keyword
MENU ▼
Read by QxMD icon Read
search

hesperetin

keyword
https://www.readbyqxmd.com/read/28923363/anti-inflammatory-effects-of-flavonoids-in-neurodegenerative-disorders
#1
Carmela Spagnuolo, Stefania Moccia, Gian Luigi Russo
Neuroinflammation is one of the main mechanisms involved in the progression of several neurodegenerative diseases, such as Parkinson, Alzheimer, multiple sclerosis, amyotrophic lateral sclerosis and others. The activation of microglia is the main feature of neuroinflammation, promoting the release of pro-inflammatory cytokines and resulting in the progressive neuronal cell death. Natural compounds, such as flavonoids, possess neuroprotective potential probably related to their ability to modulate the inflammatory responses involved in neurodegenerative diseases...
September 7, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28883473/identification-of-aspergillus-fumigatus-udp-galactopyranose-mutase-inhibitors
#2
Julia S Martin Del Campo, Meital Eckshtain-Levi, Nancy J Vogelaar, Pablo Sobrado
Aspergillus fumigatus is an opportunistic human pathogen responsible for deadly, invasive infections in immunocompromised patients. The A. fumigatus cell wall is a complex network of polysaccharides among them galactofuran, which is absent in humans. UDP-galactopyranose mutase (UGM) catalyzes the conversion of UDP-galactofuranose (UDP-Galf) to UDP-galactopyranose (UDP-Galp) and is an important virulence factor. UGM is a flavin-dependent enzyme that requires the reduced flavin for activity; flavin reduction is achieved by reaction with NADPH...
September 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28839359/mechanism-of-fructus-aurantii-flavonoids-promoting-gastrointestinal-motility-from-organic-and-inorganic-endogenous-substances-combination-point-of-view
#3
Shuai Wang, Yong-Rui Bao, Tian-Jiao Li, Ting Yu, Xin Chang, Guan-Lin Yang, Xian-Sheng Meng
BACKGROUND: Fructus Aurantii (FA) derived from the dried, and unripe fruit of Citrus aurantium L. is one of the commonly used traditional Chinese medicines to treat gastrointestinal motility dysfunction diseases. According to the literature research, FA flavonoids (FAF) are important active ingredients of FA promoting gastrointestinal motility, but the exact material basis and mechanism of action are still not very clear. OBJECTIVE: This experiment was designed to illustrate the material basis of FAF promoting gastrointestinal motility and explore the mechanism of action from an organic and inorganic combination point of view...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28820428/pharmacokinetic-analysis-of-an-oral-multicomponent-joint-dietary-supplement-phycox-%C3%A2-in-dogs
#4
Stephanie E Martinez, Ryan Lillico, Ted M Lakowski, Steven A Martinez, Neal M Davies
Despite the lack of safety, efficacy and pharmacokinetic (PK) studies, multicomponent dietary supplements (nutraceuticals) have become increasingly popular as primary or adjunct therapies for clinical osteoarthritis in veterinary medicine. Phycox(®) is a line of multicomponent joint support supplements marketed for joint health in dogs and horses. Many of the active constituents are recognized anti-inflammatory and antioxidant agents. Due to a lack of PK studies in the literature for the product, a pilot PK study of select constituents in Phycox(®) was performed in healthy dogs...
August 18, 2017: Pharmaceutics
https://www.readbyqxmd.com/read/28774689/design-synthesis-and-biological-evaluation-of-hesperetin-derivatives-as-potent-anti-inflammatory-agent
#5
Hai-Wen Ding, Ai-Ling Huang, Yi-Long Zhang, Bo Li, Chen Huang, Tao-Tao Ma, Xiao-Ming Meng, Jun Li
A flavonoid hesperetin is reported to have a variety of biological activities, including anticancer, antiviral, antioxidant, neuroprotective and anti-inflammatory properties. Thirty-one novel hesperetin derivatives were designed, synthesized and evaluated for anti-inflammatory activity using RAW264.7 cells and CCl4-induced acute liver injury model. Among these compounds, 5b displayed the excellent anti-inflammatory activity on decreasing NO, IL-6 and TNF-α both in vitro and vivo. In addition, 5b could also reduce the release of NO, IL-6 and TNF-α production by LPS stimulated RAW 264...
