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https://www.readbyqxmd.com/read/28343145/effects-of-tiletamine-on-the-adenosine-monophosphate-activated-protein-kinase-signaling-pathway-in-the-rat-central-nervous-system
#1
Li-Xue Su, Xing-Xing Shi, Peng Yang, Hao Chen, Xin Li, Hong-Gang Fan, Hong-Bin Wang
OBJECTIVE: The dissociative anesthetic tiletamine, which acts on the central nervous system (CNS), is widely used in veterinary medicine and animal experiments. Recent studies indicate that adenosine 5'-monophosphate activated protein kinase (AMPK) plays a key role in the analgesic action of tiletamine. In the present study, the effects of tiletamine on the AMPK signaling pathway in rats were investigated. METHODS: Sprague-Dawley rats were injected intraperitoneally with tiletamine and executed at 10, 20, 40 and 60min post injection...
March 21, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28343042/in-situ-determination-of-trace-elements-in-fucus-spp-by-field-portable-xrf
#2
Andrew Turner, Hiu Poon, Alex Taylor, Murray T Brown
Fresh and freeze-dried sample sections of the coastal macroalgae, Fucus serratus and F. vesiculosus, and the brackish water macroalga, F. ceranoides, have been analysed for trace elements by field-portable-X-ray fluorescence (FP-XRF) spectrometry using a Niton XL3t in a low density mode with thickness correction. When analysed fresh in a laboratory accessory stand for a period of 200 seconds, As, Br, Fe and Zn were registered in the apex, mid-frond and lower stipe of all species, with detection limits of a few μg g(-1) (As) or a few tens of μg g(-1) (Br, Fe, Zn); when analysed dry under the same conditions, concentrations returned were systematically higher and Cu and Pb were detected in a number of F...
March 23, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28342865/kshv-encoded-viral-interferon-regulatory-factor-4-virf4-interacts-with-irf7-and-inhibits-interferon-alpha-production
#3
Sung-Woo Hwang, DongIk Kim, Jae U Jung, Hye-Ra Lee
Before an infection can be completely established, the host immediately turns on the innate immune system through activating the interferon (IFN)-mediated antiviral pathway. Kaposi's sarcoma-associated herpesvirus (KSHV) utilizes a unique antagonistic mechanism of type I IFN-mediated host antiviral immunity by incorporating four viral interferon regulatory factors (vIRF1-4). Herein, we characterized novel immune evasion strategies of vIRF4 to inhibit the IRF7-mediated IFN-α production. KSHV vIRF4 specifically interacts with IRF7, resulting in inhibition of IRF7 dimerization and ultimately suppresses IRF7-mediated activation of type I IFN...
March 22, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28342848/ultraviolet-a-induced-oxidation-in-cornea-characterization-of-the-early-oxidation-related-events
#4
Corinne Zinflou, Patrick J Rochette
Exposure to sunlight ultraviolet-A (UVA), the main component of solar UV reaching the eyes, is suspected to play an important part in the onset of ocular pathologies. UVA primary biological deleterious effects arise from the photo-induction of oxidative stress in cells. However, the molecular bases linking UVA-induced oxidation to UVA toxicity in eyes remain poorly understood, especially with regards to the cornea. To shed some light on this issue, we have investigated the susceptibility and response potential of the different corneal cellular layers (epithelium, stroma and endothelium) to UVA-induced oxidation...
March 22, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28342830/patients-taking-amoxicillin-clavulanic-can-become-simultaneously-sensitized-to-both-drugs
#5
María Salas, Jose Julio Laguna, Inmaculada Doña, Esther Barrionuevo, Rubén Fernandez-Santamaría, Adriana Ariza, Ezequiel Perez-Inestrosa, Cristobalina Mayorga, Tahia Diana Fernández, María José Torres
BACKGROUND: Patients can react to amoxicillin (AX) and clavulanic acid (CLV) taken in combination because of selective reactions to either drug. However, scant information exists concerning patients who react simultaneously to both compounds. OBJECTIVE: To analyze the mechanisms involved in 4 patients who developed allergic reactions to AX-CLV administration (3 with immediate IgE-mediated reaction and 1 with nonimmediate T-cell-mediated reaction) and who responded specifically to both AX and CLV...
