keyword
MENU ▼
Read by QxMD icon Read
search

Fast-spiking interneuron

keyword
https://www.readbyqxmd.com/read/27911814/distinct-cortical-and-striatal-actions-of-a-%C3%AE-arrestin-biased-dopamine-d2-receptor-ligand-reveal-unique-antipsychotic-like-properties
#1
Nikhil M Urs, Steven M Gee, Thomas F Pack, John D McCorvy, Tama Evron, Joshua C Snyder, Xiaobao Yang, Ramona M Rodriguiz, Emiliana Borrelli, William C Wetsel, Jian Jin, Bryan L Roth, Patricio O'Donnell, Marc G Caron
The current dopamine (DA) hypothesis of schizophrenia postulates striatal hyperdopaminergia and cortical hypodopaminergia. Although partial agonists at DA D2 receptors (D2Rs), like aripiprazole, were developed to simultaneously target both phenomena, they do not effectively improve cortical dysfunction. In this study, we investigate the potential for newly developed β-arrestin2 (βarr2)-biased D2R partial agonists to simultaneously target hyper- and hypodopaminergia. Using neuron-specific βarr2-KO mice, we show that the antipsychotic-like effects of a βarr2-biased D2R ligand are driven through both striatal antagonism and cortical agonism of D2R-βarr2 signaling...
December 1, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27828957/plasticity-in-single-axon-glutamatergic-connection-to-gabaergic-interneurons-regulates-complex-events-in-the-human-neocortex
#2
Viktor Szegedi, Melinda Paizs, Eszter Csakvari, Gabor Molnar, Pal Barzo, Gabor Tamas, Karri Lamsa
In the human neocortex, single excitatory pyramidal cells can elicit very large glutamatergic EPSPs (VLEs) in inhibitory GABAergic interneurons capable of triggering their firing with short (3-5 ms) delay. Similar strong excitatory connections between two individual neurons have not been found in nonhuman cortices, suggesting that these synapses are specific to human interneurons. The VLEs are crucial for generating neocortical complex events, observed as single pyramidal cell spike-evoked discharge of cell assemblies in the frontal and temporal cortices...
November 2016: PLoS Biology
https://www.readbyqxmd.com/read/27807408/cortical-neural-computation-by-discrete-results-hypothesis
#3
REVIEW
Carlos Castejon, Angel Nuñez
One of the most challenging problems we face in neuroscience is to understand how the cortex performs computations. There is increasing evidence that the power of the cortical processing is produced by populations of neurons forming dynamic neuronal ensembles. Theoretical proposals and multineuronal experimental studies have revealed that ensembles of neurons can form emergent functional units. However, how these ensembles are implicated in cortical computations is still a mystery. Although cell ensembles have been associated with brain rhythms, the functional interaction remains largely unclear...
2016: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/27806991/hippocampal-perineuronal-nets-are-required-for-the-sustained-antidepressant-effect-of-ketamine
#4
Jennifer J Donegan, Daniel J Lodge
BACKGROUND: NMDA receptor antagonists, like ketamine, produce a rapid-acting and long-lasting antidepressant effect. Although the mechanism is not completely understood, ketamine is thought to preferentially target NMDA receptors on fast-spiking parvalbumin (PV)-containing interneurons. The function of PV-containing interneurons is dependent on perineuronal nets, a specialized form of extracellular matrix that surrounds these cells. METHODS: Chondroitinase was used to enzymatically degrade perineuronal nets surrounding PV-containing interneurons in the ventral hippocampus (vHipp), a region that is involved in the antidepressant response to ketamine...
November 2, 2016: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27793780/%C3%AE-4%C3%AE-2-%C3%A2-nicotinic-receptors-stimulate-gaba-release-onto-fast-spiking-cells-in-layer-v-of-mouse-prefrontal-fr2-cortex
#5
Patrizia Aracri, Simone Meneghini, Aurora Coatti, Alida Amadeo, Andrea Becchetti
Nicotinic acetylcholine receptors (nAChRs) produce widespread and complex effects on neocortex excitability. We studied how heteromeric nAChRs regulate inhibitory post-synaptic currents (IPSCs), in fast-spiking (FS) layer V neurons of the mouse frontal area 2 (Fr2). In the presence of blockers of ionotropic glutamate receptors, tonic application of 10μM nicotine augmented the spontaneous IPSC frequency, with minor alterations of amplitudes and kinetics. These effects were studied since the 3rd postnatal week, and persisted throughout the first two months of postnatal life...
