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https://www.readbyqxmd.com/read/29747683/reduced-penetrance-of-the-psen1-h163y-autosomal-dominant-alzheimer-mutation-a-22-year-follow-up-study
#1
Steinunn Thordardottir, Elena Rodriguez-Vieitez, Ove Almkvist, Daniel Ferreira, Laure Saint-Aubert, Anne Kinhult-Ståhlbom, Håkan Thonberg, Michael Schöll, Eric Westman, Anders Wall, Maria Eriksdotter, Henrik Zetterberg, Kaj Blennow, Agneta Nordberg, Caroline Graff
BACKGROUND: The range of onset ages within some PSEN1 families is wide, and a few cases of reduced penetrance of PSEN1 mutations have been reported. However, published data on reduced penetrance have been limited to clinical histories, often collected retrospectively and lacking biomarker information. We present a case of reduced penetrance of the PSEN1 H163Y mutation in a carrier prospectively followed for 22 years. METHODS: Two brothers (A and B), both carriers of the H163Y mutation, were followed between 1995 and 2017...
May 10, 2018: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/29734821/cerebral-microbleeds-in-advanced-dementia-clinical-and-pathological-correlates
#2
Inmaculada Boyano, Ana Ramos, Jorge López-Alvarez, Carolina Mendoza-Rebolledo, Emma Osa-Ruiz, Irene Rodríguez, Almudena Pérez, Eva Alfayate, Belén González, Laura Fernández, Luis Agüera-Ortiz, Alberto Rábano, Javier Olazarán
OBJECTIVE: We conducted a longitudinal study to explore the clinical and pathological correlates of cerebral microbleeds (CMBs) in institutionalized patients with dementia. METHODS: Clinical and magnetic resonance imaging (MRI) data were extracted from 182 nursing home patients (mean age [standard deviation]: 81.3 [6.9], 78.0% female, and 83.4% moderate to severe dementia), which were divided according to the CMBs number and location. One-year follow-up data were obtained from 153 patients, and postmortem pathological diagnosis was available in 40 patients...
January 1, 2018: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/29686882/pyosalpinges-after-hysterosalpingography-in-a-patient-with-lower-genital-tract-infection-and-managed-by-laparoscopic-surgery-in-a-resource-low-tertiary-hospital-case-report-and-literature-review
#3
Thomas Obinchemti Egbe, Fidelia Mbi Kobenge, Metogo Mbengono Junette Arlette, Eugene Belley-Priso
Background: Pyosalpinges (a complication of pelvic inflammatory disease) is infection of the fallopian tubes and the morbidity associated with it has major health implications. We are reporting a case of pyosalpinges diagnosed after hysterosalpingography and managed by laparoscopic surgery at the Douala General Hospital, Cameroon. Case presentation: A 29-year-old single woman, an assistant nurse of the Douala tribe in Cameroon. She is G1P0010 and came to our attention because of secondary infertility of three years duration...
2018: Fertility Research and Practice
https://www.readbyqxmd.com/read/29672370/magnet%C3%A2-or-pathway%C3%A2-recognition-comparing-and-contrasting
#4
Rebecca Graystone, Christine Pabico
The Directors of the Magnet Recognition Program® and Pathway to Excellence® use this column to compare and contrast the 2 programs. Both programs profile nursing excellence.
May 2018: Journal of Nursing Administration
https://www.readbyqxmd.com/read/29644990/distraction-technique-for-pain-reduction-in-peripheral-venous-catheterization-randomized-controlled-trial
#5
Ihor Balanyuk, Giuseppina Ledonne, Marco Provenzano, Roberto Bianco, Cristina Meroni, Paola Ferri, Loris Bonetti
BACKGROUND AND AIM OF THE WORK: Procedural pain during Peripheral Venous Catheterization (PVC) is a significant issue for patients. Reducing procedure-induced pain improves the quality of care and reduces patient discomfort. We aimed to compare a non-pharmacological technique (distraction) to anaesthetic cream (EMLA) for the reduction of procedural pain during PVC, in patients undergoing Computerized Tomography (CT) or Nuclear Magnetic Resonance (NMR) with contrast. METHODS: This is a Prospective, Randomized Controlled Trial...
February 21, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29644942/postnatal-undernutrition-in-mice-causes-cardiac-arrhythmogenesis-which-is-exacerbated-when-pharmacologically-stressed
#6
J R Visker, D P Ferguson
Growth restriction caused by postnatal undernutrition increases risk for cardiovascular disease in adulthood with the potential to induce arrhythmogenesis. Thus, the purpose was to determine if undernutrition during development produced arrhythmias at rest and when stressed with dobutamine in adulthood. Mouse dams were fed (CON: 20% protein), or low-protein (LP: 8%) diet before mating. A cross-fostering model was used where pups nursed by dams fed LP diet in early [EUN; postnatal day (PN) 1-10], late (LUN; PN11-21) and whole (PUN; 1-21) phases of postnatal life...