March 22, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28342774/hypercapnia-induced-brain-acidosis-effects-and-putative-mechanisms-on-acute-kainate-induced-seizures
#6
Xiu-Yu Shi, Lin-Yan Hu, Meng-Jia Liu, Li-Ping Zou
AIMS: This study investigated the mechanism of the anticonvulsant effects of carbogen containing 5% CO2 in a kainic acid (KA) rat model. MAIN METHODS: Four-week-old Sprague-Dawley rats were divided into four groups: control, carbogen, KA+air, and KA+carbogen. Carbogen containing 5% CO2 was applied immediately after KA injection, and cortical pH was recorded. High-performance liquid chromatography was used to detect the release of γ-aminobutyric acid (GABA) and glutamate...
March 22, 2017: Life Sciences
https://www.readbyqxmd.com/read/28342739/supervised-physical-therapy-vs-home-exercise-program-for-patients-with-distal-radius-fracture-a-single-blind-randomized-clinical-study
#7
Héctor Gutiérrez-Espinoza, David Rubio-Oyarzún, Cristian Olguín-Huerta, Rodrigo Gutiérrez-Monclus, Sebastian Pinto-Concha, Gonzalo Gana-Hervias
STUDY DESIGN: Randomized clinical study. INTRODUCTION: Supervised physical therapy (PT) and home exercise programs (HEPs) are frequently used in the rehabilitation of patients with distal radius fracture (DRF). However, there is no consensus as to whether unsupervised HEP provides comparable benefits to those achieved by supervised PT. PURPOSE OF THE STUDY: To compare the improvements in pain and functional status between a supervised PT program and unsupervised HEP in DRF patients older than 60 years...
March 22, 2017: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/28342738/american-brachytherapy-society-consensus-statement-for-soft-tissue-sarcoma-brachytherapy
#8
A O Naghavi, D C Fernandez, N Mesko, A Juloori, A Martinez, J G Scott, C Shah, L B Harrison
PURPOSE: Radiation therapy represents an essential treatment option in the management of soft tissue sarcomas (STS). Brachytherapy represents an important subset of radiation therapy techniques used for STS, with evolving indications and applications. Therefore, the purpose of this guideline was to update clinicians regarding the data surrounding brachytherapy (BT) and provide recommendations for the utilization of BT in patients with STS. METHODS AND MATERIALS: Members of the American Brachytherapy Society with expertise in STS, and STS BT in particular, created an updated guideline for the use of BT in STS based on a literature review and clinical experience...
March 22, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28342720/rebubbling-in-descemet-membrane-endothelial-keratoplasty-influence-of-pressure-and-duration-of-the-intracameral-air-tamponade
#9
Daniel Pilger, Ina Wilkemeyer, Jan Schroeter, Anna-Karina B Maier, Necip Torun
PURPOSE: To explore the impact of intracameral air tamponade pressure and duration on graft attachment and rebubbling rates. DESIGN: A prospective, interventional, non-randomized study METHODS: Setting: Charité - Universitätsmedizin Berlin, department of ophthalmology STUDY POPULATION: 117 patients who underwent Descemet membrane endothelial keratoplasty (DMEK) OBSERVATION: Intraocular pressure (IOP) at the end of the surgery, immediately after filling the anterior chamber with air, categorized into low (<10mmHg), normal (10-20mmHg) and high (>20mmHg) and the time until partial removal of the air...
March 22, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28342716/immediate-postpartum-intrauterine-device-and-implant-program-outcomes-a-prospective-analysis
#10
Jennifer L Eggebroten, Jessica N Sanders, David K Turok
BACKGROUND: In-hospital placement of intrauterine devices (IUD) and contraceptive implants following vaginal and cesarean delivery is increasingly popular and responds to maternal motivation for highly effective postpartum contraception. Immediate postpartum IUD insertion is associated with higher expulsion than interval placement, but emerging evidence suggests that the LNG IUD may have a higher expulsion rate than the Cu IUD. OBJECTIVE: This study evaluated in-hospital provision, expulsion and six month continuation of immediate postpartum copper T380 IUDs (Cu IUD), levonorgestrel (LNG) IUDs, and contraceptive implants...
