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https://www.readbyqxmd.com/read/28229620/successful-infliximab-therapy-in-a-patient-with-comorbid-spondyloarthritis-primary-biliary-cirrhosis-and-generalized-morphea
#1
Hatice Resorlu, Sevilay Kılıc, Selda Isık, Ferhat Gokmen
The patient in this report was diagnosed simultaneously with primary biliary cirrhosis (PBC), spondyloarthritis, and generalized morphea and was started on infliximab therapy. In addition to an improvement in clinical symptoms with this therapy, an improvement was also observed in laboratory parameters such as cholestatic enzymes, C-reactive protein, and erythrocyte sedimentation rate. Infliximab was well tolerated in this 56-year-old patient. However, further studies must be performed in order to clarify the therapeutic role of TNF-α blockers in, PBC and generalized morphea...
February 23, 2017: Acta Clinica Belgica
https://www.readbyqxmd.com/read/28220270/multiplex-assessment-of-serum-cytokine-and-chemokine-levels-in-idiopathic-morphea-and-vitamin-k1-induced-morphea
#2
Lori Ann Cox, Guy F Webster, Sonsoles Piera-Velazquez, Sergio A Jimenez
The levels of 63 cytokines, chemokines, and growth factors were measured in the serum of four patients with idiopathic morphea and of one patient with vitamin K1-induced morphea employing a multiplex assay to identify the role of inflammatory/immunologic events in their pathogenesis. Full-thickness skin biopsies of affected skin were analyzed by histopathology. Luminex assays for 63 cytokines, chemokines, and growth factors were performed in the sera from four patients with idiopathic morphea and in two different samples of serum obtained in two separate occasions from one patient with vitamin K1-induced morphea...
February 20, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28216732/a-case-of-morphea-following-radiotherapy-for-an-intracranial-tumor-an-example-of-isoradiotopic-response
#3
Stefano Caccavale, Tobia Caccavale, Maddalena La Montagna
No abstract text is available yet for this article.
January 2017: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/28210455/morphea-en-coup-de-sabre-an-unusual-oral-presentation
#4
Sven Niklander, Constanza Marín, René Martínez, Alfredo Esguep
Morphea, or localized scleroderma, is an inflammatory disease that leads to sclerosis of the skin and underlying tissues due to excessive collagen deposition. Oral involvement is unusual and it may produce white linear fibrotic areas with a scar-like appearance, atrophy of tongue papillae, gingival recession and alveolar bone resorption. We report a case of a 13-year-old girl who consulted for progressive recession on the attached gingiva of her upper left incisors. She also presented a hypopigmented line on the left side skin of her upper lip, which continued through the vermilion and the lip mucosa, including the gingiva of the affected teeth...
February 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28134725/sclerosing-dermatofibrosarcoma-protuberans-shows-significant-overlap-with-sclerotic-fibroma-in-both-routine-and-immunohistochemical-analysis-a-potential-diagnostic-pitfall
#5
Maram Yousef Odeh Abdaljaleel, Jeffrey P North
Dermatofibrosarcoma protuberans (DFSP) is an uncommon, low-to-intermediate grade sarcoma with several histologic variants, including pigmented (Bednar tumor), sclerosing, myxoid, atrophic, and DFSP with fibrosarcomatous changes. Two patterns of sclerosis in DFSP can be observed, a sclerotic fibroma-like pattern and a morphea/lichen sclerosus-like pattern. Partial biopsies of sclerosing DFSPs with the sclerotic fibroma pattern can be misdiagnosed as sclerotic fibroma or other benign sclerosing tumors (eg, perineurioma, dermatofibroma)...
February 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28130554/effects-of-uva1-phototherapy-on-expression-of-human-endogenous-retroviral-sequence-herv-k10-gag-in-morphea-a-preliminary-study
#6
Michał Jacek Kowalczyk, Ewa Teresiak-Mikołajczak, Aleksandra Dańczak-Pazdrowska, Ryszard Żaba, Zygmunt Adamski, Agnieszka Osmola-Mańkowska
BACKGROUND Morphea, also known as localized scleroderma, is a rare autoimmune connective tissue disease characterized by skin fibrosis. UVA1 phototherapy is an important asset in the reduction of clinical manifestations in morphea. There are studies claiming that UV light modulates the expression of some human endogenous retroviral sequences. The aim of this study was to determine if the expression of HERV-K10 gag element is lowered by UVA1 phototherapy in morphea, a disease in which such irradiation has a soothing effect...
January 28, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28129926/panniculitis-a-summary
#7
Mark R Wick
The diagnosis of panniculitis is felt to be a confusing topic by some pathologists. This summarical article presents inflammatory diseases of the subcutis in a systematic fashion, based on whether they are centered on fibrovascular septa or the adipose lobules, and whether morphologic vasculitis is present or not. Septocentric, non-vasculitis disorders include erythema nodosum, panniculitis that follows the use of "biological" therapeutic agents, lipodermatosclerosis, post-irradiation panniculitis, morphea profunda, and necrobiosis lipodica profunda...
