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https://www.readbyqxmd.com/read/28109314/sickle-cell-disease-and-pregnancy-outcomes-a-study-of-the-community-based-hospital-in-a-tribal-block-of-gujarat-india
#1
Gayatri Desai, Ankit Anand, Pankaj Shah, Shobha Shah, Kapilkumar Dave, Hardik Bhatt, Shrey Desai, Dhiren Modi
BACKGROUND: Sickle cell disease (SCD) is a hereditary blood disorder prevalent in tribal regions of India. SCD can increase complications during pregnancy and in turn negatively influence pregnancy outcomes. This study reports the analysis of tribal maternal admissions in the community-based hospital of SEWA Rural (Kasturba Maternity Hospital) in Jhagadia block, Gujarat. The objective of the study is to compare the pregnancy outcomes among SCD, sickle cell trait and non-SCD admissions...
January 21, 2017: Journal of Health, Population, and Nutrition
https://www.readbyqxmd.com/read/28108646/postnatal-resveratrol-supplementation-improves-cardiovascular-function-in-male-and-female-intrauterine-growth-restricted-offspring
#2
Amin Shah, Anita Quon, Jude S Morton, Sandra T Davidge
Intrauterine growth restriction (IUGR) may predispose offspring to an increased susceptibility of developing cardiovascular disease (CVD) in adult life. The window of opportunity to treat later life CVD programmed in fetal life is critical. The aim of this study was to identify the effect of resveratrol treatment of IUGR offspring at a time of known CV dysfunction. Sprague-Dawley male and female rat offspring who experienced normoxia (21% O2; control) or hypoxia (11% O2; IUGR) in utero were fed a high-fat (HF) diet (3-21 weeks of age) or a HF diet (3-21 weeks of age) supplemented with resveratrol from 13 to 21 weeks of age...
January 2017: Physiological Reports
https://www.readbyqxmd.com/read/28104460/fetal-growth-retardation-and-brain-sparing-by-malnutrition-are-associated-to-changes-in-neurotransmitters-profile
#3
C García-Contreras, D Valent, M Vázquez-Gómez, L Arroyo, B Isabel, S Astiz, A Bassols, A Gónzalez-Bulnes
The present study assesses possible changes in the levels of different neurotransmitters (catecholamines and indoleamines) in fetuses affected by nutrient shortage. Hence, we determined the concentration of catecholamines and indoleamines at the hypothalamus of 56 swine fetuses obtained at both 70 and 90days of pregnancy (n=33 and 23 fetuses, respectively). The degree of fetal development and the fetal sex affected the neurotransmitters profile at both stages. At Day 70, there were found higher mean concentrations of l-DOPA in both female and male fetuses with severe IUGR; male fetuses with severe IUGR also showed higher concentrations of TRP than normal male littermates...
January 16, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/28102332/dynamic-modeling-of-uteroplacental-blood-flow-in-iugr-indicates-vortices-and-elevated-pressure-in-the-intervillous-space-a-pilot-study
#4
Christian J Roth, Eva Haeussner, Tanja Ruebelmann, Franz V Koch, Christoph Schmitz, Hans-Georg Frank, Wolfgang A Wall
Ischemic placental disease is a concept that links intrauterine growth retardation (IUGR) and preeclampsia (PE) back to insufficient remodeling of uterine spiral arteries. The rheological consequences of insufficient remodeling of uterine spiral arteries were hypothesized to mediate the considerably later manifestation of obstetric disease. However, the micro-rheology in the intervillous space (IVS) cannot be examined clinically and rheological animal models of the human IVS do not exist. Thus, an in silico approach was implemented to provide in vivo inaccessible data...
January 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28087247/activity-of-von-willebrand-factor-and-levels-of-vwf-cleaving-protease-adamts13-in-preterm-and-full-term-neonates
#5
T Strauss, N Elisha, B Ravid, N Rosenberg, A Lubetsky, S Levy-Mendelovich, I Morag, U Nowak Göttl, G Kenet
Von Willebrand Factor (VWF) has a central role in primary hemostasis. Its biological activity is related to the size of VWF multimers, spontaneously binding to platelets and inducing circulating microthrombi formation. This process is down-regulated by the VWF cleaving protease ADAMTS13 (A Disintegrin and Metalloprotease with ThromboSpondin motif). To date, information regarding the levels of ADAMTS13 in neonates and preterm infants is scarce. Our aim was to study ADAMTS13, VWF antigen (Ag) and Ristocetin cofactor (RiCof) activity in neonates and evaluate potential correlations with perinatal complications...