August 1, 2017: Fitoterapia
https://www.readbyqxmd.com/read/28753501/the-effect-of-active-components-from-citrus-fruits-on-dentin-mmps
#6
Zhengya Liu, Fang Li, Ling Zhang, Haohan Yu, Fan Yu, Jihua Chen
OBJECTIVES: This study was aimed to evaluate the anti-matrix metalloproteinases (MMPs) ability of active components from citrus fruits (hesperetin: Hst, hesperidin: Hsd and naringenin: Nge). METHODS: Inactivation effects of citrus flavonoids (Hst, Hsd, Nge) at different concentrations on soluble collagenase were measured using a fluorometric assay. Matrix-bound endogenous MMPs activity was evaluated via dry mass loss and hydroxyproline (HYP) release of demineralized human dentin...
July 20, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28747329/bioavailability-of-orange-juice-poly-phenols-the-impact-of-short-term-cessation-of-training-by-male-endurance-athletes
#7
Gema Pereira-Caro, Thelma Polyviou, Iziar A Ludwig, Ana-Maria Nastase, José Manuel Moreno-Rojas, Ada L Garcia, Dalia Malkova, Alan Crozier
Background: Physical exercise has been reported to increase the bioavailability of citrus flavanones.Objective: We investigated the bioavailability of orange juice (OJ) (poly)phenols in endurance-trained males before and after cessation of training for 7 d.Design: Ten fit, endurance-trained males, with a mean ± SD maximal oxygen consumption of 58.2 ± 5.3 mL · kg(-1) · min(-1), followed a low (poly)phenol diet for 2 d before drinking 500 mL of OJ containing 398 μmol of (poly)phenols, of which 330 μmol was flavanones...
September 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28711784/urinary-metabolite-profiling-of-flavonoids-in-chinese-volunteers-after-consumption-of-orange-juice-by-uflc-q-tof-ms-ms
#8
Xuan Zeng, Weiwei Su, Yang Bai, Taobin Chen, Zenghao Yan, Jiawei Wang, Minmin Su, Yuying Zheng, Wei Peng, Hongliang Yao
The metabolism of flavonoids derived from orange juice in Chinese volunteers has not been well investigated. With the ultra-fast liquid chromatography-quadrupole-time-of-flight tandem mass spectrometry (UFLC-Q-TOF-MS/MS) system, orange juice-derived flavonoids, as well as metabolites contained in urine collected from healthy Chinese volunteers after consumption of 250mL orange juice, were systematically identified and quantified. Finally, a total of 9 flavonoids and 30 metabolites were detected. Obtained results revealed that flavonoids derived from orange juice underwent extensive phase II metabolism in human, mainly comprising glucuronidation and sulfation...
September 1, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28690190/immunomodulatory-potential-of-hesperetin-and-chrysin-through-the-cellular-and-humoral-response
#9
Aïcha Sassi, Imen Mokdad Bzéouich, Nadia Mustapha, Mouna Maatouk, Kamel Ghedira, Leila Chekir-Ghedira
Flavonoids are polyphenols frequently consumed in the diet they have been suggested to exert a number of beneficial actions on human health, including anti-inflammatory activity. This study investigated the immunomodulatory effects of two flavonoids, Chrysin and Hesperetin. The effects of flavonoids on B and T cell proliferation were assessed on splenocytes stimulated or not with mitogens. However, their effects on cytotoxic T lymphocyte (CTL) and natural killer (NK) activities were assessed in splenocytes co-incubated with target cells...
July 6, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28672874/design-synthesis-and-evaluation-of-hesperetin-derivatives-as-potential-multifunctional-anti-alzheimer-agents
#10
Bo Li, Ai-Ling Huang, Yi-Long Zhang, Zeng Li, Hai-Wen Ding, Cheng Huang, Xiao-Ming Meng, Jun Li
In this study we designed and synthesized a series of new hesperetin derivatives on the basis of the structural characteristics of acetylcholinesterase (AChE) dual-site inhibitors. The activity of the novel derivatives was also evaluated. Results showed that the synthesized hesperetin derivatives displayed stronger inhibitory activity against AChE and higher selectivity than butyrylcholine esterase (BuChE) (selectivity index values from 68 to 305). The Lineweaver-Burk plot and molecular docking study showed that these compounds targeted both the peripheral anionic site (PAS) and catalytic active site (CAS) of AChE...
