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Thomas P Karbanowicz, Amanda Nouwens, Ala E Tabor, Manuel Rodriguez-Valle
Tick populations are controlled through the application of chemical pesticides. However, the rise in chemical resistance has prompted the investigation of other control methods such as the use of tick vaccines. Proteomic analysis provides valuable information about the possible function and localization of proteins, as candidate vaccine proteins are often either secreted or localized on the cell-surface membrane. Progress in the utilization of proteomics for the identification of novel treatment targets has been significant...
March 14, 2018: Veterinary Sciences
Eiichiro Amano, Kokoro Ozaki, Satoru Egawa, Motohiro Suzuki, Takashi Hirai, Satoru Ishibashi, Takuya Ohkubo, Toshitaka Yoshii, Atsushi Okawa, Takanori Yokota
RATIONALE: OSAM is a rare ventriculoperitoneal (VP) shunt complication where cervical spinal cord compression by epidural venous plexus engorgement is caused by cerebrospinal fluid (CSF) overdrainage. Symmetrically indented deformity of the upper cervical spinal cord and surrounding epidural venous engorgement are characteristic radiological findings. Both of them are typically detected on magnetic resonance imaging (MRI) and enhanced computed tomography (CT). PATIENT CONCERNS: The 77-year-old man who underwent the placement of a VP shunt without an antisiphon device to treat post-subarachnoid hemorrhage (SAH) hydrocephalus presented with progressive quadriplegia 10 years postoperatively...
March 2018: Medicine (Baltimore)
Djane Clarys Baia-da-Silva, Luis Carlos Salazar Alvarez, Omaira Vera Lizcano, Fabio Trindade Maranhão Costa, Stefanie Costa Pinto Lopes, Alessandra Silva Orfanó, Denner Oliveira Pascoal, Rafael Nacif-Pimenta, Iria Cabral Rodriguez, Maria das Graças Vale Barbosa Guerra, Marcus Vinicius Guimarães Lacerda, Nagila Francinete Costa Secundino, Wuelton Marcelo Monteiro, Paulo Filemon Paolucci Pimenta
BACKGROUND: Plasmodium vivax is predominant in the Amazon region, and enhanced knowledge of its development inside a natural vector, Anopheles aquasalis, is critical for future strategies aimed at blocking parasite development. The peritrophic matrix (PM), a chitinous layer produced by the mosquito midgut in response to blood ingestion, is a protective barrier against pathogens. Plasmodium can only complete its life-cycle, and consequently be transmitted to a new host, after successfully passing this barrier...
March 6, 2018: Parasites & Vectors
Emilie Bouhsira, Katrin Deuster, Emmanuel Lienard, Christophe Le Sueur, Michel Franc
BACKGROUND: Two laboratory experiments (Studies 1 and 2) were conducted to confirm the efficacy of an imidacloprid and permethrin combination (Advantix® Spot-on, Bayer) to repel and kill Phlebotomus (Larroussius) perniciosus sand flies when applied once a month topically to dogs. METHODS: Both studies compared dogs treated with a combination containing 100 mg/ml imidacloprid + 500 mg/ml permethrin (Advantix® Spot-on, Bayer) to placebo treated dogs. The treatments were applied topically on Day -28 (Study 2) and Day 0 (Studies 1 and 2)...
March 2, 2018: Parasites & Vectors
J D Charlwood, E Kessy, K Yohannes, N Protopopoff, M Rowland, C LeClair
The relative efficacy of a mechanical (Prokopack) collection method vs. manual aspiration in the collection of resting mosquitoes was evaluated in northern Tanzania before and after an intervention using indoor residual spraying and longlasting insecticide-treated nets. In smoke-free houses mosquitoes were collected from the roof and walls, but in smoky houses mosquitoes were found predominantly on the walls. Anopheles gambiae (Diptera: Culicidae) constituted 97.7% of the 312 An. gambiae complex specimens identified before but only 19...
February 26, 2018: Medical and Veterinary Entomology
Roland Eric Yessinou, Yao Akpo, Aboubakar Sidick, Camus Adoligbe, Issaka Youssao Abdou Karim, Martin Akogbeto, Souaïbou Farougou
Ticks are obligate haematophagous arthropods, causing heavy losses in affected livestock. The objective of this study is to investigate phenotypic and genotypic resistance in Rhipicephalus microplus populations from Benin. Engorged female adult ticks were collected from cattle in two districts of Benin. Bioassays, biochemical and molecular tests were carried out on these ticks to determine the phenotypic, enzymatic and genetic status of resistance. Results of bioassays showed high resistance factors (RF > 41)...
