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https://www.readbyqxmd.com/read/28942698/neuroimaging-findings-using-transfontanellar-ultrasound-in-newborns-with-microcephaly-a-possible-association-with-congenital-zika-virus-infection
#1
Ana Sofia França Cruz Ximenes, Pedro Pires, Heron Werner, Patricia Mello Jungmann, Epitácio Leite Rolim Filho, Etiene Pedrosa Andrade, Roberto Souza Lemos, Alberto Borges Peixoto, Mohammad Zare Mehrjardi, Gabriele Tonni, Edward Araujo Júnior
OBJECTIVE: To determine the main neuroimaging findings of microcephalic newborns with possible Zika virus (ZIKV) intrauterine infection using transfontanellar cranial ultrasound. METHODS: We performed a retrospective study to describe the main neuroimaging in newborns with microcephaly and possible association with congenital ZIKV infection. Microcephaly was defined in the postnatal period using transfontanellar cranial examination which was performed using both two- (2D) and three-dimensional (3D) ultrasound...
September 24, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28933344/first-outbreak-of-zika-virus-in-the-continental-united-states-a-modelling-analysis
#2
Giovanni Marini, Giorgio Guzzetta, Roberto Rosà, Stefano Merler
Since 2015, Zika virus (ZIKV) has spread throughout Latin and Central America. This emerging infectious disease has been causing considerable public health concern because of severe neurological complications, especially in newborns after congenital infections. In July 2016, the first outbreak in the continental United States was identified in the Wynwood neighbourhood of Miami-Dade County, Florida. In this work, we investigated transmission dynamics using a mathematical model calibrated to observed data on mosquito abundance and symptomatic human infections...
September 14, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28916391/zika-virus-structural-biology-and-progress-in-vaccine-development
#3
REVIEW
Hsiao-Han Lin, Bak-Sau Yip, Li-Min Huang, Suh-Chin Wu
The growing number of zika virus (ZIKV) infections plus a 20-fold increase in neonatal microcephaly in newborns in Brazil have raised alarms in many countries regarding the threat to pregnant women. Instances of microcephaly and central nervous system malformations continue to increase in ZIKV outbreak regions. ZIKV is a small enveloped positive-strand RNA virus belonging to the Flavivirus genus of the Flaviviridae family. High-resolution ZIKV structures recently identified by cryo-electron microscopy indicate that the overall ZIKV structure is similar to those of other flaviviruses...
September 12, 2017: Biotechnology Advances
https://www.readbyqxmd.com/read/28878742/zika-virus-what-have-we-learnt-since-the-start-of-the-recent-epidemic
#4
REVIEW
Juan-Carlos Saiz, Miguel A Martín-Acebes, Rubén Bueno-Marí, Oscar D Salomón, Luis C Villamil-Jiménez, Jorg Heukelbach, Carlos H Alencar, Paul K Armstrong, Tania M Ortiga-Carvalho, Rosalia Mendez-Otero, Paulo H Rosado-de-Castro, Pedro M Pimentel-Coelho
Zika is a viral disease transmitted mainly by mosquitoes of the genus Aedes. In recent years, it has expanded geographically, changing from an endemic mosquito-borne disease across equatorial Asia and Africa, to an epidemic disease causing large outbreaks in several areas of the world. With the recent Zika virus (ZIKV) outbreaks in the Americas, the disease has become a focus of attention of public health agencies and of the international research community, especially due to an association with neurological disorders in adults and to the severe neurological and ophthalmological abnormalities found in fetuses and newborns of mothers exposed to ZIKV during pregnancy...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28877754/association-between-suspected-zika-virus-disease-during-pregnancy-and-giving-birth-to-a-newborn-with-congenital-microcephaly-a-matched-case-control-study
#5
Ticiane Henriques Santa Rita, Renata Barcelos Barra, Gisele Pasquali Peixoto, Pedro Goes Mesquita, Gustavo Barcelos Barra
OBJECTIVE: In early 2015, an outbreak of an acute exanthematous illness with dengue-like symptoms occurred in northeastern Brazil. By the end of the same year, an unexpected increase in the number of cases of microcephaly was observed in the region. The microcephaly outbreak cause was unknown and rumors pointing to various potential causes arose. Since we were unaware at the time if this scenario would attract the interest of the broader scientific community, due to the neglected regions associated and as often happens with many others health conditions related to infectious diseases in Latin America...
