keyword
MENU ▼
Read by QxMD icon Read
search

hesperetin

keyword
https://www.readbyqxmd.com/read/29138782/vasorelaxant-activity-of-twenty-one-physiologically-relevant-poly-phenolic-metabolites-on-isolated-mouse-arteries
#1
E Van Rymenant, C Grootaert, K Beerens, P W Needs, P A Kroon, A Kerimi, G Williamson, R García-Villalba, A González-Sarrías, F Tomas-Barberan, J Van Camp, J Van de Voorde
Polyphenols are beneficial for health, but are metabolised after consumption. We compared the vasorelaxant capacity of twenty-one physiologically relevant polyphenol metabolites in isolated mouse arteries. Hesperetin, urolithins and ferulic acid-4-O-sulfate - not their glucuronidated forms or ferulic acid - caused vasorelaxation. Therefore, we advise the use of relevant conjugates in future mechanistic research.
November 15, 2017: Food & Function
https://www.readbyqxmd.com/read/29136946/neuroprotective-effect-of-hesperetin-and-nano-hesperetin-on-recognition-memory-impairment-and-the-elevated-oxygen-stress-in-rat-model-of-alzheimer-s-disease
#2
Elham Kheradmand, Akbar Hajizadeh Moghaddam, Mahboobeh Zare
Alzheimer disease (AD) is a progressive dementia affecting a large proportion of the aging population. There is evidence that brain tissue in patients with AD is exposed to oxidative stress during the course of the disease. Hesperetin (Hst) is a natural flavonoid, which has been reported to exert various biological activities such as antioxidant and anti-inflammatory effect. The present study aimed to investigate the effects of hesperetin and nano-hesperetin on neurobehavioral activity and superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GRx) and catalase (CAT) enzymes activity, malondialdehyde (MDA) and glutathione (GSH) levels in hippocampal area of rats in an experimental model of AD...
November 9, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29115547/preventive-effect-of-hesperidin-modulates-inflammatory-responses-and-antioxidant-status-following-acute-myocardial-infarction-through-the-expression-of-ppar%C3%A2-%C3%AE-and-bcl%C3%A2-2-in-model-mice
#3
Chunying Meng, Zeheng Guo, Dagang Li, Hanwei Li, Jianbin He, Dingguo Wen, Bin Luo
Hesperetin is the main pharmacological ingredient of fruit of the citrus family, rutaceae. It is a flavanone, which has potent antioxidation and anti‑inflammatory activities. The present study investigated the preventive effect of hesperidin in the modulation of acute myocardial infarction (AMI)‑induced inflammatory responses and antioxidant status in a mouse model. The levels of creatine kinase‑MB, tumor necrosis factor (TNF‑α), interleukin (IL)‑1β, IL‑6, monocyte chemoattractant protein 1 (MCP‑1), intercellular adhesion molecule 1 (ICAM‑1), malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD) and caspase‑3/9 were measured using ELISA kits...
November 6, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29080465/antihyperglycemic-effect-of-hesperetin-a-citrus-flavonoid-extenuates-hyperglycemia-and-exploring-the-potential-role-in-antioxidant-and-antihyperlipidemic-in-streptozotocin-induced-diabetic-rats
#4
Revathy Jayaraman, Srinivasan Subramani, Shahul Hameed Sheik Abdullah, Muruganathan Udaiyar
Diabetes is the major health problem in modern civilization which occurs due to inadequate metabolism of carbohydrate and lipid could cause tremendous changes in the metabolic activities of liver. In this study, we investigated the antihyperglycemic, antioxidant and antihyperlipidemic effects of hesperetin, a citrus flavonoid against streptozotocin (STZ)-induced experimental rats. To stimulate diabetes mellitus, rats were injected with STZ intraperitoneally at a single dose of 45mg/kg. STZ induced rats showed marked increase in the level of plasma glucose and significant reduction in the level of plasma insulin...
