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Omega 3 in psychiatric illness

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https://www.readbyqxmd.com/read/26952820/long-chain-omega-3-polyunsaturated-fatty-acids-in-the-treatment-of-psychiatric-illnesses-in-children-and-adolescents
#1
Edward H Clayton, Tanya L Hanstock, Manohar L Garg, Philip L Hazell
OBJECTIVE: Long chain omega-3 polyunsaturated fatty acids (LCn-3PUFA) are in increasing use in the general population to treat health problems. The objective of the current article is to review the evidence for the rationale and benefit of LCn-3PUFA in the treatment of common psychiatric disorders in children and adolescents. METHODS: A search of Psychlit, PubMed and Cochrane Databases was conducted using the terms child, adolescent, bipolar, depression, psychosis, first-episode psychosis, schizophrenia, attention deficit hyperactivity disorder (ADHD), autism, psychiatric, omega-3, n-3, docosahexaenoic acid and eicosapentaenoic acid...
April 2007: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/26860589/detection-and-treatment-of-omega-3-fatty-acid-deficiency-in-psychiatric-practice-rationale-and-implementation
#2
Erik Messamore, Robert K McNamara
A body of translational evidence has implicated dietary deficiency in long-chain omega-3 (LCn-3) fatty acids, including eicosapenaenoic acid (EPA) and docosahexaenoic acid (DHA), in the pathophysiology and potentially etiology of different psychiatric disorders. Case-control studies have consistently observed low erythrocyte (red blood cell) EPA and/or DHA levels in patients with major depressive disorder, bipolar disorder, schizophrenia, and attention deficit hyperactivity disorder. Low erythrocyte EPA + DHA biostatus can be treated with fish oil-based formulations containing preformed EPA + DHA, and extant evidence suggests that fish oil supplementation is safe and well-tolerated and may have therapeutic benefits...
2016: Lipids in Health and Disease
https://www.readbyqxmd.com/read/26650554/-attenuated-psychosis-syndrome-a-literature-review
#3
REVIEW
Alejandro Szmulewicz, José M Smith, Marina P Valerio
Despite recent findings on the treatment of schizophrenia, it is an illness still associated with high morbidity and incapacity in social and work domains. There is a growing interest in examining the phases prior to the development of the illness so as to make early interventions that would potentially change its devastating course. The attenuated psychosis syndrome was included in the section III of the last version of the Diagnostic and Statistical Manual of Mental Disorders as a condition in which a patient exhibits mild psychotic symptoms, an intact reality testing and certain degree of social or occupational impairment...
May 2015: Vertex: Revista Argentina de Psiquiatriá
https://www.readbyqxmd.com/read/26646031/a-randomized-clinical-trial-of-high-eicosapentaenoic-acid-omega-3-fatty-acids-and-inositol-as-monotherapy-and-in-combination-in-the-treatment-of-pediatric-bipolar-spectrum-disorders-a-pilot-study
#4
RANDOMIZED CONTROLLED TRIAL
Janet Wozniak, Stephen V Faraone, James Chan, Laura Tarko, Mariely Hernandez, Jacqueline Davis, K Yvonne Woodworth, Joseph Biederman
OBJECTIVE: We conducted a 12-week, randomized, double-blind, controlled clinical trial to evaluate the effectiveness and tolerability of high eicosapentaenoic acid (EPA)/docosahexaenoic acid (DHA) omega-3 fatty acids and inositol as monotherapy and in combination in children with bipolar spectrum disorders. METHOD: Participants were children 5-12 years of age meeting DSM-IV diagnostic criteria for bipolar spectrum disorders (bipolar I or II disorder or bipolar disorder not otherwise specified [NOS]) and displaying mixed, manic, or hypomanic symptoms...
November 2015: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/26400434/the-role-of-omega-3-fatty-acids-in-diets
#5
C Gomez-Candela, M C Roldan Puchalt, S Palma Milla, B Lopez Plaza, L Bermejo
The article is a summary of Dra. Carmen Gómez Candela's presentation at the Science in Nutrition 3rd International Congress in Milan, March 2014. The article covers omega-3 fatty acids use in different medical areas and several institutions' opinions in relation to the topic. Omega-3 acids are essential fatty acids. A certain amount of omega-3 is needed in our daily diet; however, the usual consumption is generally less than the recommended amount. Changes in dietary patterns in the course of history have led to deficit levels of omega-3 in the human body...
