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https://www.readbyqxmd.com/read/29778230/etv6-runx1-positive-childhood-acute-lymphoblastic-leukemia-all-the-spectrum-of-clonal-heterogeneity-and-its-impact-on-prognosis
#1
Μ Αmpatzidou, S I Papadhimitriou, G Paterakis, D Pavlidis, Κ Tsitsikas, I V Kostopoulos, V Papadakis, G Vassilopoulos, S Polychronopoulou
The prognostic significance of the ETV6/RUNX1-fusion and of the accompanying aberrations is disputable; whether co-existing sub-clones are responsible for delayed MRD-clearance and thus, moderate outcome, remains to be clarified. We studied, in a paediatric cohort of 119 B-ALLs, the relation between the ETV6/RUNX1 aberration and the co-existing subclones with (a) presenting clinical/biological features, (b) early response to treatment(MRD) and (c) long-term outcome over a 12-year period. Patients were homogeneously treated according to BFM-based-protocols...
August 2018: Cancer Genetics
https://www.readbyqxmd.com/read/29775975/misleading-new-insights-into-the-chrysotile-debate
#2
H-J Woitowitz, X Baur
Although there is no dispute among independent scientists about the carcinogenic and fibrogenic effects of chrysotile, the asbestos industry has been continuously and successfully acting to cast doubts on its harm. Another approach including asbestos insurance entities is to refuse compensation by raising the bar and fight criminal prosecution for asbestos-related diseases by the help of paid scientists. A recent publication on asbestos fibre burden in human lungs fits well in this context. The claim that chrysotile fibres are biopersistent in human lung is not based on the data provided by these authors, and, additionally, exhibits serious inconsistencies and obvious mismeasurements and significant methodological problems...
May 18, 2018: Pneumologie
https://www.readbyqxmd.com/read/29773221/are-there-distinct-forms-of-accelerated-forgetting-and-if-so-why
#3
Andrew R Mayes, Nicola M Hunkin, Claire Isaac, Nils Muhlert
Whether accelerated long-term forgetting (ALF) and classic organic amnesia, particularly hippocampal-amnesia, differ qualitatively or merely quantitatively is disputed. Qualitative difference accounts postulate that ALF patients show normal recall memory for at least minutes, during which hippocampal-amnesics already show accelerated forgetting and impaired recall but, thereafter, ALF patients show accelerated forgetting and impaired delayed recall. These delayed impairments may be more severe than those shown by hippocampal-amnesics...
April 19, 2018: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/29770733/the-relationship-between-mirror-touch-synaesthesia-and-empathy-new-evidence-and-a-new-screening-tool
#4
Jamie Ward, Patricia Schnakenberg, Michael J Banissy
People with mirror-touch synaesthesia (MTS) report tactile sensations on their own body when seeing another person being touched. Although this has been associated with heightened empathy and emotion perception, this finding has been disputed. Here, we conduct two experiments to explore this relationship further. In Experiment 1, we develop a new screening measure for MTS. We show that MTS is related to vicarious experiences more generally, but is not a simple exaggerated version of normality. For example, people with MTS report videos of scratching as "touch" rather than "itchiness" and have localized sensations when watching others in pain...