June 26, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28641484/protective-effect-of-hesperetin-against-haloperidol-induced-orofacial-dyskinesia-and-catalepsy-in-rats
#11
Dinesh Dhingra, Shikha Goswami, Nidhi Gahalain
OBJECTIVES: The present study was designed to evaluate the effect of hesperetin on haloperidol-induced orofacial dyskinesia and catalepsy in Wistar male albino rats. METHODS: Haloperidol (1 mg/kg, ip) was administered for 21 successive days to induce orofacial dyskinesia and catalepsy. Hesperetin (50 and 100 mg/kg, po) was administered 10 min prior to the injection of haloperidol for 21 successive days. Vacuous chewing movements (VCMs), tongue protrusions, catalepsy, and locomotor activity scores were recorded on 7th, 14th, and 22nd day of drug treatment...
June 22, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/28622602/assessment-of-the-phenolic-profile-antimicrobial-activity-and-oxidative-stability-of-transgenic-perilla-frutescens-l-overexpressing-tocopherol-methyltransferase-%C3%AE-tmt-gene
#12
Bimal Kumar Ghimire, Chang Yeon Yu, Ill-Min Chung
This study evaluated the effects of enhanced concentrations of α-tocopherol and phenolic compounds on the resistance and stability of Perilla oil in transgenic Perilla frutescens plants against various tested pathogenic bacteria by over-expressing the γ-tmt gene. The concentration of phenolic compounds in the non-transgenic samples was 9313.198 ± 18.887 μg g(-1) dry weight (DW), whereas the total concentration of the transgenic samples ranged from 9118.015 ± 18.822 to 10527.612 ± 20.411 μg g(-1) DW...
June 7, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28615861/in-vitro-ovicidal-activity-of-peganum-harmala-seeds-extract-on-the-eggs-of-fasciola-hepatica
#13
Mohammad Moazeni, Zahra Sadat Saadaty Ardakani, Mohammad Jamal Saharkhiz, Jafar Jalaei, Ali Asghar Khademolhoseini, Shahab Shams Esfand Abad, Amir Mootabi Alavi
Peganum harmala seeds extract has been previously reported to have antimicrobial and other medicinal properties. The aim of this study was to evaluate the ovicidal activity of the methanolic extract of P. harmala seeds against the eggs of F. hepatica. The phenolic compounds of the methanolic extract of P. harmala seeds were identified by HPLC analysis. Catechin, rutin, p-Coumaric acid, chloregenic acid and hesperetin were found to be the major phenolic compounds. F. hepatica eggs were collected from the gall bladder of naturally infected sheep...
June 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/28573351/mitigating-potential-of-melissa-officinale-against-as-3-induced-cytotoxicity-and-transcriptional-alterations-of-hsp70-and-hsp27-in-fish-channa-punctatus-bloch
#14
Shraddha Dwivedi, Manoj Kumar, Sunil P Trivedi
The mitigating potential of Melissa officinale (MO) (Lamiaceae) against arsenite (As(3+))-induced oxidative stress, cytogenotoxicity, and expression of stress genes in fish, Channa punctatus (Bloch), teleost, was explored. After confirming the composition of MO extract, caffeic acid (0.96%), hesperidin (1.73%), naringenin (7.70%), lutenolin (3.29%), kaempferol (11.46%) and hesperetin (6.24%), by HPLC-PDA analysis, the experiment was set up in six groups (G1-G6), each containing 10 specimens. Blood, muscle, gills and liver tissues of control and treated fishes were excised at an interval of 24 till 96 h...
July 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28558784/hesperetin-5-7-3-o-triacetate-suppresses-airway-hyperresponsiveness-in-ovalbumin-sensitized-and-challenged-mice-without-reversing-xylazine-ketamine-induced-anesthesia-in-normal-mice
#15
You-Lan Yang, Chi-Li Chen, Chi-Ming Chen, Wun-Chang Ko
BACKGROUND: We recently reported that hesperetin-5,7,3'-O-triacetate (HTA) dually inhibited phosphodiesterase (PDE)3/4 with a therapeutic ratio of 20.8. The application and development of PDE4 inhibitors for treating asthma or COPD are limited by their side effects, such as nausea, vomiting and gastric hypersecretion. PDE4 inhibitors were reported to reverse xylazine/ketamine-induced anesthesia in rats and triggered vomiting in ferrets. Thus the reversing effect of HTA on xylazine/ketamine-induced anesthesia in mice was studied to assess emetic effect of HTA...
