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trans resveratrol

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https://www.readbyqxmd.com/read/27904389/performance-of-different-natural-antioxidant-compounds%C3%A2-in-frying-oil
#1
Buket Aydenız, Emin Yilmaz
In this study, the natural green tea extract, purified lycopene, purified resveratrol and purified γ-oryzanol were added into peanut oil and their antioxidant performances were evaluated during frying. Moreover, the sensory properties of fried dough were evaluated to determine the consumption feasibility. All natural antioxidants led to significant increase in the stability of the oil samples. The ranges of measurements in the treatment groups were as follows: free acidity 0.1-2.9 g of oleic acid per 100 g of oil, conjugated dienes 0...
March 2016: Food Technology and Biotechnology
https://www.readbyqxmd.com/read/27895698/combinations-of-bio-active-dietary-constituents-affect-human-white-adipocyte-function-in-vitro
#2
Ines Warnke, Johan W E Jocken, Rotraut Schoop, Christine Toepfer, Regina Goralczyk, Joseph Schwager
BACKGROUND: Specific bio-active dietary compounds modulate numerous metabolic processes in adipose tissue (AT), including pre-adipocyte proliferation and differentiation. AT dysfunction, rather than an increased fat mass per se, is strongly associated with the development of insulin resistance and is characterized by impaired adipogenesis, hypertrophic adipocytes, inflammation, and impairments in substrate metabolism. A better understanding of mechanisms underlying AT dysfunction may provide new strategies for the treatment of obesity-associated metabolic diseases...
2016: Nutrition & Metabolism
https://www.readbyqxmd.com/read/27882602/the-resveratrol-derivatives-trans-3-5-dimethoxy-4-fluoro-4-hydroxystilbene-and-trans-2-4-5-trihydroxystilbene-decrease-oxidative-stress-and-prolong-lifespan-in-caenorhabditis-elegans
#3
Nadine Fischer, Christian Büchter, Karoline Koch, Sabrina Albert, René Csuk, Wim Wätjen
OBJECTIVES: Resveratrol (trans-3,4',5-trihydroxystilbene (1)) was previously shown to extend the lifespan of different model organisms. However, its pharmacological efficiency is controversially discussed. Therefore, the bioactivity of four newly synthesized stilbenes (trans-3,5-dimethoxy-4-fluoro-4'-hydroxystilbene (3), trans-4'-hydroxy-3,4,5-trifluorostilbene (4), trans-2,5-dimethoxy-4'-hydroxystilbene (5), trans-2,4',5-trihydroxystilbene (6)) was compared to (1) and pterostilbene (trans-3,5-dimethoxy-4'-hydroxystilbene (2)) in the established model organism Caenorhabditis elegans...
November 23, 2016: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/27854074/resveratrol-and-its-methoxy-derivatives-modulate-the-expression-of-estrogen-metabolism-enzymes-in-breast-epithelial-cells-by-ahr-down-regulation
#4
Barbara Licznerska, Hanna Szaefer, Marcin Wierzchowski, Hanna Sobierajska, Wanda Baer-Dubowska
Our earlier studies have shown that compared to resveratrol, its analogs with ortho-methoxy substituents exert stronger antiproliferative and proapoptotic activity. Since estrogens are considered the major risk factors of breast carcinogenesis, the aim of this study was to evaluate the effect of 3,4,2'-trimethoxy (3MS), 3,4,2',4'-tetramethoxy (4MS), and 3,4,2',4',6'-pentamethoxy (5MS) trans-stilbenes on the constitutive expression of the enzymes involved in estrogen metabolism, as well as receptors: AhR and HER2 in breast epithelial cell line MCF10A...
November 16, 2016: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/27834152/research-problems-associated-with-resveratrol-trans-3-5-4-trihydroxystilbene-rsv-and-various-strategies-to-overcome-those-problems-review
#5
Monika, Garg R, Sardana S K
BACKGROUND: Resveratrol belonging to stilbene family has emerged as a leading candidate for enhancing the health span by potentially decreasing the aging process and reducing chronic diseases. OBJECTIVE: The aim of this review is to focus on various studies related to chemical composition l, pharmacological activities, bioavailability problems associated with resveratrol. In addition, it includes section discussing the challenges associated with drug and strategies to improve resveratrol solubility, stability and bioavailability...
