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Type 2diabetes

Amilcar Rivera Rivera, Linette Castillo-Pichardo, Yamil Gerena, Suranganie Dharmawardhane
The Akt/adenosine monophosphate protein kinase (AMPK)/mammalian target of rapamycin (mTOR) pathway has emerged as a critical signaling nexus for regulating cellular metabolism, energy homeostasis, and cell growth. Thus, dysregulation of this pathway contributes to the development of metabolic disorders such as obesity, type 2diabetes, and cancer. We previously reported that a combination of grape polyphenols (resveratrol, quercetin and catechin: RQC), at equimolar concentrations, reduces breast cancer (BC) growth and metastasis in nude mice, and inhibits Akt and mTOR activities and activates AMPK, an endogenous inhibitor of mTOR, in metastatic BC cells...
2016: PloS One
Akhilesh Jain, Rekha Sharma, Pavan Kumar Choudhary, Neelam Yadav, Garima Jain, Mukesh Maanju
INTRODUCTION: Type 2 diabetes mellitus is a significant health problem and imposes great physical, financial and psychological burden among the affected population. Among people with diabetes, fatigue is a pervasive and distressing complaint, which is further accentuated by presence of depression. OBJECTIVE: To assess the prevalence of fatigue and depression and associated clinical and socio demographic correlates in type 2diabetes. MATERIALS AND METHODS: This cross sectional study included 100 patients of diabetes type 2 and equal number of healthy controls between the ages of 18 to 70 years...
July 2015: Industrial Psychiatry Journal
Rebecca K West, Ramit Ravona-Springer, Anthony Heymann, James Schmeidler, Derek Leroith, Keren Koifman, Ryan C N D'Arcy, Xiaowei Song, Elizabeth Guerrero-Berroa, Rachel Preiss, Hadas Hoffman, Mary Sano, Jeremy M Silverman, Michal Schnaider-Beeri
INTRODUCTION: Waist circumference is associated with type 2 diabetes (T2D) and cognition, yet the relationship between waist circumference and cognition in individuals with T2D is not well understood. METHODS: We studied the relationship of waist circumference with five cognitive outcomes (executive functioning, language/semantic categorization, attention/working memory, episodic memory, and an overall cognition measure) in 845 cognitively normal elderly with type 2 diabetes (T2D)...
August 2016: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
Abdo Jurjus, Assad Eid, Sahar Al Kattar, Marie Noel Zeenny, Alice Gerges-Geagea, Hanine Haydar, Anis Hilal, Doreid Oueidat, Michel Matar, Jihane Tawilah, Inaya Hajj Hussein, Pierre Schembri-Wismayer, Francesco Cappello, Giovanni Tomasello, Angelo Leone, Rosalyn A Jurjus
The co-occurrence of the three disease entities, inflammatory bowel disease (IBD), colorectal cancer (CRC), type 2diabetes mellitus (T2DM) along with inflammation and dismicrobism has been frequently reported. Some authors have even suggested that dysbiosis could be the link through a molecular crosstalk of multiple inflammatory loops including TGFβ, NFKB, TNFα and ROS among others. This review focuses on the inflammatory process along with the role of microbiota in the pathophysiology of the three diseases...
June 2016: BBA Clinical
Lyudmila P Dolgacheva, Maria V Turovskaya, Vladimir V Dynnik, Valery P Zinchenko, Nikolay V Goncharov, Bazbek Davletov, Egor A Turovsky
Angiotensin II (Ang II) is an important mammalian neurohormone involved in reninangiotensin system. Ang II is produced both constitutively and locally by RAS systems, including white fat adipocytes. The influence of Ang II on adipocytes is complex, affecting different systems of signal transduction from early Са(2+) responses to cell proliferation and differentiation, triglyceride accumulation, expression of adipokine-encoding genes and adipokine secretion. It is known that white fat adipocytes express all RAS components and Ang II receptors (АТ1 and АТ2)...
