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https://www.readbyqxmd.com/read/28065188/flavanone-rich-citrus-beverages-counteract-the-transient-decline-in-postprandial-endothelial-function-in-humans-a-randomised-controlled-double-masked-cross-over-intervention-study
#1
Catarina Rendeiro, Honglin Dong, Caroline Saunders, Laura Harkness, Melvin Blaze, Yanpeng Hou, Ronald L Belanger, Giulia Corona, Julie A Lovegrove, Jeremy P E Spencer
Specific flavonoid-rich foods/beverages are reported to exert positive effects on vascular function; however, data relating to effects in the postprandial state are limited. The present study investigated the postprandial, time-dependent (0-7 h) impact of citrus flavanone intake on vascular function. An acute, randomised, controlled, double-masked, cross-over intervention study was conducted by including middle-aged healthy men (30-65 years, n 28) to assess the impact of flavanone intake (orange juice: 128·9 mg; flavanone-rich orange juice: 272·1 mg; homogenised whole orange: 452·8 mg; isoenergetic control: 0 mg flavanones) on postprandial (double meal delivering a total of 81 g of fat) endothelial function...
January 9, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28063664/hesperetin-etoposide-combinations-induce-cytotoxicity-in-u2os-cells-implications-on-therapeutic-developments-for-osteosarcoma
#2
Laura Coutinho, Helena Oliveira, Ana Rita Pacheco, Luis Almeida, Francisco Pimentel, Conceição Santos, José Miguel P Ferreira de Oliveira
Osteosarcoma chemotherapy has improved survival rates, however, chemoresistance and drug toxicity still limit therapy. Drug combinations may overcome these limitations by allowing fewer chemoresistant cells to survive. The aim of this study was to evaluate the cytotoxic potential of hesperetin to osteosarcoma and to analyze the cell cycle effects of combinations of hesperetin with chemotherapeutic agents. For this, the U2OS human osteosarcoma cell line was exposed to hesperetin or hesperetin combined with etoposide or doxorubicin in defined proportions...
December 28, 2016: DNA Repair
https://www.readbyqxmd.com/read/28025998/in-vitro-screening-of-radioprotective-properties-in-the-novel-glucosylated-flavonoids
#3
Hao Yu, Jeremy S Haskins, Cathy Su, Allison Allum, Alexis H Haskins, Victoria A Salinas, Shigeaki Sunada, Taisuke Inoue, Yasushi Aizawa, Mitsuru Uesaka, Takamitsu A Kato
Novel glucosyl flavonoids are developed by the addition of glucose to naturally occurring flavonoids. Flavonoids are known antioxidants that possess radioprotective properties. In order to investigate the radioprotective properties of novel glucosyl flavonoids, in vitro DNA double-strand breaks (DSBs) analysis was carried out. In the present study, Quercetin, Naringenin, and Hesperetin groups of flavonoids included in the natural and novel glucosyl 13 flavonoids were investigated. Flavonoids were mixed with Lambda DNA, and subsequently exposed to gamma‑rays...
November 2016: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/27988309/naringenin-suppresses-edwardsiella-tarda-infection-in-gaks-cells-by-nana-sialidase-inhibition
#4
Sayaka Shinyoshi, Yuko Kamada, Koki Matsusaki, Petros Kingstone Chigwechokha, Supawan Tepparin, Kyosuke Araki, Masaharu Komatsu, Kazuhiro Shiozaki
Edwardsiella tarda (E. tarda) is a gram-negative bacterium, which causes Edwardsiellosis in aquaculture. Previous studies indicate that E. tarda NanA sialidase plays crucial roles in infection through the desialylation of glycoproteins in fish cells. On the other hand, 2-deoxy-2,3-dehydro-N-acetylneuraminic acid, classic sialidase inhibitor, negatively regulates E. tarda infection of goldfish scale GAKS cells. Here, to development the suppression model of E. tarda infection for aquaculture application, the possibility of NanA inhibitory activities in citrus phytochemicals was evaluated as citrus extracts have widely been used as a supplement in fish diets for the improvement of meat quality...
December 14, 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27987794/bioflavonoid-hesperetin-overcome-bicalutamide-induced-toxicity-by-co-delivery-in-novel-snedds-formulations-optimization-in-vivo-evaluation-and-uptake-mechanism
#5
Abhishek Arya, Hafsa Ahmad, Sachin Tulsankar, Satish Agrawal, Naresh Mittapelly, Rajkumar Boda, Rabi S Bhatta, Kalyan Mitra, Anil K Dwivedi
In the present study, we designed Bicalutamide (BCT) and Hesperetin (HSP) co-loaded self nano-emulsifying drug delivery system (SNEDDS) to encounter the problem of BCT induced toxicity, low solubility, and bioavailability. Optimized BCT-HSP SNEDDS would produce an emulsion of globule size 30.84±1.24nm with a high encapsulation efficiency of BCT (91.29%) and HSP (88.19%), and showed rapid drug release. DPPH assay confirmed the retention of antioxidant potential of HSP in SNEDDS. DCFH-DA confirmed intense green fluorescence in HSP treated groups due to the generation of reactive oxygen species...
