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https://www.readbyqxmd.com/read/28637416/mixed-micelles-as-nano-polymer-therapeutics-of-docetaxel-increased-in-vitro-cytotoxicity-and-decreased-in-vivo-toxicity
#1
Arehalli S Manjappa, Popat S Kumbhar, Prajakta S Khopade, Ajit B Patil, John I Disouza
Docetaxel (DTX) has been used to treat several types of cancers, but it has provided pharmaceutical challenges due to its poor water solubility and toxicities associated with the co-solvents (tween-80 and ethanol). Nanopolymer therapeutics can be engineered to deliver anticancer agent specifically to cancer cells, thereby leaving normal healthy cells unaffected by toxic drugs such as DTX. The objective of the present study was to synthesize the polyacrylic acid (PAA)-DTX conjugate (PAADC) and preparation of nanopolymer therapeutics such as PAADC/DSPE-mPEG2000 mixed micelles (PAADC-DP MMs)...
June 21, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28532250/design-and-evaluation-of-mpeg-pla-micelles-functionalized-with-drug-interactive-domains-as-improved-drug-carriers-for-docetaxel-delivery
#2
Dingqing Qi, Feirong Gong, Xin Teng, Mingming Ma, Huijing Wen, Weihao Yuan, Yi Cheng, Chong Lu
Polymeric micelles are very attractive drug delivery systems for hydrophobic agents, owing to their readily tailorable chemical structure and ease for scale-up preparation. However, the intrinsic poor stability of drug-loaded micelles presents one of the major challenges for most micellar systems in the translation to clinical applications. In this study, a simple, well-defined, and easy-to-scale up 9-Fluorenylmethoxycarbonyl (Fmoc) and tert-butoxycarbonyl (Boc) containing lysine dendronized mPEG-PLA (mPEG-PLA-Lys(FB)2) micellar formulation was designed and prepared for docetaxel (DTX) delivery, in an effort to improve the stability of the micelles, and its physicochemical properties, pharmacokinetics, and anti-tumor efficacy against SKOV-3 ovarian cancer were evaluated...
May 31, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28460444/simultaneous-sentinel-lymph-node-computed-tomography-and-locoregional-chemotherapy-for-lymph-node-metastasis-in-rabbit-using-an-iodine-docetaxel-emulsion
#3
Honsoul Kim, Eun-Ji Jang, Sang Kyum Kim, Woo Jin Hyung, Dong Kyu Choi, Soo-Jeong Lim, Joon Seok Lim
PURPOSE: A sentinel lymph node (SLN) tracer can gain multi-functionality by combining it with additional components. We developed a SLN tracer consisting of iodine and docetaxel and applied it as a theragnostic nanoparticle to simultaneously perform SLN computed tomography (CT) lymphography and locoregional chemotherapy of the draining lymphatic system. RESULTS: Docetaxel could be loaded in iodine emulsions at a drug-to-surfactant weight ratio as high as that in the drug formulation Taxotere®...
April 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28454334/taxotere-induced-elevated-expression-of-il8-in-carcinoma-associated-fibroblasts-of-breast-invasive-ductal-cancer
#4
Yingliang Li, Guohua Rong, Hua Kang
Breast cancer is the most common malignant tumor in women worldwide, and accounts for an estimated 29% of new cases and 15% of cancer-associated mortalities each year. Invasive ductal carcinoma represents 70-80% of all breast cancer cases, which are responsible for the majority of breast cancer fatalities. Though great progress has been made in understanding the tumorigenesis and development of breast cancer, problems surrounding treatment persist. It was previously reported that carcinoma-associated fibroblasts (CAFs) may be closely associated with chemotherapy resistance...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454303/expression-of-er%C3%AE-gene-in-breast-carcinoma-and-the-relevance-in-neoadjuvant-therapy
#5
Jing Chang, Jihong Liu, Huiying Li, Jing Li, Yanling Mu, Bin Feng
In the present study, we examined the expression of the estrogen receptor β (ERβ) gene in breast cancer and its relevance in neoadjuvant therapy. In total, 120 breast cancer patients who were hospitalized in the Departments of Breast Disease and Medical Oncology served as the subjects of this study. The subjects were diagnosed with breast cancer phase II to phase IIIA, as confirmed by aspiration biopsy and iconography. The patients were divided into two groups in a randomized control manner, with 60 patients in each group...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28451410/doceaqualip-in-a-patient-with-prostate-cancer-who-had-an-allergic-reaction-to-conventional-docetaxel-a-case-report
#6
Radheshyam Naik, Mujtaba A Khan
Docetaxel has been widely used in the treatment of several cancers, including adenocarcinoma of the prostate gland. As docetaxel is insoluble in water, it must be administered with polysorbate 80 and ethanol, which are known to cause hypersensitivity reactions. Premedication with corticosteroids and antihistamines is advocated prior to docetaxel administration; however, toxicities, occasionally fatal, have been reported, even with corticosteroid premedication. We herein report the case of a patient with adenocarcinoma of the prostate, with bone metastasis and an Eastern Cooperative Oncology Group performance status of <2, who developed an allergic reaction to conventional docetaxel (Taxotere), despite being premedicated with corticosteroids and antihistamines...
