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Vitamin D in psychiatric illness

Dipen Patel, Manjunath Minajagi
Aims and methodVitamin D deficiency is increasing in the general population, and is linked with physical and mental illness. However, evidence on its prevalence in people with mental illness is limited. This study investigated vitamin D deficiency in 104 adult patients admitted to a psychiatric hospital in the UK. RESULTS: Forty-nine per cent were vitamin D deficient (serum 25(OH)D 50 nmol/L). There were no statistically significant differences in mean serum vitamin D between different subgroups of mental illness...
June 2018: BJPsych Bulletin
Robert Freedman, Sharon K Hunter, M Camille Hoffman
Genes, infection, malnutrition, and other factors affecting fetal brain development are a major component of risk for a child's emotional development and later mental illnesses, including schizophrenia, bipolar disorder, and autism. Prenatal interventions to ameliorate that risk have yet to be established for clinical use. A systematic review of prenatal nutrients and childhood emotional development and later mental illness was performed. Randomized trials of folic acid, phosphatidylcholine, and omega-3 fatty acid supplements assess effects of doses beyond those adequate to remedy deficiencies to promote normal fetal development despite genetic and environmental risks...
March 21, 2018: American Journal of Psychiatry
Paul P Lerner, Laura Sharony, Chanoch Miodownik
BACKGROUND & AIMS: Vitamin D deficiency has been identified as a global problem. Approximately 14% of the world population has inadequate vitamin D levels. This vitamin has been usually associated with bone disorders such as rickets, osteomalacia, and osteoporosis. However, these disorders present only a small part of all the disturbances which can be induced by its deficiency. Low serum vitamin D is associated with development of cardiovascular diseases, hypertension, neurodegenerative diseases, diabetes mellitus, metabolic syndrome and even cancer...
February 2018: Clinical Nutrition ESPEN
Joseph Firth, Rebekah Carney, Brendon Stubbs, Scott B Teasdale, Davy Vancampfort, Philip B Ward, Michael Berk, Jerome Sarris
Objective: Diet is increasingly recognized as a potentially modifiable factor influencing the onset and outcomes of psychiatric disorders. Whereas, previous research has shown long-term schizophrenia is associated with various nutritional deficiencies, this meta-analysis aimed to determine the prevalence and extent of nutritional deficits in first-episode psychosis (FEP). Method: A search of electronic databases conducted in July 2017 identified 28 eligible studies, examining blood levels of 6 vitamins and 10 minerals across 2612 individuals: 1221 individuals with FEP and 1391 control subjects...
November 30, 2017: Schizophrenia Bulletin
Ivana Goluza, Jay Borchard, Nalin Wijesinghe, Kishan Wijesinghe, Nagesh Pai
OBJECTIVES: The objective of the current study was to examine the pathology test utilisation of 25-hydroxyvitamin D (25(OH)D) within an Australian inpatient psychiatric setting. METHOD: A retrospective audit of 300 random hospital files of those admitted as inpatients between Nov 2014 and Nov 2015 was undertaken. Data was quantitatively analysed and described. RESULTS: The number of inpatients who had a vitamin D determination during their admission was 37/300 (12...
February 2018: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
Svetlana Ristic, Sandra Zivanovic, Dragan R Milovanovic, Vladimir Janjic, Danijela Djokovic, Ana Jovicevic, Marijana Stanojevic Pirkovic, Sanja Kocic
This research aimed to investigate factors associated with vitamin D deficiency and to provide data about its prevalence in patients suffering from different psychiatric illnesses. The study had a cross-sectional design and it included 220 patients of both genders, aged from 19-81 y, with a wide range of mental disorders (F00-F89), and treated in routine ambulatory and hospital practice. The researchers collected data from three sources: medical records, a study questionnaire and biochemical analysis of patients' serum samples (concentration of vitamin D measured as 25(OH)D, calcium, phosphorus, magnesium, sodium and potassium)...
2017: Journal of Nutritional Science and Vitaminology
Alessandra N Bazzano, Lisa Littrell, Stephen Lambert, Cody Roi
BACKGROUND: Recent evidence has indicated a potential role of vitamin D3 in a range of neuropsychiatric outcomes, as well as on cognitive function, but conflicting data have left that role uncertain. Understanding potential associations of vitamin D status with psychiatric illness will allow clinicians to better assess therapeutic options. Few studies have examined vitamin D status among a racially diverse group of psychiatric patients who have been hospitalized, and none has done so in the southern US where socioeconomic inequality is high...