May 17, 2018: Cognitive Neuropsychology
https://www.readbyqxmd.com/read/29769634/in-vitro-generation-of-panton-valentine-leukocidin-pvl-in-clinical-methicillin-resistant-staphylococcus-aureus-mrsa-and-its-correlation-with-pvl-variant-clonal-complex-infection-type
#5
Chuanling Zhang, Yuanyu Guo, Xu Chu
The amount of Panton-Valentine leukocidin (PVL) is diverse among Staphylococcus aureus isolates from different geographical regions, and its significance in some infections is disputed. However, data concerning this information in China are limited. Fifty-one lukSF-PV+ methicillin-resistant Staphylococcus aureus (MRSA) isolates gathered from varying infections were used for PVL production using enzyme-linked immunosorbent assay, and the quantity was analyzed in correlation with PVL isoform, genetic background of the isolate, and disease category...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29768991/mediating-justice-women-s-perceptions-of-fairness-in-the-civil-protection-order-process
#6
M Kristen Hefner, Aneesa A Baboolal, Ruth E Fleury-Steiner, Susan L Miller
Mediation use has grown rapidly in the past few decades as an efficacious method of civil dispute resolution. However, early research suggests that civil mediation may cause further harm to victims of intimate partner abuse because, based on the inherent power dynamics of abusive relationships, they are not able to effectively advocate on their own behalf. In addition, organizational efficiency concerns have led to the development of consent processes for civil protection orders (POs). However, research has yet to examine the extent to which victims of intimate partner violence who take part in these consent processes perceive the process and associated outcomes as fair...
May 1, 2018: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29768334/a-case-report-of-b-lymphoblastic-lymphoma-with-brain-metastases-clinical-and-pathological-significance-of-head-trauma-misdiagnosis
#7
Jian Shi, Jale Manzo, Yiwu Zhou, Peter Agovino, Song Wu
INTRODUCTION: B lymphoblastic lymphoma (B-LBL) is a rare type of lymphoma that originates from precursor lymphocytes. B-BLB in adults with brain metastases is extremely rare as the disease mainly affects children and adults. Therefore, such a seldom-seen case can easily trigger a dispute regarding clinical diagnosis and treatment.This paper reports the case of a 22-year-old man hospitalized for a head injury that resulted from a physical altercation. Upon admission to the hospital, the patient was diagnosed with a diffuse axonal injury (DAI)...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29767825/-palliative-sedation-development-and-consensus-of-a-german-language-documentation-template
#8
C Klein, C Wittmann, K N Wendt, C Ostgathe, S Stiel
BACKGROUND: Palliative sedation (PS) serves as a therapeutic option in cases of otherwise intractable suffering. As the use of sedative and hypnotic medication in many diverse situations is a core competency of anesthesiology, anesthesiologists are confronted with questions of sedative therapy at the end of life in institutions for specialized palliative care, in intensive care units and intermediate care wards. In recent years a number of guidelines have been published internationally but so far no official guidelines exist in Germany...
May 16, 2018: Der Anaesthesist
https://www.readbyqxmd.com/read/29760948/the-diagnosis-and-treatment-of-primary-vitreoretinal-lymphoma-a-review
#9
REVIEW
Jose S Pulido, Patrick B Johnston, Grzegorz S Nowakowski, Allessia Castellino, Harish Raja
Background: To describe the recent diagnostic and treatment options for the most predominant form of primary vitreoretinal lymphoma (PVRL), namely diffuse large B cell lymphoma. This is mainly based on the experience at the Mayo Clinic as well as a partial review of the literature. MYD88 L265P mutation is seen in about 80% of cases; therefore, a polymerase chain reaction for this mutation helps in making the diagnosis that has been notoriously difficult to make. Local therapy using intravitreal methotrexate and rituximab has been very helpful in the treatment of the local disease...
2018: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/29760297/follicular-hyperandrogenism-and-insulin-resistance-in-polycystic-ovary-syndrome-patients-with-normal-circulating-testosterone-levels
#10
Andi Li, Lu Zhang, Jiajia Jiang, Nan Yang, Ying Liu, Lingbo Cai, Yugui Cui, Feiyang Diao, Xiao Han, Jiayin Liu, Yujie Sun
Polycystic ovary syndrome (PCOS) is a common reproductive disease with high heterogeneity. The role of excess androgen in PCOS etiology remains disputed, since around 20%-50% of PCOS women do not display hyperandrogenemia. The microenvironment of the ovary critically influences follicular development. In the present study, we assessed the role of androgen in PCOS by investigating whether excessive follicular fluid androgen was present in PCOS patients with normal serum androgen levels and influenced by follicular fluid insulin resistance (IR)...
