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dce perfusion and brain tumors

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https://www.readbyqxmd.com/read/29441225/assessment-of-the-agreement-between-cerebral-hemodynamic-indices-quantified-using-dynamic-susceptibility-contrast-and-dynamic-contrast-enhanced-perfusion-magnetic-resonance-imagings
#1
Seyed Salman Zakariaee, Mohammad Ali Oghabian, Kavous Firouznia, Guive Sharifi, Farshid Arbabi, Farhad Samiei
Background: Brain tumor is one of the most common tumors. A successful treatment might be achieved with an early identification. Pathological investigation as the gold standard method for tumor identification has some limitations. Noninvasive assessment of tumor specifications may be possible using perfusion-weighted magnetic resonance imaging (MRI). Cerebral blood volume (CBV) and cerebral blood flow (CBF) could be calculated based on dynamic contrast-enhanced MRI (DCE-MRI) in addition to dynamic susceptibility contrast MRI (DSC-MRI) modality...
2018: Journal of Clinical Imaging Science
https://www.readbyqxmd.com/read/29361245/brain-gliomas-multicenter-standardized-assessment-of-dynamic-contrast-enhanced-and-dynamic-susceptibility-contrast-mr-images
#2
Nicoletta Anzalone, Antonella Castellano, Marcello Cadioli, Gian Marco Conte, Valeria Cuccarini, Alberto Bizzi, Marco Grimaldi, Antonella Costa, Giovanni Grillea, Paolo Vitali, Domenico Aquino, Maria Rosa Terreni, Valter Torri, Bradley J Erickson, Massimo Caulo
Purpose To evaluate the feasibility of a standardized protocol for acquisition and analysis of dynamic contrast material-enhanced (DCE) and dynamic susceptibility contrast (DSC) magnetic resonance (MR) imaging in a multicenter clinical setting and to verify its accuracy in predicting glioma grade according to the new World Health Organization 2016 classification. Materials and Methods The local research ethics committees of all centers approved the study, and informed consent was obtained from patients. One hundred patients with glioma were prospectively examined at 3...
January 22, 2018: Radiology
https://www.readbyqxmd.com/read/29197390/evaluation-of-b-1-inhomogeneity-effect-on-dce-mri-data-analysis-of-brain-tumor-patients-at-3t
#3
Anirban Sengupta, Rakesh Kumar Gupta, Anup Singh
BACKGROUND: Dynamic-contrast-enhanced (DCE) MRI data acquired using gradient echo based sequences is affected by errors in flip angle (FA) due to transmit B1 inhomogeneity (B1 inh). The purpose of the study was to evaluate the effect of B1 inh on quantitative analysis of DCE-MRI data of human brain tumor patients and to evaluate the clinical significance of B1 inh correction of perfusion parameters (PPs) on tumor grading. METHODS: An MRI study was conducted on 35 glioma patients at 3T...
December 2, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29097933/clinical-applications-of-contrast-enhanced-perfusion-mri-techniques-in-gliomas-recent-advances-and-current-challenges
#4
REVIEW
Junfeng Zhang, Heng Liu, Haipeng Tong, Sumei Wang, Yizeng Yang, Gang Liu, Weiguo Zhang
Gliomas possess complex and heterogeneous vasculatures with abnormal hemodynamics. Despite considerable advances in diagnostic and therapeutic techniques for improving tumor management and patient care in recent years, the prognosis of malignant gliomas remains dismal. Perfusion-weighted magnetic resonance imaging techniques that could noninvasively provide superior information on vascular functionality have attracted much attention for evaluating brain tumors. However, nonconsensus imaging protocols and postprocessing analysis among different institutions impede their integration into standard-of-care imaging in clinic...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/28851989/delineation-of-tumor-habitats-based-on-dynamic-contrast-enhanced-mri
#5
Yu-Cherng Channing Chang, Ellen Ackerstaff, Yohann Tschudi, Bryan Jimenez, Warren Foltz, Carl Fisher, Lothar Lilge, HyungJoon Cho, Sean Carlin, Robert J Gillies, Yoganand Balagurunathan, Raphael L Yechieli, Ty Subhawong, Baris Turkbey, Alan Pollack, Radka Stoyanova
Tumor heterogeneity can be elucidated by mapping subregions of the lesion with differential imaging characteristics, called habitats. Dynamic Contrast Enhanced (DCE-)MRI can depict the tumor microenvironments by identifying areas with variable perfusion and vascular permeability, since individual tumor habitats vary in the rate and magnitude of the contrast uptake and washout. Of particular interest is identifying areas of hypoxia, characterized by inadequate perfusion and hyper-permeable vasculature. An automatic procedure for delineation of tumor habitats from DCE-MRI was developed as a two-part process involving: (1) statistical testing in order to determine the number of the underlying habitats; and (2) an unsupervised pattern recognition technique to recover the temporal contrast patterns and locations of the associated habitats...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28669014/temporal-evolution-of-perfusion-parameters-in-brain-metastases-treated-with-stereotactic-radiosurgery-comparison-of-intravoxel-incoherent-motion-and-dynamic-contrast-enhanced-mri
