In-Jeong Kim, Michael P Tighe, Madeline J Clark, Gregory D Gromowski, Paula A Lanthier, Kelsey L Travis, Derek T Bernacki, Tres S Cookenham, Kathleen G Lanzer, Frank M Szaba, Manasi A Tamhankar, Corrina N Ross, Suzette D Tardif, Donna Layne-Colon, Edward J Dick, Olga Gonzalez, Maria I Giraldo Giraldo, Jean L Patterson, Marcia A Blackman
Zika virus (ZIKV) infection during pregnancy causes severe developmental defects in newborns, termed congenital Zika syndrome (CZS). Factors contributing to a surge in ZIKV-associated CZS are poorly understood. One possibility is that ZIKV may exploit the antibody-dependent enhancement of infection mechanism, mediated by cross-reactive antibodies from prior dengue virus (DENV) infection, which may exacerbate ZIKV infection during pregnancy. In this study, we investigated the impact of prior DENV infection or no DENV infection on ZIKV pathogenesis during pregnancy in a total of four female common marmosets with five or six fetuses per group...
June 7, 2023: Science Translational Medicine