November 1, 2017: Journal of Biomedical Research
https://www.readbyqxmd.com/read/29756519/adipose-derived-stem-cells-stimulated-with-n-butylidenephthalide-exhibit-therapeutic-effects-in-a-mouse-model-of-parkinson-s-disease
#11
Kang Chi, Ru-Huei Fu, Yu-Chuen Huang, Shih-Yin Chen, Ching-Ju Hsu, Shinn-Zong Lin, Chi-Tang Tu, Li-Hsun Chang, Ping-An Wu, Shih-Ping Liu
Parkinson's disease (PD) causes motor dysfunction and dopaminergic cell death. Drug treatments can effectively reduce symptoms but often cause unwanted side effects. Stem cell therapies using cell replacement or indirect beneficial secretomes have recently emerged as potential therapeutic strategies. Although various types of stem cells have been proposed as possible candidates, adipose-derived stem cells (ADSCs) are easily obtainable, more abundant, less ethically disputed, and able to differentiate into multiple cell lineages...
January 1, 2018: Cell Transplantation
https://www.readbyqxmd.com/read/29752340/long-non-coding-rna-xist-predicts-worse-prognosis-in-digestive-system-tumors-a-systemic-review-and-meta-analysis
#12
Xuefang Liu, Xinliang Ming, Wei Jing, Ping Luo, Nandi Li, Man Zhu, Mingxia Yu, Chunzi Liang, Jiancheng Tu
Aims: Increasing studies are indicating that long non-coding RNA X-inactive specific transcript (XIST) is associated with the prognosis of cancer patients. However, the results have been disputed. Therefore, we aimed to further explore the prognostic value and clinical significance of XIST in various types of cancers. Then, we focused our research on the comparison of the predictive value of XIST between digestive system tumors and non-digestive system tumors. Methods: We performed a systematic search by looking up PubMed, Embase, Cochrane Library, Web of Science, and Medline (up to January 3, 2018)...
May 11, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29750171/phylogeny-of-maleae-rosaceae-based-on-multiple-chloroplast-regions-implications-to-genera-circumscription
#13
Jiahui Sun, Shuo Shi, Jinlu Li, Jing Yu, Ling Wang, Xueying Yang, Ling Guo, Shiliang Zhou
Maleae consists of economically and ecologically important plants. However, there are considerable disputes on generic circumscription due to the lack of a reliable phylogeny at generic level. In this study, molecular phylogeny of 35 generally accepted genera in Maleae is established using 15 chloroplast regions. Gillenia is the most basal clade of Maleae, followed by Kageneckia + Lindleya , Vauquelinia , and a typical radiation clade, the core Maleae, suggesting that the proposal of four subtribes is reasonable...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29749042/miscommunication-in-doctor-patient-communication
#14
Rose McCabe, Patrick G T Healey
The effectiveness of medical treatment depends on the quality of the patient-clinician relationship. It has been proposed that this depends on the extent to which the patient and clinician build a shared understanding of illness and treatment. Here, we use the tools of conversation analysis (CA) to explore this idea in the context of psychiatric consultations. The CA "repair" framework provides an analysis of the processes people use to deal with problems in speaking, hearing, and understanding. These problems are especially critical in the treatment of psychosis where patients and health care professionals need to communicate about the disputed meaning of hallucinations and delusion...
April 2018: Topics in Cognitive Science
https://www.readbyqxmd.com/read/29748576/autophagy-diminishes-the-early-interferon-%C3%AE-response-to-influenza-a-virus-resulting-in-differential-expression-of-interferon-stimulated-genes
#15
Brieuc P Perot, Jeremy Boussier, Nader Yatim, Jeremy S Rossman, Molly A Ingersoll, Matthew L Albert
Influenza A virus (IAV) infection perturbs metabolic pathways such as autophagy, a stress-induced catabolic pathway that crosstalks with cellular inflammatory responses. However, the impact of autophagy perturbation on IAV gene expression or host cell responses remains disputed. Discrepant results may be a reflection of in vivo studies using cell-specific autophagy-related (Atg) gene-deficient mouse strains, which do not delineate modification of developmental programmes from more proximal effects on inflammatory response...