October 31, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29042968/hesperetin-alleviates-renal-interstitial-fibrosis-by-inhibiting-tubular-epithelial-mesenchymal-transition-in-vivo-and-in-vitro
#5
Hong-Wei Wang, Lei Shi, Yan-Ping Xu, Xing-Ya Qin, Qi-Zhi Wang
Hesperetin (HES) is a flavonoid that has been reported to exert protective effects against cardiac remodeling, lung fibrosis and hepatic fibrosis. However, reports on the effects and potential mechanisms of HES in renal fibrosis are limited. In the present study, a unilateral ureteric obstruction (UUO) mouse model and a transforming growth factor (TGF)-β1-activated normal rat kidney (NRK)-52E cell model were established. HES was subsequently administered to these models to evaluate its anti-fibrotic effects and potential underlying mechanisms of action...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29042280/biochemical-and-biophysical-characterization-of-a-mycoredoxin-protein-glutaredoxin-a1-from-corynebacterium-pseudotuberculosis
#6
Raphael J Eberle, Liege A Kawai, Fabio R de Moraes, Ljubica Tasic, Raghuvir K Arni, Monika A Coronado
Glutaredoxin A1 from Corynebacterium pseudotuberculosis was shown to be a mycoredoxin protein. In this study, we established a process to overexpress and purify glutaredoxin A1. The aim of this study was the investigation of the Glutaredoxin A1 from C. pseudotuberculosis behavior under different redox environments and the identification of lead molecules, which can be used for specific inhibitor development for this protein family. A quantitative assay was performed measuring the rate of insulin reduction spectrophotometrically at 640nm through turbidity formation from the precipitation of the free insulin...
October 16, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29032208/chitosan-based-nano-formulation-enhanced-the-anticancer-efficacy-of-hesperetin
#7
Lizha Mary, Balaji Sadhasivam, Kanagaraj Palaniyandi, Thangavel Muthuswamy, Ilangovan Ramachandran, Anandhan Balakrishnan, Surajit Pathak, Shoba Narayan, Satish Ramalingam
Cancer is one of the major causes of increased morbidity and mortality in modern society. Colorectal cancer is the third leading cause for cancer related death worldwide. Current chemotherapeutics are not very effective and have severe side effects. Hesperetin is a bioflavonoid from citrus fruits and its clinical use is restricted because of the poor water solubility. Folate receptor is over expressed in various cancer cells. In this regard, we have synthesized the Chitosan Folate Hesperetin nanoparticle (CFH) by covalently conjugating folic acid with chitosan molecules...
October 12, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29029741/enantioseparation-of-single-layer-native-cyclodextrin-chiral-stationary-phases-effect-of-cyclodextrin-orientation-and-a-modeling-study
#8
Xiaoxuan Li, Xiaobin Yao, Yin Xiao, Yong Wang
A novel native cyclodextrin (CD) chiral stationary phase (CSP) with single triazole-bridge at CD C2 position (CSP1) was prepared by anchoring mono(2(A)-azido-2(A)-deoxy)-β-CD onto alkynyl silica via click chemistry. The effect of CD orientation on single layer CD-CSP's enantioseparation was comprehensively investigated using CSP1 (reversed orientation) and our previously reported CSP2 (C6 single triazole-bridge, normal orientation) as well as a commercial CD-CSP (Cyclobond I 2000, hybrid orientation) by separating several groups of analytes in chiral high performance liquid chromatography...
October 16, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29023372/parp-inhibition-by-flavonoids-induced-selective-cell-killing-to-brca2-deficient-cells
#9
Cathy Su, Alexis H Haskins, Chisato Omata, Yasushi Aizawa, Takamitsu A Kato
High consumption of dietary flavonoids might contribute to a reduction of cancer risks. Quercetin and its glycosides have PARP inhibitory effects and can induce selective cytotoxicity in BRCA2-deficient cells by synthetic lethality. We hypothesized that common flavonoids in diet naringenin, hesperetin and their glycosides have a similar structure to quercetin, which might have comparable PARP inhibitory effects, and can induce selective cytotoxicity in BRCA2-deficient cells. We utilized Chinese hamster V79 wild type, V-C8 BRCA2-deficient and its gene-complemented cells...
October 12, 2017: Pharmaceuticals
https://www.readbyqxmd.com/read/28962151/hesperetin-protects-against-inflammatory-response-and-cardiac-fibrosis-in-postmyocardial-infarction-mice-by-inhibiting-nuclear-factor-%C3%AE%C2%BAb-signaling-pathway
#10
Bing Wang, Lianghai Li, Ping Jin, Mengqiu Li, Jianguo Li
Cardiac inflammation and cardiac fibrosis are important parts of cardiac remodeling following myocardial infarction (MI), which may be the basic mechanisms of the development of chronic heart failure. The nuclear factor (NF)-κB signaling pathway promotes cardiac inflammation and fibrosis. It has reported that hesperetin inhibits cardiac remodeling induced by pressure overload in mice. However, it has remained elusive whether and how hesperetin has a role in cardiac fibrosis post-MI. Therefore, a mouse model of MI was established by left anterior descending coronary artery ligation...
