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https://www.readbyqxmd.com/read/29150528/autophagy-in-the-context-of-the-cellular-membrane-trafficking-system-the-enigma-of-atg9-vesicles
#1
REVIEW
Takeshi Noda
Macroautophagy is an intracellular degradation system that involves the de novo formation of membrane structures called autophagosomes, although the detailed process by which membrane lipids are supplied during autophagosome formation is yet to be elucidated. Macroautophagy is thought to be associated with canonical membrane trafficking, but several mechanistic details are still missing. In this review, the current understanding and potential mechanisms by which membrane trafficking participates in macroautophagy are described, with a focus on the enigma of the membrane protein Atg9, for which the proximal mechanisms determining its movement are disputable, despite its key role in autophagosome formation...
November 17, 2017: Biochemical Society Transactions
https://www.readbyqxmd.com/read/29148326/understanding-professional-jurisdiction-changes-in-the-field-of-anesthesiology
#2
Scott Feyereisen, Joseph P Broschak, Beth Goodrick
We further our understanding of jurisdictional disputes between established professional groups through a 10-year longitudinal analysis of the differential adoption by U.S. states of policies expanding Certified Registered Nurse Anesthetists' (CRNAs) autonomy. In the United States, CRNAs are trained to deliver anesthetics to patients in the same way as physician anesthesiologists but have more restrictions in practice. Following a 2001 federal decision regarding Medicare reimbursement, states were permitted but not required to allow CRNAs to practice without physician supervision, potentially reducing health care costs...
January 1, 2017: Medical Care Research and Review: MCRR
https://www.readbyqxmd.com/read/29145757/nutrition-and-lower-extremity-ulcers-causality-and-or-treatment
#3
Lauren Haughey, Adrian Barbul
The association between malnutrition, impaired wound healing, and the presence of chronic wounds has been recognized for a long time. It is widely believed that the lack of adequate nutrition increases the risk of developing wounds which have a great likelihood of progressing to chronicity due to lack of appropriate healing responses. This risk is particularly high in the aging population. For the individual patient, as well as patient populations, the diagnosis of malnutrition has been in dispute; further, there is lack of agreement of when and how to intervene nutritionally in those with wounds or healing deficits...
November 1, 2017: International Journal of Lower Extremity Wounds
https://www.readbyqxmd.com/read/29143620/optimising-diagnosis-of-viraemic-hepatitis-c-infection-the-development-of-a-target-product-profile
#4
Elena Ivanova Reipold, Philippa Easterbrook, Alessandra Trianni, Nivedha Panneer, Douglas Krakower, Stefano Ongarello, Teri Roberts, Veronica Miller, Claudia Denkinger
BACKGROUND: The current low access to virological testing to confirm chronic viraemic HCV infection in low- and middle-income countries (LMIC) is limiting the rollout of hepatitis C (HCV) care. Existing tests are complex, costly and require sophisticated laboratory infrastructure. Diagnostic manufacturers need guidance on the optimal characteristics a virological test needs to have to ensure the greatest impact on HCV diagnosis and treatment in LMIC. Our objective was to develop a target product profile (TPP) for diagnosis of HCV viraemia using a global stakeholder consensus-based approach...
November 1, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29143500/-pulmonary-hypertension-and-pregnancy
#5
Eleni Diamanti, David Baud, John-David Aubert, Laurent P Nicod
Pregnancy in the context of pulmonary hypertension is characterised by high mortality for the mother and the foetus and is therefore strongly discouraged ; contraception has to be prescribed to patients in reproductive age. Women who decide to continue their pregnancy should be followed by multidisciplinary teams in specialised centres. A specific treatment should be defined with no delay. In case of clinical deterioration, the early, intravenous administration of prostacyclin should be considered. The ideal time and method of delivery are still disputed...
November 15, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29143237/john-henryism-gender-and-self-reported-health-among-roma-gypsies-in-serbia
#6
Jelena Čvorović, Sherman A James
We describe how self-reported health (SRH) varies with gender and John Henryism (a strong behavioral predisposition to engage in high-effort coping to overcome adversity) in a low income sample of Serbian Roma. Data were collected in 2016 in several Roma settlements around Belgrade, Serbia. The sample consisted of 90 men and 112 women. In addition to John Henryism (JH), measured by a Serbian version of the John Henryism Scale, demographic data and data on SRH and family relationships dynamics were collected...
November 15, 2017: Culture, Medicine and Psychiatry
https://www.readbyqxmd.com/read/29129696/the-making-of-a-mushroom-mitosis-nuclear-migration-and-the-actin-network
#7
Elke-Martina Jung, Erika Kothe, Marjatta Raudaskoski
Basidiomycetes feature a prolonged dikaryotic life stage. A dispute over open versus closed mitosis could be solved using in vivo fluorescence videomicroscopy of histone 2B::EGFP and Lifeact labeled Schizophyllum commune. It revealed nuclei to condense to approximately one fifth in diameter during mitotic prophase. In addition, the specifics of clamp cell formation typical of many basidiomycetes included an actin network at the future site of nuclear division, which allowed for cessation of nuclear movement and re-localization of one nucleus towards the emerging clamp cell, while the other divided along the hyphal axis...
