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Lichen sclerosus

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https://www.readbyqxmd.com/read/29785390/platelet-rich-plasma-prp-for-the-treatment-of-vulvar-lichen-sclerosus-in-a-premenopausal-woman-a-case-report
#1
D Franic, Z Iternička, M Franić-Ivanišević
The use of platelet-rich plasma (PRP) for the treatment of lichen sclerosus (LS) in a 38-year-old premenopausal woman is reported. The diagnosis was confirmed histologically and the symptoms documented using the ICIQ Vaginal Symptoms Questionnaire (ICIQ-VS) and the Female Sexual Function Index (FSFI) questionnaire. PRP was prepared from autologous blood using the Regen Cellular Matrix Kit. PRP was administered twice over two months. Histology at follow-up one month after the second administration showed the epidermis was nearly normal and upper dermal cellularity had been restored...
April 2018: Case Reports in Women's Health
https://www.readbyqxmd.com/read/29761782/-vulvar-intraepithelial-neoplasia
#2
Signe Østergård, Christina Steen Vorbeck, Mette Meinert
Vulvar intraepithelial neoplasia (VIN) is a rare but premalig-nant condition. VIN has two aetiological pathways: a human papillomavirus (HPV)-dependent pathway, which is a vulvar high-grade squamous intraepithelial lesion (HSIL), and an HPV-independent pathway, called differentiated VIN (d-VIN), associated with lichen sclerosus. d-VIN is more aggressive than vulvar HSIL. In case of symptoms, a biopsy should be performed. The recurrence risk is high: 25-50% regardless of treatment type. We recommend treatment with imiquimod as first choice to avoid mutilating surgery...
May 14, 2018: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29760622/skin-and-mucous-membranes-manifestations-of-dermatological-diseases-within-the-genital-area-in-females
#3
Katarzyna Plagens-Rotman, Renata Przybylska, Zygmunt Adamski, Magdalena Czarnecka-Operacz
Introduction: Lichen sclerosus et atrophicus (LSA) and an inversed type of psoriasis belong to a group of benign dermatoses usually located within the region of female external genitalia. The most common subjective symptoms reported by patients are itching, pain and changes in the color and structure of the skin. Aim: This paper presents 3 cases of patients suffering from selected dermatoses located within the external female genitalia treated at the Department of Dermatology, Poznan University of Medical Sciences...
April 2018: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/29729359/genital-lichen-sclerosus-et-atrophicus-a-benign-skin-disorder-with-malignant-aftermath
#4
Ankur Guliani, Sheetanshu Kumar, Divya Aggarwal, Muthu Sendhil Kumaran
Genital lichen sclerosus et atrophicus is an uncommon genital dermatosis. Its resemblance to vitiligo especially during the earlier stages leads to delay in its diagnosis. Apart from the common complications such as meatal stenosis, balanoposthitis, phimosis and painful erections, squamous cell carcinoma (SCC) is a rare but ominous complication of genital LSA. Herein, we present a case of long standing penile LSA complicated by SCC stressing upon the requirement of early diagnosis and management of LSA.
May 2, 2018: Urology
https://www.readbyqxmd.com/read/29707184/lichen-sclerosus-of-the-upper-lip-report-of-a-case-utilizing-shikata-s-modified-orcein-stain-and-review-of-the-literature
#5
Nikolaos Katsoulas, Georgios Prodromidis, Nikolaos G Nikitakis
Objectives: Lichen sclerosus is a rare chronic inflammatory disorder, affecting mainly the skin and the anogenital mucosa, while oral lesions can be the primary or the only manifestation of the disease. A rare case of oral lichen sclerosus, assessed histopathologically and histochemically, is presented, along with a thorough review of the English language literature. Material and Methods: A 32-year-old female presented an asymptomatic white patch affecting the skin and the mucosa of the upper lip, without other mucocutaneous involvement...
January 2018: Journal of Oral & Maxillofacial Research
https://www.readbyqxmd.com/read/29705404/oral-lichen-sclerosus-an-overview-and-report-of-three-cases
#6
REVIEW
J Robledo-Sierra, K Bäckman, J Öhman, M Jontell
Lichen sclerosus is an unusual, chronically relapsing mucocutaneous disease that usually afflicts the anogenital region. Oral lesions of lichen sclerosus are rare, with only 36 histologically verified cases reported to date. The classic histopathologic findings of oral lichen sclerosus include: an area of subepithelial hyalinization, loss of elastic fibres, and band-like mononuclear inflammatory infiltrate. Despite its rarity, oral lichen sclerosus should be included in the differential diagnosis of porcelain- or ivory-white macules...
