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https://www.readbyqxmd.com/read/28213514/peripheral-membrane-interactions-boost-the-engagement-by-an-anti-hiv-1-broadly-neutralizing-antibody
#1
Edurne Rujas, José M M Caaveiro, Sara Insausti, Miguel García-Porras, Kouhei Tsumoto, José L Nieva
The 4E10 antibody displays an extreme breadth of HIV-1 neutralization and therefore constitutes a suitable model system for structure- guided vaccine design and immunotherapeutics against AIDS. In this regard, the relevance of auto- reactivity with membrane lipids for the biological function of this antibody is still a subject of controversy. To address this dispute, herein we have compared the membrane-partitioning ability of the 4E10 antibody and several of its variants, which were mutated at the region of the paratope surface in contact with the membrane-interface...
February 17, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28213164/carvedilol-use-is-associated-with-improved-survival-in-patients-with-liver-cirrhosis-and-ascites
#2
Rohit Sinha, Khalida A Lockman, Nethmee Mallawaarachchi, Marcus Robertson, John N Plevris, Peter C Hayes
BACKGROUND AND AIMS: Carvedilol, a non-selective beta-blocker (NSBB) with additional anti-alpha 1 receptor activity, is a potent portal hypotensive agent. It has been used as prophylaxis against variceal bleed. However, its safety in decompensated liver cirrhosis with ascites is still disputed. In this study, we examined whether long-term use of carvedilol in the presence of ascites is a risk factor for mortality. METHODS: This was a single-centre retrospective analysis of 325 consecutive patients with liver cirrhosis and ascites presenting to our Liver Unit between 1(st) of January 2009 to 31(st) August 2012...
February 14, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28209178/tumor-initiating-cells-a-critical-review-of-isolation-approaches-and-new-challenges-in-targeting-strategies
#3
REVIEW
Komal Qureshi-Baig, Pit Ullmann, Serge Haan, Elisabeth Letellier
Most cancers contain a subpopulation of highly tumorigenic cells, known as cancer stem cells (CSCs) or tumor-initiating cells (TICs). Targeting TICs may be essential to achieve cure, because of their self-renewal and tumorigenic properties as well as their resistance to conventional therapies. Despite significant advances in TIC biology, their isolation and identification remain largely disputed and incompletely established. In this review, we discuss the latest developments in isolation and culturing approaches of TICs, with focus on colorectal cancer (CRC)...
February 16, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/28207572/cross-reactivity-of-chloroquine-and-hydroxychloroquine-with-dri-amphetamine-immunoassay
#4
Isabel Gomila, Loreto Quesada, Victoria López-Corominas, Julia Fernández, Miguel Ángel Servera, Laura Sahuquillo, Macarena Dastis, Albert Torrents, Bernardino Barceló
BACKGROUND: Chloroquine and hydroxychloroquine are medical drugs used to treat the chemoprophylaxis of malaria as well as a second-line anti-inflammatory drug. METHODS: We performed a study of cross-reactivity of chloroquine and hydroxychloroquine in the DRI Amphetamine Assay inspired by a case report of a self-ingestion of chloroquine following a family dispute, that involved the following: (a) an in vitro study with control samples of healthy subjects, (b) an in vivo study with samples of patients with rheumatoid arthritis, and (c) an evaluation of the cross-reactivity of chloroquine and hydroxychloroquine in three additional immunoassays...
February 14, 2017: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/28205207/home-uterine-monitoring-for-detecting-preterm-labour
#5
REVIEW
Christine Urquhart, Rosemary Currell, Francoise Harlow, Liz Callow
BACKGROUND: To reduce the morbidity and mortality associated with preterm birth, home uterine activity monitoring aims for early detection of increased contraction frequency, and early intervention with tocolytic drugs to inhibit labour and prolong pregnancy. However, the effectiveness of such monitoring is disputed. OBJECTIVES: To determine whether home uterine activity monitoring is effective in improving the outcomes for women and their infants considered to be at high risk of preterm birth, when compared with care that does not include home uterine activity monitoring...
February 15, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28205090/-from-controversy-to-scientific-discussion-the-dispute-over-the-vacuum-and-its-pascalian-metamorphosis
#6
Martine Pécharman
Pascal's Expériences nouvelles touchant le vide (1647) outlines a physical demonstration that aims to put to an end controversies between plenists and vacuists. The traditional form of the dispute with which Pascal wanted to break, however, finds itself reactivated by Étienne Noël, who takes up again the plenist objections which the Expériences nouvelles only consider as possible the better to refute them. Pascal's letters Au très révérend père Noël and À Monsieur Le Pailleur on the contrary permit one to define a field of disputation different from the one which Noël perpetuates...
December 2016: Revue de Synthèse
https://www.readbyqxmd.com/read/28205089/-margaret-cavendish-vs-robert-hooke-an-impossible-duel
#7
Frédérique Aït-Touati
In 1665, Robert Hooke published his major work in microscopy, Micrographia, a defense of experimental philosophy. The following year, Margaret Cavendish, Duchess of Newcastle, published at her own expense a treatise and a novel that undermined the basis of this new science. The dispute broke out at the initiative of the Duchess, in the context of a vast controversy about the legitimacy and the efficiency of optical instruments in natural philosophy. All the figures of the dual are used, except one: the counterattack...
