keyword
MENU ▼
Read by QxMD icon Read
search

Oral cavity carcinoma

keyword
https://www.readbyqxmd.com/read/29675970/does-hypoxia-inducible-factor-1-%C3%AE-hif-1-%C3%AE-c1772t-polymorphism-predict-short-term-prognosis-in-patients-with-oral-squamous-cell-carcinoma-oscc
#1
Jitender Prasad, Binita Goswami, Srinivas H Gowda, Nikhil Gupta, Shilpa Kumar, Kiran Agarwal, Pravesh Mehra, Bindiya K Pahuja, Anju Chauhan
BACKGROUND: Oral squamous cell carcinoma (OSCC) is a cancer of the oral cavity that is a major health problem in India. There is an urgent need to identify biomarkers that have prognostic significance. We studied HIF1 α levels as well as single nucleotide polymorphism of HIF1α gene in cancer and healthy controls. METHODS: Fifty newly diagnosed OSCC patients and 50 age and sex matched healthy control were included in the study. Serum concentrations of HIF1 α were measured by sandwich ELISA; whereas HIF1 α gene polymorphism study was done using restriction enzyme digestion by HpH I...
April 20, 2018: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/29675646/validation-of-the-8th-edition-of-the-ajcc-uicc-tnm-staging-system-for-tongue-squamous-cell-carcinoma
#2
Satoshi Kano, Tomohiro Sakashita, Nayuta Tsushima, Takatsugu Mizumachi, Akira Nakazono, Takayoshi Suzuki, Shinichiro Yasukawa, Akihiro Homma
BACKGROUND: The revised 8th edition of the AJCC/UICC staging system was released in January 2017, and depth of invasion (DOI) was added to the new criteria for T classification in oral cavity cancer. In this study, we evaluated whether the 8th edition presents the prognosis and risk of nodal metastasis in patients with squamous cell carcinoma of tongue more accurately than did the 7th edition. METHODS: The data for 112 patients were obtained and reclassified based on the criteria presented in the 8th edition...
April 19, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29675295/combination-of-structural-and-vascular-optical-coherence-tomography-for-differentiating-oral-lesions-of-mice-in-different-carcinogenesis-stages
#3
Ping-Hisen Chen, Chien-Hsien Wu, Yi-Fen Chen, Yi-Chen Yeh, Bo-Han Lin, Kuo-Wei Chang, Pei-Yu Lai, Ming-Chih Hou, Ching-Liang Lu, Wen-Chuan Kuo
Differentiating between early malignancy and benign lesions in oral cavities is difficult using current optical tools. As has been shown in previous studies, microvascular changes in squamous epithelium can be regarded as a key marker for diagnosis. We propose the combination of structural and vascular optical coherence tomography (OCT) imaging for the investigation of disease related changes. Progressive thickness changes of epithelium and the destruction of underlying lamina propria was observed during cancer development in a 4- nitroquinoline-1-oxide (4NQO) mouse model...
April 1, 2018: Biomedical Optics Express
https://www.readbyqxmd.com/read/29673737/epidemiological-features-of-cancers-of-the-oral-cavity-oropharynx-hypopharynx-and-larynx-cancer-in-r%C3%A3-union-island
#4
A Delagranda, G Leterme, E Chirpaz, C Ferdynus, C Fernandez, F Rubin
INTRODUCTION: This study had two objectives: firstly, to identify and compare characteristics of cancer of the oral cavity, oropharynx, hypopharynx and larynx in Réunion Island, a tropical French overseas territory in the southern hemisphere; and secondly, to discuss how incidence of these cancers is presented in the international literature. MATERIAL AND METHOD: A retrospective study included 599 patients diagnosed with cancer of the oral cavity, oropharynx, hypopharynx or larynx between 2009 and 2013 in Réunion Island...
April 16, 2018: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/29671054/survivin-expression-in-head-and-neck-squamous-cell-carcinomas-is-frequent-and-correlates-with-clinical-parameters-and-treatment-outcomes
#5
Adrian Münscher, Sebastian Prochnow, Amit Gulati, Guido Sauter, Balazs Lörincz, Marco Blessmann, Henning Hanken, Arne Böttcher, Till Sebastian Clauditz
OBJECTIVES: Strong expression of survivin is associated with worse survival in many different tumours, and in cell culture, a correlation between radiation resistance and survivin expression can be seen. The potential of survivin expression as a prognostic/predictive marker or therapeutic target has not been examined in head and neck squamous cell carcinomas (HNSCC) yet. MATERIAL AND METHODS: Retrospective study of 452 tissue samples and clinical data from patients with squamous cell carcinomas of the larynx/hypopharynx (LSCC), oral cavity (OSCC) and oropharynx (OPSCC) treated in the University Medical Centre Hamburg-Eppendorf between 2002 and 2006...
