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trans resveratrol

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https://www.readbyqxmd.com/read/28214727/a-new-strategy-to-enhance-the-biosynthesis-of-trans-resveratrol-by-overexpressing-stilbene-synthase-gene-in-elicited-vitis-vinifera-cell-cultures
#1
Mingyu Chu, M A Pedreño, Nuria Alburquerque, Lydia Faize, Lorenzo Burgos, Lorena Almagro
In this work, transgenic lines of suspension cultured cells of Vitis vinifera cv. Monastrell containing the plasmid pMOG800-sts have been obtained. The cell growth of these transgenic cell lines decreased slightly as compared to non-transgenic suspension cultured cells, while cell viability was not affected. In addition, the elicitation with cyclodextrins and methyl jasmonate enhanced the production of trans-resveratrol, observing the highest levels of this compound in sts-expressing transgenic Vitis suspension cultured cells with the sts expression cassette in the forwards orientation...
February 8, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28194730/preparation-and-in-vitro-in-vivo-characterization-of-trans-resveratrol-nanocrystals-for-oral-administration
#2
Sandeep K Singh, Vishal Makadia, Shweta Sharma, Mamunur Rashid, Sudhir Shahi, Prabhat R Mishra, Mohammed Wahajuddin, Jiaur R Gayen
Trans -resveratrol (t-RES) is a natural polyphenolic compound with extensive therapeutic activities; however, its clinical application is circumscribed due to its poor solubility and low bioavailability. The purpose of this study was to prepare stable t-RES nanocrystals (t-RES-NCs) with different stabilizers to improve its oral bioavailability. t-RES-NCs were fabricated by the probe sonication method and optimized by particles size, poly dispersive index and zeta potential. The pharmaceutical characterization of t-RES-NCs was further performed systematically...
February 13, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28168876/characterization-of-stilbene-synthase-genes-in-mulberry-morus-atropurpurea-and-metabolic-engineering-for-the-production-of-resveratrol-in-escherichia-coli
#3
Chuanhong Wang, Shuang Zhi, Changying Liu, Fengxiang Xu, Ai Chun Zhao, Xiling Wang, Yanhong Ren, Zhengang Li, Maode Yu
Stilbenes have been recognized for their beneficial physiological effects on human health. Stilbene synthase (STS) is the key enzyme of resveratrol biosynthesis and has been studied in numerous plants. Here, four MaSTS genes were isolated and identified in mulberry (Morus atropurpurea Roxb.). The expression levels of MaSTS genes and the accumulation of trans-resveratrol, trans-oxyresveratrol and trans-mulberroside A were investigated in different plant organs. A novel co-expression system that harbored 4-coumarate:CoA ligase gene (Ma4CL) and MaSTS was established...
February 7, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28160405/distribution-of-trans-resveratrol-and-its-metabolites-after-acute-or-sustained-administration-in-mouse-heart-brain-and-liver
#4
Marie-Claude Menet, Stephanie Baron, Meryam Taghi, Remi Diestra, Delphine Dargère, Olivier Laprévote, Valérie Nivet-Antoine, Jean-Louis Beaudeux, Tatiana Bédarida, Charles-Henry Cottart
SCOPE: Trans-resveratrol is widely studied for its potentially beneficial effects on numerous disorders. It is rapidly metabolized and its metabolites can exhibit biological activity. The present study aimed to investigate whether acute or sustained trans-resveratrol administration impacted on the distribution of trans-resveratrol and its metabolites in brain, heart, and liver. METHODS AND RESULTS: We used UHPLC-Q-TOF in full-scan mode to identify and assess large numbers of resveratrol metabolites...
February 3, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28157155/disparate-effects-of-stilbenoid-polyphenols-on-hypertrophic-cardiomyocytes-in-vitro-vs-in-the-spontaneously-hypertensive-heart-failure-rat
#5
Bolanle C Akinwumi, Pema Raj, Danielle I Lee, Crystal Acosta, Liping Yu, Samuel M Thomas, Kalyanam Nagabhushanam, Muhammed Majeed, Neal M Davies, Thomas Netticadan, Hope D Anderson
Stilbenoids are bioactive polyphenols, and resveratrol (trans-3,5,40-trihydroxystilbene) is a representative stilbenoid that reportedly exerts cardioprotective actions. As resveratrol exhibits low oral bioavailability, we turned our attention to other stilbenoid compounds with a history of medicinal use and/or improved bioavailability. We determined the effects of gnetol (trans-3,5,20,60-tetrahydroxystilbene) and pterostilbene (trans-3,5-dimethoxy-40-hydroxystilbene) on cardiac hypertrophy. In vitro, gnetol and pterostilbene prevented endothelin-1-induced indicators of cardiomyocyte hypertrophy including cell enlargement and protein synthesis...
