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Oral cavity carcinoma

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https://www.readbyqxmd.com/read/29233054/pretreatment-serum-lactate-dehydrogenase-as-a-prognostic-indicator-for-oral-cavity-squamous-cell-carcinoma
#1
Yukinori Takenaka, Ryohei Oya, Kengo Aoki, Hiroko Hamaguchi, Kazuya Takemura, Masayuki Nozawa, Takahiro Kitamura, Yoshifumi Yamamoto, Atsuhiko Uno
OBJECTIVES: To examine whether lactate dehydrogenase (LDH) can predict the prognosis of oral cavity squamous cell carcinoma (OSCC) and to determine the optimal cut-off values for LDH. METHODS: This retrospective study included 184 patients with OSCC, treated with surgery between 2006 and 2014. The association between LDH and T, N classification was investigated using the Mann-Whitney test. Cut-off values for LDH were determined with a recursive partitioning analysis (RPA)...
December 12, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29232177/metformin-effects-on-metabolic-coupling-and-tumor-growth-in-oral-cavity-squamous-cell-carcinoma-coinjection-xenografts
#2
Patrick Tassone, Marina Domingo-Vidal, Diana Whitaker-Menezes, Zhao Lin, Megan Roche, Madalina Tuluc, Ubaldo Martinez-Outschoorn, Joseph Curry
Objective Many aggressive head and neck cancers contain 2 metabolically coupled tumor compartments: a glycolytic stromal compartment with low caveolin-1 (CAV1) and high monocarboxylate transporter 4 (MCT4) expression and a highly proliferative carcinoma cell compartment with high MCT1. Metabolites are shuttled by MCTs from stroma to carcinoma to fuel tumor growth. We studied the effect of carcinoma-fibroblast coinjection and metformin administration on a mouse model of head and neck squamous cell carcinoma...
December 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29226639/early-diagnosis-of-oral-squamous-cell-carcinoma-by-salivary-micrornas
#3
REVIEW
Raluca Dumache
BACKGROUND: Oral squamous cell carcinoma (OSCC), the most common type of oral cancer, and represents more than 90% of malignancies of the oral cavity. Worldwide, each year about 275,000 are newly diagnosed. If detected at an early stage, OSCC has a survival rate of up to 80% compared to the detection in later stages (T3-T4) when a survival rate of 20 - 30% is present. METHODS: Because OSCC presents these survival rates, there is an urgent need to introduce new non-invasive molecular biomarkers for the early detection of OSCC from saliva, which will contribute to an increased long term survival rate for these patients...
November 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/29224831/reconstruction-of-oral-cavity-defect-using-versatile-buccinator-myomucosal-flaps-in-the-treatment-of-ct2-3-n0-oral-cavity-squamous-cell-carcinoma-feasibility-morbidity-and-functional-oncological-outcomes
#4
Dongbin Ahn, Gil Joon Lee, Jin Ho Sohn
OBJECTIVES: To evaluate the results of oral cavity reconstruction using various types of buccinator myomucosal flap (BMMF) for the treatment of cT2-3 oral cavity squamous cell carcinoma (OCSCC). MATERIALS AND METHODS: Twenty-two consecutive patients who underwent surgical management for OCSCC and reconstruction using various types of BMMF were enrolled. Surgical results, complications, speech/swallowing outcomes, and recurrence were evaluated. RESULTS: The mean flap harvest time was 28...
December 2017: Oral Oncology
https://www.readbyqxmd.com/read/29224815/definitive-chemo-radiotherapy-is-a-curative-alternative-for-standard-of-care-in-advanced-stage-squamous-cell-carcinoma-of-the-oral-cavity
#5
Joris B W Elbers, Abrahim Al-Mamgani, Danique Paping, Michiel W M van den Brekel, Katarzyna Jóźwiak, J P de Boer, Baris Karakullukcu, Marcel Verheij, Charlotte L Zuur
OBJECTIVE: To compare outcome after definitive (chemo)radiotherapy (CRT group) with standard of care (surgery group) for advanced stage oral cavity carcinoma (OCC). Although definitive (chemo)radiotherapy is assumed to be inferior to surgery with regard to disease control, data on outcome of this approach are scarce. METHODS: Retrospective analysis by chart review (2000-2013). Endpoints were locoregional control (LRC), disease-free survival (DFS), disease specific survival (DSS) and overall survival (OS)...
