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Lichen sclerosus

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https://www.readbyqxmd.com/read/28369011/comorbid-vulvar-lichen-planus-and-lichen-sclerosus
#1
Tania Day, Sarah Moore, Tanja Gizela Bohl, James Scurry
OBJECTIVES: The aims of the study are to assess the histopathologic characteristics of vulvar biopsies consistent with lichen planus (LP) in women with a previous or concurrent histopathologic diagnosis of vulvar lichen sclerosus (LS) and to describe the clinical features of comorbid LP and LS. MATERIALS AND METHODS: Patients were included if a diagnosis of LP was confirmed after review of the hematoxylin and eosin slides and the histopathology reporting LS noted a band of abnormal collagen...
March 31, 2017: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/28349117/anogenital-lichen-sclerosus-change-of-tissue-position-as-pathogenetic-factor
#2
Benjamin Wolf, Lars-Christian Horn, Michael Höckel
•Lichen sclerosus in females primarily involves the hairless anogenital skin.•Skin tissue outside this area is constitutionally not at risk for lichen sclerosus.•Transplantation into the vulvar field may turn skin susceptible to lichen sclerosus.•Tissue inherent positional information might affect lichen sclerosus susceptibility.
May 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28300903/extensive-bullous-lichen-sclerosus-et-atrophicus
#3
Jelica Vukicevic
Lichen sclerosus et atrophicus is a chronic disease of unknown etiology characterized by atrophic and sclerotic plaques in both genital and extragenital regions. Extensive bullous lichen sclerosus et atrophicus (BLSA) is a severe variant of the disease with no widely accepted treatment. We present a 63-year-old woman with extensive extragenital, ivory-colored, atrophic plaques on her trunk and extremities and disseminated hemorrhagic bullae. The patient was unsuccessfully treated with standard topical corticosteroid therapy, doxycycline and chloroquine...
September 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28293790/deconstructing-the-genitourinary-syndrome-of-menopause
#4
Pedro Vieira-Baptista, Claudia Marchitelli, Hope K Haefner, Gilbert Donders, Faustino Pérez-López
The concept of genitourinary syndrome of menopause (GSM) was recently introduced and has been gaining widespread use. While some justifications for its introduction are straightforward, others may be questionable. Numerous unspecific symptoms and signs were included in the definition of the syndrome, but the minimum number required for diagnosis was not established. While the GSM definition is designed to facilitate identifying vulvovaginal and urinary estrogen-deprivation-associated symptoms and signs, several concerns have evolved: (1) the syndrome may result in the underdiagnosis of vulvar and urinary pathology; and (2) serious conditions (e...
March 14, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28271552/localized-scleroderma-clinical-and-epidemiological-features-with-emphasis-on-adulthood-versus-childhood-onset-disease-differences
#5
REVIEW
A Lis-Święty, A Skrzypek-Salamon, I Ranosz-Janicka, L Brzezińska-Wcisło
BACKGROUND: Localized scleroderma is a rare inflammatory skin disorder that affects the skin and sometimes underlying subcutaneous tissue, muscles or bones. The disease has two modes of onset: juvenile- (JLS) and adult-onset (aLoS). Clinical features have impact on diagnostic and treatment recommendations, but no consensus on the disease management depending on the age at diagnosis was given. OBJECTIVE: To identify these features which differentiate aLoS from JLS...
March 8, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28259230/vulvovaginal-issues-in-mature-women
#6
REVIEW
Mary L Marnach, Rochelle R Torgerson
Mature women often present with symptomatic vulvovaginal atrophy and vulvar dermatoses, causing noncoital pain, dyspareunia, and sexual changes. Diagnosis of these conditions can be challenging, and long-term management is required to decrease morbidity and enhance quality of life. Vaginal estrogen therapies remain safe and effective for treating symptomatic vulvovaginal atrophy. A vulvar biopsy is easy to perform and generally well tolerated when indicated for the diagnosis of lichen simplex chronicus, lichen sclerosus, and lichen planus...
March 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/28244939/benign-atrophic-papulosis-degos-disease-with-lymphocytic-vasculitis-and-lichen-sclerosus-like-features
#7
Esther Kim, Kiran Motaparthi
Degos disease manifests as 2 distinct clinical variants, malignant atrophic papulosis and benign atrophic papulosis, which are distinguished by the presence or absence of systemic disease. Both forms feature cutaneous involvement typified by erythematous papules with scar-like centers, and the classic histologic picture is described as wedge-shaped dermal necrosis overlying thrombotic vasculopathy. However, the histopathology of early lesions is distinct and more variable. A case of benign atrophic papulosis with lymphocytic vasculitis and lichen sclerosus-like features is described, and the spectrum of histologic findings in Degos disease is reviewed...
