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https://www.readbyqxmd.com/read/28706748/comparison-of-globus-pallidus-interna-and-subthalamic-nucleus-in-deep-brain-stimulation-for-parkinson-disease-an-institutional-experience-and-review
#1
REVIEW
Shazia Mirza, Umar Yazdani, Richard Dewey Iii, Neepa Patel, Richard B Dewey, Svjetlana Miocinovic, Shilpa Chitnis
Deep Brain Stimulation (DBS) has revolutionized the lives of patients of Parkinson disease, offering therapeutic options to those not benefiting entirely from medications alone. With its proven track record of outperforming the best medical management, the goal is to unlock the full potential of this therapy. Currently, the Globus Pallidus Interna (GPi) and Subthalamic Nucleus (STN) are both viable targets for DBS, and the choice of site should focus on the constellation of symptoms, both motor and nonmotor, which are key determinants to quality of life...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28693029/angio-oct-de-la-zona-avascular-foveal-en-ojos-con-oclusi%C3%A3-n-venosa-de-la-retina
#2
Juliana Wons, Maximilian Pfau, Magdalena A Wirth, Florentina J Freiberg, Matthias D Becker, Stephan Michels
Objetivo: El objetivo del estudio comprendía visualizar y cuantificar las alteraciones patológicas de la zona avascular foveal (ZAF) mediante angio-OCT en ojos con oclusión venosa de la retina (OVR) en comparación con el ojo contralateral sano. Procedimientos: La angio-OCT se llevó a cabo mediante el sistema Avanti® RTVue 100 XR (Optovue Inc., Fremont, Calif., EE. UU.). Los bordes de la capa vascular superficial (CVS) se definieron como 3 μm por debajo de la membrana limitante interna y 15 μm por debajo de la capa plexiforme interna y, para la capa vascular profunda (CVP), como 15 y 70 μm por debajo de la membrana limitante interna y de la capa plexiforme interna, respectivamente...
July 11, 2017: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/28693020/propiedades-biomec%C3%A3-nicas-de-la-membrana-limitante-interna-tras-recibir-tratamiento-intrav%C3%A3-treo-con-ocriplasmina
#3
Franziska Vielmuth, Ricarda G Schumann, Volker Spindler, Armin Wolf, Renate Scheler, Wolfgang J Mayer, Paul B Henrich, Christos Haritoglou
Objetivo: Evaluar la rigidez de la membrana limitante interna (MLI) humana y evaluar los posibles cambios de las propiedades mecánicas tras administrar una inyección intravítrea de ocriplasmina para tratar la tracción vitreomacular. Métodos: Este estudio se compone de una serie de casos intervencionales y comparativos de 12 muestras de MLI extraídas mediante cirugía y obtenidas de forma consecutiva de 9 ojos de 9 pacientes después de someterse sin éxito a vitreólisis farmacológica con ocriplasmina...
2017: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/28680884/white-matter-injury-and-recovery-after-hypertensive-intracerebral-hemorrhage
#4
REVIEW
Shilun Zuo, Pengyu Pan, Qiang Li, Yujie Chen, Hua Feng
Hypertensive intracerebral hemorrhage (ICH) could very probably trigger white matter injury in patients. Through the continuous study of white matter injury after hypertensive ICH, we achieve a more profound understanding of the pathophysiological mechanism of its occurrence and development. At the same time, we found a series of drugs and treatment methods for the white matter repair. In the current reality, the research paradigm of white matter injury after hypertensive ICH is relatively obsolete or incomplete, and there are still lots of deficiencies in the research...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28678930/ruthenium-complex-improves-the-endothelial-function-in-aortic-rings-from-hypertensive-rats
#5
Izabela Pereira Vatanabe, Carla Nascimento Dos Santos Rodrigues, Tereza Cristina Buzinari, Thiago Francisco de Moraes, Roberto Santana da Silva, Gerson Jhonatan Rodrigues
Background: The endothelium is a monolayer of cells that extends on the vascular inner surface, responsible for the modulation of vascular tone. By means of the release of nitric oxide (NO), the endothelium has an important protective function against cardiovascular diseases. Objective: Verify if cis- [Ru(bpy)2(NO2)(NO)](PF6)2 (BPY) improves endothelial function and the sensibility of conductance (aorta) and resistance (coronary) to vascular relaxation induced by BPY...