December 2016: Revue de Synthèse
https://www.readbyqxmd.com/read/28205088/-%C3%A2-what-is-the-best-theory-of-generation-%C3%A2-arguments-and-debates-among-students-from-the-royal-medical-society-in-eighteenth-century-edinburgh
#8
Sophie Vasset
This article proposes a different approach to the long generation controversy that divided naturalists in eighteenth-century Europe between those in favour of preformationism, on the one hand, and supporters of the theory of epigenesis on the other. This controversy has mostly been studied through the publications of the intellectual elite, that was constituted of medical doctors, natural historians, philosophers, and theologians. Rather than reviewing the ideas and antagonisms of the direct agents of the controversy, I will attempt to approach it from the margins...
December 2016: Revue de Synthèse
https://www.readbyqxmd.com/read/28202379/comprehensive-preoperative-work-up-and-surgical-treatment-of-low-grade-tumor-benign-lesion-related-temporal-lobe-epilepsy
#9
Rui Feng, Jie Hu, Jinsong Wu, Liqin Lang, Chengxin Ma, Shize Jiang, Bing Sun, Xin Gu, Li Pan
OBJECTIVE: Generally low-grade tumor/benign lesion related temporal lobe epilepsy (LGT/BL-TLE) is considered easier to treat and has better prognosis when compared to non-lesional TLE. However, multiple disputes exist in surgical management of this epilepsy entity. This study aims to discuss comprehensive preoperative work-up, surgical strategies and outcome of it. METHODS: A retrospective review of sixty LGT/BL-TLE cases which underwent comprehensive preoperative work-up and then resective surgeries was conducted...
February 12, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28198936/-eugenics-and-immigration-selection-notes-on-the-debate-between-alfredo-ellis-junior-oliveira-vianna-and-menotti-del-picchia-1926
#10
Lorenna Ribeiro Zem El-Dine
This text analyzes the bill submitted by Alfredo Ellis Junior to the São Paulo legislature in August 1926, which would allow studies to be made of immigrants in São Paulo in order to orient immigration selection policies. It highlights the opinions of Menotti Del Picchia and Oliveira Vianna about the research agenda put forward by Alfredo Ellis Junior, focusing on the different conceptions about the race issue and immigration held in the 1920s. We suggest that Menotti Del Picchia's divergence from Alfredo Ellis Junior and Oliveira Vianna could be interpreted as a dispute between literati and scientists over the legitimacy of their respective knowledge about the Brazilian reality and the proposal of policies for the country...
December 2016: História, Ciências, Saúde—Manguinhos
https://www.readbyqxmd.com/read/28195907/solitary-psma-positive-pulmonary-metastasis-in-biochemical-relapse-of-prostate-cancer
#11
Nils Groe Hokamp, Carsten Kobe, Eric Linzenich, David Maintz, Alexander Drzezga
A 63-year-old man with a history of prostate cancer, treated with resection, radiation, and androgen-depriving therapy over 4 years, was referred to our department with suspicion of recurrence based on increased blood PSA levels (1.60 ng/mL). Ga PSMA PET/CT identified a solitary, PSMA-positive pulmonary nodule in the right lung. After resection, histologic analysis confirmed prostatic origin, and the blood PSA level decreased to 0.13 ng/mL. Solitary pulmonary metastasis from prostate cancer is rare. The benefits of local treatment of a single metastasis even in advanced disease are disputed among oncologists...
February 13, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28195025/the-depth-of-fields-managing-focus-in-the-epistemic-subcultures-of-mind-and-brain-science
#12
David Peterson
The 'psy' sciences emerged from the tangled roots of philosophy, physiology, biology and medicine, and these origins have produced heterogeneous fields. Scientists in these areas work in a complex, overlapping ecology of fields that results in the constant co-presence of dissonant theories, methods and research objects. This raises questions regarding how conceptual clarity is maintained. Using the optical metaphor 'depth of field', I show how researchers in all fields marginalize potential threats to routine scientific work by framing them as either too broad and imprecise or too narrow and technical...
February 2017: Social Studies of Science
https://www.readbyqxmd.com/read/28192384/lucae-s-springy-pressure-probe-to-mobilize-the-ossicular-chain-rise-and-fall-of-an-ingenious-instrument
#13
Rinze Anthony Tange, Albert Mudry
OBJECTIVES/HYPOTHESES: In 1884, Johann Constantin August Lucae (1835-1911), a German otologist from Berlin, introduced a new "method to mechanically treat chronic troubles of the mobility of the hearing organ transmission apparatus." It consisted in the use of a springy pressure probe to directly mobilize the handle of the malleus. The aim of this study is to trace the invention, clinical use, technological modifications, and ultimate extinction of this instrument. METHOD: Review of Lucae's publications, comments by his colleagues, and trade catalogues published between 1880 and 1940...
