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histology of thyroiditis

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https://www.readbyqxmd.com/read/29160163/cancer-risk-associated-with-nuclear-atypia-in-cytologically-indeterminate-thyroid-nodules-a-systematic-review-and-meta-analysis
#1
Pablo Valderrabano, Laila Khazai, Zachary J Thompson, Susan C Sharpe, Valentina D Tarasova, Kristen J Otto, Julie E Hallanger-Johnson, J Trad Wadsworth, Bruce M Wenig, Christine H Chung, Barbara A Centeno, Bryan McIver
BACKGROUND: Indeterminate categories of thyroid cytopathology (categories B-III and B-IV of the Bethesda system) are integrated by a heterogeneous spectrum of cytological scenarios that are generally clustered for analysis and management recommendations. It has been suggested that aspirates exhibiting nuclear atypia have a higher risk of malignancy. We assess whether cytologically indeterminate thyroid nodules with nuclear atypia have a significantly higher cancer risk than those without nuclear atypia...
November 21, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29156995/combined-repeated-dose-and-reproductive-developmental-toxicity-screening-test-of-benzene-1-1-oxybis-tetrapropylene-derivs-in-rats
#2
Yasuhiro Tsubokura, Ryuichi Hasegawa, Sunao Aso, Toshio Kobayashi, Takayuki Koga, Satsuki Hoshuyama, Yutaka Oshima, Katsumi Miyata, Yuji Kusune, Takako Muroi, Naoki Hashizume, Yoshiyuki Inoue, Shozo Ajimi, Kotaro Furukawa
We have conducted animal toxicity tests of chemicals for a chemical safety program implemented by the Ministry of Economy, Trade and Industry of Japan. Here we conducted a combined repeated-dose and reproductive/developmental toxicity screening test of benzene, 1,1'-oxybis-, tetrapropylene derivs. (BOTD). BOTD was administered to 9-week-old Crl:CD(SD) male and female rats by gavage at 0, 40, 200, or 1000 mg/kg/day. Males were treated for 42 days including mating period. Females were treated for 42-53 days through the premating, mating, pregnancy, and until Day 4 of lactation periods...
November 20, 2017: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/29154377/tall-cell-variant-of-papillary-breast-carcinoma-an-additional-case-with-review-of-the-literature
#3
A Pitino, S Squillaci, C Spairani, P C Rassu, M F Cosimi
Papillary lesions of the breast can be one of the most challenging aspects of mammary pathology because of a wide morphologic spectrum that may be encountered in these lesions. An unusual breast tumor has been first classified as "breast tumor resembling the tall cell variant of papillary thyroid carcinoma" and subsequently renamed "tall cell variant of papillary breast carcinoma". To our knowledge, only 13 cases of this neoplasm have been reported so far. Metastasis to the breast is not an uncommon event and about 5% of all such cases are of the thyroid origin...
September 2017: Pathologica
https://www.readbyqxmd.com/read/29151299/eleven-patients-with-primary-thyroid-lymphoma-a-single-center-experience
#4
Hasan Bostancı, Kürşat Dikmen, Nalan Akyürek, Ahmet Çağrı Büyükkasap, Aydın Yavuz, Mehmet Muhittin Yalçın, Murat Akın
Background/aim: Primary thyroid lymphoma (PTL) is a very rare thyroid malignancy. It should be diagnosed and treated immediately and accurately. Our aim was to evaluate the diagnostic methods and treatment results for patients with PTL.Materials and methods: We retrospectively evaluated the records of 11 patients with PTL from 2009 to 2015, diagnosed at our institute. Age, sex, stage, histopathologic type, presence of Hashimoto's thyroiditis, diagnostic methods, treatment types, and recurrence were examined...
