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trans resveratrol

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https://www.readbyqxmd.com/read/28708069/distinct-mechanisms-underlying-resveratrol-mediated-protection-from-types-of-cellular-stress-in-c6-glioma-cells
#1
John C Means, Bryan C Gerdes, Peter Koulen
The polyphenolic phytostilbene, trans-resveratrol, is found in high amounts in several types and tissues of plants, including grapes, and has been proposed to have beneficial effects in the central nervous system due to its activity as an antioxidant. The objective of the present study was to identify the mechanisms underlying the protective effects of resveratrol under conditions of oxidative stress or DNA damage, induced by the extracellularly applied oxidant, tert-butyl hydrogen peroxide, or UV-irradiation, respectively...
July 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28696482/cytotoxicity-and-genotoxicity-of-stilbene-derivatives-in-cho-k1-and-hepg2-cell-lines
#2
Cassia Suemi Mizuno, Winnifred Ampomaah, Fernanda Ribeiro Mendonça, Gabriela Carvalho Andrade, Ariel Maria Nazaré da Silva, Mirian Oliveira Goulart, Raquel Alves Dos Santos
The cytotoxicity and genotoxicity of the stilbenes (E)-methyl-4-(3-5-dimethoxystyryl)benzoate (ester), (E)-4-(3-5-dimethoxystyryl)aniline (amino), (Z)-1,3-dimethoxy-5-(4-methoxystyryl)benzene (cis-TMS) and (E)-1,3-dimethoxy-5-(4-methoxystyryl)benzene (trans-TMS) were investigated in this work. Structural modifications of resveratrol, a naturally occurring stilbene, have been previously performed, including the replacement of hydroxyl by different functional groups. Such modifications resulted in significant improvement of target-specific effects on cell death and antiproliferative responses...
July 10, 2017: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/28656763/glucosylation-of-smoke-derived-volatiles-in-grapevine-vitis-vinifera-is-catalyzed-by-a-promiscuous-resveratrol-guaiacol-glucosyltransferase
#3
Katja Härtl, Fong-Chin Huang, Ashok P Giri, Katrin Franz-Oberdorf, Johanna Frotscher, Yang Shao, Thomas Hoffmann, Wilfried Schwab
Vinification of grapes (Vitis vinifera) exposed to forest fire smoke can yield unpalatable wine due to the presence of taint compounds from smoke and the release of smoke derived volatiles from their respective glycosides during the fermentation process or in-mouth during consumption. To identify glycosyltransferases (GTs) involved in the formation of glycosidically bound smoke-derived volatiles we performed gene expression analysis of candidate GTs in different grapevine tissues. Second, substrates derived from bushfire smoke or naturally occurring in grapes were screened with the candidate recombinant GTs...
July 7, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28655972/high-glucose-level-disturbs-the-resveratrol-evoked-curtailment-of-cx3cl1-cx3cr1-signaling-in-human-placental-circulation
#4
Dariusz Szukiewicz, Michal Pyzlak, Grzegorz Szewczyk, Aleksandra Stangret, Seweryn Trojanowski, Michal Bachanek, Wojciech Braksator, Jaroslaw Wejman
Hyperglycemia-induced hyperactivity of chemokine CX3CL1 (fractalkine) occurs in the human placenta. Anti-inflammatory/antioxidant activities of resveratrol (3,5,4'-trihydroxy-trans-stilbene) are related to the modulation of chemokine CX3CL1 and its receptor, CX3CR1, signaling pathways. We examined the influence of high glucose (25 mmol/L glucose; HG group; N = 36) on resveratrol-mediated effects on CX3CL1 and TNF-α production by the placental lobule, CX3CR1 expression and contents of CX3CR1, TNF-α receptor 1 (TNFR1), and NF-κB proteins in placental tissue...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28646291/application-of-open-access-databases-to-determine-functional-connectivity-between-resveratrol-binding-protein-qr2-and-colorectal-carcinoma
#5
Barbara B Doonan, Evelien Schaafsma, John T Pinto, Joseph M Wu, Tze-Chen Hsieh
Colorectal cancer (CRC) is a major cause of cancer-associated deaths worldwide. Recently, oral administration of resveratrol (trans-3,5,4'-trihydroxystilbene) has been reported to significantly reduce tumor proliferation in colorectal cancer patients, however, with little specific information on functional connections. The pathogenesis and development of colorectal cancer is a multistep process that can be categorized using three phenotypic pathways, respectively, chromosome instability (CIN), microsatellite instability (MSI), and CpG island methylator (CIMP)...