March 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28187361/toxicity-of-abamectin-and-difenoconazole-mixtures-to-a-neotropical-cladoceran-after-simulated-run-off-and-spray-drift-exposure
#14
Raquel Aparecida Moreira, Michiel Adriaan Daam, Bruna Horvath Vieira, Ana Letícia Madeira Sanches, Marina Vanderlei Reghini, Adrislaine da Silva Mansano, Emanuela Cristina de Freitas, Evaldo Luiz Gaeta Espindola, Odete Rocha
Aquatic risk assessments of pesticides in tropical countries have often been disputed for being largely based on risk evaluations conducted in temperate regions. Although pesticide sensitivity comparisons between temperate and tropical freshwater organisms have indeed not revealed consistent differences, risk assessments are currently still based on a relatively small tropical toxicity dataset. In addition, greater levels of runoff and spray drift may be expected in tropical than in temperate agroecosystems, indicating that aquatic life in edge-of-field water bodies is likely to be subjected to higher concentrations of pesticides and their mixtures...
February 3, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28187024/residual-symptom-analysis-after-the-subtotal-anterior-and-middle-scalenectomy-for-disputed-thoracic-outlet-syndrome-comparison-between-surgical-and-untreated-patients
#15
Xu Gong, Zhen Min Jiang, Lai Jin Lu
OBJECTIVE: There are significant differences in the results on disputed thoracic outlet syndrome (TOS) surgery, which reflect that not all patients with disputed TOS are amenable to surgery. It is necessary to find out appropriate indicators for screening of patients who are suitable for surgery. Pain and paresthesia are 2 prominent symptoms of disputed TOS. The purpose of this study was to identify which symptoms could be removed by surgery. METHODS: Data for all patients with disputed TOS who were admitted and prepared for surgical treatment between July 2008 and April 2012 were collected...
February 10, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28183452/controversies-in-the-management-of-hyperglycaemic-emergencies-in-adults-with-diabetes
#16
REVIEW
Luís Cardoso, Nuno Vicente, Dírcea Rodrigues, Leonor Gomes, Francisco Carrilho
Hyperglycaemic emergencies are associated with significant morbi-mortality and healthcare costs. Management consists on fluid replacement, insulin therapy, and electrolyte correction. However, some areas of patient management remain debatable. In patients without respiratory failure or haemodynamic instability, arterial and venous pH and bicarbonate measurements are comparable. Fluid choice varies upon replenishment phase and patient's condition. If patient is severely hypovolaemic, normal saline solution should be the first option...
March 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28174158/junior-doctor-dispute-may-have-lasting-impact-on-nhs-researchers-say
#17
Matthew Limb
No abstract text is available yet for this article.
February 7, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28168846/performance-of-honey-bee-colonies-under-a-long-lasting-dietary-exposure-to-sub-lethal-concentrations-of-the-neonicotinoid-insecticide-thiacloprid
#18
Reinhold Siede, Lena Faust, Marina D Meixner, Christian Maus, Bernd Grünewald, Ralph Büchler
BACKGROUND: Substantial honey bee colony losses have occurred periodically in the last decades. The drivers for these losses are not fully understood. The influence of pests and pathogens are beyond dispute, but in addition, chronic exposure to sub-lethal concentrations of pesticides has been suggested to affect the performance of honey bee colonies. This study aims to elucidate the potential effects of a chronic exposure to sub-lethal concentrations (one realistic worst-case concentration) of the neonicotinoid thiacloprid to honey bee colonies in a three-year replicated colony feeding study...
February 7, 2017: Pest Management Science
https://www.readbyqxmd.com/read/28166659/a-study-on-the-reporting-intention-of-medical-incidents
#19
Li-Chin Chen, Li-Hsiang Wang, Bernice Redley, Ya-Hui Hsieh, Tsung-Lan Chu, Chin-Yen Han
Medical incidents threaten patients' lives and health, increase medical costs, and can lead to medical disputes. A high proportion of medical incidents are not reported. The aim of this study was to explore the factors influencing nurses' reporting of medical incidents. The cross-sectional survey design used a self-administered 47-item questionnaire to survey 835 nurses in three hospitals in Taiwan between January and December 2014. The intention among nurses to report medical incidents was high (3.86/5); nurses' intention to report medical incidents was positively correlated ( r = ...
February 1, 2017: Clinical Nursing Research
https://www.readbyqxmd.com/read/28154049/bringing-probability-judgments-into-policy-debates-via-forecasting-tournaments
#20
REVIEW
Philip E Tetlock, Barbara A Mellers, J Peter Scoblic
Political debates often suffer from vague-verbiage predictions that make it difficult to assess accuracy and improve policy. A tournament sponsored by the U.S. intelligence community revealed ways in which forecasters can better use probability estimates to make predictions-even for seemingly "unique" events-and showed that tournaments are a useful tool for generating knowledge. Drawing on the literature about the effects of accountability, the authors suggest that tournaments may hold even greater potential as tools for depolarizing political debates and resolving policy disputes...
February 3, 2017: Science
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