November 13, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29150742/associations-between-nucleus-size-and-immunohistochemical-galectin-3-cytokeratine-19-and-hbme-1-markers-in-thyroid-papillary-carcinoma-a-morphometric-analyze
#5
Hatice Toy, Ozlem Etli, Zeliha Esin Celik, Arsenal Sezgin Alikanoglu
This study aimed to evaluate the morphometric measurements in cases with papillary thyroid carcinoma, and determine a cut-off value to support diagnosis. Fifty cases with a diagnosis of papillary thyroid carcinoma (PTC) were included in the study with their Galectine-3, CK-19 and HBME-1 immunohistochemical staining results. Demographic and clinical data gathered from pathology reports, which included demographic information such as patients' sex, age, macroscopic tumor size, number of tumor focuses; prognostic parameters such as lenfovascular invasion, perineural invasion, thyroid capsule invasion; and results of immunohistochemical CK- 19, Galectin-3 and HBME-1 staining...
November 17, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/29144811/concordance-of-preoperative-clinical-stage-with-pathological-stage-in-patients-%C3%A2-45-years-with-well-differentiated-thyroid-cancer
#6
Natalie A Calcatera, Waseem Lutfi, Paritosh Suman, Nicholas R Suss, Chi-Hsiung Wang, Richard A Prinz, David J Winchester, Tricia A Moo-Young
OBJECTIVE: Clinical stage (cStage) in thyroid cancer determines extent of surgical therapy and completeness of resection. Pathologic stage (pStage) is an important determinant of outcome. The rate of discordance between clinical and pathologic stage in thyroid cancer is unknown. METHODS: The National Cancer Data Base (NCDB) was queried to identify 27,473 patients ≥45 years old with cStage I through IV differentiated thyroid cancer undergoing surgery from 2008-2012...
November 16, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29144798/pancreas-metastases-from-papillary-thyroid-carcinoma-a-review-of-the-literature
#7
Maja Davidson, Randall J Olsen, April A Ewton, Richard J Robbins
OBJECTIVE: Although loco-regional metastases occur in 5-10% of patients with papillary thyroid cancer (PTC), distant metastases are rare, especially to the pancreas. Here we review the literature regarding metastases to the pancreas from PTC and present an illustrative patient. METHODS: The literature search was performed through www.pubmed.org . The information regarding our illustrative case was obtained from the medical records of our institution. RESULTS: Since 1991, 11 cases of pancreas metastases of PTC have been reported...
November 16, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29142854/skin-metastasis-on-the-neck-an-unusual-presentation-of-recurrence-of-papillary-thyroid-carcinoma
#8
Selen Soylu, Akif Enes Arikan, Serkan Teksoz, Murat Ozcan, Yusuf Bukey
Skin metastasis of papillary thyroid carcinoma (PTC) is rare. Here, two cases of skin metastases of PTC are presented. Both of the patients were females, one is 83 and the other is 65 years old. The patients were admitted to the hospital with a movable skin lesion on anterior neck region. Free T3 and T4 levels were in normal levels and TSH levels were low in both patients. The 83-year-old patient underwent total thyroidectomy due to papillary thyroid cancer and received (131)I ablation therapy and then thyroid suppression therapy...
October 2017: Gland Surgery
https://www.readbyqxmd.com/read/29139221/evaluation-of-hypothalamus-pituitary-thyroid-axis-function-by-chronic-perchlorate-exposure-in-male-rats
#9
Caroline Serrano-Nascimento, Jamile Calil-Silveira, Rafael Dalbosco, Telma Tenorio Zorn, Maria Tereza Nunes
Perchlorate is a widespread endocrine disruptor that was previously correlated with increased serum TSH levels and decreased thyroid hormones production both in animals and humans. Even so, the regulation of gene/protein expression in the hypothalamus, pituitary and thyroid by chronic perchlorate exposure was not completely elucidated. Therefore, this study aimed to investigate the underlying mechanisms involved in the disruption of hypothalamus-pituitary-thyroid axis by chronic perchlorate exposure. Male Wistar rats were treated or not with NaClO4 in the drinking water (35 mg/Kg/day) for 60 days...