October 26, 2016: Neuroscience
https://www.readbyqxmd.com/read/27783219/long-term-plasticity-in-identified-hippocampal-gabaergic-interneurons-in-the-ca1-area-in-vivo
#6
Petrina Yau-Pok Lau, Linda Katona, Peter Saghy, Kathryn Newton, Peter Somogyi, Karri P Lamsa
Long-term plasticity is well documented in synapses between glutamatergic principal cells in the cortex both in vitro and in vivo. Long-term potentiation (LTP) and -depression (LTD) have also been reported in glutamatergic connections to hippocampal GABAergic interneurons expressing parvalbumin (PV+) or nitric oxide synthase (NOS+) in brain slices, but plasticity in these cells has not been tested in vivo. We investigated synaptically-evoked suprathreshold excitation of identified hippocampal neurons in the CA1 area of urethane-anaesthetized rats...
October 25, 2016: Brain Structure & Function
https://www.readbyqxmd.com/read/27780732/altered-postnatal-maturation-of-striatal-gabaergic-interneurons-in-a-phenotypic-animal-model-of-dystonia
#7
Christoph Bode, Franziska Richter, Christine Spröte, Tanja Brigadski, Anne Bauer, Simone Fietz, Jean-Marc Fritschy, Angelika Richter
GABAergic disinhibition has been suggested to play a critical role in the pathophysiology of several basal ganglia disorders, including dystonia, a common movement disorder. Previous studies have shown a deficit of striatal GABAergic interneurons (IN) in the dt(sz) mutant hamster, one of the few phenotypic animal models of dystonia. However, mechanisms underlying this deficit are largely unknown. In the present study, we investigated the migration and maturation of striatal IN during postnatal development (18days of age) and at age of highest severity of dystonia (33days of age) in this hamster model...
January 2017: Experimental Neurology
https://www.readbyqxmd.com/read/27749825/layer-4-fast-spiking-interneurons-filter-thalamocortical-signals-during-active-somatosensation
#8
Jianing Yu, Diego A Gutnisky, S Andrew Hires, Karel Svoboda
We rely on movement to explore the environment, for example, by palpating an object. In somatosensory cortex, activity related to movement of digits or whiskers is suppressed, which could facilitate detection of touch. Movement-related suppression is generally assumed to involve corollary discharges. Here we uncovered a thalamocortical mechanism in which cortical fast-spiking interneurons, driven by sensory input, suppress movement-related activity in layer 4 (L4) excitatory neurons. In mice locating objects with their whiskers, neurons in the ventral posteromedial nucleus (VPM) fired in response to touch and whisker movement...
October 17, 2016: Nature Neuroscience
https://www.readbyqxmd.com/read/27733597/changes-in-activity-of-fast-spiking-interneurons-of-the-monkey-striatum-during-reaching-at-a-visual-target
#9
Kévin Marche, Paul Apicella
Recent works highlight the importance of local inhibitory interneurons in regulating the function of the striatum. In particular, fast-spiking interneurons (FSIs), which likely correspond to a subgroup of GABAergic interneurons, have been involved in the control of movement by exerting strong inhibition on striatal output pathways. However, little is known about the exact contribution of these presumed interneurons in movement preparation, initiation, and execution. We recorded the activity of FSIs in the striatum of monkeys as they performed reaching movements to a visual target under two task conditions: one in which the movement target was presented at unsignaled left or right locations, and another in which advance information about target location was available, thus allowing monkeys to react faster...
October 12, 2016: Journal of Neurophysiology
https://www.readbyqxmd.com/read/27726011/analysis-of-spontaneous-activity-of-superficial-dorsal-horn-neurons-in-vitro-neuropathy-induced-changes
#10
Carolina Roza, Irene Mazo, Iván Rivera-Arconada, Elsa Cisneros, Ismel Alayón, José A López-García
The superficial dorsal horn contains large numbers of interneurons which process afferent and descending information to generate the spinal nociceptive message. Here, we set out to evaluate whether adjustments in patterns and/or temporal correlation of spontaneous discharges of these neurons are involved in the generation of central sensitization caused by peripheral nerve damage. Multielectrode arrays were used to record from discrete groups of such neurons in slices from control or nerve damaged mice. Whole-cell recordings of individual neurons were also obtained...
