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BIA-ALCL

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https://www.readbyqxmd.com/read/29280860/mbn-2016-aesthetic-breast-meeting-bia-alcl-consensus-conference-report
#1
Maurizio Bruno Nava, William P Adams, Giovanni Botti, Antonella Campanale, Giuseppe Catanuto, Mark W Clemens, Daniel A Del Vecchio, Roy De Vita, Arianna Di Napoli, Elisabeth Hall-Findlay, Dennis Hammond, Per Heden, Patrick Mallucci, Josè Luis Martin Del Yerro, Egle Muti, Alberto Rancati, Charles Randquist, Marzia Salgarello, Constantin Stan, Nicola Rocco
Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is an uncommon neoplasia occurring in women with either cosmetic or reconstructive breast implants. The actual knowledge about BIA-ALCL deriving from the literature presents several limits, and it remains difficult to make inferences about BIA-ALCL epidemiology, cause, and pathogenesis. This is the reason why the authors decided to organize an evidence-based consensus conference during the Maurizio Bruno Nava (MBN 2016) Aesthetic Breast Meeting held in Milan in December of 2016...
January 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29280858/22-cases-of-breast-implant-associated-alcl-awareness-and-outcome-tracking-from-the-italian-ministry-of-health
#2
Antonella Campanale, Rosaria Boldrini, Marcella Marletta
BACKGROUND: To date, 359 cases of anaplastic large cell lymphoma (ALCL) in women with breast implants (breast implant-associated ALCL [BIA-ALCL]) worldwide have been reported among more than 10 million patients who have received implants, but health care authorities suspect this is a possible underestimation, and the limited number of cases makes it difficult to clarify its cause. The General Directorate of Medical Devices and Pharmaceutical Services of the Italian Ministry of Health has examined and studied the Italian BIA-ALCL cases...
January 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29225983/breast-implant-associated-anaplastic-large-cell-lymphoma-a-case-report-and-review-of-the-literature
#3
Daniel E Ezekwudo, Tolulope Ifabiyi, Bolanle Gbadamosi, Kristle Haberichter, Zhou Yu, Mitual Amin, Kenneth Shaheen, Michael Stender, Ishmael Jaiyesimi
Breast implant-associated anaplastic large T-cell lymphoma has recently been recognized as an entity, with few reports describing the two common subtypes: in situ (indolent) and infiltrative. Recently, the infiltrative subtypes have been shown to be more aggressive requiring adjuvant chemotherapy. We report a rare case of breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) in a 65-year-old Caucasian female following silicone breast implantation and multiple capsulectomies. We discuss the rare presentation of this disease, histopathologic features of the indolent and infiltrative subtypes of ALCL, and their clinical significance...
2017: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/29101436/anaplastic-large-cell-lymphoma-associated-with-breast-implants-a-case-report-of-a-transgender-female
#4
Matej Patzelt, Lucie Zarubova, Pavel Klener, Josef Barta, Kamila Benkova, Adrianna Brandejsova, Marek Trneny, Robert Gürlich, Andrej Sukop
Breast implant-associated anaplastic large-cell lymphoma (BIA-ALCL) is a rare peripheral T cell lymphoma. BIA-ALCL is a disease of the fibrous capsule surrounding the implant and occurs in patients after both breast reconstruction and augmentation. More than 300 cases have been reported so far, including two in a transgender patient. Here we describe BIA-ALCL presented with a mass in a transgender patient and the first case of BIA-ALCL in the Czech Republic. In 2007, a 33-year-old transgender male to female underwent bilateral breast augmentation as a part of his transformation to female...
