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Fast-spiking interneuron

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https://www.readbyqxmd.com/read/29214635/kv4-2-channel-activity-controls-intrinsic-firing-dynamics-of-arcuate-kisspeptin-neurons
#1
Philipe R F Mendonça, Victoria Kyle, Shel-Hwa Yeo, William H Colledge, Hugh P C Robinson
Kisspeptin neurons in the hypothalamus are critically involved in reproductive function, via their effect on GnRH neuron activity and consequent gonadotropin release. Kisspeptin neurons show an intrinsic irregularity of firing, but the mechanism of this remains unclear. To address this, we carried out targeted whole-cell patch-clamp recordings of kisspeptin neurons in the arcuate nucleus (Kiss1Arc ), in brain slices isolated from adult male Kiss-Cre:tdTomato mice. Cells fired irregularly in response to constant current stimuli, with a wide range of spike time variability, and prominent subthreshold voltage fluctuations...
December 6, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/29206101/serotonin-enhances-excitability-and-gamma-frequency-temporal-integration-in-mouse-prefrontal-fast-spiking-interneurons
#2
Jegath C Athilingam, Roy Ben-Shalom, Caroline M Keeshen, Vikaas Sohal, Kevin Bender
The medial prefrontal cortex plays a key role in higher order cognitive functions like decision making and social cognition. These complex behaviors emerge from the coordinated firing of prefrontal neurons. Fast-spiking interneurons (FSIs) control the timing of excitatory neuron firing via somatic inhibition and generate gamma (30-100 Hz) oscillations. Therefore, factors that regulate how FSIs respond to gamma-frequency input could affect both prefrontal circuit activity and behavior. Here, we show that serotonin (5HT), which is known to regulate gamma power, acts via 5HT2A receptors to suppress an inward-rectifying potassium conductance in FSIs...
December 5, 2017: ELife
https://www.readbyqxmd.com/read/29166601/triple-function-of-synaptotagmin-7-ensures-efficiency-of-high-frequency-transmission-at-central-gabaergic-synapses
#3
Chong Chen, Rachel Satterfield, Samuel M Young, Peter Jonas
Synaptotagmin 7 (Syt7) is thought to be a Ca(2+) sensor that mediates asynchronous transmitter release and facilitation at synapses. However, Syt7 is strongly expressed in fast-spiking, parvalbumin-expressing GABAergic interneurons, and the output synapses of these neurons produce only minimal asynchronous release and show depression rather than facilitation. To resolve this apparent contradiction, we examined the effects of genetic elimination of Syt7 on synaptic transmission at the GABAergic basket cell (BC)-Purkinje cell (PC) synapse in cerebellum...
November 21, 2017: Cell Reports
https://www.readbyqxmd.com/read/29149606/chronic-stress-alters-striosome-circuit-dynamics-leading-to-aberrant-decision-making
#4
Alexander Friedman, Daigo Homma, Bernard Bloem, Leif G Gibb, Ken-Ichi Amemori, Dan Hu, Sebastien Delcasso, Timothy F Truong, Joyce Yang, Adam S Hood, Katrina A Mikofalvy, Dirk W Beck, Norah Nguyen, Erik D Nelson, Sebastian E Toro Arana, Ruth H Vorder Bruegge, Ki A Goosens, Ann M Graybiel
Effective evaluation of costs and benefits is a core survival capacity that in humans is considered as optimal, "rational" decision-making. This capacity is vulnerable in neuropsychiatric disorders and in the aftermath of chronic stress, in which aberrant choices and high-risk behaviors occur. We report that chronic stress exposure in rodents produces abnormal evaluation of costs and benefits resembling non-optimal decision-making in which choices of high-cost/high-reward options are sharply increased...
November 16, 2017: Cell
https://www.readbyqxmd.com/read/29140973/a-coupled-oscillator-model-of-olfactory-bulb-gamma-oscillations
#5
Guoshi Li, Thomas A Cleland
The olfactory bulb transforms not only the information content of the primary sensory representation, but also its underlying coding metric. High-variance, slow-timescale primary odor representations are transformed by bulbar circuitry into secondary representations based on principal neuron spike patterns that are tightly regulated in time. This emergent fast timescale for signaling is reflected in gamma-band local field potentials, presumably serving to efficiently integrate olfactory sensory information into the temporally regulated information networks of the central nervous system...