June 29, 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28678878/the-bigger-the-better-volume-measurements-of-parasites-and-hosts-parasitic-barnacles-cirripedia-rhizocephala-and-their-decapod-hosts
#6
Christina Nagler, Marie K Hörnig, Joachim T Haug, Christoph Noever, Jens T Høeg, Henrik Glenner
Rhizocephala, a group of parasitic castrators of other crustaceans, shows remarkable morphological adaptations to their lifestyle. The adult female parasite consists of a body that can be differentiated into two distinct regions: a sac-like structure containing the reproductive organs (the externa), and a trophic, root like system situated inside the hosts body (the interna). Parasitism results in the castration of their hosts, achieved by absorbing the entire reproductive energy of the host. Thus, the ratio of the host and parasite sizes is crucial for the understanding of the parasite's energetic cost...
2017: PloS One
https://www.readbyqxmd.com/read/28677169/fibre-dissection-and-sectional-study-of-the-major-porcine-cerebral-white-matter-tracts
#7
R Pascalau, B Szabo
White matter anatomy is the basis for numerous applications in neurology, neurosurgery and fundamental neuroscience. Although the porcine brain is frequently used as experimental model in these fields of research, the description of its white matter is not as thorough as in the human brain or other species. Thus, the aim of this study is to describe the porcine white matter tracts in a complex manner. Two stepwise dissection protocols adapted from human anatomy were performed on six adult pig brain hemispheres prepared according to the Klingler method...
July 4, 2017: Anatomia, Histologia, Embryologia
https://www.readbyqxmd.com/read/28676986/incidental-findings-on-cerebral-mri-in-twins-the-older-australian-twins-study
#8
Rebecca Koncz, Adith Mohan, Laughlin Dawes, Anbupalam Thalamuthu, Margaret Wright, David Ames, Teresa Lee, Julian Trollor, Wei Wen, Perminder Sachdev
Incidental findings on structural cerebral magnetic resonance imaging (MRI) are common in healthy subjects, and the prevalence increases with age. There is a paucity of data regarding incidental cerebral findings in twins. We examined brain MRI data acquired from community-dwelling older twins to determine the prevalence and concordance of incidental cerebral findings, as well as the associated clinical implications. Participants (n = 400) were drawn from the Older Australian Twins Study. T1-weighted and T2-weighted fluid-attenuated inversion recovery (FLAIR) cerebral MRI scans were systematically reviewed by a trained, blinded clinician...
July 4, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28676057/prevalence-of-neurological-disorders-in-french-bulldog-a-retrospective-study-of-343-cases-2002-2016
#9
Vincent Mayousse, Loïc Desquilbet, Aurélien Jeandel, Stéphane Blot
BACKGROUND: French Bulldog (FB) has significantly gained in popularity over the last few years, and seems to be frequently affected by various neurological conditions. The purpose of this retrospective study was to report the prevalences of neurological diseases in a large population of FB, presented with neurological signs between 2002 and 2016, and for which a definitive diagnosis was established. A secondary objective was to identify epidemiological characteristics regarding specific diseases in this singular breed...
July 5, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28666032/pulmonary-vascular-changes-in-extremely-preterm-sheep-after-intra-amniotic-exposure-to-ureaplasma-parvum-and-lipopolysaccharide
#10
Monique G M Willems, Matthew W Kemp, Laura A Fast, Nick M M Wagemaker, Leon E W Janssen, John P Newnham, Matt S Payne, Owen B Spiller, Suhas G Kallapur, Alan H Jobe, Tammo Delhaas, Boris W Kramer, Tim G A M Wolfs
BACKGROUND: Chorioamnionitis can induce pulmonary inflammation and promote bronchopulmonary dysplasia development, distinguished by alveolar simplification and impaired vascular growth. Chorioamnionitis is more common during the extremely preterm canalicular lung stage (crucial for vascular development); and increases the risk for subsequent sepsis. We hypothesized that single/combined exposure to chronic and/or acute inflammation induces pulmonary inflammatory responses and vascular changes...