February 1, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28123505/the-effect-of-resveratrol-on-hypertension-a-clinical-trial
#6
Marios Theodotou, Konstantinos Fokianos, Alexia Mouzouridou, Cornelia Konstantinou, Andrea Aristotelous, Dafni Prodromou, Asimina Chrysikou
The aim of this clinical trial was to investigate the effects of Evelor, a micronized formulation of resveratrol (RESV; 3,5,4'-trihydroxy-trans-stilbene), in patients with primary hypertension. RESV is a stilbenoid and phytoalexin produced by several plants in response to injury or attack by pathogens, such as bacteria and fungi. Patients included in the clinical trial were split into the following two groups, based on the severity of their disease: Group A (n=46), stage I hypertension [systolic blood pressure (SBP), 140-159 mmHg; diastolic blood pressure (DBP), 90-99 mmHg] and Group B (n=51), stage II hypertension (SBP, 160-179 mmHg; DBP, 100-109 mmHg)...
January 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28067817/resveratrol-potential-therapeutic-interest-in-joint-disorders-a-critical-narrative-review
#7
REVIEW
Christelle Nguyen, Jean-François Savouret, Magdalena Widerak, Marie-Thérèse Corvol, François Rannou
Trans-resveratrol (t-Res) is a natural compound of a family of hydroxystilbenes found in a variety of spermatophyte plants. Because of its effects on lipids and arachidonic acid metabolisms, and its antioxidant activity, t-Res is considered as the major cardioprotective component of red wine, leading to the "French Paradox" health concept. In the past decade, research on the effects of resveratrol on human health has developed considerably in diverse fields such as cancer, neurodegenerative and cardiovascular diseases, and metabolic disorders...
January 6, 2017: Nutrients
https://www.readbyqxmd.com/read/28054939/effects-of-resveratrol-on-cognitive-performance-mood-and-cerebrovascular-function-in-post-menopausal-women-a-14-week-randomised-placebo-controlled-intervention-trial
#8
Hamish M Evans, Peter R C Howe, Rachel H X Wong
We tested whether chronic supplementation with resveratrol (a phytoestrogen) could improve cerebrovascular function, cognition and mood in post-menopausal women. Eighty post-menopausal women aged 45-85 years were randomised to take trans-resveratrol or placebo for 14 weeks and the effects on cognitive performance, cerebral blood flow velocity and pulsatility index (a measure of arterial stiffness) in the middle cerebral artery (using transcranial Doppler ultrasound), and cerebrovascular responsiveness (CVR) to both cognitive testing and hypercapnia were assessed...
January 3, 2017: Nutrients
https://www.readbyqxmd.com/read/28012964/resveratrol-regulates-gene-transcription-via-activation-of-stimulus-responsive-transcription-factors
#9
REVIEW
Gerald Thiel, Oliver G Rössler
Resveratrol (trans-3,4',5-trihydroxystilbene), a polyphenolic phytoalexin of grapes and other fruits and plants, is a common constituent of our diet and of dietary supplements. Many health-promoting benefits have been connected with resveratrol in the treatment of cardiovascular diseases, cancer, diabetes, inflammation, neurodegeneration, and diseases connected with aging. To explain the pleiotropic effects of resveratrol, the molecular targets of this compound have to be identified on the cellular level. Resveratrol induces intracellular signal transduction pathways which ultimately lead to changes in the gene expression pattern of the cells...
December 21, 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28001156/an-integral-study-of-cyclodextrins-as-solubility-enhancers-of-%C3%AE-methylstilbene-a-resveratrol-analogue
#10
Adrián Matencio, Samanta Hernández-García, Francisco García-Carmona, José Manuel López-Nicolás
trans-α-Methylstilbene (tMS), a resveratrol analogue, has recently been studied in a search for new bioactivities. However, such studies do not take into account that the poor solubility of tMS in aqueous solutions could affect its bioactivity. For this reason, we propose, for the first time, using cyclodextrins (CDs) as solubilizers to increase tMS solubility, in aqueous solutions. The HPLC-RP results obtained, point to a 1 : 1 stoichiometry for all the natural (α-, β- and γ-CD) and modified (HPβCD and MβCD) CDs tested...
