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https://www.readbyqxmd.com/read/28437860/chronic-inhibition-of-fatty-acid-amide-hydrolase-by-urb597-produces-differential-effects-on-cardiac-performance-in-normotensive-and-hypertensive-rats
#1
Anna Pedzinska-Betiuk, Jolanta Weresa, Marek Toczek, Marta Baranowska-Kuczko, Irena Kasacka, Ewa Harasim-Symbor, Barbara Malinowska
BACKGROUND AND PURPOSE: Fatty acid amide hydrolase (FAAH) inhibitors are postulated to possess anti-hypertensive potential, because their acute injection decreases blood pressure (BP) in spontaneously hypertensive rats (SHR) partially through normalization of cardiac contractile function. Here, we examined whether the potential hypotensive effect of chronic FAAH inhibition by URB597 in hypertensive rats correlates with changes in cardiac performance. EXPERIMENTAL APPROACH: Experiments were performed using perfused hearts and left atria isolated from 8-10 week old SHR, age-matched deoxycorticosterone acetate (DOCA-salt) rats and normotensive controls chronically treated with URB597 (1 mg kg(-1) ) or vehicle...
April 24, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28437757/abnormal-loading-and-functional-deficits-are-present-in-both-limbs-before-and-after-unilateral-knee-arthroplasty
#2
A J Metcalfe, C J Stewart, N J Postans, P R Biggs, G M Whatling, C A Holt, A P Roberts
Unilateral knee replacement is often followed by a contralateral replacement in time and the biomechanics of the other knee before and after knee replacement remains poorly understood. The aim of this paper is to distinguish the features of arthritic gait in the affected and unaffected legs relative to a normal population and to assess the objective recovery of gait function post-operatively, with the aim of defining patients at risk of poor post-operative function. Twenty patients with severe knee OA but no pain or deformity in any other lower limb joint were compared to twenty healthy subjects of the same age...
April 4, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28437631/age-independent-anti-m%C3%A3-llerian-hormone-amh-standard-deviation-scores-to-estimate-ovarian-function
#3
Josef van Helden, Ralf Weiskirchen
OBJECTIVIES: To determine single year age-specific anti-Müllerian hormone (AMH) standard deviation scores (SDS) for women associated to normal ovarian function and different ovarian disorders resulting in sub- or infertility. DESIGN AND METHODS: Determination of particular year median and mean AMH values with standard deviations (SD), calculation of age-independent cut off SDS for the discrimination between normal ovarian function and ovarian disorders. RESULTS: Single-year-specific median, mean, and SD values have been evaluated for the Beckman Access AMH immunoassay...
April 18, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28437601/maternal-hemodynamics-in-normal-pregnancies-reference-ranges-and-the-role-of-maternal-characteristics
#4
Dimuthu Vinayagam, Baskaran Thilaganathan, Oliver Stirrup, Elena Mantovani, Asma Khalil
OBJECTIVES: The main aim of this study was to construct reference ranges of the maternal central hemodynamic parameters during pregnancy. The second aim was to determine the maternal and pregnancy characteristics, which influence these hemodynamic parameters. METHODS: This was a prospective cohort study of low-risk pregnant women attending for routine antenatal care at St George's Hospital, London. The exclusion criteria included any medical disorder present at the time of study recruitment, or development of hypertension or intrauterine fetal growth restriction following study recruitment...
April 24, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28437567/people-with-patellofemoral-oa-walk-with-different-pelvic-and-hip-kinematics-compared-to-healthy-aged-matched-controls
#5
Kay M Crossley, Anthony G Schache, Hannah Ozturk, Jonathan Lentzos, Melissa Munanto, Marcus G Pandy
Objective, Patellofemoral joint (PFJ) osteoarthritis (OA) is common, yet little is known about how this condition influences lower-limb biomechanical function. This study compared pelvis and lower-limb kinematics in people with and without PFJOA., Methods, Sixty-nine participants (64% women, mean age 56±10 years) with anterior knee pain aggravated by PFJ loaded activities (stair ambulation, rising from sitting, squatting) and radiographic lateral PFJOA on skyline radiographs were compared with 18 controls (78% women, mean age 53±7 years) with no lower-limb pain or radiographic OA...
