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https://www.readbyqxmd.com/read/29049744/extended-pleurectomy-decortication-for-malignant-pleural-mesothelioma-in-the-elderly-the-need-for-an-inclusive-yet-selective-approach
#1
Annabel Jane Sharkey, Rocco Bilancia, Sara Tenconi, Apostolos Nakas, David A Waller
OBJECTIVES: The median age at diagnosis of patients with pleural mesothelioma in the UK is 73 years. Recent series have shown the feasibility of extended pleurectomy decortication in the elderly, but with continuing debate about the efficacy of this treatment, we reviewed our experience to identify more detailed selection criteria. METHODS: We reviewed prospectively collected data on all patients from 1999 to 2016 undergoing extended pleurectomy decortication...
July 21, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29049477/association-of-the-addition-of-oral-antibiotics-to-mechanical-bowel-preparation-for-left-colon-and-rectal-cancer-resections-with-reduction-of-surgical-site-infections
#2
Elaine Vo, Nader N Massarweh, Christy Y Chai, Hop S Tran Cao, Nader Zamani, Sherry Abraham, Kafayat Adigun, Samir S Awad
Importance: Surgical site infections (SSIs) after colorectal surgery remain a significant complication, particularly for patients with cancer, because they can delay the administration of adjuvant therapy. A combination of oral antibiotics and mechanical bowel preparation (MBP) is a potential, yet controversial, SSI prevention strategy. Objective: To determine the association of the addition of oral antibiotics to MBP with preventing SSIs in left colon and rectal cancer resections and its association with the timely administration of adjuvant therapy...
October 18, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/29049462/association-of-surgical-approach-and-margin-status-with-oncologic-outcomes-following-gross-total-resection-for-sinonasal-melanoma
#3
Zafar Sayed, Jocelyn C Migliacci, Jennifer R Cracchiolo, Christopher A Barker, Nancy Y Lee, Sean M McBride, Viviane S Tabar, Ian Ganly, Snehal G Patel, Luc T Morris, Benjamin R Roman, Alexander N Shoushtari, Marc A Cohen
Importance: Sinonasal mucosal melanoma (SMM) is a rare malignant neoplasm characterized by a poor prognosis despite aggressive intervention including wide surgical resection. Margin status has previously been cited as an important prognostic factor for local control and overall survival (OS) in patients who undergo either an open or endoscopic surgical approach. No comparisons have been made, however, in patients who have undergone gross total resection with or without positive margins...
October 19, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29049091/tumor-microenvironment-and-models-of-ovarian-cancer-the-11th-biennial-rivkin-center-ovarian-cancer-research-symposium
#4
Karen McLean, Geeta Mehta
OBJECTIVE: The aim of this study was to review the latest research advances on the topics of the ovarian cancer tumor microenvironment and models of ovarian cancer. METHODS: In September 2016, a symposium of the leaders in the field of ovarian cancer research was convened to present and discuss current advances and future directions in ovarian cancer research. RESULTS: One session was dedicated to Tumor Microenvironment and Models of Ovarian Cancer, and included a keynote presentation from Anil Sood, MD, and an invited oral presentation from David Huntsman, MD...
October 18, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29048211/ureteroscopy-in-patients-with-bleeding-diathesis-a-systematic-review-and-meta-analysis-of-the-literature
#5
Ala'a Sharaf, Tarik Amer, Bhaskar Somani, Omar M Aboumarzouk
Ureteroscopy (URS) is the most common surgical treatment of urolithiasis and can be problematic in patients with a bleeding diathesis. The intent of this review is to systematically review the literature to assess the safety and efficacy of ureteroscopic procedures in these groups of patients. Methods The systematic review was performed according to the Cochrane diagnostic accuracy reviews guidelines. The search strategy was conducted to perform a comprehensive database search (1990-2017). A cumulative analysis was done and where applicable a comparative analysis between bleeding diathesis patients and those without...
