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Morphea

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https://www.readbyqxmd.com/read/28898915/-current-therapies-in-superficial-malignant-tumors
#1
Simone Luisa Scholz, Anja Eckstein, Dirk Dekowski, Joachim Esser, Henrike Westekemper, Klaus P Steuhl
This article is a review of diagnostic and therapeutic possibilities in common epibulbar malignant tumors, such as basal cell carcinoma, conjunctival lymphoma, squamous cell carcinoma and conjunctival melanoma. Most importantly, for every tumor patient there is a detailed anamnesis, split lamp examination and photo documentation. Further regular controls after therapy are required due to the risk of recurrences.Basal cell carcinoma is the most common tumor of the periocular skin, divided into three subtypes (nodular, superficial and morphea)...
September 12, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28895373/nodular-morphea-in-a-patient-with-steinert-disease
#2
Elena Campione, Alessandra Ventura, Virginia Garofalo, Claudia Torti, Roberto Massa, Chiara Terracciano, Augusto Orlandi, Luca Bianchi
No abstract text is available yet for this article.
September 8, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28865864/clinicopathologic-and-immunophenotypic-features-of-eosinophilic-fasciitis-and-morphea-profunda-a-comparative-study-of-27-cases
#3
Oluwakemi Onajin, Carilyn N Wieland, Margot S Peters, Christine M Lohse, Julia S Lehman
BACKGROUND: Eosinophilic fasciitis (EF) and morphea profunda (MP) are inflammatory and sclerosing disorders of the subcutis that can exhibit clinical and pathologic presentations that overlap. OBJECTIVE: To identify clinicopathologic features that can be used to distinguish EF from MP. METHODS: We performed a retrospective review of 16 patients with EF and 11 patients with MP. Hematoxylin-eosin, CD123, CD34, and Verhoeff-Van Gieson stains were evaluated on skin biopsies that included the fascia...
August 30, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28839399/linear-morphea-alopecia-new-trichoscopy-findings
#4
Claudia Liliana Montoya, Natalia Calvache
No abstract text is available yet for this article.
April 2017: International Journal of Trichology
https://www.readbyqxmd.com/read/28760502/-extensive-connective-tissue-nevus-in-children
#5
O Lafargue, S Fraitag, O Boccara, F Comoz, J Rod, C Turgis Mezerette, A Dompmartin
BACKGROUND: Connective tissue nevus (CTN) is a rare condition of the extracellular matrix components that generally presents as papulae of normal skin colour. This condition may be syndromic or sporadic. PATIENTS AND METHODS: We report herein two isolated cases of extensive and infiltrative CTN in children at risk for subsequent joint stiffening. The pathology samples displayed respectively mixed hamartoma and a collagenoma. DISCUSSION: The onset of these lesions is often difficult to establish, since they are usually unnoticeable at first...
July 28, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/28736199/decreased-hepatitis-b-vaccine-response-in-pediatric-patients-with-atopic-dermatitis-psoriasis-and-morphea
#6
Deepa P Patel, James R Treat, Leslie Castelo-Socio
Multiple groups of patients have been recognized for having high rates of non-responders to the Hepatitis B vaccine including those with HIV, inflammatory bowel disease, and chronic kidney disease. These patients are at increased risk for infection due to both the nature of their underlying diseases and the immunosuppressive drugs they are commonly prescribed. Identification of groups with high non-response rates is essential in order to establish vaccination guidelines and prevent serious infections in already susceptible patients...
August 16, 2017: Vaccine
https://www.readbyqxmd.com/read/28734566/long-term-outcome-of-eosinophilic-fasciitis-a-cross-sectional-evaluation-of-35-patients
#7
Jorre S Mertens, Rogier M Thurlings, Wietske Kievit, Marieke M B Seyger, Timothy R D Radstake, Elke M G J de Jong
BACKGROUND: Eosinophilic fasciitis (EF) is a connective tissue disease with an unknown long-term course. OBJECTIVE: To evaluate presence and determinants of residual disease damage in patients with EF after long-term follow-up. METHODS: Patients with biopsy-proven EF were included for this cross-sectional study. Outcome measures included the Physician's Global Assessment of Disease Activity, Physician's Global Assessment of Damage (PhysGA-D), skin pliability scores, passive range of motion, and health-related quality of Life (HRQoL) questionnaires...
September 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28608042/-granulomatous-reaction-pattern-of-the-skin-interstitial-granulomatous-dermatitis-lymphoma-vasculitis
#8
REVIEW
C Rose, K Holl-Ulrich
A particular diagnostic situation in the classification of a granulomatous dermatitis results when no circumscribed granulomas but instead a diffuse interstitial histiocytic inflammatory infiltrate, a granulomatous vasculitis or a neoplastic lymphocytic infiltrate is found. Interstitial granulomatous dermatitis was originally described in patients with arthritis. Later, it was recognized that there are also associations with other usually immunological diseases. Differentiating between interstitial granulomatous dermatitis and the interstitial form of granuloma annulare, early morphea and variants of borreliosis or scleromyxedema as well as interstitial granulomatous drug reaction can be very difficult...