December 29, 2016: Blood Cells, Molecules & Diseases
https://www.readbyqxmd.com/read/28076856/mri-differences-associated-with-intrauterine-growth-restriction-in-preterm-infants
#6
Christie J Bruno, Shreyans Bengani, William A Gomes, Mariana Brewer, Melissa Vega, Xianhong Xie, Mimi Kim, Mamta Fuloria
BACKGROUND: Preterm infants are at risk for neurodevelopmental impairment. Intrauterine growth restriction (IUGR) further increases this risk. Brain imaging studies are often utilized at or near term-equivalent age to determine later prognosis. OBJECTIVE: To evaluate the association between intrauterine growth and regional brain volume on MRI scans performed in preterm infants at or near term-equivalent age. METHODS: This is a retrospective case-control study of 24 infants born at gestational age ≤30 weeks and cared for in a large, inner-city, academic neonatal intensive-care unit from 2012 to 2013...
January 11, 2017: Neonatology
https://www.readbyqxmd.com/read/28068596/evaluation-of-the-effectiveness-of-low-dose-aspirin-and-omega-3-in-treatment-of-asymmetrically-intrauterine-growth-restriction-a-randomized-clinical-trial
#7
Mohammed K Ali, Maggy E Amin, Ahmed F Amin, Diaa Eldeen M Abd El Aal
OBJECTIVE: To test the effect of aspirin and omega 3 on fetal weight as well as feto-maternal blood flow in asymmetrical intrauterine growth restriction (IUGR). STUDY DESIGN: This study is a clinically registered (NCT02696577), open, parallel, randomized controlled trial, conducted at Assiut Woman's Health Hospital, Egypt including 80 pregnant women (28-30 weeks) with IUGR. They were randomized either to group I: aspirin or group II: aspirin plus omega 3. The primary outcome was the fetal weight after 6 weeks of treatment...
January 3, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28062958/a-study-of-oxidative-stress-in-neonates-delivered-through-meconium-stained-amniotic-fluid
#8
Tapas Bandyopadhyay, B D Bhatia, H D Khanna
: To estimate the levels of malondialdehyde (MDA) and 8-hydroxy-2-deoxyguanosine (8-OH-dG) in cord blood plasma of newborns born through meconium-stained amniotic fluid (MSAF) and also to find out the correlation between their levels with birth weight and gestation, we measured the cord blood plasma levels of MDA and 8-OH-dG in 59 newborns born through MSAF and 50 newborns born through clear liquor. The levels of cord blood plasma MDA and 8-OH-dG were significantly higher in full-term and late-preterm newborns born through MSAF...
January 6, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28057383/reference-values-for-nucleated-red-blood-cells-and-serum-lactate-in-very-and-extremely-low-birth-weight-infants-in-the-first-week-of-life
#9
Martin Poryo, Antonia Wissing, Aylin Aygün, Jürgen Geisel, Stefan Wagenpfeil, Michael Zemlin, Sascha Meyer
STUDY PURPOSE: To provide reference values for nucleated red blood cells and serum lactate concentrations in very and extremely low birth weight (VLBW/ELBW) infants in the first week of life. PATIENTS AND METHODS: Retrospective data analysis of serial, daily measurements of NRBC counts and serum lactate during the first 6days of life in VLBW and ELBW infants. RESULTS: In total, 250 infants<1500g were included in this study. Intrauterine growth retardation (IUGR) was seen in 87 (34...
January 2, 2017: Early Human Development
https://www.readbyqxmd.com/read/28053000/myoblast-replication-is-reduced-in-the-iugr-fetus-despite-maintained-proliferative-capacity-in-vitro
#10
Susan M Soto, Amy C Blake, Stephanie R Wesolowski, Paul J Rozance, Kristen B Barthel, Bifeng Gao, Byron Hetrick, Carrie McCurdy, Natalia G Garza, William Hay, Leslie A Leinwand, Jacob E Friedman, Laura D Brown
Adults who were affected by intrauterine growth restriction (IUGR) suffer from reductions in muscle mass and insulin resistance, suggesting muscle growth may be restricted by molecular events that occur during fetal development. To explore the basis of restricted fetal muscle growth, we used a sheep model of progressive placental insufficiency-induced IUGR to assess myoblast proliferation within intact skeletal muscle in vivo and isolated myoblasts stimulated with insulin in vitro. Gastrocnemius and soleus muscle weights were reduced by 25% in IUGR fetuses compared to controls (CON)...
