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https://www.readbyqxmd.com/read/28545280/-impacts-of-early-metoprolol-intervention-on-connexin-43-and-phosphorylated-connexin-43-expression-in-rabbits-with-experimental-myocardial-infarction
#1
M Zhou, Q Lu, J Q Jiang, Z N Chen, Z G Gong, Z G Li, W W Fu, S F Ding
Objective: To investigate the early intervention effects of metoprolol on connexin 43(Cx43) and phosphorylated Cx43 (p-Cx43) expression in rabbits with post myocardial infarction. Methods: A total of 24 adult male New Zealand white rabbits were divided into sham group (n=6), early treatment group(n=6), routine treatment group(n=6), and myocardial infarction group(n=6) with a randomized block design blocked by weight. Myocardial infarction was induced by left anterior descending coronary artery (LAD) ligation...
April 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/28545277/-effect-of-the-ischemic-post-conditioning-on-the-prevention-of-the-cardio-renal-damage-in-patients-with-acute-st-segment-elevation-myocardial-infarction-after-primary-percutaneous-coronary-intervention
#2
Y Y Wang, T Li, Y W Liu, B J Liu, X M Hu, Y Wang, W Q Gao, P Wu, L Huang, X Li, W J Peng, M Ning
Objective: To evaluate the effect of the ischemic post-conditioning (IPC) on the prevention of the cardio-renal damage in patients with acute ST-segment elevation myocardial infarction (STEMI) after primary percutaneous coronary intervention (PPCI). Methods: A total of 251 consecutive STEMI patients underwent PPCI in the heart center of Tianjin Third Central Hospital from January 2012 to June 2014 were enrolled in this prospective, randomized, control, single-blinded, clinical registry study. Patients were randomly divided into IPC group (123 cases) and control group (128 cases) with random number table...
April 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/28545157/the-aminoestrogen-prolame-increases-recognition-memory-and-hippocampal-neuronal-spine-density-in-aged-mice
#3
Alfonso Diaz, Samuel Treviño, Rubén Vázquez-Roque, Berenice Venegas, Blanca Espinosa, Gonzalo Flores, Juan Manuel Fernández-G, Luis F Montaño, Jorge Guevara
The aging brain shows biochemical and morphological changes in the dendrites of pyramidal neurons from the limbic system associated with memory loss. Prolame (N-(3-hydroxy-1,3,5 (10) -estratrien-17β-yl) -3-hydroxypropylamine) is a non-feminizing aminoestrogen with antithrombotic activity that prevents neuronal deterioration, oxidative stress and neuroinflammation. Our aim was to evaluate the effect of prolame on motor and cognitive processes, as well as its influence on the dendritic morphology of neurons at the CA1, CA3 and granule cells of the dentate gyrus (DG) regions of hippocampus (HP), and medium spiny neurons of the nucleus accumbens (NAcc) of aged mice...
May 25, 2017: Synapse
https://www.readbyqxmd.com/read/28545082/clinical-endoscopic-management-and-outcome-of-post-endoscopic-sphincterotomy-bleeding
#4
Wei-Chen Lin, Hsaing-Hung Lin, Chien-Yuan Hung, Shou-Chuan Shih, Cheng-Hsin Chu
Post-endoscopic sphincterotomy bleeding is a common complication of biliary sphincterotomy, and the incidence varies from 1% to 48%. It can be challenging to localize the bleeder or to administer various interventions through a side-viewing endoscope. This study aimed to evaluate the risk factors of post-endoscopic sphincterotomy bleeding and the outcome of endoscopic intervention therapies. We retrospectively reviewed the records of 513 patients who underwent biliary sphincterotomy in Mackay Memorial Hospital between 2011 and 2016...
2017: PloS One
https://www.readbyqxmd.com/read/28545075/an-improved-ant-colony-optimization-algorithm-with-fault-tolerance-for-job-scheduling-in-grid-computing-systems
#5
Hajara Idris, Absalom E Ezugwu, Sahalu B Junaidu, Aderemi O Adewumi
The Grid scheduler, schedules user jobs on the best available resource in terms of resource characteristics by optimizing job execution time. Resource failure in Grid is no longer an exception but a regular occurring event as resources are increasingly being used by the scientific community to solve computationally intensive problems which typically run for days or even months. It is therefore absolutely essential that these long-running applications are able to tolerate failures and avoid re-computations from scratch after resource failure has occurred, to satisfy the user's Quality of Service (QoS) requirement...
