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Fast-spiking interneuron

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https://www.readbyqxmd.com/read/29038238/delayed-maturation-of-fast-spiking-interneurons-is-rectified-by-activation-of-the-trkb-receptor-in-the-mouse-model-of-fragile-x-syndrome
#1
Toshihiro Nomura, Timothy F Musial, John J Marshall, Yiwen Zhu, Christine L Remmers, Jian Xu, Daniel A Nicholson, Anis Contractor
Fragile X syndrome (FXS) is a neurodevelopmental disorder that is a leading cause of inherited intellectual disability, and the most common known cause of autism spectrum disorder (ASD). FXS is broadly characterized by sensory hypersensitivity and several developmental alterations in synaptic and circuit function have been uncovered in the sensory cortex of the mouse model of FXS (Fmr1 KO). GABA mediated neurotransmission and fast-spiking (FS) GABAergic interneurons are central to cortical circuit development in the neonate...
October 16, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29034319/high-precision-fast-spiking-basket-cell-discharges-during-complex-events-in-the-human-neocortex
#2
Viktor Szegedi, Gábor Molnár, Melinda Paizs, Eszter Csakvari, Pál Barzó, Gábor Tamás, Karri Lamsa
In the human neocortex, solitary action potentials in some layer 2-3 pyramidal cells (PCs) trigger brief episodes of network activity known as complex events through strong excitatory synapses that specifically innervate GABAergic interneurons. Yet, how these "master PCs" configure the local network activity is not well understood. We report that single spikes in the PCs, studied here in synaptically connected cell pairs in frontal or temporal neocortical areas of both males and females, elicit firing of fast-spiking basket cells (FSBCs) with a short delay (on average 2...
September 2017: ENeuro
https://www.readbyqxmd.com/read/29028946/mouse-cntnap2-and-human-cntnap2-asd-alleles-cell-autonomously-regulate-pv-cortical-interneurons
#3
Daniel Vogt, Kathleen K A Cho, Samantha M Shelton, Anirban Paul, Z Josh Huang, Vikaas S Sohal, John L R Rubenstein
Human mutations in CNTNAP2 are associated with an array of neuropsychiatric and neurological syndromes, including speech and language disorders, epilepsy, and autism spectrum disorder (ASD). We examined Cntnap2's expression and function in GABAergic cortical interneurons (CINs), where its RNA is present at highest levels in chandelier neurons, PV+ neurons and VIP+ neurons. In vivo functions were studied using both constitutive Cntnap2 null mice and a transplantation assay, the latter to assess cell autonomous phenotypes of medial ganglionic eminence (MGE)-derived CINs...
September 28, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29021744/posterior-thalamic-nucleus-modulation-of-tactile-stimuli-processing-in-rat-motor-and-primary-somatosensory-cortices
#4
Diana Casas-Torremocha, Francisco Clascá, Ángel Núñez
Rodents move rhythmically their facial whiskers and compute differences between signals predicted and those resulting from the movement to infer information about objects near their head. These computations are carried out by a large network of forebrain structures that includes the thalamus and the primary somatosensory (S1BF) and motor (M1wk) cortices. Spatially and temporally precise mechanorreceptive whisker information reaches the S1BF cortex via the ventroposterior medial thalamic nucleus (VPM). Other whisker-related information may reach both M1wk and S1BF via the axons from the posterior thalamic nucleus (Po)...
2017: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/28988851/ablation-of-c-fibers-decreases-quantal-size-of-gabaergic-synaptic-transmission-in-the-insular-cortex
#5
Shota Murayama, Kiyofumi Yamamoto, Mari Kaneko, Bunnai Ogiso, Masayuki Kobayashi
The primary sensory cortex exhibits neuroplastic changes responding to sensory disturbances, and GABAergic synaptic transmission plays a critical role in the regulation of plasticity. The insular cortex (IC) integrates orofacial nociceptive signals conveyed via myelinated Aδ- and unmyelinated C-fibers. However, it has been unknown whether a disturbance of nociceptive inputs, such as a deletion of the peripheral nerves, alters GABAergic local circuit in IC. The present study elucidated GABAergic synaptic transmission in the model rat whose C-fibers were ablated by capsaicin injection 1-2 days after birth...