2017: PloS One
https://www.readbyqxmd.com/read/28665252/deep-brain-stimulation-for-parkinson-s-disease-meta-analysis-of-results-of-randomized-trials-at-varying-lengths-of-follow-up
#11
Alireza Mansouri, Shervin Taslimi, Jetan H Badhiwala, Christopher D Witiw, Farshad Nassiri, Vincent J J Odekerken, Rob M A De Bie, Suneil K Kalia, Mojgan Hodaie, Renato P Munhoz, Alfonso Fasano, Andres M Lozano
OBJECTIVE Deep brain stimulation (DBS) is effective in the management of patients with advanced Parkinson's disease (PD). While both the globus pallidus pars interna (GPi) and the subthalamic nucleus (STN) are accepted targets, their relative efficacy in randomized controlled trials (RCTs) has not been established beyond 12 months. The objective of this study was to conduct a meta-analysis of RCTs to compare outcomes among adults with PD undergoing DBS of GPi or STN at various time points, including 36 months of follow-up...
June 30, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28645616/epidemiological-and-sociodemographic-factors-associated-with-complicated-alcohol-withdrawal-syndrome
#12
R Monte-Secades, M Blanco-Soto, J A Díaz-Peromingo, A Sanvisens-Bergé, M C Martín-González, A Barbosa, B Rosón-Hernández, M A Tejero-Delgado, R Puerta-Louro, R Rabuñal-Rey
OBJECTIVES: To analyse the influence of epidemiological and sociodemographic factors in complicated alcohol withdrawal syndrome (AWS). MATERIAL AND METHODS: A multicentre, observational prospective study was conducted on consecutively added patients with AWS hospitalised in internal medicine departments. We recorded sociodemographic, epidemiological, clinical and progression data. Complicated AWS was defined as that which progressed with seizures or delirium tremens...
June 20, 2017: Revista Clínica Española
https://www.readbyqxmd.com/read/28637401/relationship-between-ambulatory-arterial-stiffness-index-aasi-and-night-day-blood-pressure-ratio-in-essential-hypertensives
#13
Domenico Di Raimondo, Alessandra Casuccio, Rosangela Di Liberti, Gaia Musiari, Valentina Zappulla, Alessandra D'angelo, Antonio Pinto
BACKGROUND: Ambulatory Arterial Stiffness Index (AASI) has been proposed as an indirect and simpler method to estimate the Arterial Stiffness (AS). AASI, calculated from a set of data collected during a 24-hours ambulatory blood pressure monitoring (ABPM), is defined as 1 minus the regression slope of diastolic on systolic blood pressure (BP) values. For a given increase in diastolic BP, the increase in systolic BP is smaller in a compliant compared to a stiff artery; the stiffer the arterial tree, the closer AASI is to 1...
June 21, 2017: Current Hypertension Reviews
https://www.readbyqxmd.com/read/28627194/s%C3%A3-ndrome-metab%C3%A3-lico-y-riesgo-cardiovascular-en-la-poblaci%C3%A3-n-diab%C3%A3-tica-de-el-hierro-islas-canarias
#14
M Candelaria Martín-González, Ana María Torres-Vega, Emilio González-Reimers, Geraldine Quintero-Platt, Camino Fernández-Rodríguez, Julio Alvisa-Negrín, Adnan Hawari-Meilud, Francisco Santolaria-Fernández
Introducción: en Canarias existe una elevada prevalencia de factores de riesgo vascular, superior a la del resto de España.Objetivo: analizar las características clínicas de 300 adultos diabéticos tipo II de El Hierro, en el Archipiélago Canario.Métodos: los pacientes fueron valorados en la Unidad de Medicina Interna del hospital entre 1982 a 2010, y seguidos hasta diciembre de 2014 o hasta su fallecimiento. La muestra se compone de 154 mujeres y 156 hombres (52%).Resultados: la edad media fue de 66...
June 5, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28609986/a-new-groundwater-dwelling-species-of-i-euryrhynchina-i-from-cameroon%C3%A2-malacostraca-decapoda-euryrhynchidae
#15
Sammy DE Grave, Christophe Piscart, Raoul P Tuekam Kayo, Arthur Anker
A new species of the euryrhynchid shrimp genus Euryrhynchina Powell, 1976, E. puteola sp. nov., is described from Cameroon. The new species can be easily distinguished from the only other species in the genus, E. edingtonae Powell, 1976, by the absence of a setiferous lobe on the eye peduncle, the absence of a meral spine on the ambulatory pereiopods, the shape of the scaphocerite tooth, a single spine on the uropodal diaeresis (vs. 2-3), the absence of a podobranch on the second maxilliped, and the absence of appendices internae on the male pleopods 2-5...
