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https://www.readbyqxmd.com/read/29779108/microrna-dependent-regulation-of-igf1r-gene-expression-in-hormone-sensitive-and-hormone-resistant-prostate-cancer-cells
#1
V A Tarasov, M G Tyutyakina, M A Makhotkin, E F Shin, A V Naboka, A N Mashkarina, D A Chebotarev, E N Cherkasova, M I Kogan, M B Chibichyan, D G Matishov
Using multiple parallel sequencing on Illumina platform, we identified eight microRNAs that showed significant opposite changes of gene expression in cells of the hormone-sensitive LNCaP prostate cancer cell line and in cells of the hormone-resistant DU-145 cell line, in comparison to the microRNA expression in the normal prostate tissue cells. We found that the insulin-like growth factor 1 receptor (IGF1R) gene is a target of five microRNAs whose expression is increased in LNCaP cells and reduced in DU-145 cells...
March 2018: Doklady. Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29770762/mri-us-fusion-guided-prostate-biopsy-allows-for-equivalent-cancer-detection-with-significantly-fewer-needle-cores-in-biopsy-naive-men
#2
Vidhush K Yarlagadda, Win Shun Lai, Jennifer B Gordetsky, Kristin K Porter, Jeffrey W Nix, John V Thomas, Soroush Rais-Bahrami
PURPOSE: We aimed to investigate the efficiency and cancer detection of magnetic resonance imaging (MRI) / ultrasonography (US) fusion-guided prostate biopsy in a cohort of biopsy-naive men compared with standard-of-care systematic extended sextant transrectal ultrasonography (TRUS)-guided biopsy. METHODS: From 2014 to 2016, 72 biopsy-naive men referred for initial prostate cancer evaluation who underwent MRI of the prostate were prospectively evaluated. Retrospective review was performed on 69 patients with lesions suspicious for malignancy who underwent MRI/US fusion-guided biopsy in addition to systematic extended sextant biopsy...
May 2018: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/29765912/oncolytic-adenovirus-ad657-for-systemic-virotherapy-against-prostate-cancer
#3
Tien V Nguyen, Catherine M Crosby, Gregory J Heller, Zachary I Mendel, Mary E Barry, Michael A Barry
Background: Human species C adenovirus serotype 5 (Ad5) is the archetype oncolytic adenovirus and has been used in the vast majority of preclinical and clinical tests. While Ad5 can be robust, species C Ad6 has lower seroprevalence, side effects, and appears to be more potent as a systemic therapy against a number of tumors than Ad5. Historically, there have only been four species C human adenoviruses: serotypes 1, 2, 5, and 6. More recently a new species C adenovirus, Ad57, was identified...
2018: Oncolytic Virotherapy
https://www.readbyqxmd.com/read/29765545/multi-institution-analysis-of-racial-disparity-among-african-american-men-eligible-for-prostate-cancer-active-surveillance
#4
Michael Dinizo, Weichung Shih, Young Suk Kwon, Daniel Eun, Adam Reese, Laura Giusto, Edouard J Trabulsi, Bertram Yuh, Nora Ruel, Daniel Marchalik, Jonathan Hwang, Shilajit D Kundu, Scott Eggener, Isaac Yi Kim
There is a significant controversy on whether race should be a factor in considering active surveillance for low-risk prostate cancer. To address this question, we analyzed a multi-institution database to assess racial disparity between African-American and White-American men with low risk prostate cancer who were eligible for active surveillance but underwent radical prostatectomy. A retrospective analysis of prospectively collected clinical, pathologic and oncologic outcomes of men with low-risk prostate cancer from seven tertiary care institutions that underwent radical prostatectomy from 2003-2014 were used to assess potential racial disparity...
April 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29761838/proliferation-and-invasion-of-colon-cancer-cells-are-suppressed-by-knockdown-of-top2a
#5
Rui Zhang, Jian Xu, Jian Zhao, Jing H Bai
Recent research has shown that TOP2A plays an important role in the tumorigenesis of many malignancies, such as breast cancer, ovarian cancer, and prostate cancer. However, few studies have been conducted on TOP2A expression and functions in colon cancer. In the present study, we found that TOP2A expression was obviously elevated in colon cancer tissues compared to adjacent non-cancerous tissues. Depletion of TOP2A in HCT116 and SW480 colon cancer cells by transfection of specific small interfering RNA significantly suppressed proliferation and inhibited invasion of cells, even induced apoptosis as indicated by both MTT assay, Annexin V/propidium iodide staining, and Transwell assay...
