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https://www.readbyqxmd.com/read/29763690/the-citrus-flavonone-hesperetin-attenuates-the-nuclear-translocation-of-aryl-hydrocarbon-receptor
#1
Yan Qin Tan, Leo Clement Chiu-Leung, Shu-Mei Lin, Lai K Leung
The environmental polycyclic aromatic hydrocarbons (PAH) and dioxins are carcinogens and their adverse effects have been largely attributed to the activation of AhR. Hesperetin is a flavonone found abundantly in citrus fruits and has been shown to be a biologically active agent. In the present study, the effect of hesperetin on the nuclear translocation of AhR and the downstream gene expression was investigated in MCF-7 cells. Confocal microscopy indicated that 7, 12-dimethylbenz[α]anthracene (DMBA) or 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) -induced nuclear translocation of AhR was deterred by hesperetin treatment...
May 12, 2018: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29723508/inhibition-of-pp2a-by-hesperetin-contributes-to-akt-and-erk1-2-activation-in-primary-cortical-neurons
#2
David Vauzour, Simone Corsini, Michael Müller, Jeremy P E Spencer
Flavonoids and their metabolites are well reported to modulate the activation/phosphorylation of various cellular kinases, such as ERK1/2 and JNK, although the mechanism by which they do so is unclear. In this study, we investigated the impact of flavanones on the activation of PI3K/Akt and ERK1/2 and determine whether this is mediated, in part, by the inhibition of phosphatases. Primary cortical neurons were exposed to physiological concentrations of hesperetin and the phosphorylation status of the kinases PI3K/Akt and ERK1/2 and the phosphatases PP2A and PTEN were assessed by immunoblotting after 30 min...
April 30, 2018: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29698678/citrus-bioflavonoids-possess-dipeptidyl-peptidase-4-inhibition-activity-similar-to-gliptin-antidiabetic-medication
#3
Ankit Gupta, Glenn A Jacobson, John R Burgess, Herbert F Jelinek, David S Nichols, Christian K Narkowicz, Hayder A Al-Aubaidy
This study demonstrates the Dipeptidyl peprtidase-4 (DPP-4) inhibition activity of citrus bioflavonoid nutraceuticals as compared to known gliptins. Citrus bioflavonoid standards and three commercially available citrus bioflavonoid supplements (Thompson's Super Bioflavonoid Complex® (SB), Ethical Nutrient Citrus Plus Vitamin C® (EN), and Country Life Citrus Bioflavonoid & Rutin® (CB)) were considered in this study. Ultra-performance liquid chromatography-mass spectrometry (UPLC-MS) analysis was undertaken to identify the citrus bioflavonoids present in each supplement and the DPP-4 inhibitory activity was determined using the DPP-4 fluorometric assay...
April 23, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29674047/magnetic-molecularly-imprinted-polymer-for-the-selective-extraction-of-hesperetin-from-the-dried-pericarp-of-citrus-reticulata-blanco
#4
Dan-Dan Wang, Die Gao, Wan-Jun Xu, Fan Li, Man-Ni Yin, Qi-Feng Fu, Zhi-Ning Xia
In present study, novel magnetic molecularly imprinted polymers for hesperetin were successfully prepared by surface molecular imprinting method using functionalized Fe3 O4 particles as the magnetic cores. Hesperetin as the template, N-Isopropylacrylamide as the functional monomer, ethylene glycol dimethyl acrylate as the crosslinker, 2,2-azobisisobutyonnitrile as initiator and acetonitrile-methanol (3:1, v/v) as the porogen were applied in the preparation process. Fourier transform infrared spectroscopy, scanning electron microscopy, transmission electron microscope, x-ray diffraction and vibrating sample magnetometry were applied to characterize the magnetic molecularly imprinted polymers...
July 1, 2018: Talanta
https://www.readbyqxmd.com/read/29626522/the-acute-effects-of-citrus-flavanones-on-the-metabolism-of-glycogen-and-monosaccharides-in-the-isolated-perfused-rat-liver
#5
Gilson Soares do Nascimento, Renato Polimeni Constantin, Eduardo Hideo Gilglioni, Cristiane Vizioli de Castro Ghizoni, Adelar Bracht, Karina Sayuri Utsunomiya, Nair Seiko Yamamoto, Emy Luiza Ishii-Iwamoto, Jorgete Constantin, Rodrigo Polimeni Constantin
Citrus flavanones are often linked to their antihyperglycemic properties. This effect may be in part due to the inhibition of hepatic gluconeogenesis through different mechanisms. One of the possible mechanisms appears to be impairment of oxidative phosphorylation, which may also interfere with glycogen metabolism. Based on these facts, the purpose of the present study was to investigate the effects of three citrus flavanones on glycogenolysis in the isolated perfused rat liver. Hesperidin, hesperetin, and naringenin stimulated glycogenolysis and glycolysis from glycogen with concomitant changes in oxygen uptake...