November 9, 2016: Current Drug Delivery
https://www.readbyqxmd.com/read/27818239/determination-of-trans-resveratrol-and-its-metabolites-in-rat-serum-using-liquid-chromatography-with-high-resolution-time-of-flight-mass-spectrometry
#6
Jana Rousova, Kari Kusler, Duminda Liyanage, Mary Leadbetter, Nagaraju Dongari, Ke K Zhang, Alexei Novikov, Edward R Sauter, Alena Kubátová
In this study we developed a sensitive method using high performance liquid chromatography (HPLC) coupled to electrospray ionization (ESI) with high resolution time of flight (TOF) mass spectrometry (MS) for the determination of naturally occurring antioxidant trans-resveratrol (3,5,4'-trihydroxy-trans-stilbene, RES). This method enabled an investigation of a relationship between tumor growth in rats and concentration of RES and its primary metabolites, trans-resveratrol-3-O-sulfate-3-O-sulfate (R3S) and trans-resveratrol-3-O-β-d-glucuronide (R3G), in rat serum after RES exposure (5 or 25mg/kg/day)...
October 29, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27776460/the-influence-of-antioxidants-in-the-thiyl-radical-induced-lipid-peroxidation-and-geometrical-isomerization-in-micelles-of-linoleic-acid
#7
Ivana Tartaro Bujak, Branka Mihaljević, Carla Ferreri, Chryssostomos Chatgilialoglu
The biomimetic model of micelles of linoleic acid containing 2-mercaptoethanol and the antioxidant was examined under gamma irradiation up to 400 Gy in aerobic or deoxygenated conditions where thiyl radicals are the main reactive species. Lipid peroxidation was retarded by ascorbic acid and α-tocopherol, whereas this process was strongly inhibited by resveratrol as effectively as the ascorbic acid/α-tocopherol mixture. Furthermore, antioxidants have a much stronger inhibitory effect on the peroxidation in the presence of 2-mercaptoethanol, and at the same time show protective properties of the double bond, decreasing the cis-trans isomerization...
October 25, 2016: Free Radical Research
https://www.readbyqxmd.com/read/27754235/os-34-02-concentration-dependent-effect-of-plasma-resveratrol-on-cerebral-vasodilator-responsiveness-cvr-in-adults-with-type-2-diabetes-mellitus-t2dm
#8
Rachel Wong, Rhenan Nealon, Daniel Raederstorff, Peter Howe
OBJECTIVE: Having shown that resveratrol consumption can improve flow mediated dilation of the brachial artery, we tested its effects on CVR to hypercapnia in adults with T2DM, a risk population for cerebrovascular disease and cognitive impairments. DESIGN AND METHOD: In a double-blind crossover trial, 34 adults with T2DM consumed 0, 75, 150 and 300 mg of synthetic trans-resveratrol (one dose per week in random order). Before and 1-2 hr after dosing, transcranial Doppler ultrasound was used to assess CVR to a hypercapnic stimulus (breathing Carbogen gas for 3 min) in the middle (MCA) and posterior (PCA) cerebral arteries...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27716625/lumbar-puncture-administered-resveratrol-inhibits-stat3-activation-enhancing-autophagy-and-apoptosis-in-orthotopic-rat-glioblastomas
#9
Song Xue, Shu Xiao-Hong, Sha Lin, Bian Jie, Wang Li-Li, Gu Jia-Yao, Shi Shun, Li Pei-Nan, Wu Mo-Li, Wang Qian, Chen Xiao-Yan, Kong Qing-You, Zhang Peng, Li Hong, Liu Jia
Trans-resveratrol suppresses glioblastoma growth in vitro, but its effects on intracranial glioblastomas remain untested. Resveratrol crosses the blood-brain barrier, and lumbar puncture (LP) greatly increases its bioavailability in rat brains; therefore, we investigated the effectiveness of LP-administered resveratrol on orthotopic rat glioblastomas. Twenty-four tumor-bearing rats were separated into two groups: Group 1 receiving 100 μl saline containing 0.3% DMSO and Group 2 receiving 100 μl resveratrol (300 μM)...
October 3, 2016: Oncotarget
https://www.readbyqxmd.com/read/27713945/piceatannol-is-superior-to-resveratrol-in-promoting-neural-stem-cell-differentiation-into-astrocytes
#10
Daisuke Arai, Ryousuke Kataoka, Satoshi Otsuka, Midori Kawamura, Hiroko Maruki-Uchida, Masahiko Sai, Tatsuhiko Ito, Yoichi Nakao
Piceatannol (3,3',4',5-trans-tetrahydroxystilbene) is a polyphenolic compound abundant in the seeds of passion fruit (Passiflora edulis). Piceatannol is an analogue of resveratrol (3,4',5-trans-trihydroxystilbene) and shares the structural motif and biological activities such as activation of SIRT1. Several studies have shown that piceatannol is more potent than resveratrol. In this study, we examined the effects of piceatannol on neural stem cell differentiation into astrocytes compared with those of resveratrol...