March 1, 2016: Archives of Biochemistry and Biophysics
Tung Po Wong, Leo Ka Yu Chan, Po Sing Leung
Niacin is a popular nutritional supplement known to reduce the risk of cardiovascular diseases by enhancing high-density lipoprotein levels. Despite such health benefits, niacin impairs fasting blood glucose. In type 2 diabetes (T2DM), an increase in jejunal glucose transport has been well documented; however, this is intriguingly decreased during niacin deficient state. In this regard, the role of the niacin receptor GPR109a in T2DM jejunal glucose transport remains unknown. Therefore, the effects of diabetes and high-glucose conditions on GPR109a expression were studied using jejunal enterocytes of 10-week-old m+/db and db/db mice, as well as Caco-2 cells cultured in 5...
September 2015: Nutrients
Ying Liu, Shu-Qin Chen, Zhao-Hai Jing, Xu Hou, Ying Chen, Xue-Jia Song, Wen-Shan Lv, Robin Wang, Yan-Gang Wang
A meta-analysis was conducted to evaluate the association of LEPR Gln223Arg polymorphism with type 2diabetes (T2DM). Sixteen individual studies with 7827 subjects were included into the meta-analysis. Current studies suggest that LEPR Gln223Arg polymorphism may not affect the susceptibility with type 2diabetes (T2DM).
September 2015: Diabetes Research and Clinical Practice
Nirmali Mattack, Runi Devi, Tridip Kutum, Dibyaratna Patgiri
INTRODUCTION AND AIM: Type 2 diabetes mellitus (T2DM) is the predominant form of diabetes worldwide and much is known about its patho-physiology. Yet, newer aspects related to it are being constantly explored. For ages, testosterone has been known to men as the male sex hormone but now it has been shown by certain studies that it might have a role in the development of metabolic disorders like type 2 diabetes. This study was carried out to determine the relation of testosterone levels with type 2 diabetes mellitus and lipid profile in North East Indian men aged 31 to 73 years...
January 2015: Journal of Clinical and Diagnostic Research: JCDR
Farzad Shidfar, Mitra Zarrati, Mohamad Ebrahim Khamseh, Neda Haghighat, Ali Rostami, Hamid Zolfaghari
BACKGROUND: Some results exist on fetuin-A as marker for vascular disease in type 2diabetes. We examined the relationship between serum fetuin-A with some factors, in patients with type 2 diabetes mellitus (T2DM). METHODS: From October 2012 to June 2013, a total of 131 T2DM patients were recruited and evaluated for various parameters including HOMA-IR, Apo-A1, Apo-B100, body fat percentage and waist circumference. Serum fetuin-A levels were measured by enzyme-linkedimmunosorbent assay (ELISA), and Serum glucose with a Cobas MIRA analyzer by enzymatic method...
2014: Medical Journal of the Islamic Republic of Iran
Guoyue Yuan, Jue Jia, Caili Zhang, Shuqin Yu, Sijing Dong, Jingjing Ye, Tianyi Zhu, Bingqian Tang, Weiyun Qian, Dong Wang, Ling Yang, Libin Zhou, Chaoming Mao
Sitagliptin was used as monotherapy or in combination with metformin, thiazolidinedione or sulfonylurea. It is not clear whether effects are enhanced or unique when in combination with transient continuous subcutaneous insulin infusion (CSII) therapy. The aim of this study was to assess the safety and efficacy of sitagliptin in combination with transient CSII therapy in patients with newly diagnosed type 2 diabetes. Eighty patients with newly diagnosed type 2 diabetes from July 2011 to May 2013 were recruited into the study...
2014: Endocrine Journal
Marzieh Nazaribadie, Masoud Amini, Mohammad Ahmadpanah, Karim Asgari, Somaye Jamlipaghale, Sara Nazaribadie
BACKGROUND: Diabetes is associated with cognitive decline or dementia. The purpose of this study was to assess the executive functions and information processing in patients with type 2diabetes in comparison to pre-diabetic patients and normal subjects in Endocrine and Metabolism Research Center of Isfahan City from April to July 2011. METHODS: The sample consisted of 32 patients with type 2 diabetes, 28 pre-diabetic patients and 30 healthy individuals. Executive functions were assessed by Wisconsin Card Sorting Test (WCST)...
