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https://www.readbyqxmd.com/read/28110481/pregnancy-associated-transient-osteoporosis-of-the-hip-results-of-a-case-control-study
#1
Peyman Hadji, Jelena Boekhoff, Melitta Hahn, Lars Hellmeyer, Olaf Hars, Ioannis Kyvernitakis
: The etiology and underlying mechanisms of transient of osteoporosis of the hip (TOH) during pregnancy are still unclear, since no systematic analyses exist. Our results support the hypothesis that TOH is a multifactorial disease, which is associated with immobility, dental problems, and lack of exercise in childhood. INTRODUCTION: Pregnancy-associated transient osteoporosis of the hip (TOH) is a rare but severe form of osteoporosis, which may affect a subgroup of women in the last trimester of pregnancy or immediately postpartum...
December 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/28110463/biomarkers-of-renal-tumors-the-current-state-and-clinical-perspectives
#2
REVIEW
Marina O Golovastova, Dmitry O Korolev, Larisa V Tsoy, Vladimir A Varshavsky, Wan-Hai Xu, Andrey Z Vinarov, Evgeni Yu Zernii, Pavel P Philippov, Andrey A Zamyatnin
Renal cell carcinoma (RCC) ranks the first death rate among the urogenital tumors, whereas its incidence follows the incidences of prostate and bladder cancer. The diagnosis of RCC at early stages allows immediately undertaking appropriate treatment, which significantly increases patients' survival rate. Early and accurate diagnosis avoids inadequate treatment, provides the disease progression forecast, and permits to apply more efficient therapy. Unfortunately, the small renal tumors are usually asymptomatic resulting in the late diagnosis and, therefore, low efficacy of treatment...
January 2017: Current Urology Reports
https://www.readbyqxmd.com/read/28110112/verbal-memory-functioning-moderates-psychotherapy-treatment-response-for-ptsd-related-nightmares
#3
J Cobb Scott, Gerlinde Harb, Janeese A Brownlow, Jennifer Greene, Ruben C Gur, Richard J Ross
Posttraumatic stress disorder (PTSD) is associated with cognitive deficits in attention, executive control, and memory, although few studies have investigated the relevance of cognitive difficulties for treatment outcomes. We examined whether cognitive functioning and history of traumatic brain injury (TBI) were associated with response to cognitive-behavioral therapy (CBT) for PTSD-related sleep problems. In a randomized controlled trial of Imagery Rehearsal (IR) added to components of CBT for Insomnia (IR + cCBT-I) compared to cCBT-I alone for PTSD-related recurrent nightmares, 94 U...
January 13, 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/28110056/current-knowledge-and-management-of-hypersensitivity-reactions-to-monoclonal-antibodies
#4
Matthieu Picard, Violeta Régnier Galvão
Hypersensitivity reactions (HSRs) to monoclonal antibodies (mAbs) are increasingly frequent as this class of therapeutic agents is rapidly expanding. Immediate and nonimmediate HSRs have been reported with mAbs. Immediate HSRs can be explained by 3 main mechanisms: cytokine release syndrome, IgE-mediated, and IgG-mediated reactions. Importantly, IgE-mediated reactions can occur on first exposure due to preformed specific IgEs, as shown for cetuximab. Almost all patients with an immediate HSR can be safely re-exposed either through desensitization or challenge depending on the severity and mechanism of the initial reaction...
January 18, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28109988/epilepsy-and-restless-legs-syndrome
#5
James D Geyer, Emery E Geyer, Zachary Fetterman, Paul R Carney
OBJECTIVE: Restless legs syndrome (RLS) is a common neurological movement disorder occurring in approximately 10% of the general population. The prevalence of moderately severe RLS is 2.7% overall (3.7% for women and 1.7% for men). Epilepsy is also a common neurological disorder with significant associated morbidity and impact on quality of life. We evaluated the severity and frequency of primary RLS in patients with localization-related temporal lobe epilepsy (TLE) and investigated the role of prodromal RLS symptoms as a warning sign and lateralizing indicator...