January 4, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28046002/competition-for-materno-fetal-resource-partitioning-in-a-rabbit-model-of-undernourished-pregnancy
#11
Jorge Lopez-Tello, Maria Arias-Alvarez, Maria Angeles Jimenez-Martinez, Rosa Maria Garcia-Garcia, Maria Rodriguez, Pedro Luis Lorenzo Gonzalez, Ruben Bermejo-Poza, Antonio Gonzalez-Bulnes, Pilar Garcia Rebollar
The major goal of animal production is to obtain abundant and healthy meat for consumers. Maternal food restriction (MFR) is often applied in farms to reduce production costs. However, the suitability of MFR in livestock animals is questionable, as this management may compromise maternal fitness due to a severe negative energetic balance and can induce Intrauterine Growth Restriction (IUGR) and prenatal programming in the offspring. Here, we sought to determine, using pregnant rabbits, the consequences of MFR on maternal endocrine and metabolic status and conceptus development...
2017: PloS One
https://www.readbyqxmd.com/read/28008304/structural-brain-network-reorganization-and-social-cognition-related-to-adverse-perinatal-condition-from-infancy-to-early-adolescence
#12
Emma Muñoz-Moreno, Elda Fischi-Gomez, Dafnis Batalle, Cristina Borradori-Tolsa, Elisenda Eixarch, Jean-Philippe Thiran, Eduard Gratacós, Petra S Hüppi
Adverse conditions during fetal life have been associated to both structural and functional changes in neurodevelopment from the neonatal period to adolescence. In this study, connectomics was used to assess the evolution of brain networks from infancy to early adolescence. Brain network reorganization over time in subjects who had suffered adverse perinatal conditions is characterized and related to neurodevelopment and cognition. Three cohorts of prematurely born infants and children (between 28 and 35 weeks of gestational age), including individuals with a birth weight appropriated for gestational age and with intrauterine growth restriction (IUGR), were evaluated at 1, 6, and 10 years of age, respectively...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28004624/intrauterine-growth-restriction-increases-circulating-mitochondrial-dna-and-toll-like-receptor-9-expression-in-adult-offspring-could-aerobic-training-counteract-these-adaptations
#13
V Oliveira, S D Silva Junior, M H C de Carvalho, E H Akamine, L C Michelini, M C Franco
It has been demonstrated that intrauterine growth restriction (IUGR) can program increase cardiometabolic risk. There are also evidences of the correlation between IUGR with low-grade inflammation and, thus can contribute to development of several cardiometabolic comorbidities. Therefore, we investigated the influence of IUGR on circulating mitochondrial DNA (mtDNA)/Toll-like receptor 9 (TLR9) and TNF-α expression in adult offspring. Considering that the aerobic training has anti-inflammatory actions, we also investigated whether aerobic training would improve these inflammatory factors...
December 22, 2016: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/28004456/maternal-endothelial-function-and-vascular-stiffness-after-hellp-syndrome-a-case-control-study
#14
Rossana Orabona, Edoardo Sciatti, Enrico Vizzardi, Ivano Bonadei, Federico Prefumo, Adriana Valcamonico, Marco Metra, Tiziana Frusca
OBJECTIVES: To assess endothelial function and arterial stiffness in women with a previous pregnancy complicated by haemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome, and compare them with women with a previous preeclampsia (PE) without HELLP and controls with uncomplicated pregnancies. METHODS: Women who have had a singleton pregnancy complicated by PE with (n = 49) or without (n = 60) HELLP syndrome and controls (n = 60) underwent peripheral arterial tonometry (EndoPAT method) and pulse wave velocity (PWV) assessment at 6 months-4 years after delivery...
December 22, 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27999824/perinatal-outcome-in-assisted-reproductive-pregnancies-comparative-analysis-of-reduced-versus-unreduced-gestation
#15
Shilpa Bhandari, Pallavi Agrawal, Ishita Ganguly, Aparna Singh, Nitika Gupta
Objectives. This study aims to evaluate perinatal outcomes such as gestational age at delivery and live birth rate in singleton and twin gestation with or without fetal reduction. Method. A retrospective analysis was done on patients which were divided into reduced and unreduced groups on the basis of order of reduction of one or more fetuses between 6 and 13 weeks of gestation. Patients records were studied to note gestational age at delivery/abortion, birth weight, and neonatal outcome. Result. The cohort included a total of 292 patients: 102 singletons and 190 twins...