April 12, 2018: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/29629911/national-study-of-nursing-research-characteristics-at-magnet%C3%A2-designated-hospitals
#7
Christine Pintz, Qiuping Pearl Zhou, Maureen Kirkpatrick McLaughlin, Katherine Patterson Kelly, Cathie E Guzzetta
OBJECTIVE: To describe the research infrastructure, culture, and characteristics of building a nursing research program in Magnet®-designated hospitals. BACKGROUND: Magnet recognition requires hospitals to conduct research and implement evidence-based practice (EBP). Yet, the essential characteristics of productive nursing research programs are not well described. METHODS: We surveyed 181 nursing research leaders at Magnet-designated hospitals to assess the characteristics in their hospitals associated with research infrastructure, research culture, and building a nursing research program...
May 2018: Journal of Nursing Administration
https://www.readbyqxmd.com/read/29613859/magnetic-work-environments-patient-experience-outcomes-in-magnet-versus-non-magnet-hospitals
#8
Deirdre McCaughey, Gwen E McGhan, Cheryl Rathert, Jessica H Williams, Kristine R Hearld
BACKGROUND: The term Magnet hospital is an official designation ascribed by the American Nurses Credentialing Center for hospitals that meet specific criteria indicating they have a "magnetic work environment" for nurses. The objective of the Magnet designation is to encourage hospitals to design work in such a way as to attract and retain high-quality nurses and thus improve the quality of patient care. Empirical research has demonstrated that hospitals who earn a Magnet designation appear to have nurses who are more satisfied and committed to their work environments...
April 2, 2018: Health Care Management Review
https://www.readbyqxmd.com/read/29576902/maladjustment-of-programmable-ventricular-shunt-valves-by-inadvertent-exposure-to-a-common-hospital-device
#9
R Fujimura, R Lober, K Kamian, L Kleiner
Background: Programmable ventricular shunt valves are commonly used to treat hydrocephalus. They can be adjusted to allow for varying amounts of cerebrospinal fluid (CSF) flow using an external magnetic programming device, and are susceptible to maladjustment from inadvertent exposure to magnetic fields. Case Description: We describe the case of a 3-month-old girl treated for hydrocephalus with a programmable StrataTM II valve found at the incorrect setting on multiple occasions during her hospitalization despite frequent reprogramming and surveillance...
2018: Surgical Neurology International
https://www.readbyqxmd.com/read/29570503/a-nursing-partnership-to-accelerate-academic-progression
#10
Sharon Kumm, Delois Laverentz
Associate degree nursing faculty in a Midwestern state reported that their students were being excluded from many clinical experiences and that their graduates were not being hired in Magnet® or Magnet-seeking hospitals. University and community college faculty formed a partnership to promote academic progression. Barriers of residency requirements, financial aid, and accreditation were overcome. Students complete all BSN prerequisites, take ADN and BSN courses simultaneously, graduate with both degrees, and take the national licensure examination...
March 22, 2018: Nursing Education Perspectives
https://www.readbyqxmd.com/read/29570142/so-you-re-thinking-about-the-journey-to-magnet%C3%A2-recognition%C3%A2
#11
Rebecca Graystone
The Director of the Magnet Recognition Program® presents a list of resources available to organizations either on the journey to Magnet® or contemplating setting this prestigious designation of nursing excellence as a goal.
April 2018: Journal of Nursing Administration
https://www.readbyqxmd.com/read/29560626/applicability-of-active-infrared-thermography-for-screening-of-human-breast-a-numerical-study
#12
Geetika Dua, Ravibabu Mulaveesala
Active infrared thermography is a fast, painless, noncontact, and noninvasive imaging method, complementary to mammography, ultrasound, and magnetic resonance imaging methods for early diagnosis of breast cancer. This technique plays an important role in early detection of breast cancer to women of all ages, including pregnant or nursing women, with different sizes of breast, irrespective of either fatty or dense breast. This proposed complementary technique makes use of infrared emission emanating from the breast...
March 2018: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29548553/interventional-radiation-oncology-iro-transition-of-a-magnetic-resonance-simulator-to-a-brachytherapy-suite
#13
Roberta Anderson, Elwood Armour, Courtney Beeckler, Valerie Briner, Amanda Choflet, Andrea Cox, Amanda N Fader, Marie N Hannah, Robert Hobbs, Ellen Huang, Marilyn Kiely, Junghoon Lee, Marc Morcos, Paige E McMillan, Dave Miller, Sook Kien Ng, Rashmi Prasad, Annette Souranis, Robert Thomsen, Theodore L DeWeese, Akila N Viswanathan
PURPOSE: As a core component of a new gynecologic cancer radiation program, we envisioned, structured, and implemented a novel Interventional Radiation Oncology (IRO) unit and magnetic resonance (MR)-brachytherapy environment in an existing MR simulator. METHODS AND MATERIALS: We describe the external and internal processes required over a 6-8 month time frame to develop a clinical and research program for gynecologic brachytherapy and to successfully convert an MR simulator into an IRO unit...