2016: Neuropsychiatric Disease and Treatment
Stephanie Fryar-Williams
The Mental Health Biomarker Project (2010-2016) explored variables for psychosis in schizophrenia and schizoaffective disorder. Blood samples from 67, highly characterized symptomatic cases and 67 gender and age matched control participants were analyzed for methyl tetrahydrofolate reductase (MTHFR) 677C → T gene variants and for vitamin B6, B12 and D, folate, unbound copper, zinc cofactors for enzymes in the methylation cycle, and related catecholamine pathways. Urine samples were analyzed for indole-catecholamines, their metabolites, and oxidative-stress marker, hydroxylpyrolline-2-one (HPL)...
2016: Frontiers in Psychiatry
Lakshminarayana Chekuri, Purushottam B Thapa, Carolyn L Turturro, Dinesh Mittal, Erick Messias
OBJECTIVE: To describe the prevalence of vitamin D deficiency in psychiatric inpatients with serious mental illness. Associated clinical and sociodemographic factors are also explored. METHOD: Data were collected using a retrospective review of medical records. Eligible subjects were individuals aged ≥ 18 years who were consecutively newly admitted to an adult inpatient teaching unit of a state psychiatric hospital from July 2012 through August 2013. The main outcome measure was prevalence rate of vitamin D deficiency in the target population...
2015: Primary Care Companion to CNS Disorders
Qiang Zeng, Timothy Dellenbaugh, Martin Maldonado, Joseph Moon, Rob Hornstra
BACKGROUND: Vitamin D deficiency is a re-emerging epidemic in North America. It is increasingly linked to the pathology of cognition and mental illness and is also common in psychiatric patients. AIMS: This study was designed to determine the prevalence of vitamin D deficiency among psychiatric inpatients in Kansas City, to explore the association between vitamin D status and clinical characteristics, and to identify the association of medical problems related to vitamin D deficiency in mental illness...
2016: Nordic Journal of Psychiatry
Raoul Belzeaux, Laurent Boyer, El Chérif Ibrahim, François Féron, Marion Leboyer, Guillaume Fond
Patients with psychiatric disorders display high levels of hypovitaminosis D (<50nmol/L). It remains unclear whether it is associated with specific diagnoses. To further explore vitamin D status in psychiatric inpatients, 82 individuals with mood disorders or schizophrenia/schizoaffective disorders were included. Hypovitaminosis D was significantly lower in patients with mood disorders than patients with schizophrenia (standardized β coefficient=0.385, p=0.007). Further studies are warranted to determine specific causes of hypovitaminosis D and the interest of supplementation...
September 30, 2015: Psychiatry Research
Najla J Alhraiwil, Anna Ali, Mowafa S Househ, Ali M Al-Shehri, Ashraf A El-Metwally
OBJECTIVE: To assess the epidemiology of attention deficit hyperactivity disorder (ADHD) in Arab countries, and identify gaps for future research. METHODS: We searched PubMed from July 1978 to July 2014 and reviewed local journals with cross-referencing. The keywords we used were ADHD, diagnosis, prevalence, incidence, factor, diagnosis, rate, risk, and each of the names of the 22 Arab countries (Jordan, Egypt, Lebanon, Saudi Arabia, and so on). Studies were eligible for inclusion if they investigated the epidemiology of ADHD in any Arab country, and were published in English...
April 2015: Neurosciences: the Official Journal of the Pan Arab Union of Neurological Sciences
Uté Vollmer-Conna, Erin Cvejic, Isabelle Granville Smith, Dusan Hadzi-Pavlovic, Gordon Parker
Depression in the context of acute coronary syndrome (ACS) is understood to confer increased morbidity and mortality risk. The pathophysiological mechanisms underlying this association remain poorly understood, although several candidates including inflammation, cardiac autonomic dysregulation, and behavioural factors are viewed as of key importance. No single bio-behavioural explanatory model of ACS-associated depression has emerged, likely due the substantial heterogeneity across both conditions. We studied 344 patients with ACS; 45 fulfilled diagnostic (DSM-IV) criteria for a major depressive episode occurring within 1-month of ACS, and 13 had ongoing major depression that pre-dated ACS and continued through to 1 month post-ACS...