October 19, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/29046958/laparoscopic-choledochoduodenostomy-as-a-reliable-rescue-procedure-for-complicated-bile-duct-stones
#6
Palanisamy Senthilnathan, Dhawal Sharma, Sandeep C Sabnis, S Srivatsan Gurumurthy, E Senthil Anand, V P Nalankilli, Natesan Anand Vijai, Palanivelu Praveen Raj, Ramakrishnan Parthasarathy, Subbaiah Rajapandian, Chinnusamy Palanivelu
BACKGROUND: Endoscopic retrograde cholangiopancreatography (ERCP) with stone extraction is generally accepted as first line management for common bile duct (CBD) stones. CBD exploration, either by open or laparoscopic approach nowadays, is usually reserved for ERCP failures, complicated stone locations, along with altered anatomical situations. The aim of this study was to highlight the increasing role of laparoscopic choledochoduodenostomy which is not only a reliable but also as a rescue procedure for those failed ERCP cases due to complicated bile duct stones...
October 18, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29045765/oral-anti-diabetic-agents-for-women-with-established-diabetes-impaired-glucose-tolerance-or-previous-gestational-diabetes-planning-pregnancy-or-pregnant-women-with-pre-existing-diabetes
#7
REVIEW
Joanna Tieu, Suzette Coat, William Hague, Philippa Middleton, Emily Shepherd
BACKGROUND: While most guidance recommends the use of insulin in women whose pregnancies are affected by pre-existing diabetes, oral anti-diabetic agents may be more acceptable to women. The effects of these oral anti-diabetic agents on maternal and infant health outcomes need to be established in pregnant women with pre-existing diabetes or impaired glucose tolerance, as well as in women with previous gestational diabetes mellitus preconceptionally or during a subsequent pregnancy. OBJECTIVES: To investigate the effects of oral anti-diabetic agents in women with established diabetes, impaired glucose tolerance or previous gestational diabetes who are planning a pregnancy, or pregnant women with pre-existing diabetes, on maternal and infant health...
October 18, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29045750/aging-and-hiv-related-caregiving-in-sub-saharan-africa-a-social-ecological-approach
#8
Jeon Small, Carolyn Aldwin, Paul Kowal, Somnath Chatterji, Rachel Pruchno
Background and Objectives: We reviewed the literature on older adults (OAs) who are caring for persons living with HIV/AIDS in sub-Saharan Africa (SSA), with the goal of adapting models of caregiver stress and coping to include culturally relevant and contextually appropriate factors specific to SSA, drawing on both life course and cultural capital theories. Research Design and Methods: A systematic literature search found 81 articles published between 1975 and 2016 which were reviewed using a narrative approach...
October 17, 2017: Gerontologist
https://www.readbyqxmd.com/read/29044993/intra-articular-hyaluronic-acid-injection-in-treating-knee-osteoarthritis-assessing-risk-of-bias-in-systematic-reviews-with-robis-tool
#9
Dan Xing, Bin Wang, Wei Zhang, Ziyi Yang, Yunfei Hou, Yaolong Chen, Jianhao Lin
OBJECTIVES: Intra-articular injection of hyaluronic acid (HA) is a common, yet controversial therapeutic option in treating knee osteoarthritis (OA). The purpose of the present study was to assess the risk of bias (RoB) of systematic reviews (SRs) and to summarize available evidence of HA in treating knee OA. METHODS: A systematic search of SRs published through to December 2016 was conducted using the MEDLINE, EMBASE and Cochrane Library. The RoB of included SRs was assessed by ROBIS tool...
October 17, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29044676/world-health-organization-defined-eosinophilic-disorders-2017-update-on-diagnosis-risk-stratification-and-management
#10
Jason Gotlib
DISEASE OVERVIEW: The eosinophilias encompass a broad range of nonhematologic (secondary or reactive) and hematologic (primary, clonal) disorders with potential for end-organ damage. DIAGNOSIS: Hypereosinophilia has generally been defined as a peripheral blood eosinophil count greater than 1500/mm(3) and may be associated with tissue damage. After exclusion of secondary causes of eosinophilia, diagnostic evaluation of primary eosinophilias relies on a combination of morphologic review of the blood and marrow, standard cytogenetics, fluorescent in situ-hybridization, flow immunocytometry, and T-cell clonality assessment to detect histopathologic or clonal evidence for an acute or chronic myeloid or lymphoproliferative disorder...
