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https://www.readbyqxmd.com/read/28400004/effect-of-food-related-stress-conditions-and-loss-of-agr-and-sigb-on-seb-promoter-activity-in-s-%C3%A2-aureus
#1
Henna-Maria Sihto, Roger Stephan, Christoph Engl, John Chen, Sophia Johler
Staphylococcal enterotoxin B (SEB) causes staphylococcal food poisoning and is produced in up to ten times higher quantities than other major enterotoxins. While Staphylococcus aureus growth is often repressed by competing flora, the organism exhibits a decisive growth advantage under some stress conditions. So far, data on the influence of food-related stressors and regulatory mutations on seb expression is limited and largely based on laboratory strains, which were later reported to harbor mutations. Therefore, the aim of this study was to investigate the influence of stress and regulatory mutations on seb promoter activity...
August 2017: Food Microbiology
https://www.readbyqxmd.com/read/28375940/electrophysiological-studies-to-detect-peripheral-neuropathy-in-children-treated-with-vincristine
#2
Marko Kavcic, Blaz Koritnik, Matevz Krzan, Orjana Velikonja, Tomaz Prelog, Milica Stefanovic, Maruša Debeljak, Janez Jazbec
Patients treated with vincristine predictably develop peripheral neuropathy. The aim of our study was to investigate the pattern of vincristine-induced neuropathy in children by nerve conduction studies and somatosensory-evoked potentials (SSEPs). We included data from 39 children who received vincristine for various pediatric malignancies, and we performed initial and follow-up (after a minimum of 4 doses of vincristine 1.5 mg/m) conduction studies in 27 patients and SSEPs studies in 34 patients. On follow-up the most prevalent symptoms were paresthesias (44%) and constipation (22%), and the most common neurological sign was impaired myotatic reflexes (89%)...
April 3, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28363998/e3-ligase-ciap2-mediates-downregulation-of-mre11-and-radiosensitization-in-response-to-hdac-inhibition-in-bladder-cancer
#3
Judith Nicholson, Sarah Jevons, Blaz Groselj, Sophie Ellermann, Rebecca Konietzny, Martin Kerr, Benedikt M Kessler, Anne E Kiltie
The MRE11/RAD50/NBS1 (MRN) complex mediates DNA repair pathways, including double-strand breaks induced by radiotherapy. Meiotic recombination 11 homolog (MRE11) is downregulated by histone deacetylase inhibition (HDACi), resulting in reduced levels of DNA repair in bladder cancer cells and radiosensitization. In this study, we show that the mechanism of this downregulation is post-translational and identify a C-terminally truncated MRE11, which is formed after HDAC inhibition as full-length MRE11 is downregulated...
March 31, 2017: Cancer Research
https://www.readbyqxmd.com/read/28355437/radiofrequency-exposures-of-workers-on-low-power-fm-radio-transmitters
#4
Blaž Valic, Bor Kos, Peter Gajšek
Low-power radio transmitters are one of the most common radio frequency sources and the exposure limit values (ELVs) for occupational exposure may be exceeded close to them. Therefore, a detailed analysis and assessment of occupational exposure in their vicinity is presented in the paper. For 20 different exposure scenarios, electric field strength and specific absorption rate (SAR) values were computed to determine whether the action levels (ALs) and ELVs of the European directive 2013/35/EU are exceeded for different 500 W radio transmitters...
May 1, 2017: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/28346685/experience-of-shame-mediates-the-relationship-between-pathological-narcissism-and-suicidal-ideation-in-psychiatric-outpatients
#5
Nenad Jaksic, Darko Marcinko, Milena Skocic Hanzek, Blaz Rebernjak, John S Ogrodniczuk
OBJECTIVE: Pathological narcissism, described by 2 dysfunctional phenotypic forms-grandiosity and vulnerability-has often been connected to suicidal tendencies in theoretical and clinical literatures. Furthermore, shame proneness has been implicated as a key mechanism that links these 2 constructs. However, empirical evidence for the presumed relationship between pathological narcissism and suicidal tendencies is sparse, and no prior research has investigated the role of shame proneness in this relationship...
