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https://www.readbyqxmd.com/read/27878625/reference-ranges-of-fetal-cardiac-biometric-parameters-using-three-dimensional-ultrasound-with-spatiotemporal-image-correlation-m%C3%A2-mode-and-their-applicability-in-congenital-heart-diseases
#1
Giselle Darahem Tedesco, Marilim de Souza Bezerra, Fernanda Silveira Bello Barros, Wellington P Martins, Luciano Marcondes Machado Nardozza, Milene Carvalho Carrilho, Antonio Fernandes Moron, Francisco Herlânio Costa Carvalho, Liliam Cristine Rolo, Edward Araujo Júnior
To determine reference values for fetal heart biometric parameters using the spatiotemporal image correlation (STIC) M mode and their applicability in congenital heart diseases (CHDs). A cross-sectional prospective study was conducted with 300 singleton pregnancies between 20 and 33 + 6 weeks of gestation. Right ventricular wall thickness (RVWT), interventricular septum thickness (IVST), and left ventricular wall thickness (LVWT) were measured off-line using the STIC-M mode with the cursor perpendicular to the interventricular septum...
November 23, 2016: Pediatric Cardiology
https://www.readbyqxmd.com/read/27869446/-oncopathological-aspects-of-brca1-and-brca2-genes-inactivation-in-tumors-of-ovary-fallopian-tube-and-pelvic-peritoneum
#2
Petr Škapa, Pavel Dundr
Ovarian carcinoma represents a heterogeneous group of malignant epithelial tumors which could be divided into two fundamental groups: Type I (endometrioid carcinoma, clear cell carcinoma, low grade serous carcinoma, mucinous carcinoma and more rare seromucinous carcinoma and malignant Brenner tumor) and type II (high grade serous carcinoma - HGSC). HGSC is the most frequent ovarian carcinoma which may be etiologically linked to inactivation of tumor suppressor genes BRCA1/2 and TP53 and differs from type I carcinomas by higher aggressiveness, tendency to peritoneal spread and worse prognosis...
2016: Ceskoslovenská Patologie
https://www.readbyqxmd.com/read/27856443/genomics-of-ovarian-cancer-progression-reveals-diverse-metastatic-trajectories-including-intraepithelial-metastasis-to-the-fallopian-tube
#3
Mark A Eckert, Shawn Pan, Kyle M Hernandez, Rachel M Loth, Jorge Andrade, Samuel L Volchenboum, Pieter Faber, Anthony Montag, Ricardo Lastra, Marcus E Peter, S Diane Yamada, Ernst Lengyel
: Accumulating evidence has supported the fallopian tube rather than the ovary as the origin for high-grade serous ovarian cancer (HGSOC). To understand the relationship between putative precursor lesions and metastatic tumors, we performed whole-exome sequencing on specimens from eight HGSOC patient progression series consisting of serous tubal intraepithelial carcinomas (STIC), invasive fallopian tube lesions, invasive ovarian lesions, and omental metastases. Integration of copy number and somatic mutations revealed patient-specific patterns with similar mutational signatures and copy-number variation profiles across all anatomic sites, suggesting that genomic instability is an early event in HGSOC...
October 7, 2016: Cancer Discovery
https://www.readbyqxmd.com/read/27776011/uterine-serous-carcinomas-frequently-metastasize-to-the-fallopian-tube-and-can-mimic-serous-tubal-intraepithelial-carcinoma
#4
Friedrich Kommoss, Asma Faruqi, C Blake Gilks, Sarah Lamshang Leen, Naveena Singh, Nafisa Wilkinson, W Glenn McCluggage
We investigated the frequency, histopathologic, and immunohistochemical characteristics of tubal involvement in uterine serous carcinoma (USC) and aimed to clarify the relationship between "serous tubal intraepithelial carcinoma (STIC)" and USC in these cases. Cases of USC with complete tubal examination were prospectively collected and reviewed for the presence of tubal involvement. Immunohistochemical analysis for p53 and WT1 was performed on the endometrial and tubal tumor in cases with tubal involvement...
October 21, 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27772617/stic-ing-with-what-we-know
#5
Lee-May Chen
No abstract text is available yet for this article.
November 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27733814/cytologic-studies-of-the-fallopian-tube-in-patients-undergoing-salpingo-oophorectomy
#6
Hao Chen, Robert Klein, Stacy Arnold, Setsuko Chambers, Wenxin Zheng
BACKGROUND: Mounting evidence suggests the fallopian tube as the origin for ovarian high grade serous carcinoma (HGSC). We attempted to identify the tubal cytological features that allow us to distinguish malignant from benign conditions. METHODS: Tubal specimens (n = 56) were collected from patients who underwent bilateral salpingo-oophorectomy (BSO) due to various clinical indications. A standard procedure to collect fallopian tube brushings from freshly received surgical specimens was developed...
