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https://www.readbyqxmd.com/read/29767504/motion-based-immunological-detection-of-zika-virus-using-pt-nanomotors-and-a-cellphone
#1
Mohamed Shehata Draz, Nivethitha Kota Lakshminaraasimulu, Sanchana Krishnakumar, Dheerendranath Battalapalli, Anish Vasan, Manoj Kumar Kanakasabapathy, Aparna Sreeram, Shantanu Kallakuri, Prudhvi Thirumalaraju, Yudong Li, Stephane Hua, Xu G Yu, Daniel R Kuritzkes, Hadi Shafiee
Zika virus (ZIKV) infection is an emerging pandemic threat to humans that can be fatal in newborns. Advances in digital health systems and nanoparticles can facilitate the development of sensitive and portable detection technologies for timely management of emerging viral infections. Here we report a nanomotor-based bead-motion cellphone (NBC) system for the immunological detection of ZIKV. The presence of virus in a testing sample results in the accumulation of platinum (Pt)-nanomotors on the surface of beads, causing their motion in H2 O2 solution...
May 16, 2018: ACS Nano
https://www.readbyqxmd.com/read/29668332/neurological-complications-of-zika-virus-infection
#2
Francisco Javier Carod-Artal
Zika virus (ZIKV) disease is a vector-borne infectious disease transmitted by Aedes mosquitoes. Recently, ZIKV has caused outbreaks in most American countries. Areas covered: Publications about neurological complications of ZIKV infection retrieved from pubmed searchers were reviewed, and reference lists and relevant articles from review articles were also examined. Vertical/intrauterine transmission leads to congenital infection and causes microcephaly and congenital ZIKV syndrome. ZIKV preferentially infects human neural progenitor cells and triggers cell apoptosis...
May 2018: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/29615760/human-sertoli-cells-support-high-levels-of-zika-virus-replication-and-persistence
#3
Anil Kumar, Juan Jovel, Joaquin Lopez-Orozco, Daniel Limonta, Adriana M Airo, Shangmei Hou, Iryna Stryapunina, Chad Fibke, Ronald B Moore, Tom C Hobman
Zika virus is a teratogenic mosquito-transmitted flavivirus that is associated with birth defects in newborns and Guillain-Barré syndrome in adults. The virus can also be sexually transmitted, but currently, very little is known about the cell types supporting virus replication and persistence in human testes. Using primary cell cultures, we observed that Sertoli but not Leydig cells are highly susceptible to Zika virus infection, a process that is dependent on the TAM family receptor Axl. In cell culture, Sertoli cells could be productively infected with Zika virus for at least 6-weeks...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29615676/silent-infection-of-human-dendritic-cells-by-african-and-asian-strains-of-zika-virus
#4
Nathalie J Vielle, Beatrice Zumkehr, Obdulio García-Nicolás, Fabian Blank, Miloš Stojanov, Didier Musso, David Baud, Artur Summerfield, Marco P Alves
While Zika virus (ZIKV) circulated for decades (African lineage strains) without report of outbreaks and severe complications, its emergence in French Polynesia and subsequently in the Americas (Asian lineage strains) was associated with description of severe neurological defects in newborns/neonates and adults. With the aim to identify virus lineage-dependent factors, we compared cell susceptibility, virus replication, cell death and innate immune responses following infection with two African and three contemporary Asian lineage strains of ZIKV...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29600283/zika-virus-infection-preferentially-counterbalances-human-peripheral-monocyte-and-or-nk-cell-activity
#5
Fok-Moon Lum, David Lee, Tze-Kwang Chua, Jeslin J L Tan, Cheryl Y P Lee, Xuan Liu, Yongxiang Fang, Bernett Lee, Wearn-Xin Yee, Natasha Y Rickett, Po-Ying Chia, Vanessa Lim, Yee-Sin Leo, David A Matthews, Julian A Hiscox, Lisa F P Ng
Zika virus (ZIKV) has reemerged in the population and caused unprecedented global outbreaks. Here, the transcriptomic consequences of ZIKV infection were studied systematically first in human peripheral blood CD14+ monocytes and monocyte-derived macrophages with high-density RNA sequencing. Analyses of the ZIKV genome revealed that the virus underwent genetic diversification, and differential mRNA abundance was found in host cells during infection. Notably, there was a significant change in the cellular response, with cross talk between monocytes and natural killer (NK) cells as one of the highly identified pathways...