November 9, 2017: Fungal Genetics and Biology: FG & B
https://www.readbyqxmd.com/read/29128653/acoustic-environment-identification-by-kullback-leibler-divergence
#8
G Delgado-Gutiérrez, F Rodríguez-Santos, O Jiménez-Ramírez, R Vázquez-Medina
This paper presents a forensic methodology that determines, from among a set of recording places, the probable place where allegedly a disputed digital audio recording was made. The methodology considers that digital audio recordings are noisy signals that have two involved noise components. One component is the multiplicative noise, which is an internal feature on the audio recording that is related to the recording device. The other component is the additive noise, which is an external feature on the audio recording that can be related to the recording place...
October 28, 2017: Forensic Science International
https://www.readbyqxmd.com/read/29127334/biological-assessments-of-multifunctional-hydrogel-decorated-implantable-neural-cuff-electrode-for-clinical-neurology-application
#9
Han-Jun Kim, Dong Nyoung Heo, Yi Jae Lee, Sang Jin Lee, Ji Yoon Kang, Soo Hyun Lee, I I Keun Kwon, Sun Hee Do
The implantable cuff electrode is an effective neuroprosthetic device in current nerve tissue engineering. However, biocompatibility and stability are still a serious dispute in terms of in vivo function and continuous monitoring. In this regard, assessing the host's biological response to biomaterials is one of the key factors of chronic implantation. In this article, we analyzed the peripheral nerve specific-biological responses to the application of multi-functional hydrogel-coated electrodes. The surface of the cuff electrode was modified using a multifunctional hydrogel composed of PEG hydrogel, cyclosporin A(CsA)-microsphere(MS) and electrodeposited PEDOT:PSS...
November 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29126443/ubiquitin-c-terminal-hydrolase-isozyme-l1-is-associated-with-shelterin-complex-at-interstitial-telomeric-sites
#10
Aleksandar Ilic, Sumin Lu, Vikram Bhatia, Farhana Begum, Thomas Klonisch, Prasoon Agarwal, Wayne Xu, James R Davie
BACKGROUND: Ubiquitin C-terminal hydrolase isozyme L1 (UCHL1) is primarily expressed in neuronal cells and neuroendocrine cells and has been associated with various diseases, including many cancers. It is a multifunctional protein involved in deubiquitination, ubiquitination and ubiquitin homeostasis, but its specific roles are disputed and still generally undetermined. RESULTS: Herein, we demonstrate that UCHL1 is associated with genomic DNA in certain prostate cancer cell lines, including DU 145 cells derived from a brain metastatic site, and in HEK293T embryonic kidney cells with a neuronal lineage...
November 10, 2017: Epigenetics & Chromatin
https://www.readbyqxmd.com/read/29126146/genomic-and-proteomic-evidence-for-the-presence-of-a-peroxisome-in-the-apicomplexan-parasite-toxoplasma-gondii-and-other-coccidia
#11
Daniel Moog, Jude M Przyborski, Uwe G Maier
Apicomplexans are successful parasites responsible for severe human diseases including malaria, toxoplasmosis and cryptosporidiosis. For many years it has been discussed whether these parasites are in possession of peroxisomes, highly variable eukaryotic organelles usually involved in fatty acid degradation and cellular detoxification. Conflicting experimental data has been published. With the age of genomics, ever more high quality apicomplexan genomes have become available, that now allow a new assessment of the dispute...
November 6, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/29124003/inflammatory-myofibroblastic-tumour-a-case-report-and-a-clinical-update
#12
Neelam N Andrade, Paul C Mathai, Rajpari Kamil, Neha Aggarwal
The Inflammatory myofibroblastic tumor (IMT) is a heterogeneous group of rare lesions consisting predominantly of inflammatory cells and myofibroblastic spindle cells. Head and neck IMTs account for 14 to 18% of extra-pulmonary IMTs [lungs being the most commonly affected regions]. On account of its ambiguous clinical presentation, an IMT needs to be differentiated from other infectious, granulomatous, autoimmune and neoplastic lesions on the basis of histopathologic findings and immunohistochemical analysis...
September 2017: Journal of Oral Biology and Craniofacial Research
https://www.readbyqxmd.com/read/29122054/on-the-substantial-contribution-of-contempt-as-a-folk-affect-concept-to-the-history-of-the-european-popular-institution-of-charivari
#13
Bogdan Neagota, Ileana Benga, Oana Benga
The integration of the folk affect concept of "contempt" into the analysis of the complex institution known generally as charivari is mutually beneficial for both ethno-anthropology (which may thus access inner causes for disputed social and collective behaviors) and evolutionary psychology (which may thus study the length of tradition together with the width of the institution spread, serving the same social functions).