September 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28956456/production-of-drug-nanosuspensions-effect-of-drug-physical-properties-on-nanosizing-efficiency
#11
Tao Liu, Rainer H Müller, Jan P Möschwitzer
Objective Drug nanosuspension is one of the established methods to improve the bioavailability of poorly soluble drugs. Drug physical properties aspect (morphology, solid state, starting size et al) is a critical parameter determining the production efficiency. Some drug modification approaches such as spray-drying were proved to improve the millability of drug powders. However, the mechanism behind those improved performances is unclear. This study is to systematically investigate the influence of those physical properties...
September 28, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28954539/gontscharovia-popovii-a-new-source-of-carvacrol-its-polyphenolic-constituents-essential-oil-analysis-total-phenolic-content-and-antioxidant-activity
#12
Faraneh Zareiyan, Vahid Rowshan, Atefeh Bahmanzadegan, Ahmad Hatami
The experiment was carried out using the shadow-dried aerial parts including leaves and shoots of Gontscharovia popovii collected in Fars province in order to investigate the polyphenolic compositions, antioxidant activity, total phenolic content and essential oil constituents. The result showed IC50 of 395.77 μg mL(-1) and total phenolic content of about 20.01 mg g(-1) gallic acid equivalent dry weight. It also showed a wild range of polyphenols such as; Gallic acid, catechin, chloregenic acid, rutin, vanillin, trans-Ferulic acid, sinapic acid, coumarin, hesperedin, quercetin, hesperetin, eugenol and carvacrol as the main detected polyphenols...
September 28, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28942652/polyphenols-from-blossoms-of-citrus-aurantium-l-var-amara-engl-show-significant-anti-complement-and-anti-inflammatory-effects
#13
Chun-Yan Shen, Jian-Guo Jiang, Chun-Ling Huang, Wei Zhu, Chao-Yang Zheng
Citrus aurantium L. var. amara Engl. (CAVA) was traditionally used as a digestant or expectorant in China. Crude polyphenols (CAVAP-W) extracted from blossoms of CAVA were mainly composed of eriocitrin/neoeriocitrin, eriocitrin/neoeriocitrin, rhoifolin, hesperidin, naringin, rutin, veronicastroside, neohesperidin, and hesperetin by LC-MS analysis. CAVAP-W showed significant anticomplement and anti-inflammatory effects. Due to the close relationship between anticomplement and anti-inflammatory activity, the anti-inflammatory effect was further investigated and the results showed that CAVAP-W significantly suppressed production of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), interleukin-1beta (IL-1β), and mRNA expression of inducible nitric oxide synthase (iNOS), IL-6, TNF-α, IL-1β, and cyclooxygenase-2 (COX-2) in lipopolysaccharides-stimulated RAW264...
October 9, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28923363/anti-inflammatory-effects-of-flavonoids-in-neurodegenerative-disorders
#14
Carmela Spagnuolo, Stefania Moccia, Gian Luigi Russo
Neuroinflammation is one of the main mechanisms involved in the progression of several neurodegenerative diseases, such as Parkinson, Alzheimer, multiple sclerosis, amyotrophic lateral sclerosis and others. The activation of microglia is the main feature of neuroinflammation, promoting the release of pro-inflammatory cytokines and resulting in the progressive neuronal cell death. Natural compounds, such as flavonoids, possess neuroprotective potential probably related to their ability to modulate the inflammatory responses involved in neurodegenerative diseases...
September 7, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28883473/identification-of-aspergillus-fumigatus-udp-galactopyranose-mutase-inhibitors
#15
Julia S Martin Del Campo, Meital Eckshtain-Levi, Nancy J Vogelaar, Pablo Sobrado
Aspergillus fumigatus is an opportunistic human pathogen responsible for deadly, invasive infections in immunocompromised patients. The A. fumigatus cell wall is a complex network of polysaccharides among them galactofuran, which is absent in humans. UDP-galactopyranose mutase (UGM) catalyzes the conversion of UDP-galactofuranose (UDP-Galf) to UDP-galactopyranose (UDP-Galp) and is an important virulence factor. UGM is a flavin-dependent enzyme that requires the reduced flavin for activity; flavin reduction is achieved by reaction with NADPH...