October 10, 2016: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/27725218/opioid-subtype-and-cell-type-dependent-regulation-of-inhibitory-synaptic-transmission-in-the-rat-insular-cortex
#11
Eiko Yokota, Yuko Koyanagi, Kiyofumi Yamamoto, Yoshiyuki Oi, Noriaki Koshikawa, Masayuki Kobayashi
The insular cortex (IC) plays a principal role in the regulation of pain processing. Although opioidergic agonists depress cortical excitatory synaptic transmission, little is known about opioidergic roles in inhibitory synaptic transmission. In the IC, the opioid receptors differentially regulate the excitatory propagation: agonists of the mu (MOR), delta (DOR), and kappa (KOR) exhibit suppressive, facilitative, and little effects, respectively. Thus, we aimed to examine the effects of opioid receptor agonists on unitary inhibitory postsynaptic currents (uIPSCs) in the IC...
December 17, 2016: Neuroscience
https://www.readbyqxmd.com/read/27720623/intraspinal-sensory-neurons-provide-powerful-inhibition-to-motor-circuits-ensuring-postural-control-during-locomotion
#12
Jeffrey Michael Hubbard, Urs Lucas Böhm, Andrew Prendergast, Po-En Brian Tseng, Morgan Newman, Caleb Stokes, Claire Wyart
In the vertebrate spinal cord, cerebrospinal fluid-contacting neurons (CSF-cNs) are GABAergic neurons whose functions are only beginning to unfold. Recent evidence indicates that CSF-cNs detect local spinal bending and relay this mechanosensory feedback information to motor circuits, yet many CSF-cN targets remain unknown. Using optogenetics, patterned illumination, and in vivo electrophysiology, we show here that CSF-cNs provide somatic inhibition to fast motor neurons and excitatory sensory interneurons involved in the escape circuit...
October 4, 2016: Current Biology: CB
https://www.readbyqxmd.com/read/27710792/principles-of-synaptic-organization-of-gabaergic-interneurons-in-the-striatum
#13
Christoph Straub, Jessica Lizette Saulnier, Aurelien Bègue, Danielle D Feng, Kee Wui Huang, Bernardo Luis Sabatini
The striatum, the entry nucleus of the basal ganglia, lacks laminar or columnar organization of its principal cells; nevertheless, functional data suggest that it is spatially organized. Here we examine whether the connectivity and synaptic organization of striatal GABAergic interneurons contributes to such spatial organization. Focusing on the two main classes of striatal GABAergic interneurons (fast-spiking interneurons [FSIs] and low-threshold-spiking interneurons [LTSIs]), we apply a combination of optogenetics and viral tracing approaches to dissect striatal microcircuits in mice...
October 5, 2016: Neuron
https://www.readbyqxmd.com/read/27707966/neuregulin-dependent-regulation-of-fast-spiking-interneuron-excitability-controls-the-timing-of-the-critical-period
#14
Yu Gu, Trinh Tran, Sachiko Murase, Andrew Borrell, Alfredo Kirkwood, Elizabeth M Quinlan
: Maturation of excitatory drive onto fast-spiking interneurons (FS INs) in the visual cortex has been implicated in the control of the timing of the critical period for ocular dominance plasticity. However, the mechanisms that regulate the strength of these synapses over cortical development are not understood. Here we use a mouse model to show that neuregulin (NRG) and the receptor tyrosine kinase erbB4 regulate the timing of the critical period. NRG1 enhanced the strength of excitatory synapses onto FS INs, which inhibited ocular dominance plasticity during the critical period but rescued plasticity in transgenics with hypoexcitable FS INs...
October 5, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27679813/using-a-semi-automated-strategy-to-develop-multi-compartment-models-that-predict-biophysical-properties-of-interneuron-specific-3-is3-cells-in-hippocampus
#15
Alexandre Guet-McCreight, Olivier Camiré, Lisa Topolnik, Frances K Skinner
Determining how intrinsic cellular properties govern and modulate neuronal input-output processing is a critical endeavor for understanding microcircuit functions in the brain. However, lack of cellular specifics and nonlinear interactions prevent experiments alone from achieving this. Building and using cellular models is essential in these efforts. We focus on uncovering the intrinsic properties of mus musculus hippocampal type 3 interneuron-specific (IS3) cells, a cell type that makes GABAergic synapses onto specific interneuron types, but not pyramidal cells...
