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Morphea

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https://www.readbyqxmd.com/read/29782295/diagnostic-and-treatment-strategies-of-dermatologists-for-treating-morphea-in-hungary
#1
Gábor Bali, Bernadett Hidvégi
Localized scleroderma is an uncommon disease, only infrequently encountered by dermatologists in private practices or even in larger academic centers. Because of its rarity, current treatment guidelines are mostly based on low-level clinical evidence and expert opinions. The aim of this study was to evaluate treatment strategies to treat localized scleroderma. A questionnaire was developed and sent to dermatologists in Hungary. 101 returned questionnaires were eligible for evaluation. 87.12% of clinicians employed local steroids...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29760873/early-morphea-simulating-patch-stage-mycosis-fungoides-in-two-cases
#2
Hamid R Ghasemi Basir, Pedram Alirezaei, Aliasghar Rezanejad, Sajjad Daneshyar
Morphea is a skin disorder characterized by thickening of dermis and subcutaneous tissues and loss of adnexal structures. In the early inflammatory stage of morphea, diagnostic histological findings are absent and this may lead to confusion with other inflammatory dermatoses such as mycosis fungoides (MF). We report two cases of early stage morphea mimicking patchstage of MF. Histopathologic examination of biopsies obtained early in the disease course revealed lymphocytic epidermotropism arranged in small pautrier-like collections as well as linear arrangements in dermal- epidermal junction...
April 23, 2018: Dermatology Reports
https://www.readbyqxmd.com/read/29760872/giant-morphea-form-basal-cell-carcinoma-of-the-umbilicus-successful-debulking-with-vismodegib
#3
Mariana Orduz Robledo, Eve Lebas, Marie-Annick Reginster, Mahmoud Baghaie, Sabine Groves, Arjen F Nikkels
Basal cell carcinoma of the umbilicus is very rare. The nodular subtype is the main representative. Giant basal cell carcinomas represent around 1% of all basal cell carcinomas. The hedgehog pathway inhibitor vismodegib is indicated for advanced basal cell carcinoma and CD56-negative immunostaining seems indicative for successful treatment. A 54-year-old man presented a 10 cm × 14 cm large and 4.5 cm deep morphea-form basal cell carcinoma with faint immunohistochemical CD56 expression arising from the umbilicus...
2018: Rare Tumors
https://www.readbyqxmd.com/read/29729451/disease-course-and-long-term-outcome-of-juvenile-localized-scleroderma-experience-from-a-single-pediatric-rheumatology-centre-and-literature-review
#4
REVIEW
Giorgia Martini, Gloria Fadanelli, Anna Agazzi, Fabio Vittadello, Alessandra Meneghel, Francesco Zulian
Juvenile Localized Scleroderma (JLS) is a rare disorder that may cause severe aesthetic sequelae and functional disability. To date, data on natural history and long-term outcome are discordant and difficult to compare due to the heterogeneity of clinical subtypes, treatments and methods to evaluate activity and outcome in previous studies. A retrospective and cross-sectional study including 133 patients followed between January 1991 and December 2016 was conducted at our Pediatric Rheumatology Centre. Disease course was drawn by retrospective analysis of patients' clinical features, treatment, disease course and outcome at the last evaluation...
May 2, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29728839/development-of-minimum-standards-of-care-for-juvenile-localized-scleroderma
#5
REVIEW
Tamás Constantin, Ivan Foeldvari, Clare E Pain, Annamária Pálinkás, Peter Höger, Monika Moll, Dana Nemkova, Lisa Weibel, Melinda Laczkovszki, Philip Clements, Kathryn S Torok
Juvenile localized scleroderma (jLS), also known as morphea, is an orphan disease. Pediatric guidelines regarding diagnosis, assessment, and management are lacking.Our objective was to develop minimum standards of care for diagnosis, assessment, and management of jLS. A systematic review was undertaken to establish the pediatric evidence for assessment and monitoring of jLS. An expert panel, including members of the Pediatric Rheumatology European Society (PRES) Scleroderma Working Group, were invited to a consensus meeting where recommendations were developed based on evidence graded by the systematic review and, where evidence was lacking, consensus opinion...
May 4, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29714655/localized-morphea-after-breast-implant-for-breast-cancer-a-case-report
#6
A Moretti, F Bianchi, I V Abbate, G Gherardi, M Bonavita, E Passoni, G Nazzaro, A Bramati, M C Dazzani, S Piva, E Paternò, N Frungillo, G Farina, N La Verde
PURPOSE: Early breast cancer follow-up guidelines for patients who underwent surgery suggest a regular and accurate clinical examination of the breast area, for an early identification of cutaneous or subcutaneous breast cancer relapse. Nonetheless, breast skin lesions arising in patients treated with mastectomy for breast cancer can be caused by several diseases. A series of diagnostic hypotheses should be considered, not only focusing on cutaneous metastasis, but also on dermatologic and systemic diseases...
