTIVES: This study sought to evaluate the effect of deferred stent implantation on infarct size, myocardial salvage, and microvascular obstruction (MVO) in patients with STEMI...
June 13, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28515120/remote-ischemic-perconditioning-to-reduce-reperfusion-injury-during-acute-st-segment-elevation-myocardial-infarction-a-systematic-review-and-meta-analysis
#4
REVIEW
Shelley L McLeod, Alla Iansavichene, Sheldon Cheskes
BACKGROUND: Remote ischemic conditioning (RIC) is a noninvasive therapeutic strategy that uses brief cycles of blood pressure cuff inflation and deflation to protect the myocardium against ischemia-reperfusion injury. The objective of this systematic review was to determine the impact of RIC on myocardial salvage index, infarct size, and major adverse cardiovascular events when initiated before catheterization. METHODS AND RESULTS: Electronic searches of Medline, Embase, and Cochrane Central Register of Controlled Trials were conducted and reference lists were hand searched...
May 17, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28488317/impact-of-sleep-disordered-breathing-in-patients-with-acute-myocardial-infarction-a-retrospective-analysis
#5
Verena Gessner, Thomas Bitter, Dieter Horstkotte, Olaf Oldenburg, Henrik Fox
Sleep-disordered breathing (SDB) is associated with an increased risk of cardiovascular events. Previous studies showed that severe SDB has a negative impact on myocardial salvage and progression of left ventricular dysfunction after acute myocardial infarction (AMI). This study investigated the frequency of SDB and the effects of SDB on left ventricular function after AMI. This retrospective study enrolled all patients with AMI who had undergone cardiorespiratory polygraphy for SDB diagnosis. The apnea-hypopnea index was used as a standard metric of SDB severity...
May 10, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28474817/relationship-between-diabetes-and-ischemic-injury-among-patients-with-revascularized-st-elevation-myocardial-infarction-diabetes-and-myocardial-damage
#6
Sebastian J Reinstadler, Thomas Stiermaier, Charlotte Eitel, Bernhard Metzler, Suzanne de Waha, Georg Fuernau, Steffen Desch, Holger Thiele, Ingo Eitel
AIMS: Studies comparing reperfusion efficacy and myocardial damage between diabetic and non-diabetic patients with ST-elevation myocardial infarction (STEMI) are scarce and have reported conflicting results. Aim was to investigate the impact of preadmission diabetic status on myocardial salvage and damage as determined by cardiac magnetic resonance (CMR) and to evaluate its prognostic relevance. MATERIALS AND METHODS: We enrolled 792 patients with STEMI at eight sites...
May 5, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28439734/myocardial-salvage-after-primary-percutaneous-coronary-intervention-in-patients-with-st-elevation-myocardial-infarction-presenting-early-versus-late-after-symptom-onset
#7
Thomas Stiermaier, Ingo Eitel, Suzanne de Waha, Janine Pöss, Georg Fuernau, Holger Thiele, Steffen Desch
Primary percutaneous coronary intervention (PCI) is the treatment of choice in patients with ST-elevation myocardial infarction (STEMI) presenting within 12 h of symptom onset. A benefit in the subacute stage is less clear. The aim of the present analysis was to compare myocardial salvage and infarct size between patients with early and late reperfusion after STEMI. We compared cardiac magnetic resonance (CMR) data from a randomized controlled trial (RCT) in STEMI patients presenting within 12 h (n = 695) and a RCT of subacute STEMI patients presenting between 12 and 48 h (n = 93) after symptom onset...
April 24, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28438740/clinical-significance-of-postinfarct-fever-in-st-segment-elevation-myocardial-infarction-a-cardiac-magnetic-resonance-imaging-study
#8
Woo Jin Jang, Jeong Hoon Yang, Young Bin Song, Woo Jung Chun, Ju Hyeon Oh, Yong Hwan Park, Mi Rae Lee, Jin Kyung Hwang, Ji-Won Hwang, Joo-Yong Hahn, Seung-Hyuk Choi, Sang-Chol Lee, Yeon Hyeon Choe, Hyeon-Cheol Gwon
BACKGROUND: Little is known about causality and pathological mechanism underlying association of postinfarct fever with myocardial injury in patients with ST-segment elevation myocardial infarction. METHODS AND RESULTS: In 276 patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction, cardiac magnetic resonance imaging was performed a median of 3.4 days after the index procedure. Forty-five patients had postinfarct fever (peak body temperature within 4 days after primary percutaneous coronary intervention ≥37...
