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Hao Chen, Robert Klein, Stacy Arnold, Setsuko Chambers, Wenxin Zheng
BACKGROUND: Mounting evidence suggests the fallopian tube as the origin for ovarian high grade serous carcinoma (HGSC). We attempted to identify the tubal cytological features that allow us to distinguish malignant from benign conditions. METHODS: Tubal specimens (n = 56) were collected from patients who underwent bilateral salpingo-oophorectomy (BSO) due to various clinical indications. A standard procedure to collect fallopian tube brushings from freshly received surgical specimens was developed...
2016: Cancer Cell International
Vit Weinberger, Marketa Bednarikova, David Cibula, Michal Zikan
Introduction Serous tubal intraepithelial carcinoma (STIC) is most likely precursor lesion of the most part of high-grade serous pelvis carcinomas, carcinosarcoma and undifferentiated carcinoma with incidence of 0.6% to 7% in BRCA carriers or women with strong family history of breast or ovarian carcinoma. STIC is a pathomorphologically and immunohistochemically detectable lesion which biological significance and clinical relevance is unknown. Areas covered We investigate methods of STIC diagnostics and we present an overview of recent studies and available knowledge on surgical management, adjuvant chemotherapy and subsequent follow-up procedure in women with an isolated STIC...
October 12, 2016: Expert Review of Anticancer Therapy
Neha Mittal, Radhika Srinivasan, Nalini Gupta, Arvind Rajwanshi, Raje Nijhawan, Upasana Gautam, Swati Sood, Lakhbir Dhaliwal
CONTEXT: High-grade serous carcinomas of ovarian, tubal, and peritoneal origin are together referred as pelvic serous carcinoma. The fallopian tubes, ovarian surface epithelium, and the tuboperitoneal junctional epithelium are all implicated in pelvic serous carcinogenesis. AIMS: The aim of this study is to identify putative precursor lesions of serous carcinoma including secretory cell outgrowths (SCOUTs), serous tubal intraepithelial carcinoma (STIC), and p53 signatures and assign its probable site of origin...
October 2016: Indian Journal of Pathology & Microbiology
Yi-Hong Zhou, Yuanjie Hu, Liping Yu, Chao Ke, Christopher Vo, Hao Hsu, Zhenzhi Li, Anne T Di Donato, Abhishek Chaturbedi, Ji Won Hwang, Eric R Siegel, Mark E Linskey
De-regulated EFEMP1 gene expression in solid tumors has been widely reported with conflicting roles. We dissected EFEMP1 to identify domains responsible for its cell context-dependent dual functions, with the goal being to construct an EFEMP1-derived tumor-suppressor protein (ETSP) that lacked tumor-promoting function. Exon/intron boundaries of EFEMP1 were used as boundaries of functional modules in constructing EFEMP1 variants, with removal of various module(s), and/or mutating an amino acid residue to convert a weak integrin binding-site into a strong one...
2016: Oncoscience
N Beaudoin, N Gallois, P Viennot, C Le Bas, T Puech, C Schott, S Buis, B Mary
The EU directive has addressed ambitious targets concerning the quality of water bodies. Predicting water quality as affected by land use and management requires using dynamic agro-hydrogeological models. In this study, an agronomic model (STICS) and a hydrogeological model (MODCOU) have been associated in order to simulate nitrogen fluxes in the Seine-Normandie Basin, which is affected by nitrate pollution of groundwater due to intensive farming systems. This modeling platform was used to predict and understand the spatial and temporal evolution of water quality over the 1971-2013 period...
September 22, 2016: Environmental Science and Pollution Research International
G Tedesco, L C Bussamra, L C Rolo, F S Barros, W P Martins, L Nardozza, A F Moron, E Araujo
No abstract text is available yet for this article.
September 2016: Ultrasound in Obstetrics & Gynecology
G Tedesco, L C Bussamra, L C Rolo, F S Barros, W P Martins, L Nardozza, A F Moron, E Araujo
No abstract text is available yet for this article.
September 2016: Ultrasound in Obstetrics & Gynecology
R Choudhary, S B Choudhary, A Khurana
No abstract text is available yet for this article.
September 2016: Ultrasound in Obstetrics & Gynecology
N Inamura
No abstract text is available yet for this article.
September 2016: Ultrasound in Obstetrics & Gynecology
Mae Zakhour, Yael Danovitch, Jenny Lester, B J Rimel, Christine S Walsh, Andrew J Li, Beth Y Karlan, Ilana Cass
OBJECTIVE: To report the frequency and features of occult carcinomas and the incidence of subsequent cancers following risk-reducing salpingo-oophorectomy (RRSO) in BRCA mutation carriers. METHODS: 257 consecutive women with germline BRCA mutations who underwent RRSO between January 1, 2000 and December 31, 2014 were identified in an Institutional Review Board approved study. All patients were asymptomatic with normal physical exams, CA 125 values, and imaging studies preoperatively, and had at least 12months of follow-up post-RRSO...
September 9, 2016: Gynecologic Oncology
Amr F Barakat, Ahmed N Mahmoud, Islam Y Elgendy
No abstract text is available yet for this article.
August 2016: Journal of Thoracic Disease
Ivan Rubbi, Paola Ferri, Giulia Andreina, Valeria Cremonini
INTRODUCTION: Simulation in the context of the educational workshop is becoming an important learning method, as it allows to play realistic clinical-care situations. These vocational training activities promote the development of cognitive, affective and psychomotor skills in a pedagogical context safe and risk-free, but need to be accounted for using by valid and reliable instruments. AIM: To inspect the level of satisfaction of the students of a Degree in Nursing in northern Italy about static and high-fidelity exercises with simulators and clinical cases...