December 27, 2016: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/28110825/morphea-in-a-patient-with-psoriasis-on-treatment-with-ustekinumab-comorbidity-or-adverse-effect
#8
O Corral Magaña, J Escalas Taberner, M M Escudero Góngora, A Giacaman Contreras
No abstract text is available yet for this article.
January 19, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28032675/retinoic-acid-for-treatment-of-systemic-sclerosis-and-morphea-a-literature-review
#9
REVIEW
Renee M Thomas, Scott Worswick, Maria Aleshin
Systemic sclerosis and morphea are connective tissue diseases characterized by tightening, thickening, and hardening of the skin, leading to significant morbidity. Unfortunately, current treatment options have limited efficacy for many patients. Cutaneous manifestations of these diseases arise from excess collagen deposition and fibrosis in the skin, through pathogenic mechanisms which have yet to be extensively detailed at the causal immune and cellular levels. Research elucidating the mechanism of action of retinoic acid on collagen production in the skin and case series highlighting the success of retinoic acid on the skin manifestations of systemic sclerosis and on morphea demonstrate its promise as a treatment...
December 29, 2016: Dermatologic Therapy
https://www.readbyqxmd.com/read/28007667/early-localised-morphea-presenting-as-painful-abdominal-erythema
#10
Xiu-Lian Xu, Xue-Si Zeng, Jian-Fang Sun
No abstract text is available yet for this article.
December 20, 2016: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/27990392/primary-cutaneous-anaplastic-large-cell-lymphoma-masquerading-as-large-pyogenic-granuloma
#11
Anupama Bains, Deepak Vedant, Vinay Shanker, G R Tegta
Primary cutaneous anaplastic large cell lymphoma (pcALCL) forms 9% of the cutaneous T-cell lymphomas. It usually presents as solitary reddish brown ulcerating nodule or indurated plaque. Sometimes, it mimics other dermatological diseases such as eczema, pyoderma gangrenosum, pyogenic granuloma, morphea, and squamous cell carcinoma. Our case presented with large pyogenic granuloma like lesion with regional lymphadenopathy. Since pcALCL is rare, one can misdiagnose such cases and therefore high index of suspicion is necessary...
November 2016: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/27968927/autoimmune-collagen-vascular-diseases-kids-are-not-just-little-people
#12
Sean Timpane, Heather Brandling-Bennett, Arni K Kristjansson
Morphea, dermatomyositis (DM), and discoid lupus erythematosus (DLE) are autoimmune collagen vascular diseases that can present at any age. In all three of these diseases, the tenants of diagnosis and treatment are largely the same in both children and adults, with a few notable differences. Children with morphea are more likely to present with the linear subtype and have a higher incidence of extracutaneous manifestations. Children often need early aggressive systemic treatment to try to prevent long-term sequelae of morphea...
November 2016: Clinics in Dermatology
https://www.readbyqxmd.com/read/27920682/scleroderma-with-nodular-scleroderma
#13
Chutika Srisuttiyakorn, Kobkul Aunhachoke
BACKGROUND: Nodular scleroderma is a rare variant of scleroderma which can occur in connection with systemic sclerosis or morphea. A biopsy from the lesion can demonstrate the scleroderma pattern, i.e., keloid pattern or mixed type. Treatment is challenging, and several treatments modalities have been reported with unsatisfactory results. MAIN OBSERVATIONS: We present a case of systemic sclerosis in a 50-year-old female who developed nodular scleroderma in the absence of deterioration of the scleroderma condition...
September 2016: Case Reports in Dermatology
https://www.readbyqxmd.com/read/27919321/-morpheas-a-unique-form-of-diversity
#14
EDITORIAL
A Petit
No abstract text is available yet for this article.