December 21, 2016: Food & Function
https://www.readbyqxmd.com/read/27999076/hplc-identification-of-copper-ii-trans-resveratrol-complexes-in-ethanolic-aqueous-solution
#11
J Flieger, M Tatarczak-Michalewska, E Blicharska, R Świeboda, T Banach
Reversed-phase high-performance liquid chromatography assay with the diode array detector was applied for detection of trans-resveratrol complexes with copper (II). Two complexes with copper to resveratrol ratio 3:2 and 1:1 were identified in ethanolic-aqueous solutions in neutral and acidic conditions. The matrix-assisted laser desorption ionization-time of flight mass spectrometry was used for evaluation of complexes in eluate liquid fraction. The structures of complexes were modeled by Titan, Spartan and HyperChem software...
December 19, 2016: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/27995160/dataset-of-trans-resveratrol-on-diabetes-induced-abnormal-spermatogenesis-poly-adp-ribose-polymerase-1-parp1-expression-in-intra-testicular-blood-vessels-and-stage-dependent-expression-of-parp1-and-sirtuin-1-in-the-rat-testis
#12
Ala Abdelali, Maie Al-Bader, Narayana Kilarkaje
This article contains data related to the article "Effects of Trans-Resveratrol on hyperglycemia-induced abnormal spermatogenesis, DNA damage and alterations in poly (ADP-ribose) polymerase signaling in rat testis" (A. Abdelali, M. Al-Bader, N. Kilarkaje, 2016) [1]. The data are related to Resveratrol on diabetes-induced changes in blood glucose levels, body weights of rats, sperm count and motility, expression of poly (ADP-ribose) polymerase-1 (PARP1) in Leydig cells and in intratesticular blood vessels, and stage-dependent expression of PARP1 and Sirtuin 1 (SirT1) in the rat testis...
February 2017: Data in Brief
https://www.readbyqxmd.com/read/27933900/-13-c-nmr-and-lc-ms-profiling-of-stilbenes-from-elicited-grapevine-hairy-root-cultures
#13
Leo-Paul Tisserant, Jane Hubert, Michelle Lequart, Nicolas Borie, Nicolas Maurin, Serge Pilard, Philippe Jeandet, Aziz Aziz, Jean-Hugues Renault, Jean-Marc Nuzillard, Christophe Clément, Michèle Boitel-Conti, Eric Courot
Resveratrol and related oligostilbenes are defense molecules produced by grapevine in response to stresses including various elicitors or signal molecules. Together with their prominent role in planta, these compounds have been the center of much attention in recent decades due to their pharmacological properties. The cost-effective production of resveratrol derivatives such as viniferins or more structurally complex stilbene oligomers remains a challenging task. In this study, the chemical diversity of stilbenes produced by Vitis vinifera Pinot Noir hairy roots was investigated after elicitation for 4 days with a mixture of methyl jasmonate (100 μM) and cyclodextrins (50 mM)...
November 23, 2016: Journal of Natural Products
https://www.readbyqxmd.com/read/27916959/a-molecular-electron-density-theory-study-of-the-chemical-reactivity-of-cis-and-trans-resveratrol
#14
Juan Frau, Francisco Muñoz, Daniel Glossman-Mitnik
The chemical reactivity of resveratrol isomers with the potential to play a role as inhibitors of the nonenzymatic glycation of amino acids and proteins, both acting as antioxidants and as chelating agents for metallic ions such as Cu, Al and Fe, have been studied by resorting to the latest family of Minnesota density functionals. The chemical reactivity descriptors have been calculated through Molecular Electron Density Theory encompassing Conceptual DFT. The active sites for nucleophilic and electrophilic attacks have been chosen by relating them to the Fukui function indices, the dual descriptor f ( 2 ) ( r ) and the electrophilic and nucleophilic Parr functions...
December 1, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27904389/performance-of-different-natural-antioxidant-compounds%C3%A2-in-frying-oil
#15
Buket Aydenız, Emin Yilmaz
In this study, the natural green tea extract, purified lycopene, purified resveratrol and purified γ-oryzanol were added into peanut oil and their antioxidant performances were evaluated during frying. Moreover, the sensory properties of fried dough were evaluated to determine the consumption feasibility. All natural antioxidants led to significant increase in the stability of the oil samples. The ranges of measurements in the treatment groups were as follows: free acidity 0.1-2.9 g of oleic acid per 100 g of oil, conjugated dienes 0...
