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https://www.readbyqxmd.com/read/29149538/psychologic-intimate-partner-violence-and-the-risk-of-intrauterine-growth-restriction-in-rio-de-janeiro
#1
Gustavo Lobato, Michael E Reichenheim, Claudia L Moraes, Fernando M Peixoto-Filho, Lívia S Migowski
OBJECTIVE: To evaluate whether psychologic intimate partner violence (IPV) during pregnancy is a risk factor for intrauterine growth restriction (IUGR). METHODS: The cross-sectional study enrolled 810 randomly selected mothers of infants younger than 5 months attending basic health services in Rio de Janeiro, Brazil, from January to July 2007. Psychologic and physical IPV were evaluated by the Revised Conflict Tactics Scale; IUGR was defined as below the 10th percentile of the Alexander curve...
November 17, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29142763/array-characterization-of-prenatally-diagnosed-15q26-microdeletion-and-2q37-1-duplication-report-of-a-new-case-with-multicystic-kidneys-and-review-of-the-literature
#2
Molka Kammoun, Wafa Slimani, Hanene Hannachi, Mohamed Bibi, Ali Saad, Soumaya Mougou-Zerelli
We report on a molecular cytogenetic characterization of 15q26 deletion and 2q37.1 duplication in a fetus presenting with intrauterine growth restriction (IUGR), diaphragmatic hernia, multicystic kidneys, left kidney pyelectasis, and clubfeet. A terminal 15q26 deletion and a terminal 2q duplication of at least 10 and 9 Mb, respectively, derived from a maternal translocation, were found. The 15q26 deletion represents a contiguous gene deletion syndrome mainly characterized by IUGR, congenital diaphragmatic hernia, and less frequently kidney defects...
December 2017: Journal of Pediatric Genetics
https://www.readbyqxmd.com/read/29130966/itraq-based-proteomic-analysis-of-neonatal-kidney-from-offspring-of-protein-restricted-rats-reveals-abnormalities-in-intraflagellar-transport-proteins
#3
Xiaomei Liu, Jun Wang, Linlin Gao, Hao Liu, Caixia Liu
BACKGROUND: It is well recognized that adverse events in utero can impair fetal development and lead to the development of kidney injury and hypertension in adulthood. We previously reported a lower kidney index, glomeruli number, and decreased glomerular filtration rate in intrauterine growth restriction (IUGR) offspring induced by maternal protein malnutrition. To explore the molecular mechanisms linking impaired fetal growth to renal diseases, we investigated differentially expressed proteins (DEPs) in the IUGR neonatal kidneys by isobaric tags for relative and absolute quantitation (iTRAQ) analysis...
November 6, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29130759/preeclampsia-in-pregnancies-complicated-by-sle-nephritis-prophylactic-treatment-with-multidisciplinary-approach-are-important-keys-to-prevent-adverse-obstetrics-outcomes
#4
Federico Mecacci, Serena Simeone, Calogero Lino Cirami, Mauro Cozzolino, Caterina Serena, Marianna Pina Rambaldi, Pamela Gallo, Lorenzo Emmi, Daniele Cammelli, Giorgio Mello, Marco Matucci Cerinic
INTRODUCTION: Systemic lupus erythematosus (SLE) commonly affects women of childbearing age. Hypertension, antiphospholipid syndrome and lupus nephritis are risk factors for adverse maternal/fetal outcome. The aim of this retrospective cohort study is to compare pregnancy outcomes in patients with and without SLE nephritis, using a multidisciplinary approach and a broad prophylaxis protocol. MATERIALS AND METHODS: Data were collected from 86 pregnancies complicated by SLE...
November 12, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29107968/the-trophoblast-survival-capacity-in-preeclampsia
#5
Martina Hutabarat, Noroyono Wibowo, Berthold Huppertz
BACKGROUND: Preeclampsia has become the world's major maternal health problem putting a huge burden on mothers, newborns and also on the health systems. The pathogenesis of preeclampsia seems to include events in very early pregnancy affecting differentiation of placental villous trophoblast. The arising changes of the cell death spectrum from apoptosis via increased autophagy and aponecrosis to necrosis in turn induce systemic inflammation of the mother. METHODS: Placental tissue samples and maternal serum samples from 40 pregnant women were collected from normal pregnancy, IUGR, early-onset and late-onset preeclampsia...