February 14, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28244087/the-treatment-of-vulval-lichen-sclerosus-in-prepubertal-girls-a-critically-appraised-topic
#8
S Mashayekhi, C Flohr, F M Lewis
Lichen sclerosus is one of the dermatoses that specifically affects the anogenital skin. It has peaks of incidence in prepubertal girls and postmenopausal women. The objective of this critical appraisal was to review systematically the evidence for efficacy and safety of different treatments. There are no randomized controlled studies of treatment in prepubertal girls and most studies are small case series or case reports. There is little focus on quality of life.
February 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28239832/silk-textile-with-antimicrobial-aem5772-5-dermasilk-a-pilot-study-with-positive-influence-on-acne-vulgaris-on-the-back
#9
Caroline Schaunig, Daisy Kopera
BACKGROUND: The use of special silk textiles (Dermasilk) has shown positive effects on chronic inflammatory diseases like lichen sclerosus et atrophicus, atopic dermatitis, diabetic ulcerations, and vulvovaginal candidiasis. OBJECTIVE: Wearing T-shirts of this particular fabric could be useful in the management of patients with acne vulgaris on the back and trunk. MATERIAL AND METHODS: Dermasilk T-shirts were given to 14 patients with acne vulgaris papulopustulosa on the back...
February 27, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28219801/ala-photodynamic-treatment-in-lichen-sclerosus-clinical-and-immunological-outcome-focusing-on-the-assesment-of-anti-nuclear-antibodies
#10
Anita Olejek, Iwona Gabriel, Anna Bilska-Janosik, Iwona Kozak-Darmas, Aleksandra Kawczyk-Krupka
BACKGROUND: Lichen sclerosus (LS) is a difficult to treat, often relapsing disease with unknown background. An autoimmune diseases coexist with LS. Over recent years photodynamic therapy (PDT) has been shown to be noninvasive and successful therapeutic approach for the effective treatment many conditions. However, the change of immune status of the patients based on ANA antibodies has not been yet reported. Our aim was to observe the clinical response followed by possible changes in autoimmune antibodies levels before and after PDT...
February 17, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28217480/extragenital-lichen-sclerosus-et-atrophicus-co-exististing-with-pemphigus-vulgaris
#11
Chirag Desai, Utpal Durve, Uday Khopkar
No abstract text is available yet for this article.
January 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/28188018/surgical-treatment-of-disabling-conditions-caused-by-anogenital-lichen-sclerosus-in-women-an-account-of-surgical-procedures-and-results-including-patient-satisfaction-benefits-and-improvements-in-health-related-quality-of-life
#12
Filip Rangatchew, Jens Knudsen, Michael V Thomsen, Krzysztof T Drzewiecki
BACKGROUND: Anogenital lichen sclerosus (LS), a chronic dermatitis that causes scarring and introital stenosis, may prevent sexual intercourse and reduce health-related quality of life (QoL). Surgery can restore the anatomy, allowing patients to resume their sexual lives. This study investigates outcomes in women treated with local skin flaps. METHODS: Thirty-eight consecutive LS-verified patients, surgically treated for debilitating conditions between 1990 and 2013, were retrospectively evaluated...
April 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28161837/autologous-platelet-rich-plasma-prp-in-chronic-penile-lichen-sclerosus-the-impact-on-tissue-repair-and-patient-quality-of-life
#13
Francesco Casabona, Ilaria Gambelli, Federica Casabona, Pierluigi Santi, Gregorio Santori, Ilaria Baldelli
PURPOSE: Lichen sclerosus (LS) is a chronic inflammatory skin condition that frequently involves the anogenital region. Ongoing research is focused on finding more effective treatments for tissue repair and reducing symptoms. The aim of this study is to evaluate the effectiveness of platelet-rich plasma (PRP) local injections in penile LS. METHODS: Forty-five male patients affected by penile LS underwent injections of autologous PRP in the affected skin areas. Age at diagnosis and at first treatment, number of treatments, clinical conditions (phimosis, splitting, inflammation, synechiae, meatus stenosis), symptoms (pain, burning, itching), and functional impairment were considered...