September 6, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28852261/mental-health-of-zika-virus-infected-mother-and-mother-of-newborn-with-microcephaly
#6
Viroj Wiwanitkit
No abstract text is available yet for this article.
July 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/28835502/cd8-t-cell-immune-response-in-immunocompetent-mice-during-zika-virus-infection
#7
Huarong Huang, Shihua Li, Yongli Zhang, Xiaojuan Han, Baoqian Jia, Hongtao Liu, Dandan Liu, Shuguang Tan, Qihui Wang, Yuhai Bi, William J Liu, Baidong Hou, George Fu Gao, Fuping Zhang
Zika virus (ZIKV) infection cause neurologic complications, including Guillain-Barré syndrome (GBS) in adults and central nerve system (CNS) abnormalities in fetuses. We investigated the immune response, especially CD8(+) T cell response in C57BL/6 (B6) wild type (WT) mouse during ZIKV infection. We found that robust CD8(+) T cell response was elicited, MHC-I restricted CD8(+) T cell epitopes were identified and a tetramer that recognized ZIKV specific CD8(+) T cells was developed. Finally, virus specific memory CD8(+) T cells were generated in these mice...
August 23, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28826723/zika-virus-encoded-ns2a-disrupts-mammalian-cortical-neurogenesis-by-degrading-adherens-junction-proteins
#8
Ki-Jun Yoon, Guang Song, Xuyu Qian, Jianbo Pan, Dan Xu, Hee-Sool Rho, Nam-Shik Kim, Christa Habela, Lily Zheng, Fadi Jacob, Feiran Zhang, Emily M Lee, Wei-Kai Huang, Francisca Rojas Ringeling, Caroline Vissers, Cui Li, Ling Yuan, Koeun Kang, Sunghan Kim, Junghoon Yeo, Yichen Cheng, Sheng Liu, Zhexing Wen, Cheng-Feng Qin, Qingfeng Wu, Kimberly M Christian, Hengli Tang, Peng Jin, Zhiheng Xu, Jiang Qian, Heng Zhu, Hongjun Song, Guo-Li Ming
Zika virus (ZIKV) directly infects neural progenitors and impairs their proliferation. How ZIKV interacts with the host molecular machinery to impact neurogenesis in vivo is not well understood. Here, by systematically introducing individual proteins encoded by ZIKV into the embryonic mouse cortex, we show that expression of ZIKV-NS2A, but not Dengue virus (DENV)-NS2A, leads to reduced proliferation and premature differentiation of radial glial cells and aberrant positioning of newborn neurons. Mechanistically, in vitro mapping of protein-interactomes and biochemical analysis suggest interactions between ZIKA-NS2A and multiple adherens junction complex (AJ) components...
September 7, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/28798738/zika-virus-an-emerging-worldwide-threat
#9
Irfan A Rather, Jameel B Lone, Vivek K Bajpai, Woon K Paek, Jeongheui Lim
ZIKA virus (ZIKV) poses a severe threat to the world. Recent outbreaks of ZIKV after 2007 along with its quick transmission have made this virus a matter of international concern. The virus shows symptoms that are similar to those caused in the wake of dengue virus (DENV) and other flaviviruses, which makes it difficult to discern the viral infection. Diagnosis is further complicated as the virus cross-reacts with antibodies of other viruses. Currently, molecular diagnosis of the virus is being performed by RT-PCR and IgM-captured enzyme-linked immunosorbent assay (MAC-ELISA)...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28783051/microcephaly-prevalence-in-infants-born-to-zika-virus-infected-women-a-systematic-review-and-meta-analysis
#10
REVIEW
Antonio Victor Campos Coelho, Sergio Crovella
Zika virus is an emergent flavivirus transmitted by Aedes genus mosquitoes that recently reached the Americas and was soon implicated in an increase of microcephaly incidence. The objective of the present study is to systematically review the published data and perform a meta-analysis to estimate the prevalence of microcephaly in babies born to Zika virus-infected women during pregnancy. We searched PubMed and Cochrane databases, included cohort studies, and excluded case reports and case series publications...
