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Vitamin D in psychiatric illness

Lakshminarayana Chekuri, Purushottam B Thapa, Carolyn L Turturro, Dinesh Mittal, Erick Messias
OBJECTIVE: To describe the prevalence of vitamin D deficiency in psychiatric inpatients with serious mental illness. Associated clinical and sociodemographic factors are also explored. METHOD: Data were collected using a retrospective review of medical records. Eligible subjects were individuals aged ≥ 18 years who were consecutively newly admitted to an adult inpatient teaching unit of a state psychiatric hospital from July 2012 through August 2013. The main outcome measure was prevalence rate of vitamin D deficiency in the target population...
2015: Primary Care Companion to CNS Disorders
Qiang Zeng, Timothy Dellenbaugh, Martin Maldonado, Joseph Moon, Rob Hornstra
BACKGROUND: Vitamin D deficiency is a re-emerging epidemic in North America. It is increasingly linked to the pathology of cognition and mental illness and is also common in psychiatric patients. AIMS: This study was designed to determine the prevalence of vitamin D deficiency among psychiatric inpatients in Kansas City, to explore the association between vitamin D status and clinical characteristics, and to identify the association of medical problems related to vitamin D deficiency in mental illness...
2016: Nordic Journal of Psychiatry
Raoul Belzeaux, Laurent Boyer, El Chérif Ibrahim, François Féron, Marion Leboyer, Guillaume Fond
Patients with psychiatric disorders display high levels of hypovitaminosis D (<50nmol/L). It remains unclear whether it is associated with specific diagnoses. To further explore vitamin D status in psychiatric inpatients, 82 individuals with mood disorders or schizophrenia/schizoaffective disorders were included. Hypovitaminosis D was significantly lower in patients with mood disorders than patients with schizophrenia (standardized β coefficient=0.385, p=0.007). Further studies are warranted to determine specific causes of hypovitaminosis D and the interest of supplementation...
September 30, 2015: Psychiatry Research
Najla J Alhraiwil, Anna Ali, Mowafa S Househ, Ali M Al-Shehri, Ashraf A El-Metwally
OBJECTIVE: To assess the epidemiology of attention deficit hyperactivity disorder (ADHD) in Arab countries, and identify gaps for future research. METHODS: We searched PubMed from July 1978 to July 2014 and reviewed local journals with cross-referencing. The keywords we used were ADHD, diagnosis, prevalence, incidence, factor, diagnosis, rate, risk, and each of the names of the 22 Arab countries (Jordan, Egypt, Lebanon, Saudi Arabia, and so on). Studies were eligible for inclusion if they investigated the epidemiology of ADHD in any Arab country, and were published in English...
April 2015: Neurosciences: the Official Journal of the Pan Arab Union of Neurological Sciences
Uté Vollmer-Conna, Erin Cvejic, Isabelle Granville Smith, Dusan Hadzi-Pavlovic, Gordon Parker
Depression in the context of acute coronary syndrome (ACS) is understood to confer increased morbidity and mortality risk. The pathophysiological mechanisms underlying this association remain poorly understood, although several candidates including inflammation, cardiac autonomic dysregulation, and behavioural factors are viewed as of key importance. No single bio-behavioural explanatory model of ACS-associated depression has emerged, likely due the substantial heterogeneity across both conditions. We studied 344 patients with ACS; 45 fulfilled diagnostic (DSM-IV) criteria for a major depressive episode occurring within 1-month of ACS, and 13 had ongoing major depression that pre-dated ACS and continued through to 1 month post-ACS...
August 2015: Brain, Behavior, and Immunity
N B Lundin, M J Niciu, D A Luckenbaugh, D F Ionescu, E M Richards, J L Vande Voort, N E Brutsche, R Machado-Vieira, C A Zarate
INTRODUCTION: Deficiencies in both vitamin B12 and folate have been associated with depression. Recently, higher baseline vitamin B12 levels were observed in individuals with bipolar depression who responded to the antidepressant ketamine at 7 days post-infusion. This study sought to -replicate this result by correlating peripheral vitamin levels with ketamine's antidepressant efficacy in bipolar depression and major depressive disorder (MDD). METHODS: Baseline vitamin B12 and folate levels were obtained in 49 inpatients with treatment-resistant MDD and 34 inpatients with treatment-resistant bipolar depression currently experiencing a major depressive episode...
