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Lichen sclerosus

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https://www.readbyqxmd.com/read/29140882/extravascular-migratory-metastasis-pericytic-mimicry-in-sarcomatoid-squamous-cell-carcinoma-of-the-vulva-a-report-of-2-cases
#1
M H Eleanor Koay, Colin J R Stewart
Extravascular migratory metastasis (EVMM), also known as pericytic mimicry or angiotropism, is a mechanism of angiocentric tumor spread that has been investigated mainly in cutaneous malignant melanoma where it has been associated with an increased risk of metastasis. In EVMM, the tumor cells spread along the external (ablumenal) aspect of vessels without breaching the endothelium, a process that is therefore distinct from the more widely recognized intraluminal invasion. Although EVMM has also been reported in a limited range of other tumor types, to our knowledge it has not been described in squamous cell carcinoma (SCC)...
November 14, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29137809/prognostic-factors-for-local-recurrence-of-squamous-cell-carcinoma-of-the-vulva-a-systematic-review
#2
Nienke C Te Grootenhuis, Anne-Floor W Pouwer, Geertruida H de Bock, Harry Hollema, Johan Bulten, Ate G J van der Zee, Joanne A de Hullu, Maaike H M Oonk
BACKGROUND: In patients treated for early-stage squamous cell vulvar carcinoma local recurrence is reported in up to 40% after ten years. Knowledge on prognostic factors related to local recurrences should be helpful to select high risk patients and/or to develop strategies to prevent local recurrences. OBJECTIVE: This systematic review aims to evaluate the current knowledge on the incidence of local recurrences in vulvar carcinoma related to clinicopathologic and cell biologic variables...
November 11, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29126556/vulvar-intraepithelial-neoplasia-risk-factors-for-recurrence
#3
W Satmary, C H Holschneider, L L Brunette, S Natarajan
OBJECTIVE: We studied a large population of women with high-grade vulvar intraepithelial neoplasia (VIN) in order to identify patient and treatment-related risk factors for recurrence and progression to cancer. METHODS: For this retrospective cohort study of women with a histologic diagnosis of VIN within Southern California Permanente Medical Group between 1995 and 2007 medical records were reviewed; clinical, demographic and pathologic data were collected. Statistical analyses included Chi-squared and Student's t-tests, univariate and multivariate logistic regression, and cumulative incidence analysis...
November 7, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29107132/staged-urethroplasty-for-penile-urethral-strictures-from-lichen-sclerosus-and-failed-hypospadias-repair
#4
Bradley D Figler, Andrew Gomella, Logan Hubbard
OBJECTIVE: To present our technique for staged urethroplasty with buccal mucosa graft. METHODS: The patient presented is a 42 year-old male with a history of congenital hypospadias repaired as a child. He developed a penile urethral stricture at age 30 and was managed with self intermittent dilation. Recently, dilation became more difficult, and he was referred for reconstruction. Work-up revealed a high-grade stricture extending from the meatus to the site of the previous anastomosis at the penoscrotal junction...
October 26, 2017: Urology
https://www.readbyqxmd.com/read/29095746/development-of-the-adult-vulvar-lichen-sclerosus-severity-scale-a-delphi-consensus-exercise-for-item-generation
#5
Michal Sheinis, Amanda Selk
OBJECTIVE: To generate a list of items through international expert consensus consisting of both symptoms and clinical signs for inclusion in an adult vulvar lichen sclerosus severity scale. METHODS: This study was carried out as a three-stage Delphi consensus exercise. After an extensive literature review, any items used to determine disease severity in previous clinical trials were compiled into a survey. The Delphi participants were recruited from the International Society for the Study of Vulvovaginal Disease most of whom were gynecologists and in practice for more than 20 years...
November 1, 2017: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/29025691/morphea-and-extragenital-lichen-sclerosus-et-atrophicus-after-influenza-vaccination
#6
S Requena López, Y Hidalgo García, S Gómez Díez, B Vivanco Allende
No abstract text is available yet for this article.
