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https://www.readbyqxmd.com/read/28482435/-expression-of-nf-%C3%AE%C2%BAb-in-a-degenerative-human-intervertebral-disc-model
#1
X F Wang, A P Zhang, Z Y Sun, C Liu, L H Kuang, J W Tian
Objective: To investigate the changes in the expression of NF-κB signaling pathway in human degenerative intervertebral discs. Methods: From October 2014 to March 2016, 55 nucleus pulposus of surgical patients with degenerative human intervertebral disc were collected for study in Department of Orthopedic Surgey, Hospital of Zaozhuang Mining Corporation, and Department of Orthopedics, Shanghai General Hospital Affiliated Shanghai Jiaotong University, School of Medicine.The collected nucleus pulposus tissues were divided into two groups: experimental group(30) and control group(25)...
May 9, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28413347/a-biochemo-mechano-coupled-computational-model-combining-membrane-transport-and-pericellular-proteolysis-in-tissue-mechanics
#2
A-T Vuong, A D Rauch, W A Wall
We present a computational model for the interaction of surface- and volume-bound scalar transport and reaction processes with a deformable porous medium. The application in mind is pericellular proteolysis, i.e. the dissolution of the solid phase of the extracellular matrix (ECM) as a response to the activation of certain chemical species at the cell membrane and in the vicinity of the cell. A poroelastic medium model represents the extra cellular scaffold and the interstitial fluid flow, while a surface-bound transport model accounts for the diffusion and reaction of membrane-bound chemical species...
March 2017: Proceedings. Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/28281249/immunosensing-with-near-infrared-plasmonic-optical-fiber-gratings
#3
Christophe Caucheteur, Clotilde Ribaut, Viera Malachovska, Ruddy Wattiez
Surface Plasmon resonance (SPR) optical fiber biosensors constitute a miniaturized counterpart to the bulky prism configuration and offer remote operation in very small volumes of analyte. They are a cost-effective and relatively straightforward technique to yield in situ (or even possibly in vivo) molecular detection. They are usually obtained from a gold-coated fiber segment for which the core-guided light is brought into contact with the surrounding medium, either by etching (or side-polishing) or by using grating coupling...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28087487/bioprinting-for-vascular-and-vascularized-tissue-biofabrication
#4
REVIEW
Pallab Datta, Bugra Ayan, Ibrahim T Ozbolat
Bioprinting is a promising technology to fabricate design-specific tissue constructs due to its ability to create complex, heterocellular structures with anatomical precision. Bioprinting enables the deposition of various biologics including growth factors, cells, genes, neo-tissues and extra-cellular matrix-like hydrogels. Benefits of bioprinting have started to make a mark in the fields of tissue engineering, regenerative medicine and pharmaceutics. Specifically, in the field of tissue engineering, the creation of vascularized tissue constructs has remained a principal challenge till date...
January 11, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28073559/characterization-of-total-retinoid-like-activity-of-compounds-produced-by-three-common-phytoplankton-species
#5
Eliška Sychrová, Jana Priebojová, Marie Smutná, Kateřina Nováková, Jiří Kohoutek, Klára Hilscherová
Phytoplankton can produce various bioactive metabolites, which may affect other organisms in the aquatic environment. This study provides the first information on the total retinoid-like activity associated with both intracellular and extracellular metabolites produced by selected phytoplankton species that could play a role in teratogenic effects and developmental disruption in exposed organisms. The studied species included a coccoid cyanobacteria (Microcystis aeruginosa), a filamentous cyanobacteria (Aphanizomenon gracile) and a green alga (Desmodesmus quadricauda), all of which commonly occur in freshwater bodies in Europe...