August 2017: In Vitro Cellular & Developmental Biology. Animal
https://www.readbyqxmd.com/read/28608248/the-analgesic-effect-of-trans-resveratrol-is-regulated-by-calcium-channels-in-the-hippocampus-of-mice
#6
Weijie Wang, Yingcong Yu, Jing Li, Lin Wang, Zhi Li, Chong Zhang, Linlin Zhen, Lianshu Ding, Gang Wang, Xiaoyang Sun, Ying Xu
Resveratrol has been widely studied in terms of it's potential to slow the progression of many diseases. But little is known about the mechanism of action in neuropathic pain. Neuropathic pain is the main type of chronic pain associated with tissue injury. Calcium channels and calcium/caffeine-sensitive pools are associated with analgesic pathway involving neuropathic pain. Our previous study suggested that the antinociceptive effect of resveratrol was involved in Ca(2+)/calmodulin-dependent signaling in the spinal cord of mice...
August 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28604618/trans-resveratrol-supplementation-and-endothelial-function-during-the-fasting-and-postprandial-phase-a-randomized-placebo-controlled-trial-in-overweight-and-slightly-obese-participants
#7
Sanne M van der Made, Jogchum Plat, Ronald P Mensink
Studies on the effects of the long-term intake of trans-resveratrol on vascular function are conflicting. In addition, postprandial effects of long-term trans-resveratrol intake on endothelial function are not known. We therefore supplemented 45 overweight and slightly obese volunteers (25 men and 20 women) with a mean (±SD) age of 61 ± 7 years and body mass index of 28.3 ± 3.2 kg/m² in random order trans-resveratrol (2 × 75 mg/day) or placebo capsules for 4 weeks, separated by a washout period of at least 4 weeks...
June 12, 2017: Nutrients
https://www.readbyqxmd.com/read/28599439/anti-proliferative-and-anti-metastasis-effects-of-ten-oligostilbenes-from-the-seeds-of-paeonia-suffruticosa-on-human-cancer-cells
#8
Ying Gao, Chunnian He
Paeonia suffruticosa from the section Moutan of the genus Paeonia is an important Chinese medicinal herb. In our previous study, 10 oligostilbenes from the seeds of P. suffruticosa, including trans-resveratrol and its dimers and trimers, were isolated and identified. In the present study, the anti-proliferative effects of these 10 oligostilbenes were systemically evaluated in a panel of human lung, breast and bone cancer cell lines, and their apoptotic effects were analyzed using a high-content multiplex apoptosis assay and a fluorescent caspase-3/7 assay...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28595952/trans-resveratrol-enriched-maternal-diet-protects-the-immature-hippocampus-from-perinatal-asphyxia-in-rats
#9
Sebastian Isac, Anca Maria Panaitescu, Ana Spataru, Mara Iesanu, Alexandra Totan, Amalia Udriste, Natalia Cucu, Gheorghe Peltecu, Leon Zagrean, Ana-Maria Zagrean
Trans-resveratrol (tRESV), a polyphenol with antioxidant properties, is common in many food sources, hence easily accessible for study as a maternal dietary supplement in perinatal asphyxia (PA). Hypoxic-ischemic encephalopathy secondary to PA affects especially vulnerable brain areas such as hippocampus and is a leading cause of neonatal morbidity. The purpose of this study is to identify new epigenetic mechanisms of brain inflammation and injury related to PA and to explore the benefit of tRESV enriched maternal diet...
July 13, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28595835/the-effect-of-resveratrol-its-naturally-occurring-derivatives-and-tannic-acid-on-the-induction-of-cell-cycle-arrest-and-apoptosis-in-rat-c6-and-human-t98g-glioma-cell-lines
#10
Małgorzata Zielińska-Przyjemska, Mariusz Kaczmarek, Violetta Krajka-Kuźniak, Michał Łuczak, Wanda Baer-Dubowska
Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a potent chemopreventive and potentially cancer therapeutic agent. Since rapid metabolism limits resveratrol bioavailability, derivatives less prone to metabolic transformation are being sought and tested. We evaluated the effect of resveratrol, and its analogs (pterostilbene and 3,5,4'-trimethoxystilbene) along with tannic acid, on cell cycle and apoptosis in rat C6 and human T98G glioma cells. At concentration ranges both lower and higher than IC50 calculated based on MTT assay, all these polyphenols affected the cell cycle distribution...