January 18, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28109936/precision-phenotyping-in-heart-failure-and-pattern-clustering-of-ultrasound-data-for-the-assessment-of-diastolic-dysfunction
#6
Alaa Mabrouk Salem Omar, Sukrit Narula, Mohamed Ahmed Abdel Rahman, Gianni Pedrizzetti, Hala Raslan, Osama Rifaie, Jagat Narula, Partho P Sengupta
OBJECTIVES: The aim of this study was to investigate whether cluster analysis of left atrial and left ventricular (LV) mechanical deformation parameters provide sufficient information for Doppler-independent assessment of LV diastolic function. BACKGROUND: Medical imaging produces substantial phenotyping data, and superior computational analyses could allow automated classification of repetitive patterns into patient groups with similar behavior. METHODS: The authors performed a cluster analysis and developed a model of LV diastolic function from an initial exploratory cohort of 130 patients that was subsequently tested in a prospective cohort of 44 patients undergoing cardiac catheterization...
January 11, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28109783/the-affordable-care-act-medicaid-expansion-correlated-with-increased-heart-transplant-listings-in-african-americans-but-not-hispanics-or%C3%A2-caucasians
#7
Khadijah Breathett, Larry A Allen, Laura Helmkamp, Kathryn Colborn, Stacie L Daugherty, Prateeti Khazanie, Richard Lindrooth, Pamela N Peterson
OBJECTIVES: The aim of this study was to determine if the Affordable Care Act (ACA) Medicaid Expansion was associated with increased census-adjusted heart transplant listing rates for racial/ethnic minorities. BACKGROUND: Underinsurance limits access to transplants, especially among racial/ethnic minorities. Changes in racial/ethnic listing rates post-ACA Medicaid Expansion are unknown. METHODS: Using the Scientific Registry of Transplant Recipients, we analyzed 5,651 patients from early adopter states (implemented the ACA Medicaid Expansion by January 2014) and 4,769 patients from non-adopter states (no implementation during the study period) from 2012 to 2015...
January 11, 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/28109755/construction-of-agrobacterium-tumefaciens-mediated-tomato-black-ring-virus-infectious-cdna-clones
#8
Aleksandra Zarzyńska-Nowak, Inmaculada Ferriol, Bryce W Falk, Natasza Borodynko-Filas, Beata Hasiów-Jaroszewska
Tomato black ring virus (TBRV, genus Nepovirus) infects a wide range of economically important plants such as tomato, potato, tobacco and cucumber. Here, a successful construction of infectious full-length cDNA clones of the TBRV genomic RNAs (RNA1 and RNA2) is reported for the first time. The engineered constructs consisting of PCR-amplified DNAs were cloned into binary vector pJL89 immediately downstream of a double Cauliflower mosaic virus (CaMV) 35S promoter, and upstream of the Hepatitis delta virus (HDV) ribozyme and nopaline synthase terminator (NOS)...
January 18, 2017: Virus Research
https://www.readbyqxmd.com/read/28109602/strategies-to-gain-body-condition-score-in-pasture-based-dairy-cows-during-late-lactation-and-the-far-off-nonlactating-period-and-their-interaction-with-close-up-dry-matter-intake
#9
J R Roche, A Heiser, M D Mitchell, M A Crookenden, C G Walker, J K Kay, M Vailati Riboni, J J Loor, S Meier
In pasture-based systems, cows are generally thinner at the end of lactation than cows fed total mixed rations and, as a result, over-feeding of metabolizable energy (ME) during the far-off nonlactating period is a standard management policy to achieve optimum calving body condition score (BCS). An alternative would be to manage cows to gain BCS through late lactation, such that cows ended lactation close to optimum calving BCS and maintenance of BCS through to calving. We sought to quantify the effect of moderate or excessive ME intakes during the far-off nonlactating period in cows that had been managed to gain or maintain BCS through late lactation and whether the far-off management strategy interacted with close-up level of feeding...
January 18, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28109470/the-fate-of-the-free-flap-pedicle-after-free-tissue-transfer-to-the-head-and-neck-area
#10
Maarten L V Van Genechten, Martin D Batstone
OBJECTIVES: Little is understood about what happens to the vascular pedicle following free tissue transfer in the head and neck region. The viability of a free flap completely depends on the vascular supply by its vascular pedicle until neovascularization occurs from surrounding tissues. The aim of this study is to find out how long a vascular pedicle lasts following free tissue transfer in the head and neck region. MATERIALS AND METHODS: Patients were recruited from the Maxillofacial Unit at the Royal Brisbane & Women's Hospital...