April 24, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28373244/cardioprotective-effects-of-intracoronary-morphine-in-st-segment-elevation-myocardial-infarction-patients-undergoing-primary-percutaneous-coronary-intervention-a-prospective-randomized-trial
#9
Hye Bin Gwag, Eun Kyoung Kim, Taek Kyu Park, Joo Myung Lee, Jeong Hoon Yang, Young Bin Song, Jin-Ho Choi, Seung-Hyuk Choi, Sang Hoon Lee, Sung-A Chang, Sung-Ji Park, Sang-Chol Lee, Seung Woo Park, Woo Jin Jang, Mirae Lee, Woo Jung Chun, Ju Hyeon Oh, Yong Hwan Park, Yeon Hyeon Choe, Hyeon-Cheol Gwon, Joo-Yong Hahn
BACKGROUND: A cardioprotective role of morphine acting via opioid receptors has been demonstrated, and previous preclinical studies have reported that morphine could reduce reperfusion injury and myocardial infarct size in a way similar to that of ischemic periconditioning. This study aimed to evaluate the effect of intracoronary morphine on myocardial infarct size in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention. METHODS AND RESULTS: This study was designed as a 2-center, prospective, randomized, open-label, blinded end point trial...
April 3, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28321000/the-effects-of-hydrogen-gas-inhalation-on-adverse-left-ventricular-remodeling-after-percutaneous-coronary-intervention-for-st-elevated-myocardial-infarction%C3%A3-first-pilot-study-in-humans
#10
Yoshinori Katsumata, Fumiya Sano, Takayuki Abe, Tomoyoshi Tamura, Taishi Fujisawa, Yasuyuki Shiraishi, Shun Kohsaka, Ikuko Ueda, Koichiro Homma, Masaru Suzuki, Shigeo Okuda, Yuichiro Maekawa, Eiji Kobayashi, Shingo Hori, Junichi Sasaki, Keiichi Fukuda, Motoaki Sano
BACKGROUND: Hydrogen gas inhalation (HI) reduced infarct size and mitigated adverse left ventricular (LV) remodeling in a rat model of acute myocardial infarction (AMI). We designed a prospective, open-label, rater-blinded clinical pilot study in patients experiencing ST-elevated MI (STEMI).Methods and Results:The 20 patients with an initial diagnosis of STEMI were assigned to either an HI group (1.3% H2with 26% oxygen) or a control group (26% oxygen). There were no HI-related severe adverse events...
March 17, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28264870/association-between-early-q-waves-and-reperfusion-success-in-patients-with-st-segment-elevation-myocardial-infarction-treated-with-primary-percutaneous-coronary-intervention-a-cardiac-magnetic-resonance-imaging-study
#11
Divan Gabriel Topal, Jacob Lønborg, Kiril Aleksov Ahtarovski, Lars Nepper-Christensen, Steffen Helqvist, Lene Holmvang, Frants Pedersen, Peter Clemmensen, Kari Saünamaki, Erik Jørgensen, Kasper Kyhl, Ali Ghotbi, Mikkel Malby Schoos, Christoffer Göransson, Litten Bertelsen, Dan Høfsten, Lars Køber, Henning Kelbæk, Niels Vejlstrup, Thomas Engstrøm
BACKGROUND: Pathological early Q waves (QW) are associated with adverse outcomes in patients with ST-segment-elevation myocardial infarction (STEMI). Primary percutaneous coronary intervention (PCI) may therefore be less beneficial in patients with QW than in patients without QW. Myocardial salvage index and microvascular obstruction (MVO) are markers for reperfusion success. Thus, to clarify the benefit from primary PCI in STEMI patients with QW, we examined the association between baseline QW and myocardial salvage index and MVO in STEMI patients treated with primary PCI...