April 24, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28437538/effects-of-diagnosis-by-newborn-screening-for-cystic-fibrosis-on-weight-and-length-in-the-first-year-of-life
#6
Daniel H Leung, Sonya L Heltshe, Drucy Borowitz, Daniel Gelfond, Margaret Kloster, James E Heubi, Michael Stalvey, Bonnie W Ramsey
Importance: Since the implementation of universal newborn screening (NBS) for cystic fibrosis (CF), the timing and magnitude of growth deficiency or its association with correlates of disease among infants with CF who underwent NBS has not been well described. Objective: To examine incremental weight gain, linear growth, and clinical features in the first year of life among infants with CF who underwent NBS. Design, Setting, and Participants: The Baby Observational and Nutrition Study (BONUS), a multicenter, longitudinal, observational cohort study, was conducted during regular CF clinic visits in the first 12 months of life at 28 US Cystic Fibrosis Foundation-accredited Care Centers from January 7, 2012, through May 31, 2015...
April 24, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28437344/comparison-of-the-posterior-vertebral-column-resection-with-the-expandable-cage-versus-the-nonexpandable-cage-in-thoracolumbar-angular-kyphosis
#7
Jung-Hee Lee, Hyun-Seok Oh, Jeong-Gyu Choi
STUDY DESIGN: This was a retrospective study. OBJECTIVE: To compare the radiographic and clinical results of anterior support with nonexpandable cage with those of expandable cage. SUMMARY OF BACKGROUND DATA: The goals of surgical treatment in patients with thoracolumbar angular kyphosis are to improve the neurological deficit through neural decompression, to restore the normal alignment by correction of deformity, and to stabilize the spinal column by arthrodesis...
May 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28437332/ultrasound-assessment-of-the-abdominal-muscles-at-rest-and-during-the-aslr-test-among-adolescents-with-scoliosis
#8
Paweł Linek, Edward Saulicz, Michał Kuszewski, Tomasz Wolny
STUDY DESIGN: Observational study. OBJECTIVE: Are there deviations in the thickness of abdominal muscles at rest in individuals with adolescent idiopathic scoliosis (AIS)? Are there deviations in abdominal muscular activity in people with AIS during the active straight leg raise (ASLR) test? SUMMARY OF BACKGROUND DATA: Ultrasound imaging can be used to assess the lateral abdominal muscle. Some authors suggest that scoliosis develops through a weakness or improper functioning of the abdominal muscles that cannot provide adequate support to the spinal segments...
May 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28437325/presenting-features-and-prognosis-of-ischemic-and-nonischemic-neonatal-liver-failure
#9
Carlos Zozaya Nieto, Beatriz Fernández Caamaño, Gema Muñoz Bartolo, Juan J Menéndez Suso, Esteban Frauca Remacha, Eva Valverde Núñez
OBJECTIVES: To describe the epidemiological features, clinical characteristics and outcomes of neonates diagnosed with liver failure, as well as determine prognostic factors. METHODS: Cohort study conducted at a single tertiary referral and university-affiliated pediatric center. Hospital records of all neonates diagnosed with liver failure between January 2003 and December 2015 were retrospectively reviewed, and data on clinical and laboratory findings, treatment, and outcomes were collected...
May 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28437284/a-retrospective-study-on-mycophenolic-acid-drug-interactions-effect-of-prednisone-sirolimus-and-tacrolimus-with-mpa
#10
Ana Catalina Alvarez-Elías, Elisa Catherine Yoo, Ekaterina Kirilova Todorova, Ram Nivas Singh, Guido Filler
Mycophenolic acid (MPA), the active compound of mycophenolate mofetil (MMF), is widely used as an antirejection drug following renal transplantation. There is growing evidence supporting the notion that there is substantial variability in the intra- and inter-patient exposure to MPA. Drug interactions involving MPA with tacrolimus, steroids, and sirolimus have been understudied. The objective of this study was to determine the relationship between MPA, steroids, tacrolimus, and sirolimus. MPA trough concentrations from 37 pediatric renal transplant recipients (mean age 7...
