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Morphea

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https://www.readbyqxmd.com/read/29332706/skin-mapping-for-the-classification-of-generalized-morphea
#1
Noelle Teske, Joseph Welser, Heidi Jacobe
BACKGROUND: Generalized morphea lacks cohesive clinical features, limiting its clinical and investigative utility. OBJECTIVE: We sought to use computerized lesion mapping to objectively subtype morphea. METHODS: We conducted a 2-part cross-sectional study. In part 1, we created a discovery cohort of patients with generalized morphea of whom lesion maps were created to characterize subsets. Clinical and demographic features were compared between proposed subsets to determine if they identified clinically relevant differences...
February 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29315793/mood-changes-with-methotrexate-therapy-for-dermatologic-disease
#2
Trisha Bhat, Carrie C Coughlin
Neurotoxicity and cognitive effects of low-dose methotrexate for rheumatologic disease have often been described, but the neuropsychiatric effects of low-dose methotrexate for cutaneous disease have been underreported in the dermatology literature. We describe two children who experienced mood changes with methotrexate treatment for lichen sclerosus with morphea overlap and psoriasis, with rapid resolution of these symptoms after methotrexate cessation. We also detail possible mechanisms underlying psychiatric changes with methotrexate therapy...
January 9, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29258795/esophageal-symptoms-and-their-lack-of-association-with-high-resolution-manometry-in-systemic-sclerosis-patients
#3
Ana Cecilia Arana-Guajardo, Gustavo Barrera-Torres, Miguel Ángel Villarreal-Alarcón, David Vega-Morales, Jorge Antonio Esquivel-Valerio
BACKGROUND: The esophageal involvement in systemic sclerosis (SSc) causes impact in the morbidity and mortality. High resolution manometry assesses esophageal involvement. Our aim was to categorize esophageal motor disorder in patients with SSc by HRM. METHODS: We carried out an observational, descriptive and cross-sectional study. All patients underwent HRM as well as semi-structured interviews to assess frequency and severity of upper GI symptoms. Patients also completed the gastroesophageal reflux questionnaire (Carlsson-Dent)...
December 16, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/29248149/morphea-in-childhood-an-update
#4
B Aranegui, J Jiménez-Reyes
Morphea is an inflammatory, fibrosing skin disorder. When it occurs in childhood, it is also known as localized juvenile scleroderma. It is more common in girls and typically appears around the age of 5 to 7 years. According to a recent classification system, morphea is divided into 5 types: circumscribed (plaque), linear, generalized, pansclerotic, and mixed. Approximately 40% of patients present extracutaneous manifestations. Childhood morphea is treated with phototherapy, oral or topical calcitriol, topical tacrolimus 0...
December 13, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/29246801/transcriptional-and-cytokine-profiles-identify-cxcl9-as-a-biomarker-of-disease-activity-in-morphea
#5
J S Mertens, E M G J de Jong, A Pandit, M M B Seyger, E P A H Hoppenreijs, R M Thurlings, M C Vonk, J Wienke, F van Wijk, A van Royen-Kerkhof, W Marut, T R D Radstake
No abstract text is available yet for this article.
December 12, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29237158/dermoscopy-of-morphea-and-cutaneous-lichen-sclerosus-clinicopathological-correlation-study-and-comparative-analysis
#6
Enzo Errichetti, Aimilios Lallas, Zoe Apalla, Alessandro Di Stefani, Giuseppe Stinco
BACKGROUND: Dermoscopy of morphea and cutaneous lichen sclerosus (CLS) has been described by various studies, with none of them considering variability according to clinical phases and investigating dermoscopic-histological correlations. OBJECTIVE: To evaluate dermoscopic features in general and according to clinical stage, identify possible distinctive dermoscopic clues, and assess dermoscopy accuracy in detecting subclinical alterations in morphea and CLS. METHODS: A representative dermoscopic image of target lesions was evaluated for the presence of specific features, correlating them with clinical subtype (inflammatory, inflammatory-sclerotic, sclerotic, or sclerotic-atrophic)...