May 10, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29746686/taking-respect-seriously-clinical-research-and-the-demands-of-informed-consent
#16
Lynn A Jansen
There is broad agreement among research ethicists that investigators have a duty to obtain the informed consent of all subjects who participate in their research trials. On a common view, the duty to obtain this informed consent follows from the need to respect persons and their autonomous decisions. However, the nature of informed consent and the demands it places on investigators are open to dispute and recently have been challenged. Respect for persons, it has been claimed, does not require investigators to guarantee that the subjects enrolled in their trials comprehend the risk/benefit information disclosed to them or even that they appreciate the difference between research and therapy...
May 9, 2018: Journal of Medicine and Philosophy
https://www.readbyqxmd.com/read/29744475/microscopic-varicocelectomy-as-a-treatment-option-for-patients-with-severe-oligospermia
#17
Chirag Gupta, Arun Chinchole, Rupin Shah, Hemant Pathak, Deepa Talreja, Ankit Kayal
Purpose: Many studies have shown improved semen parameters after varicocele surgery; however, the benefit in terms of improved pregnancy rates and live births is still disputed in cases of severe oligoasthenozoospermia (OAS). The present study evaluated the outcome of microscopic subinguinal varicocelectomy in terms of the spontaneous pregnancy rate in patients with severe OAS. Materials and Methods: This was a retrospective, observational, analytic study of 56 men with OAS who underwent microscopic varicocelectomy at our center between 2008 and 2015...
May 2018: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/29743176/warfarin-and-vitamin-k-epoxide-reductase-a-molecular-accounting-for-observed-inhibition
#18
Sangwook Wu, Xuejie Chen, Da-Yun Jin, Darrel W Stafford, Lee G Pedersen, Jian-Ke Tie
Vitamin K epoxide reductase (VKOR), an endoplasmic reticulum membrane protein, is the key enzyme for vitamin K-dependent carboxylation, a post-translational modification that is essential for the biological functions of coagulation factors. VKOR is the target of the most widely prescribed oral anticoagulant warfarin. However, the topological structure of VKOR and the mechanism of warfarin's inhibition of VKOR remain elusive. Additionally, it is not clear why warfarin-resistant VKOR mutations identified in patients significantly decrease warfarin's binding affinity, but have only a minor effect on vitamin K binding...
May 9, 2018: Blood
https://www.readbyqxmd.com/read/29743065/rationing-cancer-treatment-a-qualitative-study-of-perceptions-of-legitimate-limit-setting
#19
Eli Feiring, Hege Wang
BACKGROUND: Governments are facing tough choices about whether to fund new, promising but highly expensive drugs within the public healthcare system. Decisions that some drugs are not sufficiently beneficial relative to their cost to merit public funding are often contentious. The importance of making decisions that stakeholders can understand and accept as legitimate is increasingly recognized and is commonly understood to be a crucial component for stakeholder support and successful implementation...
May 9, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29742858/long-term-outcome-of-a-fissurectomy-a-prospective-single-arm-study-of-50-operations-out-of-349-initial-patients
#20
Jean-David Zeitoun, Pierre Blanchard, Nadia Fathallah, Paul Benfredj, Nicolas Lemarchand, Vincent de Parades
PURPOSE: The surgical standard of care for patients with chronic anal fissure is still disputed. We aimed to assess the natural course of idiopathic anal fissure and the long-term outcome of a fissurectomy as a surgical treatment. METHODS: All consecutive patients referred to a single expert practitioner in a tertiary centre were primarily included. A fissurectomy was proposed in cases of refractory symptoms after 4 to 6 weeks of standard medical management. Only patients with idiopathic and noninfected anal fissures were included in this second subsample to undergo surgery...
April 2018: Annals of Coloproctology
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