2017: PloS One
https://www.readbyqxmd.com/read/29103476/evaluation-of-fetal-kidney-growth-using-ultrasound-a-systematic-review
#6
REVIEW
Sonja Brennan, David Watson, Donna Rudd, Michal Schneider, Yogavijayan Kandasamy
PURPOSE: To determine the role of ultrasound imaging in evaluating fetal kidney growth. METHODS: MEDLINE, CINAHL and EMBASE databases were electronically searched for studies between 1996 and January 2017 and limited to English language. Studies were included if they reported on an ultrasound technique to assess fetal kidney growth and they were not a case report or case series. There was independent selection of studies by two reviewers in consensus with one other reviewer...
November 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/29098705/intrauterine-growth-restriction-results-in-persistent-vascular-mismatch-in-adulthood
#7
Anderson H Kuo, Cun Li, Hillary F Huber, Geoffrey D Clarke, Peter W Nathanielsz
Maternal nutrient reduction induces intrauterine growth restriction (IUGR), increasing risks of chronic diseases later in life, including cardiovascular dysfunction. Using ultrasound, we determined regional blood flow, blood vessels sizes, and distensibility in IUGR baboons (8M/8F, 8.8 years, similar to 35 human years) and controls (12M/12F, 9.5 years). The measured blood vessels were larger in size in the males compared to females before but not after normalization to body surface area. Smaller IUGR normalized blood vessel sizes were observed in the femoral and external iliac arteries but not the brachial or common carotid arteries and not correlated significantly with birth weight...
November 3, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/29094358/messing-with-metabolism-lessons-from-an-iugr-fetus
#8
Sarah J Chapple, Giovanni E Mann
A wealth of evidence supports the developmental period as being an important determinant for future health status, as well as life expectancy. This article is protected by copyright. All rights reserved.
November 1, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/29092053/mining-dna-methylation-alterations-towards-a-classification-of-placental-pathologies
#9
Samantha L Wilson, Katherine Leavey, Brian Cox, Wendy P Robinson
Placental health is a key component to a successful pregnancy. Placental insufficiency (PI), inadequate nutrient delivery to the fetus, is associated with preeclampsia (PE), a maternal hypertensive disorder, and intrauterine growth restriction (IUGR), pathologically poor fetal growth. PI is more common in early-onset PE (EOPE) than late-onset PE (LOPE). However, the relationship between these disorders remains unclear. While DNA methylation (DNAm) alterations have been identified in PE and IUGR, these entities can overlap and few studies have analyzed them separately...
October 30, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/29082786/the-mediterranean-diet-adherence-by-pregnant-women-delivering-prematurely-association-with-size-at-birth-and-complications-of-prematurity
#10
Elisavet Parlapani, Charalampos Agakidis, Thomais Karagiozoglou-Lampoudi, Kosmas Sarafidis, Eleni Agakidou, Apostolos Athanasiadis, Elisavet Diamanti
BACKGROUND: The Mediterranean diet (MD) is associated with decreased risk of metabolic syndrome and gestational diabetes due to the anti-inflammatory and antioxidative properties of its components. The aim was to investigate the potential association of MD adherence (MDA) during pregnancy by mothers delivering prematurely, with intrauterine growth as expressed by neonates' anthropometry at birth and complications of prematurity. PARTICIPANTS AND METHODS: This is a single-center, prospective, observational cohort study of 82 women who delivered preterm singletons at post conceptional age (PCA) ≤ 34 weeks and their live-born neonates...