December 2016: Harmful Algae
https://www.readbyqxmd.com/read/28039592/loss-or-mislocalization-of-aquaporin-4-affects-diffusion-properties-and-intermediary-metabolism-in-gray-matter-of-mice
#6
T Pavlin, E A Nagelhus, C Brekken, E M Eyjolfsson, A Thoren, O Haraldseth, U Sonnewald, O P Ottersen, A K Håberg
The first aim of this study was to determine how complete or perivascular loss of aquaporin-4 (AQP4) water channels affects membrane permeability for water in the mouse brain grey matter in the steady state. Time-dependent diffusion magnetic resonance imaging was performed on global Aqp4 knock out (KO) and α-syntrophin (α-syn) KO mice, in the latter perivascular AQP4 are mislocalized, but still functioning. Control animals were corresponding wild type (WT) mice. By combining in vivo diffusion measurements with the effective medium theory and previously measured extra-cellular volume fractions, the effects of membrane permeability and extracellular volume fraction were uncoupled for Aqp4 and α-syn KO...
January 2017: Neurochemical Research
https://www.readbyqxmd.com/read/27993655/chitosan-based-nanofibers-in-bone-tissue-engineering
#7
REVIEW
K Balagangadharan, S Dhivya, N Selvamurugan
Bone tissue engineering involves biomaterials, cells and regulatory factors to make biosynthetic bone grafts with efficient mineralization for regeneration of fractured or damaged bones. Out of all the techniques available for scaffold preparation, electrospinning is given priority as it can fabricate nanostructures. Also, electrospun nanofibers possess unique properties such as the high surface area to volume ratio, porosity, stability, permeability and morphological similarity to that of extra cellular matrix...
December 18, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27879037/nanomembrane-based-thermal-transport-biosensor-for-living-cells
#8
Rami T ElAfandy, Ayman F AbuElela, Pawan Mishra, Bilal Janjua, Hassan M Oubei, Ulrich Büttner, Mohammed A Majid, Tien Khee Ng, Jasmeen S Merzaban, Boon S Ooi
Knowledge of materials' thermal-transport properties, conductivity and diffusivity, is crucial for several applications within areas of biology, material science and engineering. Specifically, a microsized, flexible, biologically integrated thermal transport sensor is beneficial to a plethora of applications, ranging across plants physiological ecology and thermal imaging and treatment of cancerous cells, to thermal dissipation in flexible semiconductors and thermoelectrics. Living cells pose extra challenges, due to their small volumes and irregular curvilinear shapes...
November 23, 2016: Small
https://www.readbyqxmd.com/read/27863840/long-term-pre-treatment-of-antioxidant-ginkgo-biloba-extract-egb-761-attenuates-cerebral-ischemia-induced-neuronal-damage-in-aged-mice
#9
Xiaomei Zhou, Yinliang Qi, Ting Chen
Antioxidant activity has been attributed to the neuroprotective effects of Ginkgo biloba extract EGb-761 on brain disorders including ischemic stroke. It is suggested that oxidative stress implicates in neuron injuries during aging. However, whether or not EGb-761 could be used to treat age-related cerebral ischemia is unclear. In the present study, we directly studied the protective effects of EGb-761 in brain ischemia in the mice with different age. As expected, the recovery from brain damages was impaired in aged mice (24 months) in an animal model of middle cerebral artery occlusion (MCAO)...
January 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27794025/effect-of-contrast-dose-in-the-quantification-of-myocardial-extra-cellular-volume-in-adenosine-stress-rest-perfusion-cardiac-magnetic-resonance-examinations
#10
Meylin Caballeros, Pablo Bartolomé, Óscar Fernández González, Andreas Greiser, Loreto García Del Barrio, Jesús Pueyo, Gorka Bastarrika
Background Diffuse myocardial fibrosis can be quantified by calculating extra-cellular volume (ECV) from native and post-contrast T1 values using dedicated single bolus contrast medium injection protocols. Purpose To evaluate differences in T1 maps and myocardial ECV measurements in routine stress/rest perfusion cardiovascular magnetic resonance (CMR) examinations after injection of single and double dose of contrast medium. Material and Methods Thirty-seven consecutive patients (30 men; mean age, 62 ± 13 years) underwent clinically indicated adenosine stress/rest perfusion CMR examination to rule out myocardial ischemia following a conventional split-dose contrast medium injection strategy...
