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https://www.readbyqxmd.com/read/29416331/pharmacokinetics-and-in-vitro-in-vivo-antitumor-efficacy-of-aptamer-targeted-ecoflex-%C3%A2-nanoparticles-for-docetaxel-delivery-in-ovarian-cancer
#1
Erfaneh Ghassami, Jaleh Varshosaz, Ali Jahanian-Najafabadi, Mohsen Minaiyan, Parvin Rajabi, Effat Hayati
Purpose: Epithelixal ovarian cancer is the fourth cause of cancer death in developed countries with 77% of ovarian cancer cases diagnosed with regional or distant metastasis, with poor survival rates. Docetaxel (DTX) is a well-known anticancer agent, with clinically proven efficacy in several malignancies, including ovarian cancer. However, the adverse effects caused by the active ingredient or currently marketed formulations could even deprive the patient of the advantages of treatment...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29352946/redox-enzyme-sensitive-chondroitin-sulfate-based-self-assembled-nanoparticles-loading-docetaxel-for-the-inhibition-of-metastasis-and-growth-of-melanoma
#2
Mengrui Liu, Hongliang Du, Abdur Rauf Khan, Jianbo Ji, Aihua Yu, Guangxi Zhai
In this report, redox/enzyme responsive chondroitin sulfate-ss-deoxycholic acid (CSCD) conjugates were synthesized using cystamine as the linkage which could self-assemble to form self-assembled nanoparticles (175.6 + 5.2 nm) in the aqueous environment. Docetaxel (DTX) was loaded in nanoparticles with desired loading efficiency for the inhibition of tumor growth and metastasis of melanoma. Interestingly, nanoparticles were demonstrated to respond to hyaluronidase-1 (Hyal-1) which could degrade chondroitin sulfate (CS) backbones...
March 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29288085/redox-responsive-polymeric-micelles-formed-by-conjugating-gambogic-acid-with-bioreducible-poly-amido-amine-s-for-the-co-delivery-of-docetaxel-and-mmp-9-shrna
#3
Yanan Kang, Lu Lu, Jinshuai Lan, Yue Ding, Jing Yang, Yong Zhang, Yuan Zhao, Tong Zhang, Rodney J Y Ho
A novel redox-sensitive system for co-delivering hydrophobic drugs and hydrophilic siRNA or shRNA was developed by conjugating gambogic acid (GA) with poly(amido amine)s (PAAs) through amide bonds, which is called GA-conjugated PAAs (PAG). PAG can self-assemble into micelles as amphiphilic block copolymers, which exhibits an excellent loading ability for the co-delivery of docetaxel (DTX) and MMP-9 shRNA with adjustable dosing ratios. In addition, confocal microscopy, flow cytometry and in vitro transfection analyses demonstrated more efficient cellular internalization of DTX and MMP-9 shRNA after incubation with PAG/DTX- MMP-9 shRNA micelles (PAG/DTX-shRNA) than with free drugs...
December 26, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29070988/anti-phosphohistone-h3-positive-mitoses-are-linked-to-pathological-response-in-neoadjuvantly-treated-breast-cancer
#4
Martin Sillem, Sylvia Timme, Peter Bronsert, Lioudmila Bogatyreva, Dieter Hauschke, Axel Zur Hausen, Martin Werner, Elmar Stickeler
BACKGROUND: We evaluated breast cancer (BC) core biopsies taken before neoadjuvant chemotherapy (NACT) by immunohistochemistry using anti-phosphohistone H3 (PHH3) antibody to determine mitosis, and correlated the results to clinicopathological data and histopathological regression of resected tumor specimens after NACT. METHODS: 72 patients with either triple-negative (TN) or luminal type BC received NACT with epirubicin/cyclophosphamide (EC) and Taxotere®. Tumor regression was analyzed in resected specimens; pathological complete response (pCR) was achieved in 22...
September 2017: Breast Care
https://www.readbyqxmd.com/read/28868260/tpoab-and-thyroid-function-are-not-associated-with-breast-cancer-outcome-evidence-from-a-large-scale-study-using-data-from-the-taxotere-as-adjuvant-chemotherapy-trial-tact-cruk01-001
#5
Ilaria Muller, Lucy S Kilburn, Peter N Taylor, Peter J Barrett-Lee, Judith M Bliss, Paul Ellis, Marian E Ludgate, Colin M Dayan
BACKGROUND: Small-scale studies correlated the presence of thyroid autoimmunity with both improved or worsened breast cancer outcome. OBJECTIVES: We aimed to clarify this association in a large cohort using the phase III, randomized, controlled Taxotere as Adjuvant Chemotherapy Trial (TACT, CRUK01/001). METHODS: TACT women >18 years old with node-positive or high-risk node-negative early breast cancer (pT1-3a, pN0-1, M0), with stored plasma (n = 1,974), taken 15...