August 2015: Brain, Behavior, and Immunity
N B Lundin, M J Niciu, D A Luckenbaugh, D F Ionescu, E M Richards, J L Vande Voort, N E Brutsche, R Machado-Vieira, C A Zarate
INTRODUCTION: Deficiencies in both vitamin B12 and folate have been associated with depression. Recently, higher baseline vitamin B12 levels were observed in individuals with bipolar depression who responded to the antidepressant ketamine at 7 days post-infusion. This study sought to -replicate this result by correlating peripheral vitamin levels with ketamine's antidepressant efficacy in bipolar depression and major depressive disorder (MDD). METHODS: Baseline vitamin B12 and folate levels were obtained in 49 inpatients with treatment-resistant MDD and 34 inpatients with treatment-resistant bipolar depression currently experiencing a major depressive episode...
July 2014: Pharmacopsychiatry
Julia J Rucklidge, Jeanette Johnstone, Brigette Gorman, Anna Boggis, Christopher M Frampton
BACKGROUND: To date there has been no research investigating moderators of response to micronutrient treatment of mental illness, specifically baseline nutrient levels. METHOD: We conducted analyses of data from a randomized placebo-controlled trial (RCT) of 80 adults (≥16years) with Attention-Deficit/Hyperactivity Disorder (ADHD), whereby participants were treated acutely (8weeks) with micronutrients or placebo followed by an open-label (OL) phase of 8weeks whereby all participants received micronutrients...
April 3, 2014: Progress in Neuro-psychopharmacology & Biological Psychiatry
Matthieu Crews, John Lally, Poonam Gardner-Sood, Oliver Howes, Stefania Bonaccorso, Shubulade Smith, Robin M Murray, Marta Di Forti, Fiona Gaughran
BACKGROUND: Vitamin D deficiency is seen in a high proportion of people with established psychotic disorders, but it is not known if this is present at onset of the illness. We set out to examine vitamin D levels in people with their first episode of psychosis (FEP). METHOD: We conducted a matched case-control study to examine vitamin D levels and rates of vitamin D deficiency in sixty nine patients presenting with their FEP and sixty nine controls matched for age, sex and ethnicity...
November 2013: Schizophrenia Research
Martino Belvederi Murri, Matteo Respino, Mattia Masotti, Marco Innamorati, Valeria Mondelli, Carmine Pariante, Mario Amore
Individuals with psychotic disorders are more likely to have vitamin D (VD) deficiency, while evidence suggests VD could have pathophysiological roles. We summarized meta-analytically the available evidence on VD levels in psychotic disorders in comparison with healthy controls and other psychiatric illnesses. We found seven studies, all reporting insufficient VD levels in patients with psychosis. Schizophrenia had a medium effect size for lower VD than healthy controls, and a trend for lower levels than other psychoses...
October 2013: Schizophrenia Research
Melanie Rylander, Steven Verhulst
OBJECTIVE: The extraskeletal effects of vitamin D have gained increasing attention with the discovery of receptors in a variety of organ systems. Previous work has identified associations between vitamin D insufficiency and a variety of mental illnesses, including affective, cognitive, and psychotic spectrum disorders. We attempted to determine the point prevalence of vitamin D insufficiency among psychiatric inpatients and determine if there was a relationship between vitamin D insufficiency and specific diagnoses and pharmacological treatments...
July 2013: Journal of Psychiatric Practice
Laura Kevere, Santa Purvina, Daiga Bauze, Marcis Zeibarts, Raisa Andrezina, Linda Piekuse, Edgars Brekis, Indulis Purvins
BACKGROUND: High level of homocysteine (Hcy) is risk factor of schizophrenia and mood disorders. AIM: The aim was to detect a serum level of Hcy, examine the associations between the level of Hcy, methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism and clinical properties for patients with schizophrenia, mood disorders and in a control group. MATERIAL AND METHODS: There were 88 patients with schizophrenia, 28 with affective disorders and 94 from the control group...
February 2014: Nordic Journal of Psychiatry
N A Bokhan, A F Abolonin, I É Ankudinova, D I Kurgak, A I Mandel'
AIM: To evaluate the efficacy of Remaxol used to treat post-withdrawal disorders in alcoholic patients with comorbid liver damage. SUBJECTS AND METHODS: The authors assessed the severity of clinical parameters, such as pathological craving and anhedonia, biochemical parameters (bilirubin, alanine aminotransferase (ALT), and aspartate aminotransferase (AST)) in 120 patients aged 30-60 years in the stage of remission formation. The patients were divided into two groups: 1) 62 patients received Remaxol; 2) 58 persons took placebo (a comparative group)...
2012: Terapevticheskiĭ Arkhiv
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