February 16, 2018: Ticks and Tick-borne Diseases
Lance A Durden, Robert F Gerlach, Kimberlee B Beckmen, Stephen E Greiman
Ixodes angustus (Neumann) (Acari: Ixodidae) is considered to be a nidicolous tick in that the entire life cycle can be completed in the host nest. Males of this tick have been reported to be rare on hosts because most mating occurs in the host nest and males typically do not feed on hosts. Collections of I. angustus in Alaska departed slightly from this paradigm in that nine males were collected from hosts, mostly in copulation with females that were attached to mammalian hosts. Non-nidicolous mating was therefore more common in I...
February 19, 2018: Journal of Medical Entomology
André de Abreu Rangel Aguirre, Vinicius da Silva Rodrigues, Ivaneide Nunes da Costa, Marcos Valerio Garcia, Leandro de Oliveira Souza Higa, Jansen Fernandes Medeiros, Renato Andreotti
One generation of Amblyomma coelebs life cycle under experimental conditions was evaluated. Ten tick pairs were allowed to feed on rabbits under laboratory conditions (LC), resulting six engorged females with a mean weight of 1,403.9 mg. Two females were maintained in a forest reserve under natural conditions (NC), and four were maintained in incubators (LC). The engorgement period lasted 10.33 days. Pre-oviposition periods were 10.75 (NC) and 22 days (LC). The mean egg-mass weight was 514.76 mg, and the blood meal conversion index was 36...
February 19, 2018: Revista Brasileira de Parasitologia Veterinária, Brazilian Journal of Veterinary Parasitology
Chongxing Zhang, Guihong Shi, Peng Cheng, Lijuan Liu, Maoqing Gong
Background & objectives: Anopheles sinensis Wiedemann is a major vector of malaria and is among the dominant species in Shandong province of China. Knowledge of the blood-feeding patterns of mosquitoes is crucial for elimination of malaria vectors. However, little information is available on the blood-feeding behaviour of An. sinensis mosquitoes in Shandong province. This study was carried out to compare the blood-feeding behaviour of An. sinensis in malaria-endemic areas of Shandong province China...
October 2017: Journal of Vector Borne Diseases
Yen-Heng Lin, Chung-Wei Lee, Yu-Fen Wang, Chi-Ju Lu, Ya-Fang Chen, Hon-Man Liu
BACKGROUND AND PURPOSE: Engorged medullary vein (EMV) in patients with intracranial dural arteriovenous fistula (DAVF) suggests venous congestion. The aim of this study is to investigate its prevalence, pattern, and correlation with clinical findings. MATERIALS AND METHODS: CT angiography (CTA) raw data of DAVF were used for multiplanar reconstruction and then analyzed for the presence and pattern of EMV, which is defined as a dilated vein in the cerebral white matter...
February 19, 2018: Journal of Neurointerventional Surgery
Agustin Fernández-Salas, Miguel Angel Alonso Díaz, Rogelio Alejandro Alonso Morales, Roberto Lezama-Gutierrez, José Antonio Cervantes-Chávez
The objectives of the present study were to isolate Beauveria bassiana strains from cattle farms soils, to analyze the phylogenetic relationships among the isolated fungi strains, and to determine the acaricidal effect of B. bassiana isolates on Rhipicephalus microplus engorged ticks, resistant or susceptible to chemical acaricides. Six strains of Beauveria bassiana were obtained and isolated from cattle farms soils by Galleria bait method in Mexican tropics and the acaricidal effect was assessed against 2 populations of R...
February 19, 2018: Journal of Parasitology
Basma El Hamzaoui, Maureen Laroche, Lionel Almeras, Jean Michel Bérenger, Didier Raoult, Philippe Parola
BACKGROUND: Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS) has recently emerged in the field of entomology as a promising method for the identification of arthropods and the detection of associated pathogens. METHODOLOGY/PRINCIPAL FINDINGS: An experimental model of Ctenocephalides felis (cat fleas) infected with Bartonella quintana and Bartonella henselae was developed to evaluate the efficacy of MALDI-TOF MS in distinguishing infected from uninfected fleas, and its ability to distinguish fleas infected with Bartonella quintana from fleas infected with Bartonella henselae...
February 16, 2018: PLoS Neglected Tropical Diseases
Guofu Shen, Schuyler Link, Sandeep Kumar, Derek M Nusbaum, Dennis Y Tse, Yingbin Fu, Samuel M Wu, Benjamin J Frankfort
Elevated intracranial pressure (ICP) can result in multiple neurologic sequelae including vision loss. Inducible models of ICP elevation are lacking in model organisms, which limits our understanding of the mechanism by which increased ICP impacts the visual system. We adapted a mouse model for the sustained elevation of ICP and tested the hypothesis that elevated ICP impacts the optic nerve and retinal ganglion cells (RGCs). ICP was elevated and maintained for 2 weeks, and resulted in multiple anatomic changes that are consistent with human disease including papilledema, loss of physiologic cupping, and engorgement of the optic nerve head...