December 2017: Oral Oncology
https://www.readbyqxmd.com/read/29208932/mouse-papillomavirus-infection-persists-in-mucosal-tissues-of-an-immunocompetent-mouse-strain-and-progresses-to-cancer
#6
Nancy M Cladel, Lynn R Budgeon, Karla K Balogh, Timothy K Cooper, Sarah A Brendle, Neil D Christensen, Todd D Schell, Jiafen Hu
Mouse papillomavirus has shown broad tissue tropism in nude mice. Previous studies have tested cutaneous infections in different immunocompromised and immunocompetent mouse strains. In the current study, we examined mucosal infection in several immunocompetent and immunocompromised mouse strains. Viral DNA was monitored periodically by Q-PCR of lavage samples. Immunohistochemistry and in situ hybridization were used to determine viral capsid protein and viral DNA respectively. All athymic nude mouse strains showed active infections at both cutaneous and mucosal sites...
December 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29206324/ahns-series-do-you-know-your-guidelines-evidence-based-management-of-oral-cavity-cancers
#7
Amarbir Gill, Nilesh Vasan, Babak Givi, Arjun Joshi
Oral cavity squamous cell carcinoma (OCSCC) is the most common nonmelanoma head and neck cancer in the world, with an estimated 405 000 new cases expected each year. Subsites of the oral cavity include the alveolar ridge, buccal mucosa, anterior tongue, tonsillar pillar, retromolar trigone, hard palate, gingiva, and floor of the mouth. In this issue of the AHNS "Do you know your guidelines?" series, we review the evidence-based approach to the management of oral cavity carcinomas based on the framework provided by the National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines in Oncology...
December 5, 2017: Head & Neck
https://www.readbyqxmd.com/read/29204919/prognostic-value-of-the-lymph-node-ratio-in-oropharyngeal-carcinoma-stratified-for-hpv-status
#8
Christian Jacobi, Josepha Rauch, Jan Hagemann, Thomas Lautz, Maximilian Reiter, Philipp Baumeister
OBJECTIVE: Lymph node ratio (LNR) was shown to be a prognostic factor in laryngeal and oral cavity primaries. The purpose of this study was to investigate the impact of the lymph node ratio in oropharyngeal squamous cell carcinoma (OPSCC) with a high incidence of HPV-related disease. Therefore, the role of LNR was evaluated as an additional predictive parameter to the 8th edition of AJCC TNM staging system. METHODS: From December 2009 to August 2015, patients diagnosed with primary oropharyngeal squamous cell carcinoma were prospectively enrolled...
December 4, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29201965/salivary-chemical-factors-in-relation-with-oral-cancer-in-smokers-and-non-smokers-a-literature-review
#9
REVIEW
Tahereh Nosratzehi
Squamous cell carcinoma of oral cavity is of malignant tumors, which causes cancerous complications. DNA damage, mainly because of products of oxidative stress like reactive oxygen species, is a frequent mutagenic that triggers carcinoma. Smoking increases the probability of cancer incidence. Saliva is the first biological medium to interact with external compounds, especially smoking substances. The present study overviews the salivary level of some remarkable compounds in relation with smoking and squamous cell carcinoma...
December 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/29199654/impact-of-induction-chemotherapy-to-concurrent-chemoirradiation-over-radiotherapy-alone-in-advanced-oral-cavity
#10
M S Rewadkar, V K Mahobia
BACKGROUND: Oral and oropharyngeal carcinomas representing about 90% of all oral malignancies are the sixth most common cancers worldwide. Basic modalities of cancer treatment are surgery, radiotherapy, and chemotherapy (CT) either alone or in combination. For squamous cell carcinoma (SCC) patients, induction CT followed by radiotherapy and concurrent CT are effective methods for improving response rates. MATERIALS AND METHODS: Fifty patients with advance stage oral cavity cancer with performance status >60% on Karnofsky performance scale and having no prior exposure to CT, radiotherapy, and surgery were included in the study...
January 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29195664/-actinomycosis-revealed-by-ulceration-of-the-palate-and-gingiva
#11
F Dessirier, J-P Arnault, J Denamps, H Sevestre, C Attencourt, C Lok
BACKGROUND: Actinomycosis is a chronic and extensive granulomatous, bacterial infection. Revelation by oral ulceration is rare. PATIENTS AND METHODS: A 76-year-old patient with diabetes was treated with dabrafenib for stage IV melanoma. A follow-up visit revealed two ulcerated, infiltrated and hyperalgesic lesions of the palate and gingiva. There were no associated signs. The laboratory findings were normal. The possibility of squamous cell carcinoma occurring with BRAF inhibitors was discussed, despite the rarity of such cases in the literature...
