Martha Sajatovic, Soham Rej, Osvaldo P Almeida, Kursat Altinbas, Vicent Balanzá-Martínez, Izabela G Barbosa, Alexandra J M Beunders, Hilary P Blumberg, Farren B S Briggs, Annemiek Dols, Brent P Forester, Orestes V Forlenza, Ariel G Gildengers, Esther Jimenez, Federica Klaus, Beny Lafer, Benoit Mulsant, Benson Mwangi, Paula Villela Nunes, Andrew T Olagunju, Stephen Oluwaniyi, Melis Orhan, Regan E Patrick, Joaquim Radua, Tarek Rajji, Kaylee Sarna, Sigfried Schouws, Christian Simhandl, Harmehr Sekhon, Jair C Soares, Ashley N Sutherland, Antonio L Teixeira, Shangying Tsai, Sonia Vidal-Rubio, Eduard Vieta, Joy Yala, Lisa T Eyler
OBJECTIVES: The Global Aging & Geriatric Experiments in Bipolar Disorder Database (GAGE-BD) project pools archival datasets on older age bipolar disorder (OABD). An initial Wave 1 (W1; n = 1369) analysis found both manic and depressive symptoms reduced among older patients. To replicate this finding, we gathered an independent Wave 2 (W2; n = 1232, mean ± standard deviation age 47.2 ± 13.5, 65% women, 49% aged over 50) dataset. DESIGN/METHODS: Using mixed models with random effects for cohort, we examined associations between BD symptoms, somatic burden and age and the contribution of these to functioning in W2 and the combined W1 + W2 sample (n = 2601)...
March 2024: International Journal of Geriatric Psychiatry