January 2017: Behavioral and Brain Sciences
https://www.readbyqxmd.com/read/29122034/constructing-contempt
#14
Victoria L Spring, C Daryl Cameron, Kurt Gray, Kristen A Lindquist
Gervais & Fessler argue that contempt is a natural kind and that its experience cannot be explained by a constructionist account of emotion. We dispute these claims and offer a positive constructionist model of contempt that accounts for the existing evidence and unifies conflicting findings in the literature on contempt.
January 2017: Behavioral and Brain Sciences
https://www.readbyqxmd.com/read/29122024/prejudice-is-a-general-evaluation-not-a-specific-emotion
#15
Angela J Bahns
Prejudice, like contempt, is a general evaluation rather than a specific emotion. I explore the idea that emotions and attitudes are conceptually distinct by applying Gervais & Fessler's model to the intergroup context. I argue that prejudice is an affective representation of a social group's relational value (friend or foe) and dispute the idea that there are many distinct prejudices.
January 2017: Behavioral and Brain Sciences
https://www.readbyqxmd.com/read/29120652/-hypothyroidism-in-patients-with-heart-disease
#16
Jan Jiskra
Hypothyroidism is frequently found in patients with heart disease. It is a risk factor for atherosclerosis and ischemic heart disease and has a direct negative effect on both the left and right ventricular functions (hypothyroidism-induced cardiomyopathy). The confirmed manifest hypothyroidism is always a reason for replacement therapy with levothyroxine; regarding patients with heart disease, we always begin treatment with a small dose and increase it gradually. The treatment of subclinical hypothyroidism in patients with heart disease is disputable and its benefits probably depend on age...
2017: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29120604/molecular-determinants-for-substrate-interactions-with-the-glycine-transporter-glyt2
#17
Jane E Carland, Michael Thomas, Shannon N Mostyn, Nandhitha Subramanian, Megan Louise O'Mara, Renae M Ryan, Robert J Vandenberg
Transporters in the SLC6 family play key roles in regulating neurotransmission and are the targets for a wide range of therapeutics. Important insights into the transport mechanisms and the specificity of drug interactions of SLC6 transporters have been obtained from the crystal structures of a bacterial homolog of the family, LeuTAa, and more recently the Drosophila dopamine transporter and the human serotonin transporter. However, there is disputed evidence that the bacterial leucine transporter, LeuTAa, contains two substrate binding sites that work cooperatively in the mechanism of transport, with the binding of a second substrate being required for the release of the substrate from the primary site...
November 9, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29120110/observing-facts-and-values-a-brief-theory-and-history
#18
Stephan Fuchs
Not acknowledging the history and metaphysics of the fact/value distinction has led to confusion about the difference between the normative and the cognitive, and disputes on whether there are ways to move from one side, facts, to the other, values. One solution is to recognize values as more "objective" than facts, and thus blur the common way of drawing this distinction. The origin of the distinction between facts and values appears in the space between them, when and where it is uncertain whether an observation becomes fact or value...
November 2017: Canadian Review of Sociology, Revue Canadienne de Sociologie
https://www.readbyqxmd.com/read/29117024/behavioral-genetics-in-criminal-and-civil-courts
#19
Maya Sabatello, Paul S Appelbaum
Although emerging findings in psychiatric and behavioral genetics create hope for improved prevention, diagnosis, and treatment of disorders, the introduction of such data as evidence in criminal and civil proceedings raises a host of ethical, legal, and social issues. Should behavioral and psychiatric genetic data be admissible in judicial proceedings? If so, what are the various means for obtaining such evidence, and for what purposes should its admission be sought and permitted? How could-and should-such evidence affect judicial outcomes in criminal and civil proceedings? And what are the potential implications of using behavioral and psychiatric genetic evidence for individuals and communities, and for societal values of equality and justice? This article provides an overview of the historical and current developments in behavioral genetics...
November 2017: Harvard Review of Psychiatry
https://www.readbyqxmd.com/read/29115932/prognostic-and-clinicopathological-significance-of-circulating-tumor-cells-detected-by-rt-pcr-in-non-metastatic-colorectal-cancer-a-meta-analysis-and-systematic-review
#20
Chaogang Yang, Kun Zou, Liang Zheng, Bin Xiong
BACKGROUND: Circulating tumor cells (CTCs) have been accepted as a prognostic marker in patients with metastatic colorectal cancer (mCRC, UICC stage IV). However, the prognostic value of CTCs in patients with non-metastatic colorectal cancer (non-mCRC, UICC stage I-III) still remains in dispute. A meta-analysis was performed to investigate the prognostic significance of CTCs detected by the RT-PCR method in patients diagnosed with non-mCRC patients. METHODS: A comprehensive literature search for relevant articles was performed in the EmBase, PubMed, Ovid, Web of Science, Cochrane library and Google Scholar databases...
November 7, 2017: BMC Cancer
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