November 3, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29049466/breast-implant-associated-anaplastic-large-cell-lymphoma-a-systematic-review
#5
Ashley N Leberfinger, Brittany J Behar, Nicole C Williams, Kevin L Rakszawski, John D Potochny, Donald R Mackay, Dino J Ravnic
Importance: Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL), a rare peripheral T-cell lymphoma, is increasing in incidence. However, many practitioners who treat patients with breast cancer are not aware of this disease. Objectives: To assess how BIA-ALCL develops, its risk factors, diagnosis, and subsequent treatment and to disseminate information about this entity to the medical field. Evidence Review: A literature review was performed in an academic medical setting...
October 18, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/29040370/long-term-safety-of-textured-and-smooth-breast-implants
#6
M Bradley Calobrace, Michael R Schwartz, Kamakshi R Zeidler, Troy A Pittman, Robert Cohen, W Grant Stevens
In this review, the authors provide a 20-year review and comparison of implant options and describe the evolution of breast implant surface textures; compare available implant surfaces; present long-term safety data from the 10-year US-based Core clinical studies; list the key benefits and risks associated with smooth and textured implants; and provide perspectives on breast implant-associated anaplastic large cell lymphoma (BIA-ALCL). The authors explore the key benefits and risks associated with all available devices so that optimal and safe patient outcomes can be achieved...
September 28, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29036945/what-s-your-micromort-a-patient-oriented-analysis-of-breast-implant-associated-anaplastic-large-cell-lymphoma-bia-alcl
#7
David A Sieber, William P Adams
Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) continues to be a rare and elusive malignancy. Because BIA-ALCL does not behave like traditional lymphomas, additional research needs to be conducted to further delineate the lymphoproliferative nature of BIA-ALCL. An estimated 35 million women worldwide have breast implants and the total reported deaths from BIA-ALCL is 12 to date. The term micromort was introduced in 1979 by Ronald Howard as a person's risk of dying as 1 in a million. Drinking 0...
September 1, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29036941/breast-implant-associated-anaplastic-large-cell-lymphoma-in-a-transgender-woman
#8
Mintsje de Boer, Wouter B van der Sluis, Jan P de Boer, Lucy I H Overbeek, Flora E van Leeuwen, Hinne A Rakhorst, René R W J van der Hulst, Nathalie J Hijmering, Mark-Bram Bouman, Daphne de Jong
Breast implant-associated anaplastic large-cell lymphoma (BIA-ALCL) is a rare but serious complication in patients with breast implants, Patients are at risk of BIA-ALCL whether they receive breast implants for cosmetic reasons or for reconstructive purposes after surgery for breast cancer or prophylactic mastectomy. During the past decade, an increased number of reports have addressed BIA-ALCL. Herein, we describe BIA-ALCL in a transgender woman. The patient received breast implants as part of her gender transition and was diagnosed with BIA-ALCL 20 years later...
September 1, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29025239/response-to-breast-implant-associated-anaplastic-large-cell-lymphoma-bia-alcl-why-the-search-for-an-infectious-etiology-may-be-irrelevant
#9
Anand K Deva
No abstract text is available yet for this article.
October 1, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29025238/breast-implant-associated-anaplastic-large-cell-lymphoma-bia-alcl-why-the-search-for-an-infectious-etiology-may-be-irrelevant
#10
Eric Swanson
No abstract text is available yet for this article.
October 1, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/28915212/22-cases-of-bia-alcl-awareness-and-outcome-tracking-from-the-italian-ministry-of-health
#11
Campanale Antonella, Boldrini Rosaria, Marletta Marcella
BACKGROUND: To date, 359 cases of anaplastic large cell lymphoma in women with breast implants (BIA-ALCL) worldwide have been reported out of more than 10 million implanted patients but Health Care Authorities suspect this is a possible underestimation and the limited number of cases makes it difficult to clarify its etiology. The General Directorate of Medical Devices and Pharmaceutical Services of the Italian Ministry of Health (IMoH) has examined and studied the Italian BIA-ALCL cases, and the aim of this study is to report on the knowledge and experience gained on this new emerging disease...