February 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27904048/inhibitory-effect-of-hesperetin-and-naringenin-on-human-udp-glucuronosyltransferase-enzymes-implications-for-herb-drug-interactions
#6
Dan Liu, Jie Wu, Hongbo Xie, Mingyi Liu, Isaiah Takau, Hong Zhang, Yuqing Xiong, Chunhua Xia
Hesperetin (HET) and naringenin (NGR) are flavanones found in citrus (oranges and grapefruit) and Aurantii Fructus Immaturus. The present study aims to investigate the inhibition potential of HET and NGR derivatives towards one of the most important phase II drug-metabolizing enzymes-uridine diphosphate (UDP)-glucuronosyltransferases (UGTs). We used trifluoperazine as a probe substrate to test UGT1A4 activity, and recombinant UGT-catalyzed 4-methylumbelliferone glucuronidation was used as a probe reaction for other UGT isoforms...
2016: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27812412/in-silico-study-on-anti-chikungunya-virus-activity-of-hesperetin
#7
Adrian Oo, Pouya Hassandarvish, Sek Peng Chin, Vannajan Sanghiran Lee, Sazaly Abu Bakar, Keivan Zandi
BACKGROUND: The re-emerging, Aedes spp. transmitted Chikungunya virus (CHIKV) has recently caused large outbreaks in a wide geographical distribution of the world including countries in Europe and America. Though fatalities associated with this self-remitting disease were rarely reported, quality of patients' lives have been severely diminished by polyarthralgia recurrence. Neither effective antiviral treatment nor vaccines are available for CHIKV. Our previous in vitro screening showed that hesperetin, a bioflavonoid exhibits inhibitory effect on the virus intracellular replication...
2016: PeerJ
https://www.readbyqxmd.com/read/27803291/neuroprotective-efficacy-of-hesperetin-against-cadmium-induced-oxidative-stress-in-the-brain-of-rats
#8
Kalist Shagirtha, Nazima Bashir, Selvaraj MiltonPrabu
The present study was designed to investigate the neuroprotective effect of hesperetin (Hp) against cadmium (Cd)-induced neurotoxicity in rats. Cadmium (3 mg/kg body weight (b.w.), subcutaneous) administration for 3 weeks demonstrated neurotoxicity in rats by the decreased activity of acetylcholinesterase in the brain. The oxidative stress markers (thiobarbituric acid reactive substances and protein carbonyls) were significantly increased with decreased enzymatic (superoxide dismutase, catalase, glutathione peroxidase, glutathione S-transferase) and non-enzymatic antioxidants (reduced glutathione, total sulphydryl groups and vitamin C)...
November 1, 2016: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/27771138/hesperidin-interaction-to-collagen-detected-by-physico-chemical-techniques
#9
Noriko Hiraishi, Takahiro Maruno, Naoya Tochio, Ryohei Sono, Masayuki Otsuki, Tsutomu Takatsuka, Junji Tagami, Yuji Kobayashi
OBJECTIVE: Dentin collagen can be modified by some plant-derived flavonoids to improve properties of dentin organic matrix. Hesperidin (HPN), a hesperetin-7-O-rutinoside flavonoid, has a potential of dentin modification for being based on evidence that a treatment with HPN may resist collagenase degradation and arrest demineralization of human dentin. In this study, biophysical and molecular-level information on the interaction of HPN and collagen was investigated. METHODS: HPN is extracted from citrus fruits...
October 19, 2016: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/27722779/catabolism-of-citrus-flavanones-by-the-probiotics-bifidobacterium-longum-and-lactobacillus-rhamnosus
#10
Gema Pereira-Caro, Begoña Fernández-Quirós, Iziar A Ludwig, Inmaculada Pradas, Alan Crozier, José Manuel Moreno-Rojas
PURPOSE: Orange juice (OJ) flavanones undergo limited absorption in the upper gastrointestinal tract and reach the colon where they are transformed by the microbiota prior to absorption. This study investigated the ability of two probiotic bacteria, Bifidobacterium longum R0175 and Lactobacillus rhamnosus subsp. Rhamnosus NCTC 10302 to catabolise OJ flavanones. METHODS: The bacteria were incubated with hesperetin-7-O-rutinoside, naringenin-7-O-rutinoside, hesperetin and naringenin, and the culture medium and intracellular cell extracts were collected at intervals over a 48 h of incubation period...