November 15, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/29126935/age-dependent-and-region-specific-alteration-of-parvalbumin-neurons-and-perineuronal-nets-in-the-mouse-cerebral-cortex
#6
Hiroshi Ueno, Keizo Takao, Shunsuke Suemitsu, Shinji Murakami, Naoya Kitamura, Kenta Wani, Motoi Okamoto, Shozo Aoki, Takeshi Ishihara
Cognitive function declines with age. Such function depends on γ-oscillation in the frontal cortex. Pyramidal neurons, and the parvalbumin-expressing interneurons (PV neurons) that control them, are important for the generation of γ-oscillation. The mechanism by which cognitive function declines is unclear. Perineuronal nets (PNNs) mainly surround the soma and proximal dendrites and axon segments of PV neurons in the cerebral cortex. Previous evidence indicates that PNNs inhibit neural plasticity. If this is true, an increase in the number of neurons surrounded by PNNs or in the thickness or density of the PNNs around neurons could decrease plasticity in the cortex...
November 7, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/29101523/functional-comparison-of-corticostriatal-and-thalamostriatal-postsynaptic-responses-in-striatal-neurons-of-the-mouse
#7
M A Arias-García, D Tapia, J A Laville, V M Calderón, Y Ramiro-Cortés, J Bargas, E Galarraga
Synaptic inputs from cortex and thalamus were compared in electrophysiologically defined striatal cell classes: direct and indirect pathways' striatal projection neurons (dSPNs and iSPNs), fast-spiking interneurons (FS), cholinergic interneurons (ChINs), and low-threshold spiking-like (LTS-like) interneurons. Our purpose was to observe whether stimulus from cortex or thalamus had equivalent synaptic strength to evoke prolonged suprathreshold synaptic responses in these neuron classes. Subthreshold responses showed that inputs from either source functionally mix up in their dendrites at similar electrotonic distances from their somata...
November 3, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/29081006/callosal-responses-in-a-retrosplenial-column
#8
Alejandro Sempere-Ferràndez, Belén Andrés-Bayón, Emilio Geijo-Barrientos
The axons forming the corpus callosum sustain the interhemispheric communication across homotopic cortical areas. We have studied how neurons throughout the columnar extension of the retrosplenial cortex integrate the contralateral input from callosal projecting neurons in cortical slices. Our results show that pyramidal neurons in layers 2/3 and the large, thick-tufted pyramidal neurons in layer 5B showed larger excitatory callosal responses than layer 5A and layer 5B thin-tufted pyramidal neurons, while layer 6 remained silent to this input...
October 28, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/29067129/dynamical-responses-to-external-stimuli-for-both-cases-of-excitatory-and-inhibitory-synchronization-in-a-complex-neuronal-network
#9
Sang-Yoon Kim, Woochang Lim
For studying how dynamical responses to external stimuli depend on the synaptic-coupling type, we consider two types of excitatory and inhibitory synchronization (i.e., synchronization via synaptic excitation and inhibition) in complex small-world networks of excitatory regular spiking (RS) pyramidal neurons and inhibitory fast spiking (FS) interneurons. For both cases of excitatory and inhibitory synchronization, effects of synaptic couplings on dynamical responses to external time-periodic stimuli S(t) (applied to a fraction of neurons) are investigated by varying the driving amplitude A of S(t)...
October 2017: Cognitive Neurodynamics
https://www.readbyqxmd.com/read/29050390/involvement-of-fast-spiking-cells-in-ictal-sequences-during-spontaneous-seizures-in-rats-with-chronic-temporal-lobe-epilepsy
#10
Adam R Neumann, Robrecht Raedt, Hendrik W Steenland, Mathieu Sprengers, Katarzyna Bzymek, Zaneta Navratilova, Lilia Mesina, Jeanne Xie, Valerie Lapointe, Fabian Kloosterman, Kristl Vonck, Paul A J M Boon, Ivan Soltesz, Bruce L McNaughton, Artur Luczak
See Lenck-Santini (doi:10.1093/awx205) for a scientific commentary on this article. Epileptic seizures represent altered neuronal network dynamics, but the temporal evolution and cellular substrates of the neuronal activity patterns associated with spontaneous seizures are not fully understood. We used simultaneous recordings from multiple neurons in the hippocampus and neocortex of rats with chronic temporal lobe epilepsy to demonstrate that subsets of cells discharge in a highly stereotypical sequential pattern during ictal events, and that these stereotypical patterns were reproducible across consecutive seizures...