November 15, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/29137037/a-case-report-of-recurrent-thyroid-inflammatory-myofibroblastic-tumor-and-its-metastasis-in-soft-tissue
#10
Jiajia Duan, Ying Wang
RATIONALE: Inflammatory myofibroblastic tumor (IMT) is a neoplasm of low malignant potential. The most frequent site of IMT is in the lung, whereas recurrent and metastasis of thyroid IMT has been seldom reported. PATIENT CONCERNS: A 57-year-old male presented with a 3-year history of painless thyroid mass. The physical examination revealed a diffusely enlarged thyroid which was firm. The thyroid function and antibodies were normal. Thyroid ultrasound revealed a hypoechoic mass in the left lobe and heterogeneous echo in the right lobe...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29137018/rare-metastasis-of-nasopharyngeal-carcinoma-to-the-thyroid-gland-with-subsequent-metastatic-abdominal-lymph-nodes-a-case-report-and-literature-review
#11
Changjing Cai, Hong Shen, Wenqiang Liu, Junli Ma, Yan Zhang, Ling Yin, Jindong Li, Liangfang Shen, Shan Zeng
RATIONALE: Thyroid metastasis from nasopharyngeal carcinoma is rare. Metastasis of nasopharyngeal carcinoma to the thyroid gland with subsequent metastatic abdominal lymph nodes hasn't been reported before. We want to share our experience about the treatment choice. PATIENT CONCERNS: A 27-year-old man was diagnosed with nasopharyngeal nonkeratinizing carcinoma in August 2004. In March 2013 he underwent a thyroid carcinoma radical operation, and histological examination revealed metastasis to the thyroid gland from nasopharyngeal carcinoma...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29136676/papillary-thyroid-cancer-and-coexisting-autoimmune-thyroiditis
#12
Franziska Veit, Dieter Graf, Saskia Momberger, Brigitte Helmich-Kapp, Ilka Ruschenburg, Anja Peters, Jochen Kussmann, Wolfgang Saeger, Kurt Werner Schmidt, Martin Toetsch, Kai Nestler, Klaus Mann
Histological findings often display an association between papillary thyroid carcinomas (PTC) and autoimmune thyroiditis (AIT) and so differ significantly from follicular thyroid carcinomas (FTC). The aim of this interdisciplinary, retrospective study was to evaluate the association of AIT in patients with PTC and FTC and a control group of benign nodular goiters. One hundred thyroidectomies with histologically confirmed differentiated thyroid carcinomas, 67 with PTC and 33 with FTC, were submitted for examination...
November 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29133385/targeted-next-generation-sequencing-of-cancer-genes-in-poorly-differentiated-thyroid-cancer
#13
Tiemo S Gerber, Arno Schad, Nils Hartmann, Erik Springer, Ulrich Zechner, Thomas J Musholt
Poorly differentiated thyroid carcinoma (PDTC) is a rare malignancy with higher mortality than well-differentiated thyroid carcinoma. The histological diagnosis can be difficult as well as the therapy. Improved diagnosis and new targeted therapies require knowledge of DNA sequence changes in cancer-relevant genes. The TruSeq Amplicon Cancer Panel was used to screen cancer genomes from 25 PDTC patients for somatic single nucleotide variants in 48 genes known to represent mutational hotspots. A total of 4490 variants were found in 23 tissue samples of PDTC...
November 13, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/29130950/characteristics-of-false-negative-thyroid-fine-needle-aspirates
#14
Andrew A Renshaw, Edwin W Gould
INTRODUCTION: False-negative thyroid fine-needle aspirates (FNA) are not well characterized. METHODS: We correlated the results of all thyroid aspirations from 1997 to 2016 with histologic follow-up. RESULTS: There were 13,733 aspirates, 2,112 (15.3%) resections, and 678 malignancies (32.1%). Eighteen (2.7%) false-negative cases were identified (interpretation, n = 6; sampling, n = 7; and new nodules, n = 5). Interpretive false-negative cases were significantly less likely when the indeterminate rate was greater than 13% (p = 0...
November 4, 2017: Acta Cytologica
https://www.readbyqxmd.com/read/29128185/correct-extent-of-thyroidectomy-is-poorly-predicted-preoperatively-by-the-guidelines-of-the-american-thyroid-association-for-low-and-intermediate-risk-thyroid-cancers
#15
Mashaal Dhir, Kelly L McCoy, N Paul Ohori, Cameron D Adkisson, Shane O LeBeau, Sally E Carty, Linwah Yip
BACKGROUND: Recent guidelines from the American Thyroid Association recommend thyroid lobectomy for intrathyroidal differentiated thyroid cancers <4 cm. Our aim was to examine histology from patients with cytologic results that were positive or suspicious for malignancy to assess the extent of initial thyroidectomy based on criteria from the 2015 American Thyroid Association guidelines. METHODS: We studied consecutive patients who had either a positive or suspicious for malignancy cytologic diagnosis and under prior American Thyroid Association guidelines underwent initial total thyroidectomy ± lymphadenectomy...