July 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/28864856/comparison-of-adverse-events-following-injection-of-original-or-generic-docetaxel-for-the-treatment-of-breast-cancer
#6
Nao Tagawa, Erika Sugiyama, Masataka Tajima, Yasutsuna Sasaki, Seigo Nakamura, Hiromi Okuyama, Hisanori Shimizu, Vilasinee Hirunpanich Sato, Tadanori Sasaki, Hitoshi Sato
PURPOSE: The approval of injectable generic drugs does not require bioequivalence testing. However, although generic products contain the same level of the active compound, the levels and types of additives present can differ from those used in the original product. Since docetaxel is highly lipophilic, polysorbate 80 (PS80), polyethylene glycol (PEG), and ethyl alcohol are employed to solubilize this anticancer agent. This retrospective study compared the safety of five docetaxel products (Taxotere(®), Docetaxel Hospira, Docetaxel Sandoz, Docetaxel Sawai, and Docetaxel EE)...
October 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28678638/polysialic-acid-and-pluronic-f127-mixed-polymeric-micelles-of-docetaxel-as-new-approach-for-enhanced-antitumor-efficacy
#7
Ting Zhang, Songlei Zhou, Yang Liu, Xiang Luo, Donghua Di, Yanzhi Song, Xinrong Liu, Yihui Deng
In our previous study, polysialic acid-octadecyl dimethyl betaine (PSA-BS18) was synthesized and modified to liposomal EPI. Preliminary experiments revealed that the PSA-BS18 was a potential material for targeting tumor site with superior curative effects. In this study, PSA-BS18 and Pluronic F127 (F127) mixed polymeric micelles encapsulated docetaxel (DTX) (FP/DTX) were prepared by a self-assembly method. The FP/DTX was found to have a diameter of 34.83 ± 0.50 nm with a narrow polydispersity, the entrapment efficiency was 99...
November 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28637416/mixed-micelles-as-nano-polymer-therapeutics-of-docetaxel-increased-in-vitro-cytotoxicity-and-decreased-in-vivo-toxicity
#8
Arehalli S Manjappa, Popat S Kumbhar, Prajakta S Khopade, Ajit B Patil, John I Disouza
Docetaxel (DTX) has been used to treat several types of cancers, but it has provided pharmaceutical challenges due to its poor water solubility and toxicities associated with the co-solvents (tween-80 and ethanol). Nanopolymer therapeutics can be engineered to deliver anticancer agent specifically to cancer cells, thereby leaving normal healthy cells unaffected by toxic drugs such as DTX. The objective of the present study was to synthesize the polyacrylic acid (PAA)-DTX conjugate (PAADC) and preparation of nanopolymer therapeutics such as PAADC/DSPE-mPEG2000 mixed micelles (PAADC-DP MMs)...
June 21, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28532250/design-and-evaluation-of-mpeg-pla-micelles-functionalized-with-drug-interactive-domains-as-improved-drug-carriers-for-docetaxel-delivery
#9
Dingqing Qi, Feirong Gong, Xin Teng, Mingming Ma, Huijing Wen, Weihao Yuan, Yi Cheng, Chong Lu
Polymeric micelles are very attractive drug delivery systems for hydrophobic agents, owing to their readily tailorable chemical structure and ease for scale-up preparation. However, the intrinsic poor stability of drug-loaded micelles presents one of the major challenges for most micellar systems in the translation to clinical applications. In this study, a simple, well-defined, and easy-to-scale up 9-Fluorenylmethoxycarbonyl (Fmoc) and tert-butoxycarbonyl (Boc) containing lysine dendronized mPEG-PLA (mPEG-PLA-Lys(FB)2) micellar formulation was designed and prepared for docetaxel (DTX) delivery, in an effort to improve the stability of the micelles, and its physicochemical properties, pharmacokinetics, and anti-tumor efficacy against SKOV-3 ovarian cancer were evaluated...