April 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28134725/sclerosing-dermatofibrosarcoma-protuberans-shows-significant-overlap-with-sclerotic-fibroma-in-both-routine-and-immunohistochemical-analysis-a-potential-diagnostic-pitfall
#14
Maram Yousef Odeh Abdaljaleel, Jeffrey P North
Dermatofibrosarcoma protuberans (DFSP) is an uncommon, low-to-intermediate grade sarcoma with several histologic variants, including pigmented (Bednar tumor), sclerosing, myxoid, atrophic, and DFSP with fibrosarcomatous changes. Two patterns of sclerosis in DFSP can be observed, a sclerotic fibroma-like pattern and a morphea/lichen sclerosus-like pattern. Partial biopsies of sclerosing DFSPs with the sclerotic fibroma pattern can be misdiagnosed as sclerotic fibroma or other benign sclerosing tumors (eg, perineurioma, dermatofibroma)...
February 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28124469/lichen-sclerosus-and-risk-of-cancer
#15
Pia Halonen, Maija Jakobsson, Oskari Heikinheimo, Annika Riska, Mika Gissler, Eero Pukkala
Malignant potential of lichen sclerosus (LS) has been suspected, but evidence is sparse. We used the population-based Finnish Cancer Registry data to further study this connection. We identified all women with the diagnosis of LS (n = 7,616) listed in the Finnish Hospital Discharge Registry from 1970 to 2012. The cohort was followed through the Finnish Cancer Registry for subsequent cancer diagnoses until 2014. Standardized incidence ratios (SIRs) were calculated for different cancers by dividing the observed numbers of cancers by expected ones...
May 1, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28108798/augmented-perineal-urethrostomy-using-a-dorsal-buccal-mucosal-graft-bi-institutional-study
#16
Jessica DeLong, Kurt McCammon, Leandro Capiel, Augustín Rovegno, Jeremy B Tonkin, Gerald Jordan, Ramón Virasoro
PURPOSE: To present our technique and outcomes for perineal urethrostomy augmented with a dorsal onlay buccal mucosa graft (BMG). Results from initial series and collaboration from an international center are included. METHODS: A retrospective chart review of all adult patients who underwent urethral reconstruction with perineal urethrostomy utilizing a buccal mucosal graft between January 1, 2002 and January 1, 2013 was performed. All surgeries were performed by three surgeons using the same technique (GHJ, KAM, and RV)...
January 20, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28087029/lichen-sclerosus-of-the-glans-simulating-melanoma
#17
Pietro Sollena, Giacomo Caldarola, Alessandro Di Stefani, Guido Massi, Ketty Peris
No abstract text is available yet for this article.
February 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28043767/bleeding-after-circumcision-is-more-likely-in-children-with-lichen-sclerosus-balanitis-xerotica-obliterans
#18
P Somov, B K Y Chan, C Wilde, H Corbett
INTRODUCTION: Over 27,000 circumcisions were performed in England in 2012-13. The complication rate is generally perceived to be low, although published figures vary widely. Balanitis xerotica obliterans, more correctly termed Lichen Sclerosus et atrophicus (LS), is one of the commonest indications for medical circumcision. To test the hypothesis that children undergoing circumcision for LS have a higher rate of postoperative bleeding than those undergoing the procedure for other reasons, we retrospectively reviewed records for patients undergoing circumcision...
December 9, 2016: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28024127/combined-therapy-in-vulvar-lichen-sclerosus-does-topical-tretinoin-improve-the-efficacy-of-mometasone-furoate
#19
Alessandro Borghi, Sara Minghetti, Giulia Toni, Annarosa Virgili, Monica Corazza
Purpose To assess efficacy and safety profile of combining a potent corticosteroid with a retinoid in in the treatment of vulvar lichen sclerosus (VLS). Methods We retrospectively compared 21 VLS patients treated with tretinoin (T) in short contact therapy and mometasone furoate (MMF) (group A) and 20 treated with cold cream (CC) and MMF (group B) for 5 consecutive days/week for 12 weeks. The efficacy parameters were the response rate, the percentage of patients achieving an improvement from baseline of ≥75% in subjective and objective scores, and the mean reduction in subjective and objective scores...
December 26, 2016: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/27989640/commentary-to-bleeding-after-circumcision-is-more-likely-in-children-with-lichen-sclerosus-facts-are-stubborn-but-statistics-are-more-pliable
#20
Anne-Françoise Spinoit
No abstract text is available yet for this article.
December 5, 2016: Journal of Pediatric Urology
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