March 1, 2018: Tumori
https://www.readbyqxmd.com/read/29697382/basal-cell-carcinoma-of-the-foot-two-case-reports-and-literature-review
#7
U Wollina, J Schönlebe, D Langner
Basal cell carcinoma (BCC) is considered the most common skin cancer in men. BCC of the foot, however, is very rare, and may occur on dorsal surface of the foot, foot sole or nail apparatus. Diagnosis is often delayed due to the location at an unusual site. We report on two patients: a 61-year-old female with an ulcerated BCC of the sole and dorsum of the foot on a leg with Klippel-Trénaunay syndrome and a 61-year-old male with an ulcerated BCC of the foot sole. Histologic tumor types were either metatypic or mixed solid and morphea-like with partial glandular infiltration...
March 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29625815/cutaneous-lupus-erythematosus-morphea-profunda-and-psoriasis-a-case-report
#8
Mónica García-Arpa, Miguel A Flores-Terry, Claudia Ramos-Rodríguez, Monserrat Franco-Muñoz, Lucía González-Ruiz, Marco Aurelio Ramírez-Huaranga
Psoriasis is a common inflammatory dermatosis that may be associated with a number of diseases. Recent studies provide evidence that there is a greater frequency of autoimmune diseases, but association with autoimmune connective tissue diseases is uncommon. The coexistence of psoriasis and lupus erythematosus is rare. Besides, the occurrence of morphea has rarely been reported in patients with lupus or psoriasis. We report a woman with cutaneous lupus and morphea profunda associated with psoriasis, with an excellent response to methotrexate, and review the literature...
April 3, 2018: Reumatología Clinica
https://www.readbyqxmd.com/read/29593811/expression-of-selected-genes-of-dendritic-and-treg-cells-in-blood-and-skin-of-morphea-patients-treated-with-uva1-phototherapy
#9
Agnieszka J Osmola-Mańkowska, Ewa Teresiak-Mikołajczak, Michał J Kowalczyk, Ryszard W Żaba, Zygmunt Adamski, Aleksandra Dańczak-Pazdrowska
Introduction: Morphea is a chronic autoimmune disease characterized by fibrosis of the skin. Dendritic cells (DC) and regulatory T cells (Tregs) play a significant role in development of autoimmune and tolerance mechanisms. The aim of the study was to establish the expression of selected genes of plasmacytoid and myeloid DC, Treg cells, and the microenvironment of cytokines (interleukin-17A (IL-17A), transforming growth factor β (TGF-β)) in blood and skin of morphea patients. In addition, the effect of UVA1 phototherapy on expression of the aforementioned genes was evaluated...
March 2018: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29535035/inflammatory-arthritis-in-pediatric-patients-with-morphea
#10
Sakeen W Kashem, Colleen K Correll, Richard K Vehe, Patricia M Hobday, Bryce A Binstadt, Sheilagh M Maguiness
BACKGROUND: Morphea or localized scleroderma is an inflammatory disorder resulting in fibrosis of the skin and subcutaneous tissues. Joint contractures, arthralgias, and functional compromise are recognized associations of pediatric morphea. The co-existence of inflammatory arthritis and morphea is not well-described in the literature. OBJECTIVE: To investigate the relationship between pediatric morphea and inflammatory arthritis with regards to cutaneous, musculoskeletal, and laboratory findings and treatment regimens...
March 10, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29507565/high-frequency-ultrasonography-hfus-as-a-useful-tool-in-differentiating-between-plaque-morphea-and-extragenital-lichen-sclerosus-lesions
#11
Rafał Białynicki-Birula, Radomir Reszke, Jacek C Szepietowski
Introduction: Morphea and lichen sclerosus (LS) are chronic inflammatory diseases that may pose a diagnostic challenge for a physician. High-frequency ultrasonography (HFUS) is a versatile diagnostic method utilized in dermatologic practice, allowing monitoring the course of the disease, treatment response and differentiation between certain skin disorders. Aim: To prove the usefulness of HFUS in differentiating between plaque morphea and extragenital LS lesions...
October 2017: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/29457011/trichoscopic-features-of-linear-morphea-on-the-scalp
#12
David Saceda-Corralo, Antonella Tosti
Linear scleroderma en coup de sabre (LSCS) is the most common form of morphea on the scalp and its trichoscopic features have not been described yet. We report 2 adult women with LSCS with distinct dermoscopic findings. They both had an atrophic well-defined linear patch of alopecia on the frontotemporal scalp. Dermoscopy showed loss of follicular openings on a whitish skin surface; scattered black dots, broken hairs, and pili torti; and short thick linear and branching tortuous vessels on the periphery of the lesion...