April 4, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29617563/protein-surface-structural-recognition-in-inactive-areas-a-new-immobilization-strategy-for-acetylcholinesterase
#6
Jianxiong Diao, Xiaolu Yu, Lin Ma, Yuanqing Li, Ying Sun
This work reported a new method of design for the immobilization of acetylcholinesterase (AChE) based on its molecular structure to improve its sensitivity and stability. The immobilization binding site on the surface of AChE was determined using MOLCAD's multi-channel functionality. Then, 11 molecules ((+)-catechin, (-)-epicatechin, (-)-gallocatechin, hesperetin, naringenin, quercetin, taxifolin, (-)-epicatechin gallate, flupirtine, atropine, and hyoscyamine) were selected from the ZINC database (about 50000 molecules) as candidate affinity ligands for AChE...
April 4, 2018: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29576857/-citrus-aurantium-naringenin-prevents-osteosarcoma-progression-and-recurrence-in-the-patients-who-underwent-osteosarcoma-surgery-by-improving-antioxidant-capability
#7
Lirong Zhang, Xiaohua Xu, Tiechao Jiang, Kunzhe Wu, Chuanbo Ding, Zhen Liu, Xuanhe Zhang, Tianhua Yu, Changlong Song
Citrus aurantium is rich in flavonoids, which may prevent osteosarcoma progression, but its related molecular mechanism remains unclear. Flavonoids were extracted from C. aurantium and purified by reparative HPLC. Each fraction was identified by using electrospray ionisation mass spectrometry (ESI-MS). Three main components (naringin, naringenin, and hesperetin) were isolated from C. aurantium . Naringenin inhibited the growth of MG-63 cells, whereas naringin and hesperetin had no inhibitory function on cell growth...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29533635/homoisoflavonoids-are-potent-glucose-transporter-2-glut2-inhibitors-a-potential-mechanism-for-the-glucose-lowering-properties-of-polygonatum-odoratum
#8
Huijun Wang, Mark I Fowler, David J Messenger, Leon A Terry, Xuelan Gu, Luxian Zhou, Ruimin Liu, Juan Su, Songshan Shi, Jose Juan Ordaz-Ortiz, Guoping Lian, Mark J Berry, Shunchun Wang
Foods of high carbohydrate content such as sucrose or starch increase postprandial blood glucose concentrations. The glucose absorption system in the intestine comprises two components: sodium-dependent glucose transporter-1 (SGLT1) and glucose transporter 2 (GLUT2). Here five sappanin-type (SAP) homoisoflavonoids were identified as novel potent GLUT2 inhibitors, with three of them isolated from the fibrous roots of Polygonatum odoratum (Mill.) Druce. SAP homoisolflavonoids had a stronger inhibitory effect on 25 mM glucose transport (41...
March 19, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29513037/lagoecia-cuminoides-l-its-antioxidant-activity-and-polyphenolic-constituents-from-iran
#9
Atefeh Bahmanzadegan, Vahid Rowshan, Faraneh Zareiyan, Ahmad Hatami
Lagoecia cuminoides L. belongs to the family of Umbelliferae (Apiaceae), and known also as common wild cumin. The aerial parts of L. cuminoides were collected at the flowering stage and dried, then the methanolic extract was analyzed for polyphenol compounds identified by HPLC-DAD and antioxidant activity (DPPH(2,2-diphenyl-1-picrylhydrazyl) radical scavenging assay). It was found that the predominant phenolic constituents were chlorogenic acid, hesperidin, rosmarinic acid, hesperetin and vanillin. The antioxidant activity of methanolic extract from L...
March 7, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29497429/functional-characterization-of-a-flavonoid-glycosyltransferase-in-sweet-orange-citrus-sinensis
#10
Xiaogang Liu, Cailing Lin, Xiaodi Ma, Yan Tan, Jiuzhao Wang, Ming Zeng
Fruits of sweet orange ( Citrus sinensis ), a popular commercial Citrus species, contain high concentrations of flavonoids beneficial to human health. These fruits predominantly accumulate O -glycosylated flavonoids, in which the disaccharides [neohesperidose (rhamnosyl-α-1,2-glucose) or rutinose (rhamnosyl-α-1,6-glucose)] are linked to the flavonoid aglycones through the 3- or 7-hydroxyl sites. The biotransformation of the flavonoid aglycones into O -rutinosides or O -neohesperidosides in the Citrus plants usually consists of two glycosylation reactions involving a series of uridine diphosphate-sugar dependent glycosyltransferases (UGTs)...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29477239/advanced-glycation-end-products-in-the-pathogenesis-of-chronic-kidney-disease
#11
REVIEW
Naila Rabbani, Paul J Thornalley
Advanced glycation end products (AGEs) are stable posttranslational modifications of proteins formed by the spontaneous reaction with glucose and related metabolites. Important AGEs quantitatively are methylglyoxal (MG)-derived hydroimidazolone MG-H1, Nε -carboxymethyl-lysine (CML), and glucosepane. They contribute to the development of chronic kidney disease (CKD). Cellular proteolysis of AGE-modified proteins forms AGE free adducts, glycated amino acids, which are cleared by the kidneys and excreted in urine...