2015: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/25880383/early-psychotic-experiences-interventions-problems-and-perspectives
#6
REVIEW
S Dimitrakopoulos, C Kollias, N C Stefanis, V Kontaxakis
Psychotic or psychotic-like experiences and symptoms may precede and be indicative of later psychosis emergence. DSM-5 has introduced Attenuated Psychosis Syndrome (APS) as a condition for further study, arguing for its clinical validity and the need for identifying sub- threshold psychotic states. Early psychosis intervention has an already established role in reducing the Duration of Untreated Psychosis (DUP), delaying psychosis onset and relieving Ultra High Risk (UHR) individuals from their presenting symptoms...
January 2015: Psychiatrikē, Psychiatriki
https://www.readbyqxmd.com/read/25770081/characterising-acute-coronary-syndrome-associated-depression-let-the-data-speak
#7
Uté Vollmer-Conna, Erin Cvejic, Isabelle Granville Smith, Dusan Hadzi-Pavlovic, Gordon Parker
Depression in the context of acute coronary syndrome (ACS) is understood to confer increased morbidity and mortality risk. The pathophysiological mechanisms underlying this association remain poorly understood, although several candidates including inflammation, cardiac autonomic dysregulation, and behavioural factors are viewed as of key importance. No single bio-behavioural explanatory model of ACS-associated depression has emerged, likely due the substantial heterogeneity across both conditions. We studied 344 patients with ACS; 45 fulfilled diagnostic (DSM-IV) criteria for a major depressive episode occurring within 1-month of ACS, and 13 had ongoing major depression that pre-dated ACS and continued through to 1 month post-ACS...
August 2015: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/25640673/cognition-as-a-target-in-major-depression-new-developments
#8
REVIEW
Brisa Solé, Esther Jiménez, Anabel Martinez-Aran, Eduard Vieta
Major depressive disorder (MDD) is a highly prevalent and disabling psychiatric illness often accompanied of cognitive dysfunction which may persist even when patients achieve clinical remission. Currently, cognitive deficits emerge as a potential target because they compromise the functional outcome of depressed patients. The aim of this study was to review data for several potential pharmacological treatments targeting cognition in MDD, resulting from monotherapy or adjunctive treatment. An extensive and systematic Pubmed/Medline search of the published literature until March 2014 was conducted using a variety of search term to find relevant articles...
February 2015: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/25373095/the-potential-for-military-diets-to-reduce-depression-suicide-and-impulsive-aggression-a-review-of-current-evidence-for-omega-3-and-omega-6-fatty-acids
#9
REVIEW
Joseph R Hibbeln, Rachel V Gow
The current burden of psychological distress and illness poses as a significant barrier to optimal force efficacy. Here we assess nutrients in military diets, specifically highly unsaturated essential fatty acids, in the reduction of risk or treatment of psychiatric distress. Moderate to strong evidence from several meta-analyses of prospective cohort trials indicate that Mediterranean diet patterns reduce risk of clinical depressions. Specific nutrients and foods of biological interest in relation to mental health outcomes are then discussed and evaluated...
November 2014: Military Medicine
https://www.readbyqxmd.com/read/25120120/-the-role-of-families-in-the-quebec-mental-health-system
#10
Jean-Pierre Bonin, Gabrielle Chicoine, Hélène Fradet, Caroline Larue, Hélène Racine, Marie-Claude Jacques, Denise St-Cyr Tribble
Purpose. This paper aims to summarize the current situation regarding the role of families of persons with mental disorders within the mental health system in Quebec.Methods. We made a research in the most recent and pertinent papers or books regarding: 1) the history of the family involvement in the mental health system in Quebec; 2) the present situation of these families and the models that we can see and 3) identify in recent governmental or research documents recommendations regarding a greater empowerment of the families in the mental health system...
