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Oral cavity carcinoma

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https://www.readbyqxmd.com/read/29909897/ajcc-8th-edition-oral-cavity-squamous-cell-carcinoma-staging-is-it-an-improvement-on-the-ajcc-7th-edition
#1
Katherine Pollaers, Anton Hinton-Bayre, Peter L Friedland, Camile S Farah
OBJECTIVES: To explore the prognostic and discriminatory ability of the AJCC 8th Edition Oral Cavity cancer staging in a non-North American population, and compare it to the previously used AJCC 7th Edition. MATERIALS AND METHODS: Retrospective chart review was performed at a tertiary referral Otolaryngology, Head Neck and Skull Base Department in Australia, from June 2002 to June 2017. Oral cavity squamous cell carcinoma cases were staged according to AJCC 8th Edition, which was compared to AJCC 7th Edition staging, for disease-free survival (DFS) and overall survival (OS)...
July 2018: Oral Oncology
https://www.readbyqxmd.com/read/29909896/sentinel-node-biopsy-in-early-oral-squamous-cell-carcinomas-long-term-follow-up-and-nodal-failure-analysis
#2
A Moya-Plana, A Aupérin, J Guerlain, P Gorphe, O Casiraghi, G Mamelle, A Melkane, J Lumbroso, F Janot, S Temam
OBJECTIVES: Evaluate the reliability of sentinel node biopsy (SNB) in T1/T2 cN0 oral squamous cell carcinoma (OSCC), and compare recurrence-free time (RFT) and overall survival (OS) between patients undergoing SNB and neck dissection (ND). PATIENTS AND METHODS: Patients with T1/T2 cN0 OSCC underwent SNB followed by systematic ND in the first cohort and SNB followed by selective ND in case of positive sentinel nodes (SN) in the second cohort. RESULTS: A total of 229 patients were followed (first cohort 50, second cohort 179)...
July 2018: Oral Oncology
https://www.readbyqxmd.com/read/29905028/adjuvant-radiotherapy-after-curative-surgery-for-oral-cavity-squamous-cell-carcinoma-and-treatment-effect-of-timing-and-duration-on-outcome-a-taiwan-cancer-registry-national-database-analysis
#3
Yung-Jen Cheng, Mu-Hung Tsai, Chun-Ju Chiang, Sen-Tien Tsai, Tsang-Wu Liu, Pei-Jen Lou, Chun-Ta Liao, Jin-Ching Lin, Joseph Tung-Chieh Chang, Ming-Hsui Tsai, Pen-Yuan Chu, Yi-Shing Leu, Kuo-Yang Tsai, Shyuang-Der Terng, Chih-Yen Chien, Muh-Hwa Yang, Sheng-Po Hao, Chuan-Cheng Wang, Ming-Hsun Tsai, Helen H W Chen, Chin Kuo, Yuan-Hua Wu
Conduct an accurate risk assessment of resected oral cavity squamous cell carcinoma (OSCC) patients by accessing a nationwide systemic investigation is pivotal to improve treatment outcomes. In this article, we tried to determine the impact of different prognostic factors for OSCC patients who received adjuvant radiotherapy (RT) after curative surgery, using Taiwan's national cancer registry database (TCR). A nationwide, large population-based study was conducted using TCR with patients identified from 2007 to 2015...
June 14, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29903623/immune-checkpoint-mediated-myositis-and-myasthenia-gravis-a-case-report-and-review-of-evaluation-and-management
#4
Kylie H Kang, William Grubb, Komal Sawlani, Michael K Gibson, Christopher J Hoimes, Lisa R Rogers, Pierre Lavertu, Min Yao
BACKGROUND: We present a case of myositis and possible overlapping neuromuscular junction disorder following treatment with nivolumab for recurrent/metastatic head and neck squamous cell carcinoma (HNSCC). METHODS: We report a 75-year-old man with recurrent stage IVA, T1N2cM0 oral cavity HNSCC treated with weight-dosed nivolumab who presented three weeks later with severe fatigue, generalized weakness, and bilateral ptosis. Evaluation demonstrated elevated creatine kinase and myopathic motor units on electromyography, supporting a diagnosis of an underlying muscle disease...
June 5, 2018: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29896402/oral-metastasis-of-renal-cell-carcinoma-mimicking-recurrence-of-excised-malignant-myoepithelioma-a-case-report
#5
Yoshihiro Morita, Takaki Iwagami, Chisato Kawakita, Yukiko Kusuyama, Atsuko Niki-Yonekawa, Nobuo Morita
Following breast and lung cancers, renal cell carcinoma (RCC) is the third most frequent cancer to metastasize to the head and neck region, though such cases are rarely reported. Distinguishing between malignant tumors of salivary gland origin and metastatic RCC is very important. The case of a 75-year-old man with an oral cavity lesion in the left buccal submucosa measuring 40×30 mm that had grown substantially over several weeks is presented. His medical history included left kidney cancer 26 years earlier and a malignant myoepithelioma of the left buccal region 7 years earlier...
