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Jonathan H Hsu, Benoit H Mulsant, Eric J Lenze, Marcos Sanches, Jordan F Karp, Charles F Reynolds, Daniel M Blumberger
OBJECTIVE: Augmentation with aripiprazole is an effective pharmacotherapy for treatment-resistant late-life depression (LLD). However, aripiprazole can cause extrapyramidal symptoms (EPS) such as akathisia and parkinsonism; these symptoms are distressing and can contribute to treatment discontinuation. We investigated the clinical trajectories and predictors of akathisia and parkinsonism in older patients receiving aripiprazole augmentation for treatment-resistant LLD. METHODS: Between 2009 and 2013, depressed older adults who did not remit with venlafaxine were randomized to aripiprazole or placebo in a 12-week trial...
June 19, 2018: Journal of Clinical Psychiatry
Bruno Gonçalves, Hugo Folgado, Diogo Coutinho, Rui Marcelino, Del Wong, Nuno Leite, Jaime Sampaio
Success in soccer is much dependent on how players and teams create and restrict space and time. In match situations, players constitute small sub-groups to improve their collective synchronization and achievement of specific goals. This study aimed to identify changes in the effective playing space (EPS, defined as the smallest polygonal area delimited by the peripheral outfield players) when considering sub-groups of 3 to 10 players. Twenty outfield professional players participated in this study. The EPS, its regularity pattern (measured by the approximate entropy), coefficient of variation and players' mean speed were calculated for sub-groups of 3, 4, 5, 6, 7, 8, 9 and 10 players, considering the smallest inter-player distance as the criterion...
June 2018: Journal of Human Kinetics
Qiuying Pang, Tong Zhang, Yang Wang, Wenwen Kong, Qijie Guan, Xiufeng Yan, Sixue Chen
Metabolomics has been used in unraveling metabolites that play essential roles in plant-microbe (including pathogen) interactions. However, the problem of profiling a plant metabolome with potential contaminating metabolites from the coexisting microbes has been largely ignored. To address this problem, we implemented an effective stable isotope labeling approach, where the metabolome of a plant bacterial pathogen Pseudomonas syringae pv. tomato ( Pst ) DC3000 was labeled with heavy isotopes. The labeled bacterial cells were incubated with Arabidopsis thaliana epidermal peels (EPs) with guard cells, and excessive bacterial cells were subsequently removed from the plant tissues by washing...
2018: Frontiers in Plant Science
Lisa Burry, Sangeeta Mehta, Marc M Perreault, Jay S Luxenberg, Najma Siddiqi, Brian Hutton, Dean A Fergusson, Chaim Bell, Louise Rose
BACKGROUND: Guidelines suggest limited and cautious use of antipsychotics for treatment of delirium where nonpharmacological interventions have failed and symptoms remain distressing or dangerous, or both. It is unclear how well these recommendations are supported by current evidence. OBJECTIVES: Our primary objective was to assess the efficacy of antipsychotics versus nonantipsychotics or placebo on the duration of delirium in hospitalised adults. Our secondary objectives were to compare the efficacy of: 1) antipsychotics versus nonantipsychotics or placebo on delirium severity and resolution, mortality, hospital length of stay, discharge disposition, health-related quality of life, and adverse effects; and 2) atypical vs...
June 18, 2018: Cochrane Database of Systematic Reviews
Boran Wu, Meng Zhou, Xiaohu Dai, Xiaoli Chai
This study visually tracked the micro-spatial water distribution in bio-flocs of waste activated sludge through in situ synchrotron X-ray computed microtomography. Primarily, the two fractions of bound water, the vicinal water adhering to the surface of organic compositions and the interstitial water mechanically trapped in the net-like structure of bio-flocs, were proposed based on the cross-section imaging results. Furthermore, the determinants on bound water occurrences were explored in terms of viscoelastic acoustic responses of extracellular polymeric substances (EPS)...
June 5, 2018: Water Research
Durairajan Rubini, Sanaulla Farisa Banu, Prakash Nisha, Ramar Murugan, Subbiah Thamotharan, María Judith Percino, Prabha Subramani, Paramasivam Nithyanand
In the current study we have evaluated the antibiofilm and antivirulent properties of unexplored essential oils (EOs) obtained from Pogostemon heyneanus and Cinnamomum tamala against Methicillin Resistant Staphylococcus aureus (MRSA) strains. The EOs from both the aromatic plants was screened for their ability to prevent biofilm formation and to disrupt preformed biofilms. The efficacy of both the EOs to disrupt the preformed biofilms of various MRSA strains was determined by Confocal Laser Scanning Microscopy (CLSM) and Scanning Electron Microscopy (SEM)...