January 1, 2016: Acta Radiologica
https://www.readbyqxmd.com/read/27736872/a-new-strategy-for-fast-mri-based-quantification-of-the-myelin-water-fraction-application-to-brain-imaging-in-infants
#11
Sofya Kulikova, Lucie Hertz-Pannier, Ghislaine Dehaene-Lambertz, Cyril Poupon, Jessica Dubois
The volume fraction of water related to myelin (fmy) is a promising MRI index for in vivo assessment of brain myelination, that can be derived from multi-component analysis of T1 and T2 relaxometry signals. However, existing quantification methods require rather long acquisition and/or post-processing times, making implementation difficult both in research studies on healthy unsedated children and in clinical examinations. The goal of this work was to propose a novel strategy for fmy quantification within acceptable acquisition and post-processing times...
2016: PloS One
https://www.readbyqxmd.com/read/27689106/the-evaluation-of-relationship-between-blood-pressure-and-dialysate-na-concentration-in-chronic-hemodialysis-patients
#12
Narges Sadat Zahed, Omid Gharooi, Latif Gachkar, Hajar Nikbakht
INTRODUCTION: Hypertension is one of the traditional risk factors of cardiovascular disease (CVD). Extra cellular volume expansion and Na retention remain the main cause of hypertension. OBJECTIVES: The aim of this study was to investigate the relation between concentration of Na dialysate and blood pressure (BP) in chronic hemodialysis (HD) patient. PATIENTS AND METHODS: This cross-sectional study was performed on 266 adult patients undergoing HD for at least three months...
2016: Journal of Renal Injury Prevention
https://www.readbyqxmd.com/read/27617972/robust-yet-fragile-expression-noise-protein-misfolding-and-gene-dosage-in-the-evolution-of-genomes
#13
REVIEW
J Chris Pires, Gavin C Conant
The complex manner in which organisms respond to changes in their gene dosage has long fascinated geneticists. Oddly, although the existence of dominance implies that dosage reductions often have mild phenotypes, extra copies of whole chromosomes (aneuploidy) are generally strongly deleterious. Even more paradoxically, an extra copy of the genome is better tolerated than is aneuploidy. We review the resolution of this paradox, highlighting the roles of biochemistry, protein aggregation, and disruption of cellular microstructure in that explanation...
November 23, 2016: Annual Review of Genetics
https://www.readbyqxmd.com/read/27460767/prognostic-value-of-t1-mapping-in-tavr-patients-extra-cellular-volume-as-a-possible-predictor-for-peri-and-post-tavr-adverse-events
#14
Jonathan Nadjiri, Hanna Nieberler, Eva Hendrich, Albrecht Will, Costanza Pellegrini, Oliver Husser, Christian Hengstenberg, Andreas Greiser, Stefan Martinoff, Martin Hadamitzky
The benefit of a transcatheter aortic valve replacement (TAVR) can differ in patients, and therapy bears severe risks. High-degree aortic stenosis can lead to cardiac damage such as diffuse myocardial fibrosis, evaluable by extra-cellular volume (ECV) in CMR. Therefore, fibrosis might be a possible risk factor for unfavorable outcome after TAVR. We sought to assess the prognostic value of T1-mapping and ECV to predict adverse events during and after TAVR. The study population consisted of patients undergoing clinically indicated TAVR by performing additional CMR with native and contrast-enhanced T1-mapping sequences for additional evaluation of ECV...
November 2016: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/27435339/dose-enhancement-effects-to-the-nucleus-and-mitochondria-from-gold-nanoparticles-in-the-cytosol
#15
A L McNamara, W W Y Kam, N Scales, S J McMahon, J W Bennett, H L Byrne, J Schuemann, H Paganetti, R Banati, Z Kuncic
Gold nanoparticles (GNPs) have shown potential as dose enhancers for radiation therapy. Since damage to the genome affects the viability of a cell, it is generally assumed that GNPs have to localise within the cell nucleus. In practice, however, GNPs tend to localise in the cytoplasm yet still appear to have a dose enhancing effect on the cell. Whether this effect can be attributed to stress-induced biological mechanisms or to physical damage to extra-nuclear cellular targets is still unclear. There is however growing evidence to suggest that the cellular response to radiation can also be influenced by indirect processes induced when the nucleus is not directly targeted by radiation...