April 2018: Kidney International
https://www.readbyqxmd.com/read/29451355/a-critical-evaluation-of-in-vitro-hesperidin-2s-bioavailability-in-a-model-combining-luminal-microbial-digestion-and-caco-2-cell-absorption-in-comparison-to-a-randomized-controlled-human-trial
#12
Evelien Van Rymenant, Bouke Salden, Stefan Voorspoels, Griet Jacobs, Bart Noten, Judit Pitart, Sam Possemiers, Guy Smagghe, Charlotte Grootaert, John Van Camp
SCOPE: Bioavailability strongly determines polyphenol bioactivity, and is strongly influenced by food matrix, enzymatic and microbial degradation, and gastrointestinal absorption. To avoid human trials for pre-screening of polyphenol bioavailability, studies have focused on in vitro model development. Nevertheless, their predictive value for bioavailability can be questioned. METHOD AND RESULTS: We used the orange flavonoid hesperidin 2S to validate a model combining digestion in the simulator of the human intestinal microbial ecosystem (SHIME) and Caco-2 cell transport, with a human intervention study...
April 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29389550/vegetable-fruit-and-phytonutrient-consumption-patterns-in-taiwan
#13
Wen-Harn Pan, Nai-Hua Yeh, Ray-Yu Yang, Wei-Hsuan Lin, Wan-Chen Wu, Wen-Ting Yeh, Mi-Kyung Sung, Haeng-Shin Lee, Sue-Joan Chang, Ching-Jang Huang, Bi-Fong Lin, Meng-Tsan Chiang
Phytonutrients may play important roles in human health and yet only recently a few studies have described phytonutrient consumption patterns, using data obtained from daily consumption methods. We aimed to estimate the phytonutrient content in Taiwanese diets and analyzed main food sources of 10 major phytonutrients. In this study, food items and dietary data gathered with the 24-hour dietary recall from 2908 participants in the 2005-2008 Nutrition and Health Survey in Taiwan were used to create a food phytonutrient database with 933 plant-based foods through integrating database, literature search, and chemical analysis and to appraise phytonutrient consumption status of participants...
January 2018: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/29373678/design-and-evaluation-of-a-novel-flavonoid-based-radioprotective-agent-utilizing-monoglucosyl-rutin
#14
Yasushi Aizawa, Shigeaki Sunada, Hirokazu Hirakawa, Akira Fujimori, Takamitsu A Kato, Mitsuru Uesaka
In this study, three novel flavonoid composite materials, created by combining an aglycone [quercetin (QUE), hesperetin (HES) or naringenin (NAR)] with monoglucosyl rutin (MGR), were designed to test for improved radioprotectivity compared with that provided by administration of MGR alone. Aglycone in the MGR-composite state was highly soluble in water, compared with aglycone alone dissolved in dimethyl sulfoxide or distilled water. The antioxidant activity of the three flavonoid composites was as high as that of MGR only...
January 24, 2018: Journal of Radiation Research
https://www.readbyqxmd.com/read/29361187/the-c-s-a-gene-system-regulates-hull-pigmentation-and-reveals-evolution-of-anthocyanin-biosynthesis-pathway-in-rice
#15
Xingming Sun, Zhanying Zhang, Chao Chen, Wei Wu, Nannan Ren, Conghui Jiang, Jianping Yu, Yan Zhao, Xiaoming Zheng, Qingwen Yang, Hongliang Zhang, Jinjie Li, Zichao Li
Floral organs in rice (Oryza sativa) can be purple, brown, or red in color due to the accumulation of flavonoids, but the molecular mechanism underlying specific organ pigmentation is not clear. Here, we propose a C-S-A gene model for rice hull pigmentation and characterize it through genetic, molecular, and metabolomic approaches. Furthermore, we conducted phylogenetic studies to reveal the evolution of rice color. In this gene system, C1 encodes a R2R3-MYB transcription factor and acts as a color-producing gene, and S1 encodes a bHLH protein that functions in a tissue-specific manner...