March 2018: MSphere
https://www.readbyqxmd.com/read/29593941/dynamics-of-zika-virus-outbreaks-an-overview-of-mathematical-modeling-approaches
#6
Anuwat Wiratsudakul, Parinya Suparit, Charin Modchang
Background: The Zika virus was first discovered in 1947. It was neglected until a major outbreak occurred on Yap Island, Micronesia, in 2007. Teratogenic effects resulting in microcephaly in newborn infants is the greatest public health threat. In 2016, the Zika virus epidemic was declared as a Public Health Emergency of International Concern (PHEIC). Consequently, mathematical models were constructed to explicitly elucidate related transmission dynamics. Survey Methodology: In this review article, two steps of journal article searching were performed...
2018: PeerJ
https://www.readbyqxmd.com/read/29593256/microencephaly-in-fetal-piglets-following-in-utero-inoculation-of-zika-virus
#7
P J Wichgers Schreur, L van Keulen, D Anjema, J Kant, J Kortekaas
Zika virus (ZIKV) is a mosquito-borne flavivirus that became associated with microcephaly in newborns and Guillain-Barré syndrome in adults after its emergence in the Pacific and the Americas in 2015. Newly developed rodent and nonhuman primate models have already revealed important insights into ZIKV-induced neuropathology. Nonhuman primates are phylogenetically closely related to humans and are therefore preferred human surrogates in ZIKV research. However, the use of nonhuman primates, particularly during gestation, raises ethical issues...
March 29, 2018: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29579059/cardiac-findings-in-infants-with-in-utero-exposure-to-zika-virus-a-cross-sectional-study
#8
Dulce H G Orofino, Sonia R L Passos, Raquel V C de Oliveira, Carla Verona B Farias, Maria de Fatima M P Leite, Sheila M Pone, Marcos V da S Pone, Helena A R Teixeira Mendes, Maria Elizabeth L Moreira, Karin Nielsen-Saines
BACKGROUND: Antenatal exposure to Zika virus (ZIKV) is related to severe neurological manifestations. A previous study in Brazil reported an increased incidence of non-severe congenital heart defects in infants with diagnosis of congenital Zika syndrome but without laboratory confirmation of ZIKV infection in the mother or infant. The objective of this study is to report echocardiographic (ECHO) findings in infants with laboratory confirmed antenatal exposure to ZIKV. METHODOLOGY: Cross sectional study of cardiologic assessments of infants born between November 2015 and January 2017 with confirmed vertical exposure to ZIKV in Rio de Janeiro, Brazil...
March 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29574335/infection-by-zika-viruses-requires-the-transmembrane-protein-axl-endocytosis-and-low-ph
#9
Mirjana Persaud, Alicia Martinez-Lopez, Cindy Buffone, Steven A Porcelli, Felipe Diaz-Griffero
The recent Zika virus (ZIKV) outbreak in Brazil has suggested associations of this virus infection with neurological disorders, including microcephaly in newborn infants and Guillian-Barré syndrome in adults. Previous reports have shown that AXL, a transmembrane receptor tyrosine kinase protein, is essential for ZIKV infection of mammalian cells, but this remains controversial. Here, we have assessed the involvement of AXL in the ability of ZIKV to infect mammalian cells, and also the requirement for endocytosis and acidic pH...
March 22, 2018: Virology
https://www.readbyqxmd.com/read/29561936/microcephaly-caused-by-congenital-zika-virus-infection-and-viral-detection-in-maternal-urine-during-pregnancy
#10
Vanessa Couras Regadas, Márcio de Castro E Silva, Lucas Giansante Abud, Luiz Mario Pereira Lopes Labadessa, Rafael Gouvêa Gomes de Oliveira, Cecília Hissae Miyake, Rodolfo Mendes Queiroz
Currently Latin America is undergoing a major epidemic of Zika virus, which is transmitted by Aedes mosquitoes. Concern for Zika virus infection has been increasing as it is suspected of causing brain defects in newborns such as microcephaly and, more recently, potential neurological and autoimmune complications including Guillian-Barré syndrome and acute disseminated encephalomyelitis. We describe a case of virus infection in a 25-year-old woman during the first trimester of her pregnancy, confirmed by laboratory tests only for the detection of viral particles in maternal urine, with imaging studies demonstrating the progression of cranial and encephalic changes in the fetus and later in the newborn, such as head circumference reduction, cerebral calcifications and ventriculomegaly...