October 8, 2016: European Journal of Nutrition
https://www.readbyqxmd.com/read/27720920/antispasmodic-effect-of-selected-citrus-flavonoids-on-rat-isolated-jejunum-specimens
#11
Marta Mendel, Magdalena Chłopecka, Natalia Dziekan, Wojciech Karlik
Citrus flavonoids are acknowledged for numerous pharmacological activities, including the myorelaxant effect on various smooth muscles. However, there is no data on their effect on jejunum contractility. Therefore, the aim of the study at hand was to evaluate the impact of hesperetin and diosmetin along with their glycosides on the motoric activity of intestine and to verify the possible mechanism of hesperetin-induced effect. The experiments were performed on rat isolated jejunum strips and were conducted under isometric conditions...
November 15, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27714757/the-protective-effect-of-the-natural-compound-hesperetin-against-fulminant-hepatitis-in-vivo-and-in-vitro
#12
Xueting Bai, Peixuan Yang, Qiaoling Zhou, Bozhi Cai, Manon Buist-Homan, He Cheng, Jiyang Jiang, Daifei Shen, Lijun Li, Xiajiong Luo, Klaas Nico Faber, Han Moshage, Ganggang Shi
BACKGROUND AND PURPOSE: Liver diseases are mostly accompanied by inflammation and hepatocyte death. Therapeutic approaches targeting both hepatocyte injury and inflammation are not available. Natural compounds are considered as potential treatment for inflammatory liver diseases. Hesperetin, a flavonoid component of citrus fruits, has been reported to have anti-inflammatory properties. The aim of this study was to evaluate the cytoprotective and anti-inflammatory properties of hesperetin both in vitro and in models of fulminant hepatitis...
January 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/27694909/inhibitory-effects-of-hesperetin-on-nav1-5-channels-stably-expressed-in-hek-293-cells-and-on-the-voltage-gated-cardiac-sodium-current-in-human-atrial-myocytes
#13
Huan Wang, Hong-Fei Wang, Hao Zhang, Chen Wang, Yu-Fang Chen, Rong Ma, Ji-Zhou Xiang, Xin-Ling Du, Qiang Tang
AIM: Voltage-gated sodium channels composed of a pore-forming α subunit and auxiliary β subunits are responsible for the upstroke of the action potential in cardiac myocytes. The pore-forming subunit of the cardiac sodium channel Nav1.5, which is encoded by SCN5A, is the main ion channel that conducts the voltage-gated cardiac sodium current (INa) in cardiac cells. The current study sought to investigate the inhibitory effects of hesperetin on human cardiac Nav1.5 channels stably expressed in human embryonic kidney 293 (HEK 293) cells and on the voltage-gated cardiac sodium current (INa) in human atrial myocytes...
December 2016: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/27665317/copper-ii-and-zinc-ii-complexes-with-flavanone-derivatives-identification-of-potential-cholinesterase-inhibitors-by-on-flow-assays
#14
André Lucio Franceschini Sarria, Adriana Ferreira Lopes Vilela, Bárbara Mammana Frugeri, João Batista Fernandes, Rose Maria Carlos, Maria Fátima das Graças Fernandes da Silva, Quezia Bezerra Cass, Carmen Lúcia Cardoso
Metal chelates strongly influence the nature and magnitude of pharmacological activities in flavonoids. In recent years, studies have shown that a promising class of flavanone-metal ion complexes can act as selective cholinesterase inhibitors (ChEIs), which has led our group to synthesize a new series of flavanone derivatives (hesperidin, hesperetin, naringin, and naringenin) complexed to either copper (II) or zinc (II) and to evaluate their potential use as selective ChEIs. Most of the synthesized complexes exhibited greater inhibitory activity against acetylcholinesterase (AChE) than against butyrylcholinesterase (BChE)...
November 2016: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/27587005/citrus-flavanones-naringenin-and-hesperetin-improve-antioxidant-status-and-membrane-lipid-compositions-in-the-liver-of-old-aged-wistar-rats
#15
Marko Miler, Jasmina Živanović, Vladimir Ajdžanović, Zorana Oreščanin-Dušić, Dragan Milenković, Aleksandra Konić-Ristić, Duško Blagojević, Verica Milošević, Branka Šošić-Jurjević
This study aimed to investigate effects of citrus flavanones naringenin (NAR) and hesperetin (HES) on liver antioxidant status and membrane phospholipid composition in 24-month-old rats. NAR and HES (15mg/kg) were administrated orally to male Wistar rats, once per day, for 4weeks. Control group received either vehicle (sunflower oil) or remained intact. The results showed decreased (p<0.05) activity of antioxidant enzymes (AOE), specifically catalase (CAT), superoxide dismutase (SOD) 1 and glutathione reductase (GR) in the liver of intact control old-aged rats in comparison to young intact controls...