March 22, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28342682/a-home-program-of-strength-training-movement-strategy-training-and-education-did-not-prevent-falls-in-people-with-parkinson-s-disease-a-randomised-trial
#11
Meg E Morris, Nicholas F Taylor, Jennifer Watts, Andrew Evans, Malcolm Horne, Peter Kempster, Mary Danoudis, Jennifer J McGinley, Clarissa Martin, Hylton B Menz
QUESTIONS: For people with idiopathic Parkinson's disease, does a 6-week, comprehensive, home exercise program reduce falls and disability and improve health-related quality of life? Is the program cost-effective? DESIGN: Randomised, controlled trial with concealed allocation and assessor blinding. PARTICIPANTS: One hundred and thirty-three community-dwelling adults with Parkinson's disease. INTERVENTION: The experimental group completed a 6-week home program comprising progressive resistance strength training, movement strategy training and falls education...
March 14, 2017: Journal of Physiotherapy
https://www.readbyqxmd.com/read/28342652/effective-hospital-wide-education-in-hemorrhage-control
#12
James R Hegvik, Sarah K Spilman, Sherry D Olson, Carrie A Gilchrist, Richard A Sidwell
BACKGROUND: Uncontrolled hemorrhage is the leading cause of potentially preventable traumatic death. Bleeding victims must receive immediate medical attention to save lives, and the first opportunity to control bleeding after trauma often comes from bystanders. Educating the general public is important for improving outcomes for hemorrhaging victims, and it is imperative for all people, including those with no clinical training, to have the knowledge to respond until trained medical specialists arrive...
March 4, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28340430/bilateral-sequential-motor-cortex-stimulation-and-skilled-task-performance-with-non-dominant-hand
#13
Milan B Jelić, Saša R Filipović, Sladjan D Milanović, Vuk B Stevanović, Ljubica Konstantinović
OBJECTIVE: To check whether bilateral sequential stimulation (BSS) of M1 with theta burst stimulation (TBS), using facilitatory protocol over non-dominant M1 followed by inhibitory one over dominant M1, can improve skilled task performance with non-dominant hand more than either of the unilateral stimulations do. Both, direct motor cortex (M1) facilitatory non-invasive brain stimulation (NIBS) and contralateral M1 inhibitory NIBS were shown to improve motor learning. METHODS: Forty right-handed healthy subjects were divided into 4 matched groups which received either ipsilateral facilitatory (intermittent TBS [iTBS] over non-dominant M1), contralateral inhibitory (continuous TBS [cTBS] over dominant M1), bilateral sequential (contralateral cTBS followed by ipsilateral iTBS), or placebo stimulation...
March 6, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28340392/-237-np-analytical-method-using-239-np-tracers-and-application-to-a-contaminated-nuclear-disposal-facility
#14
Mathew S Snow, Samuel S Morrison, Sue B Clark, John E Olson, Matthew G Watrous
Environmental (237)Np analyses are challenged by low (237)Np concentrations and lack of an available yield tracer; we report a rapid, inexpensive (237)Np analytical approach employing the short lived (239)Np (t1/2 = 2.3 days) as a chemical yield tracer followed by (237)Np quantification using inductively coupled plasma-mass spectrometry. (239)Np tracer is obtained via separation from a (243)Am stock solution and standardized using gamma spectrometry immediately prior to sample processing. Rapid digestions using a commercial, 900 W "Walmart" microwave and Parr microwave vessels result in 99...
March 21, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28340389/minilaparotomy-without-general-anesthesia-for-the-treatment-of-sigmoid-volvulus-in-high-risk-patients-a-case-series-of-4-patients
#15
Ernesto L Enrique, Kareem A Hamdy
BACKGROUND: Sigmoid volvulus (SV) is a common cause of large bowel obstruction worldwide. Presenting symptoms can be nonspecific and varied amongst the elderly population, making medical and surgical management challenging. This population is at markedly increase risk of complications and mortality with surgery under general anesthesia. In this case series, we describe 4 cases of sigmoid volvulus in octogenarians. GOALS: To demonstrate that sigmoid colectomy under local anesthesia, with or without intravenous conscious sedation, is feasible and can be done safely and with a low rate of converting to a general anesthetic...