May 15, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29761524/the-24th-annual-prostate-cancer-foundation-scientific-retreat-report
#6
REVIEW
Andrea K Miyahira, Howard R Soule
INTRODUCTION: The 24th Annual Prostate Cancer Foundation (PCF) Scientific Retreat was held from October 5-7, 2017, at the Omni Shoreham Hotel in Washington, DC. METHODS: The PCF Scientific Retreat is a scientific conference that specifically focuses on cutting edge research deemed to have significant promise for accelerating advances in prostate cancer biology and treatment. RESULTS: Themes highlighted at this year's meeting included: (i) new understandings in prostate cancer biology and disease progression; (ii) new mechanisms and treatment targets in advanced prostate cancer; (iii) advances in precision medicine genomics, germline genetics, and selection of targeted therapies; (iv) PSMA-targeted agents for PET imaging and radionuclide therapy; (v) approaches for improving the efficacy of immunotherapy in prostate cancer; (vi) applications of 3D Genomics in prostate cancer research; and (vii) potential applications of artificial intelligence in prostate cancer...
May 15, 2018: Prostate
https://www.readbyqxmd.com/read/29760660/ophiopogonin-d-a-natural-product-from-radix-ophiopogonis-induces-in-vitro-and-in-vivo-ripk1-dependent-and-caspase-independent-apoptotic-death-in-androgen-independent-human-prostate-cancer-cells
#7
Zongliang Lu, He Wang, Mingxing Zhu, Wei Song, Jiajia Wang, Changpeng Wu, Ya Kong, Jing Guo, Na Li, Jie Liu, Yanwu Li, Hongxia Xu
Objective: The purpose of this study was to evaluate the anticancer effects of Ophiopogonin D' (OPD', a natural product extracted from a traditional Chinese medicine ( Radix Ophiopogonis ) against androgen-independent prostate cancer cells and to explore the underlying molecular mechanism(s) of action. Methods: The CCK-8 assay was used to assess the viability of prostate cancer cells. The cell morphology was examined by an ultrastructural analysis via transmission electron microscopy. Cells in apoptosis (early and late stages) were detected using an Annexin V-FITC/propidium iodide kit with a FACSCaliber flow cytometer...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29757368/the-long-noncoding-rna-landscape-of-neuroendocrine-prostate-cancer-and-its-clinical-implications
#8
Varune Rohan Ramnarine, Mohammed Alshalalfa, Fan Mo, Noushin Nabavi, Nicholas Erho, Mandeep Takhar, Robert Shukin, Sonal Brahmbhatt, Alexander Gawronski, Maxim Kobelev, Mannan Nouri, Dong Lin, Harrison Tsai, Tamara L Lotan, R Jefferey Karnes, Mark A Rubin, Amina Zoubeidi, Martin E Gleave, Cenk Sahinalp, Alexander W Wyatt, Stanislav V Volik, Himisha Beltran, Elai Davicioni, Yuzhuo Wang, Colin C Collins
Background: Treatment induced neuroendocrine prostate cancer (tNEPC) is an aggressive variant of late-stage metastatic castrate resistant (mCRPC) prostate cancer that commonly arises through neuroendocrine transdifferentiation (NEtD). Treatment options are limited, ineffective, and for most patients, results in death in less than a year. We previously developed a first-in-field patient-derived xenograft (PDX) model of NEtD. Longitudinal deep transcriptome profiling of this model enabled monitoring of dynamic transcriptional changes during NEtD and in the context of androgen deprivation...
May 10, 2018: GigaScience
https://www.readbyqxmd.com/read/29755671/should-reporting-of-peri-neural-invasion-and-extra-prostatic-extension-be-mandatory-in-prostate-cancer-biopsies-correlation-with-outcome-in-biopsy-cases-treated-conservatively
#9
Amar S Ahmad, Vishnu Parameshwaran, Luis Beltran, Gabrielle Fisher, Bernard V North, David Greenberg, Geraldine Soosay, Henrik Møller, Peter Scardino, Jack Cuzick, Daniel M Berney
The identification of perineural invasion (PNI) and extraprostatic extension (ECE) in prostate cancer (PC) biopsies is time consuming and can be difficult. Although this is required information in many datasets, there is little evidence on their effect on outcome in patients treated conservatively. Cases of PC were identified from three cancer registries in the UK from men with clinically localized prostate cancer diagnosed by needle biopsy from 1990-2003. The endpoint was prostate cancer death (DOD). Patients treated radically within 6 months, those with objective evidence of metastases or who had prior hormone therapy were excluded...