April 25, 2018: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29681271/transitioning-patients-with-hypospadias-and-other-penile-abnormalities-to-adulthood-what-to-expect
#7
REVIEW
Keith Rourke, Luis H Braga
Hypospadias patients presenting to adult urologists do so with a wide range of symptoms and problems, including urethral stricture (45-72%), lower urinary tract symptoms (with or without stricture) (50-82%), urethrocutaneous fistula (16-30%), persisting hypospadias (14-43%), micturition spraying (24%), ventral curvature (14-24%), urinary tract infection (15-25%), or lichen sclerosus (13%; range 8-43). Many of these men have concurrent complications as the result of multiple operations and a variety of techniques...
April 2018: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29668094/updates-in-lichen-sclerosis-british-association-of-dermatologists-guidelines-for-the-management-of-lichen-sclerosus-2018
#8
EDITORIAL
R Akel, C Fuller
No abstract text is available yet for this article.
April 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29658796/lichen-sclerosus-of-the-oral-mucosa-clinical-and-histopathological-findings-review-of-the-literature-and-a-case-report
#9
Anna-Maija Matela, Jaana Hagström, Hellevi Ruokonen
OBJECTIVES: Lichen sclerosus (LS) is a rare, chronic mucocutaneous disease that most frequently affects the female genital area. Oral manifestations are seldom detected; only 36 well-documented and histopathologically verified oral LS cases have been published. MATERIALS AND METHODS: Here we describe one patient affected by oral (LS) and review of the literature 1957-2017. RESULTS: Findings in our review suggest a female to male ratio of 1...
April 16, 2018: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/29644193/nonvenereal-penile-dermatoses-a-retrospective-study
#10
Ana Marcos-Pinto, Luís Soares-de-Almeida, João Borges-Costa
Context: A variety of nonvenereal diseases can affect the penis and diminish quality of life. Many present similar clinical features and a cutaneous biopsy may be necessary to clarify the diagnosis. Aims: To characterize nonvenereal penile dermatoses with histological confirmation in a southwestern Europe hospital during a 9-year period. Materials and Methods: A retrospective study was conducted. We reviewed all penile biopsies performed between January 1, 2007 and December 31, 2015 and studied the causes of the nonvenereal penile dermatoses...
March 2018: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/29630161/bullous-lichen-sclerosus-isolated-vulvar-involvement
#11
Ayşe Kavak, Bilgen Erdoğan, Zeynep Topkarc, Hazal Sönmezler, Damlanur Sakız
We present a patient with the bullous form of lichen sclerosus of the vulva. She had no lesions in other cutaneous and mucosal areas. We used topical tacrolimus and topical clobetasol propionate. The patient was lesion free at the first-year follow-up.
February 15, 2018: Dermatology Online Journal
https://www.readbyqxmd.com/read/29601924/anterior-urethroplasty-using-a-new-tissue-engineered-oral-mucosa-graft-surgical-techniques-and-outcomes
#12
Guido Barbagli, Ilgar Akbarov, Axel Heidenreich, Vahudin Zugor, Roberto Olianas, Maurizio Aragona, Giuseppe Romano, Ulf Balsmeyer, Dirk Fahlenkamp, Udo Rebmann, Diana Standhaft, Massimo Lazzeri
PURPOSE: We investigated if the tissue-engineered material may be adopted using the standard techniques for anterior urethroplasty. MATERIALS AND METHOD: Retrospective, multicenter study including patients with recurrent strictures and excluding patients with failed hypospadias, lichen sclerosus, traumatic and posterior strictures. An oral mucosa biopsy of 0.5 cm2 was taken from patient's cheek and sent to the laboratory for manufacturing the graft. After 3 weeks, the tissue engineered oral mucosal graft (MukoCell®) was sent to the hospital for urethroplasty...
March 27, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29566925/genital-diseases-in-the-mature-woman
#13
Natalie Matthews, Vivian Wong, Joe Brooks, George Kroumpouzos
Vulvovaginal conditions are common in mature women. This reflects age-related changes in immunity and skin barrier function of vulvovaginal tissues. Vaginal atrophy is commonly complicated by dryness and inflammation, which makes postmenopausal atrophic vaginitis a virtually ubiquitous condition. The differential of vaginitis includes inflammatory, infectious, and malignant diseases, plus drug hypersensitivity. Atrophic vaginitis is treated with estrogen replacement therapy. Vulvovaginal malignant melanoma occurs predominantly in postmenopausal women and carries a poor prognosis...
