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https://www.readbyqxmd.com/read/29894946/-1-h-nmr-metabolomics-of-microbial-metabolites-in-the-four-mw-agricultural-biogas-plant-reactors-a-case-study-of-inhibition-mirroring-the-acute-rumen-acidosis-symptoms
#1
Boštjan Murovec, Damjan Makuc, Sabina Kolbl Repinc, Zala Prevoršek, Domen Zavec, Robert Šket, Klemen Pečnik, Janez Plavec, Blaž Stres
In this study, nuclear magnetic resonance (1 H NMR) spectroscopic profiling was used to provide a more comprehensive view of microbial metabolites associated with poor reactor performance in a full-scale 4 MW mesophilic agricultural biogas plant under fully operational and also under inhibited conditions. Multivariate analyses were used to assess the significance of differences between reactors whereas artificial neural networks (ANN) were used to identify the key metabolites responsible for inhibition and their network of interaction...
June 9, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29891607/the-prevalence-of-a-cefazolin-inoculum-effect-associated-with-blaz-gene-types-among-methicillin-susceptible-staphylococcus-aureus-isolates-from-four-major-medical-centers-in-chicago
#2
Sheila K Wang, Annette Gilchrist, Anastasia Loukitcheva, Balbina J Plotkin, Ira M Sigar, Alan E Gross, John N O'Donnell, Natasha Pettit, Amy Buros, Tristan O'Driscoll, Nathaniel J Rhodes, Cindy Bethel, John Segreti, Angella Charnot-Katsikas, Kamaljit Singh, Marc H Scheetz
Cefazolin efficacy with high inoculum methicillin-susceptible Staphylococcus aureus (MSSA) infections remains in question due to therapeutic failure inferred from an inoculum effect. This study investigated the local prevalence of a cefazolin inoculum effect (CInE) and its association with staphylococcal blaZ gene types among MSSA isolates in the Chicago area. Four medical centers in Chicago, Illinois contributed MSSA isolates. Cefazolin MICs (C-MIC) were determined at 24 hours by broth microdilution method using standard inocula (SI, 5 x 105 CFU/mL) and high inocula (HI, 5 x 107 CFU/mL)...
June 11, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29754001/spatial-and-temporal-variability-of-personal-environmental-exposure-to-radio-frequency-electromagnetic-fields-in-children-in-europe
#3
Laura Ellen Birks, Benjamin Struchen, Marloes Eeftens, Luuk van Wel, Anke Huss, Peter Gajšek, Leeka Kheifets, Mara Gallastegi, Albert Dalmau-Bueno, Marisa Estarlich, Mariana F Fernandez, Inger Kristine Meder, Amparo Ferrero, Ana Jiménez-Zabala, Maties Torrent, Tanja G M Vrijkotte, Elisabeth Cardis, Jørn Olsen, Blaž Valič, Roel Vermeulen, Martine Vrijheid, Martin Röösli, Mònica Guxens
BACKGROUND: Exposure to radiofrequency electromagnetic fields (RF-EMF) has rapidly increased and little is known about exposure levels in children. This study describes personal RF-EMF environmental exposure levels from handheld devices and fixed site transmitters in European children, the determinants of this, and the day-to-day and year-to-year repeatability of these exposure levels. METHODS: Personal environmental RF-EMF exposure (μW/m2 , power flux density) was measured in 529 children (ages 8-18 years) in Denmark, the Netherlands, Slovenia, Switzerland, and Spain using personal portable exposure meters for a period of up to three days between 2014 and 2016, and repeated in a subsample of 28 children one year later...