August 5, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28769893/imported-zika-virus-in-a-european-city-how-to-prevent-local-transmission
#11
Joan-Pau Millet, Tomàs Montalvo, Ruben Bueno-Marí, Arancha Romero-Tamarit, Albert Prats-Uribe, Lidia Fernández, Esteve Camprubí, Lucía Del Baño, Victor Peracho, Jordi Figuerola, Elena Sulleiro, Miguel J Martínez, Joan A Caylà
Background: On February 1st 2016 the WHO declared the Zika Virus (ZIKV) infection a worldwide public health emergency because of its rapid expansion and severe complications, such as Guillain-Barré Syndrome or microcephaly in newborn. The huge amount of people traveling to endemic areas and the presence of Aedes albopictus in Barcelona increase the risk of autochtonous transmission. The objective of this study was to describe the first ZIKV cases diagnosed in our city and to analyze the surveillance, prevention, and control measures implemented to avoid autochthonous transmission...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28768876/monoclonal-antibodies-against-zika-virus-therapeutics-and-their-implications-for-vaccine-design
#12
Qihui Wang, Jinghua Yan, George Fu Gao
Zika virus (ZIKV) has caused global concern due to its association with neurological complications in newborns and adults. Although no approved vaccines or antivirals against ZIKV infection to date, hundreds of monoclonal antibodies (MAbs) have been developed in a short period. Here, we first present a complete picture of the ZIKV MAbs and then focus on the neutralizing mechanisms and immune hot spot uncovered through structural studies, which provide insight for therapeutics and vaccine design.
August 2, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28736678/rapid-assessment-zika-virus-knowledge-among-clinical-specialists-in-singapore-a-cross-sectional-survey
#13
Chee F Yung, Clarence C Tam, Victor S Rajadurai, Jerry Ky Chan, Mabel Sf Low, Yong H Ng, Koh C Thoon, Lay K Tan
INTRODUCTION: We report the results of a rapid assessment of Zika virus awareness among key clinical specialties in Singapore. METHODS: Between June 6 and June 19, 2016 we conducted an online survey of doctors working in obstetrics and gynaecology, neonatology and paediatrics in Singapore. The survey included 15 multiple choice questions to measure respondents' knowledge of Zika virus in four domains covering clinical and public health. RESULTS: A total of 110 survey responses (15% response rate) were obtained, 82% of respondents worked in the public sector...
May 3, 2017: PLoS Currents
https://www.readbyqxmd.com/read/28710796/plant-produced-zika-virus-envelope-protein-elicits-neutralizing-immune-responses-that-correlate-with-protective-immunity-against-zika-virus-in-mice
#14
Ming Yang, Haiyan Sun, Huafang Lai, Jonathan Hurtado, Qiang Chen
The global Zika virus (ZIKV) outbreak and its link to foetal and newborn microcephaly and severe neurological complications in adults call for the urgent development of ZIKV vaccines. In response, we developed a subunit vaccine based on the ZIKV envelope (E) protein and investigated its immunogenicity in mice. Transient expression of ZIKV E (zE) resulted in its rapid accumulation in leaves of Nicotiana benthamiana plants. Biochemical analysis revealed that plant-produced ZIKV E (PzE) exhibited specific binding to a panel of monoclonal antibodies that recognize various zE conformational epitopes...