July 2016: ENeuro
https://www.readbyqxmd.com/read/27646261/myelination-of-parvalbumin-interneurons-a-parsimonious-locus-of-pathophysiological-convergence-in-schizophrenia
#16
J Stedehouder, S A Kushner
Schizophrenia is a debilitating psychiatric disorder characterized by positive, negative and cognitive symptoms. Despite more than a century of research, the neurobiological mechanism underlying schizophrenia remains elusive. White matter abnormalities and interneuron dysfunction are the most widely replicated cellular neuropathological alterations in patients with schizophrenia. However, a unifying model incorporating these findings has not yet been established. Here, we propose that myelination of fast-spiking parvalbumin (PV) interneurons could be an important locus of pathophysiological convergence in schizophrenia...
September 20, 2016: Molecular Psychiatry
https://www.readbyqxmd.com/read/27629860/myoclonus-epilepsy-and-ataxia-due-to-potassium-channel-mutation-meak-is-caused-by-heterozygous-kcnc1-mutations
#17
Fábio A Nascimento, Danielle M Andrade
Progressive myoclonus epilepsy (PME) is a distinct group of seizure disorders characterized by gradual neurological decline with ataxia, myoclonus and recurring seizures. There are several forms of PME, among which the most recently described is MEAK - myoclonus epilepsy and ataxia due to potassium channel mutation. This particular subtype is caused by a recurrent de novo heterozygous mutation (c.959G>A, p.Arg320His) in the KCNC1 gene, which maps to chromosome 11 and encodes for the Kv3.1 protein (a subunit of the Kv3 subfamily of voltage-gated potassium channels)...
September 1, 2016: Epileptic Disorders: International Epilepsy Journal with Videotape
https://www.readbyqxmd.com/read/27628208/social-context-differentially-modulates-activity-of-two-interneuron-populations-in-an-avian-basal-ganglia-nucleus
#18
Sarah Cushing Woolley
Basal ganglia circuits are critical for the modulation of motor performance across behavioral states. In zebra finches, a cortical-basal ganglia circuit dedicated to singing is necessary for males adjust their song performance and transition between spontaneous singing, when they are alone ('undirected' song), and a performance state when they sing to a female ('female-directed song'). However, we know little about the role of different basal ganglia cell types in this behavioral transition or the degree to which behavioral context modulates the activity of different neuron classes...
September 14, 2016: Journal of Neurophysiology
https://www.readbyqxmd.com/read/27620551/binge-like-alcohol-exposure-during-adolescence-disrupts-dopaminergic-neurotransmission-in-the-adult-prelimbic-cortex
#19
Heather Trantham-Davidson, Samuel W Centanni, S Corrin Garr, Natasha N New, Patrick J Mulholland, Justin T Gass, Elizabeth J Glover, Stan B Floresco, Fulton T Crews, Harish R Krishnan, Subhash C Pandey, L Judson Chandler
Repeated binge-like exposure to alcohol during adolescence has been reported to perturb prefrontal cortical development, yet the mechanisms underlying these effects are unknown. Here we report that adolescent intermittent ethanol exposure induces cellular and dopaminergic abnormalities in the adult prelimbic cortex (PrL-C). Exposing rats to alcohol during early-mid adolescence (PD28-42) increased the density of long/thin dendritic spines of layer 5 pyramidal neurons in the adult PrL-C. Interestingly, although AIE exposure did not alter the expression of glutamatergic proteins in the adult PrL-C, there was a pronounced reduction in dopamine (DA) D1 receptor modulation of both intrinsic firing and evoked NMDA currents in pyramidal cells, whereas D2 receptor function was unaltered...
September 13, 2016: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27611660/pten-and-ephb4-regulate-the-establishment-of-perisomatic-inhibition-in-mouse-visual-cortex
#20
Amy Baohan, Taruna Ikrar, Elaine Tring, Xiangmin Xu, Joshua T Trachtenberg
Perisomatic inhibition of pyramidal neurons is established by fast-spiking, parvalbumin-expressing interneurons (PV cells). Failure to assemble adequate perisomatic inhibition is thought to underlie the aetiology of neurological dysfunction in seizures, autism spectrum disorders and schizophrenia. Here we show that in mouse visual cortex, strong perisomatic inhibition does not develop if PV cells lack a single copy of Pten. PTEN signalling appears to drive the assembly of perisomatic inhibition in an experience-dependent manner by suppressing the expression of EphB4; PV cells hemizygous for Pten show an ∼2-fold increase in expression of EphB4, and over-expression of EphB4 in adult PV cells causes a dismantling of perisomatic inhibition...
2016: Nature Communications
keyword
keyword
104011
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"