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https://www.readbyqxmd.com/read/29452770/single-arm-phase-2-trial-of-elective-nodal-dose-reduction-for-patients-with-locoregionally-advanced-squamous-cell-carcinoma-of-the-head-and-neck
#1
Patrick D Maguire, Charles R Neal, Stuart M Hardy, Andrew M Schreiber
PURPOSE: To evaluate a novel chemoradiation therapy (CRT) regimen for patients with squamous cell carcinoma of the head and neck (SCCHN) incorporating a lower intensity modulated radiation therapy dose to electively treated neck lymph nodes than is currently standard. METHODS AND MATERIALS: Eligible patients had locally advanced SCCHN of the oral cavity, oropharynx, larynx, or hypopharynx. The 7-week CRT course consisted of weekly cisplatin at 35 mg/m 2 concurrently with sequential-boost intensity modulated radiation therapy: 36 Gy to high- and low-risk planning target volumes followed by a sequential boost to the high-risk planning target volume to 70 Gy...
December 28, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29447885/pediatric-head-and-neck-squamous-cell-carcinoma-patient-demographics-treatment-trends-and-outcomes
#2
Ankit Modh, Omar H Gayar, Mohamed A Elshaikh, Arnold C Paulino, Farzan Siddiqui
OBJECTIVES: To examine patient demographics, temporal and treatment trends, and survival outcomes of pediatric non-nasopharyngeal head and neck squamous cell carcinomas using the National Cancer Database. METHODS: The National Cancer Database was queried for pediatric patients (age 0-19 years) diagnosed with squamous cell carcinoma of the head and neck (including oral cavity, oropharynx, nasal cavity, larynx, hypopharynx, and salivary glands) from 2004 to 2013. RESULTS: Of 159 patients identified, the majority had oral cavity SCC (55%)...
March 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29445878/feasibility-of-intraoperative-detection-of-sentinel-lymph-nodes-with-89-zirconium-labelled-nanocolloidal-albumin-pet-ct-and-a-handheld-high-energy-gamma-probe
#3
Derrek A Heuveling, K Hakki Karagozoglu, Arthur Van Lingen, Otto S Hoekstra, Guus A M S Van Dongen, Remco De Bree
BACKGROUND: PET/CT lymphoscintigraphy using 89 Zr-nanocolloidal albumin has the potential to improve the preoperative identification of sentinel lymph nodes (SLNs), especially if located in the near proximity of the primary tumour. This study aims to demonstrate the feasibility of PET/CT lymphoscintigraphy followed by intraoperative detection of 89 Zr-nanocolloidal albumin containing SLNs with the use of a handheld high-energy gamma probe. METHODS: PET/CT lymphoscintigraphy was performed after peritumoural injection of 89 Zr-nanocolloidal albumin in five patients with oral cavity carcinoma planned for surgical resection...
February 14, 2018: EJNMMI Research
https://www.readbyqxmd.com/read/29443777/oral-leukoplakia-a-precancerous-lesion-of-squamous-cell-carcinoma-in-patients-with-long-term-pegylated-liposomal-doxorubicin-treatment
#4
Hidetaka Nomura, Kimihiko Sakamoto, Takeru Sugihara, Shuhei Okamoto, Yoichi Aoki, Terumi Tanigawa, Maki Matoda, Kohei Omatsu, Hiroyuki Kanao, Kazuyoshi Kato, Kuniko Utsugi, Yuko Sugiyama, Nobuhiro Takeshima
Pegylated liposomal doxorubicin (PLD) has a good safety profile, but long-term use has been associated with development of squamous cell carcinoma of the tongue and oral cavity (SCCTO) in some patients. The study objective was to estimate the prevalence of oral leukoplakia, a known precursor of SCCTO, in patients with ovarian cancer and long-term PLD use.After approval of the institutional review board, medical record of 114 patients who were treated with PLD at our institution between January 2010 and December 2016 were retrospectively reviewed...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29433990/follow-up-after-curative-treatment-for-oral-squamous-cell-carcinoma-a-critical-appraisal-of-the-guidelines-and-a-review-of-the-literature
#5
REVIEW
M T Brands, P A Brennan, A L M Verbeek, M A W Merkx, S M E Geurts
The oral cavity is the commonest subsite of head and neck squamous cell carcinoma (HNSCC). Because of the rising incidence and increasing survival, more patients will be enrolled in a routine follow-up program. This review gives an overview of the evidence and guideline recommendations concerning follow-up after oral squamous cell carcinoma (OSCC). There is limited evidence concerning the effectiveness of follow-up after OSCC. This lack of evidence is reflected in a variation in guideline recommendations with respect to test interval and duration (i...