November 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/29043850/age-adjusted-d-dimer-cut-off-in-the-diagnostic-strategy-for-deep-vein-thrombosis-a-systematic-review
#11
Mads Nybo, Anne-Mette Hvas
BACKGROUND: Studies have indicated that use of an age-adjusted D-dimer cut-off value for patients above 50 years increases utility of the diagnostic strategy for pulmonary embolism. Evidence for the same approach regarding diagnosis of deep vein thrombosis (DVT) is, however, unclear. MATERIALS AND METHODS: A systematic literature review was conducted following the PRISMA Statement guideline to gather the existing knowledge on the use of an age-adjusted D-dimer cut-off in the diagnostic strategy for DVT...
October 18, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29042383/health-education-for-patients-with-acute-coronary-syndrome-and-type-2-diabetes-mellitus-an-umbrella-review-of-systematic-reviews-and-meta-analyses
#12
Xian-Liang Liu, Yan Shi, Karen Willis, Chiung-Jung Jo Wu, Maree Johnson
OBJECTIVES: This umbrella review aimed to identify the current evidence on health education-related interventions for patients with acute coronary syndrome (ACS) or type two diabetes mellitus (T2DM); identify the educational content, delivery methods, intensity, duration and setting required. The purpose was to provide recommendations for educational interventions for high-risk patients with both ACS and T2DM. DESIGN: Umbrella review of systematic reviews and meta-analyses...
October 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/29040711/diagnosis-and-outcome-of-biopsies-of-indeterminate-lesions-of-the-cavernous-sinus-and-meckel-s-cave-a-retrospective-case-series-in-85-patients
#13
Joshua D Hughes, Joseph Kapurch, Jamie J Van Gompel, Fredric B Meyer, Bruce E Pollock, John Atkinson, Michael J Link
BACKGROUND: When clinical presentation, laboratory studies, or imaging cannot diagnose cavernous sinus (CS) and/or Meckel's cave (MC) lesions, biopsy may be necessary. OBJECTIVE: To review our institutional series of biopsies of indeterminate CS and MC lesions. METHODS: Records from January 1994 to June 2016 were searched for biopsied indeterminate CS and MC lesions. We defined indeterminate as having an atypical imaging appearance or a broad differential and the need for tissue for definitive diagnosis...
October 11, 2017: Neurosurgery
https://www.readbyqxmd.com/read/29040698/clinical-outcome-after-endoscopic-endonasal-resection-of-tuberculum-sella-meningiomas
#14
Khaled Elshazly, Varun R Kshettry, Christopher J Farrell, Gurston Nyquist, Marc Rosen, James J Evans
BACKGROUND: In select cases, the endoscopic endonasal approach (EEA) has distinct advantages for resection of tuberculum sella meningiomas (TSM). OBJECTIVE: To report the extent of resection (EOR), complication rates, and outcomes in a large series of TSM treated by the EEA. METHODS: Twenty-five consecutive TSM cases treated by EEA from 2008 to 2016 were retrospectively reviewed. Patient history, imaging, volumetric EOR, complications, and outcomes are presented...
October 10, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29040257/current-challenges-in-the-management-of-essential-thrombocythemia
#15
Ariel Kleman, Arun K Singavi, Laura C Michaelis
Essential thrombocythemia (ET), an uncommon blood cancer, is one of the classic myeloproliferative neoplasms, a category that also includes polycythemia vera and primary myelofibrosis. All 3 diseases are clonal hematopoietic stem cell disorders. Since 2005, when scientists discovered a molecular aberration driving clonal hematopoiesis in polycythemia vera, our understanding of the genomic underpinnings of these conditions has increased rapidly. Over the last decades, primary prevention of thrombotic and hemorrhagic complications has improved the lives of patients with ET, and the ability to characterize the disease by the presence or absence of molecular mutations has lent precision to our prognostic models...