February 12, 2018: Scientific Reports
Emmanuel Pacia Hernandez, Kodai Kusakisako, Melbourne Rio Talactac, Remil Linggatong Galay, Takeshi Hatta, Tomohide Matsuo, Kozo Fujisaki, Naotoshi Tsuji, Tetsuya Tanaka
BACKGROUND: Ticks are obligate hematophagous parasites important economically and to health. Ticks consume large amounts of blood for their survival and reproduction; however, large amounts of iron in blood could lead to oxidative stress. Ticks use several molecules such as glutathione S-transferases (GSTs), ferritins, and peroxiredoxins to cope with oxidative stress. This study aimed to identify and characterize the GSTs of the hard tick Haemaphysalis longicornis in order to determine if they have a role in coping with oxidative stress...
February 8, 2018: Parasites & Vectors
Lei Liu, Yi-Song Liu, Guo-Hua Liu, Tian-Yin Cheng
BACKGROUND: Ticks and tick-borne diseases are of major public health concern. Currently, development of vaccines against ticks is considered crucial for their control. A critical step in this process is the screening of viable antigens. Faeces are byproducts of digestion and blood meal utilization, and partly reflect the vitality and vector potential of ticks. However, an integrated analysis of proteins in tick faeces is lacking. The present study explored the protein components in the faeces of the tick Haemaphysalis flava, by liquid chromatography-tandem mass spectrometry (LC/MS-MS) to identify potential protein antigens for vaccine development against ticks...
February 8, 2018: Parasites & Vectors
Kyung Eun Han, Sangchul Yoon, Roo Min Jun, Tae-Im Kim, Eung Kweon Kim, Kyoung Yul Seo
PURPOSE: To report a new surgical procedure using biodegradable collagen matrix (Ologen) implantation with conjunctival flap for reconstruction of scleromalacia after periocular surgery. METHODS: A total of 26 areas of 25 eyes in 25 patients were included. We divided all eyes according to the preoperative extent of calcified plaque or scleral defect as follows: small, large, and large and severe. Morphologic outcomes were graded from 0 to 7, with higher scores indicating worse cosmetic outcomes...
February 8, 2018: Ocular Immunology and Inflammation
Xin-Yi Liu, Ya-Ting Huang, Min-Yu Lai, John Chen, Tung-Wei Chu, Pei-Kwei Tsay, Chih-Chung Shiao
BACKGROUND: Cardiogenic pulmonary edema (CPE) is a life-threatening emergency necessitating aggressive management. We conducted this study to test the hypothesis that a combination of N-terminal pro-b-type natriuretic peptide (NT-pro-BNP) and some relevant clinical factors may provide better predictability for CPE in heart failure (HF) patients. METHODS: This retrospective study enrolled adult HF patients hospitalized during January 2011 to December 2013. After determining the independent predictors for the occurrence of CPE, a novel NT-pro BNP-based diagnostic score for predicting CPE was established...
February 20, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
Marcelo Francisco Dos Santos, Magna Aparecida Maltauro Soares, Maria Anete Lallo, Darci Moraes Barros-Battesti, Solange de Lima-Netto, Diva Denelle Spadacci-Morena
The Gené's organ (GO) secretes a waxy substance on eggs that reduces water loss and has antimicrobial properties. The current study evaluated morphological and histochemical aspects of GO in Amblyomma sculptum from the period of post-feeding - when ticks detach from the host - to the stage just before oviposition. In this species, GO is composed of a corpus and two pairs of glands, namely, cranial and caudal. Glandular cells are joined laterally by a system of interdigitating membranes with junctional complexes...
January 29, 2018: Ticks and Tick-borne Diseases
Juraj Koci, Quentin Bernard, Xiuli Yang, Utpal Pal
In its natural infection cycle, the pathogen of Lyme borreliosis transits between a tick vector and a mammalian host. As relatively a minor fraction of spirochetes transits between the host and the vector precluding their reliable detection at early infection, artificial membrane feeders emerged as useful tools to study roles of spirochete proteins in pathogen entry, persistence, and exit through ticks. Here we report the development of a modified membrane feeder to study the role of a Borrelia burgdorferi surface protein called Lmp1 in spirochete transitions between the murine host and ticks...
January 30, 2018: Scientific Reports
Aya Zamoto-Niikura, Masayoshi Tsuji, Wei Qiang, Shigeru Morikawa, Ken-Ichi Hanaki, Patricia J Holman, Chiaki Ishihara
Babesia divergens Asia lineage parasites, which are closely related to B. divergens in Europe and Babesia sp. MO1 in the United States, was recently reported in sika deer (Cervus nippon) in eastern Japan. To identify the tick vector(s) for this parasite, we conducted a field survey in Hokkaido, Japan where the infection rate in sika deer is the highest in the country. A specific PCR system which detects and discriminates between lineages within B. divergens and between those lineages and B. venatorum showed that Ixodes persulcatus (11/845), but not sympatric I...
January 26, 2018: Applied and Environmental Microbiology
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