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Lichen sclerosus

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https://www.readbyqxmd.com/read/28801716/-plastic-surgery-reconstruction-of-the-adult-buried-penis-option-or-obligation
#1
REVIEW
S Mühlstädt, P Anheuser, N Mohammed, A D Bach
The adult buried penis afflicts the patient with shame and is also potentially associated with considerable urogenital complications. Due to obesity, chronic urogenital lymphedema or subsequent inflammatory urogenital conditions, such as a lichen sclerosus et atrophicus, the clinical appearance of the adult buried penis is extremely variable. Epidemiological data are non-existent. Therapeutically, a combination of various plastic surgery procedures is often necessary for the best esthetic and functional results...
August 11, 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/28796915/clearance-in-vulvar-lichen-sclerosus-a-realistic-treatment-endpoint-or-a-chimera
#2
A Borghi, A Virgili, S Minghetti, G Toni, M Corazza
BACKGROUND: according to the current guidelines, the aim of vulvar lichen sclerosus (VLS) treatment is to improve symptoms and signs, not to cure. OBJECTIVE: to assess i) the rate of VLS patients who achieved complete clearance of symptoms or objective features, or both, with a 12-week pharmacological treatment and ii) the predictive value of therapeutic response of the demographic and clinical features. METHODS: we retrospectively included VLS patients who had undergone any topical treatment for 12 weeks; demographics, history, VLS-related symptoms and objective features recorded at baseline and on completion of treatment were collected and elaborated...
August 10, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28795241/papillomavirus-genotyping-on-formaldehyde-fixed-paraffin-embedded-tissues-in-vulvar-intraepithelial-neoplasia
#3
S Mazellier, B Dadone-Montaudie, A Chevallier, C Loubatier, S Vitale, N Cardot-Leccia, K Angeli, C Trastour, J Delotte, V Giordanengo, D Ambrosetti
PURPOSE: Few studies have described the epidemiology of human papillomavirus (HPV) in vulvar intraepithelial neoplasia (VIN). The aim of this study was to genotype HPV on formalin fixed paraffin-embedded tissues in VIN lesions. METHODS: A 5-year retrospective study was conducted by including all patients attending the teaching hospital of Nice with a diagnosis of VIN between 1st January 2010 and 31st December 2014. For all patients, HPV genotyping was performed with the PapilloCheck(®) microarray kit, routinely used on cervical cytology samples, and optimized for formaldehyde fixed paraffin-embedded tissues in VIN...
August 9, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28793884/therapeutic-comparison-between-treatments-for-vulvar-lichen-sclerosus-study-protocol-of-a-randomized-prospective-and-controlled-trial
#4
Renata A Belotto, Maria Cristina Chavantes, João Paulo Tardivo, Roberto Euzébio Dos Santos, Raquel Civolani Marques Fernandes, Anna Carolina Ratto Tempestini Horliana, Christiane Pavani, Daniela Fátima Teixeira da Silva
BACKGROUND: Vulvar lichen sclerosus (VLS) is a lymphocyte-mediated disease of unknown etiology that can cause intense itching as well stenosis, hindering the evacuation and urination. It can also limit the sex life due to severe local pruritus, pain and dyspareunia (pain during sexual intercourse). The standard treatment for this disease is the use of topical corticosteroids to reduce the clinical symptoms and to try to increase disease-free intervals. Photodynamic therapy (PDT), a treatment that associates a light radiation with a photosensitizing agent and photobiomodulation (PBM) are therapies that can promote effective immunomodulatory responses at the application site by means of photophysical and photochemical phenomena from the molecular to the systemic level, which promote their use in chronic dermatoses...
August 10, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/28779991/surgical-management-of-adult-acquired-buried-penis-escutcheonectomy-scrotectomy-and-penile-split-thickness-skin-graft
#5
Thomas W Fuller, Katherine Theisen, Paul Rusilko
OBJECTIVE: To demonstrate the surgical management of adult acquired buried penis (AABP). Affected patients have poor sexual function, urinary dribbling with subsequent skin breakdown, mood disturbance, lichen sclerosus with subsequent urethral stricture, and poor quality of life. Previous efforts have described limited repairs including an isolated resection of the escutcheon, which unfortunately often leads to reburying. We present a more extensive surgical repair including escutcheonectomy, scrotoplasty, and penile split-thickness skin graft (STSG) to provide a durable definitive repair...
July 6, 2017: Urology
https://www.readbyqxmd.com/read/28764581/skin-diseases-of-the-vulva-inflammatory-erosive-ulcerating-and-apocrine-gland-diseases-zinc-and-vitamin-deficiency-vulvodynia-and-vestibulodynia
#6
Freja Lærke Sand, Simon Francis Thomsen
Chronic, inflammatory and ulcerating mucocutaneous diseases that can affect the vulvar area are reviewed: lichen sclerosus, lichen planus, plasma cell vulvitis, complex aphthosis, Behcet's disease, pyoderma gangrenosum, metastatic Crohn's disease, dyskeratotic skin diseases (Hailey-Hailey disease and Darier's disease), autoimmune bullous diseases (mucous membrane pemphigoid and pemphigus vulgaris) and hidradenitis suppurativa. Also, vulvodynia and vestibulodynia, zinc and vitamin B deficiency are described.