2014: Journal of Diabetes and Metabolic Disorders
Manisha Sankhla, Tarun Kumar Sharma, Sushila Gahlot, Jai Singh Rathor, Satish Kumar Vardey, Maheep Sinha, G G Kaushik, Amita K Gadhok, Veena Singh Ghalaut, Keerti Mathur, Ragini Singh
BACKGROUND: Individuals with obesity and abdominal adiposity are at higher risk for hyperinsulinaemia, insulin resistance, and diabetes. This study was, therefore, designed to evaluate the association of both generalized and regional obesity with metabolic variables and biochemical indices. METHODS: 200 confirmed patients of type-2diabetes of either gender were studied. RESULTS: A statistically significant degree of dyslipidemia was depicted in obese class-II subjects; however, females had a lower degree of dyslipidemia as compared to male subjects with statistically significant results only for HDL-C...
2013: Clinical Laboratory
Ying Lin, Pengqiu Li, Li Cai, Ben Zhang, Xin Tang, Xuejun Zhang, Ying Li, Yang Xian, Yang Yang, Li Wang, Fang Lu, Xiaoqi Liu, Shaoqin Rao, Ming Chen, Shi Ma, Yi Shi, Mingjing Bao, Jichuan Wu, Yan Yang, Jiyun Yang, Zhenglin Yang
BACKGROUND: At least twenty genes/loci were shown to be associated with type 2diabetes in European original populations. Five of these genes were shown to be associated with type 2 diabetes (T2D) in Chinese populations. The purpose of this study was to replicate the association of genetic vairants in the eight diabetes-related genes/loci with type 2 diabetes in a Han Chinese cohort from western part of China. Nineteen single nucleotide polymorphisms (SNPs) from the eight genes/loci including TCF7L2, HHEX, CDKAL1, SLC30A8, PPARG, IGF2BP2, KCNJ11, and CDKN2A/CDKN2B were genotyped in 1,529 cases and 1,439 controls in a Han Chinese population using the ABI SNaPshot method...
2010: BMC Medical Genetics
Mahmoud Parham, Massoud Amini, Ashraf Aminorroaya, Esfandiar Heidarian
OBJECTIVES: Oxidative stress can contribute to microvascular complications in diabetes. A decisive event associated with this condition may be the decrease in the synthesis of zinc-containing antioxidant enzymes such as superoxide dismutase and glutathione peroxidase. This consideration led us to investigate the effect of zinc supplementation versus placebo on microalbuminuria in diabetic patients in a randomized double blind clinical trial. METHODS: Fifty diabetic patients with microalbuminuria were enrolled...
2008: Review of Diabetic Studies: RDS
Agnar Helgason, Snaebjörn Pálsson, Gudmar Thorleifsson, Struan F A Grant, Valur Emilsson, Steinunn Gunnarsdottir, Adebowale Adeyemo, Yuanxiu Chen, Guanjie Chen, Inga Reynisdottir, Rafn Benediktsson, Anke Hinney, Torben Hansen, Gitte Andersen, Knut Borch-Johnsen, Torben Jorgensen, Helmut Schäfer, Mezbah Faruque, Ayo Doumatey, Jie Zhou, Robert L Wilensky, Muredach P Reilly, Daniel J Rader, Yu Bagger, Claus Christiansen, Gunnar Sigurdsson, Johannes Hebebrand, Oluf Pedersen, Unnur Thorsteinsdottir, Jeffrey R Gulcher, Augustine Kong, Charles Rotimi, Kári Stefánsson
We recently described an association between risk of type 2diabetes and variants in the transcription factor 7-like 2 gene (TCF7L2; formerly TCF4), with a population attributable risk (PAR) of 17%-28% in three populations of European ancestry. Here, we refine the definition of the TCF7L2 type 2diabetes risk variant, HapB(T2D), to the ancestral T allele of a SNP, rs7903146, through replication in West African and Danish type 2 diabetes case-control studies and an expanded Icelandic study. We also identify another variant of the same gene, HapA, that shows evidence of positive selection in East Asian, European and West African populations...
February 2007: Nature Genetics
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