2016: Cancer Cell International
https://www.readbyqxmd.com/read/27732120/serous-tubal-intraepithelial-carcinoma-stic-clinical-impact-and-management
#7
Vit Weinberger, Marketa Bednarikova, David Cibula, Michal Zikan
Introduction Serous tubal intraepithelial carcinoma (STIC) is most likely precursor lesion of the most part of high-grade serous pelvis carcinomas, carcinosarcoma and undifferentiated carcinoma with incidence of 0.6% to 7% in BRCA carriers or women with strong family history of breast or ovarian carcinoma. STIC is a pathomorphologically and immunohistochemically detectable lesion which biological significance and clinical relevance is unknown. Areas covered We investigate methods of STIC diagnostics and we present an overview of recent studies and available knowledge on surgical management, adjuvant chemotherapy and subsequent follow-up procedure in women with an isolated STIC...
October 12, 2016: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/27721278/secretory-cell-outgrowths-p53-signatures-and-serous-tubal-intraepithelial-carcinoma-in-the-fallopian-tubes-of-patients-with-sporadic-pelvic-serous-carcinoma
#8
Neha Mittal, Radhika Srinivasan, Nalini Gupta, Arvind Rajwanshi, Raje Nijhawan, Upasana Gautam, Swati Sood, Lakhbir Dhaliwal
CONTEXT: High-grade serous carcinomas of ovarian, tubal, and peritoneal origin are together referred as pelvic serous carcinoma. The fallopian tubes, ovarian surface epithelium, and the tuboperitoneal junctional epithelium are all implicated in pelvic serous carcinogenesis. AIMS: The aim of this study is to identify putative precursor lesions of serous carcinoma including secretory cell outgrowths (SCOUTs), serous tubal intraepithelial carcinoma (STIC), and p53 signatures and assign its probable site of origin...
October 2016: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/27713911/weaponizing-human-egf-containing-fibulin-like-extracellular-matrix-protein-1-efemp1-for-21-st-century-cancer-therapeutics
#9
Yi-Hong Zhou, Yuanjie Hu, Liping Yu, Chao Ke, Christopher Vo, Hao Hsu, Zhenzhi Li, Anne T Di Donato, Abhishek Chaturbedi, Ji Won Hwang, Eric R Siegel, Mark E Linskey
De-regulated EFEMP1 gene expression in solid tumors has been widely reported with conflicting roles. We dissected EFEMP1 to identify domains responsible for its cell context-dependent dual functions, with the goal being to construct an EFEMP1-derived tumor-suppressor protein (ETSP) that lacked tumor-promoting function. Exon/intron boundaries of EFEMP1 were used as boundaries of functional modules in constructing EFEMP1 variants, with removal of various module(s), and/or mutating an amino acid residue to convert a weak integrin binding-site into a strong one...
2016: Oncoscience
https://www.readbyqxmd.com/read/27658401/evaluation-of-a-spatialized-agronomic-model-in-predicting-yield-and-n-leaching-at-the-scale-of-the-seine-normandie-basin
#10
N Beaudoin, N Gallois, P Viennot, C Le Bas, T Puech, C Schott, S Buis, B Mary
The EU directive has addressed ambitious targets concerning the quality of water bodies. Predicting water quality as affected by land use and management requires using dynamic agro-hydrogeological models. In this study, an agronomic model (STICS) and a hydrogeological model (MODCOU) have been associated in order to simulate nitrogen fluxes in the Seine-Normandie Basin, which is affected by nitrate pollution of groundwater due to intensive farming systems. This modeling platform was used to predict and understand the spatial and temporal evolution of water quality over the 1971-2013 period...
September 22, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27646836/ep03-06-reference-range-for-fetal-tricuspid-annular-plane-systolic-excursion-tapse-measurement-using-spatiotemporal-image-correlation-stic-m-mode-in-a-brazilian-population
#11
G Tedesco, L C Bussamra, L C Rolo, F S Barros, W P Martins, L Nardozza, A F Moron, E Araujo
No abstract text is available yet for this article.
September 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27646671/ep03-05-reference-values-for-fetal-heart-biometric-parameters-using-spatiotemporal-image-correlation-stic-m-mode-in-a-brazilian-population
#12
G Tedesco, L C Bussamra, L C Rolo, F S Barros, W P Martins, L Nardozza, A F Moron, E Araujo
No abstract text is available yet for this article.