October 2017: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/29038894/the-supraorbital-eyebrow-approach-for-removal-of-craniopharyngioma-in-children-a-case-series
#16
Ricardo Santos de Oliveira, Dinark Conceição Viana, Lucas Pires Augusto, Marcelo Volpon Santos, Hélio Rubens Machado
OBJECTIVE: Craniopharyngiomas can be a surgical challenge for the pediatric neurosurgeon. Ideally, total removal must be achieved. However, the need to reduce surgical morbidity and preserve quality of life has led to a number of neurosurgical approaches in order to attain this goal. The aim of this article is to present an alternative surgical approach to these lesions and to provide the rationale for this technique. MATERIAL AND METHODS: Medical charts and operative records of eight pediatric patients harboring craniopharyngiomas who underwent surgical treatment using a supraorbital eyebrow approach (SOA) were reviewed from 2014 to 2016...
October 16, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29038188/probiotics-administered-intravaginally-as-a-complementary-therapy-combined-with-antibiotics-for-the-treatment-of-bacterial-vaginosis-a-systematic-review-protocol
#17
Liyan Ma, Jianrong Su, Yanli Su, Wei Sun, Zhaoying Zeng
INTRODUCTION: Bacterial vaginosis (BV) is a highly prevalent vaginal polymicrobial disorder commonly encountered in women of childbearing age. Therapy with only recommended antibiotics results in low cure rates and unacceptably high recurrence rates. The use of probiotics as a complementary approach for use with antibiotics for the treatment of BV remains unclear. This review aims to assess the efficacy of lactobacilli administered intravaginally in conjunction with antibiotics for the treatment of BV...
October 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/29037485/a-tale-of-two-pregnancies-a-critical-interpretive-synthesis-of-women-s-perceptions-about-delayed-initiation-of-antenatal-care
#18
REVIEW
Rosalind Haddrill
BACKGROUND: Delayed access to antenatal care in high income countries is associated with poor maternal, fetal and neonatal outcomes. The aim was to synthesise the diverse body of evidence around women's views of early antenatal care and barriers to attendance in such countries. Critical Interpretive Synthesis integrates the process of systematic review with the qualitative methods of meta-ethnography and grounded theory, with a focus on theory generation to inform policy, practice and future research...
October 13, 2017: Women and Birth: Journal of the Australian College of Midwives
https://www.readbyqxmd.com/read/29037194/a-posterior-versus-anterior-debridement-in-combination-with-bone-graft-and-internal-fixation-for-lumbar-and-thoracic-tuberculosis
#19
Yu Huang, Jin Lin, Xuanwei Chen, Jianhua Lin, Yulan Lin, Hongjie Zhang
BACKGROUND: Surgery treatment is usually required for spinal tuberculosis. The aim of this study was to compare the clinical efficacy and outcomes of anterior and posterior surgical approach in combination with debridement, bone grafting, and internal fixation. METHODS: All patients with thoracic and lumbar tuberculosis who underwent either the anterior or posterior surgery in combination with debridement, bone grafting, and internal fixation from August 2009 to August 2016 were reviewed retrospectively...
October 16, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29036283/the-science-of-absent-evidence-is-there-such-thing-as-an-effective-responsible-drinking-message
#20
Antony C Moss, Ian P Albery
Aims: To review the effectiveness of responsible drinking messages (RDMs). Methods: We searched PsycINFO, MEDLINE and Google Scholar to June 2016 for studies evaluating the effectiveness of RDMs. Only eight studies met the inclusion/exclusion criteria. Due to a small number of search results and broad inconsistency in methods and outcome measures, quantitative synthesis was not possible so a narrative summary of findings was conducted. Results: A review of findings from these articles suggested a disjointed approach in terms of the format and content of RDMs evaluated, as well as the dependent variables used to judge their effectiveness...
September 20, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
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