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Tafheem Malik, Sheema Hasan, Shahid Pervez, Tasneem Fatima, Darakhshan Jabeen Haleem
The symptoms of Parkinsonism and oral dyskinesia have been showing to be induced by neuroleptics that significantly affect its clinical use. In this study, we investigate whether Nigella sativa-oil (NS) (black cumin seeds)-a traditional medicine used for the seizure treatment in eastern country-may reduce the haloperidol (HAL)-induced extrapyramidal symptoms (EPS)-like behavior in rats. After combine treatment with HAL (1 mg/kg) on NS (0.2 ml/rat), rats displayed a significant decreased EPS-like behavior including movement disorders and oral dyskinesia as compared to controls...
October 18, 2016: Neurochemical Research
Huacheng Xu, Changming Yang, Helong Jiang
The stability/aggregation propensity of inorganic colloids in eutrophic shallow lakes is of great essence in governing the water transparency and contaminant behavior. In this study, time-resolved dynamic light scattering was employed to investigate the aggregation kinetics of Al2O3 inorganic colloids over a wide range of cyanobacterial extracellular polymeric substance (EPS) concentrations in the absence and presence of electrolyte cations. The results showed that EPS adsorption alone greatly decreased the hydrodynamic diameters of colloidal particles, whose stability behavior followed closely the predictions of the classical DLVO theory...
October 8, 2016: Water Research
Ferdi Hizal, Chang-Hwan Choi, Henk J Busscher, Henny C Van der Mei
Nanostructured surfaces are extensively considered with respect to their potential impact on bacterial adhesion from aqueous suspensions or air, but in real-life bacteria are often transmitted between surfaces. Mechanistically, transmission involves detachment of adhering bacteria from a donor and adhesion to a receiver surface, controlled by the relative values of the adhesion forces exerted by both surfaces. We here relate staphylococcal adhesion, detachment and transmission to, from, and between smooth and nanopillared-Si surfaces with staphylococcal adhesion forces...
October 17, 2016: ACS Applied Materials & Interfaces
D Lelic, I W D Fischer, A E Olesen, C D Mørch, F G Arguissain, J A B Manresa, A Dahan, A M Drewes
Severe pain is often treated with opioids. Antidepressants that inhibit serotonin and norepinephrine reuptake (SNRI) have also shown a pain relieving effect, but for both SNRI and opioids the specific mode of action in humans remains vague. This study investigated how oxycodone and venlafaxine affect spinal and supraspinal pain processing. Twenty volunteers were included in this randomized cross-over study comparing five-day treatment with venlafaxine, oxycodone and placebo. As a proxy of the spinal pain transmission, the nociceptive withdrawal reflex (NWR) to electrical stimulation on the sole of the foot was recorded at the tibialis anterior muscle before and after five days of treatment...
October 17, 2016: European Journal of Neuroscience
Élizabeth Lalande, Chantal Guimont, Marcel Émond, Marc Charles Parent, Claude Topping, Brice Lionel Batomen Kuimi, Valérie Boucher, Natalie Le Sage
OBJECTIVES: The main objective of this study was to evaluate the feasibility of emergency department (ED) point-of-care ultrasound (PoCUS) for rib fracture diagnosis in patients with minor thoracic injury (mTI). Secondary objectives were to 1) evaluate patients' pain during the PoCUS procedure, 2) identify the limitations of the use of PoCUS technique, and 3) compare the diagnosis obtained with PoCUS to radiography results. METHODS: Adult patients who presented with clinical suspicion of rib fractures after mTI were included...
October 17, 2016: CJEM
Julio C López-Doval, Cassiana C Montagner, Anjaína Fernandes de Alburquerque, Viviane Moschini-Carlos, Gisela Umbuzeiro, Marcelo Pompêo
Reservoirs located in urban areas suffer specific pressures related to human activities. Their monitoring, management, and protection requirements differ from reservoirs situated in non-urbanized areas. The objectives of this study were: (a) to determine the concentrations of select pesticides and emerging pollutants (EPs) present in an urban reservoir; (b) to describe their possible spatial distributions; and (c) to quantify the risks for aquatic life and safeguard drinking water supplies. For this purpose, the Guarapiranga reservoir was studied as an example of a multi-stressed urban reservoir in a tropical region...
October 13, 2016: Science of the Total Environment
Naoya Uchida, Juan J Haro-Mora, Atsushi Fujita, Duck-Yeon Lee, Thomas Winkler, Matthew M Hsieh, John F Tisdale
Human embryonic stem (ES) cells and induced pluripotent stem (iPS) cells represent an ideal source for in vitro modeling of erythropoiesis and a potential alternative source for red blood cell transfusions. However, iPS cell-derived erythroid cells predominantly produce ε- and γ-globin without β-globin production. We recently demonstrated that ES cell-derived sacs (ES sacs), known to express hemangioblast markers, allow for efficient erythroid cell generation with β-globin production. In this study, we generated several iPS cell lines derived from bone marrow stromal cells (MSCs) and peripheral blood erythroid progenitors (EPs) from sickle cell disease patients, and evaluated hematopoietic stem/progenitor cell (HSPC) generation after iPS sac induction as well as subsequent erythroid differentiation...