January 2018: Skin Appendage Disorders
https://www.readbyqxmd.com/read/29451694/children-with-facial-morphea-managing-everyday-life-a-qualitative-study
#13
E Stasiulis, B Gladstone, K Boydell, C O'Brien, E Pope, R Laxer
BACKGROUND: This study explores the everyday experiences of children with facial morphea by examining the psychosocial impact of living with facial morphea and how children and their families manage its impact. METHODS: We used a qualitative, social constructionist approach involving focus groups, in-depth interviews and drawing activities with 10 children with facial morphea 8-17 years of age and 13 parents. Interpretive thematic analysis was utilized to examine the data...
February 16, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29449213/inflammatory-morphea-presenting-as-a-hemifacial-acquired-port-wine-stain
#14
Andrea Bassi, Paola Piccini, Cesare Filippeschi, Teresa Oranges, Teresa Giani, Iria Neri, Rolando Cimaz, Maurizio de Martino
No abstract text is available yet for this article.
February 15, 2018: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29380800/an-overlap-case-of-parry-romberg-syndrome-and-en-coup-de-sabre-with-striking-ocular-involvement-and-anti-double-stranded-dna-positivity
#15
Hatice Ataş, Müzeyyen Gönül, Aysun Gökçe, Mutlu Acar, Canan Gürdal
Parry-Romberg syndrome (PRS) may overlap localized scleroderma (morphea) lesions with linear depression (en coup de sabre [ECDS]). Overlap case with PRS and ECDS was presented. Enophthalmos, uveitis, ocular torticollis, keratic linear precipitates, and anti-double-stranded DNA positivity were identified. Subendothelial keratic precipitates detected by an in vivo laser scanning confocal microscopy were the first profiled in the literature. Patients must be evaluated and followed up carefully by their clinics to prevent misdiagnosis and unnecessary procedures such as surgery of ocular torticollis as muscular torticollis...
February 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29368844/scleroderma-with-an-update-about-clinico-pathological-correlation
#16
Franco Rongioletti, Caterina Ferreli, Laura Atzori, Ugo Bottoni, Giuseppe Soda
Scleroderma is divided into a systemic form called systemic sclerosis and a localized form also called morphea. According to 2013 ACR/EULAR Classification Criteria for Systemic Sclerosis, developed by the American College of Rheumatology (ACR) and the European League Against Rheumatism (EULAR), skin thickening of the fingers extending proximal to the metacarpophalangeal joints is sufficient for a patient to be classified as having scleroderma. Histological examination is not included in the diagnostic criteria and is not routinely performed...
January 24, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29334870/linear-morphea-masquerading-as-superficial-thrombophlebitis
#17
Michael Jolly, Seth Bendo, Raghu Kolluri
No abstract text is available yet for this article.
January 1, 2018: Vascular Medicine
https://www.readbyqxmd.com/read/29332706/skin-mapping-for-the-classification-of-generalized-morphea
#18
Noelle Teske, Joseph Welser, Heidi Jacobe
BACKGROUND: Generalized morphea lacks cohesive clinical features, limiting its clinical and investigative utility. OBJECTIVE: We sought to use computerized lesion mapping to objectively subtype morphea. METHODS: We conducted a 2-part cross-sectional study. In part 1, we created a discovery cohort of patients with generalized morphea of whom lesion maps were created to characterize subsets. Clinical and demographic features were compared between proposed subsets to determine if they identified clinically relevant differences...
February 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29315793/mood-changes-with-methotrexate-therapy-for-dermatologic-disease
#19
Trisha Bhat, Carrie C Coughlin
Neurotoxicity and cognitive effects of low-dose methotrexate for rheumatologic disease have often been described, but the neuropsychiatric effects of low-dose methotrexate for cutaneous disease have been underreported in the dermatology literature. We describe two children who experienced mood changes with methotrexate treatment for lichen sclerosus with morphea overlap and psoriasis, with rapid resolution of these symptoms after methotrexate cessation. We also detail possible mechanisms underlying psychiatric changes with methotrexate therapy...
March 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29258795/esophageal-symptoms-and-their-lack-of-association-with-high-resolution-manometry-in-systemic-sclerosis-patients
#20
Ana Cecilia Arana-Guajardo, Gustavo Barrera-Torres, Miguel Ángel Villarreal-Alarcón, David Vega-Morales, Jorge Antonio Esquivel-Valerio
BACKGROUND: The esophageal involvement in systemic sclerosis (SSc) causes impact in the morbidity and mortality. High resolution manometry assesses esophageal involvement. Our aim was to categorize esophageal motor disorder in patients with SSc by HRM. METHODS: We carried out an observational, descriptive and cross-sectional study. All patients underwent HRM as well as semi-structured interviews to assess frequency and severity of upper GI symptoms. Patients also completed the gastroesophageal reflux questionnaire (Carlsson-Dent)...
December 16, 2017: Reumatología Clinica
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