2016: International Journal of Reproductive Medicine
https://www.readbyqxmd.com/read/27988927/cardiac-remodelling-in-a-baboon-model-of-intrauterine-growth-restriction-mimics-accelerated-ageing
#16
Anderson H Kuo, Cun Li, Jinqi Li, Hillary F Huber, Peter W Nathanielsz, Geoffrey D Clarke
KEY POINTS: Rodent models of intrauterine growth restriction (IUGR) successfully identify mechanisms that can lead to short-term and long-term detrimental cardiomyopathies but differences between rodent and human cardiac physiology and placental-fetal development indicate a need for models in precocial species for translation to human development. We developed a baboon model for IUGR studies using a moderate 30% global calorie restriction of pregnant mothers and used cardiac magnetic resonance imaging to evaluate offspring heart function in early adulthood...
November 6, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27958670/resveratrol-attenuates-mitochondrial-dysfunction-in-the-liver-of-intrauterine-growth-retarded-suckling-piglets-by-improving-mitochondrial-biogenesis-and-redox-status
#17
Hao Zhang, Yue Li, Weipeng Su, Zhixiong Ying, Le Zhou, Lili Zhang, Tian Wang
SCOPE: Emerging evidence has identified mitochondrial biogenesis and oxidative phosphorylation as potential targets for the prevention and treatment of metabolic syndrome. This study investigated the effect of resveratrol (RSV) on hepatic mitochondrial function in intrauterine growth-retarded (IUGR) suckling piglets. METHODS AND RESULTS: Seven normal birth weight (NBW) and fourteen IUGR neonatal male piglets were selected. Piglets were fed control diets supplemented with 0 (NBW-CON), 0 (IUGR-CON), and 1...
December 13, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27956250/maternal-di-2-ethylhexyl-phthalate-exposure-during-pregnancy-causes-fetal-growth-restriction-in-a-stage-specific-but-gender-independent-manner
#18
Ru Shen, Ling-Li Zhao, Zhen Yu, Cheng Zhang, Yuan-Hua Chen, Hua Wang, Zhi-Hui Zhang, De-Xiang Xu
Di (2-ethylhexyl) phthalate (DEHP) is male developmental toxicant that impairs testis development with reduced anogenital distance. The present study aimed to investigate whether maternal DEHP exposure during pregnancy causes intrauterine growth restriction (IUGR) in a gender-specific manner and to identify the critical window of DEHP-induced fetal IUGR. Pregnant mice were administered with DEHP (0, 50 or 200mg/kg) by gavage. Fetal IUGR was observed not only in males but also in females when litters were exposed to DEHP on gestational day (GD)0-GD17...
December 9, 2016: Reproductive Toxicology
https://www.readbyqxmd.com/read/27941748/congenital-complete-heart-block-presenting-in-pregnancy-a-case-report
#19
S Rouf, A W Chowdhury
Congenital complete heart block presenting for the first time in pregnancy is a rare occurrence posing a therapeutic challenge. We present a case of unpaced preexisting congenital complete heart block in pregnancy diagnosed for the first time during routine prenatal care at her early weeks of gestation. Our patient was asymptomatic and haemodynamically stable and was managed conservatively with a multidisciplinary term approach. Intrauterine growth retardation (IUGR) was present and she was delivered by ceasarean section at term for foetal distress with IUGR...
October 2016: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/27941724/status-of-low-birth-weight-babies-in-mymensingh-medical-college-hospital
#20
M A Ali, T Latif, M N Islam, M A Hossain, H J Fakir, S A Haque, R H Khan, B Chowdhury
Low birth weight (LBW) is the major neonatal health problem in Bangladesh like other developing countries with limited resource. But only a few studies had done about status of LBW at hospital setting in this country. The objective of the study that to evaluate the status and immediate outcome of the LBW This cross sectional retrospective study was done in neonatal ward of Mymensingh medical college hospital. In this 1000 bedded tertiary care level teaching hospital only 40 cots and 10 open incubators are sanctioned but daily average admission in neonatal ward more than 30...
October 2016: Mymensingh Medical Journal: MMJ
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