August 1, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28753858/correlation-between-primary-hypospadias-repair-and-subsequent-urethral-strictures-in-a-series-of-408-adult-patients
#7
Guido Barbagli, Nicola Fossati, Alessandro Larcher, Francesco Montorsi, Salvatore Sansalone, Denis Butnaru, Massimo Lazzeri
BACKGROUND: The correlation between primary hypospadias repair and subsequent urethral strictures in adults has never been addressed. OBJECTIVE: To evaluate the correlation between the site of primary hypospadias repair and the site of subsequent strictures and to investigate the predictive factors of failure after urethroplasty. DESIGN, SETTING, AND PARTICIPANTS: An observational, retrospective, descriptive study of adult patients with urethral strictures following hypospadias surgery was carried out in a single centre...
February 21, 2017: European Urology Focus
https://www.readbyqxmd.com/read/28753097/mometasone-furoate-in-the-treatment-of-vulvar-lichen-sclerosus-could-its-formulation-influence-efficacy-tolerability-and-adherence-to-treatment
#8
Monica Corazza, Annarosa Virgili, Giulia Toni, Alessandro Borghi
Purpose To assess the effectiveness, tolerability and convenience of the cream formulation of mometasone furoate 0.1% (MMF) in the treatment of active vulvar lichen sclerosus (VLS) and to compare the cream with the ointment formulation. Methods The following efficacy parameters were assessed in 27 VLS patients treated with MMF cream for 12 weeks (group A): i) response rate, ii) percentage of patients achieving an improvement from baseline of ≥75% in subjective and objective scores, iii) mean reduction in subjective and objective scores...
July 28, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28750140/the-diagnosis-and-management-of-male-genital-lichen-sclerosus-a-retrospective-review-of-301-patients
#9
G Kravvas, T N Shim, P R Doiron, A Freeman, C Jameson, S Minhas, A Muneer, C B Bunker
INTRODUCTION: Male genital lichen sclerosus (MGLSc) is an acquired, chronic, inflammatory skin disease that is associated with significant morbidity and squamous cell carcinoma of the penis (PSCC). However, some clinical, diagnostic and management controversies endure, including the relationship with penile intraepithelial neoplasia (PeIN). OBJECTIVES: To clarify clinical presentations, diagnostic approaches, histological findings, response to treatment and the relationship with PeIN...
July 27, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28738760/substitution-urethroplasty-for-anterior-urethral-stricture-repair-comparison-between-lingual-mucosa-graft-and-pedicled-skin-flap
#10
Qiang Fu, Yumeng Zhang, Jiong Zhang, Hong Xie, Ying-Long Sa, Sanbao Jin
OBJECTIVES: The aim of this study was to compare the effectiveness and outcomes of lingual mucosa graft (LMG) urethroplasty versus pedicled skin flap (PSF) urethroplasty in the repair of anterior urethral strictures. MATERIALS AND METHODS: A retrospective study in one urological center examined 293 male patients with anterior urethral strictures who received substitution urethroplasty from 2006 to 2015. Of these, 199 patients received PSF urethroplasty and 94 received LMG urethroplasty...
July 25, 2017: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/28737238/the-possible-role-of-human-papillomavirus-infection-in-the-development-of-lichen-sclerosus
#11
REVIEW
Anna K Hald, Jan Blaakaer
Lichen sclerosus (LS) is a chronic inflammatory skin disease of unknown origin predominantly affecting the anogenital area that causes pruritus and pain and is associated with an increased risk of malignancy. In some cases, LS vanishes after application of imiquimod, raising the question whether human papillomavirus (HPV) may have an etiopathogenic role in anogenital LS. The databases MEDLINE and Embase were systematically searched using the PRISMA guidelines. Twenty-seven papers were included that reported the prevalence of HPV in LS and in LS associated with neoplasia...
July 24, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28706405/vulvar-lichen-sclerosus-et-atrophicus
#12
REVIEW
Pragya Ashok Nair
Vulvar lichen sclerosus (VLS) is a chronic inflammatory dermatosis characterized by ivory-white plaques or patches with glistening surface commonly affecting the vulva and anus. Common symptoms are irritation, soreness, dyspareunia, dysuria, and urinary or fecal incontinence. Anogenital lichen sclerosus (LS) is characterized by porcelain-white atrophic plaques, which may become confluent extending around the vulval and perianal skin in a figure of eight configuration. Thinning and shrinkage of the genital area make coitus, urination, and defecation painful...