May 31, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28460444/simultaneous-sentinel-lymph-node-computed-tomography-and-locoregional-chemotherapy-for-lymph-node-metastasis-in-rabbit-using-an-iodine-docetaxel-emulsion
#10
Honsoul Kim, Eun-Ji Jang, Sang Kyum Kim, Woo Jin Hyung, Dong Kyu Choi, Soo-Jeong Lim, Joon Seok Lim
PURPOSE: A sentinel lymph node (SLN) tracer can gain multi-functionality by combining it with additional components. We developed a SLN tracer consisting of iodine and docetaxel and applied it as a theragnostic nanoparticle to simultaneously perform SLN computed tomography (CT) lymphography and locoregional chemotherapy of the draining lymphatic system. RESULTS: Docetaxel could be loaded in iodine emulsions at a drug-to-surfactant weight ratio as high as that in the drug formulation Taxotere®...
April 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28454334/taxotere-induced-elevated-expression-of-il8-in-carcinoma-associated-fibroblasts-of-breast-invasive-ductal-cancer
#11
Yingliang Li, Guohua Rong, Hua Kang
Breast cancer is the most common malignant tumor in women worldwide, and accounts for an estimated 29% of new cases and 15% of cancer-associated mortalities each year. Invasive ductal carcinoma represents 70-80% of all breast cancer cases, which are responsible for the majority of breast cancer fatalities. Though great progress has been made in understanding the tumorigenesis and development of breast cancer, problems surrounding treatment persist. It was previously reported that carcinoma-associated fibroblasts (CAFs) may be closely associated with chemotherapy resistance...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454303/expression-of-er%C3%AE-gene-in-breast-carcinoma-and-the-relevance-in-neoadjuvant-therapy
#12
Jing Chang, Jihong Liu, Huiying Li, Jing Li, Yanling Mu, Bin Feng
In the present study, we examined the expression of the estrogen receptor β (ERβ) gene in breast cancer and its relevance in neoadjuvant therapy. In total, 120 breast cancer patients who were hospitalized in the Departments of Breast Disease and Medical Oncology served as the subjects of this study. The subjects were diagnosed with breast cancer phase II to phase IIIA, as confirmed by aspiration biopsy and iconography. The patients were divided into two groups in a randomized control manner, with 60 patients in each group...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28451410/doceaqualip-in-a-patient-with-prostate-cancer-who-had-an-allergic-reaction-to-conventional-docetaxel-a-case-report
#13
Radheshyam Naik, Mujtaba A Khan
Docetaxel has been widely used in the treatment of several cancers, including adenocarcinoma of the prostate gland. As docetaxel is insoluble in water, it must be administered with polysorbate 80 and ethanol, which are known to cause hypersensitivity reactions. Premedication with corticosteroids and antihistamines is advocated prior to docetaxel administration; however, toxicities, occasionally fatal, have been reported, even with corticosteroid premedication. We herein report the case of a patient with adenocarcinoma of the prostate, with bone metastasis and an Eastern Cooperative Oncology Group performance status of <2, who developed an allergic reaction to conventional docetaxel (Taxotere), despite being premedicated with corticosteroids and antihistamines...
March 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28437753/p-gp-modulatory-acetyl-11-keto-%C3%AE-boswellic-acid-based-nanoemulsified-carrier-system-for-augmented-oral-chemotherapy-of-docetaxel
#14
Gitu Pandey, Naresh Mittapelly, Guru Raghavendra Valicherla, Ravi Prakash Shukla, Shweta Sharma, Venkatesh Teja Banala, Sandeep Urandur, Arun Kumar Jajoriya, Kalyan Mitra, D P Mishra, J R Gayen, P R Mishra
In spite of being a very potent and promising drug against many types of cancer, docetaxel suffers the disadvantage of low solubility and poor bioavailability rendering it unsuitable for oral administration. Also, the available marketed formulation for intravenous administration has its inherent drawbacks owing to the presence of polysorbate 80. Here, we exploited the anticancer and P-gp inhibitory potential of naturally occurring frankincense oil to fabricate a stable docetaxel loaded nanoemulsified carrier system for oral delivery...