April 17, 2018: Oncotarget
https://www.readbyqxmd.com/read/29752528/impact-of-a-web-based-prostate-cancer-treatment-decision-aid-on-patient-reported-decision-process-parameters-results-from-the-prostate-cancer-patient-centered-care-trial
#10
Maarten Cuypers, Romy E D Lamers, Paul J M Kil, Lonneke V van de Poll-Franse, Marieke de Vries
PURPOSE: To compare patients' evaluation of the treatment decision-making process in localized prostate cancer between counseling that included an online decision aid (DA) and standard counseling. METHODS: Eighteen Dutch hospitals were randomized to DA counseling (n = 235) or the control group with standard counseling (n = 101) in a pragmatic, cluster randomized controlled trial. The DA was provided to patients at, or soon after diagnosis. Decisional conflict, involvement, knowledge, and satisfaction with information were assessed with a questionnaire after treatment decision-making...
May 12, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29750125/vitamin-d-status-and-its-associated-risk-factors-among-adults-in-the-southwest-region-of-cameroon
#11
Delphine A Tangoh, Tobias O Apinjoh, Yasir Mahmood, Robert V Nyingchu, Beatrice A Tangunyi, Emmanuel N Nji, Abid Azhar, Eric A Achidi
Background: Vitamin D has been shown to exert its actions on the musculoskeletal, gastrointestinal, prostate, renal, endocrine, immune, and cardiovascular systems. Current reported data of hypovitaminosis D reveals a global pandemic, with an estimated one billion people worldwide presenting with hypovitaminosis D. Objective: This study aimed at investigating the vitamin D status and its associated risk factors in Cameroonians from the South West Region. Method: The study was a community- and hospital-based prospective longitudinal study...
2018: Journal of Nutrition and Metabolism
https://www.readbyqxmd.com/read/29748961/growth-hormone-releasing-hormone-receptor-antagonists-modify-molecular-machinery-in-the-progression-of-prostate-cancer
#12
Laura Muñoz-Moreno, Andrew V Schally, Juan C Prieto, M José Carmena, Ana M Bajo
BACKGROUND: Therapeutic strategies should be designed to transform aggressive prostate cancer phenotypes to a chronic situation. To evaluate the effects of the new growth hormone-releasing hormone receptor (GHRH-R) antagonists: MIA-602, MIA-606, and MIA-690 on processes associated with cancer progression as cell proliferation, adhesion, migration, and angiogenesis. METHODS: We used three human prostate cell lines (RWPE-1, LNCaP, and PC3). We analyzed several molecules such as E-cadherin, β-catenin, Bcl2, Bax, p53, MMP2, MMP9, PCNA, and VEGF and signaling mechanisms that are involved on effects exerted by GHRH-R antagonists...
May 10, 2018: Prostate
https://www.readbyqxmd.com/read/29744932/expression-and-role-of-paics-a-de-novo-purine-biosynthetic-gene-in-prostate-cancer
#13
Balabhadrapatruni V S K Chakravarthi, Moloy T Goswami, Satya S Pathi, Matthew Dodson, Darshan S Chandrashekar, Sumit Agarwal, Saroj Nepal, Sai Akshaya Hodigere Balasubramanya, Javed Siddiqui, Robert J Lonigro, Arul M Chinnaiyan, Lakshmi P Kunju, Nallasivam Palanisamy, Sooryanarayana Varambally
No abstract text is available yet for this article.
June 2018: Prostate
https://www.readbyqxmd.com/read/29740153/an-initial-melanoma-diagnosis-may-increase-the-subsequent-risk-of-prostate-cancer-results-from-the-new-south-wales-cancer-registry
#14
D Cole-Clark, V Nair-Shalliker, A Bang, K Rasiah, V Chalasani, D P Smith
Emerging evidence suggests that a diagnosis of cutaneous melanoma (CM) may be associated with prostate cancer (PC) incidence. We examined if the incidence of CM was associated with an increased subsequent risk of PC. We used data from the New South Wales Cancer Registry for all CM and PC cases diagnosed between January 1972 and December 2008. We calculated the age standardized incidence ratio (SIR) and 95% confidence intervals (95% CI) for PC incidence following a CM diagnosis, applying age- and calendar- specific rates to the appropriate person years at risk...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29740048/matrilysin-mmp-7-cleavage-of-perlecan-hspg2-complexed-with-semaphorin-3a-supports-fak-mediated-stromal-invasion-by-prostate-cancer-cells
#15
Brian J Grindel, Jerahme R Martinez, Tristen V Tellman, Daniel A Harrington, Hamim Zafar, Luay Nakhleh, Leland W Chung, Mary C Farach-Carson
Interrupting the interplay between cancer cells and extracellular matrix (ECM) is a strategy to halt tumor progression and stromal invasion. Perlecan/heparan sulfate proteoglycan 2 (HSPG2) is an extracellular proteoglycan that orchestrates tumor angiogenesis, proliferation, differentiation and invasion. Metastatic prostate cancer (PCa) cells degrade perlecan-rich tissue borders to reach bone, including the basement membrane, vasculature, reactive stromal matrix and bone marrow. Domain IV-3, perlecan's last 7 immunoglobulin repeats, mimics native proteoglycan by promoting tumoroid formation...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29734118/multidose-formulation-of-ready-to-use-177-lu-psma-617-in-a-centralized-radiopharmacy-set-up
#16
Sudipta Chakraborty, K V Vimalnath, Rubel Chakravarty, H D Sarma, Ashutosh Dash
Lutetium-177-labeled PSMA inhibitor has emerged as a promising modality for targeted therapy of prostate carcinoma. A protocol for regular multidose formulation of ready-to-use 177 Lu-PSMA-617 has been developed based on detailed and systematic radiochemical investigations. The formulation meets the requirements of clinical use and can be shipped to nuclear medicine centres for administration up to 4 days from the date of formulation. The reported protocol would be useful toward facilitating widespread clinical utilization of 177 Lu-PSMA-617 in the management of prostate cancer...