January 12, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29428867/raman-spectroscopy-for-assessment-of-bone-resection-margins-in-mandibulectomy-for-oral-cavity-squamous-cell-carcinoma
#6
Elisa M Barroso, Ivo Ten Hove, Tom C Bakker Schut, Hetty Mast, Cornelia G F van Lanschot, Roeland W H Smits, Peter J Caspers, Rob Verdijk, Vincent Noordhoek Hegt, Robert J Baatenburg de Jong, Eppo B Wolvius, Gerwin J Puppels, Senada Koljenović
OBJECTIVES: The aim of this study was to investigate the potential of Raman spectroscopy for detection of oral cavity squamous cell carcinoma (OCSCC) in bone resection surfaces during mandibulectomy. MATERIALS & METHODS: Raman mapping experiments were performed on fresh mandible resection specimens from patients treated with mandibulectomy for OCSCC. A tumour detection algorithm was created based on water concentration and the high-wavenumber range (2800 cm-1-3050 cm-1) of the Raman spectra...
February 8, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29427129/trends-in-human-papillomavirus-related-oropharyngeal-squamous-cell-carcinoma-incidence-vermont-1999-2013
#7
Adepitan A Owosho, Rashidah Wiley, Tessie Stansbury, Semiu O Gbadamosi, Jon S Ryder
This study examines trends in age-adjusted incidence rates of human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC) in comparison to oral cavity proper squamous cell carcinoma (OSCC) in the population of Vermont from 1999 to 2013. Data on cases of oral and pharynx cancers diagnosed in Vermont between 1999 and 2013 were obtained from the Vermont cancer registry. The age-adjusted incidence rates and annual percentage change of HPV-related OPSCC and OSCC were calculated using Joinpoint trend analysis...
February 9, 2018: Journal of Community Health
https://www.readbyqxmd.com/read/29423108/cancer-immunogenomic-approach-to-neoantigen-discovery-in-a-checkpoint-blockade-responsive-murine-model-of-oral-cavity-squamous-cell-carcinoma
#8
Paul Zolkind, Dariusz Przybylski, Nemanja Marjanovic, Lan Nguyen, Tianxiang Lin, Tanner Johanns, Anton Alexandrov, Liye Zhou, Clint T Allen, Alexander P Miceli, Robert D Schreiber, Maxim Artyomov, Gavin P Dunn, Ravindra Uppaluri
Head and neck squamous cell carcinomas (HNSCC) are an ideal immunotherapy target due to their high mutation burden and frequent infiltration with lymphocytes. Preclinical models to investigate targeted and combination therapies as well as defining biomarkers to guide treatment represent an important need in the field. Immunogenomics approaches have illuminated the role of mutation-derived tumor neoantigens as potential biomarkers of response to checkpoint blockade as well as representing therapeutic vaccines...
January 9, 2018: Oncotarget
https://www.readbyqxmd.com/read/29423024/a-novel-multiplex-detection-array-revealed-systemic-complement-activation-in-oral-squamous-cell-carcinoma
#9
Juliane Gallenkamp, Gerrit Spanier, Elisabeth Wörle, Markus Englbrecht, Michael Kirschfink, Roman Greslechner, Regine Braun, Nicole Schäfer, Richard J Bauer, Diana Pauly
Oral squamous cell carcinoma (OSCC) is one of the most common tumors within the oral cavity. Early diagnosis and prognosis tools are urgently needed. This study aimed to investigate the activation of the complement system in OSCC patients as potential biomarker. Therefore, an innovative complement activation array was developed. Characterized antibodies detecting the complement activation specific epitopes C3a, C5a and sC5b-9 along with control antibodies were implemented into a suspension bead array. Human serum from a healthy (n = 46) and OSCC patient (n = 57) cohort were used to investigate the role of complement activation in oral tumor progression...
January 9, 2018: Oncotarget
https://www.readbyqxmd.com/read/29415020/the-evolution-of-the-epidemiological-landscape-of-head-and-neck-cancer-in-italy-is-there-evidence-for-an-increase-in-the-incidence-of-potentially-hpv-related-carcinomas
#10
Paolo Boscolo-Rizzo, Manuel Zorzi, Annarosa Del Mistro, Maria Cristina Da Mosto, Giancarlo Tirelli, Carlotta Buzzoni, Massimo Rugge, Jerry Polesel, Stefano Guzzinati
The current study aimed to investigate the incidence and survival patterns of HNSCCs arising from different anatomic sites, potentially related (the oropharynx) or unrelated (the oral cavity, the larynx/hypopharynx) to HPV, to provide clues on possible growing impact of HPV in the epidemiology of HNSCC in Italy. Epidemiological data were retrieved from ten long-term Cancer Registries covering a population of 7.8 million inhabitants. Trends were described by means of the estimated annual percent change (APC) stratified by age and gender, and compared between HPV-related and HPV-unrelated anatomical sites...