November 8, 2017: Surgery
https://www.readbyqxmd.com/read/29126198/thyroid-hormone-receptor-%C3%AE-and-%C3%AE-knockout-xenopus-tropicalis-tadpoles-reveal-subtype-specific-roles-during-development
#16
Keisuke Nakajima, Ichiro Tazawa, Yoshio Yaoita
Thyroid hormone (TH) binds TH receptor alpha (TRα) and beta (TRβ) receptors to induce amphibian metamorphosis. Whereas TH signalling has been well studied, functional differences between TRα and TRβ during this process have not been characterized. To understand how each TR contributes to metamorphosis, we generated TRα- and TRβ-knockout tadpoles of Xenopus tropicalis and examined developmental abnormalities, histology of the tail and intestine, and mRNA expression of genes encoding extracellular matrix (ECM)-degrading enzymes...
November 3, 2017: Endocrinology
https://www.readbyqxmd.com/read/29124480/a-case-of-napsin-a-positive-metastatic-lung-cancer-originating-from-the-colon
#17
Tomokazu Ito, Kozo Nakanishi, Hidenori Goto
BACKGROUND: We report a case of napsin A-positive metastatic lung cancer originating from the colon. No cases of napsin A-positive metastatic lung tumors originating from colorectal cancer have been reported previously. CASE PRESENTATION: Computed tomography identified a small lung nodule in a 70-year-old male patient, 18 months after resection for rectal cancer. The size of the lung tumor increased from 1.8 to 2.1 cm in 6 months and metastasis from the rectal cancer was suspected...
November 9, 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/29124354/parathyroid-thyroid-and-recurrent-laryngeal-nerve-anatomy-in-an-indian-rhinoceros-rhinoceros-unicornis
#18
R Udelsman, S B Citino, M Prasad, P I Donovan, D V Fredholm
INTRODUCTION: The parathyroid gland was first identified in the Indian rhinoceros in 1849 by Sir Richard Owen. We performed a necropsy in an Indian rhinoceros, recapitulating Owen's dissection and display what appear to be the initial identification of the recurrent laryngeal nerve in situ and the anatomy and histology of the largest rhinoceros parathyroid glands yet identified. MATERIALS AND METHODS: Patrick T. Rhino, a 41-year-old Indian rhinoceros was born in 1974...
November 9, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29118988/atypical-manifestation-of-parathyroid-carcinoma-with-late-onset-distant-metastases
#19
Marina Tsoli, Anna Angelousi, Dimitra Rontogianni, Constantine Stratakis, Gregory Kaltsas
Parathyroid carcinoma is an extremely rare endocrine malignancy that accounts for less than 1% of cases of primary hyperparathyroidism. We report a 44-year-old woman who presented with fatigue and diffuse bone pain. Laboratory findings revealed highly elevated serum calcium and parathyroid hormone (PTH) levels and a 4.5 × 3 × 2.5 cm cystic lesion in the lower pole of the right thyroid lobe that was shown histologically to be a parathyroid carcinoma. Ten years later, the patient developed brain and pulmonary metastases and recurrence of PTH-related hypercalcemia...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29118474/cytological-evaluation-of-thyroid-lesions-by-nuclear-morphology-and-nuclear-morphometry
#20
R Yashaswini, T N Suresh, A Sagayaraj
Introduction: Fine needle aspiration (FNA) of the thyroid gland is an effective diagnostic method. The Bethesda system for reporting thyroid cytopathology classifies them into six categories and gives implied risk for malignancy and management protocol in each category. Though the system gives specific criteria, diagnostic dilemma still exists. Using nuclear morphometry, we can quantify the number of parameters, such as those related to nuclear size and shape. The evaluation of nuclear morphometry is not well established in thyroid cytology...
October 2017: Journal of Cytology
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