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trans resveratrol

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https://www.readbyqxmd.com/read/28437699/structure-and-dynamics-of-cetyltrimethylammonium-chloride-sodium-dodecylsulfate-ctac-sds-catanionic-vesicles-high-value-nano-vehicles-from-low-cost-surfactants
#1
Irene Russo Krauss, Riccardo Imperatore, Augusta De Santis, Alessandra Luchini, Luigi Paduano, Gerardino D'Errico
HYPOTHESIS: Catanionic vesicles based on large-scale produced surfactants represent a promising platform for the design of innovative, effective and relatively inexpensive nano-vehicles for a variety of actives. Structural, dynamic and functional behavior of these aggregates is finely tuned by the molecular features of their components and can be opportunely tailored for their applications as drug carriers. EXPERIMENTS: Here we investigate the aggregates formed by CTAC and SDS, two of the most diffused surfactants, by means of Dynamic Light Scattering, Small Angle Neutron Scattering and Electron Paramagnetic Resonance spectroscopy (EPR)...
April 12, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28429008/anticancer-effects-of-novel-resveratrol-analogues-on-human-ovarian-cancer-cells
#2
Daniele Vergara, Stefania De Domenico, Andrea Tinelli, Eleonora Stanca, Loretta L Del Mercato, Anna M Giudetti, Pasquale Simeone, Nicola Guazzelli, Marco Lessi, Chiara Manzini, Angelo Santino, Fabio Bellina, Michele Maffia
Resveratrol, a naturally occurring phytoalexin, has long been known to play an important regulatory role in key functions in cell physiology. This multifunctional role of resveratrol is explained by its ability to interact with several targets of various cell pathways. In the recent past, synthetic chemical modifications have been made in an attempt to enhance the biological effects of resveratrol, including its anti-cancer properties. In this study, we investigated the molecular mechanisms of action of novel trans-restricted analogues of resveratrol in which the C-C double bond of the natural derivative has been replaced by diaryl-substituted imidazole analogues...
April 21, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/28419719/spectroscopic-evidences-of-toxic-trans-crotonaldehyde-trapped-and-transformed-by-resveratrol-to-prevent-the-damage-of-mitochondrial-dna
#3
Yanwen Su, Lei Chen, Yanbin Su, Zhengqiang Li, Chuang Zhang, Tongxing Mu
The purpose of this study is to probe the spectroscopic evidences of toxic trans-crotonaldehyde (TCA) trapped and transformed by resveratrol (Res) to prevent the damage of mitochondrial DNA. In aldehyde dehydrogenase (ALDH) at the different pH or mitochondria, the spectroscopic characteristics of TCA trapped and transformed by Res were observed by means of both UV-vis and Raman spectra. When Res interacted with TCA, TCA peak at 316 nm immediately disappeared while Res main peak at 305 nm and shoulder peak at 320 nm were dramatically changed, Raman peaks of TCA at 1,688 cm(-1) assigned to CHO and 1,641 cm(-1) affiliated to CC were strikingly shifted, Raman peaks of Res itself were significantly displaced or disappeared, especially in mitochondria and ALDH at different pH...
April 16, 2017: IUBMB Life
https://www.readbyqxmd.com/read/28409021/tissue-distribution-of-trans-resveratrol-and-its-metabolites-after-oral-administration-in-human-eyes
#4
Shuaishuai Wang, Zheng Wang, Shuo Yang, Tiemei Yin, Yaoli Zhang, Yuanjun Qin, Robert N Weinreb, Xufang Sun
Purpose. This study was performed to measure the concentration of trans-resveratrol and its three metabolites in human eyes. Methods. The patients who underwent pars plana vitrectomy for rhegmatogenous retinal detachment were included. The participants were orally given trans-resveratrol-based supplement (Longevinex®). A suitable amount of conjunctiva, aqueous humor, and vitreous humor were obtained during the operation. High-performance liquid chromatography (HPLC) with mass spectrometry (LC/MS/MS) was used to detect the concentration of trans-resveratrol and its three metabolites in the various samples...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28403783/synthesis-and-evaluation-of-2-naphthaleno-trans-stilbenes-and-cyanostilbenes-as-anticancer-agents
#5
Nikhil R Madadi, Narsimha R Penthala, Amit Ketkar, Robert L Eoff, Vicenta Trujullo-Alonso, Monica L Guzman, Peter A Crooks
A series of novel 2-naphthaleno stilbenes (3a-3h) and cyanostilbenes (5a-5h) have been synthesized as analogs of resveratrol and DMU-212, and evaluated for their anticancer activity against a panel of 54 human cancer cell lines. The analog 5c ((Z)-3-(naphthalen-2-yl)-2-(3,4,5-trimethoxyphenyl) acrylonitrile) was significantly effective against four particular cancer cell lines: i.e. colon cancer cell line COLO 205, CNS cancer cell line SF 539 and melanoma cancer cell lines SK-MEL 5 and MDA-MB-435 with GI50 values of 22 nM, 25 nM, 23 nM and 21 nM, respectively...