October 14, 2016: Stem Cells
Ganiyu Oladunjoye Oyetibo, Keisuke Miyauchi, Hitoshi Suzuki, Ginro Endo
Ecotoxicological implications of mercury (Hg) pollution of hydrosphere require effective Hg-removal strategies as antidote to the environmental problems. Mercury-tolerant yeasts, Yarrowia spp. Idd1 and Idd2 strains, were studied for intracellular accumulation and extracellular micro-precipitation of Hg during growth stage of the yeast strains. In a liquid medium containing 870 (±23.6) µg of bioavailable Hg(2+), 419.0 µg Hg(2+) (approx.) was taken up by the wet biomasses of the yeast strains after 48 h post-inoculation...
December 2016: AMB Express
S-H Zhang, P-Y Xu, J-J Chang
The algal growth and physiological characters of Aphanizomenon flos-aquae were studied under the stress of Sagittaria sagittifolia extract. The results showed that the growth of A. flos-aquae was significantly inhibited by S. sagittifolia extract. The exopolysaccharide (EPS), total soluble protein, intracellular phosphorus (o-PO4-P) contents and malondialdehyde (MDA) contents in A. flos-aquae cells increased significantly. These results suggested that A. flos-aquae can adapt to stress by increasing its normal metabolic activity...
October 13, 2016: Bulletin of Environmental Contamination and Toxicology
Jingjing Zhao, Zheng You
This work introduces three rectangular quasi-flat-top spots, which are provided by binary optical elements (BOEs) and utilized for the illumination in a microflow cytometer. The three spots contain, respectively, one, two, and three rectangles (R1, R2, and R3). To test the performance of this mechanism, a microflow cytometer is established by integrating the BOEs and a three-dimensional hydrodynamic focusing chip. Through the experiments of detecting fluorescence microbeads, the three spots present good fluorescence coefficients of variation in comparison with those derived from commercial instruments...
September 2016: Biomicrofluidics
Christian Wissgott, Wolfram Schmidt, Christoph Brandt-Wunderlich, Peter Behrens, Reimer Andresen
PURPOSE: To report early clinical outcomes with a novel double-layer stent for the internal carotid artery (ICA) and the in vitro investigation of the stent's mechanical properties. METHODS: A prospective single-center study enrolled 30 consecutive patients (mean age 73.1±6.3 years; 21 men) with symptomatic (n=25) or high-grade (n=5) ICA stenosis treated with the new double-layer carotid CGUARD Embolic Prevention System (EPS) stent, which has an inner open-cell nitinol design with an outer closed-cell polyethylene terephthalate layer...
October 12, 2016: Journal of Endovascular Therapy
Xin Zhang, Chuan-Wang Yang, Han-Qing Yu, Guo-Ping Sheng
Microbial extracellular polymeric substances (EPS) widely exist in natural environments and affect the migration and transformation of pollutants in aquatic environments. Previous works report that EPS have some reducing functional groups and can reduce heavy metals. However, because of the weak reducing capability of EPS, the reduction of heavy metals by EPS without cells is extremely slow, and its effect on heavy metals species is insignificant. In this work, the accelerated reduction of silver ions (Ag(+)) by EPS from Shewanella oneidensis MR-1 under illumination was investigated...
October 5, 2016: Water Research
Joseph Hufton, John H Harding, Maria E Romero-González
Bacterial extra polymeric substances (EPS) have been associated with the extracellular precipitation of uranium. Here we report findings on the biomineralisation of uranium, with extracellular DNA (eDNA) used as a model biomolecule representative of EPS. The complexation and precipitation of eDNA with uranium were investigated as a function of pH, ionic strength and varying concentrations of reactants. The role of phosphate moieties in the biomineralisation mechanism was studied by enzymatically releasing phosphate (ePO4) from eDNA compared to abiotic phosphate (aPO4)...
October 11, 2016: Physical Chemistry Chemical Physics: PCCP
Alexandre Minetto Brabo, Nayrana Soares Do Carmo Reis, Pasqual Barretti, Daniela Ponce
Encapsulating peritoneal sclerosis (EPS) is a rare complication of peritoneal dialysis that carries a high morbidity and mortality. Although its pathogenesis is still not clear, the "two hit theory" suggests that long term deterioration of the peritoneum combined with intraperitoneal inflammation is needed in the pathogenesis of EPS. To date, there is no proven effective therapy with an absence of randomized controlled trials. Individual case reports and small case series have reported on the use of tamoxifen and corticosteroids for medical management of EPS...