March 24, 2018: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29346059/fermented-extraction-of-citrus-unshiu-peel-inhibits-viability-and-migration-of-human-pancreatic-cancers
#16
Jungwhoi Lee, Jungsul Lee, Myungseung Kim, Jae Hoon Kim
Pancreatic cancer is one of the most dangerous cancers with high mortality rates. Despite continuous efforts, there has been limited improvement in its prognosis. In this study, we prepared fermented extract of Citrus unshiu peel (fCUP) from the by-product after juice processing and then examined the anticancer effects of fCUP on human pancreatic cancer cells. Treatment with fCUP inhibited the growth of human pancreatic cancer cells through induction of caspase-3 cleavage both in vitro and in vivo. Treatment with fCUP also blocked the migration of human pancreatic cancer cells through activation of intracellular signaling pathways such as MKK3/6 and P38...
January 2018: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29337219/citrus-bioflavonoid-hesperetin-as-inhibitor-of-two-thrombin-like-snake-venom-serine-proteases-isolated-from-crotalus-simus
#17
Roney Vander Dos Santos, Fabian Villalta-Romero, Danijela Stanisic, Luiz Borro, Goran Neshich, Ljubica Tasic
Around 5.5 million people suffer from snakebites per year, with about 400,000 cases with some type of sequelae, such as amputation, and 20,000 to 125,000 cases with the fatal end. Usually, the victim outcome depends on correct, agile and many times in situ intervention based on the proper identification of the snake venom type and its potential effects, among other factors. Therefore, knowledge on the snake venom composition and a research on inhibitors of snake venom target components might ameliorate envenoming dangerous outcome...
March 1, 2018: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29334238/chemical-constituents-from-the-flowers-of-satsuma-mandarin-and-their-free-radical-scavenging-and-%C3%AE-glucosidase-inhibitory-activities
#18
Anjana Adhikari-Devkota, Sara Mustafa Idris Elbashir, Takashi Watanabe, Hari Prasad Devkota
Flowers of Citrus plants are used as mild sedatives and for the treatment of insomnia in traditional medicines. In Japan, tea made from the flowers of Satsuma mandarin is consumed as healthy drink. Hesperidin (1), hesperetin (2), rutin (3), quercetin (4), nicotiflorin (5), eriocitrin (6), narirutin (7), phenylethyl glucoside (8) and unshuoside A (9) were isolated from the MeOH extract of fresh flowers. Structure elucidation of these compounds was performed on the basis of NMR spectroscopic data. Among them, rutin (3), quercetin (4) and eriocitrin (6) showed potent free radical scavenging activity, whereas hesperetin (2) and quercetin (4) showed potent α-glucosidase inhibitory activity...
January 15, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29224841/metal-ion-improved-complexation-countercurrent-chromatography-for-enantioseparation-of-dihydroflavone-enantiomers
#19
Chao Han, Wenli Wang, Guimin Xue, Dingqiao Xu, Tianyu Zhu, Shanshan Wang, Pei Cai, Jianguang Luo, Lingyi Kong
Cu(II) ion was selected as an additive to improve the enantioseparation efficiency of three dihydroflavone enantiomers in high-speed counter-current chromatography (HSCCC), using hydroxypropyl-β-cyclodextrin (HP-β-CyD) as the chiral selector. The influences of important parameters, including the metal ion, the concentrations of HP-β-CyD and the Cu(II) ion, and the sample size were investigated. Under optimal conditions, three dihydroflavone enantiomers, including (±)-hesperetin, (±)-naringenin, and (±)-farrerol, were successfully enantioseparated...
January 12, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29211032/bioavailability-of-bergamot-citrus-bergamia-flavanones-and-biological-activity-of-their-circulating-metabolites-in-human-pro-angiogenic-cells
#20
Valentina Spigoni, Pedro Mena, Federica Fantuzzi, Michele Tassotti, Furio Brighenti, Riccardo C Bonadonna, Daniele Del Rio, Alessandra Dei Cas
Myeloid angiogenic cells (MACs) play a key role in endothelial repairing processes and functionality but their activity may be impaired by the lipotoxic effects of some molecules like stearic acid (SA). Among the dietary components potentially able to modulate endothelial function in vivo, (poly)phenolic compounds represent serious candidates. Here, we apply a comprehensive multidisciplinary approach to shed light on the prospects of Bergamot ( Citrus bergamia ), a citrus fruit rich in flavanones and other phenolic compounds, in the framework of lipotoxicity-induced MACs impairment...
December 6, 2017: Nutrients
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