June 16, 2018: Microbial Pathogenesis
Carina Graversen, Christina Brock, Jens Brøndum Frøkjær, Georg Dimcevski, Dario Farina, Asbjørn Mohr Drewes
Background/aims Electroencephalography (EEG) recorded as evoked brain potentials (EPs) reflects the cortical processing to an external event. This approach is often used to study the altered response to acute pain in chronic pain patients compared to healthy volunteers. However, discrimination of the responses from the study populations is a non-trivial task, which calls for improved objective methods. Methods To develop and validate a new methodology, we analyzed data from 16 type-1 diabetes mellitus patients and 15 age and gender matched volunteers, by means of brain activity recorded from 62 EEG channels...
December 29, 2017: Scandinavian Journal of Pain
Thomas Dahl Nissen, Carina Graversen, Steven Coen, Leif Hultin, Qasim Aziz, Jens Lykkesfeldt, Asbjørn Mohr Drewes, Christina Brock
Background In recent years only few novel drugs targeting visceral pain have been developed. This lack of success may be explained by animal models having poor predictive value. To increase the success of translating results from animals to humans there is a demand for comparable test models. The aim was to establish a comparable and reliable translational model to evoke mechanical rectal pain in rats and humans. Methods Mechanical rectal rapid balloon distension was done on two different days in 12 rats (separated by 24...
December 29, 2017: Scandinavian Journal of Pain
Christina Brock, Carina Graversen, Jens B Frøkjær, Eirik Søfteland, Massimiliano Valeriani, Asbjørn M Drewes
Background/aims Abnormal visceral sensory function in diabetes mellitus (DM) leads to neuronal changes in the enteric, peripheral and/or central nervous system (CNS). To explore the role of diabetic autonomic neuropathy (DAN) in patients with long-standing DM, we investigated psychophysical responses and neuronal activity recorded as evoked brain potentials (EPs) and dipolar source modelling. Methods Fifteen healthy volunteers and 14 type-1 DM patients with DAN were assessed with a symptom score index characterizing upper GI abnormalities...
December 29, 2017: Scandinavian Journal of Pain
Jens Brøndum Frøkjær, Søren Schou Olesen, Carina Graversen, Trine Andresen, Dina Lelic, Asbjørn Mohr Drewes
During the last decades there has been a tremendous development of non-invasive methods for assessment of brain activity following visceral pain. Improved methods for neurophysiological and brain imaging techniques have vastly increased our understanding of the central processing of gastrointestinal sensation and pain in both healthy volunteers as well as in patients suffering from gastrointestinal disorders. The techniques used are functional magnetic resonance imaging (fMRI), positron emission tomography (PET), electroencephalography (EEG)/evoked brain potentials (EPs), magnetoencephalography (MEG), single photon emission computed tomography (SPECT), and the multimodal combinations of these techniques...
December 29, 2017: Scandinavian Journal of Pain
Shaoqing Zhang, Binbin Sheng, Wenting Lin, Fangang Meng
Temperature is a well-known environmental stress that influences both microbial metabolism and community structure in the biological wastewater treatment systems. In this study, responses of biological performance and sludge microbiota to the long-term day/night temperature differences (DNTD) were investigated in membrane bioreactors (MBRs). The results showed that the functional bacteria could sustained their ecological functions at low DNTD (20/30 °C), resulting in relatively stable performance with respect to nutrient removal...
September 15, 2018: Science of the Total Environment
S Ooms, B Nemeth, J J Wever, B Knippenberg, H van Overhagen, R G Statius van Eps
OBJECTIVES: Acute Kidney Injury (AKI) after open aortic repair is subject to multiple patient- and operation-related variables. Hostile neck morphology in open aneurysm repair is thought to contribute to this AKI risk post-operatively. The aim of this study was to evaluate if large neck atheroma is a possible risk factor in the postoperative development of AKI. METHODS: Retrospectively 137 patients were evaluated for neck atheroma and AKI incidence. Atheroma load measurements were performed by two different techniques...
June 14, 2018: Annals of Vascular Surgery
Chen Gu, Jing Wang, Mengfan Guo, Meng Sui, Hong Lu, Guangfei Liu
Tetrabromobisphenol A (TBBPA) has attracted considerable attention due to its ubiquitous presence in different environmental compartments worldwide. However, information on its aerobic biodegradability in coastal environments remains unknown. Here, the aerobic biodegradation of TBBPA using a Pseudoalteromonas species commonly found in the marine environment was investigated. We found that extracellular biogenic siderophore, superoxide anion radical (O2 •- ), hydrogen peroxide (H2 O2 ), and hydroxyl radical (• OH) were involved in TBBPA degradation...
