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https://www.readbyqxmd.com/read/29039600/synergism-between-%C3%AE-mangostin-and-trail-induces-apoptosis-in-squamous-cell-carcinoma-of-the-oral-cavity-through-the-mitochondrial-pathway
#1
Masakatsu Fukuda, Hide Sakashita, Hiroyasu Hayashi, Junya Shiono, Genki Miyake, Yusuke Komine, Fuyoko Taira, Hideaki Sakashita
Mangosteen (Garcinia mangostana) is a tree found in South-East Asia and the pericarp of its fruit has been used in folk medicine for the treatment of many human illnesses. Mangosteen fruit rinds contain a high concentration of xanthone, which is a type of polyphenol. One type of xanthone, α-mangostin, has been reported to exert chemopreventive effects against chemically-induced colon cancer through the decrease of c-Myc expression, suppressing tumor growth in a mouse model of mammary cancer. A recent study demonstrated the inhibitive effect of α-mangostin on the growth of prostate cancer...
October 12, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29031904/definitive-radiotherapy-for-a-head-and-neck-merkel-cell-carcinoma-and-comprehensive-nodal-volumes-a-case-for-using-a-computer-designed-variable-thickness-compensator-to-reduce-risk-and-severity-of-mucositis
#2
Anesa Ahamad, Donald T Weed, Darel D Pruett, Daniel Saulpaugh, Womah Neeranjun, Eduardo Fernandez
When contemplating how to treat head and neck primary cancers and regional lymph nodes with radiotherapy, we often select the contemporary intensity-modulated radiotherapy (IMRT) without much consideration of older methods that may give fewer side effects and be more cost-effective. For an 87-year-old female with a 1.5-cm Merkel cell carcinoma (MCC) located 1.5 cm lateral to the orbital rim, we were challenged to deliver 50 Gy to comprehensive elective nodal regions and 70 Gy to the primary. We were particularly concerned about the potential adverse acute effects of radiotherapy to mucosal structures in this elderly female...
October 11, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/29026845/osteonecrosis-of-the-jaws-in-patient-received-bisphosphonates-and-sunitinib-separately-a-case-report
#3
Farzaneh Ashrafi, Ali Derakhshandeh, Bijan Movahedian, Azadeh Moghaddas
Recently published reports have suggested that antiangiogenic drugs such as sunitinib could potentiate the osteonecrosis of the jaw (ONJ) induced by bisphosphonates (BPs) and even induce this adverse effect per se. We reported a case of ONJ with renal cell carcinoma under sunitinib medication and history of BPs therapy. A 53-year-old man was referred to the oral surgery clinic complaining of painful exposed oral lesion and bone extraction from right lower jaw in the mouth. He underwent nephrectomy followed by 5 months treatment with cycles of 50 mg sunitinib (Sutent(®)) once a day for 4 weeks followed by 2 weeks drug free before lesion exposure in October 2016...
July 2017: Journal of Research in Pharmacy Practice
https://www.readbyqxmd.com/read/29026519/squamous-cell-carcinoma-arising-in-familial-gingival-fibromatosis-a-rare-case-report
#4
Dilasma Ghartimagar, Ujjwal Koirala, Arnab Ghosh, Manish Kiran Shrestha, Sushma Thapa, Raghavan Narasimhan, O P Talwar
Familial gingival fibromatosis is a rare hereditary condition due to chromosomal abnormality which can occur as an isolated disease or as part of a syndrome and has an incidence of 1:350 000. This condition leads to esthetic, functional, psychological and masticatory disturbance of the oral cavity. Here, we present a case of 21-year-old female with severe enlargement of gums in maxilla and mandible. Deciduous teeth were erupted at normal age but the permanent teeth in the oral cavity were not erupted. Her grandmother, father and younger sister were also affected with the same condition...
October 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29025723/setting-the-stage-for-2018-how-the-changes-in-the-american-joint-committee-on-cancer-union-for-international-cancer-control-cancer-staging-manual-eighth-edition-impact-radiologists
#5
C M Glastonbury, S K Mukherji, B O'Sullivan, W M Lydiatt
The updated eighth edition of the Cancer Staging Manual of the American Joint Committee on Cancer will be implemented in January 2018. There are multiple changes to the head and neck section of the manual, which will be relevant to radiologists participating in multidisciplinary head and neck tumor boards and reading pretreatment head and neck cancer scans. Human papillomavirus-related/p16(+) oropharyngeal squamous cell carcinoma will now be staged separately; this change reflects the markedly better prognosis of these tumors compared with non-human papillomavirus/p16(-) oropharyngeal squamous cell carcinoma...