December 14, 2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/29234720/radiation-induced-circumscribed-superficial-morphea-after-brachytherapy-for-endometrial-adenocarcinoma
#7
Apoorva Trivedi, Corey M DeWitt, Laura McGevna
Radiation-induced morphea (RIM) is a rare and underrecognized complication of radiation therapy that most commonly occurs in women after treatment for breast cancer. Although not fully understood, RIM is hypothesized to arise from an increase in cytokines that stimulate collagen production and extracellular matrix formation. Most documented cases of RIM occur 1 year after radiation therapy and are localized to areas that were treated for breast cancer. We report on a case of a female patient with stage IB endometrial adenocarcinoma who was treated with 24 Gray of adjuvant brachytherapy...
December 2017: International Journal of Women's Dermatology
https://www.readbyqxmd.com/read/29177141/a-case-of-circumscribed-scalp-morphea-with-perineural-lymphocytes-on-pathology
#8
David Saceda-Corralo, Aron G Nusbaum, Paolo Romanelli, Mariya Miteva
Scalp morphea presents as a scarring alopecia in en coup du sabre pattern. We report an unusual presentation of a round hairless patch of morphea on the occipital scalp present for 15 years. The scalp lesion aligned with 2 other hyperpigmented lesions of biopsy-proven morphea in the lower back. Pathology of horizontal sections from the scalp lesion showed follicular dropout, thickening of the collagen bundles, and preserved eccrine and follicular structures. Marked lymphocytic perineural infiltrate, a reported clue to the diagnosis of scalp morphea, contributed to the diagnosis...
October 2017: Skin Appendage Disorders
https://www.readbyqxmd.com/read/29173689/esophageal-abnormalities-in-juvenile-localized-scleroderma-is-it-associated-with-other-extracutaneous-manifestations
#9
Clarissa C M Valões, Glaucia V Novak, Juliana B Brunelli, Katia T Kozu, Ricardo K Toma, Clovis A Silva
OBJECTIVE: To assess esophageal involvement (EI) in juvenile localized scleroderma (JLS) population and the possible association between this gastrointestinal manifestation and demographic data, clinical features, laboratory exams, treatments and outcomes. METHODS: For a period of 30 years, 5881 patients with rheumatic diseases were followed in our Pediatric Rheumatology Division. EI was defined by the presence of symptoms (solid/liquid dysphagia, heartburn, esophageal regurgitation, nausea/vomiting and epigastralgia) and confirmed by at least one EI exam abnormality: barium contrast radiography, upper gastrointestinal endoscopy and 24-hour esophageal pH-monitoring...
November 2017: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/29171400/reactivity-to-anti-rna-polymerase-iii-antibody-and-nailfold-capillary-changes-in-patients-with-generalized-morphea-combined-with-multiple-autoimmune-disorders
#10
Fumi Miyagawa, Hideo Asada
No abstract text is available yet for this article.
November 24, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29166431/coexistence-of-morphea-and-granuloma-annulare-a-rare-case-report
#11
Şenay Ağırgöl, Özge Yöntem, Cem Leblebici, Tuğba Özkök Akbulut, Filiz Topaloğlu Demir, Zafer Türkoğlu
CONTEXT: Localized scleroderma (morphea) is characterized by fibrosis of skin and subcutaneous tissue. Granuloma annulare is a relatively common disease that is characterized by dermal papules and arciform plaques. CASE REPORT: Here, we present the case of a 42-year-old woman who developed granuloma annulare on the dorsum of her feet and abdominal region, and morphea on the anterior side of her lower limbs. We also discuss the etiological and pathogenetic processes that may cause the rare coexistence of these two diseases...
November 17, 2017: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/29165838/discordance-of-pediatric-morphea-treatment-by-pediatric-dermatologists
#12
Megha M Tollefson, Yvonne E Chiu, Heather A Brandling-Bennett, Elena Pope
BACKGROUND/OBJECTIVES: Studies describing treatment efficacy in pediatric morphea are lacking. Subspecialists have reached no consensus on how to optimally treat pediatric morphea. The objective of the current study was to describe the most common treatment practices of pediatric dermatologists worldwide who care for children with morphea. METHODS: A survey regarding topical treatment practices of pediatric morphea, with representative case-based scenarios, was distributed to pediatric dermatologists and results were tallied...
November 22, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/29164927/a-case-of-a-patient-with-residual-symptoms-of-schizophrenia-who-relapsed-following-treatment-with-the-topical-corticosteroid-clobetasol-a-review-of-its-risk-of-systemic-absorption-and-possibility-of-exacerbating-psychosis
#13
David R Spiegel, Umer Arsani, Stephanie Le
Almost fifty percent of patients with schizophrenia experience some type of dermatitis. The standard treatment for dermatitis is a topical corticosteroid. Despite their demonstrated effectiveness, topical corticosteroids are associated with various side effects that may limit their use. These include generalized adverse effects from systemic absorption, such as suppression of the hypothalamic-pituitary-adrenal axis. While dose-related, oral corticosteroid-induced psychiatric symptoms, such as psychosis, are well documented, the literature is devoid of cases of topical corticosteroids precipitating psychosis...