January 2018: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/29543803/development-and-evaluation-of-a-novel-high-throughput-image-based-fluorescent-neutralization-test-for-detection-of-zika-virus-infection
#11
Andrea Cristine Koishi, Andréia Akemi Suzukawa, Camila Zanluca, Daria Elena Camacho, Guillermo Comach, Claudia Nunes Duarte Dos Santos
Zika virus (ZIKV) is an emerging arbovirus belonging to the genus flavivirus that comprises other important public health viruses, such as dengue (DENV) and yellow fever (YFV). In general, ZIKV infection is a self-limiting disease, however cases of Guillain-Barré syndrome and congenital brain abnormalities in newborn infants have been reported. Diagnosing ZIKV infection remains a challenge, as viral RNA detection is only applicable until a few days after the onset of symptoms. After that, serological tests must be applied, and, as expected, high cross-reactivity between ZIKV and other flavivirus serology is observed...
March 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29541942/recent-advances-in-animal-models-of-zika-virus-infection
#12
Shupeng Dong, Qiming Liang
An infection by Zika virus (ZIKV), a mosquito-borne flavivirus, broke out in South American regions in 2015, and recently showed a tendency of spreading to North America and even worldwide. ZIKV was first detected in 1947 and only 14 human infection cases were reported until 2007. This virus was previously observed to cause only mild flu-like symptoms. However, recent ZIKV infections might be responsible for the increasing cases of neurological disorders such as Guillain-Barré syndrome and congenital defects, including newborn microcephaly...
March 14, 2018: Virologica Sinica
https://www.readbyqxmd.com/read/29518067/update-noncongenital-zika-virus-disease-cases-50-u-s-states-and-the-district-of-columbia-2016
#13
Victoria Hall, William L Walker, Nicole P Lindsey, Jennifer A Lehman, Jonathan Kolsin, Kimberly Landry, Ingrid B Rabe, Susan L Hills, Marc Fischer, J Erin Staples, Carolyn V Gould, Stacey W Martin
Zika virus is a flavivirus primarily transmitted to humans by Aedes aegypti mosquitoes (1). Zika virus infections also have been documented through intrauterine transmission resulting in congenital infection; intrapartum transmission from a viremic mother to her newborn; sexual transmission; blood transfusion; and laboratory exposure (1-3). Most Zika virus infections are asymptomatic or result in mild clinical illness, characterized by acute onset of fever, maculopapular rash, arthralgia, or nonpurulent conjunctivitis; Guillain-Barré syndrome, meningoencephalitis, and severe thrombocytopenia rarely have been associated with Zika virus infection (1)...
March 9, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29503261/zika-virus-and-pregnancy-in-brazil-what-happened
#14
Alessandra Mendelski Pereira, Denise Leite Maia Monteiro, Heron Werner, Pedro Daltro, Tatiana Fazecas, Bianca Guedes, Gabriele Tonni, Alberto Borges Peixoto, Edward Araujo Júnior
The recent epidemic of Zika virus (ZIKV) infection in Central and South America is one of the most serious global public health emergencies since the Ebola outbreak in West Africa. In Brazil, especially in the north, northeast, and southeast parts of the country, the ZIKV outbreak is a cause of concern for pregnant women because ZIKV intrauterine infection has been found to be associated with multiple brain malformations and microcephaly. In Brazil, the number of newborns with confirmed microcephaly per year recorded during the ZIKV outbreak, has been approximately 15 times greater than previously reported...
March 1, 2018: Journal of the Turkish German Gynecological Association
https://www.readbyqxmd.com/read/29481868/an-overview-of-mosquito-vectors-of-zika-virus
#15
Sébastien Boyer, Elodie Calvez, Thais Chouin-Carneiro, Diawo Diallo, Anna-Bella Failloux
The mosquito-borne arbovirus Zika virus (ZIKV, Flavivirus, Flaviviridae), has caused an outbreak impressive by its magnitude and rapid spread. First detected in Uganda in Africa in 1947, from where it spread to Asia in the 1960s, it emerged in 2007 on the Yap Island in Micronesia and hit most islands in the Pacific region in 2013. Subsequently, ZIKV was detected in the Caribbean, and Central and South America in 2015, and reached North America in 2016. Although ZIKV infections are in general asymptomatic or causing mild self-limiting illness, severe symptoms have been described including neurological disorders and microcephaly in newborns...