#6
Anish Kapadia, Hatef Mehrabian, John Conklin, Sean P Symons, Pejman J Maralani, Greg J Stanisz, Arjun Sahgal, Hany Soliman, Chinthaka C Heyn
Intravoxel incoherent motion (IVIM) is a magnetic resonance imaging (MRI) technique that is seeing increasing use in neuro-oncology and offers an alternative to contrast-enhanced perfusion techniques for evaluation of tumor blood volume after stereotactic radiosurgery (SRS). To date, IVIM has not been validated against contrast enhanced techniques for brain metastases after SRS. In the present study, we measure blood volume for 20 brain metastases (15 patients) at baseline, 1 week and 1 month after SRS using IVIM and dynamic contrast enhanced (DCE)-MRI...
October 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28623038/perfusion-kinetics-in-human-brain-tumor-with-dce-mri-derived-model-and-cfd-analysis
#7
A Bhandari, A Bansal, A Singh, N Sinha
Cancer is one of the leading causes of death all over the world. Among the strategies that are used for cancer treatment, the effectiveness of chemotherapy is often hindered by factors such as irregular and non-uniform uptake of drugs inside tumor. Thus, accurate prediction of drug transport and deposition inside tumor is crucial for increasing the effectiveness of chemotherapeutic treatment. In this study, a computational model of human brain tumor is developed that incorporates dynamic contrast enhanced-magnetic resonance imaging (DCE-MRI) data into a voxelized porous media model...
July 5, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28556691/t1-weighted-dynamic-contrast-enhanced-brain-magnetic-resonance-imaging-a-preliminary-study-with-low-infusion-rate-in-pediatric-patients
#8
Bruno-Bernard Rochetams, Bénédicte Marechal, Jean-Philippe Cottier, Kathleen Gaillot, Catherine Sembely-Taveau, Dominique Sirinelli, Baptiste Morel
Background The aim of this preliminary study is to evaluate the results of T1-weighted dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) in pediatric patients at 1.5T, with a low peripheral intravenous gadoteric acid injection rate of 1 ml/s. Materials and methods Children with neurological symptoms were examined prospectively with conventional MRI and T1-weighted DCE MRI. An magnetic resonance perfusion analysis method was used to obtain time-concentration curves (persistent pattern, type-I; plateau pattern, type-II; washout pattern, type-III) and to calculate pharmacokinetic parameters...
October 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/28488024/glioma-grading-and-determination-of-idh-mutation-status-and-atrx-loss-by-dce-and-asl-perfusion
#9
Cornelia Brendle, Johann-Martin Hempel, Jens Schittenhelm, Marco Skardelly, Ghazaleh Tabatabai, Benjamin Bender, Ulrike Ernemann, Uwe Klose
PURPOSE: To evaluate arterial spin labeling (ASL) perfusion and dynamic contrast-enhanced (DCE) perfusion in glioma grading according to the previous WHO classification of 2007, as well as concerning isocitrate dehydrogenase (IDH) mutation status and ATRX expression as required by the new WHO 2016 brain tumor classification. METHODS: The mean values of Ktrans, Kep, Ve, and Vp by DCE perfusion, and cerebral blood flow (CBF) by ASL perfusion were assessed retrospectively in 40 patients with initial glioma diagnosis...
May 9, 2017: Clinical Neuroradiology
https://www.readbyqxmd.com/read/28303695/dynamic-contrast-enhanced-mri-perfusion-for-differentiating-between-melanoma-and-lung-cancer-brain-metastases
#10
Vaios Hatzoglou, Jamie Tisnado, Alpesh Mehta, Kyung K Peck, Mariza Daras, Antonio M Omuro, Kathryn Beal, Andrei I Holodny
Brain metastases originating from different primary sites overlap in appearance and are difficult to differentiate with conventional MRI. Dynamic contrast-enhanced (DCE)-MRI can assess tumor microvasculature and has demonstrated utility in characterizing primary brain tumors. Our aim was to evaluate the performance of plasma volume (Vp) and volume transfer coefficient (Ktrans ) derived from DCE-MRI in distinguishing between melanoma and nonsmall cell lung cancer (NSCLC) brain metastases. Forty-seven NSCLC and 23 melanoma brain metastases were retrospectively assessed with DCE-MRI...