May 10, 2018: Environment International
https://www.readbyqxmd.com/read/29739703/hippo-signaling-key-emerging-pathway-in-cellular-and-whole-body-metabolism
#4
REVIEW
Amin Ardestani, Blaz Lupse, Kathrin Maedler
The evolutionarily conserved Hippo pathway is a key regulator of organ size and tissue homeostasis. Its dysregulation is linked to multiple pathological disorders. In addition to regulating development and growth, recent studies show that Hippo pathway components such as MST1/2 and LATS1/2 kinases, as well as YAP/TAZ transcriptional coactivators, are regulated by metabolic pathways and that the Hippo pathway controls metabolic processes at the cellular and organismal levels in physiological and metabolic disease states such as obesity, type 2 diabetes (T2D), nonalcoholic fatty liver disease (NAFLD), cardiovascular disorders, and cancer...
May 5, 2018: Trends in Endocrinology and Metabolism: TEM
https://www.readbyqxmd.com/read/29737548/prevotella-strains-and-lactamic-resistance-gene-distribution-in-different-oral-environments-of-children-with-pulp-necrosis
#5
B Roese de Lima, G F Nicoloso, C C Fatturi-Parolo, M B C Ferreira, F Montagner, L Casagrande
AIM: To determine the presence of Prevotella species, the cfxA/cfxA2, blaZ and blaTEM genes associated with resistance to lactamic agents in different oral niches of children with pulp necrosis. METHODOLOGY: Children with pulp necrosis in primary teeth had samples of saliva, supragingival, pulp chamber and root canal biofilms collected and tested for Prevotella species (P. intermedia, P nigrescens, P. tannerae) and for beta-lactam resistance genes (cfxA / cfxA2, blaZ and blaTEM)...
May 8, 2018: International Endodontic Journal
https://www.readbyqxmd.com/read/29729922/antimicrobial-resistance-in-non-aureus-staphylococci-isolated-from-milk-is-associated-with-systemic-but-not-intramammary-administration-of-antimicrobials-in-dairy-cattle
#6
Diego B Nobrega, Jeroen De Buck, Herman W Barkema
Non-aureus staphylococci (NAS) are the bacteria most frequently isolated from bovine milk. Objectives of this study were to determine herd-level associations between antimicrobial use (AMU) and prevalence of antimicrobial resistance (AMR) and antimicrobial resistance genes in NAS according to antimicrobials and routes of administration. The AMR profile was determined using a micro-broth dilution method against a panel of 23 antimicrobials for 1,702 NAS isolates obtained from 89 herds. A subset of these isolates (n = 405) was submitted to whole-genome sequencing, and the presence of AMR genes was determined using data from 4 databases...
May 2, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29716961/whole-genome-sequence-and-comparative-genomics-analysis-of-multi-drug-resistant-environmental-staphylococcus-epidermidis-st59
#7
Zhen Xu, Raju Misra, Dorota Jamrozy, Gavin K Paterson, Ronald R Cutler, Mark A Holmes, Saheer Gharbia, Hermine V Mkrtchyan
Staphylococcus epidermidis is a major opportunistic pathogen primarily recovered from device-associated healthcare associated infections (DA-HAIs). Although S. epidermidis and other coagulase-negative staphylococci (CoNS) are less virulent than Staphylococcus aureus , these bacteria are an important reservoir of antimicrobial resistance genes and resistance-associated mobile genetic elements that can be transferred between staphylococcal species. We report a whole genome sequence of a multidrug resistant S...
April 30, 2018: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29708829/the-impact-of-testosterone-replacement-therapy-on-glycemic-control-vascular-function-and-components-of-the-metabolic-syndrome-in-obese-hypogonadal-men-with-type-2-diabetes
#8
Kristina Groti, Ivan Žuran, Blaž Antonič, Lidija Foršnarič, Marija Pfeifer
OBJECTIVE: This study set out to assess effects of testosterone replacement therapy (TRT) on parameters of metabolic syndrome and vascular function in obese hypogonadal males with type 2 diabetes mellitus (DM2). STUDY DESIGN: Fifty-five obese hypogonadal diabetic males on oral hypoglycemic treatment were enrolled into this one-year, double-blind, randomized, placebo-controlled clinical study. Group T (n = 28) was treated with testosterone undecanoate (1000 mg i...