March 2, 2018: Microbes and Infection
https://www.readbyqxmd.com/read/29472998/vector-competence-of-selected-north-american-anopheles-and-culex-mosquitoes-for-zika-virus
#16
Brittany L Dodson, Sujit Pujhari, Jason L Rasgon
Zika virus (ZIKV) is a vector-borne flavivirus that has caused recent outbreaks associated with serious disease in infants and newborns in the Americas. Aedes mosquitoes are the primary vectors for ZIKV, but little is known about the diversity of mosquitoes that can transmit ZIKV in North America. We chose three abundant North American mosquito species ( Anopheles freeborni , Anopheles quadrimaculatus , and Culex tarsalis ) and one known vector species ( Aedes aegypti ), fed them blood meals supplemented with a recent outbreak ZIKV strain, and tested bodies, legs, and saliva for infectious ZIKV...
2018: PeerJ
https://www.readbyqxmd.com/read/29472902/prevention-and-control-strategies-to-counter-zika-virus-a-special-focus-on-intervention-approaches-against-vector-mosquitoes-current-updates
#17
REVIEW
Raj K Singh, Kuldeep Dhama, Rekha Khandia, Ashok Munjal, Kumaragurubaran Karthik, Ruchi Tiwari, Sandip Chakraborty, Yashpal S Malik, Rubén Bueno-Marí
Zika virus (ZIKV) is the most recent intruder that acquired the status of global threat creating panic and frightening situation to public owing to its rapid spread, attaining higher virulence and causing complex clinical manifestations including microcephaly in newborns and Guillain Barré Syndrome. Alike other flaviviruses, the principal mode of ZIKV transmission is by mosquitoes. Advances in research have provided reliable diagnostics for detecting ZIKV infection, while several drug/therapeutic targets and vaccine candidates have been identified recently...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29453985/zika-virus-infected-primary-microglia-impairs-npcs-proliferation-and-differentiation
#18
Jin Wang, Jing Liu, Rui Zhou, Xin Ding, Qipeng Zhang, Chenyu Zhang, Liang Li
Zika virus (ZIKV) can lead to severe birth defects especially microcephaly in newborns by infecting human neural progenitors and impairing brain development. However, as the resident immune cells in the brain, the role of microglia in the ZIKV pathology is not clearly defined. To understand the interplay between immune response and neural cells, we investigate the interaction between microglia and NPCs during ZIKV infection. Our results demonstrate that primary microglia infected with ZIKV induces an inflammatory response similar to that in human, producing high level of tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), interleukin 1β (IL-1β) and inducible nitric oxide synthase (iNOS)...
March 4, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29437048/development-of-infants-with-congenital-zika-syndrome-what-do-we-know-and-what-can-we-expect
#19
Anne C Wheeler
The association between Zika virus infection during pregnancy and severe birth defects in infants has led to worldwide attention focused on the mechanisms of the disease and the prevention of future exposure. Surveillance efforts around the world continue with the goal of identifying and monitoring all potentially exposed women and their newborns. For infants who were born with congenital Zika syndrome (CZS) and their families, an uncertain future awaits. As infants who were born with CZS during the most recent outbreak enter their second year of life, new developments in the outcomes of the condition continue to unfold, providing some insight into the likely long-term sequalae...
February 2018: Pediatrics
https://www.readbyqxmd.com/read/29423037/the-structure-of-the-binary-methyltransferase-sah-complex-from-zika-virus-reveals-a-novel-conformation-for-the-mechanism-of-mrna-capping
#20
Chatrin Chatrin, Sandeep K Talapatra, Bruno Canard, Frank Kozielski
Zika virus, a flavivirus like Dengue and West Nile viruses, poses a significant risk as a pathogen in the category of emerging infectious diseases. Zika infections typically cause nonspecific, mild symptoms, but can also manifest as a neurological disorder like Guillain-Barré syndrome. Infection in pregnant women is linked to microcephaly in newborn infants. The methyltransferase domain of the non-structural protein 5 is responsible for two sequential methylations of the 5'-RNA cap. This is crucial for genome stability, efficient translation, and escape from the host immune response...
January 9, 2018: Oncotarget
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