April 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28149758/defining-the-endpoints-how-to-measure-the-efficacy-of-drugs-that-are-active-against-central-nervous-system-metastases
#11
REVIEW
Alessandra Fabi, Antonello Vidiri
Brain metastases (BMs) are the most common cause of malignant central nervous system (CNS) tumors in adults. In the recent past, patients with BMs were excluded from clinical trials, but now, with the advent of new biological and immunological drugs, their inclusion is more common. In the last era response and progression criteria used across clinical trials have defined the importance to consider not only measurement changes of brain lesions but also the modification of parameters related to the metastases such as metabolism of tissue and its pathological features...
December 2016: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/28090589/spiral-perfusion-imaging-with-consecutive-echoes-spice%C3%A2-for-the-simultaneous-mapping-of-dsc-and-dce-mri-parameters-in-brain-tumor-patients-theory-and-initial-feasibility
#12
Eric S Paulson, Douglas E Prah, Kathleen M Schmainda
Dynamic contrast-enhanced (DCE) and dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI) are the perfusion imaging techniques most frequently used to probe the angiogenic character of brain neoplasms. With these methods, T1- and T2/T2*-weighted imaging sequences are used to image the distribution of gadolinium (Gd)-based contrast agents. However, it is well known that Gd exhibits combined T1, T2, and T2* shortening effects in tissue, and therefore, the results of both DCE- and DSC-MRI can be confounded by these opposing effects...
December 2016: Tomography: a Journal for Imaging Research
https://www.readbyqxmd.com/read/27731907/brain-capillary-transit-time-heterogeneity-in-healthy-volunteers-measured-by-dynamic-contrast-enhanced-t1-weighted-perfusion-mri
#13
Henrik B W Larsson, Mark B Vestergaard, Ulrich Lindberg, Helle K Iversen, Stig P Cramer
PURPOSE: Capillary transit time heterogeneity, measured as CTH, may set the upper limit for extraction of substances in brain tissue, e.g., oxygen. The purpose of this study was to investigate the feasibility of dynamic contrast-enhanced T1 weighted MRI (DCE-MRI) at 3 Tesla (T), in estimating CTH based on a gamma-variate model of the capillary transit time distribution. In addition, we wanted to investigate if a subtle increase of the blood-brain barrier permeability can be incorporated into the model, still allowing estimation of CTH...
June 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27576699/demonstration-of-dce-mri-as-an-early-pharmacodynamic-biomarker-of-response-to-vegf-trap-in-glioblastoma
#14
Allison F O'Neill, Lei Qin, Patrick Y Wen, John F de Groot, Annick D Van den Abbeele, Jeffrey T Yap
Glioblastoma (GBM) is an incurable brain tumor characterized by the expression of pro-angiogenic cytokines. A recent phase II clinical trial studied VEGF Trap in adult patients with temozolomide-resistant GBM. We sought to explore changes in [18 F]Fluorodeoxyglucose positron emission tomography (FDG-PET) or magnetic resonance imaging (MRI) in trial participants correlating these changes with disease response. FDG-PET and MRI images obtained before and after the first dose of VEGF Trap were spatially co-registered...
December 2016: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/27383624/optimization-of-two-compartment-exchange-model-analysis-for-dynamic-contrast-enhanced-mri-incorporating-bolus-arrival-time
#15
Guy Nadav, Gilad Liberman, Moran Artzi, Nahum Kiryati, Dafna Ben Bashat
PURPOSE: To optimize the analysis of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) under the two-compartment-exchange-model (2CXM) and to incorporate voxelwise bolus-arrival-time (BAT). MATERIALS AND METHODS: The accuracy of the pharmacokinetic (PK) parameters, extracted from 3T DCE-MRI using 2CXM, was tested under several conditions: eight algorithms for data estimation; correction for BAT; using model selection; different temporal resolution and scan duration...