March 27, 2017: Journal of Clinical Psychology
https://www.readbyqxmd.com/read/28339104/transferable-antibiotic-resistances-in-marketed-edible-grasshoppers-locusta-migratoria-migratorioides
#6
Andrea Osimani, Cristiana Garofalo, Lucia Aquilanti, Vesna Milanović, Federica Cardinali, Manuela Taccari, Marina Pasquini, Stefano Tavoletti, Francesca Clementi
Grasshoppers are the most commonly eaten insects by humans worldwide, as they are rich in proteins and micronutrients. This study aimed to assess the occurrence of transferable antibiotic resistance genes in commercialized edible grasshoppers. To this end, the prevalence of 12 selected genes [aac(6')-Ie aph(2″)-Ia, blaZ, erm(A), erm(B), erm(C), mecA, tet(M), tet(O), tet(S), tet(K), vanA, vanB] coding for resistance to antibiotics conventionally used in clinical practice was determined. The majority of samples were positive for tet(M) (70...
March 24, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28322639/the-symbolic-functions-of-nurses-cognitive-artifacts-on-a-medical-oncology-unit
#7
Jacquelyn W Blaz, Alexa K Doig, Kristin G Cloyes, Nancy Staggers
Acute care nurses continue to rely on personally created paper-based tools-their "paper brains"-to support work during a shift, although standardized handoff tools are recommended. This interpretive descriptive study examines the functions these paper brains serve beyond handoff in the medical oncology unit at a cancer specialty hospital. Thirteen medical oncology nurses were each shadowed for a single shift and interviewed afterward using a semistructured technique. Field notes, transcribed interviews, images of nurses' paper brains, and analytic memos were inductively coded, and analysis revealed paper brains are symbols of patient and nurse identity...
December 1, 2016: Western Journal of Nursing Research
https://www.readbyqxmd.com/read/28290267/characterisation-of-penicillin-and-tetracycline-resistance-in-staphylococcus-aureus-isolated-from-bovine-milk-samples-in-minas-gerais-brazil
#8
Caroline L Martini, Carla C Lange, Maria Avp Brito, João B Ribeiro, Letícia C Mendonça, Eliana K Vaz
This Regional Research Communication describes the characterisation of ampicillin, penicillin and tetracycline resistance in Staphylococcus aureus isolated from bovine subclinical mastitis in Minas Gerais State, Brazil. Ninety S. aureus isolates from bovine mastitis exhibiting phenotypic resistance to ampicillin, penicillin and/or tetracycline were selected for this study. The minimum inhibitory concentration (MIC) of each antibiotic was determined using the E-Test® and the production of beta-lactamase was determined by cefinase disks...
March 14, 2017: Journal of Dairy Research
https://www.readbyqxmd.com/read/28250264/methicillin-susceptible-teicoplanin-resistant-staphylococcus-haemolyticus-from-bloodstream-infection-novel-mutation-in-teicoplanin-resistant-operon-tcarab
#9
Yamuna Devi Bakthavatchalam, Thambu David Sudarsanam, Priyanka Babu, Elakkiya Munuswamy, Dhiviya Prabaa Muthuirulandi Sethuvel, Naveen Kumar Devanga Ragupathi, Balaji Veeraraghavan
Staphylococcus haemolyticus is the frequently isolated coagulase-negative staphylococci (CoNS) from blood culture. Here we port a case of methicillin-susceptible S. haemolyticus resistant to teicoplanin and heteroresistant to vancomycin. The isolate was found to susceptible to cefoxitin and resistant to teicoplanin in E-test. PAP-AUC analysis confirmed the presence of vancomycin heteroresistant subpopulation. NGS analysis of the genome revealed the presence of blaZ, msr(A) codes for cross-resistance of macrolide, lincosamide and streptogramin B and quinolone resistance encoding norA gene...
February 28, 2017: Japanese Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28230220/small-molecule-activation-sbf3-auto-ionization-supported-by-transfer-and-mesoionic-nhc-rearrangement
#10
Blaž Alič, Aleš Štefančič, Gašper Tavčar
The reactivity of antimony trifluoride, SbF3, in non-polar aprotic solvents has been unexplored due to its negligible solubility. The reaction of the [SbF3(tmen)] complex (2) with the N-heterocyclic carbene, 1,3-bis(2,6-diisopropylphenyl)imidazole-2-ylidene, (L(Dipp)), probably leads to the formation of a neutral [(L(Dipp))SbF3] intermediate (3) in non-polar solvents. Mild heat treatment of the reaction mixture unexpectedly activates the SbF3 molecules to undergo the auto-ionization reaction. In this process, one of the (L(Dipp)) ligands undergoes rearrangement into the mesoionic carbene (MIC) and further coordinates to the cation to form [(L(Dipp))2SbF2](+)[SbF4](-), product (4)...