October 29, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29072695/glucocorticoid-mediates-prenatal-caffeine-exposure-induced-endochondral-ossification-retardation-and-its-molecular-mechanism-in-female-fetal-rats
#11
Yangfan Shangguan, Hongqiang Jiang, Zhengqi Pan, Hao Xiao, Yang Tan, Kai Tie, Jun Qin, Yu Deng, Liaobin Chen, Hui Wang
Our previous studies discovered that prenatal caffeine exposure (PCE) could induce intrauterine growth retardation (IUGR) and long-bone dysplasia in offspring rats, accompanied by maternal glucocorticoid over-exposure. This study is to explore whether intrauterine high glucocorticoid level can cause endochondral ossification retardation and clarify its molecular mechanism in PCE fetal rats. Pregnant Wistar rats were intragastrically administered 30 and 120 mg/kg day of caffeine during gestational days (GDs) 9-20, then collected fetal serum and femurs at GD20...
October 26, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29064795/the-impact-of-emergent-infections-on-the-fetal-state
#12
Liudmyla A Vygivska, Iryna O Tuchkina, Violetta B Kalnytska
THE AIM: To study the impact of emergent infections (human herpesvirus type 6) on the fetal state. MATERIALS AND METHODS: The study involved examination of 90 pregnant women in the 2nd and 3rd trimesters of gestation (Group 1 (25 pregnant) consisted of patients with a viral infection, CMV carriers, Group 2 (25 pregnant) included women with a viral infection, herpes simplex virus types 1/2, Group 3 amounted for 20 patients with a viral infection, herpes simplex virus type 6, Group 4 comprised 20 patients with normal pregnancy and no signs of infection...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29062003/maternal-glucocorticoid-elevation-and-associated-fetal-thymocyte-apoptosis-are-involved-in-immune-disorders-of-prenatal-caffeine-exposed-offspring-mice
#13
Han-Xiao Liu, Ting Chen, Xiao Wen, Wen Qu, Sha Liu, Hui-Yi Yan, Li-Fang Hou, Jie Ping
Our previous study showed that prenatal caffeine exposure (PCE) could induce intrauterine growth retardation (IUGR) and glucocorticoid elevation in the fetus. Researchers suggested that IUGR is a risk factor for T helper cell (Th)1/Th2 deviation. However, whether PCE can induce these immune disorders and the underlying mechanisms of that induction remain unknown. This study aimed to observe the effects of PCE on the Th1/Th2 balance in offspring and further explore the developmental origin mechanisms from the perspective of glucocorticoid overexposure-induced thymocyte apoptosis...
October 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29046106/expression-of-von-willebrand-factor-and-caldesmon-in-the-placental-tissues-of-pregnancies-complicated-with-intrauterine-growth-restriction
#14
Hale Göksever Çelİk, Mehmet Uhrİ, Gökhan Yildirim
PURPOSE: The decreased placental perfusion is the underlying reason for intrauterine growth restriction that in turn leads to reduced placental perfusion and ischemia. However, there are several issues to be understood in the pathophysiology of intrauterine growth restriction. We aimed to study whether any compensatory response in placental vascular bed occur in pregnancies complicated with intrauterine growth restriction by the immunohistochemical staining of von Willebrand factor and caldesmon in placental tissues...
October 18, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29038017/fetal-growth-interacts-with-multilocus-genetic-score-reflecting-dopamine-signaling-capacity-to-predict-spontaneous-sugar-intake-in%C3%A2-children
#15
Patrícia P Silveira, Irina Pokhvisneva, Hélène Gaudreau, Leslie Atkinson, Alison S Fleming, Marla B Sokolowski, Meir Steiner, James L Kennedy, Laurette Dubé, Robert D Levitan, Michael J Meaney
BACKGROUND: We have shown that intrauterine growth restriction (IUGR) leads to increased preference for palatable foods at different ages in both humans and rodents. In IUGR rodents, altered striatal dopamine signaling associates with a preference for palatable foods. OBJECTIVES: Our aim was to investigate if a multilocus genetic score reflecting dopamine-signaling capacity is differently associated with spontaneous palatable food intake in children according to the fetal growth status...