March 2, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28340174/application-of-virtual-navigation-with-multimodality-image-fusion-in-foramen-ovale-cannulation
#16
Xixiong Qiu, Weizong Liu, Mingdong Zhang, Hengzhou Lin, Shoujun Zhou, Yi Lei, Jun Xia
Objective. : Idiopathic trigeminal neuralgia (ITN) can be effectively treated with radiofrequency thermocoagulation. However, this procedure requires cannulation of the foramen ovale, and conventional cannulation methods are associated with high failure rates. Multimodality imaging can improve the accuracy of cannulation because each imaging method can compensate for the drawbacks of the other. We aim to determine the feasibility and accuracy of percutaneous foramen ovale cannulation under the guidance of virtual navigation with multimodality image fusion in a self-designed anatomical model of human cadaveric heads...
March 6, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28340109/mth1-an-8-oxo-2-deoxyguanosine-triphosphatase-and-myh-a-dna-glycosylase-cooperate-to-inhibit-mutations-induced-by-chronic-exposure-to-oxidative-stress-of-ionising-radiation
#17
Sara Shakeri Manesh, Traimate Sangsuwan, Ali Pour Khavari, Asal Fotouhi, S Noushin Emami, Siamak Haghdoost
Our previous results showed that in addition to the immediate interaction of ionising radiation with DNA (direct and indirect effect), low-dose and chronic low-dose rate of irradiation induce endogenous oxidative stress. During oxidative stress, free radicals react with DNA, nucleoside triphosphates (dNTPs), proteins and lipids, and modify their structures. The MYH and MTH1 genes play important roles in preventing mutations induced by 8-hydroxy-guanine, which is an oxidised product of guanine. In this study, we used short-hairpin RNA to permanently knockdown MYH and MTH1 proteins in human lymphoblastoid TK6 cells...
March 16, 2017: Mutagenesis
https://www.readbyqxmd.com/read/28340091/effect-of-antimicrobial-treatment-on-the-resolution-of-middle-ear-effusion-after-acute-otitis-media
#18
Aino Ruohola, Miia K Laine, Paula A Tähtinen
Background.: Acute otitis media (AOM) induces middle-ear effusion (MEE), which affects hearing. The effect of antimicrobial treatment on the resolution of MEE is controversial, and the factors that affect resolution are unknown. Methods.: We studied the effect of antimicrobial treatment on the time to the resolution of MEE as a secondary objective in our randomized double-blind placebo-controlled trial. Children aged 6 to 35 months with stringently diagnosed AOM were allocated to receive amoxicillin-clavulanate (161 patients) or placebo (158 patients) for 7 days and closely followed for 3 months...
March 16, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28339904/validity-of-different-activity-monitors-to-count-steps-in-an-inpatient-rehabilitation-setting
#19
Daniel Treacy, Leanne Hassett, Karl Schurr, Sakina Chagpar, Serene S Paul, Catherine Sherrington
Background: Commonly used activity monitors have been shown to be accurate in counting steps in active people, however, further validation is needed in slower walking populations. Objectives: To determine the validity of activity monitors for measuring step counts in rehabilitation inpatients compared to visually-observed step counts. To explore the influence of gait parameters, activity monitor position and use of walkers on activity monitor accuracy. Methods: 166 inpatients admitted to a rehabilitation unit with an average walking speed of 0...
March 2, 2017: Physical Therapy
https://www.readbyqxmd.com/read/28339754/expression-of-deep-brain-photoreceptors-in-the-pekin-drake-a-possible-role-in-the-maintenance-of-testicular-function
#20
R Haas, E Alenciks, S Meddle, G S Fraley
Several putative deep brain photoreceptors (DBPs) have been identified, such as melanopsin, opsin 5, and vertebrate ancient opsin. The aim of this study was to elucidate the role of DBPs in gonadal regulation in the Pekin drake. As previously reported, we observed opsin-like immunoreactivity (-ir) in the lateral septum (LS), melanopsin-ir in the premammillary nucleus (PMM), and opsin 5-ir in the periventricular organ. To determine the sensitivity of the DBPs to specific wavelengths of light, drakes were given an acute exposure to red, blue, or white light...
February 23, 2017: Poultry Science
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