April 12, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28402662/dominant-carbons-in-trans-and-cis-resveratrol-isomerization
#6
Feng Wang, Subhojyoti Chatterjee
A comprehensive analysis for isomerization of geometric isomers in case of resveratrol is been presented. As an important red wine molecule, only one geometric isomer of resveratrol, i.e., trans-R rather than cis-R is primarily associated with health benefit. In the present study, density function theory (DFT) provides accurate descriptions of isomerization of resveratrol. The nearly planar trans-R forms a relatively rigid and less flexible conjugate network but the non-planar cis-R favors a more flexible structure with steric through space interaction...
April 12, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28350759/resveratrol-supplementation-reduces-pain-experience-by-postmenopausal-women
#7
Rachel H X Wong, Hamish M Evans, Peter R C Howe
OBJECTIVE: Pain is a common complaint among postmenopausal women. It has been postulated that vascular dysfunction caused by estrogen decline at menopause plays a key role in the initiation and progression of degradative joint disease, namely age-related osteoarthritis. We evaluated whether supplementation with resveratrol, a phytoestrogen, could improve aspects of well-being such as chronic pain that is commonly experienced by postmenopausal women. METHODS: A 14-week randomized, double-blind, placebo-controlled intervention with trans-resveratrol (75 mg, twice daily) was conducted in 80 healthy postmenopausal women...
March 27, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28338616/a-comparative-study-of-phenols-in-apulian-italian-wines
#8
Andrea Ragusa, Carla Centonze, Maria E Grasso, Maria F Latronico, Pier F Mastrangelo, Federica Sparascio, Francesco P Fanizzi, Michele Maffia
Nutraceutics is a growing research field in which researchers study and attempt to improve the biological properties of metabolites in food. Wine is one of the most consumed products in the world and contains a plethora of molecules biologically relevant to human health. In this article, several polyphenols with potential antioxidant activity were measured in wines from Apulia, in Southeast Italy. Hydroxytyrosol, gallic and syringic acids, luteolin, quercetin, and trans-resveratrol were identified and quantified by HPLC...
March 24, 2017: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28324165/lipid-phenol-and-carotenoid-changes-in-bianca-grapevine-leaves-after-mechanical-wounding-a-case-study
#9
Giulia Chitarrini, Luca Zulini, Domenico Masuero, Urska Vrhovsek
Metabolic changes can occur in plants in response to abiotic stress. Extensive use of leaf discs (mechanical wounding) in studies regarding the effect on the biochemical response of the grapevine to different types of biotic stress makes it necessary to understand metabolic perturbation after injury. In this study, we investigate how mechanical wounding can affect the metabolism of grapevine leaf tissue using Bianca variety as case study. Two sizes of leaf discs (1.1 and 2.8 cm in diameter) were excised from leaves, and phenol, lipid and carotenoid perturbation were investigated 0, 6, 12, 24, 48, 96 and 120 h post cutting...
March 21, 2017: Protoplasma
https://www.readbyqxmd.com/read/28319852/pterostilbene-a-dimethylated-analog-of-resveratrol-promotes-energy-metabolism-in-obese-rats
#10
Koji Nagao, Tomoyuki Jinnouchi, Shunichi Kai, Teruyoshi Yanagita
Pterostilbene (trans-3,5-dimethoxy-4-hydroxystilbene) is a dimethylated analog of resveratrol and has been reported to exert various pharmacological effects. In this study, we evaluated the effect of pterostilbene on the pathogenesis of obesity and energy metabolism in obese rats. Pterostilbene significantly activates silent mating type information regulation 2 homolog-1 and peroxisome proliferator-activated receptor-alpha in vitro. At 4 weeks a 0.5% pterostilbene diet markedly suppressed the abdominal white adipose tissue (WAT) accumulation in obese rats...