May 30, 2017: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28539744/biological-effects-of-hesperetin-on-interleukin-6-phosphorylated-signal-transducer-and-activator-of-transcription-3-pathway-signaling-in-prostate-cancer-pc3-cells
#16
Moein Shirzad, Esfandiar Heidarian, Pezhman Beshkar, Mostafa Gholami-Arjenaki
BACKGROUND: Interleukin-6 (IL-6) is a multifunctional glycoprotein that regulates the growth of some tumors, including prostate carcinomas due to signal transducer and activator of transcription 3 (STAT3), extracellular signal-regulated kinases 1/2 (ERK1/2), and AKT signaling pathways. Hesperetin, as a flavanone, has several biological properties such as antitumor and anti-inflammatory. OBJECTIVE: This study was carried out to evaluate the biological effects of hesperetin on the IL-6 gene expression and phosphorylated STAT3, AKT, and ERK1/2 signaling pathways in PC3 prostate cancer (PC) cells...
April 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28537448/hesperetin-induces-an-apoptosis-triggered-extrinsic-pathway-and-a-p53-independent-pathway-in-human-lung-cancer-h522-cells
#17
Ramesh Elango, Jegan Athinarayanan, Vaiyapuri Periasamy Subbarayan, David K Y Lei, Ali A Alshatwi
We studied the chemoprevention property of hesperetin on H522 cells using MTT, an apoptosis assay, an analysis of cell cycle progression, and the mitochondrial membrane potential, and apoptotic marker gene expression was determined using quantitative PCR. Hesperetin enhanced apoptotic cell death and mitochondrial membrane potential loss in H522 cells. Hesperetin up-regulated the levels of Fas, FADD, and caspase-8 expression and downregulted the levels of caspase-3 and caspase-9, p53, and Bax expression in H522 cells...
May 24, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28531921/hesperetin-post-treatment-prevents-rat-cardiomyocytes-from-hypoxia-reoxygenation-injury-in-vitro-via-activating-pi3k-akt-signaling-pathway
#18
Shangfei He, Xianbao Wang, Yongkang Zhong, Lu Tang, Ya Zhang, Yuanna Ling, Zhipeng Tan, Pingzhen Yang, Aihua Chen
Hesperidin (HES), a citrus fruit extract, has beneficial effects on various ischemia/reperfusion (I/R) models. Here, we investigated the possible positive effect of hesperetin (HPT), an active metabolite of HES, and identified the potential molecular mechanisms involved in cardiomyocytes H/R-induced injury. To construct the cardiomyocyte model of hypoxia/reoxygenation (H/R) injury, cultured neonatal rat cardiomyocytes were subjected to 3h of hypoxia followed by 3h of reoxygenation. Cell viability and apoptosis were detected...
July 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28509871/nutraceutical-value-of-citrus-flavanones-and-their-implications-in-cardiovascular-disease
#19
REVIEW
Lara Testai, Vincenzo Calderone
Background- Cardiovascular diseases, including myocardial infarction, dyslipidaemia and coronary artery pathology, are a major cause of illness and death in Western countries. Therefore, identifying effective therapeutic approaches and their cellular signalling pathways is a challenging goal for medicine. In this regard, several epidemiological studies demonstrate a relationship between the intake of flavonoid-rich foods and the reduction of cardiovascular risk factors and mortality. In particular, flavonoids present in citrus fruits, such as oranges, bergamots, lemons and grapefruit (95% from flavanones), are emerging for their considerable nutraceutical value...
May 16, 2017: Nutrients
https://www.readbyqxmd.com/read/28504280/metabolic-profile-and-underlying-improved-bio-activity-of-fructus-aurantii-immaturus-by-human-intestinal-bacteria
#20
Xing Yan Liu, Meng Lin Fan, Huai You Wang, Bo Yang Yu, Ji Hua Liu
Fructus aurantii immaturus (FAI) is the dried young fruit of Citrus aurantium L. or Citrus sinensis L. Osbeck. The purpose of this paper was to investigate the metabolic fate of FAI upon incubation with human intestinal bacteria, meanwhile to evaluate the antioxidant and anti-inflammatory activities of FAI and the transformed Fructus aurantii immaturus (TFAI). The water extract of FAI was anaerobically incubated with human intestinal bacterial suspensions for 48 h at 37 °C. Liquid chromatography-hybridised with quadrupole-time-of-flight mass spectrometry (LC-Q-TOF/MS) was applied to identify FAI metabolites...
June 21, 2017: Food & Function
keyword
keyword
104018
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"