April 6, 2017: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/28437273/assessing-sensorineural-hearing-loss-using-various-transient-evoked-otoacoustic-emission-stimulus-conditions
#11
Daniel B Putterman, Douglas H Keefe, Lisa L Hunter, Angela C Garinis, Denis F Fitzpatrick, Garnett P McMillan, M Patrick Feeney
OBJECTIVES: An important clinical application of transient-evoked otoacoustic emissions (TEOAEs) is to evaluate cochlear outer hair cell function for the purpose of detecting sensorineural hearing loss (SNHL). Double-evoked TEOAEs were measured using a chirp stimulus, in which the stimuli had an extended frequency range compared to clinical tests. The present study compared TEOAEs recorded using an unweighted stimulus presented at either ambient pressure or tympanometric peak pressure (TPP) in the ear canal and TEOAEs recorded using a power-weighted stimulus at ambient pressure...
April 21, 2017: Ear and Hearing
https://www.readbyqxmd.com/read/28437250/ionizing-radiation-reduces-adam10-expression-in-brain-microvascular-endothelial-cells-undergoing-stress-induced-senescence
#12
Lucinda S McRobb, Matthew J McKay, Jennifer R Gamble, Michael Grace, Vaughan Moutrie, Estevam D Santos, Vivienne S Lee, Zhenjun Zhao, Mark P Molloy, Marcus A Stoodley
Cellular senescence is associated with aging and is considered a potential contributor to age-associated neurodegenerative disease. Exposure to ionizing radiation increases the risk of developing premature neurovascular degeneration and dementia but also induces premature senescence. As cells of the cerebrovascular endothelium are particularly susceptible to radiation and play an important role in brain homeostasis, we investigated radiation-induced senescence in brain microvascular endothelial cells (EC). Using biotinylation to label surface proteins, streptavidin enrichment and proteomic analysis, we analyzed the surface proteome of stress-induced senescent EC in culture...
April 17, 2017: Aging
https://www.readbyqxmd.com/read/28437198/branched-chain-amino-acids-are-associated-with-insulin-resistance-independent-of-leptin-and-adiponectin-in-subjects-with-varying-degrees-of-glucose-tolerance
#13
Margery A Connelly, Justyna Wolak-Dinsmore, Robin P F Dullaart
BACKGROUND: Branched chain amino acids (BCAA) may be involved in the pathogenesis of insulin resistance and are associated with type 2 diabetes mellitus (T2DM) development. Adipokines such as leptin and adiponectin influence insulin resistance and reflect adipocyte dysfunction. We examined the extent to which the association of BCAA with insulin resistance is attributable to altered leptin and adiponectin levels in individuals with varying degrees of glucose tolerance. METHODS: BCAA were measured by nuclear magnetic resonance, whereas leptin and adiponectin were measured by immunoassay, in subjects with normal fasting glucose (n = 30), impaired fasting glucose (n = 25), and T2DM (n = 15)...
February 21, 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28437035/the-association-between-oral-examination-findings-and-the-computed-tomographic-appearance-of-the-equine-temporomandibular-joint
#14
J L Carmalt, H Simhofer, A Bienert-Zeit, J E Rawlinson, C L Waldner
BACKGROUND: The temporomandibular joint (TMJ) forms the junction between the maxilla and mandible. Movement of the jaw and resulting masticatory forces have been extensively studied in the horse; however, less is known about the inter-relationship between this joint and oral and dental pathology. OBJECTIVES: To determine the association between specific oral and dental pathologies and anatomical variations of the TMJ imaged with computed tomography (CT) in horses with asymptomatic TMJs...
April 24, 2017: Equine Veterinary Journal
https://www.readbyqxmd.com/read/28437013/the-prognostic-value-of-b7-h6-protein-expression-in-human-oral-squamous-cell-carcinoma
#15
Jiongke Wang, Xin Jin, Jiajia Liu, Kui Zhao, Hao Xu, Jing Wen, Lu Jiang, Xin Zeng, Jing Li, Qianming Chen
OBJECTIVES: To investigate the expression and prognostic value of B7-H6 protein in oral squamous cell carcinoma tissues. MATERIALS AND METHODS: A total of 50 oral squamous cell carcinoma samples, 10 oral leukoplakia samples and 17 normal controls were included in the analysis. The expression of B7-H6 in oral squamous cell carcinoma, oral leukoplakia and normal controls was evaluated by immunohistochemical assay. RESULTS: The B7-H6 protein expression was significantly higher in oral squamous cell carcinoma tissues than that in normal oral mucosa...