November 28, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29184122/bacterial-alterations-in-salivary-microbiota-and-their-association-in-oral-cancer
#12
Wei-Hsiang Lee, Hui-Mei Chen, Shun-Fa Yang, Chao Liang, Chih-Yu Peng, Feng-Mao Lin, Lo-Lin Tsai, Buor-Chang Wu, Chung-Han Hsin, Chun-Yi Chuang, Ting Yang, Tzu-Ling Yang, Shinn-Ying Ho, Wen-Liang Chen, Kwo-Chang Ueng, Hsien-Da Huang, Chien-Ning Huang, Yuh-Jyh Jong
Oral squamous cell carcinoma (OSCC) is the most common malignant neoplasm of the oral cavity and the fourth leading malignancy and cause of cancer-related death in the male population of Taiwan. Most cases are detected at advanced stages, resulting in poor prognosis. Therefore, improved detection of early oral health disorders is indispensable. The involvement of oral bacteria in inflammation and their association with OSCC progression provide a feasible target for diagnosis. Due to the nature of oral neoplasms, the diagnosis of epithelial precursor lesions is relatively easy compared with that of other types of cancer...
November 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29183823/lip-reconstruction-tecnique-a-modified-abbe-estlander-with-a-myomucosal-advancement-flap
#13
Philip J Brabyn, Mario Fernando Muñoz-Guerra, Ian Zylberberg, Francisco José Rodríguez-Campo
Lip cancer represents between 12-15% of all oral cavity cancers; 95% affect the lower lip. The main objectives in lip reconstruction after tumoral mass resection are functionality and esthetics. We present the case of an 81-year-old male with a past medical history of squamous cell carcinoma of the maxilla. The patient consults with the Maxillofacial Surgery Department due to a hypertrophic lesion in the left oral commissure. The defect is considered intermediate in size (between 50% and 2/3). For reconstruction of the lip, a classical rotation flap (Estlander flap) is used together with a myomucosal flap, which is both innervated and expandable...
November 25, 2017: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29183025/can-early-dissection-of-cervical-lymph-nodes-improve-prognosis-in-squamous-cell-carcinomas-of-the-hard-palate
#14
Sophie Deneuve, Anne-Gaelle Bodard, Erica Delquignies, François Janot, Philippe Zrounba, Morbize Julieron
Squamous cell carcinomas of the hard palate and maxillary alveolar ridge are rare tumours with a poor prognosis. Lymph node dissection is recommended for tumours with nodal involvement, and is rarely performed in the absence of adenopathy. We report a series of patients with squamous cell carcinomas and evaluate the rate of lymph node invasion and its impact on survival. This is a retrospective study of 72 patients treated for squamous cell carcinoma of the hard palate and maxillary alveolar ridge between January 1, 1998 and December 31, 2008 in two cancer centres...
November 29, 2017: ORL; Journal for Oto-rhino-laryngology and its related Specialties
https://www.readbyqxmd.com/read/29181079/survivin-expression-hpv-positivity-and-microvessel-density-in-oropharyngeal-carcinomas-and-relationship-with-survival-time
#15
Ebru Tastekin, Vuslat Yurut Caloglu, Nilufer Kilic Durankus, Necdet Sut, Gorkem Turkkan, Nuray Can, Fulya Oz Puyan, Murat Caloglu
Introduction: Among head and neck cancers, those of the oral cavity and oropharynx are the second most prevalent following the larynx. This study aimed to research immunohistochemical expression of survivin, HPV positivity and microvessel density in tumors and their relationships with prognosis. Material and methods: Pathological materials and demographic properties of 46 patients were retrospectively evaluated. Survivin, HPV and CD34 (for microvessel density evaluation) antibodies were applied tumoral tissues...
October 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29180076/delineation-of-the-primary-tumour-clinical-target-volumes-ctv-p-in-laryngeal-hypopharyngeal-oropharyngeal-and-oral-cavity-squamous-cell-carcinoma-airo-caca-dahanca-eortc-georcc-gortec-hknpcsg-hncig-iag-kht-lprhht-ncic-ctg-ncri-nrg-oncology-phns-sbrt-somera
#16
Vincent Grégoire, Mererid Evans, Quynh-Thu Le, Jean Bourhis, Volker Budach, Amy Chen, Abraham Eisbruch, Mei Feng, Jordi Giralt, Tejpal Gupta, Marc Hamoir, Juliana K Helito, Chaosu Hu, Keith Hunter, Jorgen Johansen, Johannes Kaanders, Sarbani Ghosh Laskar, Anne Lee, Philippe Maingon, Antti Mäkitie, Francesco Micciche', Piero Nicolai, Brian O'Sullivan, Adela Poitevin, Sandro Porceddu, Krzysztof Składowski, Silke Tribius, John Waldron, Joseph Wee, Min Yao, Sue S Yom, Frank Zimmermann, Cai Grau
PURPOSE: Few studies have reported large inter-observer variations in target volume selection and delineation in patients treated with radiotherapy for head and neck squamous cell carcinoma. Consensus guidelines have been published for the neck nodes (see Grégoire et al., 2003, 2014), but such recommendations are lacking for primary tumour delineation. For the latter, two main schools of thoughts are prevailing, one based on geometric expansion of the Gross Tumour Volume (GTV) as promoted by DAHANCA, and the other one based on anatomical expansion of the GTV using compartmentalization of head and neck anatomy...