October 6, 2017: Neuroscience
https://www.readbyqxmd.com/read/28987817/the-sodium-channel-activator-lu-ae98134-normalizes-the-altered-firing-properties-of-fast-spiking-interneurons-in-dlx5-6-mice
#6
Nadia Lybøl von Schoubye, Kristen Frederiksen, Uffe Kristiansen, Anders Victor Petersen, Nils Ole Dalby, Morten Grunnet, Henrik Sindal Jensen, Thomas Jespersen, Vikaas S Sohal, Jean-François Perrier
Mental disorders such as schizophrenia are associated with impaired firing properties of fast spiking inhibitory interneurons (FSINs) causing reduced task-evoked gamma-oscillation in prefrontal cortex. The voltage-gated sodium channel NaV1.1 is highly expressed in PV-positive interneurons, but only at low levels in principal cells. Positive modulators of Nav1.1 channels are for this reason considered potential candidates for the treatment of cognitive disorders. Here we examined the effect of the novel positive modulator of voltage-gated sodium channels Lu AE98134...
October 5, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28985088/modeling-influences-of-dopamine-on-synchronization-behavior-of-striatum
#7
Yüksel Çakir
A network model of striatum that comprises medium spiny neurons (MSNs) and fast spiking interneurons (FSIs) is constructed following the work of Humphries et al. (2009). The dynamic behavior of striatum microcircuit is investigated using a dopamine-modulated modified Izhikevich neuron model. The influences of dopamine on the synchronization behavior of the striatal microcircuit and the dependence on receptor type are investigated with and without time delay. To investigate the role of two types of dopamine receptors, D1 and D2, on the overall activity of the striatum microcircuit, the activities of two groups are considered as disconnected and connected...
October 6, 2017: Network: Computation in Neural Systems
https://www.readbyqxmd.com/read/28973852/nucleus-accumbens-feedforward-inhibition-circuit-promotes-cocaine-self-administration
#8
Jun Yu, Yijin Yan, King-Lun Li, Yao Wang, Yanhua H Huang, Nathaniel N Urban, Eric J Nestler, Oliver M Schlüter, Yan Dong
The basolateral amygdala (BLA) sends excitatory projections to the nucleus accumbens (NAc) and regulates motivated behaviors partially by activating NAc medium spiny neurons (MSNs). Here, we characterized a feedforward inhibition circuit, through which BLA-evoked activation of NAc shell (NAcSh) MSNs was fine-tuned by GABAergic monosynaptic innervation from adjacent fast-spiking interneurons (FSIs). Specifically, BLA-to-NAcSh projections predominantly innervated NAcSh FSIs compared with MSNs and triggered action potentials in FSIs preceding BLA-mediated activation of MSNs...
September 25, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28949036/subthalamic-nucleus-and-globus-pallidus-interna-influence-firing-of-tonically-active-neurons-in-the-primate-striatum-through-different-mechanisms
#9
Asuka Nakajima, Yasushi Shimo, Takanori Uka, Nobutaka Hattori
Both the subthalamic nucleus (STN) and the globus pallidus pars interna (GPi) are major targets for neuromodulation therapy for movement disorders. An example of such a therapy is deep brain stimulation (DBS). The striatum is the primary target for pharmacological treatment of these disorders. To further our understanding of both the functional relationships among motor nuclei and the mechanisms of therapies for movement disorders, it is important to clarify how changing the neuronal activity of one target, either by medication or by artificial electrical stimulation, affects the other connected nuclei...
September 26, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28947576/interneuronal-network-activity-at-the-onset-of-seizure-like-events-in-entorhinal-cortex-slices
#10
Laura Librizzi, Gabriele Losi, Iacopo Marcon, Michele Sessolo, Paolo Scalmani, Giorgio Carmignoto, Marco de Curtis
The onset of focal seizures in humans and in different animal models of focal epilepsy correlates with reduction of neuronal firing and enhanced interneuronal network activity. Whether this phenomenon contributes to seizure generation is still unclear. We utilized the in vitro entorhinal cortex slices bathed in 4-aminopirydine as an experimental paradigm model to evaluate the correlation between interneuronal GABAergic network activity and seizure-like events. Epileptiform discharges were recorded in layer V-VI pyramidal neurons and fast-spiking interneurons in slices from male and female mice and in the isolated female guinea pig brain preparation during perfusion with 4-AP...