October 9, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/29017363/a-survey-on-the-use-of-topical-steroids-in-patients-treated-for-lichen-sclerosus-associated-vulval-squamous-cell-carcinoma
#7
Rachel Pounds, Sanna Tahir, Christopher Dawson, Ciaran Woodman, David Luesley, Jason Yap
Evidence suggests that lichen sclerosus (LS) is the primary aetiological factor for local vulval recurrence (LVR) in vulval squamous cell carcinoma (VSCC). The long-term application of topical corticosteroids is believed to prevent LVR. Patients treated for LS-associated VSCC at a gynaecological cancer centre were invited to complete a questionnaire to evaluate whether they are receiving corticosteroids. 55 of the 95 eligible patients (58%) completed the questionnaire; LS was treated in 69%, with steroids given to 84...
October 10, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28940561/folliculocentric-hyperkeratotic-lichen-sclerosus-in-a-7-year-old-child-successfully-treated-with-narrowband-ultraviolet-b-phototherapy
#8
T K Uzuncakmak, N Akdeniz, H Suslu, E Zemheri, A S Karadag
No abstract text is available yet for this article.
September 20, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28932316/penile-melanosis-associated-with-lichen-sclerosus-et-atrophicus-first-description-in-the-medical-literature
#9
Georgi Tchernev, Anastasiya Atanasova Chokoeva, Hristo Mangarov
We present a 74-year-old male patient with 3-years history of visible discoloration of the glans penis, without subjective complaints. Histopathological examination after incision biopsy revealed a moderate increase in the number of melanocytes in the basal layer with irregular distribution, without melanocytic nests, melanophages in the superficial dermis, and subepidermal sclerosus. No cytologic atypia of melanocytes was detectable. The diagnosis of melanosis of the genitalia in association with lichen sclerosus was made...
August 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28892974/squamous-cell-carcinoma-penis-in-a-case-of-urethral-stricture-due-to-lichen-sclerosus-balanitis-xerotica-obliterans-a-case-report-and-review-of-literature
#10
Yogesh Taneja, Priyatama Ram, Santosh Kumar Dhaked, Tridib Kumar Sen
Penile carcinoma is considered a delayed sequel of lichen sclerosus. It is important to recognize this not so uncommon complication in time as survival of patients with Squamous Cell Carcinoma (SCC) depends on early diagnosis and treatment. We describe a case of a 49-year-old male presenting with urethral stricture due to lichen sclerosus. He was treated for stricture disease and later on developed SCC penis after ten years of presentation.
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28884911/final-diagnosis-of-112-girls-presenting-with-genital-mucocutaneous-symptoms-and-signs-the-mayo-clinic-experience
#11
Caoimhe M R Fahy, Rochelle R Torgerson, Mark D P Davis
Pediatric genital mucocutaneous diseases are rare. A retrospective review was performed of children presenting with symptomatology of genital dermatoses to a hospital-based dermatology service. This study highlights that the range of genital diseases in children is not as broad as in adults. The diagnosis of genital mucocutaneous disease in children is usually genital lichen sclerosus, but other diagnoses should be considered.
September 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28877300/a-transgender-woman-with-anogenital-lichen-sclerosus
#12
Stacy L McMurray, Emily Overholser, Tejesh Patel
No abstract text is available yet for this article.
September 6, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28867463/oral-lichen-sclerosus-a-review-of-clinical-presentation-treatment-and-clinical-outcomes
#13
REVIEW
Stephanie L Bevans, Jordan M Keeley, Naveed Sami
OBJECTIVE: The aim of this study was to evaluate the disease involvement, treatment and response, and malignant potential of oral lichen sclerosus (LS). STUDY DESIGN: We conducted a review of the literature of 37 cases of oral LS. We looked specifically for the following data: patient demographic characteristics, disease involvement, treatment, response to treatment, duration of follow-up, symptoms, risk factors for oral malignancy, and malignant transformation...
October 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28856863/short-and-long-term-efficacy-of-focused-ultrasound-therapy-for-non-neoplastic-epithelial-disorders-of-the-vulva
#14
C Wu, M Zou, Y Xiong, L Wang, H Chen, Y Fan, C Li
OBJECTIVE: To investigate the short- and long-term efficacy and influential factors of focused ultrasound for the treatment of non-neoplastic epithelial disorders of the vulva (NNEDV). DESIGN: A retrospective observational study. SETTING: A gynaecologic department in a single centre in China. POPULATION: Patients with NNEDV were included in this study: 85 patients were diagnosed with lichen simplex chronicus (LSC), 44 patients with vulva lichen sclerosus (VLS), and seven patients with lichen planus (LP)...