April 18, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29670856/cdkn2a-copy-number-loss-is-an-independent-prognostic-factor-in-hpv-negative-head-and-neck-squamous-cell-carcinoma
#6
William S Chen, Ranjit S Bindra, Allen Mo, Thomas Hayman, Zain Husain, Joseph N Contessa, Stephen G Gaffney, Jeffrey P Townsend, James B Yu
Background: HPV infection is associated with high p16 expression and good prognosis in head and neck squamous cell carcinomas (HNSCCs). Analysis of CDKN2A, the gene encoding p16, may further elucidate the association between p16 expression and prognosis. We sought to determine whether CDKN2A copy number loss was associated with poor survival in HPV-negative HNSCCs. Methods: The Cancer Genome Atlas HNSCC clinical and genomic data were obtained and integrated. Patients <80 years old with a primary tumor in the oral cavity, oropharynx, hypopharynx, or larynx were included...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29665326/towards-developing-a-meaningful-grading-system-for-cervical-squamous-cell-carcinoma
#7
W Glenn McCluggage
Cervical cancer is one of the commonest cancers worldwide, especially in developing countries. In early stage disease, a variety of pathological parameters are of prognostic value but currently this does not include tumour grade which, for a number of reasons, is of limited or no value in cervical squamous cell carcinomas. In a recent article in this journal, Jesinghaus and colleagues investigated a novel histopathological grading system based on tumour budding and cell nest size, which has been shown to outperform conventional grading systems for squamous cell carcinoma at several other sites such as lung, oral cavity, and oesophagus in terms of patient prognostication...
April 2018: Journal of Pathology. Clinical Research
https://www.readbyqxmd.com/read/29664694/immediate-use-of-uncuffed-tracheostomy-after-free-flap-reconstruction-of-the-head-and-neck
#8
Priyesh N Patel, Al C Valmadrid, Daniel Y Hong, David O Francis, Michael W Sim, Sarah L Rohde
Objective To determine if immediate postoperative uncuffed tracheostomy placement following oral cavity or oropharyngeal head and neck free flap reconstruction is associated with shorter hospital length of stay and higher inpatient decannulation rates without an increase in respiratory complications, as compared with immediate placement of cuffed tracheostomy. Study Design Retrospective cohort. Setting Tertiary referral center. Subjects and Methods Patients were included if they underwent free flap reconstruction for oral cavity or oropharyngeal squamous cell carcinoma and had an intraoperative tracheostomy placed between 2005 and 2016...
April 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29663347/a-tgf-%C3%AE-1-genetic-variant-at-the-mirna187-binding-site-significantly-modifies-risk-of-hpv16-associated-oropharyngeal-cancer
#9
Ye Tao, Erich M Sturgis, Zhigang Huang, Yan Sun, Kristina R Dahlstrom, Qingyi Wei, Guojun Li
TGF-β1rs1982073 polymorphism at the miRNA-187 binding site may alter TGF-β1 expression and function, and thereby this polymorphism (genotype CT/CC) increases cancer susceptibility. HPV16 L1 seropositivity is associated with the risk of oral squamous cell carcinoma (OSCC), including oropharyngeal squamous cell carcinoma (OPSCC) and oral cavity squamous cell carcinoma (OCSCC). Thus, we hypothesized that TGF-β1rs1982073 polymorphism at the miRNA-187 binding site combined with HPV16 L1 seropositivity may have a joint effect on OSCC susceptibility...
April 16, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29658104/comparison-of-the-seventh-and-eighth-edition-american-joint-committee-on-cancer-oral-cavity-staging-systems
#10
John D Cramer, Abhita Reddy, Robert L Ferris, Umamaheswar Duvvuri, Sandeep Samant
OBJECTIVE: For the first time in 30 years, the eighth edition of the American Joint Committee on Cancer (AJCC) Staging Manual offers major changes in the staging of oral cavity cancer. We evaluated the predictive ability of the new staging system for oral cavity cancer to validate these changes and hypothesized that the new system would improve prognostic accuracy. METHODS: We conducted a retrospective cohort study of patients with oral cavity squamous cell carcinoma in the National Cancer Data Base from 2009 to 2013 and applied the seventh and eighth edition staging AJCC staging systems to all patients...