April 24, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28436815/moyamoya-in-a-patient-with-fires-a-first-case-report
#16
Taylor Kaufman, Andrew White
Febrile infection-related epilepsy syndrome (FIRES) is a form of epileptic encephalopathy with severe refractory epilepsy that presents in previously healthy, school-aged children after significant febrile illness with concomitant rise in body temperature. Suspected causes include genetic or acquired channelopathies, as well as mitochondrial disturbances. In FIRES, the EEG shows diffuse slowing, generalized, and/or multifocal discharges. Seizures are present and resistant to treatment. Moyamoya angiopathy (MMA) is characterized by progressive stenosis of cerebral arteries and subsequent development of a network of collateral circulation that is prone to rupture...
2017: Neurodiagnostic Journal
https://www.readbyqxmd.com/read/28436726/impact-of-physical-activity-on-the-association-of-overweight-and-obesity-with-cardiovascular-disease-the-rotterdam-study
#17
Chantal M Koolhaas, Klodian Dhana, Josje D Schoufour, M Arfan Ikram, Maryam Kavousi, Oscar H Franco
Background Being overweight or obese is associated with an increased risk of cardiovascular disease (CVD). Physical activity might reduce the risk associated with overweight and obesity. We examined the association between overweight and obesity and CVD risk as a function of physical activity levels in a middle-aged and elderly population. Design The study was a prospective cohort study. Methods The study included 5344 participants aged 55 years or older from the population-based Rotterdam Study. Participants were classified as having high or low physical activity based on the median of the population...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28436697/liver-track-embolization-after-islet-cell-transplant-comparison-of-two-techniques
#18
Ron C Gaba, Kenji R Kobayashi, James T Bui, R Peter Lokken, Andrew J Lipnik, Charles E Ray, Jose Oberholzer
OBJECTIVE: The purpose of this study was to compare the efficacy and safety of microfibrillar collagen paste with those of gelatin sponge for liver track embolization after islet cell transplants. MATERIALS AND METHODS: In a single-institution, retrospective study, 37 patients underwent 66 islet cell transplants from January 2005 through October 2015. Transplants were performed with 6-French transhepatic access, systemic anticoagulation, pretransplant and posttransplant portal venous pressure measurement, and image-guided liver track embolization with gelatin sponge (2005-2011) or microfibrillar collagen paste (2012-2015)...
May 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28436540/early-diagnosis-of-bladder-exstrophy-quantitative-assessment-of-a-low-inserted-umbilical-cord
#19
Michal Fishel-Bartal, Sharon Perlman, Baruch Messing, Ron Bardin, Zvi Kivilevitch, Reuven Achiron, Yinon Gilboa
OBJECTIVES: Bladder exstrophy is a rare severe congenital malformation. Early prenatal diagnosis is scarcely described in the literature. Low insertion of the umbilical cord is a constant anatomic feature of bladder exstrophy. The aim of our study was to assess whether early measurements of the umbilical cord insertion-to-genital tubercle length may serve as quantitative measurements for a low-inserted umbilical cord in cases of bladder exstrophy. METHODS: The umbilical cord insertion-to-genital tubercle length was prospectively measured in all cases referred for a nonvisualized urinary bladder before 18 weeks' gestation...
April 24, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28436207/racial-differences-in-the-association-between-heart-rate-variability-and-left-ventricular-mass
#20
LaBarron K Hill, Lana L Watkins, Alan L Hinderliter, James A Blumenthal, Andrew Sherwood
PURPOSE: Increased left ventricular mass (LVM) is an early precursor of target organ damage due to hypertension. Diminished parasympathetic cardiac control has been linked to both hypertension onset and left ventricular impairment; however, emerging evidence suggests that this pattern may be different in African Americans. The present study sought to determine if race impacts the relationship between parasympathetic cardiac control and LVM. METHODS: LVM was assessed via echocardiography in a sample (N = 148) of African American and White adults (Mean age = 33...
April 24, 2017: Experimental Physiology
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