June 6, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28587209/variability-in-the-content-of-trans-resveratrol-trans-%C3%AE%C2%B5-viniferin-and-r2-viniferin-in-grape-cane-of-seven-vitis-vinifera-l-varieties-during-a-three-year-study
#11
Jan Tříska, Naděžda Vrchotová, Josef Balík, Ivo Soural, Radek Sotolář
Grape canes are a waste product from viticulture that show potential as an industrially extractable source of stilbenes, which are valuable for medical and other purposes. In this work, grape canes collected in three consecutive years (2014-2016) at six different places in South Moravia, Czech Republic were extracted, and the contents of trans-resveratrol, trans-ε-viniferin, and r2-viniferin were determined by high-performance liquid chromatography. The study included three blue grape varieties of Vitis vinifera L...
June 3, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28575856/trans-4-4-dihydroxystilbene-dhs-inhibits-human-neuroblastoma-tumor-growth-and-induces-mitochondrial-and-lysosomal-damages-in-neuroblastoma-cell-lines
#12
Bhaskar Saha, Birija Sankar Patro, Mrunesh Koli, Ganesh Pai, Jharna Ray, Sandip K Bandyopadhyay, Subrata Chattopadhyay
In view of the inadequacy of neuroblastoma treatment, five hydroxystilbenes and resveratrol (Resv) were screened for their cytotoxic property against human neuroblastoma cell lines. The mechanism of cytotoxic action of the most potent compound, trans-4,4'-dihydroxystilbene (DHS) was investigated in vitro using human neuroblastoma cell lines. DHS was also tested in a mouse xenograft model of human neuroblastoma tumor. The MTT, sub-G1, annexin V and clonogenic assays as well as microscopy established higher cytotoxicity of DHS than Resv to the IMR32 cell line...
May 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28570943/%C3%AE-glucosidase-inhibitory-effect-of-resveratrol-and-piceatannol
#13
Albert J Zhang, Agnes M Rimando, Cassia S Mizuno, Suresh T Mathews
Dietary polyphenols have been shown to inhibit α-glucosidase, an enzyme target of some antidiabetic drugs. Resveratrol, a polyphenol found in grapes and wine, has been reported to inhibit the activity of yeast α-glucosidase. This triggered our interest to synthesize analogs and determine their effect on mammalian α-glucosidase activity. Using either sucrose or maltose as substrate resveratrol, piceatannol and 3'-hydroxypterostilbene showed strong inhibition of mammalian α-glucosidase activity; pinostilbene, cis-desoxyrhapontigenin and trans-desoxyrhapontigenin had moderate inhibition...
May 25, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28566983/the-radioprotective-effect-of-resveratrol-against-genotoxicity-induced-by-%C3%AE-irradiation-in-mice-blood-lymphocytes
#14
Farideh Koohian, Ahmad Shanei, Daryoush Shahbazi-Gahrouei, Seyed Hossein Hejazi, Mohammad-Taghi Moradi
In this study, we evaluated whether the protective potential of resveratrol (RSV; 3,5,4'-trihydroxy-trans-stilbene) against γ-radiation caused damages in peripheral blood lymphocyte of mice. Resveratrol as a polyphenolic compound scavenges free radicals. Various doses of RSV were administered intraperitoneally 2 hours to adult male mice before a single dose of whole-body γ-irradiation (2 Gy). To assess the protective ability of RSV, the alkaline comet assay in blood lymphocyte of mice was performed and the total comet score was evaluated...
April 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28565810/anti-atherogenic-properties-of-resveratrol-4-week-resveratrol-administration-associated-with-serum-concentrations-of-sirt1-adiponectin-s100a8-a9-and-vsmcs-contractility-in-a-rat-model
#15
Michał Wiciński, Bartosz Malinowski, Mateusz M Węclewicz, Elżbieta Grześk, Grzegorz Grześk
Resveratrol (3, 4', 5-trihydroxy-trans-stilbene) is a natural, non-flavonoid polyphenol that exerts protective properties against atherosclerosis-associated endothelial dysfunction and senescence. The present study aimed to assess the influence of resveratrol on vascular contractility and molecular factors including sirtuin-1 (SIRT1), adiponectin and calprotectin (S100A8/A9) that are considered to be important elements of atherogenesis. A total of 17 male rats were divided into a control and treatment group and administered resveratrol or a placebo...