March 2018: Clinics in Dermatology
https://www.readbyqxmd.com/read/29566881/extragenital-lichen-sclerosus-induced-by-radiotherapy
#14
M Bonfill-Ortí, L Martínez-Molina, R M Penín, J Marcoval
No abstract text is available yet for this article.
March 19, 2018: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/29564880/blue-diode-laser-a-new-strategy-for-the-management-of-lichen-sclerosus-et-atrophicus
#15
Nicola DI Meo, Katiuscia Nan, Cecilia Noal, Giulia Ottaviani, Matteo Biasotto, Giusto Trevisan
No abstract text is available yet for this article.
April 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29559206/retrospective-study-of-the-prevalence-and-risk-factors-of-clitoral-adhesions-women-s-health-providers-should-routinely-examine-the-glans-clitoris
#16
Leen Aerts, Rachel S Rubin, Michael Randazzo, Sue W Goldstein, Irwin Goldstein
INTRODUCTION: The glans clitoris is covered by a prepuce that normally moves over the glans surface and can be retracted beyond the corona. Clitoral adhesions, ranging from mild to severe, occur when preputial skin adheres to the glans. Physical examination consistent with clitoral adhesions is based on the inability to visualize the entire glans corona. In this closed compartment, the space underneath the adherent prepuce and clitoris can become irritated, erythematous, or infected and can result in sexual dysfunction...
March 17, 2018: Sexual Medicine
https://www.readbyqxmd.com/read/29555332/vulvar-cancer-two-pathways-with-different-localization-and-prognosis
#17
F Hinten, A Molijn, L Eckhardt, L F A G Massuger, W Quint, P Bult, J Bulten, W J G Melchers, J A de Hullu
BACKGROUND: Two etiologic pathways for vulvar squamous cell carcinoma (SCC) are described: in a background of lichen sclerosus and/or differentiated vulvar intraepithelial neoplasia and related to high-risk human papillomavirus (HPV) infection with high grade squamous intraepithelial lesion (HSIL) as precursor. The aim was to compare the predilection site and survival of HPV-related to non HPV-related vulvar SCCs. METHODS: Data of patients treated for primary vulvar SCC at the Radboudumc between March 1988 and January 2015 were analyzed...
May 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29534008/anti-inflammatory-and-tissue-regenerative-effects-of-topical-treatment-with-ozonated-olive-oil-vitamin-e-acetate-in-balanitis-xerotica-obliterans
#18
Monica Currò, Tiziana Russo, Nadia Ferlazzo, Daniela Caccamo, Pietro Antonuccio, Salvatore Arena, Saveria Parisi, Patrizia Perrone, Riccardo Ientile, Carmelo Romeo, Pietro Impellizzeri
Balanitis xerotica obliterans (BXO) is a chronic inflammatory skin disorder, considered the male genital variant of lichen sclerosus. Anti-inflammatory drugs are commonly used in BXO. We evaluated the effects of an innovative formulation of ozonated olive oil with vitamin E acetate (OZOILE® ) on the inflammatory status and tissue remodeling in male children with BXO. The mRNA transcripts of proteins involved either in inflammation or in dynamics of tissue regeneration were analyzed by quantitative real-time PCR, in foreskins affected by BXO removed from patients untreated or treated with OZOILE® cream for 7 days before circumcision...
March 13, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29524285/vulvar-neoplasms-in-275-women-with-genital-lichen-sclerosus-and-impact-of-treatment-a-retrospective-chart-review
#19
LETTER
E A Dell, R Y N Miest, C M Lohse, R R Torgerson
No abstract text is available yet for this article.
March 10, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29507565/high-frequency-ultrasonography-hfus-as-a-useful-tool-in-differentiating-between-plaque-morphea-and-extragenital-lichen-sclerosus-lesions
#20
Rafał Białynicki-Birula, Radomir Reszke, Jacek C Szepietowski
Introduction: Morphea and lichen sclerosus (LS) are chronic inflammatory diseases that may pose a diagnostic challenge for a physician. High-frequency ultrasonography (HFUS) is a versatile diagnostic method utilized in dermatologic practice, allowing monitoring the course of the disease, treatment response and differentiation between certain skin disorders. Aim: To prove the usefulness of HFUS in differentiating between plaque morphea and extragenital LS lesions...
October 2017: Postȩpy Dermatologii i Alergologii
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