April 30, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/29698470/hiv-1-transmitted-drug-resistance-in-slovenia-and-its-impact-on-predicted-treatment-effectiveness-2011-2016-update
#9
Maja M Lunar, Snježana Židovec Lepej, Janez Tomažič, Tomaž D Vovko, Blaž Pečavar, Gabriele Turel, Manja Maver, Mario Poljak
HIV-positive individuals that have a detected transmitted drug resistance (TDR) at baseline have a higher risk of virological failure with antiretroviral therapy (ART). This study offers an update on the prevalence of TDR in Slovenia, looks for onward transmission of TDR, and reassesses the need for baseline drug resistance testing. Blinded questionnaires and partial pol sequences were obtained from 54.5% (168/308) of all of the patients diagnosed with HIV-1 from 2011 to 2016. Subtype B was detected in 82.7% (139/168) of patients, followed by subtype A (8...
2018: PloS One
https://www.readbyqxmd.com/read/29688964/comparison-of-three-surgical-treatment-options-for-unicameral-bone-cysts-in-humerus
#10
Blaž Mavčič, Vinay Saraph, Magdalena M Gilg, Marko Bergovec, Janez Brecelj, Andreas Leithner
Treatment of unicameral bone cysts (UBC) in the humerus with drainage screws is scarcely reported in the literature. The aim of this retrospective study was to compare drainage screws and alternative treatment methods with respect to the number of required surgical procedures to achieve sufficient UBC healing, postoperative fractures/recurrences/complications, and radiological outcome. Medical archives of two tertiary orthopedic referral centers were screened for all patients who were treated surgically for humeral UBC in the period 1991-2015 with a histologically/cytologically confirmed diagnosis...
April 23, 2018: Journal of Pediatric Orthopedics. Part B
https://www.readbyqxmd.com/read/29685228/phenotypic-and-genotypic-characteristics-of-staphylococcus-aureus-isolates-from-zoo-and-wild-animals
#11
Andrea T Feßler, Patricia Thomas, Kristin Mühldorfer, Mirjam Grobbel, Julian Brombach, Inga Eichhorn, Stefan Monecke, Ralf Ehricht, Stefan Schwarz
Antimicrobial resistance of Staphylococcus aureus is a major problem in human and veterinary medicine. The aim of this study was to characterise S. aureus isolates from wild and zoo animals mainly associated with bacterial infections. In total, 23 S. aureus isolates, including nine from wild animals and 14 from zoo animals, were obtained during routine diagnostics. All isolates were subjected to multilocus sequence typing (MLST), spa typing, macrorestriction analysis with subsequent SmaI pulsed-field gelelectrophoresis (PFGE), antimicrobial susceptibility testing and S...
May 2018: Veterinary Microbiology
https://www.readbyqxmd.com/read/29683776/coagulase-negative-staphylococci-isolated-from-human-bloodstream-infections-showed-multidrug-resistance-profile
#12
Silvia H S P Pedroso, Savio H C Sandes, Robledo A T Filho, Alvaro C Nunes, Jose C Serufo, Luiz M Farias, Maria A R Carvalho, Maria R Q Bomfim, Simone G Santos
Coagulase-negative staphylococci (CNS) are important pathogens causing nosocomial infections worldwide with increasing resistance to antimicrobials. The aim of this study was to characterize resistance aspects of CNS isolated from patients with bloodstream infections acquired in hospitals in Belo Horizonte, MG, Brazil. Staphylococcus strains were characterized using repetitive sequence-based polymerase chain reaction (rep-PCR) fingerprinting with (GTG)5 primer. Phenotypic resistance was analyzed using AST-P5085 card (bioMérieuxVitek® )...