2017: PloS One
https://www.readbyqxmd.com/read/28544945/longitudinal-association-between-diabetes-and-cognitive-decline-the-national-health-and-aging-trends-study
#6
Alexandra M V Wennberg, Clinton E Hagen, Rebecca F Gottesman, Vadim Zipunnikov, Christopher N Kaufmann, Marilyn S Albert, George W Rebok, Judith D Kasper, Adam P Spira
Type II diabetes mellitus (DM) is associated with increased risk of dementia; however, few studies have examined the longitudinal association between DM and cognitive outcomes in large nationally representative cohorts. We investigated these associations in 7605 participants enrolled in the National Health and Aging Trends Study, a nationally representative prospective study of Medicare beneficiaries ≥65, from 2011 to 2015. Participants or proxy respondents reported DM and dementia diagnosis, and participants completed immediate and delayed recall word list learning tests and the Clock Drawing Test...
May 16, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28544827/procedural-techniques-for-the-management-of-severe-transvalvular-and-paravalvular-aortic-regurgitation-during-tavr
#7
Abdulla A Damluji, Carlos E Alfonso, Mauricio G Cohen
Aortic regurgitation (AR) after transcatheter aortic valve replacement (TAVR) is associated with an increased risk of mortality. In severe cases, abrupt hemodynamic changes may occur with a sudden increase in left ventricular end-diastolic pressure that results in frank pulmonary edema, hypoxia, and cardiogenic shock. Here, the case is reported of a patient who developed severe AR immediately after valve deployment that led to severe hemodynamic compromise. The procedural techniques necessary for the immediate management of severe transvalvular and paravalvular AR are described...
January 2017: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/28544784/presynaptic-congenital-myasthenic-syndrome-with-a-homozygous-sequence-variant-in-lama5-combines-myopia-facial-tics-and-failure-of-neuromuscular-transmission
#8
Ricardo A Maselli, Juan Arredondo, Jessica Vázquez, Jessica X Chong, Michael J Bamshad, Deborah A Nickerson, Marian Lara, Fiona Ng, Victoria L Lo, Peter Pytel, Craig M McDonald
Defects in genes encoding the isoforms of the laminin alpha subunit have been linked to various phenotypic manifestations, including brain malformations, muscular dystrophy, ocular defects, cardiomyopathy, and skin abnormalities. We report here a severe defect of neuromuscular transmission in a consanguineous patient with a homozygous variant in the laminin alpha-5 subunit gene (LAMA5). The variant c.8046C>T (p.Arg2659Trp) is rare and has a predicted deleterious effect. The affected individual, who also carries a rare homozygous sequence variant in LAMA1, had muscle weakness, myopia, and facial tics...
May 25, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28544689/class-ii-obese-and-healthy-pregnant-controls-exhibit-indistinguishable-pro-and-anti-inflammatory-immune-responses-to-caesarian-section
#9
Caroline Graham, Mullein Thorleifson, William P Stefura, Duane J Funk, Kent T HayGlass
INTRODUCTION: Obesity during pregnancy is associated with meta-inflammation and an increased likelihood of clinical complications. Surgery results in intense, acute inflammatory responses in any individual. Because obese individuals exhibit constitutive inflammatory responses and high rates of Caesarian section, it is important to understand the impact of surgery in such populations. Whether more pronounced pro-inflammatory cytokine responses and/or counterbalancing changes in anti-inflammatory immune modulators occurs is unknown...
May 25, 2017: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/28544665/humidified-high-flow-nasal-cannula-oxygen-in-bronchiolitis-reduces-need-for-invasive-ventilation-but-not-intensive-care-admission
#10
Chong Tien Goh, Lynette J Kirby, David N Schell, Jonathan R Egan
AIM: To describe the changes to paediatric intensive care unit (PICU) admission patterns and ventilation requirements for children with bronchiolitis following the introduction of humidified high-flow nasal cannula oxygen outside the PICU. METHODS: Retrospective study comparing patients <24 months of age with a discharge diagnosis of bronchiolitis admitted to the PICU. A comparison was made between those before humidified high-flow nasal cannula oxygen use (year 2008) to those immediately following the introduction of humidified high-flow nasal cannula oxygen use (year 2011) and those following further consolidation of humidified high-flow nasal cannula oxygen use outside the PICU (year 2013)...