March 8, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28300445/botanicals-with-dermatologic-properties-derived-from-first-nations-healing
#11
Sophia Colantonio, Jason K Rivers
INTRODUCTION: First Nations people have a long history of working with medicinal plants used to treat skin diseases. The purpose was to assess the dermatologic therapeutic potential of western red cedar, white spruce, birch, balsam poplar, and black spruce. METHODS: Based on expert recommendations, 5 trees were selected that were used in First Nations medicine for cutaneous healing and have potential and/or current application to dermatology today. We searched several databases up to June 12, 2014...
February 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28298699/searching-trans-resveratrol-in-fruits-and-vegetables-a-preliminary-screening
#12
Natividad Sebastià, Alegría Montoro, Zacarías León, Jose M Soriano
Resveratrol is a phytoalexin with potent anti-inflammatory, anti-oxidant and anti-carcinogenic effects. The object of this work was to determine whether this promising compound was present in the typical fruits and vegetables used in the Mediterranean diet. Our results indicated the presence of trans-resveratrol in concentrations ranging from 0.2 µg/g in tomatoes and 3 lg/g. in strawberries.
March 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28279696/hydroxystilbenes-and-methoxystilbenes-activate-human-aryl-hydrocarbon-receptor-and-induce-cyp1a-genes-in-human-hepatoma-cells-and-human-hepatocytes
#13
Barbora Pastorková, Aneta Vrzalová, Petr Bachleda, Zdeněk Dvořák
Natural polyphenol resveratrol (trihydroxystilbene) is a partial agonist of human aryl hydrocarbon receptor AhR, thereby, displaying a plethora of biological effects. Biological activities of metoxylated and hydroxylated stilbenes were studied in the past. The aim of the current study was to describe the effects of 13 different hydroxy- and methoxystilbenes, including their cis/trans isomers on the transcriptional activity of AhR and the expression of CYP1A genes in hepatic cancer cells HepG2 and in primary human hepatocytes...
March 6, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28278187/resveratrol-ameliorates-the-chemical-and-microbial-induction-of-inflammation-and-insulin-resistance-in-human-placenta-adipose-tissue-and-skeletal-muscle
#14
Ha T Tran, Stella Liong, Ratana Lim, Gillian Barker, Martha Lappas
Gestational diabetes mellitus (GDM), which complicates up to 20% of all pregnancies, is associated with low-grade maternal inflammation and peripheral insulin resistance. Sterile inflammation and infection are key mediators of this inflammation and peripheral insulin resistance. Resveratrol, a stilbene-type phytophenol, has been implicated to exert beneficial properties including potent anti-inflammatory and antidiabetic effects in non-pregnant humans and experimental animal models of GDM. However, studies showing the effects of resveratrol on inflammation and insulin resistance associated with GDM in human tissues have been limited...
2017: PloS One
https://www.readbyqxmd.com/read/28272361/a-focused-multiple-reaction-monitoring-mrm-quantitative-method-for-bioactive-grapevine-stilbenes-by-ultra-high-performance-liquid-chromatography-coupled-to-triple-quadrupole-mass-spectrometry-uhplc-qqq
#15
Elías Hurtado-Gaitán, Susana Sellés-Marchart, Ascensión Martínez-Márquez, Antonio Samper-Herrero, Roque Bru-Martínez
Grapevine stilbenes are a family of polyphenols which derive from trans-resveratrol having antifungal and antimicrobial properties, thus being considered as phytoalexins. In addition to their diverse bioactive properties in animal models, they highlight a strong potential in human health maintenance and promotion. Due to this relevance, highly-specific qualitative and quantitative methods of analysis are necessary to accurately analyze stilbenes in different matrices derived from grapevine. Here, we developed a rapid, sensitive, and specific analysis method using ultra-high-performance liquid chromatography coupled to triple-quadrupole mass spectrometry (UHPLC-QqQ) in MRM mode to detect and quantify five grapevine stilbenes, trans-resveratrol, trans-piceid, trans-piceatannol, trans-pterostilbene, and trans-ε-viniferin, whose interest in relation to human health is continuously growing...