July 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29896273/aberrant-dna-methylation-of-the-p16-apc-mgmt-timp3-and-cdh1-gene-promoters-in-tumours-and-the-surgical-margins-of-patients-with-oral-cavity-cancer
#6
Joanna Katarzyna Strzelczyk, Łukasz Krakowczyk, Aleksander Jerzy Owczarek
Oral cavity cancer is a type of head and neck squamous cell carcinoma (HNSCC) and contributes to significant morbidity and mortality each year. An epigenetic pathway of transcriptional inactivation for many genes has been described in various cancers, including HNSCC. For our study, we selected genes for which silencing caused by hypermethylation can promote cancer development. In 75 primary HNSCC tumours and paired surgical margins, we investigated the methylation status of the p16, APC, MGMT, TIMP3 and CDH1 gene promoters by methylation-specific PCR after bisulphite treatment...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29895020/locoregional-control-and-toxicity-in-head-and-neck-carcinoma-patients-following-helical-tomotherapy-delivered-intensity-modulated-radiation-therapy-compared-with-3d-crt-data
#7
REVIEW
Olalla Santa Cruz, Pelagia Tsoutsou, Cyril Castella, Kaouthar Khanfir, Sandro Anchisi, Salim Bouayed, Oscar Matzinger, Mahmut Ozsahin
OBJECTIVES: To assess the feasibility and efficacy of intensity-modulated radiation implemented with helical tomotherapy image-guided with daily megavoltage computed tomography for head and neck cancer. METHODS: Between May 2010 and May 2013, 72 patients were treated with curative intent. The median age was 64 years, with 57% undergoing definitive and 43% postoperative radiotherapy. Primary tumour sites were oral cavity (21%), oropharynx (26%), hypopharynx (20%), larynx (22%), and others (11%)...
June 12, 2018: Oncology
https://www.readbyqxmd.com/read/29893275/evaluation-of-xrcc1-gene-polymorphism-as-a-biomarker-in-head-and-neck-cancer-patients-undergoing-chemoradiation-therapy
#8
Sambit Swarup Nanda, Ajeet Kumar Gandhi, Madhup Rastogi, Rohini Khurana, Rahat Hadi, Kamal Sahni, Surendra Prasad Mishra, Anoop K Srivastava, Madan Lal Brahma Bhatt, Devendra Parmar
PURPOSE: We evaluated the correlation of the x-ray repair cross complementing gene 1 (XRCC1) Arg194Trp polymorphism with clinical outcomes in head and neck squamous cell carcinoma (HNSCC) patients treated with concurrent chemoradiation therapy (CCRT). METHODS AND MATERIALS: In this prospective cohort study, we included 101 patients with HNSCC (oral cavity, pharynx, and larynx) who were aged ≥ 18 years, had stage III to IVB disease, had a Karnofsky Performance Status ≥ 80, and were deemed fit for CCRT...
July 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29887186/head-and-neck-squamous-cell-carcinoma-in-people-living-with-hiv-in-france
#9
A Picard, L Arowas, L Piroth, I Heard, T Ferry
OBJECTIVES: Head and neck squamous cell carcinoma (HNSCC), mainly due to smoking, is one of the leading causes of cancer deaths. However, an increasing number of tumors - especially oropharyngeal cancer - are reported in non-smokers in association with the human papillomavirus (HPV). As HIV-infected individuals are particularly at risk of HPV-related disease, we aimed to describe the burden of HNSCC in this population. METHODS: Retrospective chart review of patients from HIV clinics diagnosed with HNSCC between 2004 and 2014...
June 7, 2018: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/29884415/age-and-localization-dependent-functional-and-psychosocial-impairments-and-health-related-quality-of-life-six-months-after-oscc-therapy
#10
Sabine S Linsen, Nils-Claudius Gellrich, Gertrud Krüskemper
OBJECTIVES: The aim of the current study was to evaluate the functional and psychosocial impacts and changes in overall quality of life (QoL) following oral squamous cell carcinoma (OSCC) therapy in different age groups and in different oral locations. MATERIALS AND METHODS: The study assessed questionnaire responses from patients with OSCC (n = 1319) after 6 months of oncologic therapy, as collected in the DÖSAK Rehab Study. Oncological variables, dental status, sensory, QoL, psychosocial outcomes and coping strategies in younger (45-60 years) and older (61-100 years) patients were assessed for different OSCC locations including the entire oral cavity, maxilla, mandible and others besides the maxilla and mandible...