June 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29670510/differential-expression-of-several-mirnas-and-the-host-genes-aatk-and-dnm2-in-leukocytes-of-sporadic-als-patients
#13
Katarina Vrabec, Emanuela Boštjančič, Blaž Koritnik, Lea Leonardis, Leja Dolenc Grošelj, Janez Zidar, Boris Rogelj, Damjan Glavač, Metka Ravnik-Glavač
Genetic studies have managed to explain many cases of familial amyotrophic lateral sclerosis (ALS) through mutations in several genes. However, the cause of a majority of sporadic cases remains unknown. Recently, epigenetics, especially miRNA studies, show some promising aspects. We aimed to evaluate the differential expression of 10 miRNAs, including miR-9, miR-338, miR-638, miR-663a, miR-124a, miR-143, miR-451a, miR-132, miR-206, and let-7b, for which some connection to ALS was shown previously in ALS culture cells, animal models or patients, and in three miRNA host genes, including C1orf61 (miR-9), AATK (miR-338), and DNM2 (miR-638), in leukocyte samples of 84 patients with sporadic ALS...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29668933/the-human-clone-st22-sccmec-iv-methicillin-resistant-staphylococcus-aureus-isolated-from-swine-herds-and-wild-primates-in-nepal-is-man-the-common-source
#14
Marilyn C Roberts, Prabhu Raj Joshi, Alexander L Greninger, Daira Melendez, Saroj Paudel, Mahesh Acharya, Nabin Kishor Bimali, Narayan P Koju, David No, Mukesh Chalise, Randall C Kyes
Swine nasal samples [n = 282] were collected from 12 randomly selected farms around Kathmandu, Nepal, from healthy animals. In addition, wild monkey (Macaca mulatta) saliva samples [n = 59] were collected near temples areas in Kathmandu using a non-invasive sampling technique. All samples were processed for MRSA using standardized selective media and conventional biochemical tests. MRSA verification was done and isolates characterized by SCCmec, multilocus sequence typing, whole genome sequencing [WGS] and antibiotic susceptibilities...
May 1, 2018: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/29652621/dose-modifying-factor-of-radiation-therapy-with-concurrent-cisplatin-treatment-in-hpv-positive-squamous-cell-carcinoma-a-preclinical-study
#15
Ajda Prevc, Simona Kranjc, Maja Cemazar, Vesna Todorovic, Bojana Zegura, Matjaz Novak, Metka Filipic, Margareta Strojan Flezar, Irena Srebotnik Kirbis, Ana Rotter, Andreja Brozic, Martina Niksic Zakelj, Mario Poljak, Lea Hosnjak, Blaz Groselj, Primoz Strojan, Gregor Sersa
Human papillomavirus (HPV) is an important etiological factor in oropharyngeal squamous cell carcinoma (SCC). Compared to HPV-negative tumors, HPV-positive oropharyngeal SCC has shown a better response to nonsurgical treatments. In this study, we determined the dose-modifying factors for HPV-positive tumors with single-dose irradiation, with or without low radiosensitizing doses of cisplatin. In vitro, we determined an increased radiosensitivity of HPV-positive SCC, which might be a consequence of HPV-induced changes in the cell cycle regulation and DNA damage response, leading to increased cell death...
June 2018: Radiation Research
https://www.readbyqxmd.com/read/29618798/differential-expression-of-micrornas-and-other-small-rnas-in-muscle-tissue-of-patients-with-als-and-healthy-age-matched-controls
#16
Anja Kovanda, Lea Leonardis, Janez Zidar, Blaž Koritnik, Leja Dolenc-Groselj, Stanislava Ristic Kovacic, Tomaž Curk, Boris Rogelj
Amyotrophic lateral sclerosis is a late-onset disorder primarily affecting motor neurons and leading to progressive and lethal skeletal muscle atrophy. Small RNAs, including microRNAs (miRNAs), can serve as important regulators of gene expression and can act both globally and in a tissue-/cell-type-specific manner. In muscle, miRNAs called myomiRs govern important processes and are deregulated in various disorders. Several myomiRs have shown promise for therapeutic use in cellular and animal models of ALS; however, the exact miRNA species differentially expressed in muscle tissue of ALS patients remain unknown...