February 23, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28135900/penicillin-susceptible-staphylococcus-aureus-susceptibility-testing-resistance-rates-and-outcome-of-infection
#11
Malin Hagstrand Aldman, Annette Skovby, Lisa I Påhlman
BACKGROUND: Staphylococcus aureus (SA) is an important human pathogen that causes both superficial and invasive infections. Penicillin is now rarely used in the treatment of SA infections due to widespread resistance and a concern about the accuracy of existing methods for penicillin susceptibility testing. The aims of the present study were to determine the frequency of penicillin-susceptible SA isolates from blood and wound cultures in Lund, Sweden, and to evaluate methods for penicillin testing in SA...
June 2017: Infectious Diseases
https://www.readbyqxmd.com/read/28109886/truncated-prion-protein-prp226-a-structural-view-on-its-role-in-amyloid-disease
#12
Valerija Kovač, Blaž Zupančič, Gregor Ilc, Janez Plavec, Vladka Čurin Šerbec
In the brain of patients with transmissible spongiform encephalopathies, besides PrP(Sc) aggregates, deposition of truncated PrP molecules was described. Jansen et al. reported two clinical cases with deposition of C-terminally truncated PrP, one of them ending with Tyr226. We have previously described the discovery of monoclonal antibody V5B2 that selectively recognizes this version of the prion protein, which we called PrP226*. Using monoclonal antibody V5B2 we showed that accumulation of PrP226* is characteristic for most types of human and animal TSEs...
January 19, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28087612/biofilm-formation-and-antimicrobial-resistance-genes-of-coagulase-negative-staphylococci-isolated-from-cows-with-mastitis-in-argentina
#13
Mariela E Srednik, Yannick D N Tremblay, Josée Labrie, Marie Archambault, Mario Jacques, Fernández Cirelli Alicia, Elida R Gentilini
Mastitis affects the health and welfare of dairy cows worldwide. Coagulase-negative staphylococci (CNS) are known to form biofilms and are increasingly recognized as a cause of persistent bovine intramammary infections. A total of 90 CNS isolated from cows with clinical and subclinical mastitis in Argentina from 2008-2014 were identified by PCR-RFLP using the gap gene. Standard microtiter plate assays were used to assess CNS biofilm formation and Staphylococcus haemolyticus species formed the strongest biofilms...
January 12, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/28069883/comparison-of-phenotypic-methods-for-the-detection-of-penicillinase-in-staphylococcus-aureus-and-proposal-of-a-practical-diagnostic-approach
#14
Michael Hombach, Christoph Weissert, Maria Magdalena Senn, Reinhard Zbinden
Objectives: Disc diffusion is a cost-efficient, low-complexity, reliable method for detection of blaZ -mediated benzylpenicillin resistance in Staphylococcus aureus if the zone edge is inspected. EUCAST breakpoints cannot fully separate β-lactamase-positive from β-lactamase-negative strains, and EUCAST recommends the zone edge test. Literature on nitrocefin-based testing and the zone edge test is scarce with wide variations in reported assay performance. Methods: This study compared two different nitrocefin-based commercial and in-house tests and the EUCAST-based zone edge test for penicillinase detection in S...
April 1, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28004151/reciprocal-regulation-of-mtor-complexes-in-pancreatic-islets-from-humans-with-type-2-diabetes
#15
Ting Yuan, Sahar Rafizadeh, Kanaka Durga Devi Gorrepati, Blaz Lupse, Jose Oberholzer, Kathrin Maedler, Amin Ardestani
AIMS/HYPOTHESIS: Mechanistic target of rapamycin complex 1 (mTORC1) is a master regulator of nutritional status at the cellular and organismic level. While mTORC1 mediates beta cell growth and expansion, its hyperactivation has been observed in pancreatic islets from animal models of type 2 diabetes and leads to beta cell loss. We sought to determine whether such mTORC1 activation occurs in humans with type 2 diabetes or in metabolically stressed human islets and whether mTORC1 blockade can restore beta cell function of diabetic islets...