August 21, 2016: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/27320115/-the-influence-of-change-in-body-water-distribution-caused-by-changing-position-upon-nocturia-in-older-men
#16
Keisuke Kiba, Akihide Hirayama, Motokiyo Yoshikawa, Yutaka Yamamoto, Kazumasa Torimoto, Kiyohide Fujimoto, Hirotsugu Uemura
A total of 29 men 60 years and older (mean age 74 years) who complained at least once about nocturnal voiding and were diagnosed with nocturnal polyuria in the frequency volume chart (FVC) were enrolled in this study. Body water was measured by bioelectric impedance analysis just after lying down at 4 pm and after raising legs 30 minutes later. Nocturnal urine production was measured by FVC, and urine production per unit of time at first nocturnal voiding (urine volume at first nocturnal voiding/hours of undisturbed sleep (HUS) : UFN/HUS), urine production per unit of time during sleep (total nocturnal urine volume/hours of sleep : TNV/HS), etc was evaluated...
May 2016: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/27078862/noddi-and-tensor-based-microstructural-indices-as-predictors-of-functional-connectivity
#17
Fani Deligianni, David W Carmichael, Gary H Zhang, Chris A Clark, Jonathan D Clayden
In Diffusion Weighted MR Imaging (DWI), the signal is affected by the biophysical properties of neuronal cells and their relative placement, as well as extra-cellular tissue compartments. Typically, microstructural indices, such as fractional anisotropy (FA) and mean diffusivity (MD), are based on a tensor model that cannot disentangle the influence of these parameters. Recently, Neurite Orientation Dispersion and Density Imaging (NODDI) has exploited multi-shell acquisition protocols to model the diffusion signal as the contribution of three tissue compartments...
2016: PloS One
https://www.readbyqxmd.com/read/26956095/vitronectin-based-biomimetic-encapsulating-hydrogel-scaffolds-support-adipogenesis-of-adipose-stem-cells
#18
Tracy N Clevenger, Cassidy R Hinman, Rebekah K Ashley Rubin, Kate Smither, Daniel J Burke, Craig J Hawker, Darin Messina, Dennis Van Epps, Dennis O Clegg
Soft tissue defects are relatively common, yet currently used reconstructive treatments have varying success rates, and serious potential complications such as unpredictable volume loss and reabsorption. Human adipose-derived stem cells (ASCs), isolated from liposuction aspirate have great potential for use in soft tissue regeneration, especially when combined with a supportive scaffold. To design scaffolds that promote differentiation of these cells down an adipogenic lineage, we characterized changes in the surrounding extracellular environment during adipogenic differentiation...
April 2016: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/26792552/brain-intra-and-extracellular-sodium-concentration-in-multiple-sclerosis-a-7-t-mri-study
#19
Maria Petracca, Roxana O Vancea, Lazar Fleysher, Laura E Jonkman, Niels Oesingmann, Matilde Inglese
Intra-axonal accumulation of sodium ions is one of the key mechanisms of delayed neuro-axonal degeneration that contributes to disability accrual in multiple sclerosis. In vivo sodium magnetic resonance imaging studies have demonstrated an increase of brain total sodium concentration in patients with multiple sclerosis, especially in patients with greater disability. However, total sodium concentration is a weighted average of intra- and extra-cellular sodium concentration whose changes reflect different tissue pathophysiological processes...
March 2016: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/26771318/analysis-of-arterial-and-venous-blood-gases-in-healthy-gyr-falcons-falco-rusticolus-under-anesthesia
#20
Raj Raghav, Rachael Middleton, Rinshiya Ahamed BSc, Raji Arjunan, Valentina Caliendo
Arterial and venous blood gas analysis is useful in the assessment of tissue oxygenation and ventilation and in diagnosis of metabolic and respiratory derangements. It can be performed with a relatively small volume of blood in avian patients under emergency situations. Arterial and venous blood gas analysis was performed in 30 healthy gyr falcons ( Falco rusticolus ) under anaesthesia to establish temperature-corrected reference intervals for arterial blood gas values and to compare them to temperature-corrected venous blood gas values with a portable point-of-care blood gas analyzer (i-STAT 1, Abbott Laboratories, Abbott Park, IL, USA)...
December 2015: Journal of Avian Medicine and Surgery
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