April 15, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29652009/immunohistochemical-expression-of-polo-like-kinase-1-in-oral-squamous-cell-carcinoma-and-oral-submucous-fibrosis
#11
Kavitha Vittal, Sathasivasubramanian Sankara Pandian, Leena Dennis Joseph, Shilpa Germaine Raj
Context: Polo-like kinase 1 (PLK1) is a critical molecule in the proliferation of several human cancers. Overexpression of PLK1 has been correlated with cancer cell proliferation and lower overall survival rates. Although PLK1 has been studied in various tumors, information regarding its expression in oral cancer and precancer is limited. Aims: This study is aimed at evaluating the expression of PLK1 in a potentially malignant and malignant disorder of the oral cavity, namely, oral submucous fibrosis (OSMF) and oral squamous cell carcinoma (OSCC), respectively, using the immunohistochemistry technique...
March 2018: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/29651934/effects-of-curcumin-on-squamous-cell-carcinoma-of-tongue-an-in-vitro-study
#12
Lorenzo Lo Muzio, Fatima Ardito
BACKGROUND: The squamous cell carcinoma of the tongue (TSCC) is the most frequent cancer of oral cavity often characterized by poor prognosis. Conventional therapies are not very efficient and often may cause serious side effects. In this contest, introduction of natural substances as possible adjuvant in the treatment and prevention of cancer is becoming a relevant topic. In fact, curcumin has been used for decades in Chinese traditional medicine for its beneficial effects. Curcumin has anti-cancer properties in many tumors however, its action on the tongue carcinoma is not entirely clear and many other investigations are necessary...
April 12, 2018: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/29645080/risk-of-oral-tongue-cancer-among-immunocompromised-transplant-recipients-and-human-immunodeficiency-virus-infected-individuals-in-the-united-states
#13
Joseph E Tota, Eric A Engels, Margaret M Madeleine, Christina A Clarke, Charles F Lynch, Ana P Ortiz, Brenda Y Hernandez, Anil K Chaturvedi
BACKGROUND: Oral tongue cancer incidence has increased among whites in the United States; however, the cause remains unknown. If an infectious agent is implicated, then elevated risk would be expected among immunosuppressed individuals. METHODS: By using population-based registry linkage information from the US Transplant Cancer Match and human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) Cancer Match studies, the authors examined the risk of oral tongue squamous cell carcinoma (SCC) among immunocompromised transplantation recipients and HIV-infected individuals...
April 12, 2018: Cancer
https://www.readbyqxmd.com/read/29642408/mucormycosis-battle-with-the-deadly-enemy-over-a-five-year-period-in-india
#14
Jagdish Chander, Mandeep Kaur, Nidhi Singla, R P S Punia, Surinder K Singhal, Ashok K Attri, Ana Alastruey-Izquierdo, Alberto M Stchigel, Jose F Cano-Lira, Josep Guarro
Mucormycosis is an emerging opportunistic fungal infection. Increasing immunocompromization, widespread use of antibacterial and antifungal agents (such as voriconazole prophylaxis), carcinomas, transplantation and lifestyle diseases such as diabetes are the main contributors to this situation. The predominant clinical manifestations of mucormycosis vary from host to host, with rhino-orbital-cerebral, pulmonary, cutaneous, and gastrointestinal infections being the most common. In India, the prevalence of mucormycosis is approximately 0...
April 6, 2018: Journal of Fungi (Basel, Switzerland)
https://www.readbyqxmd.com/read/29628167/clinicopathological-features-of-squamous-cell-carcinoma-of-the-oral-cavity-and-oropharynx-in-young-patients
#15
R C-P Martinez, H P Sathasivam, B Cosway, V Paleri, S Fellows, J Adams, M Kennedy, R Pearson, A Long, P Sloan, M Robinson
Our aim was to examine the clinicopathological features of squamous cell carcinoma (SCC) of the oral cavity and oropharynx in a group of young patients who were dignosed during a 15-year period (2000-2014). Patients' clinical details, risk factors, and survival were obtained from medical records. Formalin-fixed, paraffin-embedded, tissue was tested for high-risk human papillomavirus (HPV). The results were compared with those of a matching group of older patients. We identified 91 patients who were younger than 45 years old, and the 50 youngest patients were studied in detail...