December 2016: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/27833976/histopathological-and-clinical-traps-in-lichen-sclerosus-a-case-report
#15
Daciana Elena Brănişteanu, Daniel Constantin Brănişteanu, Gabriela Stoleriu, Dan Ferariu, Cătălina Maria Voicu, Loredana Elena Stoica, Constantin Căruntu, Daniel Boda, Florina Mihaela Filip-Ciubotaru, Andreea Dimitriu, Cezar Doru Radu
Lichen sclerosus et atrophicus and limited systemic scleroderma (acrosclerosis) are inflammatory skin diseases that ultimately evolve into two distinct modes of atrophic scar formation, but which can easily be confused clinically. They are very rarely associated. The literature has reported cases in which lichen sclerosus was associated with various forms of scleroderma, but often with localized morphea. The characteristic histopathological picture of lichen sclerosus includes a thin epidermis, with orthohyperkeratosis and vascular degeneration in the basal layer, loss of elastic fibers, and band-like inflammatory infiltrate in the papillary dermis, while systemic sclerosis is characterized by excessive deposition of collagen in the dermis, accompanied by reduction in adnexal structures and their entrapment in collagen, and the presence of perivascular lymphocytic inflammatory infiltrate...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/27832422/radiation-induced-lichen-sclerosus-of-the-vulva-first-report-in-the-medical-literature
#16
Lisa R Edwards, Emily D Privette, James W Patterson, Georgi Tchernev, Anastasiya Atanasova Chokoeva, Uwe Wollina, Torello Lotti, Barbara B Wilson
A 67-year-old woman presented with a firm plaque in the perineal region, 16 months after diagnosis of a high-grade basaloid squamous cell carcinoma of the vagina and treatment by external beam radiation therapy and vaginal cuff brachytherapy. The differential diagnosis included radiation-induced morphea, radiation dermatitis, or, possibly, radiation-induced lichen sclerosus. Biopsy findings, including special staining, confirmed the diagnosis of radiation-induced lichen sclerosus. To our knowledge, this is the first report of radiation-induced lichen sclerosus of the vulvar region...
November 10, 2016: Wiener Medizinische Wochenschrift
https://www.readbyqxmd.com/read/27831941/linear-sclerodermoid-lupus-erythematosus-profundus-in-a-child
#17
Amira Elbendary, John Griffin, Suzanne Li, Brook Tlougan, Jacqueline M Junkins-Hopkins
Lupus erythematosus panniculitis, also known as lupus profundus, is a variant in the clinicopathological spectrum of lupus erythematosus (LE) affecting about 2%-3% of LE patients. A linear configuration of LE panniculitis has been reported rarely with rare reports describing the coexistence of different forms of cutaneous LE and localized morphea. In this study, the authors present a 9-year-old girl with linear arrangement of subcutaneous nodules on her left forearm. Microscopic findings from 2 biopsies included lymphocytes at the dermoepidermal junction with mild interface dermatitis, a dense lymphocytic infiltrate that was concentrated around adnexae and subcutaneous fat in concert with thickened collagen bundles and mild widening of fibrous septae surrounding fat lobules...
December 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27776552/scleroderma-and-dentistry-two-case-reports
#18
Shantanu Dixit, Chaithra Kalkur, Atul P Sattur, Michael M Bornstein, Fred Melton
BACKGROUND: Scleroderma is a chronic connective tissue disorder with unknown etiology. It is characterized by excessive deposition of extracellular matrix in the connective tissues causing vascular disturbances which can result in tissue hypoxia. These changes are manifested as atrophy of the skin and/or mucosa, subcutaneous tissue, muscles, and internal organs. Such changes can be classified into two types, namely, morphea (localized) and diffuse (systemic). Morphea can manifest itself as hemifacial atrophy (Parry-Romberg syndrome) although this remains debatable...
October 24, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27773434/early-and-late-stage-morphea-subtypes-with-deep-tissue-involvement-is-treatable-with-abatacept-orencia
#19
Fahd Adeeb, Shakeel Anjum, Philip Hodnett, Ahmad Kashif, Mary Brady, Siobhan Morrissey, Joseph Devlin, Alexander Duncan Fraser
OBJECTIVES: This case series explores the potential efficacy of Abatacept in patients presenting with morphea subtypes and deep tissue involvement. METHODS: Three patients with established morphea subtypes and deep tissue involvement and with no contraindication to Abatacept were included in this prospective open-label study. The index patient was exceptionally severely affected with a mean Modified Rodnan Skin Score (MRSS) of 38/51. At baseline, whole-body MRI and skin biopsy were performed which confirmed classical deposition of dense fibrous tissue in the appropriate layer of the skin...
September 4, 2016: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/27761227/the-chronic-encephalopathy-of-parry-romberg-syndrome-and-en-coupe-de-sabre-with-a-31-year-history-in-a-west-indian-woman-clinical-immunologic-and-neuroimaging-abnormalities
#20
Karan Seegobin, Kamille Abdool, Kanterpersad Ramcharan, Haramnauth Dyaanand, Fidel Rampersad
We describe a case of Parry Romberg syndrome/en coupe de sabre in a woman whose disease started as seizures at age 8 but was diagnosed at the age 39. During these 31 years she got married, completed a first degree at university, had two successful pregnancies and has been gainfully employed. The features of generalized tonic-clonic seizures, autoimmune abnormalities, ocular abnormalities, morphea en coup de sabre and brain imaging abnormalities were present. Areas of parietal lobe cerebral calcification were encountered on the computed tomographic scan and bilateral periventricular white matter changes on the magnetic resonance imaging with frontal, temporal and parietal lobe brain atrophy ipsilateral to the facial hemiatrophy...
September 30, 2016: Neurology International
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