April 12, 2017: Zootaxa
https://www.readbyqxmd.com/read/28604158/a-stepwise-approach-decreasing-infection-in-deep-brain-stimulation-for-childhood-dystonic-cerebral-palsy
#16
Stephen J Johans, Kevin N Swong, Ryan C Hofler, Douglas E Anderson
Dystonia is a movement disorder characterized by involuntary muscle contractions, which cause twisting movements or abnormal postures. Deep brain stimulation has been used to improve the quality of life for secondary dystonia caused by cerebral palsy. Despite being a viable treatment option for childhood dystonic cerebral palsy, deep brain stimulation is associated with a high rate of infection in children. The authors present a small series of patients with dystonic cerebral palsy who underwent a stepwise approach for bilateral globus pallidus interna deep brain stimulation placement in order to decrease the rate of infection...
January 1, 2017: Journal of Child Neurology
https://www.readbyqxmd.com/read/28601681/mutation-of-angiopoietin-1-gene-associates-with-a-new-type-of-hereditary-angioedema
#17
Valeria Bafunno, Davide Firinu, Maria D'Apolito, Giorgia Cordisco, Stefania Loffredo, Angelica Leccese, Maria Bova, Maria Pina Barca, Rosa Santacroce, Marco Cicardi, Stefano Del Giacco, Maurizio Margaglione
BACKGROUND: Hereditary angioedema (HAE) is a rare genetic disease usually due to mutation within the C1 inhibitor or the coagulation Factor XII gene. However, in a series of patients with HAE no causative variants have been described and the pathophysiology of the disease remains unknown (U-HAE). Identification of causative genes in U-HAE is valuable for understanding the cause of the disease. OBJECTIVE: We conducted genetic studies in Italian patients with U-HAE to identify novel causative genes...
June 7, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28591303/translation-and-cross-cultural-adaptation-of-the-clinical-competence-questionnaire-for-use-in-brazil
#18
Danielle Ritter Kwiatkoski, Maria de Fátima Mantovani, Evani Marques Pereira, Carina Bortolato-Major, Ângela Taís Mattei, Aida Maris Peres
Objective: translating and transculturally adapting the Clinical Competence Questionnaire to Brazilian senior undergraduate Nursing students, as well as measuring psychometric properties of the questionnaire. Method: a methodological study carried out in six steps: translation of the Clinical Competence Questionnaire instrument, consensus of the translations, back-translation, analysis by an expert committee, pre-testing and then presentation of the cross-cultural adaptation process to the developers...
June 5, 2017: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/28589693/antipsychotic-prescription-and-mortality-in-hospitalized-older-persons
#19
Deborah Chiesa, Alessandra Marengoni, Alessandro Nobili, Mauro Tettamanti, Luca Pasina, Carlotta Franchi, Codjo D Djade, Salvatore Corrao, Francesco Salerno, Maura Marcucci, Giuseppe Romanelli, Pier Mannuccio Mannucci
BACKGROUND: Recent scientific reports have shown that older persons treated with antipsychotics for dementia-related behavioural symptoms have increased mortality. However, the impact of these drugs prescribed during hospitalization has rarely been assessed. We aimed to investigate whether antipsychotics are associated with an increased risk of mortality during hospitalization and at 3-month follow-up in elderly inpatients. METHODS: We analyzed data gathered during two waves (2010 and 2012) by the REPOSI (Registro Politerapie Società Italiana Medicina Interna)...
June 6, 2017: Psychogeriatrics: the Official Journal of the Japanese Psychogeriatric Society
https://www.readbyqxmd.com/read/28588484/akrinor-tm-a-cafedrine-theodrenaline-mixture-20-1-increases-force-of-contraction-of-human-atrial-myocardium-but-does-not-constrict-internal-mammary-artery-in-vitro
#20
Benjamin Kloth, Simon Pecha, Eileen Moritz, Yvonne Schneeberger, Klaus-Dieter Söhren, Edzard Schwedhelm, Hermann Reichenspurner, Thomas Eschenhagen, Rainer H Böger, Torsten Christ, Sebastian N Stehr
Background: Intraoperative hypotension is a common problem and direct or indirect sympathomimetic drugs are frequently needed to stabilize blood pressure. Akrinor(TM) consists of the direct and the indirect sympathomimetic noradrenaline and norephedrine. Both substances are covalently bound to the phosphodiesterase (PDE) inhibitor theophylline, yielding theodrenaline and cafedrine, respectively. We investigated pharmacodynamic effects of Akrinor(TM) and its constituents on contractile force and tension in human atrial trabeculae and internal A...
2017: Frontiers in Pharmacology
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