March 13, 2018: Brachytherapy
https://www.readbyqxmd.com/read/29544651/hospital-nursing-leadership-led-interventions-increased-genomic-awareness-and-educational-intent-in-magnet-settings
#14
Kathleen A Calzone, Jean Jenkins, Stacey Culp, Laurie Badzek
BACKGROUND: The Precision Medicine Initiative will accelerate genomic discoveries that improve health care, necessitating a genomic competent workforce. PURPOSE: This study assessed leadership team (administrator/educator) year-long interventions to improve registered nurses' (RNs) capacity to integrate genomics into practice. METHODS: We examined genomic competency outcomes in 8,150 RNs. DISCUSSION: Awareness and intention to learn more increased compared with controls...
November 13, 2017: Nursing Outlook
https://www.readbyqxmd.com/read/29536101/health-care-spending-in-the-united-states-and-other-high-income-countries
#15
Irene Papanicolas, Liana R Woskie, Ashish K Jha
Importance: Health care spending in the United States is a major concern and is higher than in other high-income countries, but there is little evidence that efforts to reform US health care delivery have had a meaningful influence on controlling health care spending and costs. Objective: To compare potential drivers of spending, such as structural capacity and utilization, in the United States with those of 10 of the highest-income countries (United Kingdom, Canada, Germany, Australia, Japan, Sweden, France, the Netherlands, Switzerland, and Denmark) to gain insight into what the United States can learn from these nations...
March 13, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29528194/multisite-studies-demonstrate-positive-relationship-between-practice-environments-and-smoking-cessation-counseling-evidence-based-practices
#16
Robin Newhouse, Ha Do Byon, Emily Storkman Wolf, Meg Johantgen
PROBLEM: High-quality smoking cessation counseling guidelines for people who use tobacco are not fully integrated in acute-care services presenting missed opportunities to improve health outcomes. The role of the practice environment on enhancing or inhibiting guideline use is unknown. OBJECTIVE: To examine the relationship between the nurse practice environment and nurses' use of smoking cessation counseling practices, and to evaluate the effect of the individual nurse and organization characteristics on nurse smoking cessation counseling practices...
March 12, 2018: Worldviews on Evidence-based Nursing
https://www.readbyqxmd.com/read/29527399/nursing-review-of-spinal-meningiomas
#17
REVIEW
Nancy E Epstein
Background: Spinal meningiomas are found in patients typically between the ages of 75 and 84: some report the average age to be 50. They occur with an incidence of approximately 1000 patients per year in the US, are mostly single (90%) rather than multiple (10%), and arise from the spinal meninges (arachnoid/dura). Tumors are typically posterior/posterolateral (70%) in location, leaving the remaining 30% in the anterior/anterolateral spinal canal. They produce symptoms and signs of radiculopathy (nerve root) and/or myelopathy (cord compression) depending on their site of origin...
2018: Surgical Neurology International
https://www.readbyqxmd.com/read/29523981/healthcare-efficiency-assessment-using-dea-analysis-in-the-slovak-republic
#18
Robert Stefko, Beata Gavurova, Kristina Kocisova
A regional disparity is becoming increasingly important growth constraint. Policy makers need quantitative knowledge to design effective and targeted policies. In this paper, the regional efficiency of healthcare facilities in Slovakia is measured (2008-2015) using data envelopment analysis (DEA). The DEA is the dominant approach to assessing the efficiency of the healthcare system but also other economic areas. In this study, the window approach is introduced as an extension to the basic DEA models to evaluate healthcare technical efficiency in individual regions and quantify the basic regional disparities and discrepancies...
March 9, 2018: Health Economics Review
https://www.readbyqxmd.com/read/29514586/an-integrative-review-of-bullying-and-lateral-violence-among-nurses-in-magnet%C3%A2-organizations
#19
Lauren E Pfeifer, Judith A Vessey
Over the past several years, researchers have postulated that Magnet® organizations improve collegiality and potentially could mitigate workplace bullying and lateral violence (BLV). In order to synthesize and evaluate the existing literature on BLV in the Magnet® setting, an integrative review was conducted. The final analysis consisted of 11 articles (8 quantitative and 3 qualitative studies) and revealed that researchers still use a variety of terms to define and measure BLV. Several of the studies used blended samples of both Magnet® and non-Magnet nurses, making it difficult to evaluate for response differences...
August 2017: Policy, Politics & Nursing Practice
https://www.readbyqxmd.com/read/29510685/case-report-8-years-after-liver-transplantation-de-novo-hepatocellular-carcinoma-8-months-after-hcv-clearance-through-ifn-free-antiviral-therapy
#20
Giuliano Ramadori, Patrizia Bosio, Federico Moriconi, Ihtzaz A Malik
BACKGROUND: After orthotopic liver transplantation (OLT) for hepatocellular carcinoma (HCC), recurrent HCC mostly develops within 2 years. All cases of de novo HCC described so far occurred later than 2 years after OLT. Prevention of post-transplantation HCC has usually been tried to achieve by curing or controlling recurrent liver disease. This has been rationale for treatment with interferon (IFN)/ribavirin of HCV-recurrence in patients after OLT, transplanted for advanced HCV-induced liver disease and/or HCC...
March 6, 2018: BMC Cancer
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