September 25, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28922832/fast-spiking-parvalbumin-interneurons-are-frequently-myelinated-in-the-cerebral-cortex-of-mice-and-humans
#11
J Stedehouder, J J Couey, D Brizee, B Hosseini, J A Slotman, C M F Dirven, G Shpak, A B Houtsmuller, S A Kushner
Myelination, the insulating ensheathment of axons by oligodendrocytes, is thought to both optimize signal propagation and provide metabolic support. Despite the well-established physiological importance of myelination to neuronal function, relatively little is known about the myelination of GABAergic interneurons in the cerebral cortex. Here, we report that a large fraction of myelin in mouse cerebral cortex ensheaths GABAergic interneurons, reaching up to 80% in hippocampal subregions. Moreover, we find that a very high proportion of neocortical and hippocampal parvalbumin (PV) interneurons exhibit axonal myelination...
October 1, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28921856/disruption-of-perineuronal-nets-increases-the-frequency-of-sharp-wave-ripple-events
#12
Zhi Yong Sun, P Lorenzo Bozzelli, Adam Caccavano, Megan Allen, Jason Balmuth, Stefano Vicini, Jian-Young Wu, Katherine Conant
Hippocampal sharp wave ripples (SWRs) represent irregularly occurring synchronous neuronal population events that are observed during phases of rest and slow wave sleep. SWR activity that follows learning involves sequential replay of training-associated neuronal assemblies and is critical for systems level memory consolidation. SWRs are initiated by CA2 or CA3 pyramidal cells (PCs) and require initial excitation of CA1 PCs as well as participation of parvalbumin (PV) expressing fast spiking (FS) inhibitory interneurons...
September 16, 2017: Hippocampus
https://www.readbyqxmd.com/read/28910740/generation-of-low-gamma-oscillations-in-a-gabaergic-network-model-of-the-striatum
#13
Zhihua Wu, Aike Guo, Xiaodi Fu
Striatal oscillations in the low-gamma frequency range have been consistently recorded in a number of experimental studies. However, whether these rhythms are locally generated in the striatum circuit, which is mainly composed of GABAergic neurons, remains an open question. GABAergic medium spiny projection neurons represent the great majority of striatal neurons, but they fire at very low rates. GABAergic fast-spiking interneurons typically show firing rates that are approximately 10 times higher than those of principal neurons, but they are a very small minority of the total neuronal population...
November 2017: Neural Networks: the Official Journal of the International Neural Network Society
https://www.readbyqxmd.com/read/28904001/kv3-channels-enablers-of-rapid-firing-neurotransmitter-release-and-neuronal-endurance
#14
REVIEW
Leonard K Kaczmarek, Yalan Zhang
The intrinsic electrical characteristics of different types of neurons are shaped by the K(+) channels they express. From among the more than 70 different K(+) channel genes expressed in neurons, Kv3 family voltage-dependent K(+) channels are uniquely associated with the ability of certain neurons to fire action potentials and to release neurotransmitter at high rates of up to 1,000 Hz. In general, the four Kv3 channels Kv3.1-Kv3.4 share the property of activating and deactivating rapidly at potentials more positive than other channels...
October 1, 2017: Physiological Reviews
https://www.readbyqxmd.com/read/28875311/bisphenol-a-exposure-perturbs-visual-function-of-adult-cats-by-remodeling-the-neuronal-activity-in-the-primary-visual-pathway
#15
Guangwei Xu, Fan Hu, Xuan Wang, Bing Zhang, Yifeng Zhou
Bisphenol A (BPA), a common environmental xenoestrogen, has been implicated in physiological and behavioral impairment, but the neuronal basis remains elusive. Although various synaptic mechanisms have been shown to mediate BPA-induced brain deficits, there are almost no reports addressing its underlying physiological mechanisms at the individual neuron level, particularly in the primary visual system. In the present study, using multiple-channel recording technique, we recorded the responses of single neurons in the primary visual system of cats to various direction stimuli both before and after BPA exposure...