September 13, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28762113/implications-of-breast-implant-associated-anaplastic-large-cell-lymphoma-bia-alcl-for-breast-cancer-reconstruction-an-update-for-surgical-oncologists
#12
Anne C O'Neill, Toni Zhong, Stefan O P Hofer
Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a rare disease that has been diagnosed in an extremely small proportion of women with breast implants. The pathogenesis of this disease is currently poorly understood, but it appears to be related to textured implants. Recent high-profile media coverage of this rare clinical entity is likely to cause considerable anxiety for breast cancer patients who have undergone alloplastic breast reconstruction. The purpose of this review is to provide surgical oncologists with an evidence-based overview of the incidence, diagnosis, and management of BIA-ALCL with a particular emphasis on breast reconstruction cases...
October 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28596034/breast-implant-associated-anaplastic-large-cell-lymphoma-the-uk-experience-recommendations-on-its-management-and-implications-for-informed-consent
#13
L Johnson, J M O'Donoghue, N McLean, P Turton, A A Khan, S D Turner, A Lennard, N Collis, M Butterworth, G Gui, J Bristol, J Hurren, S Smith, K Grover, G Spyrou, K Krupa, I A Azmy, I E Young, J J Staiano, H Khalil, F A MacNeill
BACKGROUND: Breast implant-associated anaplastic large-cell lymphoma (BIA-ALCL) is a rare, Non-Hodgkin lymphoma arising in the capsule of breast implants. BIA-ALCL presents as a recurrent effusion and/or mass. Tumours exhibit CD30 expression and are negative for Anaplastic Lymphoma Kinase (ALK). We report the multi-disciplinary management of the UK series and how the stage of disease may be used to stratify treatment. METHODS: Between 2012 and 2016, 23 cases of BIA-ALCL were diagnosed in 15 regional centres throughout the UK...
August 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28481803/breast-implant-associated-anaplastic-large-cell-lymphoma-in-australia-and-new-zealand-high-surface-area-textured-implants-are-associated-with-increased-risk
#14
MULTICENTER STUDY
Anna Loch-Wilkinson, Kenneth J Beath, Robert John William Knight, William Louis Fick Wessels, Mark Magnusson, Tim Papadopoulos, Tony Connell, Julian Lofts, Michelle Locke, Ingrid Hopper, Rodney Cooter, Karen Vickery, Preeti Avinash Joshi, H Miles Prince, Anand K Deva
BACKGROUND: The association between breast implants and breast implant-associated anaplastic large cell lymphoma (ALCL) has been confirmed. Implant-related risk has been difficult to estimate to date due to incomplete datasets. METHODS: All cases in Australia and New Zealand were identified and analyzed. Textured implants reported in this group were subjected to surface area analysis. Sales data from three leading breast implant manufacturers (i.e., Mentor, Allergan, and Silimed) dating back to 1999 were secured to estimate implant-specific risk...
October 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28413663/breast-implant-associated-anaplastic-large-cell-lymphoma-and-the-role-of-brentuximab-vedotin-sgn-35-therapy-a-case-report-and-review-of-the-literature
#15
Kristin Richardson, Taha Alrifai, Kelly Grant-Szymanski, George J Kouris, Parameswaran Venugopal, Brett Mahon, Reem Karmali
Breast implant-associated (BIA) anaplastic large-cell lymphoma (ALCL) is a rare disease, comprising a small percentage of all non-Hodgkin lymphomas (NHLs), reportedly 2-3%. There is currently no established standard approach to the treatment of BIA ALCL. The first case on the development of ALCL in the presence of a breast implant was reported in 1997 and the association was first identified by the Food and Drug Administration in 2011. We herein describe a case of BIA ALCL in a patient with a previous history of breast cancer and breast reconstruction who presented with hardening of her breast implant...