October 12, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29022097/prevalence-of-fibroblast-growth-factor-receptor-1-fgfr1-amplification-in-squamous-cell-carcinomas-of-the-head-and-neck
#6
Till Sebastian Clauditz, Arne Böttcher, Henning Hanken, Kerstin Borgmann, Guido Sauter, Waldemar Wilczak, Tobias Grob, Adrian Münscher
BACKGROUND: FGFR1 is a receptor tyrosine kinases involved in tumor growth signaling, survival, and differentiation in many solid cancer types. There is growing evidence that FGFR1 amplification might predict therapy response to FGFR1 inhibitors in squamous cell lung cancers. To estimate the potential applicability of anti FGFR1 therapies in squamous cell carcinomas of the head and neck, we studied patterns of FGFR1 amplification using fluorescence in situ hybridization (FISH). MATERIALS AND METHODS: A tissue microarray was constructed from 453 primary treatment-naive squamous cell carcinomas of the head and neck regions with histopathological and clinical follow-up data [including oral cavity (n = 222), oropharynx (n = 126), and larynx (n = 105)]...
October 11, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28988428/risk-factors-for-salvage-surgery-failure-in-oral-cavity-squamous-cell-carcinoma
#7
Danielli Matsuura, Tiago Dias Valim, Marco Aurélio Vamondes Kulcsar, Fábio Roberto Pinto, Lenine Garcia Brandão, Claudio Roberto Cernea, Leandro Luongo Matos
OBJECTIVES/HYPOTHESIS: Locoregional recurrences of oral cavity squamous cell carcinoma (SCC) may be diagnosed during follow-up of surgically treated patients. Nevertheless, few studies have investigated factors that impact salvage surgery failure and the mortality rates of these patients. The objectives were to identify predictive factors of salvage surgery failure and mortality in patients who undergo surgical treatment for recurrent oral cavity SCC and to compare the overall survival rates of these patients with those of patients who undergo only one surgical treatment...
October 8, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28987229/controversies-in-oral-and-maxillofacial-oncology
#8
REVIEW
Jacob G Yetzer
Imaging studies are essential components of tumor diagnosis, staging, assessing tumor response to neoadjuvant and adjuvant therapies, and postoperative surveillance on completion of definitive treatment. Treatment of early stage clinically node negative oral cavity squamous cell carcinoma is controversial. Approximately 3% of all head and neck tumors arise within the parotid gland and most often within the superficial lobe, lateral to the facial nerve; about 80% are benign and most are pleomorphic adenoma. In patients with dry eyes failing multiple other treatment modalities and facing ongoing pain and loss of vision, microvascular transplant of the submandibular gland is a viable option...
November 2017: Oral and Maxillofacial Surgery Clinics of North America
https://www.readbyqxmd.com/read/28981214/nodal-factors-predictive-of-recurrence-and-survival-in-patients-with-oral-cavity-squamous-cell-carcinoma
#9
Ho-Jin Son, Jong-Lyel Roh, Kyung-Ja Cho, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim
OBJECTIVES: Lymph node (LN) metastasis of oral cavity squamous cell carcinoma (OSCC) is associated with survival outcomes. However, the relationship between different metastatic nodal factors and treatment outcomes require further elucidation. This study examined nodal factors predictive of recurrence and survival in patients with OSCC. METHODS: This prospective observational study included 157 patients with OSCC who underwent surgery between 2010 and 2015. Clinicopathological and follow-up information were recorded...
October 5, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28981169/mir-200c-3p-spreads-invasive-capacity-in-human-oral-squamous-cell-carcinoma-microenvironment
#10
Tomoyo Kawakubo-Yasukochi, Masahiko Morioka, Mai Hazekawa, Atsushi Yasukochi, Takuya Nishinakagawa, Kazuhiko Ono, Shintaro Kawano, Seiji Nakamura, Manabu Nakashima
Oral squamous cell carcinoma (OSCC) constitutes over 90% of all cancers in the oral cavity. The prognosis for patients with invasive OSCC is poor; therefore, it is important to understand the molecular mechanisms of invasion and subsequent metastasis not only to prevent cancer progression but also to detect new therapeutic targets against OSCC. Recently, extracellular vesicles-particularly exosomes-have been recognized as intercellular communicators in the tumor microenvironment. As exosomic cargo, deregulated microRNAs (miRNAs) can shape the surrounding microenvironment in a cancer-dependent manner...