April 5, 2018: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/29622120/imaging-of-minor-salivary-glands
#16
REVIEW
Ahmed Abdel Khalek Abdel Razek, Suresh K Mukherji
Neoplastic and non-neoplastic lesions may involve the minor salivary glands. Tumors of minor salivary glands are commonly seen in the oral cavity. Malignant tumors are more common than benign minor salivary gland tumors. The most common malignant tumors are adenoid cystic carcinoma and mucoepidermoid carcinoma, and the most common benign tumor is pleomorphic adenoma. Non-neoplastic lesions may involve minor salivary glands such as Sjogrene disease, immunoglobulin G4-related disease, necrotizing sialometaplasia, and subacute necrotizing sialadenitis...
May 2018: Neuroimaging Clinics of North America
https://www.readbyqxmd.com/read/29619101/frequency-of-cervical-nodal-metastasis-in-early-stage-squamous-cell-carcinoma-of-the-tongue
#17
Sadaf Qadeer Ahmed, Montasir Junaid, Sohail Awan, Maliha Kazi, Hareem Usman Khan, Sohail Halim
Introduction  Oral cavity carcinoma is an aggressive tumor, with the tongue being one of the most common subsites of involvement. Surgery is a gold standard method of dealing with advanced-stage tumors. However, for early-stage carcinomas of the tongue, the management remains controversial. Several studies have indicated that early-stage cancers have a high chance of occult cervical node metastasis, which, if left untreated, can greatly affect the prognosis. Certain parameters can help identify patients with occult cervical node metastases, and can avoid unnecessary neck dissection in node negative patients...
April 2018: International Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/29616906/diagnostic-pathway-of-oral-cavity-cancer-in-an-integrated-health-care-system
#18
Kevin H Wang, Brian H Song, Jason E Gilde, Jeanne A Darbinian, Miranda L Ritterman Weintraub, Tara J Wu, Eleanor L Yang, James W Salazar, Deepak Gurushanthaiah
CONTEXT: Survival for patients with oral cavity squamous cell carcinoma (OCSCC) has remained relatively stagnant despite advances in treatment. Few studies have examined why advanced-stage disease is diagnosed in 40% of patients with OCSCC nationally. OBJECTIVE: To characterize the diagnostic pathway of OCSCC in an integrated health care system. DESIGN: Retrospective study of patients with OCSCC (2007-2010). MAIN OUTCOME MEASURES: Referral patterns and demographic, clinical, and tumor characteristics associated with time to diagnosis (diagnostic interval)...
March 30, 2018: Permanente Journal
https://www.readbyqxmd.com/read/29605084/evaluation-of-bone-resection-margins-of-segmental-mandibulectomy-for-oral-squamous-cell-carcinoma
#19
R W H Smits, Ivo Ten Hove, E A C Dronkers, T C Bakker Schut, H Mast, R J Baatenburg de Jong, E B Wolvius, G J Puppels, S Koljenović
Resection margins are frequently studied in patients with oral squamous cell carcinoma and are accepted as a constant prognostic factor. While most evidence is based on soft tissue margins, reported data for bone resection margins are scarce. The aim of this retrospective study was to evaluate and determine the utility of surgical margins in bone resections for oral cavity squamous cell carcinoma (OCSCC). The status of bone resection margins and their impact on survival was investigated in patients who had undergone segmental mandibulectomy for OCSCC...
March 28, 2018: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29604745/a-monolithic-microsphere-fiber-probe-for-spatially-resolved-raman-spectroscopy-application-to-head-and-neck-squamous-cell-carcinomas
#20
S Holler, B Haig, M J Donovan, M Sobrero, B A Miles
The ability to identify precise cancer margins in vivo during a surgical excision is critical to the well-being of the patient. Decreased operative time has been linked to shorter patient recovery time, and there are risks associated with removing either too much or too little tissue from the surgical site. The more rapidly and accurately a surgeon can identify and excise diseased tissue, the better the prognosis for the patient. To this end, we investigate both malignant and healthy oral cavity tissue using the Raman spectroscopy, with a monolithic microsphere-fiber probe...
March 2018: Review of Scientific Instruments
keyword
keyword
104000
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"