November 22, 2017: Clinical Schizophrenia & related Psychoses
https://www.readbyqxmd.com/read/29119592/orthopedic-complications-of-linear-morphea-implications-for-early-interdisciplinary-care
#14
REVIEW
Jennifer J Schoch, Bradley S Schoch, Jean David Werthel, Amy L McIntosh, Dawn M R Davis
Linear morphea of the limb primarily affects children, and extracutaneous manifestations are common. Orthopedic surgeons are often essential in the care of patients with linear morphea, yet there are few reports outlining specific orthopedic complications in this population. We sought to improve the understanding of orthopedic complications in linear morphea of the limb. Between 1999 and 2014, 51 children were evaluated for linear morphea of an extremity. Twenty-six (51%) had documented orthopedic manifestations...
November 9, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/29110020/granuloma-annulare-and-morphea-correlation-with-borrelia-burgdorferi-infections-and-chlamydia-related-bacteria
#15
Lauri Tolkki, Kati Hokynar, Seppo Meri, Jaana Panelius, Mirja Puolakkainen, Annamari Ranki
A retrospective study of 109 skin biopsies with granuloma annulare (GA) or morphea histology from patients with suspected tick bite was performed. Biopsies were tested for cutaneous Borrelia burgdorferi DNA using PCR. The same biopsies were analysed for tick-borne novel agents, Chlamydia-related bacteria (members of the Chlamydiales order), using a PCR-based method. Borrelia DNA was detected in 7/73 (9.6%) biopsies with GA and in 1/36 (2.8 %) biopsies with morphea, while Chlamydiales DNA was found in 53/73 (72...
November 7, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/29025691/morphea-and-extragenital-lichen-sclerosus-et-atrophicus-after-influenza-vaccination
#16
S Requena López, Y Hidalgo García, S Gómez Díez, B Vivanco Allende
No abstract text is available yet for this article.
October 9, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28993235/the-wood-s-lamp-as-a-tool-in-the-evaluation-of-morphea
#17
Paul Curtiss, Gaurav Singh, Kristen Lo Sicco, Andrew G Franks
No abstract text is available yet for this article.
October 6, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28966531/delayed-treatment-of-generalized-morphea-due-to-misdiagnosis-as-vitiligo-at-an-oriental-medical-clinic
#18
Howard Chu, Jae Won Lee, Young In Lee, Do Young Kim
No abstract text is available yet for this article.
October 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28954874/fibrous-arthropathy-associated-with-morphea-a-new-cause-of-diffuse-acquired-joint-contractures
#19
Etienne Merlin, Sylvain Breton, Sylvie Fraitag, Jean-Louis Stéphan, Carine Wouters, Christine Bodemer, Brigitte Bader-Meunier
Etiologies for childhood-onset diffuse joint contractures encompass a large group of inherited disorders and acquired diseases, in particular a subtype of juvenile idiopathic arthritis called "dry polyarthritis," dermatomyositis, and systemic sclerosis. We report on 2 boys, aged 5 and 8 years, who developed acquired symmetric painless joint contractures preceding the development of superficial plaques of morphea by 7 to 13 months. There was no other clinical involvement, biological inflammation, or autoantibodies...
October 2017: Pediatrics
https://www.readbyqxmd.com/read/28951708/morphea-in-middle-anatolia-turkey-a-5-year-single-center-experience
#20
Isil Bulur, Hilal Kaya Erdoğan, Tekden Karapınar, Zeynep Nurhan Saracoglu
INTRODUCTION: Morphea, also referred to as localized scleroderma, is a rare fibrosing skin disorder of undetermined cause. AIM: We report our single-center experience with morphea. MATERIAL AND METHODS: The study included 53 patients who were diagnosed with morphea by histopathology in our department between 2010 and 2015. Study data were collected retrospectively from the records of morphea patients. RESULTS: The study included 53 patients (38 women, 15 men), and median age at onset was 39...
August 2017: Postȩpy Dermatologii i Alergologii
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