April 2017: Journal of Mid-life Health
https://www.readbyqxmd.com/read/28701998/thyroid-autoimmunity-and-lichen
#13
REVIEW
Fabrizio Guarneri, Roberta Giuffrida, Flavia Di Bari, Serafinella Patrizia Cannavò, Salvatore Benvenga
Lichen planus (LP) and lichen sclerosus (LS) are cutaneous-mucous diseases with uncertain epidemiology. Current data, which are likely to be underestimated, suggest a prevalence in the general population of 0.1-4% for cutaneous LP, 1.27-2.0% for oral LP, and 0.1-3.3% for LS. While etiology of lichen is still unknown, clinical and histological evidence show an (auto)immune pathogenesis. Association of lichen with autoimmune thyroid disease (AITD) has been investigated in few studies. This association appears better defined in the case of LS, while is more controversial for LP...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28661705/lichen-sclerosus-in-women-a-review
#14
F R Pérez-López, P Vieira-Baptista
Female lichen sclerosus is a chronic inflammatory dermatitis, with a predilection for the anogenital area, which in some cases can become seriously distorted (atrophy of the labia minora, phimosis, introital stenosis, etc.). Most cases are diagnosed in postmenopausal women, but it can affect women of any age. Lichen sclerosus is usually a pruriginous condition, although it can also be asymptomatic. It is associated with an increased risk of vulvar cancer, even though it is not a premalignant condition itself...
August 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28633746/extragenital-bullous-lichen-sclerosus-on-the-anterior-lower-extremities-report-of-a-case-and-literature-review
#15
Nichelle Arnold, Mitch Manway, Sean Stephenson, Howard Lipkin
Lichen sclerosus (LS) is a benign, chronic, inflammatory skin disease with a predilection for the anogenital region in women. Although males can also be affected, the ratio of female to male incidence has been reported to be as high as 6-10:1 and possesses a bimodal age distribution of pre-pubertal girls and postmenopausal women [1, 2]. Affected skin usually demonstrates polygonal papules that coalesce into porcelain white plaques and can be associated with edema, telangiectasias, and comedo-like plug formation [3]...
June 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28633743/lichen-sclerosus-et-atrophicus-atypical-case-simulating-lichen-planus
#16
Rafaella C Olinger, Joseph L Jorizzo, Felipe B Cerci
Lichen sclerosus et atrophicus (LSA) is a chronic inflammatory dermatosis, characterized by shiny, atrophic, hypochromic papules with a predilection for the genital and perineal skin. Extragenital involvement may occur, but is rare in the isolated form. LSA more commonly affects prepubertal and postmenopausal women. We describe an unusual case of isolated extragenital LSA, restricted to the wrists and mimicking lichen planus.
June 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28600871/substitution-urethroplasty-using-oral-mucosa-graft-for-male-anterior-urethral-stricture-disease-current-topics-and-reviews
#17
REVIEW
Akio Horiguchi
Male anterior urethral stricture is scarring of the subepithelial tissue of the corpus spongiosum that constricts the urethral lumen, decreasing the urinary stream. Its surgical management is a challenging problem, and has changed dramatically in the past several decades. Open surgical repair using grafts or flaps, called substitution urethroplasty, has become the gold standard procedure for anterior urethral strictures that are not amenable to excision and primary anastomosis. Oral mucosa harvested from the inner cheek (buccal mucosa) is an ideal material, and is most commonly used for substitution urethroplasty, and lingual mucosa harvested from the underside of the tongue has recently emerged as an alternative material with equivalent outcome...
June 10, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/28597554/clinical-outcomes-in-a-specialist-male-genital-skin-clinic-prospective-follow-up-of-600-patients
#18
M Shah
It is important to assess outcomes for medical interventions in order to focus scarce resources on outcomes with a known positive benefit. An open, observational study was performed to assess the clinical outcomes of 600 male patients with a genital skin problem attending a specialist secondary care dermatology facility. Patients were mainly referred by general practitioners and genitourinary medicine physicians. Outcome was measured at 3 and 6 months, and was determined by clinical examination and assessment of patient symptoms...
June 8, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28593367/vulvar-lichen-sclerosus-in-women-is-associated-with-lower-urinary-tract-symptoms
#19
Corina Christmann-Schmid, Melanie Hediger, Sabine Gröger, Jörg Krebs, Andreas R Günthert
INTRODUCTION AND HYPOTHESIS: Lichen sclerosus (LS) is thought to be primarily a disease of postmenopausal women. Little is reported about lower urinary tract symptoms (LUTS) in association with LS. The aims of this study were to evaluate the odds of having LS-associated LUTS and to identify the predominant type of LS-associated bladder dysfunction. METHODS: This was a cross-sectional study with two cohorts investigating the association between LS and LUTS and the predominant type of LS-associated bladder dysfunction...
June 7, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28578370/uncommon-oral-manifestation-of-lichen-sclerosus-critical-analysis-of-cases-reported-from-1957-to-2016
#20
S Tomo, I-S Santos, S-A de Queiroz, D-G Bernabé, L-E Simonato, G-I Miyahara
BACKGROUND: Lichen sclerosus is a mucocutaneous autoimmune disease which might be initiated by infectious pathogens as Borrelia Bugrdorferi and HPV. This disease shows destructive potential and is rarely diagnosed in oral mucosa. The purpose of this paper is to evaluate the characteristics of cases described in literature from 1957 to 2016, looking to provide valuable evidence about clinicopathologic features of this disease. MATERIAL AND METHODS: A MedLine search was performed aiming to find oral lichen sclerosus cases in literature and discuss its demographical and pathological characteristics as well as treatment methods performed for these cases...
July 1, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
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