March 2017: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28195949/a-preclinical-translational-study-of-the-cardioprotective-effects-of-plasma-derived-alpha-1-anti-trypsin-in-acute-myocardial-infarction
#12
Adolfo G Mauro, Eleonora Mezzaroma, Carlo Marchetti, Pratyush Narayan, Marco G Del Buono, Marialessia Capuano, Andrea Prestamburgo, Simone Catapano, Fadi N Salloum, Antonio Abbate, Stefano Toldo
BACKGROUND: The area of myocardial infarction continues to expand for hours after reperfusion. The injured but viable myocardium may be salvaged if the signals leading to cell death are interrupted. Activation of the caspase-1 inflammasome in the heart shortly after ischemia-reperfusion contributes to the final infarct size. Plasma-derived α-1 anti-trypsin (AAT) has shown to inhibit inflammasome formation in vitro and in vivo. To explore the potential translational clinical value of AAT as a therapeutic, we conducted a series of preclinical experiments designed to simulate clinically relevant scenarios...
May 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/28155873/alteration-of-multiple-leukocyte-gene-expression-networks-is-linked-with-magnetic-resonance-markers-of-prognosis-after-acute-st-elevation-myocardial-infarction
#13
A Teren, H Kirsten, F Beutner, M Scholz, L M Holdt, D Teupser, M Gutberlet, J Thiery, G Schuler, I Eitel
Prognostic relevant pathways of leukocyte involvement in human myocardial ischemic-reperfusion injury are largely unknown. We enrolled 136 patients with ST-elevation myocardial infarction (STEMI) after primary angioplasty within 12 h after onset of symptoms. Following reperfusion, whole blood was collected within a median time interval of 20 h (interquartile range: 15-25 h) for genome-wide gene expression analysis. Subsequent CMR scans were performed using a standard protocol to determine infarct size (IS), area at risk (AAR), myocardial salvage index (MSI) and the extent of late microvascular obstruction (lateMO)...
February 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28081269/morphine-does-not-affect-myocardial-salvage-in-st-segment-elevation-myocardial-infarction
#14
Hye Bin Gwag, Taek Kyu Park, Young Bin Song, Eun Kyoung Kim, Woo Jin Jang, Jeong Hoon Yang, Joo-Yong Hahn, Seung-Hyuk Choi, Jin-Ho Choi, Sang Hoon Lee, Yeon Hyeon Choe, Joonghyun Ahn, Keumhee Chough Carriere, Hyeon-Cheol Gwon
Recent studies have proposed intravenous (IV) morphine is associated with delayed action of antiplatelet agents in acute myocardial infarction. However, it is unknown whether morphine results in increased myocardial damage in ST-segment elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PCI). We investigated myocardial salvage index (MSI) to determine whether IV morphine affects myocardial injury adversely in STEMI patients undergoing primary PCI. 299 STEMI patients underwent contrast-enhanced magnetic resonance imaging a median of 3 days after PCI...
2017: PloS One
https://www.readbyqxmd.com/read/28069574/left-ventricular-hypertrophy-is-associated-with-increased-infarct-size-and-decreased-myocardial-salvage-in-patients-with-st-segment-elevation-myocardial-infarction-undergoing-primary-percutaneous-coronary-intervention
#15
Lars Nepper-Christensen, Jacob Lønborg, Kiril Aleksov Ahtarovski, Dan Eik Høfsten, Kasper Kyhl, Adam Ali Ghotbi, Mikkel Malby Schoos, Christoffer Göransson, Litten Bertelsen, Lars Køber, Steffen Helqvist, Frants Pedersen, Kari Saünamaki, Erik Jørgensen, Henning Kelbæk, Lene Holmvang, Niels Vejlstrup, Thomas Engstrøm
BACKGROUND: Approximately one third of patients with ST-segment elevation myocardial infarction (STEMI) have left ventricular hypertrophy (LVH), which is associated with impaired outcome. However, the causal association between LVH and outcome in STEMI is unknown. We evaluated the association between LVH and: myocardial infarct size, area at risk, myocardial salvage, microvascular obstruction, left ventricular (LV) function (all determined by cardiac magnetic resonance [CMR]), and all-cause mortality and readmission for heart failure in STEMI patients treated with primary percutaneous coronary intervention...
January 9, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27940956/effects-of-liraglutide-on-reperfusion-injury-in-patients-with-st-segment-elevation-myocardial-infarction
#16
RANDOMIZED CONTROLLED TRIAL
Wei Ren Chen, Yun Dai Chen, Feng Tian, Na Yang, Liu Quan Cheng, Shun Ying Hu, Jing Wang, Jun Jie Yang, Shi Feng Wang, Xiao Fang Gu
BACKGROUND: Liraglutide, a glucagon-like peptide-1 analog, was reported to reduce reperfusion injury in mice. We planned to evaluate the effects of liraglutide on reperfusion injury in patients with acute ST-segment-elevation myocardial infarction treated with primary percutaneous coronary intervention. METHODS AND RESULTS: A total of 96 patients with ST-segment-elevation myocardial infarction undergoing emergency primary percutaneous coronary intervention were randomized to receive either subcutaneous liraglutide or placebo...