September 5, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28871960/striatal-fast-spiking-interneurons-selectively-modulate-circuit-output-and-are-required-for-habitual-behavior
#16
Justin K O'Hare, Haofang Li, Namsoo Kim, Erin Gaidis, Kristen Ade, Jeff Beck, Henry Yin, Nicole Calakos
Habit formation is a behavioral adaptation that automates routine actions. Habitual behavior correlates with broad reconfigurations of dorsolateral striatal (DLS) circuit properties that increase gain and shift pathway timing. The mechanism(s) for these circuit adaptations are unknown and could be responsible for habitual behavior. Here we find that a single class of interneuron, fast-spiking interneurons (FSIs), modulates all of these habit-predictive properties. Consistent with a role in habits, FSIs are more excitable in habitual mice compared to goal-directed and acute chemogenetic inhibition of FSIs in DLS prevents the expression of habitual lever pressing...
September 5, 2017: ELife
https://www.readbyqxmd.com/read/28844658/direct-reprogramming-of-resident-ng2-glia-into-neurons-with-properties-of-fast-spiking-parvalbumin-containing-interneurons
#17
Maria Pereira, Marcella Birtele, Shelby Shrigley, Julio Aguila Benitez, Eva Hedlund, Malin Parmar, Daniella Rylander Ottosson
Converting resident glia into functional and subtype-specific neurons in vivo by delivering reprogramming genes directly to the brain provides a step forward toward the possibility of treating brain injuries or diseases. To date, it has been possible to obtain GABAergic and glutamatergic neurons via in vivo conversion, but the precise phenotype of these cells has not yet been analyzed in detail. Here, we show that neurons reprogrammed using Ascl1, Lmx1a, and Nurr1 functionally mature and integrate into existing brain circuitry and that the majority of the reprogrammed neurons have properties of fast-spiking, parvalbumin-containing interneurons...
September 12, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28794441/tgf%C3%AE-signaling-is-associated-with-changes-in-inflammatory-gene-expression-and-perineuronal-net-degradation-around-inhibitory-neurons-following-various-neurological-insults
#18
Soo Young Kim, Vladimir V Senatorov, Christapher S Morrissey, Kristina Lippmann, Oscar Vazquez, Dan Z Milikovsky, Feng Gu, Isabel Parada, David A Prince, Albert J Becker, Uwe Heinemann, Alon Friedman, Daniela Kaufer
Brain damage due to stroke or traumatic brain injury (TBI), both leading causes of serious long-term disability, often leads to the development of epilepsy. Patients who develop post-injury epilepsy tend to have poor functional outcomes. Emerging evidence highlights a potential role for blood-brain barrier (BBB) dysfunction in the development of post-injury epilepsy. However, common mechanisms underlying the pathological hyperexcitability are largely unknown. Here, we show that comparative transcriptome analyses predict remodeling of extracellular matrix (ECM) as a common response to different types of injuries...
August 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28774782/does-layer-4-in-the-barrel-cortex-function-as-a-balanced-circuit-when-responding-to-whisker-movements
#19
Tommer Argaman, David Golomb
Neurons in one barrel in layer 4 (L4) in the mouse vibrissa somatosensory cortex are innervated mostly by neurons from the VPM nucleus and by other neurons within the same barrel. During quiet wakefulness or whisking in air, thalamic inputs vary slowly in time, and excitatory neurons rarely fire. A barrel in L4 contains a modest amount of neurons; the synaptic conductances are not very strong and connections are not sparse. Are the dynamical properties of the L4 circuit similar to those expected from fluctuation-dominated, balanced networks observed for large, strongly coupled and sparse cortical circuits? To resolve this question, we analyze a network of 150 inhibitory parvalbumin-expressing fast-spiking inhibitory interneurons innervated by the VPM thalamus with random connectivity, without or with 1600 low-firing excitatory neurons...
August 1, 2017: Neuroscience
https://www.readbyqxmd.com/read/28769764/gap-junctions-link-regular-spiking-and-fast-spiking-interneurons-in-layer-5-somatosensory-cortex
#20
Robert J Hatch, G Dulini C Mendis, Kai Kaila, Christopher A Reid, Steven Petrou
Gap junctions form electrical synapses that modulate neuronal activity by synchronizing action potential (AP) firing of cortical interneurons (INs). Gap junctions are thought to form predominantly within cortical INs of the same functional class and are therefore considered to act within discrete neuronal populations. Here, we challenge that view and show that the probability of electrical coupling is the same within and between regular-spiking (RS) and fast-spiking (FS) cortical INs in 16-21 days old mice...
2017: Frontiers in Cellular Neuroscience
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