April 15, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28415388/targeted-delivery-of-docetaxel-via-pi-pi-stacking-stabilized-dendritic-polymeric-micelles-for-enhanced-therapy-of-liver-cancer
#15
Xiaolong Tang, Shuping Zhou, Xinrong Tao, Jian Wang, Fangyu Wang, Yong Liang
Delivery of taxane-based chemotherapeutics including Docetaxel (DTX) by conventional polymeric micelles still suffers from insufficient stability and rapid premature release during the circulation, which limits their targeting and anticancer efficiency. To conquer these challenges, we developed a novel DTX-loaded Pi-Pi stacking-stabilized dendritic polymeric micelle for targeted therapy of liver cancer. This dendritic polymeric micelle, referred to DPM-DTX-cRGD, was self-assembled from DTX and biodegradable dendritic block copolymers Poly(amidoamine)-poly(γ-benzyl-l-Glutamate)-b-polyethylene glycol-cRGD (PAM-PBLG-b-PEG-cRGD)...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28359741/targeting-the-mercapturic-acid-pathway-and-vicenin-2-for-prevention-of-prostate-cancer
#16
REVIEW
Sharad S Singhal, Divya Jain, Preeti Singhal, Sanjay Awasthi, Jyotsana Singhal, David Horne
Prostate cancer (CaP) is often androgen-sensitive malignancy and regresses upon inhibition of androgen signaling. However, CaP, nearly always develops androgen resistance and progresses to aggressive and lethal androgen-independent CaP, which lacks satisfactory therapy. For metastatic CaP, patients are often treated with Taxotere (docetaxel), a cytoskeleton-targeted chemotherapy drug, that provides transient palliative benefit but to which patients rapidly develop drug-resistance. Combination chemotherapy may be used instead, but is more toxic and adds little clinically relevant benefit over docetaxel...
August 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28314341/navelbine%C3%A2-and-taxot%C3%A3-re%C3%A2-1st-edition
#17
(no author information available yet)
No abstract text is available yet for this article.
March 2017: Anticancer Research
https://www.readbyqxmd.com/read/28165821/successful-delivery-of-docetaxel-to-rat-brain-using-experimentally-developed-nanoliposome-a-treatment-strategy-for-brain-tumor
#18
Tapan Kumar Shaw, Dipika Mandal, Goutam Dey, Murari Mohan Pal, Paramita Paul, Samrat Chakraborty, Kazi Asraf Ali, Biswajit Mukherjee, Amal Kumar Bandyopadhyay, Mahitosh Mandal
Docetaxel (DTX) is found to be very effective against glioma cell in vitro. However, in vivo passage of DTX through BBB is extremely difficult due to the physicochemical and pharmacological characteristics of the drug. No existing formulation is successful in this aspect. Hence, in this study, effort was made to send DTX through blood-brain barrier (BBB) to brain to treat diseases such as solid tumor of brain (glioma) by developing DTX-loaded nanoliposomes. Primarily drug-excipients interaction was evaluated by FTIR spectroscopy...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28017889/blood-brain-barrier-penetrating-amphiphilic-polymer-nanoparticles-deliver-docetaxel-for-the-treatment-of-brain-metastases-of-triple-negative-breast-cancer
#19
Chunsheng He, Ping Cai, Jason Li, Tian Zhang, Lucy Lin, Azhar Z Abbasi, Jeffrey T Henderson, Andrew Michael Rauth, Xiao Yu Wu
Brain metastasis is a fatal disease with limited treatment options and very short survival. Although systemic chemotherapy has some effect on peripheral metastases of breast cancer, it is ineffective in treating brain metastasis due largely to the blood-brain barrier (BBB). Here we developed a BBB-penetrating amphiphilic polymer-lipid nanoparticle (NP) system that efficiently delivered anti-mitotic drug docetaxel (DTX) for the treatment of brain metastasis of triple negative breast cancer (TNBC). We evaluated the biodistribution, brain accumulation, pharmacokinetics and efficacy of DTX-NP in a mouse model of brain metastasis of TNBC...
December 23, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27997900/a-difference-in-the-incidences-of-hypersensitivity-reactions-to-original-and-generic-taxanes
#20
Tanchanok Ratanajarusiri, Virote Sriuranpong, Piyada Sitthideatphaiboon, Nattaya Poovoravan, Chanida Vinayanuwat, Napa Parinyanitikul, Pattama Angspatt, Wilai Thawinwisan, Suebpong Tanasanvimon
PURPOSE: To compare incidences of hypersensitivity reaction (HSR) between original and generic taxanes including paclitaxel and docetaxel. METHODS: We conducted a prospective study enrolling all patients receiving taxanes at King Chulalongkorn Memorial Hospital. Taxanes were infused accordingly to the step-wise rate escalation protocol at this hospital. Active surveillance for HSRs was performed. During the study period, there was only 1 generic brand used for each taxane...
2017: Chemotherapy
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