March 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28437753/p-gp-modulatory-acetyl-11-keto-%C3%AE-boswellic-acid-based-nanoemulsified-carrier-system-for-augmented-oral-chemotherapy-of-docetaxel
#7
Gitu Pandey, Naresh Mittapelly, Guru Raghavendra Valicherla, Ravi Prakash Shukla, Shweta Sharma, Venkatesh Teja Banala, Sandeep Urandur, Arun Kumar Jajoriya, Kalyan Mitra, D P Mishra, J R Gayen, P R Mishra
In spite of being a very potent and promising drug against many types of cancer, docetaxel suffers the disadvantage of low solubility and poor bioavailability rendering it unsuitable for oral administration. Also, the available marketed formulation for intravenous administration has its inherent drawbacks owing to the presence of polysorbate 80. Here, we exploited the anticancer and P-gp inhibitory potential of naturally occurring frankincense oil to fabricate a stable docetaxel loaded nanoemulsified carrier system for oral delivery...
April 15, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28415388/targeted-delivery-of-docetaxel-via-pi-pi-stacking-stabilized-dendritic-polymeric-micelles-for-enhanced-therapy-of-liver-cancer
#8
Xiaolong Tang, Shuping Zhou, Xinrong Tao, Jian Wang, Fangyu Wang, Yong Liang
Delivery of taxane-based chemotherapeutics including Docetaxel (DTX) by conventional polymeric micelles still suffers from insufficient stability and rapid premature release during the circulation, which limits their targeting and anticancer efficiency. To conquer these challenges, we developed a novel DTX-loaded Pi-Pi stacking-stabilized dendritic polymeric micelle for targeted therapy of liver cancer. This dendritic polymeric micelle, referred to DPM-DTX-cRGD, was self-assembled from DTX and biodegradable dendritic block copolymers Poly(amidoamine)-poly(γ-benzyl-l-Glutamate)-b-polyethylene glycol-cRGD (PAM-PBLG-b-PEG-cRGD)...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28359741/targeting-the-mercapturic-acid-pathway-and-vicenin-2-for-prevention-of-prostate-cancer
#9
REVIEW
Sharad S Singhal, Divya Jain, Preeti Singhal, Sanjay Awasthi, Jyotsana Singhal, David Horne
Prostate cancer (CaP) is often androgen-sensitive malignancy and regresses upon inhibition of androgen signaling. However, CaP, nearly always develops androgen resistance and progresses to aggressive and lethal androgen-independent CaP, which lacks satisfactory therapy. For metastatic CaP, patients are often treated with Taxotere (docetaxel), a cytoskeleton-targeted chemotherapy drug, that provides transient palliative benefit but to which patients rapidly develop drug-resistance. Combination chemotherapy may be used instead, but is more toxic and adds little clinically relevant benefit over docetaxel...
March 28, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28314341/navelbine%C3%A2-and-taxot%C3%A3-re%C3%A2-1st-edition
#10
(no author information available yet)
No abstract text is available yet for this article.