November 2016: Experimental Gerontology
https://www.readbyqxmd.com/read/27535101/intestinal-transport-of-hdnd-7-a-novel-hesperetin-derivative-in-in-vitro-mdck-cell-and-in-situ-single-pass-intestinal-perfusion-models
#16
Ruonan Chen, Lan Li, Chenlin Shen, Cheng Huang, Taotao Ma, Xiaoming Meng, Zhengyue Qian, Yangyang Li, Jun Li
1. Hesperetin (HDND) possesses extensive bioactivities, however, its poor solubility and low bioavailability limit its application. HDND-7, a derivative of HDND, has better solubility and high bioavailability. In this study, we investigated the intestinal absorption mechanisms of HDND-7. 2. MDCK cells were used to examine the transport mechanisms of HDND-7 in vitro, and a rat in situ intestinal perfusion model was used to characterize the absorption of HDND-7. The concentration of HDND-7 was determined by HPLC...
August 18, 2016: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/27495155/hydroxylation-of-diverse-flavonoids-by-cyp450-bm3-variants-biosynthesis-of-eriodictyol-from-naringenin-in-whole-cells-and-its-biological-activities
#17
Luan Luong Chu, Ramesh Prasad Pandey, Narae Jung, Hye Jin Jung, Eun-Hee Kim, Jae Kyung Sohng
BACKGROUND: Cytochrome P450 monooxygenase constitutes a significant group of oxidative enzymes that can introduce an oxygen atom in a high regio- and stereo-selectivity mode. We used the Bacillus megaterium cytochrome P450 BM3 (CYP450 BM3) and its variants namely mutant 13 (M13) and mutant 15 (M15) for the hydroxylation of diverse class of flavonoids. RESULTS: Among 20 flavonoids, maximum seven flavonoids were hydroxylated by the variants while none of these molecules were accepted by CYP450 BM3 in in vitro reaction...
August 5, 2016: Microbial Cell Factories
https://www.readbyqxmd.com/read/27489195/potentiation-of-luteolin-cytotoxicity-by-flavonols-fisetin-and-quercetin-in-human-chronic-lymphocytic-leukemia-cell-lines
#18
Katrin Sak, Kristi Kasemaa, Hele Everaus
Despite numerous studies chronic lymphocytic leukemia (CLL) still remains an incurable disease. Therefore, all new compounds and novel strategies which are able to eradicate CLL cells should be considered as valuable clues for a potential future remedy against this malignancy. In the present study, the cytotoxic profiles of natural flavonoids were described in two human CLL cell lines, HG-3 and EHEB, indicating the flavone luteolin as the most potent flavonoid with half-maximal inhibitory constants (IC50) of 37 μM and 26 μM, respectively...
September 14, 2016: Food & Function
https://www.readbyqxmd.com/read/27488098/urinary-excretion-of-citrus-flavanones-and-their-major-catabolites-after-consumption-of-fresh-oranges-and-pasteurized-orange-juice-a-randomized-cross-over-study
#19
Julian K Aschoff, Ken M Riedl, Jessica L Cooperstone, Josef Högel, Anja Bosy-Westphal, Steven J Schwartz, Reinhold Carle, Ralf M Schweiggert
SCOPE: Orange juice contains flavanones including hesperidin and narirutin, albeit at lower concentrations as compared to orange fruit. Therefore, we compared bioavailability and colonic catabolism of flavanones from orange juice to a 2.4-fold higher dose from fresh oranges. METHODS AND RESULTS: Following a randomized two-way cross-over design, 12 healthy subjects consumed a test meal comprising either fresh oranges or pasteurized orange juice, delivering 1774 and 751 μmol of total Citrus flavanones, respectively...
December 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27474296/development-and-validation-of-a-rp-uhplc-esi-ms-ms-method-for-the-chiral-separation-and-determination-of-flavanone-naringenin-and-hesperetin-enantiomers
#20
Irena Baranowska, Judyta Hejniak, Sylwia Magiera
A quick and sensitive RP-UHPLC-ESI-MS/MS method for the separation of flavanone, naringenin and hesperetin enantiomers was developed. The separation of analytes was performed using a Chiralpak AD-3R column, and methanol was used as the mobile phase. Detection was carried out using a triple quadrupole tandem mass spectrometer with an electrospray ionisation source. Positive ionisation and multiple reaction monitoring (MRM) were used. The developed method showed satisfactory linearity with determination coefficients greater than 0...
October 1, 2016: Talanta
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