May 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28513542/biomimetic-synthesis-of-resveratrol-trimers-catalyzed-by-horseradish-peroxidase
#16
Jian-Qiao Zhang, Gan-Peng Li, Yu-Long Kang, Bin-Hao Teng, Chun-Suo Yao
Biotransformation of trans-resveratrol and synthetic (±)-ε-viniferin in aqueous acetone using horseradish peroxidase and hydrogen peroxide as oxidants resulted in the isolation of two new resveratrol trimers (3 and 4), one new resveratrol derivative (5) with a dihydrobenzofuran skeleton, together with two known stilbene trimers (6 and 7), and six known stilbene dimers (8-13). Their structures and relative configurations were identified through spectral analysis and possible formation mechanisms were also discussed...
May 17, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28507012/dietary-factors-promoting-brown-and-beige-fat-development-and-thermogenesis
#17
REVIEW
Meshail Okla, Jiyoung Kim, Karsten Koehler, Soonkyu Chung
Brown adipose tissue (BAT) is a specialized fat tissue that has a high capacity to dissociate cellular respiration from ATP utilization, resulting in the release of stored energy as heat. Adult humans possess a substantial amount of BAT in the form of constitutively active brown fat or inducible beige fat. BAT activity in humans is inversely correlated with adiposity, blood glucose concentrations, and insulin sensitivity; this suggests that strategies aimed at BAT-mediated bioenergetics are an attractive therapeutic target in combating the continuing epidemic of obesity and diabetes...
May 2017: Advances in Nutrition
https://www.readbyqxmd.com/read/28489607/trans-scirpusin-a-showed-antitumor-effects-via-autophagy-activation-and-apoptosis-induction-of-colorectal-cancer-cells
#18
Eun-Hye Hong, Eun-Young Heo, Jae-Hyoung Song, Bo-Eun Kwon, Jae-Young Lee, Yaejeong Park, Jinwoong Kim, Sun-Young Chang, Young-Won Chin, Sang-Min Jeon, Hyun-Jeong Ko
Trans-Scirpusin A (TSA) is a resveratrol oligomer found in Borassus flabellifer L. We found that TSA inhibited the growth of colorectal cancer Her2/CT26 cells in vivo in mice. Although some cytotoxic T lymphocytes (CTLs) were induced against the tumor-associated antigen Her2, TSA treatment did not significantly increase the level of Her2-specific CTL response compared to that with vehicle treatment. However, there was a significant increase in the level of TNF-α mRNA in tumor tissue and Her2-specific Ab (antibody) production...
June 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/28484711/rapid-identification-and-isolation-of-inhibitors-of-rat-lens-aldose-reductase-and-antioxidant-in-maackia-amurensis
#19
Set Byeol Kim, Seung Hwan Hwang, Zhiqiang Wang, Jae Myung Yu, Soon Sung Lim
Oxidative stress and aldose reductase activity have been implicated in the development of diabetic complications. In this study, the antioxidant and aldose reductase (AR) inhibitory effects of Maackia amurensis (MA) were investigated. The ethyl acetate fraction of the MA extract showed the highest inhibitory activity in antioxidant and rat lens AR (RLAR). To identify and isolate the active components in the ethyl acetate fraction of the MA extract, high-speed countercurrent chromatography and Sephadex LH-20 column chromatography were performed and guided by an offline HPLC-ABTS assay and HPLC microfractionation AR assay...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28475242/a-simple-lc-ms-ms-method-facilitated-by-salting-out-assisted-liquid-liquid-extraction-salle-to-simultaneously-determine-trans-resveratrol-res-its-glucuronide-and-sulfate-conjugates-in-rat-plasma-and-its-application-to-pharmacokinetic-assay
#20
Zhixia Qiu, Jiaojiao Yu, Yu Dai, Yue Yang, Xiaoyu Lu, Jiaqiu Xu, Zhiying Qin, Fang Huang, Ning Li
A simple LC-MS/MS method facilitated by salting-out assisted liquid-liquid extraction (SALLE) was applied to simultaneously investigate pharmacokinetics of trans-resveratrol (Res), its major glucuronide and sulfate conjugates in rat plasma. Acetonitrile-methanol (80:20, v/v) and ammonium acetate (10 mol∙L(-1) ) were used as extractant and salting-out reagent to locate the target analytes in the supernatant after the aqueous and organic phase stratification, then the analytes were determined via gradient elution by LC-MS/MS in negative mode in a single run...
May 5, 2017: Biomedical Chromatography: BMC
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