March 2017: Anticancer Research
https://www.readbyqxmd.com/read/28165821/successful-delivery-of-docetaxel-to-rat-brain-using-experimentally-developed-nanoliposome-a-treatment-strategy-for-brain-tumor
#11
Tapan Kumar Shaw, Dipika Mandal, Goutam Dey, Murari Mohan Pal, Paramita Paul, Samrat Chakraborty, Kazi Asraf Ali, Biswajit Mukherjee, Amal Kumar Bandyopadhyay, Mahitosh Mandal
Docetaxel (DTX) is found to be very effective against glioma cell in vitro. However, in vivo passage of DTX through BBB is extremely difficult due to the physicochemical and pharmacological characteristics of the drug. No existing formulation is successful in this aspect. Hence, in this study, effort was made to send DTX through blood-brain barrier (BBB) to brain to treat diseases such as solid tumor of brain (glioma) by developing DTX-loaded nanoliposomes. Primarily drug-excipients interaction was evaluated by FTIR spectroscopy...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28017889/blood-brain-barrier-penetrating-amphiphilic-polymer-nanoparticles-deliver-docetaxel-for-the-treatment-of-brain-metastases-of-triple-negative-breast-cancer
#12
Chunsheng He, Ping Cai, Jason Li, Tian Zhang, Lucy Lin, Azhar Z Abbasi, Jeffrey T Henderson, Andrew Michael Rauth, Xiao Yu Wu
Brain metastasis is a fatal disease with limited treatment options and very short survival. Although systemic chemotherapy has some effect on peripheral metastases of breast cancer, it is ineffective in treating brain metastasis due largely to the blood-brain barrier (BBB). Here we developed a BBB-penetrating amphiphilic polymer-lipid nanoparticle (NP) system that efficiently delivered anti-mitotic drug docetaxel (DTX) for the treatment of brain metastasis of triple negative breast cancer (TNBC). We evaluated the biodistribution, brain accumulation, pharmacokinetics and efficacy of DTX-NP in a mouse model of brain metastasis of TNBC...
December 23, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27997900/a-difference-in-the-incidences-of-hypersensitivity-reactions-to-original-and-generic-taxanes
#13
Tanchanok Ratanajarusiri, Virote Sriuranpong, Piyada Sitthideatphaiboon, Nattaya Poovoravan, Chanida Vinayanuwat, Napa Parinyanitikul, Pattama Angspatt, Wilai Thawinwisan, Suebpong Tanasanvimon
PURPOSE: To compare incidences of hypersensitivity reaction (HSR) between original and generic taxanes including paclitaxel and docetaxel. METHODS: We conducted a prospective study enrolling all patients receiving taxanes at King Chulalongkorn Memorial Hospital. Taxanes were infused accordingly to the step-wise rate escalation protocol at this hospital. Active surveillance for HSRs was performed. During the study period, there was only 1 generic brand used for each taxane...
2017: Chemotherapy
https://www.readbyqxmd.com/read/27991616/atb-0-transporter-mediated-targeting-delivery-to-human-lung-cancer-cells-via-aspartate-modified-docetaxel-loading-stealth-liposomes
#14
Qiuhua Luo, Bin Yang, Wenhui Tao, Jia Li, Longfa Kou, He Lian, Xin Che, Zhonggui He, Jin Sun
Tumor cells have an increased demand for amino acids to support their rapid growth and malignant metastasis. Transfer of amino acids across plasma membranes depends on several amino acid transporters that are highly upregulated in tumor cells and are promising targets for tumor cell-selective therapy. In this study, stealth liposomal systems functionalized with aspartate-polyoxyethylene stearate conjugate (APS) were developed for transporter-mediated targeted delivery to ATB(0,+), which is overexpressed human lung cells...
December 19, 2016: Biomaterials Science
https://www.readbyqxmd.com/read/27981366/a-prospective-exploration-of-symptom-burden-clusters-in-women-with-breast-cancer-during-chemotherapy-treatment
#15
Maria Browall, Yvonne Brandberg, Salmir Nasic, Per Rydberg, Jonas Bergh, Andreas Rydén, Hanjing Xie, Irene Eriksson, Yvonne Wengström
PURPOSE: The aim was to prospectively map symptom clusters in patients with stage I-IIIa breast cancer during standard chemotherapy treatment in a randomised study. METHODS: Participants completed the Memorial Symptom Assessment Scale (MSAS) at baseline, day 12 after the first and third cycle of FEC 75 or FEC 100, and day 12 after the last cycle of Taxotere. Cut-off values for symptom scores, a mean value based on each individual reporting a symptom including occurrence, frequency, severity and distress for inclusion in analysis, were determined...