July 2014: Pharmacopsychiatry
Julia J Rucklidge, Jeanette Johnstone, Brigette Gorman, Anna Boggis, Christopher M Frampton
BACKGROUND: To date there has been no research investigating moderators of response to micronutrient treatment of mental illness, specifically baseline nutrient levels. METHOD: We conducted analyses of data from a randomized placebo-controlled trial (RCT) of 80 adults (≥16years) with Attention-Deficit/Hyperactivity Disorder (ADHD), whereby participants were treated acutely (8weeks) with micronutrients or placebo followed by an open-label (OL) phase of 8weeks whereby all participants received micronutrients...
April 3, 2014: Progress in Neuro-psychopharmacology & Biological Psychiatry
Matthieu Crews, John Lally, Poonam Gardner-Sood, Oliver Howes, Stefania Bonaccorso, Shubulade Smith, Robin M Murray, Marta Di Forti, Fiona Gaughran
BACKGROUND: Vitamin D deficiency is seen in a high proportion of people with established psychotic disorders, but it is not known if this is present at onset of the illness. We set out to examine vitamin D levels in people with their first episode of psychosis (FEP). METHOD: We conducted a matched case-control study to examine vitamin D levels and rates of vitamin D deficiency in sixty nine patients presenting with their FEP and sixty nine controls matched for age, sex and ethnicity...
November 2013: Schizophrenia Research
Martino Belvederi Murri, Matteo Respino, Mattia Masotti, Marco Innamorati, Valeria Mondelli, Carmine Pariante, Mario Amore
Individuals with psychotic disorders are more likely to have vitamin D (VD) deficiency, while evidence suggests VD could have pathophysiological roles. We summarized meta-analytically the available evidence on VD levels in psychotic disorders in comparison with healthy controls and other psychiatric illnesses. We found seven studies, all reporting insufficient VD levels in patients with psychosis. Schizophrenia had a medium effect size for lower VD than healthy controls, and a trend for lower levels than other psychoses...
October 2013: Schizophrenia Research
Melanie Rylander, Steven Verhulst
OBJECTIVE: The extraskeletal effects of vitamin D have gained increasing attention with the discovery of receptors in a variety of organ systems. Previous work has identified associations between vitamin D insufficiency and a variety of mental illnesses, including affective, cognitive, and psychotic spectrum disorders. We attempted to determine the point prevalence of vitamin D insufficiency among psychiatric inpatients and determine if there was a relationship between vitamin D insufficiency and specific diagnoses and pharmacological treatments...
July 2013: Journal of Psychiatric Practice
Laura Kevere, Santa Purvina, Daiga Bauze, Marcis Zeibarts, Raisa Andrezina, Linda Piekuse, Edgars Brekis, Indulis Purvins
BACKGROUND: High level of homocysteine (Hcy) is risk factor of schizophrenia and mood disorders. AIM: The aim was to detect a serum level of Hcy, examine the associations between the level of Hcy, methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism and clinical properties for patients with schizophrenia, mood disorders and in a control group. MATERIAL AND METHODS: There were 88 patients with schizophrenia, 28 with affective disorders and 94 from the control group...
February 2014: Nordic Journal of Psychiatry
N A Bokhan, A F Abolonin, I É Ankudinova, D I Kurgak, A I Mandel'
AIM: To evaluate the efficacy of Remaxol used to treat post-withdrawal disorders in alcoholic patients with comorbid liver damage. SUBJECTS AND METHODS: The authors assessed the severity of clinical parameters, such as pathological craving and anhedonia, biochemical parameters (bilirubin, alanine aminotransferase (ALT), and aspartate aminotransferase (AST)) in 120 patients aged 30-60 years in the stage of remission formation. The patients were divided into two groups: 1) 62 patients received Remaxol; 2) 58 persons took placebo (a comparative group)...
2012: Terapevticheskiĭ Arkhiv
David D Leedahl, Julie L Cunningham, Matthew T Drake, Curt B Mundis, Simon Kung, Mark A Frye, Maria I Lapid
OBJECTIVE: The association of hypovitaminosis D with measures of depressive symptoms and cognitive impairment remains unclear. This correlation and subsequent prescribing practices of vitamin D supplementation were evaluated in a population of psychiatric inpatients. METHODS: A retrospective study was conducted of 548 patients with a serum 25-hydroxyvitamin D [25(OH)D] level measured during hospitalization. Outcomes included the association of hypovitaminosis D with Patient Health Questionnaire (PHQ-9) and Folstein Mini-Mental State Exam (MMSE) scores, including an evaluation of vitamin D dosing upon hospital discharge...