April 26, 2018: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/29734037/pepsavi-ms-reveals-anticancer-and-antifungal-cycloviolacins-in-viola-odorata
#17
Nicole C Parsley, Christine L Kirkpatrick, Christopher M Crittenden, Javad Ghassemi Rad, David W Hoskin, Jennifer S Brodbelt, Leslie M Hicks
Widespread resistance to antimicrobial and cancer therapeutics is evolving in every country worldwide and has a direct impact on global health, agriculture and the economy. The specificity and selectivity of bioactive peptide natural products present a possible stopgap measure to address the ongoing deficit of new therapeutic compounds. PepSAVI-MS (Statistically-guided bioActive Peptides prioritized VIa Mass Spectrometry) is an adaptable method for the analysis of natural product libraries to rapidly identify bioactive peptides...
May 4, 2018: Phytochemistry
https://www.readbyqxmd.com/read/29732210/effectiveness-of-tranexamic-acid-for-decreasing-bleeding-in-prostate-surgery-a-systematic-review-and-meta-analysis
#18
REVIEW
Sergio Hernando Mina, Herney Andres Garcia-Perdomo
Introduction: The objective of this study was to determine the effectiveness of tranexamic acid in decreasing bleeding in patients undergoing prostate surgery. Material and methods: All clinical experiments were included without language restrictions. The inclusion criteria were as follows: men over 18 years of age who underwent prostate surgery (transurethral, prostate adenectomy, and radical prostatectomy) and received tranexamic acid prior to prostate surgery as a preventive measure for perioperative hemorrhage...
2018: Central European Journal of Urology
https://www.readbyqxmd.com/read/29731160/contouring-of-prostate-tumors-on-multiparametric-mri-evaluation-of-clinical-delineations-in-a-multicenter-radiotherapy-trial
#19
Marcel A van Schie, Cuong V Dinh, Petra J van Houdt, Floris J Pos, Stijn W T J P Heijmink, Linda G W Kerkmeijer, Alexis N T J Kotte, Raymond Oyen, Karin Haustermans, Uulke A van der Heide
PURPOSE: To date no guidelines are available for contouring prostate cancer inside the gland, as visible on multiparametric (mp-) MRI. We assessed inter-institutional differences in interpretation of mp-MRI in the multicenter phase III FLAME trial. METHODS: We analyzed clinical delineations on mp-MRI and clinical characteristics from 260 patients across three institutes. We performed a logistic regression analysis to examine each institute's weighting of T2w, ADC and Ktrans intensity maps in the delineation of the cancer...
May 3, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29730133/cytotoxic-effect-of-kalanchoe-flammea-and-induction-of-intrinsic-mitochondrial-apoptotic-signaling-in-prostate-cancer-cells
#20
Iván Arias-González, Alejandro M García-Carrancá, Jorge Cornejo-Garrido, Cynthia Ordaz-Pichardo
Ethnopharmacological importance: Kalanchoe flammea Stapf (Crassulaceae) is a medicinal plant grown in the South of Mexico (State of Tabasco), which is commonly used in traditional medicine for the treatment of fever, wounds, inflammation, and cancer. AIM OF THE STUDY: To establish the potential of K. flammea for the treatment of prostate cancer, evaluating its cytotoxic activity, its probable mechanism of action, and carrying out some toxicological safety studies. MATERIALS AND METHODS: The cytotoxic activity of the ethyl acetate extract of K...
May 3, 2018: Journal of Ethnopharmacology
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