February 2017: Oral Oncology
https://www.readbyqxmd.com/read/28109258/effect-of-erythropoietin-in-patients-with-acute-myocardial-infarction-five-year-results-of-the-revival-3-trial
#11
Birgit Steppich, Philip Groha, Tareq Ibrahim, Heribert Schunkert, Karl-Ludwig Laugwitz, Martin Hadamitzky, Adnan Kastrati, Ilka Ott
BACKGROUND: Erythropoietin (EPO) has been suggested to promote cardiac repair after MI. However, the randomized, double-blind, placebo controlled REVIVAL-3 trial showed that short term high dose EPO in timely reperfused myocardium does not improve left ventricular ejection fraction after 6 months. Moreover, the study raised safety concerns due to a trend towards a higher incidence of adverse clinical events as well as a increase in neointima formation after treatment with EPO. The present study therefore aimed to assess the 5-year clinical outcomes...
January 21, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28109172/integrated-treatment-options-for-male-perpetrators-of-intimate-partner-violence
#12
Cory A Crane, Caroline J Easton
ISSUES: Male-to-female intimate partner violence remains a worldwide public health issue with adverse physical and psychological consequences for victims, perpetrators and children. Personality disorders, addiction, trauma and mood symptoms are established risk factors for intimate partner violence perpetration and factor prominently into a recovery-oriented treatment approach. APPROACH: We reviewed the partner violence literature for detailed reports of traditional as well as innovative, integrated treatment approaches...
January 21, 2017: Drug and Alcohol Review
https://www.readbyqxmd.com/read/28109122/bleeding-in-the-retroperitoneal-space-under-the-broad-ligament-as-a-result-of-uterine-perforation-after-dilatation-and-curettage-report-of-a-case
#13
Hisato Tokuda, Satoshi Nakago, Hiroki Kato, Tetsuya Oishi, Fumikazu Kotsuji
Uterine perforation, a complication of dilation and curettage, is typically recognized immediately after the procedure by clinical symptoms of peritoneal irritation resulting from intraperitoneal bleeding. Our patient complained of having an uncomfortable feeling, slight dizziness, palpitation in the sitting position and abdominal discomfort but did not show signs of peritoneal irritation 24 h after dilation and curettage. However, she suddenly complained of abdominal pain. Tenderness and rebound tenderness were detected at the lower abdominal wall...
January 21, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28108966/breast-reconstruction-and-postmastectomy-radiotherapy-complications-by-type-and-timing-and-other-problems-in-radiation-oncology
#14
Kenji Sekiguchi, Jiro Kawamori, Hideko Yamauchi
Breast reconstruction (BR) represents a suitable option for women who are not expected to require postmastectomy radiotherapy (PMRT). As recent evidence has led to an extension of the indications for PMRT, this has also appeared to increase the incidence of reconstructive complications. Nevertheless, in the USA at least, trends towards BR are changing. The frequency of immediate reconstruction continues to increase, even in the setting of PMRT. In immediate implant-based reconstruction, a staged approach is preferred...
January 20, 2017: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/28108953/predictors-of-early-restenosis-after-intracardiac-echocardiography-guided-antegrade-balloon-aortic-valvuloplasty-in-high-risk-or-inoperable-patients
#15
Shinobu Hosokawa, Yoshikazu Hiasa, Akiho Seno, Tatuo Yasuoka, Tomoko Izumi, Riyo Ogura
Antegrade balloon aortic valvuloplasty (BAV) may be more effective than retrograde BAV. However, early restenosis is found inconstantly within three months after BAV. To evaluate the factor of ER after intracardiac echocardiogram (ICE) guided Antegrade BAV, fifty patients with severe aortic stenosis (AS) underwent BAV procedures with ICE. ER was defined as mean aortic valve pressure gradient (PG) >40 mmHg. During one-year follow-up period, 6 patients died and 2 patients underwent aortic valve replacement...