2014: Santé Mentale Au Québec
https://www.readbyqxmd.com/read/24953860/dietary-intake-and-plasma-metabolomic-analysis-of-polyunsaturated-fatty-acids-in-bipolar-subjects-reveal-dysregulation-of-linoleic-acid-metabolism
#11
Simon J Evans, Rachel N Ringrose, Gloria J Harrington, Peter Mancuso, Charles F Burant, Melvin G McInnis
Polyunsaturated fatty acids (PUFA) profiles associate with risk for mood disorders. This poses the hypothesis of metabolic differences between patients and unaffected healthy controls that relate to the primary illness or are secondary to medication use or dietary intake. However, dietary manipulation or supplementation studies show equivocal results improving mental health outcomes. This study investigates dietary patterns and metabolic profiles relevant to PUFA metabolism, in bipolar I individuals compared to non-psychiatric controls...
October 2014: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/24844177/genetic-risk-prediction-and-neurobiological-understanding-of-alcoholism
#12
D F Levey, H Le-Niculescu, J Frank, M Ayalew, N Jain, B Kirlin, R Learman, E Winiger, Z Rodd, A Shekhar, N Schork, F Kiefer, F Kiefe, N Wodarz, B Müller-Myhsok, N Dahmen, M Nöthen, R Sherva, L Farrer, A H Smith, H R Kranzler, M Rietschel, J Gelernter, A B Niculescu
We have used a translational Convergent Functional Genomics (CFG) approach to discover genes involved in alcoholism, by gene-level integration of genome-wide association study (GWAS) data from a German alcohol dependence cohort with other genetic and gene expression data, from human and animal model studies, similar to our previous work in bipolar disorder and schizophrenia. A panel of all the nominally significant P-value SNPs in the top candidate genes discovered by CFG  (n=135 genes, 713 SNPs) was used to generate a genetic  risk prediction score (GRPS), which showed a trend towards significance (P=0...
2014: Translational Psychiatry
https://www.readbyqxmd.com/read/24345766/coupling-energy-homeostasis-with-a-mechanism-to-support-plasticity-in-brain-trauma
#13
Rahul Agrawal, Ethika Tyagi, Laurent Vergnes, Karen Reue, Fernando Gomez-Pinilla
Metabolic dysfunction occurring after traumatic brain injury (TBI) is an important risk factor for the development of psychiatric illness. In the present study, we utilized an omega-3 diet during early life as a metabolic preconditioning to alter the course of TBI during adulthood. TBI animals under omega-3 deficiency were more prone to alterations in energy homeostasis (adenosine monophosphate-activated protein kinase; AMPK phosphorylation and cytochrome C oxidase II; COII levels) and mitochondrial biogenesis (peroxisome proliferator-activated receptor gamma coactivator 1-alpha; PGC-1α and mitochondrial transcription factor A; TFAM)...
April 2014: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/23945449/positive-affect-and-survival-in-patients-with-stable-coronary-heart-disease-findings-from-the-heart-and-soul-study
#14
Petra W Hoen, Johan Denollet, Peter de Jonge, Mary A Whooley
OBJECTIVE: Positive affect can improve survival, but the mechanisms responsible for this association are unknown. We sought to evaluate the association between positive affect and mortality in patients with stable coronary heart disease and to determine biological and behavioral factors that might explain this association. METHOD: The Heart and Soul Study is a prospective cohort study of 1,018 outpatients with stable coronary heart disease. Participants were recruited between September 11, 2000, and December 20, 2002, and were followed up to June 2011...
July 2013: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/23866813/a-randomized-controlled-trial-investigating-the-effects-of-pcso-524-a-patented-oil-extract-of-the-new-zealand-green-lipped-mussel-perna-canaliculus-on-the-behaviour-mood-cognition-and-neurophysiology-of-children-and-adolescents-aged-6-14-years-experiencing
#15
RANDOMIZED CONTROLLED TRIAL
James D Kean, David Camfield, Jerome Sarris, Marni Kras, Richard Silberstein, Andrew Scholey, Con Stough
BACKGROUND: The prevalence rate of attention-deficit/hyperactivity disorder (ADHD) within Western cultures is between 5% and 12%, and is the most common psychiatric illness among school-aged children, with an estimated 50% of these children retaining ADHD symptoms for the rest of their lives. Children with ADHD have lower blood levels of long-chain Poly Unsaturated Fatty Acids (LC PUFAs) compared with children without ADHD, and following PUFA supplementation, have shown improvements in ADHD-related symptoms...