September 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28839359/mechanism-of-fructus-aurantii-flavonoids-promoting-gastrointestinal-motility-from-organic-and-inorganic-endogenous-substances-combination-point-of-view
#16
Shuai Wang, Yong-Rui Bao, Tian-Jiao Li, Ting Yu, Xin Chang, Guan-Lin Yang, Xian-Sheng Meng
BACKGROUND: Fructus Aurantii (FA) derived from the dried, and unripe fruit of Citrus aurantium L. is one of the commonly used traditional Chinese medicines to treat gastrointestinal motility dysfunction diseases. According to the literature research, FA flavonoids (FAF) are important active ingredients of FA promoting gastrointestinal motility, but the exact material basis and mechanism of action are still not very clear. OBJECTIVE: This experiment was designed to illustrate the material basis of FAF promoting gastrointestinal motility and explore the mechanism of action from an organic and inorganic combination point of view...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28820428/pharmacokinetic-analysis-of-an-oral-multicomponent-joint-dietary-supplement-phycox-%C3%A2-in-dogs
#17
Stephanie E Martinez, Ryan Lillico, Ted M Lakowski, Steven A Martinez, Neal M Davies
Despite the lack of safety, efficacy and pharmacokinetic (PK) studies, multicomponent dietary supplements (nutraceuticals) have become increasingly popular as primary or adjunct therapies for clinical osteoarthritis in veterinary medicine. Phycox(®) is a line of multicomponent joint support supplements marketed for joint health in dogs and horses. Many of the active constituents are recognized anti-inflammatory and antioxidant agents. Due to a lack of PK studies in the literature for the product, a pilot PK study of select constituents in Phycox(®) was performed in healthy dogs...
August 18, 2017: Pharmaceutics
https://www.readbyqxmd.com/read/28774689/design-synthesis-and-biological-evaluation-of-hesperetin-derivatives-as-potent-anti-inflammatory-agent
#18
Hai-Wen Ding, Ai-Ling Huang, Yi-Long Zhang, Bo Li, Chen Huang, Tao-Tao Ma, Xiao-Ming Meng, Jun Li
A flavonoid hesperetin is reported to have a variety of biological activities, including anticancer, antiviral, antioxidant, neuroprotective and anti-inflammatory properties. Thirty-one novel hesperetin derivatives were designed, synthesized and evaluated for anti-inflammatory activity using RAW264.7 cells and CCl4-induced acute liver injury model. Among these compounds, 5b displayed the excellent anti-inflammatory activity on decreasing NO, IL-6 and TNF-α both in vitro and vivo. In addition, 5b could also reduce the release of NO, IL-6 and TNF-α production by LPS stimulated RAW 264...
September 2017: Fitoterapia
https://www.readbyqxmd.com/read/28753501/the-effect-of-active-components-from-citrus-fruits-on-dentin-mmps
#19
Zhengya Liu, Fang Li, Ling Zhang, Haohan Yu, Fan Yu, Jihua Chen
OBJECTIVES: This study was aimed to evaluate the anti-matrix metalloproteinases (MMPs) ability of active components from citrus fruits (hesperetin: Hst, hesperidin: Hsd and naringenin: Nge). METHODS: Inactivation effects of citrus flavonoids (Hst, Hsd, Nge) at different concentrations on soluble collagenase were measured using a fluorometric assay. Matrix-bound endogenous MMPs activity was evaluated via dry mass loss and hydroxyproline (HYP) release of demineralized human dentin...
July 20, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28747329/bioavailability-of-orange-juice-poly-phenols-the-impact-of-short-term-cessation-of-training-by-male-endurance-athletes
#20
Gema Pereira-Caro, Thelma Polyviou, Iziar A Ludwig, Ana-Maria Nastase, José Manuel Moreno-Rojas, Ada L Garcia, Dalia Malkova, Alan Crozier
Background: Physical exercise has been reported to increase the bioavailability of citrus flavanones.Objective: We investigated the bioavailability of orange juice (OJ) (poly)phenols in endurance-trained males before and after cessation of training for 7 d.Design: Ten fit, endurance-trained males, with a mean ± SD maximal oxygen consumption of 58.2 ± 5.3 mL · kg(-1) · min(-1), followed a low (poly)phenol diet for 2 d before drinking 500 mL of OJ containing 398 μmol of (poly)phenols, of which 330 μmol was flavanones...
September 2017: American Journal of Clinical Nutrition
keyword
keyword
104018
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"