May 23, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/28544659/intranasal-distribution-and-clearance-of-thermoreversible-gel-in-an-animal-model
#11
Ji Eun Choi, Ki Ryung Kim, Yangseop Noh, Won-Ho Chung, Yang-Sun Cho, Seung-Kyu Chung, Hun-Jong Dhong, Hyo Yeol Kim
BACKGROUND: Poloxamer 407 (P407) has been investigated for an intranasal drug delivery system. However, there is little known about the distribution and clearance of intranasally applied P407. The purpose of this study was to evaluate the distribution and clearance time of P407 in an animal model. METHODS: Five male pigs were administered the experimental solution (18% of P407 with 0.01% of fluorescein) and the control solution (normal saline with 0.01% of fluorescein) into their right and left nasal cavity, respectively...
May 23, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28544648/effects-of-a-web-based-patient-decision-aid-on-biologic-and-small-molecule-agents-for-rheumatoid-arthritis-answer-2-a-proof-of-concept-study
#12
Linda C Li, Chris Shaw, Diane Lacaille, Elaine Yacyshyn, C Allyson Jones, Cheryl Koehn, Alison M Hoens, Jasmina Geldman, Eric C Sayre, Graham Macdonald, Jenny Leese, Nick Bansback
OBJECTIVES: To assess the extent to which ANSWER-2, an interactive online patient decision aid, reduces patients' decisional conflict and improves their medication-related knowledge and self-management capacity. METHODS: We used a pre-post study design. Eligible participants had a diagnosis of rheumatoid arthritis (RA), had been recommended to start using a biologic or small molecule agent or to switch to a new one, and had Internet access. Access to ANSWER-2 was provided immediately after enrollment...
May 23, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28544640/an-in%C3%A2-vitro-model-demonstrates-the-potential-of-neoplastic-human-germ-cells-to-influence-the-tumour-microenvironment
#13
B Klein, H-C Schuppe, M Bergmann, M P Hedger, B E Loveland, K L Loveland
Testicular germ cell tumours (TGCT) typically contain high numbers of infiltrating immune cells, yet the functional nature and consequences of interactions between GCNIS (germ cell neoplasia in situ) or seminoma cells and immune cells remain unknown. A co-culture model using the seminoma-derived TCam-2 cell line and peripheral blood mononuclear cells (PBMC, n = 7 healthy donors) was established to investigate how tumour and immune cells each contribute to the cytokine microenvironment associated with TGCT...
May 23, 2017: Andrology
https://www.readbyqxmd.com/read/28544606/effects-of-tooth-storage-media-on-periodontal-ligament-preservation
#14
Md Riasat Hasan, Hiroaki Takebe, Nazmus Shalehin, Nobuko Obara, Takashi Saito, Kazuharu Irie
BACKGROUND / AIMS: An easily available tooth storage medium is required to preserve a tooth after avulsion. Milk and Hank's balanced salt solution (HBSS) are recommended as tooth storage media, and egg white is also reported to be comparable with milk. The aim of the present study was to histologically and immunohistochemically evaluate the effect of different tooth storage media on the periodontal ligament (PDL) of extracted teeth. MATERIAL AND METHODS: This experiment used HBSS, milk and egg white as tooth storage media...
May 24, 2017: Dental Traumatology: Official Publication of International Association for Dental Traumatology
https://www.readbyqxmd.com/read/28544542/conditional-macrophage-depletion-increases-inflammation-and-does-not-inhibit-the-development-of-osteoarthritis-in-obese-mafia-mice
#15
Chia-Lung Wu, Jenna McNeill, Kelsey Goon, Dianne Little, Kelly Kimmerling, Janet Huebner, Virginia Kraus, Farshid Guilak
OBJECTIVE: Macrophages are believed to play a critical role in the inflammation associated with the development of osteoarthritis (OA) in obesity. The objective of the study was to investigate whether short-term, systemic depletion of macrophages would mitigate OA following injury in obese mice. METHODS: CSF-1R-GFP(+) Macrophage Fas-Induced Apoptosis (MaFIA) transgenic mice that allow conditional depletion of macrophages were placed on a high-fat diet and underwent surgery to induce knee OA...