June 2018: Oral Oncology
https://www.readbyqxmd.com/read/29882109/overexpression-of-nicotinamide-n-methyltransferase-in-hsc-2-oscc-cell-line-effect-on-apoptosis-and-cell-proliferation
#11
Riccardo Seta, Marco Mascitti, Roberto Campagna, Davide Sartini, Stefania Fumarola, Andrea Santarelli, Michele Giuliani, Monia Cecati, Lorenzo Lo Muzio, Monica Emanuelli
OBJECTIVES: Oral squamous cell carcinoma (OSCC) is the most common malignancy of oral cavity. Despite advances in therapeutic approaches, the 5-year survival rate for oral cancer has not improved in the last three decades. Therefore, new molecular targets for early diagnosis and treatment of OSCC are needed. In the present study, we focused on the enzyme nicotinamide N-methyltransferase (NNMT). We have previously shown that enzyme expression is upregulated in OSCC and NNMT knockdown in PE/CA PJ-15 cells significantly decreased cell growth in vitro and tumorigenicity in vivo...
June 7, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29880533/microrna-related-genetic-variants-associated-with-overall-survival-of-head-and-neck-squamous-cell-carcinoma
#12
Owen M Wilkins, Alexander J Titus, Lucas A Salas, Jiang Gui, Melissa Eliot, Rondi A Butler, Erich M Sturgis, Guojun Li, Karl T Kelsey, Brock C Christensen
Head and neck squamous cell carcinoma (HNSCC) is commonly diagnosed at an advanced stage and prognosis for such patients is poor. There remains a gap in our understanding of genetic variants related with HNSCC prognosis. MicroRNA-related single nucleotide polymorphisms (miR-SNPs) are a class of genetic variants with gene regulatory potential. We used a genome-scale approach and independent patient populations in a two-stage approach to test 40,286 common miR-SNPs for association with HNSCC survival in the discovery population (n = 847), and selected the strongest associations for replication in validation phase cases (n = 1236)...
June 7, 2018: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/29878161/prognostic-role-of-p16-in-nonoropharyngeal-head-and-neck-cancer
#13
Alex K Bryant, Elena J Sojourner, Lucas K Vitzthum, Kaveh Zakeri, Hanjie Shen, Cammie Nguyen, James D Murphy, Joseph A Califano, Ezra E W Cohen, Loren K Mell
Background: Previous studies have reported conflicting information regarding the prognostic role of p16 in nonoropharyngeal head and neck squamous cell carcinoma (HNSCC). Methods: Using the US Veterans Affairs database, we analyzed 1448 patients with locoregionally advanced HNSCC and known p16 status diagnosed between 2005 and 2015 and treated with surgery, radiotherapy, or chemoradiotherapy. Tumor p16 status was determined through manual review of pathology reports of primary tumor specimens...
June 5, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29877977/multidisciplinary-diagnostic-and-surgical-management-of-adenocarcinoma-gingival-metastases
#14
Dario Di Stasio, Marco Montella, Immacolata Cozzolino, Marco Cicciù, Gabriele Cervino, Renato Silvio Paparella, Rosario Serpico, Luigi Laino
Colon cancer is the third leading cause of cancer-related mortality worldwide and colon cancer metastases in rare sites, such as the oral cavity, lead to a worse prognosis. Oral metastasis is a rare clinical condition and it represents only the 1% among all oral cavity neoplasms. A multidisciplinary approach is recommended to carry out a correct diagnostic procedure that allows distinguishing between metastatic and primitive lesions of the oral cavity. Quick diagnosis and management are fundamental to take an appropriate action as early as possible, as usually the prognosis in patients with oral metastases of colon carcinoma is poor...
June 5, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29872911/can-mr-textural-analysis-improve-the-prediction-of-extracapsular-nodal-spread-in-patients-with-oral-cavity-cancer
#15
Russell Frood, Ebrahim Palkhi, Mark Barnfield, Robin Prestwich, Sriram Vaidyanathan, Andrew Scarsbrook
OBJECTIVE: To explore the utility of MR texture analysis (MRTA) for detection of nodal extracapsular spread (ECS) in oral cavity squamous cell carcinoma (SCC). METHODS: 115 patients with oral cavity SCC treated with surgery and adjuvant (chemo)radiotherapy were identified retrospectively. First-order texture parameters (entropy, skewness and kurtosis) were extracted from tumour and nodal regions of interest (ROIs) using proprietary software (TexRAD). Nodal MR features associated with ECS (flare sign, irregular capsular contour; local infiltration; nodal necrosis) were reviewed and agreed in consensus by two experienced radiologists...