March 2016: Food Technology and Biotechnology
https://www.readbyqxmd.com/read/27895698/combinations-of-bio-active-dietary-constituents-affect-human-white-adipocyte-function-in-vitro
#16
Ines Warnke, Johan W E Jocken, Rotraut Schoop, Christine Toepfer, Regina Goralczyk, Joseph Schwager
BACKGROUND: Specific bio-active dietary compounds modulate numerous metabolic processes in adipose tissue (AT), including pre-adipocyte proliferation and differentiation. AT dysfunction, rather than an increased fat mass per se, is strongly associated with the development of insulin resistance and is characterized by impaired adipogenesis, hypertrophic adipocytes, inflammation, and impairments in substrate metabolism. A better understanding of mechanisms underlying AT dysfunction may provide new strategies for the treatment of obesity-associated metabolic diseases...
2016: Nutrition & Metabolism
https://www.readbyqxmd.com/read/27882602/the-resveratrol-derivatives-trans-3-5-dimethoxy-4-fluoro-4-hydroxystilbene-and-trans-2-4-5-trihydroxystilbene-decrease-oxidative-stress-and-prolong-lifespan-in-caenorhabditis-elegans
#17
Nadine Fischer, Christian Büchter, Karoline Koch, Sabrina Albert, René Csuk, Wim Wätjen
OBJECTIVES: Resveratrol (trans-3,4',5-trihydroxystilbene (1)) was previously shown to extend the lifespan of different model organisms. However, its pharmacological efficiency is controversially discussed. Therefore, the bioactivity of four newly synthesized stilbenes (trans-3,5-dimethoxy-4-fluoro-4'-hydroxystilbene (3), trans-4'-hydroxy-3,4,5-trifluorostilbene (4), trans-2,5-dimethoxy-4'-hydroxystilbene (5), trans-2,4',5-trihydroxystilbene (6)) was compared to (1) and pterostilbene (trans-3,5-dimethoxy-4'-hydroxystilbene (2)) in the established model organism Caenorhabditis elegans...
January 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/27854074/resveratrol-and-its-methoxy-derivatives-modulate-the-expression-of-estrogen-metabolism-enzymes-in-breast-epithelial-cells-by-ahr-down-regulation
#18
Barbara Licznerska, Hanna Szaefer, Marcin Wierzchowski, Hanna Sobierajska, Wanda Baer-Dubowska
Our earlier studies have shown that compared to resveratrol, its analogs with ortho-methoxy substituents exert stronger antiproliferative and proapoptotic activity. Since estrogens are considered the major risk factors of breast carcinogenesis, the aim of this study was to evaluate the effect of 3,4,2'-trimethoxy (3MS), 3,4,2',4'-tetramethoxy (4MS), and 3,4,2',4',6'-pentamethoxy (5MS) trans-stilbenes on the constitutive expression of the enzymes involved in estrogen metabolism, as well as receptors: AhR and HER2 in breast epithelial cell line MCF10A...
January 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/27834152/research-problems-associated-with-resveratrol-trans-3-5-4-trihydroxystilbene-rsv-and-various-strategies-to-overcome-those-problems-review
#19
Monika, Garg R, Sardana S K
BACKGROUND: Resveratrol belonging to stilbene family has emerged as a leading candidate for enhancing the health span by potentially decreasing the aging process and reducing chronic diseases. OBJECTIVE: The aim of this review is to focus on various studies related to chemical composition l, pharmacological activities, bioavailability problems associated with resveratrol. In addition, it includes section discussing the challenges associated with drug and strategies to improve resveratrol solubility, stability and bioavailability...
November 9, 2016: Current Drug Delivery
https://www.readbyqxmd.com/read/27818239/determination-of-trans-resveratrol-and-its-metabolites-in-rat-serum-using-liquid-chromatography-with-high-resolution-time-of-flight-mass-spectrometry
#20
Jana Rousova, Kari Kusler, Duminda Liyanage, Mary Leadbetter, Nagaraju Dongari, Ke K Zhang, Alexei Novikov, Edward R Sauter, Alena Kubátová
In this study we developed a sensitive method using high performance liquid chromatography (HPLC) coupled to electrospray ionization (ESI) with high resolution time of flight (TOF) mass spectrometry (MS) for the determination of naturally occurring antioxidant trans-resveratrol (3,5,4'-trihydroxy-trans-stilbene, RES). This method enabled an investigation of a relationship between tumor growth in rats and concentration of RES and its primary metabolites, trans-resveratrol-3-O-sulfate-3-O-sulfate (R3S) and trans-resveratrol-3-O-β-d-glucuronide (R3G), in rat serum after RES exposure (5 or 25mg/kg/day)...
December 15, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
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