April 2016: Professioni Infermieristiche
Pierre-Yves Bernard, Marc Benoît, Jean Roger-Estrade, Sylvain Plantureux
The objectives of this comparison of two biophysical models of nitrogen losses were to evaluate first whether results were similar and second whether both were equally practical for use by non-scientist users. Results were obtained with the crop model STICS and the environmental model AGRIFLUX based on nitrogen loss simulations across a small groundwater catchment area (<1 km(2)) located in the Lorraine region in France. Both models simulate the influences of leaching and cropping systems on nitrogen losses in a relevant manner...
December 1, 2016: Journal of Environmental Management
Carolin Poon, Simon Hyde, Peter Grant, Marsali Newman, Kerryn Ireland Jenkin
OBJECTIVE: Risk reducing salpingooophorectomy is recommended to women with a BReast CAncer susceptibility gene (BRCA) 1 or 2 germline mutation to reduce the risk of ovarian cancer. The incidence of unsuspected neoplasia varies in the literature. The purpose of this study was to identify the rate of unsuspected neoplasia in a high-risk Australian population, discuss their management, and assess the clinical outcome. METHOD: This is a retrospective review of all women undergoing risk reductive salpingooophorectomy between January 2006 and December 2014...
October 2016: International Journal of Gynecological Cancer
Luca Digiacomo, Michelle A Digman, Enrico Gratton, Giulio Caracciolo
UNLABELLED: Fluorescence microscopy and spectroscopy techniques are commonly used to investigate complex and interacting biological systems (e.g. proteins and nanoparticles in living cells), since these techniques can explore intracellular dynamics with high time resolution at the nanoscale. Here we extended one of the Image Correlation Spectroscopy (ICS) methods, i.e. the image Mean Square Displacement, in order to study 2-dimensional diffusive and flow motion in confined systems, whose driving speed is uniformly distributed in a variable angular range...
September 15, 2016: Acta Biomaterialia
Lukasz T Polanski, Miriam N Baumgarten, Jan Brosens, Siobhan Quenby, Bruce Campbell, Wellington Martins, Nick Raine-Fenning
OBJECTIVE: The aim of this study was to correlate manual and spherical endometrial spatio-temporal image correlation (STIC) vascularity indices with assisted reproductive treatment (ART) outcomes. STUDY DESIGN: STIC ultrasound assessments of the endometrium were carried out at three time-points in 127 women in a prospective observational study. RESULTS: Biochemical pregnancy rate was 69% (88/127), with a biochemical and clinical pregnancy loss of 17%...
August 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Alicja Ziętek, Michał Bogusiewicz, Justyna Szumiło, Tomasz Rechberger
Ovarian cancer is the most malignant and aggressive gynecological cancer. Due to nonspecific symptoms in the early stage and a lack of effective screening methods, it is typically diagnosed at an advanced stage. The high-grade serous cancer (HGSC) represents 75% of all ovarian cancers and accounts for the majority of deaths. Contemporary thought suggests that precursor lesions of HGSC originate in the fallopian tube. The presumed precursor tubal lesion, localized at the fimbrial end of the fallopian tubes, is termed the serous tubal intraepithelial carcinoma (STIC)...
2016: Ginekologia Polska
H Yoshida, D Shintani, Y Imai, K Fujiwara
Serous tubal intraepithelial carcinoma (STIC) is considered the precursor of pelvic serous carcinomas and the earliest malignant alteration in BRCA mutation-positive women. Recently, risk-reducing salpingo-oophorectomy (RRSO) is being performed in BRCA mutation-positive women and STIC is often discovered incidentally in the fallopian tubes. A 62-year-old woman underwent bilateral salpingo-oophorectomy (BSO) for ovarian cysts. Ten months later, cytological screening for the endometrium revealed adenocarcinoma...
2016: European Journal of Gynaecological Oncology
Liqing Zhao, Yurong Wu, Sun Chen, Yunyun Ren, Ping Chen, Jianmei Niu, Cao Li, Kun Sun
OBJECTIVE: This study aimed at investigating the feasibility of using the spatiotemporal image correlation (STIC) technology for prenatal cardiac screening, finding factors that influence the offline evaluation of reconstructed fetal heart, and establishing an optimal acquisition scheme. METHODS: The study included 452 gravidae presenting for routine screening at 3 maternity centers at 20-38 gestational weeks. The factors influencing the quality of STIC volume data were evaluated using t test, chi-square test, and logistic regression analysis...
2016: PloS One
Paola Veronese, Gianna Bogana, Alessia Cerutti, Lami Yeo, Roberto Romero, Maria Teresa Gervasi
OBJECTIVE: To evaluate the performance of Fetal Intelligent Navigation Echocardiography (FINE) applied to spatiotemporal image correlation (STIC) volume datasets of the normal fetal heart in generating standard fetal echocardiography views. METHODS: In this prospective cohort study of patients with normal fetal hearts (19-30 gestational weeks), one or more STIC volume datasets were obtained of the apical four-chamber view. Each STIC volume successfully obtained was evaluated by STICLoop™ to determine its appropriateness before applying the FINE method...
June 17, 2016: Fetal Diagnosis and Therapy
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