November 24, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29178331/response-to-bullous-pemphigoid-inguinalis
#17
Anuradha Bishnoi, Tarun Narang, Sanjeev Handa
We appreciate the constructive comments by author Abdelmaksoud in response to our report of bullous pemphigoid (BP) presenting in association with metastatic penile squamous cell carcinoma (SCC). Though our patient had few blisters on the back, upper limbs and oral cavity, the chief brunt of the disease was on the inguinal area. Cases of localized BP, arising after radiotherapy for breast carcinoma have been reported. Our patient developed BP before receiving radiotherapy. This article is protected by copyright...
November 24, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29176703/nsd1-and-nsd2-damaging-mutations-define-a-subset-of-laryngeal-tumors-with-favorable-prognosis
#18
Suraj Peri, Evgeny Izumchenko, Adrian D Schubert, Michael J Slifker, Karen Ruth, Ilya G Serebriiskii, Theresa Guo, Barbara A Burtness, Ranee Mehra, Eric A Ross, David Sidransky, Erica A Golemis
Squamous cell carcinomas of the head and neck (SCCHN) affect anatomical sites including the oral cavity, nasal cavity, pharynx, and larynx. Laryngeal cancers are characterized by high recurrence and poor overall survival, and currently lack robust molecular prognostic biomarkers for treatment stratification. Using an algorithm for integrative clustering that simultaneously assesses gene expression, somatic mutation, copy number variation, and methylation, we for the first time identify laryngeal cancer subtypes with distinct prognostic outcomes, and differing from the non-prognostic laryngeal subclasses reported by The Cancer Genome Atlas (TCGA)...
November 24, 2017: Nature Communications
https://www.readbyqxmd.com/read/29174131/phase-1b-2a-trial-of-the-superoxide-dismutase-mimetic-gc4419-to-reduce-chemoradiotherapy-induced-oral-mucositis-in-patients-with-oral-cavity-or-oropharyngeal-carcinoma
#19
Carryn M Anderson, Stephen T Sonis, Christopher M Lee, Douglas Adkins, Bryan G Allen, Wenqing Sun, Sanjiv S Agarwala, Madhavi L Venigalla, Yuhchyau Chen, Weining Zhen, Diane R Mould, Jon T Holmlund, Jeffrey M Brill, John M Buatti
PURPOSE: To assess the safety of the superoxide dismutase mimetic GC4419 in combination with radiation and concurrent cisplatin for patients with oral cavity or oropharyngeal cancer (OCC) and to assess the potential of GC4419 to reduce severe oral mucositis (OM). PATIENTS AND METHODS: Patients with locally advanced OCC treated with definitive or postoperative intensity modulated radiation therapy (IMRT) plus cisplatin received GC4419 by 60-minute intravenous infusion, ending <60 minutes before IMRT, Monday through Friday for 3 to 7 weeks, in a dose and duration escalation study...
October 16, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29171929/ahns-series-do-you-know-your-guidelines-principles-of-treatment-for-locally-advanced-or-unresectable-head-and-neck-squamous-cell-carcinoma
#20
Cory D Fulcher, Missak Haigentz, Thomas J Ow
This article is a continuation of the "Do You Know Your Guidelines" series, initiated by the Education committee of the American Head and Neck Society. Treatment guidelines for advanced head and neck squamous cell carcinoma are reviewed here, including the critical roles of radiotherapy, chemotherapy, and the recent application of immunotherapy agents. We will be limiting this discussion to include cancers of the oral cavity, oropharynx, hypopharynx, and larynx. It should be noted that much of the article pertains to human papillomavirus (HPV)-negative oropharyngeal cancer where applicable, as HPV-positive oropharyngeal squamous cell carcinoma carries a different natural history, different prognosis, and now different staging criteria...
November 24, 2017: Head & Neck
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