Alice Melocchi, Brigitte Schmittlein, Alexis L Jones, Yasmine Ainane, Ali Rizvi, Darius Chan, Elaine Dickey, Kelsey Pool, Kenny Harsono, Dorothy Szymkiewicz, Umberto Scarfogliero, Varun Bhatia, Amlesh Sivanantham, Nadia Kreciglowa, Allison Hunter, Miguel Gomez, Adrian Tanner, Marco Uboldi, Arpit Batish, Joanna Balcerek, Mariella Kutova-Stoilova, Sreenivasan Paruthiyil, Luis A Acevedo, Rachel Stadnitskiy, Sabrina Carmichael, Holger Aulbach, Matthew Hewitt, Xavier De Mollerat Du Jeu, Benedetta di Robilant, Federico Parietti, Jonathan H Esensten
BACKGROUND AIMS: The production of commercial autologous cell therapies such as chimeric antigen receptor T cells requires complex manual manufacturing processes. Skilled labor costs and challenges in manufacturing scale-out have contributed to high prices for these products. METHODS: We present a robotic system that uses industry-standard cell therapy manufacturing equipment to automate the steps involved in cell therapy manufacturing. The robotic cluster consists of a robotic arm and customized modules, allowing the robot to manipulate a variety of standard cell therapy instruments and materials such as incubators, bioreactors, and reagent bags...
March 15, 2024: Cytotherapy