2013: Nutrition Journal
https://www.readbyqxmd.com/read/23483949/vulnerability-imposed-by-diet-and-brain-trauma-for-anxiety-like-phenotype-implications-for-post-traumatic-stress-disorders
#16
Ethika Tyagi, Rahul Agrawal, Yumei Zhuang, Catalina Abad, James A Waschek, Fernando Gomez-Pinilla
Mild traumatic brain injury (mTBI, cerebral concussion) is a risk factor for the development of psychiatric illness such as posttraumatic stress disorder (PTSD). We sought to evaluate how omega-3 fatty acids during brain maturation can influence challenges incurred during adulthood (transitioning to unhealthy diet and mTBI) and predispose the brain to a PTSD-like pathobiology. Rats exposed to diets enriched or deficient in omega-3 fatty acids (n-3) during their brain maturation period, were transitioned to a western diet (WD) when becoming adult and then subjected to mTBI...
2013: PloS One
https://www.readbyqxmd.com/read/22585900/-n-3-fatty-acids-molecular-role-and-clinical-uses-in-psychiatric-disorders
#17
REVIEW
Pedro Luis Prior, José Carlos Fernandes Galduróz
New discoveries in the field of neurophysiology and neuropharmacology have revealed the role of (n-3) fatty acids in controlling inflammation and protecting neuron cells from oxidative damage, preserving their function. It has also been thought that their psychoactive properties could be beneficial in certain psychiatric illnesses. This article discusses the newest discoveries of the affected activities by these fats in the cerebral cortex and the efforts that have been made to put them in practice in clinical trials in humans...
May 2012: Advances in Nutrition
https://www.readbyqxmd.com/read/22472025/nutraceuticals-in-psychiatric-practice
#18
REVIEW
Matteo Chiappedi, Silvia de Vincenzi, Maurizio Bejor
Nutraceuticals can be defined as food components or active principles present in aliments which have positive effects for health and quality of life, including preventing or treating disorders. Herbal and "natural" food supplements are increasingly used to treat different psychiatric disorders, often as "self-prescribed" therapies. With factors such as chronic illness, poor health, emotional distress, and quality of life influencing the desire for complementary medicine, patients with comorbid medical and psychiatric problems seem likely to turn to this approach...
August 2012: Recent Patents on CNS Drug Discovery
https://www.readbyqxmd.com/read/21940602/the-use-of-omega-3-fatty-acids-in-mental-illness
#19
REVIEW
Jessica L Gören, Ashley T Tewksbury
PURPOSE: This article will summarize the current evidence on the effects of omega-3 fatty acids on prevention and treatment of mental illness. BACKGROUND: Omega-3 fatty acids are involved in many physiologic processes. Since they cannot be made de novo in the body, they are considered essential nutrients. As the Western diet evolved, dietary intake of fatty acids has shifted to increased omega-6 fatty acids and decreased omega-3 fatty acids intake. These changes have been correlated with numerous differences in prevalence and course of mental illnesses...
October 2011: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/21838664/randomized-placebo-controlled-trials-of-omega-3-polyunsaturated-fatty-acids-in-psychiatric-disorders-a-review-of-the-current-literature
#20
REVIEW
Pierluigi Politi, Matteo Rocchetti, Enzo Emanuele, Mariangela Rondanelli, Francesco Barale
A growing body of evidence suggests that omega (ω)-3 polyunsaturated fatty acids (PUFAs) are clinically useful in patients with psychiatric disorders. In the present review, we summarize the findings of randomized, placebo-controlled clinical trials that have focused on the potential therapeutic utility of ω-3 PUFAs in patients with mental illnesses. We searched the PubMed database for placebo-controlled clinical trials using the keywords "PUFAs", "omega-3", "eicosapentaenoic acid", and "docosahexaenoic acid" in combination with the following terms: "anxiety disorders", "mood disorders", "autism", "attention-deficit hyperactivity disorder" (ADHD), "personality disorders", and "schizophrenia"...
September 2013: Current Drug Discovery Technologies
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