January 20, 2017: Cardiovascular Intervention and Therapeutics
https://www.readbyqxmd.com/read/28108946/in-vivo-neuroimaging-and-behavioral-correlates-in-a-rat-model-of-chemotherapy-induced-cognitive-dysfunction
#16
Robert L Barry, Nellie E Byun, M Noor Tantawy, Chase A Mackey, George H Wilson, Adam J Stark, Michael P Flom, Laura C Gee, C Chad Quarles
Adjuvant chemotherapy has been used for decades to treat cancer, and it is well known that disruptions in cognitive function and memory are common chemotherapeutic adverse effects. However, studies using neuropsychological metrics have also reported group differences in cognitive function and memory before or without chemotherapy, suggesting that complex factors obscure the true etiology of chemotherapy-induced cognitive dysfunction (CICD) in humans. Therefore, to better understand possible mechanisms of CICD, we explored the effects of CICD in rats through cognition testing using novel object recognition (NOR) and contextual fear conditioning (CFC), and through metabolic neuroimaging via [(18)F]fluorodeoxyglucose (FDG) positron emission tomography (PET)...
January 20, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28108933/modelling-genome-wide-topological-associating-domains-in-mouse-embryonic-stem-cells
#17
REVIEW
Y Zhan, L Giorgetti, G Tiana
Chromosome conformation capture (3C)-based techniques such as chromosome conformation capture carbon copy (5C) and Hi-C revealed that the folding of mammalian chromosomes is highly hierarchical. A fundamental structural unit in the hierarchy is represented by topologically associating domains (TADs), sub-megabase regions of the genome within which the chromatin fibre preferentially interacts. 3C-based methods provide the mean contact probabilities between chromosomal loci, averaged over a large number of cells, and do not give immediate access to the single-cell conformations of the chromatin fibre...
January 20, 2017: Chromosome Research
https://www.readbyqxmd.com/read/28108860/early-cardioversion-in-atrial-fibrillation-earlier-is-better-but-not-always-and-maybe-not-immediately
#18
REVIEW
Paloma G Piña, Alexandru B Chicos
Atrial fibrillation (AF) is the most common cardiac arrhythmia in humans. One of its important features is the tendency to become more persistent over time, even in the absence of underlying progressive heart disease. Conversion and maintenance of sinus rhythm by pharmacological or electrical methods become increasingly difficult the longer the arrhythmia persists. Electrical, mechanical, structural, and autonomic remodeling processes have been implicated in the mechanisms of AF initiation, perpetuation, and progression...
January 2017: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/28108856/diagnosis-and-management-for-trigeminal-neuralgia-caused-solely-by-venous-compression
#19
Takuro Inoue, Hisao Hirai, Ayako Shima, Fumio Suzuki, Takanori Fukushima, Masayuki Matsuda
BACKGROUND: Trigeminal neuralgia (TN) caused solely by venous compression is uncommon. An appropriate vein management protocol for microvascular decompression (MVD) has not been established. We evaluated the management of veins for TN solely due to venous involvement. METHOD: We analyzed 31 patients with TN in whom only veins were manipulated during MVD. The culprit veins smaller in diameter than the vein of the cerebellopontine fissure (VCPF) were coagulated and divided in 20 patients (divided group), while transposition was performed for larger veins in the remaining 11 patients (non-divided group)...
January 20, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28108831/the-effect-of-mouth-prop-on-endotracheal-tube-intracuff-pressure-in-children-during-dental-rehabilitation-under-general-anaesthesia
#20
Dilek Günay Canpolat, Kenan Cantekin, Adnan Bayram, Mustafa Denizhan Yıldırım
Although the endotracheal tube (ETT) cuff may be associated with tracheal morbidity, cuffed tubes may reduce the aspiration risk in oral procedures. Dentists must use a mouth prop to facilitate oral visualization and to protect the oral soft tissues during dental rehabilitation under general anaesthesia (DRGA). The aim of this study was to evaluate the effect of mouth prop on endotracheal tube intracuff pressure in children during DRGA. Two-hundred and three ASA I-II patients, <18 years of age (mean: 5...
January 20, 2017: Journal of Clinical Monitoring and Computing
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