April 4, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29593560/intestinal-metagenomes-and-metabolomes-in-healthy-young-males-inactivity-and-hypoxia-generated-negative-physiological-symptoms-precede-microbial-dysbiosis
#17
Robert Šket, Tadej Debevec, Susanne Kublik, Michael Schloter, Anne Schoeller, Boštjan Murovec, Katarina Vogel Mikuš, Damjan Makuc, Klemen Pečnik, Janez Plavec, Igor B Mekjavić, Ola Eiken, Zala Prevoršek, Blaž Stres
We explored the metagenomic, metabolomic and trace metal makeup of intestinal microbiota and environment in healthy male participants during the run-in (5 day) and the following three 21-day interventions: normoxic bedrest (NBR), hypoxic bedrest (HBR) and hypoxic ambulation (HAmb) which were carried out within a controlled laboratory environment (circadian rhythm, fluid and dietary intakes, microbial bioburden, oxygen level, exercise). The fraction of inspired O2 (Fi O2 ) and partial pressure of inspired O2 (Pi O2 ) were 0...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29587369/an-scf-fbxo28-e3-ligase-protects-pancreatic-%C3%AE-cells-from-apoptosis
#18
Kanaka Durga Devi Gorrepati, Wei He, Blaz Lupse, Ting Yuan, Kathrin Maedler, Amin Ardestani
Loss of pancreatic β-cell function and/or mass is a central hallmark of all forms of diabetes but its molecular basis is incompletely understood. β-cell apoptosis contributes to the reduced β-cell mass in diabetes. Therefore, the identification of important signaling molecules that promote β-cell survival in diabetes could lead to a promising therapeutic intervention to block β-cell decline during development and progression of diabetes. In the present study, we identified F-box protein 28 (FBXO28), a substrate-recruiting component of the Skp1-Cul1-F-box (SCF) ligase complex, as a regulator of pancreatic β-cell survival...
March 24, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29524153/small-mammals-as-sentinels-of-antimicrobial-resistant-staphylococci
#19
Vladimír Kmeť, Anna Čuvalová, Michal Stanko
A total of 39 coagulase-negative staphylococci and seven Staphylococcus aureus strains were isolated from small mammal feces, i.e., the striped field mouse (Apodemus agrarius) and the yellow-necked mouse (A. flavicollis) in two sampling areas, deciduous forest and karst plains. MALDI-TOF analysis revealed five species of coagulase-negative staphylococci: S. sciuri, S. hominis, S. warneri, S. haemolyticus, and S. xylosus. All strains were susceptible to tetracycline, linezolid, vancomycin, and teicoplanin. Three MRSA strains with the mecA gene were detected...
March 9, 2018: Folia Microbiologica
https://www.readbyqxmd.com/read/29522957/protein-a-affinity-chromatography-of-chinese-hamster-ovary-cho-cell-culture-broths-containing-biopharmaceutical-monoclonal-antibody-mab-experiments-and-mechanistic-transport-binding-and-equilibrium-modeling
#20
Matic Grom, Mirijam Kozorog, Simon Caserman, Andrej Pohar, Blaž Likozar
Protein A-based affinity chromatography is a highly-efficient separation method to capture, purify and isolate biosimilar monoclonal antibodies (mAb) - an important medical product of biopharmaceutical industrial manufacturing. It is considered the most expensive step in purification downstream operations; therefore, its performance optimization offers a great cost saving in the overall production expenditure. The biochemical mixture-separating specific interaction experiments with Chinese hamster ovary (CHO) cell culture harvest, containing glycosylated extracellular immunoglobulins (Ig), were made using five different state-of-the-art commercial resins...
April 15, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
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