October 12, 2016: Food & Function
https://www.readbyqxmd.com/read/27695466/expression-of-the-grape-vqsts21-gene-in-arabidopsis-confers-resistance-to-osmotic-stress-and-biotrophic-pathogens-but-not-botrytis-cinerea
#11
Li Huang, Songlin Zhang, Stacy D Singer, Xiangjing Yin, Jinhua Yang, Yuejin Wang, Xiping Wang
Stilbene synthase (STS) is a key gene in the biosynthesis of various stilbenoids, including resveratrol and its derivative glucosides (such as piceid), that has been shown to contribute to disease resistance in plants. However, the mechanism behind such a role has yet to be elucidated. Furthermore, the function of STS genes in osmotic stress tolerance remains unclear. As such, we sought to elucidate the role of STS genes in the defense against biotic and abiotic stress in the model plant Arabidopsis thaliana...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27687054/effects-of-trans-resveratrol-on-hyperglycemia-induced-abnormal-spermatogenesis-dna-damage-and-alterations-in-poly-adp-ribose-polymerase-signaling-in-rat-testis
#12
Ala Abdelali, Maie Al-Bader, Narayana Kilarkaje
Diabetes induces oxidative stress, DNA damage and alters several intracellular signaling pathways in organ systems. This study investigated modulatory effects of Trans-Resveratrol on type 1 diabetes mellitus (T1DM)-induced abnormal spermatogenesis, DNA damage and alterations in poly (ADP-ribose) polymerase (PARP) signaling in rat testis. Trans-Resveratrol administration (5mg/kg/day, ip) to Streptozotocin-induced T1DM adult male Wistar rats from day 22-42 resulted in recovery of induced oxidative stress, abnormal spermatogenesis and inhibited DNA synthesis, and led to mitigation of 8-hydroxy-2'-deoxyguanosine formation in the testis and spermatozoa, and DNA double-strand breaks in the testis...
September 27, 2016: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/27671818/therapeutic-potential-and-molecular-targets-of-piceatannol-in-chronic-diseases
#13
Young-Joon Surh, Hye-Kyung Na
Piceatannol (3,3',4,5'-tetrahydroxy-trans-stilbene; PIC) is a naturally occurring stilbene present in diverse plant sources. PIC is a hydroxylated analog of resveratrol and produced from resveratrol by microsomal cytochrome P450 1A11/2 and 1B1 activities. Like resveratrol, PIC has a broad spectrum of health beneficial effects, many of which are attributable to its antioxidative and anti-inflammatory activities. PIC exerts anticarcinogenic effects by targeting specific proteins involved in regulating cancer cell proliferation, survival/death, invasion, metastasis, angiogenesis, etc...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27643195/os-34-02-concentration-dependent-effect-of-plasma-resveratrol-on-cerebral-vasodilator-responsiveness-cvr-in-adults-with-type-2-diabetes-mellitus-t2dm
#14
Rachel Wong, Rhenan Nealon, Daniel Raederstorff, Peter Howe
OBJECTIVE: Having shown that resveratrol consumption can improve flow mediated dilation of the brachial artery, we tested its effects on CVR to hypercapnia in adults with T2DM, a risk population for cerebrovascular disease and cognitive impairments. DESIGN AND METHOD: In a double-blind crossover trial, 34 adults with T2DM consumed 0, 75, 150 and 300 mg of synthetic trans-resveratrol (one dose per week in random order). Before and 1-2 hr after dosing, transcranial Doppler ultrasound was used to assess CVR to a hypercapnic stimulus (breathing Carbogen gas for 3 min) in the middle (MCA) and posterior (PCA) cerebral arteries...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27633858/effect-of-resveratrol-on-cancer-progression-through-the-reg%C3%A2-%C3%A2-expression-pathway-in-head-and-neck-cancer-cells
#15
Shinji Mikami, Ichiro Ota, Takashi Masui, Asako Itaya-Hironaka, Ryogo Shobatake, Hideyuki Okamoto, Shin Takasawa, Tadashi Kitahara
Identification of reliable markers of chemo- and radiosensitivity and the key molecules that enhance the susceptibility of head and neck squamous cell carcinoma (HNSCC) to anticancer treatments is highly desirable. Previously, we have reported that regenerating gene (REG) Ⅲ expression was such a marker associated with an improved survival rate for HNSCC patients. In the present study, we investigated the stimulators for induction of REG Ⅲ expression using REG Ⅲ promoter assay in HNSCC cells transfected with REG Ⅲ promoter vector...