September 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27646123/p03-11-absent-ductus-venosus-adv-with-intra-and-extrahepatic-shunts-demonstration-using-4d-stic-with-power-doppler
#13
R Choudhary, S B Choudhary, A Khurana
No abstract text is available yet for this article.
September 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27644792/ep06-03-investigation-of-the-usefulness-of-the-fetal-heart-screening-by%C3%A2-the-stic-method
#14
N Inamura
No abstract text is available yet for this article.
September 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27623252/occult-and-subsequent-cancer-incidence-following-risk-reducing-surgery-in-brca-mutation-carriers
#15
Mae Zakhour, Yael Danovitch, Jenny Lester, B J Rimel, Christine S Walsh, Andrew J Li, Beth Y Karlan, Ilana Cass
OBJECTIVE: To report the frequency and features of occult carcinomas and the incidence of subsequent cancers following risk-reducing salpingo-oophorectomy (RRSO) in BRCA mutation carriers. METHODS: 257 consecutive women with germline BRCA mutations who underwent RRSO between January 1, 2000 and December 31, 2014 were identified in an Institutional Review Board approved study. All patients were asymptomatic with normal physical exams, CA 125 values, and imaging studies preoperatively, and had at least 12months of follow-up post-RRSO...
September 9, 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27620006/atrial-fibrillation-post-coronary-artery-bypass-surgery-is-there-still-a-role-for-perioperative-statins-after-stics
#16
EDITORIAL
Amr F Barakat, Ahmed N Mahmoud, Islam Y Elgendy
No abstract text is available yet for this article.
August 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27600549/-learning-in-clinical-simulation-observational-study-on-satisfaction-perceived-by-students-of-nursing
#17
Ivan Rubbi, Paola Ferri, Giulia Andreina, Valeria Cremonini
INTRODUCTION: Simulation in the context of the educational workshop is becoming an important learning method, as it allows to play realistic clinical-care situations. These vocational training activities promote the development of cognitive, affective and psychomotor skills in a pedagogical context safe and risk-free, but need to be accounted for using by valid and reliable instruments. AIM: To inspect the level of satisfaction of the students of a Degree in Nursing in northern Italy about static and high-fidelity exercises with simulators and clinical cases...
April 2016: Professioni Infermieristiche
https://www.readbyqxmd.com/read/27596940/using-biophysical-models-to-manage-nitrogen-pollution-from-agricultural-sources-utopic-or-realistic-approach-for-non-scientist-users-case-study-of-a-drinking-water-catchment-area-in-lorraine-france
#18
Pierre-Yves Bernard, Marc Benoît, Jean Roger-Estrade, Sylvain Plantureux
The objectives of this comparison of two biophysical models of nitrogen losses were to evaluate first whether results were similar and second whether both were equally practical for use by non-scientist users. Results were obtained with the crop model STICS and the environmental model AGRIFLUX based on nitrogen loss simulations across a small groundwater catchment area (<1 km(2)) located in the Lorraine region in France. Both models simulate the influences of leaching and cropping systems on nitrogen losses in a relevant manner...
December 1, 2016: Journal of Environmental Management
https://www.readbyqxmd.com/read/27488216/incidence-and-characteristics-of-unsuspected-neoplasia-discovered-in-high-risk-women-undergoing-risk-reductive-bilateral-salpingooophorectomy
#19
Carolin Poon, Simon Hyde, Peter Grant, Marsali Newman, Kerryn Ireland Jenkin
OBJECTIVE: Risk reducing salpingooophorectomy is recommended to women with a BReast CAncer susceptibility gene (BRCA) 1 or 2 germline mutation to reduce the risk of ovarian cancer. The incidence of unsuspected neoplasia varies in the literature. The purpose of this study was to identify the rate of unsuspected neoplasia in a high-risk Australian population, discuss their management, and assess the clinical outcome. METHOD: This is a retrospective review of all women undergoing risk reductive salpingooophorectomy between January 2006 and December 2014...
October 2016: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27449340/development-of-an-image-mean-square-displacement-imsd-based-method-as-a-novel-approach-to-study-the-intracellular-trafficking-of-nanoparticles
#20
Luca Digiacomo, Michelle A Digman, Enrico Gratton, Giulio Caracciolo
UNLABELLED: Fluorescence microscopy and spectroscopy techniques are commonly used to investigate complex and interacting biological systems (e.g. proteins and nanoparticles in living cells), since these techniques can explore intracellular dynamics with high time resolution at the nanoscale. Here we extended one of the Image Correlation Spectroscopy (ICS) methods, i.e. the image Mean Square Displacement, in order to study 2-dimensional diffusive and flow motion in confined systems, whose driving speed is uniformly distributed in a variable angular range...
September 15, 2016: Acta Biomaterialia
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