September 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29038238/delayed-maturation-of-fast-spiking-interneurons-is-rectified-by-activation-of-the-trkb-receptor-in-the-mouse-model-of-fragile-x-syndrome
#11
Toshihiro Nomura, Timothy F Musial, John J Marshall, Yiwen Zhu, Christine L Remmers, Jian Xu, Daniel A Nicholson, Anis Contractor
Fragile X syndrome (FXS) is a neurodevelopmental disorder that is a leading cause of inherited intellectual disability, and the most common known cause of autism spectrum disorder (ASD). FXS is broadly characterized by sensory hypersensitivity and several developmental alterations in synaptic and circuit function have been uncovered in the sensory cortex of the mouse model of FXS (Fmr1 KO). GABA mediated neurotransmission and fast-spiking (FS) GABAergic interneurons are central to cortical circuit development in the neonate...
October 16, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29034319/high-precision-fast-spiking-basket-cell-discharges-during-complex-events-in-the-human-neocortex
#12
Viktor Szegedi, Gábor Molnár, Melinda Paizs, Eszter Csakvari, Pál Barzó, Gábor Tamás, Karri Lamsa
In the human neocortex, solitary action potentials in some layer 2-3 pyramidal cells (PCs) trigger brief episodes of network activity known as complex events through strong excitatory synapses that specifically innervate GABAergic interneurons. Yet, how these "master PCs" configure the local network activity is not well understood. We report that single spikes in the PCs, studied here in synaptically connected cell pairs in frontal or temporal neocortical areas of both males and females, elicit firing of fast-spiking basket cells (FSBCs) with a short delay (on average 2...
September 2017: ENeuro
https://www.readbyqxmd.com/read/29028946/mouse-cntnap2-and-human-cntnap2-asd-alleles-cell-autonomously-regulate-pv-cortical-interneurons
#13
Daniel Vogt, Kathleen K A Cho, Samantha M Shelton, Anirban Paul, Z Josh Huang, Vikaas S Sohal, John L R Rubenstein
Human mutations in CNTNAP2 are associated with an array of neuropsychiatric and neurological syndromes, including speech and language disorders, epilepsy, and autism spectrum disorder (ASD). We examined Cntnap2's expression and function in GABAergic cortical interneurons (CINs), where its RNA is present at highest levels in chandelier neurons, PV+ neurons and VIP+ neurons. In vivo functions were studied using both constitutive Cntnap2 null mice and a transplantation assay, the latter to assess cell autonomous phenotypes of medial ganglionic eminence (MGE)-derived CINs...
September 28, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29021744/posterior-thalamic-nucleus-modulation-of-tactile-stimuli-processing-in-rat-motor-and-primary-somatosensory-cortices
#14
Diana Casas-Torremocha, Francisco Clascá, Ángel Núñez
Rodents move rhythmically their facial whiskers and compute differences between signals predicted and those resulting from the movement to infer information about objects near their head. These computations are carried out by a large network of forebrain structures that includes the thalamus and the primary somatosensory (S1BF) and motor (M1wk) cortices. Spatially and temporally precise mechanorreceptive whisker information reaches the S1BF cortex via the ventroposterior medial thalamic nucleus (VPM). Other whisker-related information may reach both M1wk and S1BF via the axons from the posterior thalamic nucleus (Po)...
2017: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/28988851/ablation-of-c-fibers-decreases-quantal-size-of-gabaergic-synaptic-transmission-in-the-insular-cortex
#15
Shota Murayama, Kiyofumi Yamamoto, Mari Kaneko, Bunnai Ogiso, Masayuki Kobayashi
The primary sensory cortex exhibits neuroplastic changes responding to sensory disturbances, and GABAergic synaptic transmission plays a critical role in the regulation of plasticity. The insular cortex (IC) integrates orofacial nociceptive signals conveyed via myelinated Aδ- and unmyelinated C-fibers. However, it has been unknown whether a disturbance of nociceptive inputs, such as a deletion of the peripheral nerves, alters GABAergic local circuit in IC. The present study elucidated GABAergic synaptic transmission in the model rat whose C-fibers were ablated by capsaicin injection 1-2 days after birth...