June 5, 2018: European Radiology
https://www.readbyqxmd.com/read/29872648/reconstruction-of-cheek-mucosal-defect-with-a-buccal-fat-pad-flap-in-a-squamous-cell-carcinoma-patient-a-case-report-and-literature-review
#16
Dae-Seok Hwang, Jinyoung Park, Uk-Kyu Kim, Hae-Ryoun Park, Gyoo-Cheon Kim, Mi-Heon Ryu
Background: Squamous cell carcinoma (SCC) is the most commonly occurring malignant tumor in the oral cavity. In South Korea, it occurs most frequently in the mandible, tongue, maxilla, buccal mucosa, other areas of the oral cavity, and lips. Radial forearm free flap (RFFF) is the most widely used reconstruction method for the buccal mucosal defect. The scar of the forearm donor, however, is highly visible and unsightly, and a secondary surgical site is needed when such technique is applied...
December 2018: Maxillofacial Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29871820/impact-of-hpv-associated-p16-expression-and-other-clinical-factors-on-therapeutic-decision-making-in-patients-with-oropharyngeal-cancer-a-gettec-multicentric-study
#17
Dorian Culié, Renaud Garrel, Julien Viotti, Renaud Schiappa, Emmanuel Chamorey, Nicolas Fakhry, Benjamin Lallemant, Sébastien Vergez, Agnès Dupret-Bories, Olivier Dassonville, Gilles Poissonnet, José Santini, Frédéric Peyrade, Karen Benezery, Anne Sudaka, Florence Jourdan-Soulier, Françoise Chapel, Bruno Guelfucci, Alexandre Bozec
OBJECTIVES: To analyze the impact of tumor p16 status and other clinical factors on the therapeutic decision-making process in patients with oropharyngeal squamous cell carcinoma (OPSCC). METHODS: We conducted a multicenter retrospective study (GETTEC collaborative study group) enrolling all OPSCC patients with a determined p16-status considered eligible for surgery between 2009 and 2014. The impact of p16-status and other clinical factors on the therapeutic decision was evaluated in multivariate analysis...
May 25, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29868164/oral-shedding-of-human-herpesviruses-in-patients-undergoing-radiotherapy-chemotherapy-for-head-and-neck-squamous-cell-carcinoma-is-not-affected-by-xerostomia
#18
Michelle Palmieri, Mariana Ornaghi, Victor Adriano de Oliveira Martins, Luciana Correa, Thais Bianca Brandao, Ana Carolina do Prado Ribeiro, Laura Masami Sumita, Tania Regina Tozetto-Mendoza, Claudio Sergio Pannuti, Paulo Henrique Braz-Silva
Background : Xerostomia is a very relevant and frequent complication of radiotherapy, causing the irradiated oral mucosa to be affected by bacterial, fungal and viral infections. Objective : The objective of this study was to evaluate a possible relationship between oral shedding of human herpesviruses and xerostomia in patients with squamous cell carcinoma of head and neck submitted to radio/chemotherapy. Methods : In this study, oral rinse samples were collected weekly from 20 patients during radiotherapy...
2018: Journal of Oral Microbiology
https://www.readbyqxmd.com/read/29865982/malignant-transformation-of-a-canine-papillomavirus-type-1-induced-persistent-oral-papilloma-in-a-3-year-old-dog
#19
Adriana Margarita Regalado Ibarra, Loïc Legendre, John S Munday
This case report describes a rare case of a persistent canine papillomavirus type 1 (CPV-1)-induced oral papilloma that underwent malignant transformation into an oral squamous cell carcinoma (OSCC) in a 3-year-old Labrador retriever cross. Initially, the patient had multiple and multifocal verrucous lesions populating the oral cavity exclusively. The papillomas persisted despite multiple surgical ablations, azithromycin, interferon α-2b, alternative medicines, and off-label drug use of an immunostimulant...
June 2018: Journal of Veterinary Dentistry
https://www.readbyqxmd.com/read/29859041/differences-in-lc3b-expression-and-prognostic-implications-in-oropharyngeal-and-oral-cavity-squamous-cell-carcinoma-patients
#20
Kenneth Lai, Slade Matthews, James S Wilmott, Murray C Killingsworth, Jim L Yong, Nicole J Caixeiro, James Wykes, Allan Samakeh, Dion Forstner, Mark Lee, John McGuinness, Navin Niles, Angela Hong, Ardalan Ebrahimi, Cheok Soon Lee
BACKGROUND: This study examined the prognostic significance of microtubule-associated protein light chain 3B (LC3B) expression in oropharyngeal and oral cavity squamous cell carcinoma (SCC). The prognostic significance of LC3B expression in relation to human papillomavirus (HPV) status in oropharyngeal SCC was also examined. METHODS: Tissue microarrays (TMAs) were constructed from formalin-fixed, paraffin-embedded oropharyngeal (n = 47) and oral cavity (n = 95) SCC tissue blocks from patients with long-term recurrence and overall survival data (median = 47 months)...
June 1, 2018: BMC Cancer
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