May 2013: Psychosomatics
Jill Murie, Claudia-Martina Messow, Bridie Fitzpatrick
Neuroleptic and anti-epileptic medication, inadequate vitamin D intake and limited solar exposure increase the risk of vitamin D deficiency in high security psychiatric environments. Of the 33 inpatients (40% selected; 21% of hospital population) completing this cross-sectional study, 36% had insufficient and 58% deficient vitamin D. Five patients with vitamin D deficiency had secondary hyperparathyroidism, two of whom had osteopenia on dual-emission X-ray absorptiometry. At 1-year follow up, of the 31 patients eligible, 15 had accepted and continued supplements...
November 2012: Journal of Forensic and Legal Medicine
Robert E McCue, Richard A Charles, Geraldine C M Orendain, Michel D Joseph, James O Abanishe
OBJECTIVE: Previous studies in northern Europe and Australia have indicated that vitamin D deficiency is common in psychiatric patients. This study aimed to determine the prevalence of vitamin D deficiency among psychiatric inpatients in a large North American city. The association of vitamin D status with clinical characteristics was also explored, and subgroups of patients that are more vulnerable to vitamin D deficiency were identified. METHOD: This descriptive study looked at 107 unselected consecutive admissions to a psychiatric inpatient service in New York City between September and early December 2010...
2012: Primary Care Companion to CNS Disorders
David B Menkes, Kaye Lancaster, Michael Grant, Reginald W Marsh, Peter Dean, Stephen A du Toit
BACKGROUND: Vitamin D deficiency is widespread in New Zealand, confers multiple health risks, and may be particularly common among people with psychiatric illness. We studied vitamin D status in an unselected sample of adult psychiatric inpatients in Hamilton (latitude 37.5 S) during late winter. METHODS: We recruited 102 consenting subjects and measured 25-hydroxy vitamin D3 levels in venous blood using a competitive electrochemiluminescence immunoassay. In addition to descriptive statistics, we used one-sample t-tests to determine the extent to which ethnic and diagnostic subgroups fell below the vitamin D deficiency threshold of 50 nM...
2012: BMC Psychiatry
Dganit Itzhaky, Daniela Amital, Katya Gorden, Alisa Bogomolni, Yoav Arnson, Howard Amital
BACKGROUND: Vitamin D is increasingly associated with the pathology of cognition and mental illness. Vitamin D receptors have been detected on neurons that regulate behavior. OBJECTIVE: To assess vitamin D serum concentrations in patients with major depression and schizophrenia as compared to healthy controls and to determine if a correlation exists between serum levels of vitamin D and disease activity. METHODS: We recruited 50 patients with schizophrenia and compared them to 33 patients with major depression and 50 controls with no major psychopathology...
February 2012: Israel Medical Association Journal: IMAJ
Anwar K Abdullah, Salman Khan, Shaheen F Mustafa, Abu A Qutubuddin, Charles M Davis
OBJECTIVE: Low vitamin D levels are common in psychiatric patients, but a need for vitamin D supplementation in these individuals remains controversial. Low vitamin D levels are reportedly associated with high prevalence of cardiometabolic risk factors, and both are common in psychiatric patients, but the relationship between diagnosis and severity of illness and cardiometabolic risk status and the effect of vitamin D treatment on them is not known. We studied these relationships and effect of vitamin D(3) treatment on them in 290 long-term psychiatric inpatients...
2012: Primary Care Companion to CNS Disorders
Hiroko Watanabe, Sadayo Ishida, Yoshie Konno, Momoyo Matsumoto, Shinobu Nomachi, Kiyoko Masaki, Hisayo Okayama, Yasushi Nagai
INTRODUCTION: Folate deficiencies may be linked to depressive disorders among persons suffering from neurological and psychiatric problems. The purpose of the present study was to evaluate the impact of dietary folate intake on depressive symptoms in young Japanese women of reproductive age. METHODS: The study was conducted in Japan in 2009 with 141 Japanese women aged 18 to 28 years. A Japanese version of the Center for Epidemiologic Studies Depression (CES-D) scale was used to screen for depressive symptoms...
January 2012: Journal of Midwifery & Women's Health
D Jeffrey Newport, Shuang Ji, Qi Long, Bettina T Knight, Elizabeth B Zach, Elizabeth N Smith, Natalie J Morris, Zachary N Stowe
OBJECTIVE: To examine the association between severity of maternal depression and anxiety during pregnancy and the maternal use of medicinal agents and habit-forming substances. METHOD: Participants in a prospective study of prenatal DSM-IV depressive and anxiety disorders at the Emory Women's Mental Health Program who completed weekly documentation of prenatal drug exposure and ≥ 3 administrations of the Hamilton Depression Rating Scale (HDRS) or Hamilton Anxiety Rating Scale (HARS) were included...
February 2012: Journal of Clinical Psychiatry
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