January 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/26688076/a-prospective-trial-of-dynamic-contrast-enhanced-mri-perfusion-and-fluorine-18-fdg-pet-ct-in-differentiating-brain-tumor-progression-from-radiation-injury-after-cranial-irradiation
#16
Vaios Hatzoglou, T Jonathan Yang, Antonio Omuro, Igor Gavrilovic, Gary Ulaner, Jennifer Rubel, Taylor Schneider, Kaitlin M Woo, Zhigang Zhang, Kyung K Peck, Kathryn Beal, Robert J Young
BACKGROUND: The aim of this study was to assess the effectiveness of fluorine-18 fluorodeoxyglucose (FDG) PET-CT and dynamic contrast-enhanced (DCE) MRI in differentiating tumor progression and radiation injury in patients with indeterminate enhancing lesions after radiation therapy (RT) for brain malignancies. METHODS: Patients with indeterminate enhancing brain lesions on conventional MRI after RT underwent brain DCE-MRI and PET-CT in a prospective trial. Informed consent was obtained...
June 2016: Neuro-oncology
https://www.readbyqxmd.com/read/26404120/dynamic-glucose-enhanced-dge-mri-for-combined-imaging-of-blood-brain-barrier-break-down-and-increased-blood-volume-in-brain-cancer
#17
Xiang Xu, Kannie W Y Chan, Linda Knutsson, Dmitri Artemov, Jiadi Xu, Guanshu Liu, Yoshinori Kato, Bachchu Lal, John Laterra, Michael T McMahon, Peter C M van Zijl
PURPOSE: Recently, natural d-glucose was suggested as a potential biodegradable contrast agent. The feasibility of using d-glucose for dynamic perfusion imaging was explored to detect malignant brain tumors based on blood brain barrier breakdown. METHODS: Mice were inoculated orthotopically with human U87-EGFRvIII glioma cells. Time-resolved glucose signal changes were detected using chemical exchange saturation transfer (glucoCEST) MRI. Dynamic glucose enhanced (DGE) MRI was used to measure tissue response to an intravenous bolus of d-glucose...
December 2015: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/26235208/comparison-of-glioblastomas-and-brain-metastases-using-dynamic-contrast-enhanced-perfusion-mri
#18
COMPARATIVE STUDY
Brian C Jung, Julio Arevalo-Perez, John K Lyo, Andrei I Holodny, Sasan Karimi, Robert J Young, Kyung K Peck
PURPOSE: To compare glioblastoma and brain metastases using T1-weighted dynamic contrast-enhanced (DCE)-MRI perfusion technique. METHODS: 26 patients with glioblastoma and 32 patients with metastatic brain lesions with no treatment who underwent DCE-MRI were, retrospectively, analyzed. DCE perfusion parameters K(trans) and Vp were calculated for the whole tumor. Signal intensity time curves were quantified by calculating the area under the curve (AUC) and the logarithmic slope of the washout phase to explore the heterogeneous tumor characteristics...
March 2016: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/26203926/early-changes-in-perfusion-of-glioblastoma-during-radio-and-chemotherapy-evaluated-by-t1-dynamic-contrast-enhanced-magnetic-resonance-imaging
#19
Søren Møller, Michael Lundemann, Ian Law, Hans S Poulsen, Henrik B W Larsson, Svend Aage Engelholm
BACKGROUND: The survival times of patients with glioblastoma differ widely and biomarkers that would enable individualized treatment are needed. The objective of this study was to measure changes in the vascular physiology of tumor using T1-dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) in patients with glioblastoma during early stages of radio- and chemotherapy (Tx) and explore possible correlations with treatment outcomes. MATERIAL AND METHODS: An exploratory prospective study was planned...
2015: Acta Oncologica
https://www.readbyqxmd.com/read/25880892/assessment-of-vessel-permeability-by-combining-dynamic-contrast-enhanced-and-arterial-spin-labeling-mri
#20
Ho-Ling Liu, Ting-Ting Chang, Feng-Xian Yan, Cheng-He Li, Yu-Shi Lin, Alex M Wong
The forward volumetric transfer constant (K(trans)), a physiological parameter extracted from dynamic contrast-enhanced (DCE) MRI, is weighted by vessel permeability and tissue blood flow. The permeability × surface area product per unit mass of tissue (PS) in brain tumors was estimated in this study by combining the blood flow obtained through pseudo-continuous arterial spin labeling (PCASL) and K(trans) obtained through DCE MRI. An analytical analysis and a numerical simulation were conducted to understand how errors in the flow and K(trans) estimates would propagate to the resulting PS...
June 2015: NMR in Biomedicine
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