May 23, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28544540/serum-adrenomedullin-and-urinary-thromboxane-b2-help-early-categorizing-acute-kidney-injury-in-de-compensated-cirrhotic-patients-a-prospective-cohort-study
#16
Chih-Wei Liu, Chia-Chang Huang, Hung-Cheng Tsai, Yen-Bo Su, Shiang-Fen Huang, Kuei-Chuan Lee, Yun-Cheng Hsieh, Tzu-Hao Li, Chang-Youh Tsai, Lee-Won Chong, Shuo-Ming Ou, Ying-Ying Yang, Wen-Chien Fan, Ming-Chih Hou, Han-Chieh Lin, Shou-Dong Lee
AIMS: Increases in the systemic vasodilator adrenomedullin and the renal vasoconstrictors thromboxane A2 (TXA2 ) in cirrhotic patients are pathogenic factors for the development of functional acute-kidney-injury, including pre-renal azotemia (PRA) and hepatorenal syndrome (HRS), which is associated with high mortality. This study aims to find biomarkers which can diagnose HRS in early stage for treating it as soon as possible. METHODS: Acute decompensated cirrhotic patients who had been admitted to hospital were enrolled in this prospective cohort study...
May 20, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28544508/enhancement-of-plasma-protein-adsorption-and-osteogenesis-of-hmscs-by-functionalized-siloxane-coatings-for-titanium-implants
#17
Maria Martínez-Ibáñez, N Sanjeeva Murthy, Yong Mao, Julio Suay, Marilo Gurruchaga, Isabel Goñi, Joachim Kohn
A series of sol-gel derived silicon based coatings were developed to improve the osseointegration of commercial titanium dental implants. The osseointegration starts with a positive interaction between the implant surface and surrounding tissues, which is facilitated by the adsorption of plasma proteins onto the biomaterial surface immediately after implantation. It is likely that the enhancement of protein adsorption to titanium implants leads to a better implant/tissue integration. In addition, silica based biomaterials have been shown to promote osteoblast differentiation...
May 25, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28544470/patients-help-seeking-experiences-and-delaying-in-breast-cancer-diagnosis-a-qualitative-study
#18
Mariko Oshiro, Midori Kamizato
AIM: To identify the influencing factors in help-seeking behavior by comparing delayers with non-delayers in Japanese female patients with breast cancer. METHODS: This is a descriptive qualitative study. A total of 21 female patients with breast cancer (nine delayers and 12 non-delayers) who were at least 3 months to 5 years postdiagnosis were recruited from two hospitals in Okinawa, Japan. Semistructured interviews were carried out and the results were analyzed by using a qualitative inductive approach...
May 23, 2017: Japan Journal of Nursing Science: JJNS
https://www.readbyqxmd.com/read/28544393/comparison-of-5-year-oncological-outcomes-of-breast-cancer-based-on-surgery-type
#19
Jeeyeon Lee, Jin Hyang Jung, Wan Wook Kim, Yee Soo Chae, Soo Jung Lee, Ho Yong Park
BACKGROUND: A standardized classification system for breast surgery that incorporates oncoplastic techniques is needed. We classified the surgical techniques for breast cancer treatment into five groups according to the extent of surgery and reconstructive methods, i.e. conventional breast-conserving surgery, partial mastectomy with volume displacement, partial mastectomy with volume replacement, simple mastectomy and total mastectomy with immediate reconstruction. We then evaluated the oncological outcomes for each of the five groups...
May 21, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28544379/a-widened-substrate-selectivity-filter-of-eukaryotic-formate-nitrite-transporters-enables-high-level-lactate-conductance
#20
Marie Wiechert, Holger Erler, André Golldack, Eric Beitz
Bacterial formate-nitrite transporters (FNT) regulate the metabolic flow of small weak mono-acids derived from anaerobic mixed-acid fermentation, such as formate, and further transport nitrite, and hydrosulfide. The eukaryotic Plasmodium falciparum FNT is vital for the malaria parasite by its ability to release the larger l-lactate substrate as the metabolic end product of anaerobic glycolysis in symport with protons preventing cytosolic acidification. However, the molecular basis for substrate discrimination by FNTs has remained unclear...
May 21, 2017: FEBS Journal
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