December 21, 2016: Diabetologia
https://www.readbyqxmd.com/read/27992232/optically-detected-degradation-of-nayf4-yb-tm-based-upconversion-nanoparticles-in-phosphate-buffered-saline-solution
#16
Olivija Plohl, Marco Kraft, Janez Kovač, Blaž Belec, Maja Ponikvar-Svet, Christian Würth, Darja Lisjak, Ute Resch-Genger
In a proof-of-concept study, we assessed different analytical and spectroscopic parameters for stability screening of differently sized β-NaYF4:20 mol % Yb(3+), 2 mol % Tm(3+) upconversion nanoparticles (UCNPs) exemplarily in the bioanalytically relevant buffer phosphate buffered saline (PBS; pH 7.4) at 37 and 50 °C. This included the potentiometric determination of the amount of released fluoride ions, surface analysis with X-ray photoelectron spectroscopy (XPS), and steady-state and time-resolved fluorescence measurements...
January 3, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/27957840/all-solid-state-reference-electrode-with-heterogeneous-membrane
#17
Andrzej Lewenstam, Teresa Blaz, Jan Migdalski
Novel reference electrodes with a solid contact coated by a heterogeneous polymer membrane are described. The electrodes are obtained using Ag nanoparticles, AgBr, KBr suspended in tetrahydrofuran solution of PVC and DOS and deposited on Ag substrate, or another substrate covered with Ag, by drop casting. After a short period of soaking in a KBr solution, stable and reproducible formal potentials of -157 ± 2 mV (vs Ag/AgCl/3 M KCl) were observed, and the solid-contact reference electrodes were ready to use...
December 22, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27928206/doping-attitudes-and-covariates-of-potential-doping-behaviour-in-high-level-team-sport-athletes-gender-specific-analysis
#18
Damir Sekulic, Enver Tahiraj, Milan Zvan, Natasa Zenic, Ognjen Uljevic, Blaz Lesnik
Team sports are rarely studied with regard to doping behaviour and doping-related factors regardless of their global popularity. This study aimed to investigate doping factors and covariates of potential doping behaviour in high-level team-sport athletes. The subjects were 457 high-performing, national- and international-level athletes (21.9 ± 3.4 years of age; 179 females) involved in volleyball (n = 77), soccer (n = 163), basketball (n = 114) and handball (n = 103). Previously validated self-administered questionnaires aimed at evidencing sport factors, doping-related factors, knowledge on sport nutrition and doping, and attitudes to performance enhancement were used...
December 2016: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/27927926/clinical-and-microbiological-aspects-of-%C3%AE-lactam-resistance-in-staphylococcus-lugdunensis
#19
Ian H McHardy, Jennifer Veltman, Janet Hindler, Katia Bruxvoort, Marissa M Carvalho, Romney M Humphries
Antimicrobial susceptibility results from broth microdilution MIC testing of 993 Staphylococcus lugdunensis isolates recovered from patients at a tertiary care medical center from 2008 to 2015 were reviewed. Ninety-two oxacillin-susceptible isolates were selected to assess the accuracy of penicillin MIC testing, the penicillin disk diffusion test, and three β-lactamase tests, including the cefoxitin-induced nitrocefin test, penicillin cloverleaf assay, and penicillin disk zone edge test. The results of all phenotypic tests were compared to the results of blaZ PCR...
February 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27913076/biofilm-production-and-beta-lactamic-resistance-in-brazilian-staphylococcus-aureus-isolates-from-bovine-mastitis
#20
Viviane Figueira Marques, Cássia Couto da Motta, Bianca da Silva Soares, Dayanne Araújo de Melo, Shana de Mattos de Oliveira Coelho, Irene da Silva Coelho, Helene Santos Barbosa, Miliane Moreira Soares de Souza
Staphylococcus spp. play an important role in the etiology of bovine mastitis. Staphylococcus aureus is considered the most relevant species due to the production of virulence factors such as slime, which is required for biofilm formation. This study aimed to evaluate biofilm production and its possible relation to beta-lactamic resistance in 20 S. aureus isolates from bovine mastitic milk. The isolates were characterized by pheno-genotypic and MALDI TOF-MS assays and tested for genes such as icaA, icaD, bap, agr RNAIII, agr I, agr II, agr III, and agr IV, which are related to slime production and its regulation...
January 2017: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
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