August 19, 2016: International Journal of Oncology
https://www.readbyqxmd.com/read/27623505/arbuscular-mycorrhizal-symbiosis-stimulates-key-genes-of-the-phenylpropanoid-biosynthesis-and-stilbenoid-production-in-grapevine-leaves-in-response-to-downy-mildew-and-grey-mould-infection
#16
Sébastien Bruisson, Pascale Maillot, Paul Schellenbaum, Bernard Walter, Katia Gindro, Laurence Deglène-Benbrahim
Grapevine (Vitis spp) is susceptible to serious fungal diseases usually controlled by chemical treatments. Arbuscular mycorrhizal fungi (AMF) are obligate plant symbionts which can stimulate plant defences. We investigated the effect of mycorrhization on grapevine stilbenoid defences. Vitis vinifera cvs Chasselas, Pinot noir and the interspecific hybrid Divico, on the rootstock 41B, were mycorrhized with Rhizophagus irregularis before leaf infection by Plasmopara viticola or Botrytis cinerea. Gene expression analysis showed an up-regulation of PAL, STS, and ROMT, involved in the stilbenoid biosynthesis pathway, in plant leaves, 48 h after pathogen inoculation...
November 2016: Phytochemistry
https://www.readbyqxmd.com/read/27594817/a-derivative-method-with-free-radical-oxidation-to-predict-resveratrol-metabolites-by-tandem-mass-spectrometry
#17
Wangta Liu, Yow-Ling Shiue, Yi-Reng Lin, Hugo You-Hsien Lin, Shih-Shin Liang
In this study, we demonstrated an oxidative method with free radical to generate 3,5,4'-trihydroxy-trans-stilbene (trans-resveratrol) metabolites and detect sequentially by an autosampler coupling with liquid chromatography electrospray ionization tandem mass spectrometer (LC-ESI-MS/MS). In this oxidative method, the free radical initiator, ammonium persulfate (APS), was placed in a sample bottle containing resveratrol to produce oxidative derivatives, and the reaction progress was tracked by autosampler sequencing...
October 2015: Current Analytical Chemistry
https://www.readbyqxmd.com/read/27590357/identification-of-resveratrol-derivative-3-3-4-4-5-5-hexamethoxy-trans-stilbene-as-a-novel-pro-angiogenic-small-molecule-compound
#18
ZhiQiang Chen, Lu Zhang, JingTing Yu, LiangKe Chen, Bo Zhou
The potential to promote neovascularization in ischemic tissues using exogenous agents is an attractive avenue for therapeutics. To identify novel pro-angiogenic small-molecule compound, we screened a series of resveratrol methylated derivatives and identified 3,3',4,4', 5,5'-hexamethoxy-trans-stilbene (3,3',4,4',5,5'-HMS) potently promotes proliferation, migration, invasion and tube formation of human umbilical vein VECs (HUVECs) in vitro. Furthermore, 3,3',4,4',5,5'-HMS accelerates neo-vessels sprouting of rat aortic rings ex vivo, and neovascularization of chick chorioallantoic membrane (CAM) and mouse matrigel plugs in vivo...
August 31, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27589705/red-grape-skin-polyphenols-blunt-matrix-metalloproteinase-2-and-9-activity-and-expression-in-cell-models-of-vascular-inflammation-protective-role-in-degenerative-and-inflammatory-diseases
#19
Nadia Calabriso, Marika Massaro, Egeria Scoditti, Mariangela Pellegrino, Ilaria Ingrosso, Giovanna Giovinazzo, Maria Annunziata Carluccio
Matrix metalloproteinases (MMPs) are endopeptidases responsible for the hydrolysis of various components of extracellular matrix. MMPs, namely gelatinases MMP-2 and MMP-9, contribute to the progression of chronic and degenerative diseases. Since gelatinases' activity and expression are regulated by oxidative stress, we sought to evaluate whether supplementation with polyphenol-rich red grape skin extracts modulated the matrix-degrading capacity in cell models of vascular inflammation. Human endothelial and monocytic cells were incubated with increasing concentrations (0...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27560195/resveratrol-improves-tnf-%C3%AE-induced-endothelial-dysfunction-in-a-coculture-model-of-a-caco-2-with-an-endothelial-cell-line
#20
Isabela Maia Toaldo, John Van Camp, Gerard Bryan Gonzales, Senem Kamiloglu, Marilde T Bordignon-Luiz, Guy Smagghe, Katleen Raes, Esra Capanoglu, Charlotte Grootaert
The bioactivity of trans-resveratrol (RSV), an important wine polyphenol, and of its metabolites was investigated in a more relevant setup comprising an in vitro coculture cell model that combines intestinal absorption and conjugation with changes in endothelial function, which is primarily affected in cardiovascular diseases. Caco-2 and endothelial EA.hy926 cells were grown in a coculture, and Caco-2 cells were treated with RSV in the coculture and in two different sequential setups for 4 h and 24 h. Transported metabolites were investigated by UPLC-MS/MS(E), and the effects on NO production, ROS inhibition and secretion of vascular endothelial growth factor (VEGF), interleukin-8 (IL-8) and intercellular adhesion molecule-1 (ICAM-1) were evaluated in TNF-α-activated and nonactivated endothelial cells...
October 2016: Journal of Nutritional Biochemistry
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