August 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28856426/genital-lichen-sclerosus-in-childhood-and-adolescence-a-retrospective-case-series-of-15-patients-early-diagnosis-is-crucial-to-avoid-long-term-sequelae
#15
Ioannis Nerantzoulis, Themistoklis Grigoriadis, Lina Michala
Lichen sclerosus is a chronic skin disease, mainly localised at the introitus and perineum. When the condition remains untreated, gradual atrophy of skin structures leads to permanent scarring, making early diagnosis and treatment crucial. We reviewed all patients diagnosed with lichen sclerosus presenting to a tertiary referral centre for paediatric and adolescent gynaecology between January 2011 and December 2015 to assess disease presentation and response to treatment. We identified 15 cases, with a mean age at diagnosis of 8...
October 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28831422/laser-treatment-of-medical-skin-disease-in-women
#16
REVIEW
C LaRosa, A Chiaravalloti, S Jinna, W Berger, J Finch
Laser treatment is a relatively new and increasingly popular modality for the treatment of many dermatologic conditions. A number of conditions that predominantly occur in women and that have a paucity of effective treatments include rosacea, connective tissue disease, melasma, nevus of Ota, lichen sclerosus (LS), notalgia paresthetica and macular amyloidosis, and syringomas. Laser therapy is an important option for the treatment of patients with these conditions. This article will review the body of literature that exists for the laser treatment of women with these medical conditions...
September 2017: International Journal of Women's Dermatology
https://www.readbyqxmd.com/read/28826876/does-circumcision-increase-meatal-stenosis-risk-a-systematic-review-and-meta-analysis
#17
REVIEW
Brian J Morris, John N Krieger
CONTEXT: Meatal stenosis (MS) as a potential complication of male circumcision and controversy regarding the magnitude of risk. OBJECTIVES: To conduct a systematic review and meta-analyses to assess (1) MS diagnosis after circumcision, (2) the potential association of MS with circumcision, and (3) a potential method of prevention. DATA SOURCES: PubMed, Google Scholar, Cochrane Library and bibliographies of original studies were searched using the keywords circumcision and stenosis or stricture...
August 4, 2017: Urology
https://www.readbyqxmd.com/read/28820401/intraepidermal-nerve-fiber-density-in-vulvar-lichen-sclerosus-and-normal-vulvar-tissues
#18
K Milian-Ciesielska, L Chmura, G Dyduch, C Jagers, E Radwanska, D Adamek
Lichen sclerosus (LS) is a chronic and inflammatory disease causing sensory symptoms such as itch and pain and affecting most frequently genital skin of women. Intraepidermal nerve fiber density (IENFD) was examined immunohistologically in 20 vulvar skin biopsies of patients affected by LS and in 20 control vulvar skin biopsies, in order to determine if these sensory sensations originate in changes in the epidermal innervation. Obtained results show fewer protein gene product 9.5 (PGP 9.5) positive intraepidermal nerve fibers (IENF) in LS tissues compared to controls (P = 0...
June 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/28801716/-plastic-surgery-reconstruction-of-the-adult-buried-penis-option-or-obligation
#19
REVIEW
S Mühlstädt, P Anheuser, N Mohammed, A D Bach
The adult buried penis afflicts the patient with shame and is also potentially associated with considerable urogenital complications. Due to obesity, chronic urogenital lymphedema or subsequent inflammatory urogenital conditions, such as a lichen sclerosus et atrophicus, the clinical appearance of the adult buried penis is extremely variable. Epidemiological data are non-existent. Therapeutically, a combination of various plastic surgery procedures is often necessary for the best esthetic and functional results...
October 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/28796915/clearance-in-vulvar-lichen-sclerosus-a-realistic-treatment-endpoint-or-a-chimera
#20
A Borghi, A Virgili, S Minghetti, G Toni, M Corazza
BACKGROUND: according to the current guidelines, the aim of vulvar lichen sclerosus (VLS) treatment is to improve symptoms and signs, not to cure. OBJECTIVE: to assess i) the rate of VLS patients who achieved complete clearance of symptoms or objective features, or both, with a 12-week pharmacological treatment and ii) the predictive value of therapeutic response of the demographic and clinical features. METHODS: we retrospectively included VLS patients who had undergone any topical treatment for 12 weeks; demographics, history, VLS-related symptoms and objective features recorded at baseline and on completion of treatment were collected and elaborated...
August 10, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
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