March 7, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28230758/quantitative-determination-of-stilbenoids-and-dihydroisocoumarins-in-shorea-roxburghii-and-evaluation-of-their-hepatoprotective-activity
#16
Kiyofumi Ninomiya, Saowanee Chaipech, Yusuke Kunikata, Ryohei Yagi, Yutana Pongpiriyadacha, Osamu Muraoka, Toshio Morikawa
A simultaneous quantitative analytical method for 13 stilbenoids including (-)-hopeaphenol (1), (+)-isohopeaphenol (2), hemsleyanol D (3), (-)-ampelopsin H (4), vaticanols A (5), E (6), and G (7), (+)-α-viniferin (8), pauciflorol A (9), hopeafuran (10), (-)-balanocarpol (11), (-)-ampelopsin A (12), and trans-resveratrol 10-C-β-d-glucopyranoside (13), and two dihydroisocoumarins, phayomphenols A₁ (14) and A₂ (15) in the extract of Shorea roxburghii (dipterocarpaceae) was developed. According to the established protocol, distributions of these 15 polyphenols (1-15) in the bark and wood parts of S...
February 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28226267/a-simple-lc-ms-ms-method-for-the-simultaneous-quantification-of-resveratrol-and-its-major-phase-ii-metabolites-assessment-of-their-urinary-and-biliary-excretions-in-rats
#17
Zhixia Qiu, Jiaojiao Yu, Yu Dai, Xijing Chen, Fang Huang, Ning Li
Trans-resveratrol (Res) is rapidly metabolized, extensively distributed into various tissues and mainly excreted by urine. The present study aimed to establish a simple LC-MS/MS method to simultaneously quantify Res and its major phase II metabolites (Res-3-O-β-d-glucuronide, R3G; Res-4'-O-β-d-glucuronide, R4'G; Res-resveratrol 3-sulfate, R3S; and Res-4'-sulfate, R4'S), and apply this method to assess their urinary and biliary excretions in rats. A simplified salting-out assisted liquid-liquid extraction (SALLE) strategy was developed to prepare samples with acetonitrile-methanol mixture (8:2, v/v) as extractant and ammonium acetate solution (10M) as salting-out reagent...
March 24, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28214727/a-new-strategy-to-enhance-the-biosynthesis-of-trans-resveratrol-by-overexpressing-stilbene-synthase-gene-in-elicited-vitis-vinifera-cell-cultures
#18
Mingyu Chu, M A Pedreño, Nuria Alburquerque, Lydia Faize, Lorenzo Burgos, Lorena Almagro
In this work, transgenic lines of suspension cultured cells of Vitis vinifera cv. Monastrell containing the plasmid pMOG800-sts have been obtained. The cell growth of these transgenic cell lines decreased slightly as compared to non-transgenic suspension cultured cells, while cell viability was not affected. In addition, the elicitation with cyclodextrins and methyl jasmonate enhanced the production of trans-resveratrol, observing the highest levels of this compound in sts-expressing transgenic Vitis suspension cultured cells with the sts expression cassette in the forwards orientation...
April 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28194730/preparation-and-in-vitro-in-vivo-characterization-of-trans-resveratrol-nanocrystals-for-oral-administration
#19
Sandeep K Singh, Vishal Makadia, Shweta Sharma, Mamunur Rashid, Sudhir Shahi, Prabhat R Mishra, Mohammed Wahajuddin, Jiaur R Gayen
Trans -resveratrol (t-RES) is a natural polyphenolic compound with extensive therapeutic activities; however, its clinical application is circumscribed due to its poor solubility and low bioavailability. The purpose of this study was to prepare stable t-RES nanocrystals (t-RES-NCs) with different stabilizers to improve its oral bioavailability. t-RES-NCs were fabricated by the probe sonication method and optimized by particles size, poly dispersive index and zeta potential. The pharmaceutical characterization of t-RES-NCs was further performed systematically...
February 13, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28168876/characterization-of-stilbene-synthase-genes-in-mulberry-morus-atropurpurea-and-metabolic-engineering-for-the-production-of-resveratrol-in-escherichia-coli
#20
Chuanhong Wang, Shuang Zhi, Changying Liu, Fengxiang Xu, Ai Chun Zhao, Xiling Wang, Yanhong Ren, Zhengang Li, Maode Yu
Stilbenes have been recognized for their beneficial physiological effects on human health. Stilbene synthase (STS) is the key enzyme of resveratrol biosynthesis and has been studied in numerous plants. Here, four MaSTS genes were isolated and identified in mulberry (Morus atropurpurea Roxb.). The expression levels of MaSTS genes and the accumulation of trans-resveratrol, trans-oxyresveratrol and trans-mulberroside A were investigated in different plant organs. A novel co-expression system that harbored 4-coumarate:CoA ligase gene (Ma4CL) and MaSTS was established...
February 7, 2017: Journal of Agricultural and Food Chemistry
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