June 7, 2018: Water Research
Durairajan Rubini, Sanaulla Farisa Banu, B Narayanan Vedahari, Durai Ramyadevi, Shanmugaraj Gowrishankar, Shunmugiah Karutha Pandian, Paramasivam Nithyanand
Multidrug-resistant (MDR) Staphylococcus aureus is a major cause of biofilm-associated and indwelling device related infections. The present study explores the anti-virulent and antibiofilm potency of chitosan extracted from the shells of the marine crab Portunus sanguinolentus against Methicillin Resistant Staphylococcus aureus (MRSA). The chemical characterization results revealed that the extracted chitosan (EC) has structural analogy to that of a commercial chitosan (CC). The extracted chitosan was found to be effective in reducing the staphyloxanthin pigment, a characteristic virulence feature of MRSA that promotes resistance to reactive oxygen species...
June 13, 2018: Food and Chemical Toxicology
Yali Zhu, Zhihong Liu, Miaomiao Du, Lisha Yi, Guifang Gong, Xiang Tang
Endometrial polyps (EPs) are outgrowths in the endometrium with unknown etiology. The fact that EPs can often recur after surgical removal suggests that EPs are not induced by random events but by continuous or recurrent processes in the patients. We previously demonstrated that the risk of EP development was positively associated with overactive Th17 responses. However, the requirements of Th17 upregulation are yet unclear. Here, we recruited twenty-six females with symptomatic EP and twenty-four females without EP, and peripheral mononuclear cells were harvested for the examination of circulating immunity...
June 16, 2018: Clinical and Experimental Pharmacology & Physiology
Shuo Wang, Cong Ma, Yin Zhu, Yangkun Yang, Guocheng Du, Ji Li
FeCl3 , quick lime, and cationic polyacrylamide (CPAM) were used for excess sludge conditioning from wastewater treatment plant (WWTP) and the dewatering performance by different chemical conditioners was investigated. Experimental results showed that FeCl3 could make small and concentrated sludge particles. Furthermore, new mineral phase structures for building a dewatering framework were obtained by the addition of quick lime, and the coagulation capacity was enhanced by the formation of colloid hydroxyl polymer, which was induced due to the alkaline environment...
June 15, 2018: Environmental Science and Pollution Research International
S Longhi
Exceptional points (EPs) with a global collapse of pairs of eigenfunctions are shown to arise in two locally coupled and spatially extended optical structures with balanced gain and loss. The global collapse at the EP deeply changes light propagation, which becomes very sensitive to small changes of initial conditions or system parameters, similar to what happens in models of classical or quantum catastrophes. The implications of global collapse for light behavior are illustrated by considering discrete beam diffraction and Bloch oscillation catastrophe in coupled waveguide lattices...
June 15, 2018: Optics Letters
Quxiu Dai, Liping Ma, Nanqi Ren, Ping Ning, Zhiying Guo, Longgui Xie, Haijun Gao
Modified phosphogypsum (MPG) was developed to improve dewaterability of sewage sludge, and dewatering performance, properties of treated sludge, composition and morphology distribution of EPS, dynamic analysis and multiple regression model on bound water release were investigated. The results showed that addition of MPG caused extracellular polymeric substances (EPS) disintegration through charge neutralization. Destruction of EPS promoted the formation of larger sludge flocs and the release of bound water into supernatant...
June 6, 2018: Water Research
Qian Ping, Xiao Lu, Ming Zheng, Yongmei Li
The effect of calcium peroxide (CaO2 ) addition on anaerobic digestion (AD) of waste activated sludge (WAS) at different temperatures (20 °C, 35 °C, and 55 °C) were investigated. The results show that CaO2 addition had significant positive effect on short-chain fatty acids (SCFAs) production under ambient and mesophilic conditions. Polysaccharides and proteins embedded in extracellular polymeric substances (EPS) were effectively released from inner fraction to outer fraction, and non-biodegradable humic-like substances were decreased while easily biodegradable tryptophan-like proteins increased...
June 6, 2018: Bioresource Technology
Vitor Ramos, João Morais, Raquel Castelo-Branco, Ângela Pinheiro, Joana Martins, Ana Regueiras, Ana L Pereira, Viviana R Lopes, Bárbara Frazão, Dina Gomes, Cristiana Moreira, Maria Sofia Costa, Sébastien Brûle, Silvia Faustino, Rosário Martins, Martin Saker, Joana Osswald, Pedro N Leão, Vitor M Vasconcelos
Cyanobacteria are a well-known source of bioproducts which renders culturable strains a valuable resource for biotechnology purposes. We describe here the establishment of a cyanobacterial culture collection (CC) and present the first version of the strain catalog and its online database ( The LEGE CC holds 386 strains, mainly collected in coastal (48%), estuarine (11%), and fresh (34%) water bodies, for the most part from Portugal (84%). By following the most recent taxonomic classification, LEGE CC strains were classified into at least 46 genera from six orders (41% belong to the Synechococcales), several of them are unique among the phylogenetic diversity of the cyanobacteria...
2018: Journal of Applied Phycology
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