October 5, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28979139/cervical-level-iib-metastases-in-squamous-cell-carcinoma-of-the-oral-cavity-a-systematic-review-and-meta-analysis
#11
Yurong Kou, Tengfei Zhao, Shaohui Huang, Jie Liu, Weiyi Duan, Yunjing Wang, Zechen Wang, Delong Li, Chunliu Ning, Changfu Sun
PURPOSE: The aim of this study was to clarify whether level IIb dissection should be performed or avoided in the treatment of oral squamous cell carcinoma by meta-analysis. MATERIALS AND METHODS: Articles that were published before June 2017 were searched electronically in four databases (Web of Science, PubMed, Ovid and China National Knowledge Infrastructure) without any date or language restrictions by two independent reviewers. Abstracts and full-text papers which investigated the cervical metastases to level IIb from primary head and neck cancers and were deemed potentially relevant were screened...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28977897/endoplasmic-reticulum-aminopeptidase-2-involvement-in-metastasis-of-oral-cavity-squamous-cell-carcinoma-discovered-by-proteome-profiling-of-primary-cancer-cells
#12
I-Chun Kuo, Huang-Kai Kao, Yenlin Huang, Chun-I Wang, Jui-Shan Yi, Ying Liang, Chun-Ta Liao, Tzu-Chen Yen, Chih-Ching Wu, Kai-Ping Chang
Oral cavity squamous cell carcinoma (OSCC) is a leading cause of cancer-related deaths worldwide and associated with poor prognosis and mortality. Discovery of proteins that can improve OSCC treatment is needed. Using comparative proteome profiling of primary cells derived from OSCC and adjacent noncancerous epithelium, endoplasmic reticulum aminopeptidases 2 (ERAP2) has been identified as an OSCC-associated protein. Compared with the adjacent normal tissues, ERAP2 levels were determined to be significantly elevated in OSCC tissues using quantitative real-time PCR and immunohistochemistry...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28975663/architectural-patterns-of-p16-immunohistochemical-expression-associated-with-cancer-immunity-and-prognosis-of-head-and-neck-squamous-cell-carcinoma
#13
Hyang Joo Ryu, Eun Kyung Kim, Su Jin Heo, Byoung Chul Cho, Hye Ryun Kim, Sun Och Yoon
We evaluated the expression patterns of p16, which is used as a surrogate marker of HPV infection in head and neck squamous cell carcinoma (HNSCC), in regard to their biological and prognostic implications. p16 expression patterns and infiltrated immune cells were analyzed through immunohistochemistry of p16, CD3, CD8, PD-1, FOXP3, and CD163 on surgically resected HNSCCs (n = 393). Patterns of p16 immunoexpression were defined as STRONG (strong, diffuse expression in cytoplasm, and nucleus in >70% of tumor cells), MARGINAL (expression restricted to tumor margins), MOSAIC (ragged, discontinued expression), NUCLEAR (expression in nuclei only), and ABSENT (no expression)...
October 4, 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/28969885/tumor-pd-l1-expression-is-associated-with-improved-survival-and-lower-recurrence-risk-in-young-women-with-oral-cavity-squamous-cell-carcinoma
#14
G J Hanna, S-B Woo, Y Y Li, J A Barletta, P S Hammerman, J H Lorch
Young patients with oral cavity squamous cell carcinoma (OCSCC) are often recognized as a distinct epidemiological cohort. In this study, genomic and immune-based metrics were correlated with long-term outcomes for a young patient population treated at a single institution. A fully clinically annotated, retrospective cohort of 81 patients aged ≤45 years with OCSCC is described, and the impact of clinicopathological features on long-term survival outcomes is reported. Genomic and immune parameters were integrated utilizing a whole-exome sequencing and immunohistochemical approach among females in the cohort...
September 29, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28969257/role-of-neck-dissection-in-clinical-t3n0m0-lesion-of-oral-cavity-changing-trend
#15
Arjun Dass, Surinder K Singhal, Rps Punia, Nitin Gupta, Hitesh Verma, Shilpi Budhiraja, Minakshi Salaria
INTRODUCTION: Neck dissection is an important part in the management of head and neck malignancies especially in terms of control of nodal metastasis. The study is focused on evaluating the profile of lymph nodes in T3N0M0 lesion of different subsides of oral cavity. AIM: To evaluate the utility of neck dissection in T3N0M0 stage of carcinomas of the different region of oral cavity. MATERIALS AND METHODS: Ninety patients aged 20 to 70 years underwent treatment for carcinoma of the oral cavity at our center between 2005 and 2013...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28958308/evidence-based-clinical-practice-guideline-for-the-evaluation-of-potentially-malignant-disorders-in%C3%A2-the-oral-cavity-a-report-of-the-american-dental-association
#16
Mark W Lingen, Elliot Abt, Nishant Agrawal, Anil K Chaturvedi, Ezra Cohen, Gypsyamber D'Souza, JoAnn Gurenlian, John R Kalmar, Alexander R Kerr, Paul M Lambert, Lauren L Patton, Thomas P Sollecito, Edmond Truelove, Malavika P Tampi, Olivia Urquhart, Laura Banfield, Alonso Carrasco-Labra
BACKGROUND: An expert panel convened by the American Dental Association (ADA) Council on Scientific Affairs and the Center for Evidence-Based Dentistry conducted a systematic review and formulated clinical recommendations to inform primary care clinicians about the potential use of adjuncts as triage tools for the evaluation of lesions, including potentially malignant disorders (PMDs), in the oral cavity. TYPES OF STUDIES REVIEWED: This is an update of the ADA's 2010 recommendations on the early diagnosis of PMDs and oral squamous cell carcinoma...