July 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/28604132/the-efficacy-of-methotrexate-in-the-treatment-of-en-coup-de-sabre-linear-morphea-subtype
#9
Ploysyne Rattanakaemakorn, Joseph Jorizzo
BACKGROUND: En coup de sabre is a rare subtype of linear morphea, located on the forehead or frontoparietal scalp. Systemic treatment of localized morphea with methotrexate has been reported in a few clinical reports. However, there are no case series using methotrexate treatment for En coup de sabre. OBJECTIVE: To evaluate the efficacy and tolerability of methotrexate in the treatment of en coup de sabre linear morphea subtype. METHOD: A retrospective chart review was performed for pediatric and the adult patients with en coup de sabre evaluated in the Dermatology Clinic at Wake Forest University School of Medicine treated with methotrexate...
June 12, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28543515/thrombocytopenia-associated-with-localized-scleroderma-report-of-four-pediatric-cases-and-review-of-the-literature
#10
Ankur Kumar Jindal, Anju Gupta, Sunil Dogra, Amit Rawat, Deepti Suri, Jasmina Ahluwalia, Surjit Singh
We report on four children with localized scleroderma (morphea) and thrombocytopenia. All four had the en coup de sabre subtype of morphea and had varying degrees of thrombocytopenia (8 × 10(9) /L to 120 × 10(9) /L). None of them had major bleeding manifestations, and thrombocytopenia resolved with treatment of morphea. (One patient was also given an injection of anti-D immunoglobulin.) We propose that thrombocytopenia associated with localized scleroderma is usually benign and requires no specific therapy...
May 23, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28543434/metastatic-squamous-cell-carcinoma-in-a-patient-with-disabling-pansclerotic-morphea-of-childhood
#11
Juan M Ruiz-Matta, Luis R Flores-Bozo, Judith Dominguez-Cherit
Disabling pansclerotic morphea of childhood (DPMC) is a rare disorder that confers a risk of developing ulcer-related squamous cell carcinoma (SCC). We describe a young man with long-standing DPMC and SCC with lung metastasis.
May 23, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28537856/superficial-morphea-case-report-look-alikes-pathogenesis-and-treatment
#12
Jameson Loyal, Ivy I Norris, Elizabeth B Lester, Joseph C Pierson
Superficial morphea, a rare variant of morphea, is characterized by hypopigmented to hyperpigmented skin lesions located predominantly in a symmetric fashion at intertriginous sites. These patches and plaques typically lack the significant induration, contractures, and atrophy seen in other subtypes of morphea. Histologic examination is key for accurate diagnosis considering the number of similar conditions which may clinically mimic superficial morphea. Herein, we present a case of a 25-year-old woman who re-presented for consultation in our clinic after gradual progression of her skin lesions...
May 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28507446/methotrexate-an-effective-monotherapy-for-refractory-generalized-morphea
#13
Eftychia Platsidaki, Vassiliki Tzanetakou, Anargyros Kouris, Panagiotis G Stavropoulos
INTRODUCTION: Morphea is an inflammatory skin disorder characterized by excessive collagen deposition. Although treatment algorithms for morphea subtypes have been suggested, no consistent recommendations are available. This study attempts to evaluate the clinical efficacy of methotrexate (MTX) as monotherapy in refractory generalized morphea. METHODS: It is a retrospective study, including 20 patients who had already been treated with various topical and systemic therapies with minimal clinical improvement...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28475513/nodular-sclerodermatous-chronic-cutaneous-graft-versus-host-disease-gvhd-a-new-clinicopathological-variant-of-cutaneous-sclerodermatous-gvhd-resembling-nodular-keloidal-scleroderma
#14
Lucía Prieto-Torres, Francesca Boggio, Alexandra Gruber-Wackernagel, Lorenzo Cerroni
Cutaneous chronic graft-versus-host disease (GvHD) has a broad spectrum of clinicopathological presentations, the most common ones being poikiloderma, lichen planus-like eruptions, lichen sclerosus-like lesions, morphea-like plaques, and deep sclerosis. New forms of chronic cutaneous GvHD with different clinicopathological characteristics have been described, most of them mimicking cutaneous manifestations of autoimmune diseases. We report the case of a 35-year-old man who underwent allogenic stem cell transplantation for a therapy-associated acute myeloid leukemia and developed an acute GvHD with involvement of skin and gastrointestinal tract...