December 4, 2017: Neuroscience
https://www.readbyqxmd.com/read/28987817/the-sodium-channel-activator-lu-ae98134-normalizes-the-altered-firing-properties-of-fast-spiking-interneurons-in-dlx5-6-mice
#16
Nadia Lybøl von Schoubye, Kristen Frederiksen, Uffe Kristiansen, Anders Victor Petersen, Nils Ole Dalby, Morten Grunnet, Henrik Sindal Jensen, Thomas Jespersen, Vikaas S Sohal, Jean-François Perrier
Mental disorders such as schizophrenia are associated with impaired firing properties of fast spiking inhibitory interneurons (FSINs) causing reduced task-evoked gamma-oscillation in prefrontal cortex. The voltage-gated sodium channel NaV1.1 is highly expressed in PV-positive interneurons, but only at low levels in principal cells. Positive modulators of Nav1.1 channels are for this reason considered potential candidates for the treatment of cognitive disorders. Here we examined the effect of the novel positive modulator of voltage-gated sodium channels Lu AE98134...
October 5, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28985088/modeling-influences-of-dopamine-on-synchronization-behavior-of-striatum
#17
Yüksel Çakir
A network model of striatum that comprises medium spiny neurons (MSNs) and fast spiking interneurons (FSIs) is constructed following the work of Humphries et al. (2009). The dynamic behavior of striatum microcircuit is investigated using a dopamine-modulated modified Izhikevich neuron model. The influences of dopamine on the synchronization behavior of the striatal microcircuit and the dependence on receptor type are investigated with and without time delay. To investigate the role of two types of dopamine receptors, D1 and D2, on the overall activity of the striatum microcircuit, the activities of two groups are considered as disconnected and connected...
2017: Network: Computation in Neural Systems
https://www.readbyqxmd.com/read/28973852/nucleus-accumbens-feedforward-inhibition-circuit-promotes-cocaine-self-administration
#18
Jun Yu, Yijin Yan, King-Lun Li, Yao Wang, Yanhua H Huang, Nathaniel N Urban, Eric J Nestler, Oliver M Schlüter, Yan Dong
The basolateral amygdala (BLA) sends excitatory projections to the nucleus accumbens (NAc) and regulates motivated behaviors partially by activating NAc medium spiny neurons (MSNs). Here, we characterized a feedforward inhibition circuit, through which BLA-evoked activation of NAc shell (NAcSh) MSNs was fine-tuned by GABAergic monosynaptic innervation from adjacent fast-spiking interneurons (FSIs). Specifically, BLA-to-NAcSh projections predominantly innervated NAcSh FSIs compared with MSNs and triggered action potentials in FSIs preceding BLA-mediated activation of MSNs...
October 10, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28949036/subthalamic-nucleus-and-globus-pallidus-interna-influence-firing-of-tonically-active-neurons-in-the-primate-striatum-through-different-mechanisms
#19
Asuka Nakajima, Yasushi Shimo, Takanori Uka, Nobutaka Hattori
Both the subthalamic nucleus (STN) and the globus pallidus pars interna (GPi) are major targets for neuromodulation therapy for movement disorders. An example of such a therapy is deep brain stimulation (DBS). The striatum is the primary target for pharmacological treatment of these disorders. To further our understanding of both the functional relationships among motor nuclei and the mechanisms of therapies for movement disorders, it is important to clarify how changing the neuronal activity of one target, either by medication or by artificial electrical stimulation, affects the other connected nuclei...
September 26, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28947576/interneuronal-network-activity-at-the-onset-of-seizure-like-events-in-entorhinal-cortex-slices
#20
Laura Librizzi, Gabriele Losi, Iacopo Marcon, Michele Sessolo, Paolo Scalmani, Giorgio Carmignoto, Marco de Curtis
The onset of focal seizures in humans and in different animal models of focal epilepsy correlates with reduction of neuronal firing and enhanced interneuronal network activity. Whether this phenomenon contributes to seizure generation is still unclear. We used the in vitro entorhinal cortex slices bathed in 4-aminopirydine (4-AP) as an experimental paradigm model to evaluate the correlation between interneuronal GABAergic network activity and seizure-like events. Epileptiform discharges were recorded in layer V-VI pyramidal neurons and fast-spiking interneurons in slices from male and female mice and in the isolated female guinea pig brain preparation during perfusion with 4-AP...
October 25, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
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