October 2017: Journal of the American Dental Association
https://www.readbyqxmd.com/read/28955422/human-papillomavirus-in-head-and-neck-squamous-cell-carcinoma-a-descriptive-study-of-histologically-confirmed-cases-at-kamuzu-central-hospital-in-lilongwe-malawi
#17
Claire E Faggons, Charles E Mabedi, N George Liomba, William K Funkhouser, Fred Chimzimu, Coxcilly Kampani, Robert Krysiak, Nelson Msiska, Carol G Shores, Satish Gopal
BACKGROUND: Head and neck squamous cell carcinoma (HNSCC) is common in sub-Saharan Africa, but the aetiologic contribution of human papillomavirus (HPV) is not well established. METHODS: We assessed HNSCC cases for HPV using p16 immunohistochemistry (IHC) in Malawi. Associations between p16 IHC and tumour site, behavioural risk factors, demographic characteristics, and HIV status were examined. RESULTS: From 2010 to 2014, 77 HNSCC cases were identified...
June 2017: Malawi Medical Journal: the Journal of Medical Association of Malawi
https://www.readbyqxmd.com/read/28951751/adjuvant-high-dose-rate-brachytherapy-in-the-management-of-oral-cavity-cancers-5-years-of-experience-in-iran
#18
Ali Kazemian, Mohammad Babaei, Marzieh Lashkari, Reza Ghalehtaki, Ata Garajei, Maziar Motiee-Langroudi, Ahmadreza Sebzari, Ramin Jaberi, Soraya Gholami, Somayyeh Babaloui, Mahdi Aghili
PURPOSE: Brachytherapy is a cost-effective method for the management of oral cavity cancers in low to middle income countries. We aimed to evaluate the clinical outcomes of high-dose-rate interstitial brachytherapy (HDR-IBT) in patients with oral cavity cancer. MATERIAL AND METHODS: From 2009 to 2013, 78 patients (49 combined external beam radiotherapy [EBRT] plus IBT and 29 IBT monotherapy) with oral cavity cancers had been treated in our center. Slightly more than half the patients were male, and the median age was 54 years...
August 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28950305/a-randomized-phase-2-study-of-cetuximab-plus-cisplatin-with-or-without-paclitaxel-for-the-first-line-treatment-of-patients-with-recurrent-and-or-metastatic-squamous-cell-carcinoma-of-the-head-and-neck
#19
P Bossi, R Miceli, L D Locati, D Ferrari, S Vecchio, G Moretti, N Denaro, F Caponigro, C Moro, E Vaccher, A Sponghini, A Caldara, G Rinaldi, F Ferrau, F Nolè, S Lo Vullo, F Tettamanzi, L Hollander, L Licitra
Background: B490 (EudraCT# 2011-002564-24) is a randomized, phase 2b, noninferiority study investigating the efficacy and safety of first-line cetuximab plus cisplatin with/without paclitaxel (CetCis versus CetCisPac) in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck (R/M SCCHN). Patients and methods: Eligible patients had confirmed R/M SCCHN (oral cavity/oropharynx/larynx/hypopharynx/paranasal sinus) and no prior therapy for R/M disease...
September 8, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28948509/beyond-the-percentages-of-pd-l1-positive-tumor-cells-induced-versus-constitutive-pd-l1-expression-in-primary-and-metastatic-head-and-neck-squamous-cell-carcinoma
#20
Theresa Scognamiglio, Yao-Tseng Chen
Anti-PD1 antibody has been approved for metastatic squamous cell carcinoma of the head and neck (SCCHN) and objective response rates of approximately 20% have been reported. Defining PD-L1 expression at ≥ 1% tumor cells as positive, PD-L1-positive tumors showed a higher response rate. However, it is unclear whether 1% is the optimal cutoff, and studies on lung cancer suggested 50% cutoff as a stronger predictive biomarker. 96 primary SCCHN from oropharynx and oral cavity and 34 corresponding metastatic lesions were typed for membranous PD-L1 expression...
September 25, 2017: Head and Neck Pathology
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