2018: PloS One
https://www.readbyqxmd.com/read/29413278/multicenter-study-of-carbon-ion-radiation-therapy-for-adenoid-cystic-carcinoma-of-the-head-and-neck-subanalysis-of-the-japan-carbon-ion-radiation-oncology-study-group-j-cros-study-1402-hn
#11
Nor Shazrina Sulaiman, Yusuke Demizu, Masashi Koto, Jun-Ichi Saitoh, Hiroaki Suefuji, Hiroshi Tsuji, Tatsuya Ohno, Yoshiyuki Shioyama, Tomoaki Okimoto, Takashi Daimon, Kenji Nemoto, Takashi Nakano, Tadashi Kamada
PURPOSE: To retrospectively analyze the treatment outcomes of carbon-ion radiation therapy for adenoid cystic carcinoma (ACC) of the head and neck at 4 active carbon-ion facilities in Japan. METHODS AND MATERIALS: A total of 289 patients who underwent carbon-ion radiation therapy for histology-proven ACC of the head and neck at 4 institutions in Japan between November 2003 and December 2014 were included in this study. RESULTS: Median patient age was 58 years (range, 12-83 years)...
March 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29411723/diagnostic-role-of-neutrophil-lymphocyte-ratio-in-oral-cavity-cancers
#12
M D Zl, R Karamert, H Tutar, M Şahin, A Türkcan, M Yılmaz
AIM: In this study, we aimed to evaluate the diagnostic role of neutrophil-lymphocyte ratio (NLR) and other hemogram parameters in differentiating nonmalignant oral cavity lesions from oral cavity cancers. METHODS: Ninety-five patients who were performed oral cavity biopsy between the years 2013 and 2015 were retrospectively reviewed. The control group comprised consecutive 70 patients who underwent septoplasty/septorhinoplasty procedures. Inclusion criteria were to be available with common blood count (CBC) just prior to procedure...
January 2018: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29411154/modified-biweekly-cisplatin-docetaxel-plus-cetuximab-tpex-as-first-line-treatment-for-patients-with-recurrent-metastatic-head-and-neck-cancer
#13
Hannah Fuchs, Johannes Pammer, Christoph Minichsdorfer, Doris Posch, Gabriela Kornek, Marie-Bernadette Aretin, Thorsten Fuereder
Three weekly high-dose chemotherapy regimens in combination with weekly cetuximab are the treatment of choice for patients with recurrent/metastatic (R/M) head and neck squamous cell carcinoma (SCCHN), although the majority of patients suffer from severe side effects. Thus, we investigated the efficacy and safety of an alternative, more convenient and less toxic biweekly modified cisplatin, docetaxel plus cetuximab (TPEx) regimen in this retrospective analysis. Thirty-eight patients receiving off-protocol cisplatin (50 mg/m2) in combination with docetaxel (50 mg/m2) plus cetuximab (500 mg/m2) every other week were included...
February 7, 2018: Medical Oncology
https://www.readbyqxmd.com/read/29408977/phase-ii-trial-of-combination-treatment-with-paclitaxel-carboplatin-and-cetuximab-pce-as-first-line-treatment-in-patients-with-recurrent-and-or-metastatic-squamous-cell-carcinoma-of-the-head-and-neck-cspor-hn02
#14
M Tahara, N Kiyota, T Yokota, Y Hasegawa, K Muro, S Takahashi, T Onoe, A Homma, J Taguchi, M Suzuki, K Minato, K Yane, S Ueda, H Hara, K Saijo, T Yamanaka
Background: The standard of care for first-line treatment of recurrent and/or metastatic squamous cell carcinoma of the head and neck (R/M SCCHN) is combination treatment with platinum, 5-FU and cetuximab (PFE). However, this regimen requires hospitalization to ensure proper hydration and continuous infusion of 5-FU, and causes severe nausea and anorexia. We evaluated the efficacy and safety of paclitaxel, carboplatin and cetuximab (PCE) as first-line treatment in patients with R/M SCCHN...
February 2, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29408295/kir2ds1-2ds5-3ds1-and-kir2dl5-are-associated-with-the-risk-of-head-and-neck-squamous-cell-carcinoma-in-iranians
#15
Shaghik Barani, Bijan Khademi, Elham Ashouri, Abbas Ghaderi
BACKGROUND: Activatingandinhibitory KIRreceptors (aKIR, iKIR) control the development and function of NK cells whose function alterations adjust the tumor microenvironment immunity. This research was conducted to determine the KIRs gene impact on genetic predisposition to Head and Neck Squamous Cell Carcinoma (HNSCC) in Iranians. METHODS: KIR genotyping usingsequence-specific primers-polymerase chain reaction (SSP-PCR) method was performed to identify the presence of all 16 KIRgenes in 285 HNSCC patients, including laryngeal, oral cavity and pharyngeal SCC and 273 controls (CNs)...