October 9, 2016: Hemodialysis International
Tahere Sadat Kalantarian, Iraj Najafi
After 20 years of peritoneal dialysis in Iran, we have encountered with several cases of encapsulating peritoneal sclerosis (EPS) in past few years. Many of these cases remained undiagnosed until advanced stages due to lack of suspicion. In centers with more experience about EPS, mortality has decreased by early diagnostic interventions. Peritoneal dialysis nurses may not be aware of EPS and radiologists are usually not familiar with EPS, either. To increase knowledge about this condition, we decided to present this review article with the case study of one of the 1st patients with EPS at our center...
September 2016: Iranian Journal of Kidney Diseases
Ramanathan Srinivasan, Kannan Rama Devi, Arunachalam Kannappan, Shunmugiah Karutha Pandian, Arumugam Veera Ravi
ETHNOPHARMACOLOGICAL RELEVANCE: Piper betle, a tropical creeper plant belongs to the family Piperaceae. The leaves of this plant have been well known for their therapeutic, religious and ceremonial value in South and Southeast Asia. It has also been reported to possess several biological activities including antimicrobial, antioxidant, antinociceptive, antidiabetic, insecticidal and gastroprotective activities and used as a common ingredient in indigenous medicines. In Indian system of ayurvedic medicine, P...
October 6, 2016: Journal of Ethnopharmacology
Dong Zheng, Qingbo Chang, Zhiwei Li, Mengchun Gao, Zonglian She, Xuejiao Wang, Liang Guo, Yangguo Zhao, Chunji Jin, Feng Gao
The performance and microbial community of a sequencing batch biofilm reactor (SBBR) treating synthetic mariculture wastewater were evaluated under long-term exposure to norfloxacin (NFX) due to the overuse of antibiotics during the mariculture. The COD and NH4(+)-N removals had no distinct change at 0-6mgL(-1) NFX and were inhibited at 6-35mgL(-1) NFX. The specific oxygen uptake rate (SOUR), specific ammonium oxidation rate (SAOR), specific nitrite oxidation rate (SNOR) and specific nitrate reduction rate (SNRR) of the biofilm kept a decreasing tendency with the increase of NFX concentration from 0 to 35mgL(-1)...
September 30, 2016: Bioresource Technology
Julia U Brandt, Frank Jakob, Jürgen Behr, Andreas J Geissler, Rudi F Vogel
BACKGROUND: Acetic acid bacteria (AAB) are well known producers of commercially used exopolysaccharides, such as cellulose and levan. Kozakia (K.) baliensis is a relatively new member of AAB, which produces ultra-high molecular weight levan from sucrose. Throughout cultivation of two K. baliensis strains (DSM 14400, NBRC 16680) on sucrose-deficient media, we found that both strains still produce high amounts of mucous, water-soluble substances from mannitol and glycerol as (main) carbon sources...
October 4, 2016: Microbial Cell Factories
Travis T Wager, Thomas A Chappie, David Horton, Ramalakshmi Y Chandrasekaran, Brian M Samas, Elizabeth Dunn-Sims, Cathleen Hsu, Nawshaba Nawreen, Michelle A Vanase-Frawley, Rebecca E O'Connor, Christopher Schmidt, Keith Dlugolenski, Nancy C Stratman, Mark J Majchrzak, Bethany L Kormos, David Nguyen, Aarti Sawant-Basak, Andy N Mead
Dopamine receptor antagonism is a compelling molecular target for the treatment of a range of psychiatric disorders, including substance use disorders. From our corporate compound file we identified a structurally unique D3 receptor (D3R) antagonist scaffold, 1. Through a hybrid approach, we merged key pharmacophore elements from 1 and D3 agonist 2 to yield the novel D3R/D2R antagonist PF-4363467 (3). Compound 3 was designed to possess CNS drug-like properties as defined by its CNS MPO desirability score (≥4/6)...
October 7, 2016: ACS Chemical Neuroscience
Yuanzhao Ding, Yufan Zhou, Juan Yao, Craig Szymanski, James K Fredrickson, Liang Shi, Bin Cao, Zihua Zhu, Xiao-Ying Yu
Molecular mapping of live biofilms at submicron resolution presents a grand challenge. Here, we present the first chemical mapping results of biofilm extracellular polymeric substance (EPS) components in biofilms using correlative imaging be-tween super resolution florescence microscopy and liquid time-of-flight secondary ion mass spectrometry (ToF-SIMS). She-wanella oneidensis is used as a model organism. Heavy metal anions chromate (Cr2O72-) consisting of chromium Cr (VI) was a model environmental stressor used to treat the biofilms...
October 6, 2016: Analytical Chemistry
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