April 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/26979456/biomarkers-provide-clues-to-early-events-in-the-pathogenesis-of-breast-implant-associated-anaplastic-large-cell-lymphoma
#16
Marshall E Kadin, Anand Deva, Haiying Xu, John Morgan, Pranay Khare, Roderick A F MacLeod, Bruce W Van Natta, William P Adams, Garry S Brody, Alan L Epstein
Almost 200 women worldwide have been diagnosed with breast implant-associated anaplastic large cell lymphoma (BIA-ALCL). The unique location and specific lymphoma type strongly suggest an etio-pathologic link between breast implants and BIA-ALCL. It is postulated that chronic inflammation via bacterial infection may be an etiological factor. BIA-ALCL resembles primary cutaneous ALCL (pcALCL) in morphology, activated T-cell phenotype, and indolent clinical course. Gene expression array analysis, flow cytometry, and immunohistochemistry were used to study pcALCL and BIA-ALCL cell lines...
July 2016: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/26956974/mscs-and-inflammation-new-insights-into-the-potential-association-between-alcl-and-breast-implants
#17
M Orciani, G Sorgentoni, M Torresetti, Roberto Di Primio, G Di Benedetto
Possible association between anaplastic large cell lymphoma (ALCL) and breast implants has been suggested. In this context, formation of the periprosthetic capsule has been reported as a cause of inflammation, which plays a key role in tumor onset. Tumors take advantage of inflammation to influence and interfere with the host immune response by secreting multiple factors, and their onset and survival is in turn affected by the paracrine effects from mesenchymal stem cells (MSCs). In this study, we tried to clarify how inflammation can modify the immunobiology and the exerted paracrine effect of MSCs...
February 2016: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/26890506/bacterial-biofilm-infection-detected-in-breast-implant-associated-anaplastic-large-cell-lymphoma
#18
MULTICENTER STUDY
Honghua Hu, Khalid Johani, Ahmad Almatroudi, Karen Vickery, Bruce Van Natta, Marshall E Kadin, Garry Brody, Mark Clemens, Chan Yoon Cheah, Stephen Lade, Preeti Avinash Joshi, H Miles Prince, Anand K Deva
BACKGROUND: A recent association between breast implants and the development of anaplastic large-cell lymphoma (ALCL) has been observed. The purpose of this study was to identify whether bacterial biofilm is present in breast implant-associated ALCL and, if so, to compare the bacterial microbiome to nontumor capsule samples from breast implants with contracture. METHODS: Twenty-six breast implant-associated ALCL samples were analyzed for the presence of biofilm by real-time quantitative polymerase chain reaction, next-generation sequencing, fluorescent in situ hybridization, and scanning electron microscopy, and compared to 62 nontumor capsule specimens...
June 2016: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/26617170/-breast-implant-associated-anaplastic-large-cell-lymphoma
#19
Reem Dina Jarjis, Steen Henrik Matzen
Breast implant-associated anaplastic large-cell lymphoma (BIA-ALCL) is a rare entity. Due to the lack of awareness of BIA-ALCL, patients with prior history of breast implants who present with non-specific implant-related complications might experience a delay in diagnosis and appropriate treatment of this distinct condition. There are still no evidence-based guidelines on how this condition should be diagnosed, treated or followed because of the rarity of available data. We review current literature in order to raise awareness and discuss management options of this unique clinical entity...
November 23, 2015: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/25674377/breast-implant-associated-anaplastic-large-cell-lymphoma-updated-results-from-a-structured-expert-consultation-process
#20
Benjamin Kim, Zachary S Predmore, Soeren Mattke, Kristin van Busum, Courtney A Gidengil
BACKGROUND: Despite increased cases published on breast implant-associated anaplastic large cell lymphoma (BIA-ALCL), important clinical issues remain unanswered. We conducted a second structured expert consultation process to rate statements related to the diagnosis, management, and surveillance of this disease, based on their interpretation of published evidence. METHODS: A multidisciplinary panel of 12 experts was selected based on nominations from national specialty societies, academic department heads, and recognized researchers in the United States...
January 2015: Plastic and Reconstructive Surgery. Global Open
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