July 15, 2017: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/28667332/viperin-is-an-important-host-restriction-factor-in-control-of-zika-virus-infection
#15
Kylie H Van der Hoek, Nicholas S Eyre, Byron Shue, Onruedee Khantisitthiporn, Kittirat Glab-Ampi, Jillian M Carr, Matthew J Gartner, Lachlan A Jolly, Paul Q Thomas, Fatwa Adikusuma, Tanja Jankovic-Karasoulos, Claire T Roberts, Karla J Helbig, Michael R Beard
Zika virus (ZIKV) infection has emerged as a global health threat and infection of pregnant women causes intrauterine growth restriction, spontaneous abortion and microcephaly in newborns. Here we show using biologically relevant cells of neural and placental origin that following ZIKV infection, there is attenuation of the cellular innate response characterised by reduced expression of IFN-β and associated interferon stimulated genes (ISGs). One such ISG is viperin that has well documented antiviral activity against a wide range of viruses...
June 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28662753/animal-models-of-zika-virus
#16
Michael P Bradley, Claude M Nagamine
Zika virus has garnered great attention over the last several years, as outbreaks of the disease have emerged throughout the Western Hemisphere. Until quite recently Zika virus was considered a fairly benign virus, with limited clinical severity in both people and animals. The size and scope of the outbreak in the Western Hemisphere has allowed for the identification of severe clinical disease that is associated with Zika virus infection, most notably microcephaly among newborns, and an association with Guillian-Barré syndrome in adults...
June 1, 2017: Comparative Medicine
https://www.readbyqxmd.com/read/28650987/accuracy-of-zika-virus-disease-case-definition-during-simultaneous-dengue-and-chikungunya-epidemics
#17
José Ueleres Braga, Clarisse Bressan, Ana Paula Razal Dalvi, Guilherme Amaral Calvet, Regina Paiva Daumas, Nadia Rodrigues, Mayumi Wakimoto, Rita Maria Ribeiro Nogueira, Karin Nielsen-Saines, Carlos Brito, Ana Maria Bispo de Filippis, Patrícia Brasil
BACKGROUND: Zika is a new disease in the American continent and its surveillance is of utmost importance, especially because of its ability to cause neurological manifestations as Guillain-Barré syndrome and serious congenital malformations through vertical transmission. The detection of suspected cases by the surveillance system depends on the case definition adopted. As the laboratory diagnosis of Zika infection still relies on the use of expensive and complex molecular techniques with low sensitivity due to a narrow window of detection, most suspected cases are not confirmed by laboratory tests, mainly reserved for pregnant women and newborns...
2017: PloS One
https://www.readbyqxmd.com/read/28646619/early-insights-into-zika-s-microcephaly-physiopathology-from-the-epicenter-of-the-outbreak-teratogenic-apoptosis-in-the-central-nervous-system
#18
Patricia Jungmann, Pedro Pires, Edward Araujo Júnior
Fetal infection by the Zika virus has been implicated in the exceptional rise in the number of microcephalic newborns recorded by the end of 2015 in Brazil. The mechanism by which this teratogenic effect is produced in the developing brain has not been fully established. Very early in the outbreak, we addressed this question by evaluating available initial data from a gestational and postnatal clinical investigation in the Brazilian state of Pernambuco. The present study was undertaken to test the hypothesis that the subtractive dysmorphic brain malformations observed in Zika-related microcephaly are primarily due to the massive induction of apoptosis of neuroprogenitor cells...
September 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28623165/ocular-effects-of-zika-virus-a-review
#19
REVIEW
Maria Carolina Marquezan, Camila V Ventura, Jeanne S Sheffield, William Christopher Golden, Revaz Omiadze, Rubens Belfort, William May
Zika virus was considered an innocent pathogen while restricted to the African and Asian population; however, after reaching the Americas in March 2015, it became a global threat. Despite usually causing mild or no symptoms in infected adults, Zika virus displays a different behavior toward fetuses. When infected during gestation, fetuses have their immature neural cells killed by the virus and consequently have devastating findings at birth. In the past year the drastic effects of Zika virus infection in newborns include neurological, ophthalmological, audiological, and skeletal abnormalities...
June 13, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28622059/author-s-reply-zika-virus-infection-and-ophthalmic-examination-in-newborn
#20
Hnin Hnin Oo, Praveen Kumar Balne, Rupesh Agrawal
No abstract text is available yet for this article.
June 16, 2017: Ocular Immunology and Inflammation
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