January 1, 2018: Appetite
https://www.readbyqxmd.com/read/29037560/application-of-non-invasive-prenatal-testing-in-late-gestation-in-a-pregnancy-associated-with-intrauterine-growth-restriction-and-trisomy-22-confined-placental-mosaicism
#16
Chih-Ping Chen, Chris Tsai, Ming-Huei Lin, Schu-Rern Chern, Shin-Wen Chen, Shih-Ting Lai, Wen-Lin Chen, Chen-Wen Pan, Wayseen Wang
OBJECTIVE: We present the application of non-invasive prenatal testing (NIPT) in late gestation in a pregnancy associated with intrauterine growth restriction (IUGR) and trisomy 22 confined placental mosaicism (CPM). CASE REPORT: A 35-year-old pregnant woman underwent chorionic villus sampling (CVS) at 12 weeks of gestation. The pregnancy was conceived by in vitro fertilization and intracytoplasmic sperm injection. CVS revealed a karyotype of 47,XY,+22 in all of 15 cultured chorionic villi cells...
October 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29037170/multidisciplinary-consensus-on-screening-for-diagnosis-and-management-of-fetal-growth-restriction-in-the-netherlands
#17
Viki Verfaille, Ank de Jonge, Lidwine Mokkink, Myrte Westerneng, Henriëtte van der Horst, Petra Jellema, Arie Franx
BACKGROUND: Screening for, diagnosis and management of intrauterine growth restriction (IUGR) is often performed in multidisciplinary collaboration. However, variation in screening methods, diagnosis and management of IUGR may lead to confusion. In the Netherlands two monodisciplinary guidelines on IUGR do not fully align. To facilitate effective collaboration between different professionals in perinatal care, we undertook a Delphi study with uniform recommendations as our primary result, focusing on issues that are not aligned or for which specifications are lacking in the current guidelines...
October 16, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29031540/maternal-uterine-artery-vegf-gene-therapy-for-treatment-of-intrauterine-growth-restriction
#18
Anna L David
Intrauterine growth restriction (IUGR) is a serious pregnancy complication affecting approximately 8% of all pregnancies. The aetiology is believed to be insufficient maternal uteroplacental perfusion which prevents adequate nutrient and oxygen availability for the fetus. There is no treatment that can improve uteroplacental perfusion and thereby increase fetal growth in the uterus. Maternal uterine artery gene therapy presents a promising treatment strategy for IUGR, with the use of adenoviral vectors encoding for proteins such as Vascular Endothelial Growth Factor (VEGF) demonstrating improvements in fetal growth and neonatal outcome in preclinical studies...
November 2017: Placenta
https://www.readbyqxmd.com/read/29030147/-report-from-the-cfef-seminar-on-fetal-biometry-june-2017
#19
Collège Français d'échographie Fœtale Cfef
This article reports the conclusions and recommendations resulting from the seminar organized in Paris on June 15, 2017 by the scientific committee of the French College of Fetal Ultrasound (CFEF). The purpose of this meeting was to audit the practices in screening for SGA and IUGR fetuses in France and to discuss ways to improve ultrasound screening. A review of charts, references, standards and common practices was performed. The potential new biometric tools applicable in France were reviewed and analyzed...
October 10, 2017: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/29023467/dietary-lactoferrin-supplementation-to-gilts-during-gestation-and-lactation-improves-pig-production-and-immunity
#20
Marefa Jahan, Susie Kracht, Yen Ho, Ziaul Haque, Birendra N Bhattachatyya, Peter C Wynn, Bing Wang
Lactoferrin (LF), a sialylated iron-binding glycoprotein, performs multiple beneficial functions including modulating immunity and improves neurodevelopment, health and growth performance. Maternal LF intervention for gilts (first parity sows) on the performance of gilts and their offspring remains unknown. In the current study gilts were fed with a commercial pig feed supplemented with 1g LF /day (treatment group) or 1g milk casein/day (control group) from day 1 post mating throughout pregnancy and lactation for about 135 days...
2017: PloS One
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