December 2016: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/27893526/effect-of-oxygen-therapy-on-myocardial-salvage-in-st-elevation-myocardial-infarction-the-randomized-soccer-trial
#17
Ardavan Khoshnood, Marcus Carlsson, Mahin Akbarzadeh, Pallonji Bhiladvala, Anders Roijer, David Nordlund, Peter Höglund, David Zughaft, Lizbet Todorova, Arash Mokhtari, Håkan Arheden, David Erlinge, Ulf Ekelund
OBJECTIVE: Recent studies suggest that administration of O2 in patients with acute myocardial infarction may have negative effects. With the use of cardiac MRI (CMR), we evaluated the effects of supplemental O2 in patients with ST elevation myocardial infarction (STEMI) accepted for acute percutaneous coronary intervention (PCI). MATERIALS AND METHODS: This study was a randomized-controlled trial conducted at two university hospitals in Sweden. Normoxic STEMI patients were randomized in the ambulance to either supplemental O2 (10 l/min) or room air until the conclusion of the PCI...
November 23, 2016: European Journal of Emergency Medicine: Official Journal of the European Society for Emergency Medicine
https://www.readbyqxmd.com/read/27884851/influence-of-preinfarction-angina-and-coronary-collateral-blood-flow-on-the-efficacy-of-remote-ischaemic-conditioning-in-patients-with-st-segment-elevation-myocardial-infarction-post-hoc-subgroup-analysis-of-a-randomised-controlled-trial
#18
Kasper Pryds, Morten Bøttcher, Astrid Drivsholm Sloth, Kim Munk, Michael Rahbek Schmidt, Hans Erik Bøtker
OBJECTIVES: Remote ischaemic conditioning (RIC) confers cardioprotection in patients with ST segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (pPCI). We investigated whether preinfarction angina and coronary collateral blood flow (CCBF) to the infarct-related artery modify the efficacy of RIC. DESIGN: Post hoc subgroup analysis of a randomised controlled trial. PARTICIPANTS: A total of 139 patients with STEMI randomised to treatment with pPCI or RIC+pPCI...
November 24, 2016: BMJ Open
https://www.readbyqxmd.com/read/27832796/antecedent-hypertension-and-myocardial-injury-in-patients-with-reperfused-st-elevation-myocardial-infarction
#19
Sebastian J Reinstadler, Thomas Stiermaier, Charlotte Eitel, Mohammed Saad, Bernhard Metzler, Suzanne de Waha, Georg Fuernau, Steffen Desch, Holger Thiele, Ingo Eitel
BACKGROUND: Antecedent hypertension is associated with poor outcome in patients with ST-elevation myocardial infarction (STEMI). Whether differences in myocardial salvage, infarct size and microvascular injury contribute to the adverse outcome is unknown. We investigated the association between antecedent hypertension and cardiovascular magnetic resonance (CMR) parameters of myocardial salvage and damage in a multicenter CMR substudy of the AIDA-STEMI trial (Abciximab Intracoronary versus intravenously Drug Application in ST-elevation myocardial infarction)...
November 11, 2016: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/27823695/effect-of-remote-ischemic-conditioning-on-infarct-size-in-patients-with-anterior-st-elevation-myocardial-infarction
#20
RANDOMIZED CONTROLLED TRIAL
Dinos Verouhis, Peder Sörensson, Andrey Gourine, Loghman Henareh, Jonas Persson, Nawzad Saleh, Magnus Settergren, Martin Sundqvist, Per Tornvall, Nils Witt, Felix Böhm, John Pernow
BACKGROUND: Previous studies indicate that remote ischemic conditioning performed before percutaneous coronary intervention (PCI) reduces infarct size in patients with ST-elevation myocardial infarction (STEMI). It remains unclear whether remote conditioning affords protection when performed in adjunct to primary PCI. We aimed to study whether remote ischemic per-postconditioning (RIperpostC) initiated after admission to the catheterization laboratory attenuates myocardial infarct size in patients with anterior STEMI...
November 2016: American Heart Journal
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