February 2, 2018: Human Immunology
https://www.readbyqxmd.com/read/29407234/pathogenic-features-of-streptococcus-mutans-isolated-from-dental-prosthesis-patients-and-diagnosed-cancer-patients-with-dental-prosthesis
#16
Sultan Ali S Alanazi, Khalid Tawfik Alduaiji A, Bharathraj Shetty, Hamad Awadh Alrashedi, B L Guruprasanna Acharya, Sajith Vellappally, Darshan Devang Divakar
Though S. mutans, virulence, and pathogenesis are characterized reports are limited to the status of its carriage and virulence in patients with oral cancer and prosthesis. In this present study, we investigated the pathogenic characteristics of twenty strains of S. mutans of healthy subjects, fifteen of prosthesis patients, and eleven from oral cancer. The putative virulence gene and other factors, such as the ability to adhere to the oral epithelial cells, production of glycan and lactic acid of these strains were examined as...
January 30, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29406335/fish-shellfish-intake-and-the-risk-of-head-and-neck-cancer
#17
Kathleen M McClain, Patrick T Bradshaw, Nikhil K Khankari, Marilie D Gammon, Andrew F Olshan
Fish intake and other dietary sources of omega-3 fatty acids have been shown to be associated with a reduced risk for some cancers. Although previous studies of head and neck cancer have reported associations with different dietary factors, including reduced risks for fruits and vegetables and putatively healthy dietary patterns, associations specific to fish intake are unclear. This study investigated the association between fish/shellfish intake and risk of squamous cell carcinoma of the head and neck (SCCHN) using data from the Carolina Head and Neck Cancer Epidemiology Study, a population-based case-control study conducted in 46 North Carolina counties with cases recruited from 2002 through 2006...
February 5, 2018: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/29404898/induction-chemotherapy-with-the-extreme-regimen-in-frail-patients-with-locally-advanced-head-and-neck-squamous-cell-carcinoma
#18
Valérie Cochin, Erwan de Mones, Laurence Digue, Muriel Garcia-Ramirez, Charles Dupin, Claire Majoufre, Philipe Fernandez, Amaury Daste
BACKGROUND: Induction chemotherapy (IC) with TPF (docetaxel, cisplatin, 5FU) for locally advanced head and neck squamous cell carcinoma (LAHNSCC) is limited to fit patients. OBJECTIVE: We conducted a retrospective cohort study to assess the use of the EXTREME regimen (platinum-based therapy, 5FU, cetuximab) as IC in frail patients with LAHNSCC. PATIENTS AND METHODS: Retrospective analysis of all consecutive patients with unresectable LAHNSCC treated with the EXTREME regimen, with or without 5FU as IC, from two French centers from 2008 to 2015...
February 5, 2018: Targeted Oncology
https://www.readbyqxmd.com/read/29403311/radiation-induced-secondary-malignancies-for-nasopharyngeal-carcinoma-a-pilot-study-of-patients-treated-via-imrt-or-vmat
#19
Hsiao-Fei Lee, Jen-Hong Lan, Pei-Ju Chao, Hui-Min Ting, Hui-Chun Chen, Hsuan-Chih Hsu, Tsair-Fwu Lee
Background: Patients treated with radiotherapy are at risk of developing a second cancer during their lifetime, which can directly impact treatment decision-making and patient management. The aim of this study was to qualify and compare the secondary cancer risk (SCR) after intensity-modulated radiation therapy (IMRT) and volumetric-modulated arc therapy (VMAT) in nasopharyngeal carcinoma (NPC) patients. Patients and methods: We analyzed the treatment plans of a cohort of 10 NPC patients originally treated with IMRT or VMAT...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29402786/rigid-triple-endoscopy-improves-clinical-staging-of-primary-head-and-neck-cancer
#20
Shachi J Sharma, Jens J Linke, Tobias Kroll, Nora Wuerdemann, Jens P Klussmann, Orlando Guntinas-Lichius, Claus Wittekindt
BACKGROUND: Correct pre-therapeutic staging of the first primary carcinoma (FPC) and detection of simultaneous second primary carcinomas (SSPCs) decisively influence therapy and prognosis of head and neck squamous cell carcinomas (HNSCC). The aim of this study was to determine the benefit of pre-therapeutic triple endoscopy for detection of SSPC and pre-therapeutic T category. METHODS: A cohort of 234 HNSCC patients with completed triple endoscopy was reviewed, focusing on pre-therapeutic T category and SSPC...
2018: Oncology Research and Treatment
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