April 25, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28450066/transcriptional-and-cytokine-profiles-identify-cxcl9-as-a-biomarker-of-disease-activity-in-morphea
#15
Jack C O'Brien, Yevgeniya Byekova Rainwater, Neeta Malviya, Nika Cyrus, Lorenz Auer-Hackenberg, Linda S Hynan, Gregory A Hosler, Heidi T Jacobe
IFN-related pathways have not been studied in morphea, and biomarkers are needed. We sought to characterize morphea serum cytokine imbalance and IFN-related gene expression in blood and skin to address this gap by performing a case-control study of 87 participants with morphea and 26 healthy control subjects. We used multiplexed immunoassays to determine serum cytokine concentrations, performed transcriptional profiling of whole blood and lesional morphea skin, and used double-staining immunohistochemistry to determine the cutaneous cellular source of CXCL9...
August 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28425227/primary-sj%C3%A3-gren-s-syndrome-in-patients-with-celiac-disease
#16
Funda Erbasan, Deniz Turgut Çoban, Uğur Karasu, Yeşim Çekin, Bayram Yeşil, Ayhan Hilmi Çekin, Dinç Süren, Mustafa Ender Terzioğlu
BACKGROUND/AIM: Many autoimmune diseases occur concomitantly with celiac disease (CD). We aimed to determine the frequency of Sjögren's syndrome (SS) in CD patients based on SS-specific serology verified by minor labial salivary biopsy. MATERIALS AND METHODS: Eight-two patients with CD were included in the study. After examination for objective evidence of sicca complex, all patients were tested for serological presence of rheumatoid factor (RF) and antinuclear antibodies (ANAs) and for ANA profile...
April 18, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28393380/th1-and-th17-polarized-immune-infiltrates-in-eosinophilic-fasciitis-a-potential-marker-for-histopathologic-distinction-from-morphea
#17
Andrea Primiani Moy, Elena Maryamchik, Olga V Nikolskaia, Rosalynn M Nazarian
BACKGROUND: Morphea (localized scleroderma) and eosinophilic fasciitis (EF) are rare fibrosing disorders which may present a diagnostic challenge. While histopathologic features are often distinct, in some cases there may be overlap. T-cells contribute to etiopathogenesis of both autoimmune conditions. We sought to determine whether T-cell immune polarization enables histopathologic distinction. MATERIALS & METHODS: We retrospectively examined clinicopathologically confirmed cases of morphea (n = 12) and EF (n = 8) using immunohistochemistry for CD3, CD8, and dual staining for CD4 with T-bet, GATA-3, STAT-3 or BNC-2 (transcription factors reported to be specific and mutually exclusive for Th1, Th2, Th17 and Th22 cells, respectively) to characterize the T-cell infiltrate...
June 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28352933/erythema-multiforme-following-pneumococcal-vaccination
#18
Alexandra Monastirli, Efstathia Pasmatzi, George Badavanis, Dionysios Tsambaos
Erythema multiforme (EM) is an acute and usually self-limited immune-mediated mucocutaneous disorder that is a hypersensitivity reaction to drugs, infections, and vaccines. Clinically, it is characterized by maculopapular, target-like lesions symmetrically distributed on the extremities (minor form) or additionally affecting one or more mucous membranes and causing epidermal detachment involving < 10% of the total body surface area (major form). We report a novel association between pneumococcal vaccination and the development of EM in a 2...
March 2017: Acta Dermatovenerologica Alpina, Panonica, et Adriatica
https://www.readbyqxmd.com/read/28329476/pregnancy-associated-morphea-a-case-report-and-literature-review
#19
Anh Khoa Pham, Bhaskar Srivastava, April Deng
Morphea, also known as localized scleroderma, is arare fibrosing disorder of the skin, the pathogenesisof which is incompletely understood. It is thought,however, to involve interplay of genetic dispositionand triggering environmental factors, such asinfections and autoimmunity. Pregnancy as a potentialtrigger has only been reported in four cases. Herein,we present a patient who developed morphea of thebreasts during pregnancy, which rapidly resolvedwith a normal delivery. Our patient was distinct fromsome of the reported patients because her conditionwas tightly correlated with her pregnancy, as judgingby rapid resolution after delivery...
January 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28303481/morphea-and-eosinophilic-fasciitis-an-update
#20
REVIEW
Jorre S Mertens, Marieke M B Seyger, Rogier M Thurlings, Timothy R D J Radstake, Elke M G J de Jong
Morphea, also known as localized scleroderma, encompasses a group of idiopathic sclerotic skin diseases. The spectrum ranges from relatively mild phenotypes, which generally cause few problems besides local discomfort and visible disfigurement, to subtypes with severe complications such as joint contractures and limb length discrepancies. Eosinophilic fasciitis (EF, Shulman syndrome) is often regarded as belonging to the severe end of the morphea spectrum. The exact driving mechanisms behind morphea and EF pathogenesis remain to be elucidated...
August 2017: American Journal of Clinical Dermatology
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