May 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/27968861/effects-of-induction-taxotere-platinum-and-fluorouracil-tpf-chemotherapy-in-patients-with-stage-iii-and-iva-b-nasopharyngeal-cancer-treated-with-concurrent-chemoradiation-therapy-final-results-of-two-parallel-phase-2-clinical-trials
#16
Lin Kong, Youwang Zhang, Chaosu Hu, Ye Guo, Jiade J Lu
BACKGROUND: Concurrent chemoradiotherapy (CCRT) is the standard treatment for locally advanced nasopharyngeal cancer. The effect of induction chemotherapy plus CCRT in patients with this stage of disease is unclear. We therefore examined the long-term outcomes of the addition of induction chemotherapy (consisting of docetaxel, cisplatin, and fluorouracil [TPF]) to CCRT in patients with stage III and IVA/B nasopharyngeal cancer. METHODS: Between January, 2007, and July, 2011, we synchronously undertook two parallel phase 2 single-arm trials to evaluate the efficacy and toxicity of TPF-based induction chemotherapy...
October 2016: Lancet
https://www.readbyqxmd.com/read/27966988/docetaxel-loaded-plga-nanoparticles-improve-efficacy-in-taxane-resistant-triple-negative-breast-cancer
#17
Charles J Bowerman, James D Byrne, Kevin S Chu, Allison N Schorzman, Amanda W Keeler, Candice A Sherwood, Jillian L Perry, James C Luft, David B Darr, Allison M Deal, Mary E Napier, William C Zamboni, Norman E Sharpless, Charles M Perou, Joseph M DeSimone
Novel treatment strategies, including nanomedicine, are needed for improving management of triple-negative breast cancer. Patients with triple-negative breast cancer, when considered as a group, have a worse outcome after chemotherapy than patients with breast cancers of other subtypes, a finding that reflects the intrinsically adverse prognosis associated with the disease. The aim of this study was to improve the efficacy of docetaxel by incorporation into a novel nanoparticle platform for the treatment of taxane-resistant triple-negative breast cancer...
January 11, 2017: Nano Letters
https://www.readbyqxmd.com/read/27873118/current-update-of-a-carboxymethylcellulose-peg-conjugate-platform-for-delivery-of-insoluble-cytotoxic-agents-to-tumors
#18
Yang Yang, Joseph Bteich, Shyh-Dar Li
Cytotoxic chemotherapeutic agents are used as the standard therapy for a range of significant cancers, but many of these drugs suffer from poor water solubility and low selectivity, limiting their clinical efficacy. To overcome these shortcomings, Cellax™ drug delivery platform was developed. Cellax™ is a polymer-based nanoparticle drug delivery system designed to solubilize hydrophobic drugs and target them to solid tumors, thereby enhancing the efficacy and reducing the side effects. Cellax-docetaxel (Cellax-DTX) displayed improved pharmacokinetic, safety, and efficacy profiles compared to native DTX (Taxotere®) and Nab-paclitaxel (Nab-PTX, Abraxane®) in multiple animal models...
March 2017: AAPS Journal
https://www.readbyqxmd.com/read/27861147/arctigenin-inhibits-stat3-and-exhibits-anticancer-potential-in-human-triple-negative-breast-cancer-therapy
#19
Tingting Feng, Wei Cao, Wanxiang Shen, Liang Zhang, Xinsheng Gu, Yang Guo, Hsiang-I Tsai, Xuewen Liu, Jian Li, Jingxuan Zhang, Shan Li, Fuyun Wu, Ying Liu
Triple-negative breast cancers (TNBCs) are the most aggressive and hard-to-treat breast tumors with poor prognosis, and exploration for novel therapeutic drugs is impending. Arctigenin (Atn), a bioactive lignan isolated from seeds of Arctium lappa L, has been reported to inhibit many cancer types; however, the effect of Atn on TNBC remains unclear. In this study, we demonstrated that Atn decreased proliferation, and induced apoptosis in TNBC cells. Furthermore, we explored the underlying mechanism of Atn inhibition on TNBC cells...
January 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/27675824/the-effects-of-induction-taxotere-platinum-and-fluorouracil-tpf-chemotherapy-in-patients-with-stage-iii-and-iva-b-nasopharyngeal-cancer-treated-with-concurrent-chemoradiation-therapy-long-term-results-of-2-parallel-phase-2-clinical-trials
#20
L Kong, C Hu, Y Guo, Y Zhang, J J Lu
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
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