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dce perfusion and brain tumors

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https://www.readbyqxmd.com/read/27731907/brain-capillary-transit-time-heterogeneity-in-healthy-volunteers-measured-by-dynamic-contrast-enhanced-t1-weighted-perfusion-mri
#1
Henrik B W Larsson, Mark B Vestergaard, Ulrich Lindberg, Helle K Iversen, Stig P Cramer
PURPOSE: Capillary transit time heterogeneity, measured as CTH, may set the upper limit for extraction of substances in brain tissue, e.g., oxygen. The purpose of this study was to investigate the feasibility of dynamic contrast-enhanced T1 weighted MRI (DCE-MRI) at 3 Tesla (T), in estimating CTH based on a gamma-variate model of the capillary transit time distribution. In addition, we wanted to investigate if a subtle increase of the blood-brain barrier permeability can be incorporated into the model, still allowing estimation of CTH...
October 12, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27576699/demonstration-of-dce-mri-as-an-early-pharmacodynamic-biomarker-of-response-to-vegf-trap-in-glioblastoma
#2
Allison F O'Neill, Lei Qin, Patrick Y Wen, John F de Groot, Annick D Van den Abbeele, Jeffrey T Yap
Glioblastoma (GBM) is an incurable brain tumor characterized by the expression of pro-angiogenic cytokines. A recent phase II clinical trial studied VEGF Trap in adult patients with temozolomide-resistant GBM. We sought to explore changes in [(18)F]Fluorodeoxyglucose positron emission tomography (FDG-PET) or magnetic resonance imaging (MRI) in trial participants correlating these changes with disease response. FDG-PET and MRI images obtained before and after the first dose of VEGF Trap were spatially co-registered...
August 30, 2016: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/27383624/optimization-of-two-compartment-exchange-model-analysis-for-dynamic-contrast-enhanced-mri-incorporating-bolus-arrival-time
#3
Guy Nadav, Gilad Liberman, Moran Artzi, Nahum Kiryati, Dafna Ben Bashat
PURPOSE: To optimize the analysis of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) under the two-compartment-exchange-model (2CXM) and to incorporate voxelwise bolus-arrival-time (BAT). MATERIALS AND METHODS: The accuracy of the pharmacokinetic (PK) parameters, extracted from 3T DCE-MRI using 2CXM, was tested under several conditions: eight algorithms for data estimation; correction for BAT; using model selection; different temporal resolution and scan duration...
July 7, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/26688076/a-prospective-trial-of-dynamic-contrast-enhanced-mri-perfusion-and-fluorine-18-fdg-pet-ct-in-differentiating-brain-tumor-progression-from-radiation-injury-after-cranial-irradiation
#4
Vaios Hatzoglou, T Jonathan Yang, Antonio Omuro, Igor Gavrilovic, Gary Ulaner, Jennifer Rubel, Taylor Schneider, Kaitlin M Woo, Zhigang Zhang, Kyung K Peck, Kathryn Beal, Robert J Young
BACKGROUND: The aim of this study was to assess the effectiveness of fluorine-18 fluorodeoxyglucose (FDG) PET-CT and dynamic contrast-enhanced (DCE) MRI in differentiating tumor progression and radiation injury in patients with indeterminate enhancing lesions after radiation therapy (RT) for brain malignancies. METHODS: Patients with indeterminate enhancing brain lesions on conventional MRI after RT underwent brain DCE-MRI and PET-CT in a prospective trial. Informed consent was obtained...
June 2016: Neuro-oncology
https://www.readbyqxmd.com/read/26404120/dynamic-glucose-enhanced-dge-mri-for-combined-imaging-of-blood-brain-barrier-break-down-and-increased-blood-volume-in-brain-cancer
#5
Xiang Xu, Kannie W Y Chan, Linda Knutsson, Dmitri Artemov, Jiadi Xu, Guanshu Liu, Yoshinori Kato, Bachchu Lal, John Laterra, Michael T McMahon, Peter C M van Zijl
PURPOSE: Recently, natural d-glucose was suggested as a potential biodegradable contrast agent. The feasibility of using d-glucose for dynamic perfusion imaging was explored to detect malignant brain tumors based on blood brain barrier breakdown. METHODS: Mice were inoculated orthotopically with human U87-EGFRvIII glioma cells. Time-resolved glucose signal changes were detected using chemical exchange saturation transfer (glucoCEST) MRI. Dynamic glucose enhanced (DGE) MRI was used to measure tissue response to an intravenous bolus of d-glucose...
December 2015: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/26235208/comparison-of-glioblastomas-and-brain-metastases-using-dynamic-contrast-enhanced-perfusion-mri
#6
Brian C Jung, Julio Arevalo-Perez, John K Lyo, Andrei I Holodny, Sasan Karimi, Robert J Young, Kyung K Peck
PURPOSE: To compare glioblastoma and brain metastases using T1-weighted dynamic contrast-enhanced (DCE)-MRI perfusion technique. METHODS: 26 patients with glioblastoma and 32 patients with metastatic brain lesions with no treatment who underwent DCE-MRI were, retrospectively, analyzed. DCE perfusion parameters K(trans) and Vp were calculated for the whole tumor. Signal intensity time curves were quantified by calculating the area under the curve (AUC) and the logarithmic slope of the washout phase to explore the heterogeneous tumor characteristics...
March 2016: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/26203926/early-changes-in-perfusion-of-glioblastoma-during-radio-and-chemotherapy-evaluated-by-t1-dynamic-contrast-enhanced-magnetic-resonance-imaging
#7
Søren Møller, Michael Lundemann, Ian Law, Hans S Poulsen, Henrik B W Larsson, Svend Aage Engelholm
BACKGROUND: The survival times of patients with glioblastoma differ widely and biomarkers that would enable individualized treatment are needed. The objective of this study was to measure changes in the vascular physiology of tumor using T1-dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) in patients with glioblastoma during early stages of radio- and chemotherapy (Tx) and explore possible correlations with treatment outcomes. MATERIAL AND METHODS: An exploratory prospective study was planned...
2015: Acta Oncologica
https://www.readbyqxmd.com/read/25880892/assessment-of-vessel-permeability-by-combining-dynamic-contrast-enhanced-and-arterial-spin-labeling-mri
#8
Ho-Ling Liu, Ting-Ting Chang, Feng-Xian Yan, Cheng-He Li, Yu-Shi Lin, Alex M Wong
The forward volumetric transfer constant (K(trans)), a physiological parameter extracted from dynamic contrast-enhanced (DCE) MRI, is weighted by vessel permeability and tissue blood flow. The permeability × surface area product per unit mass of tissue (PS) in brain tumors was estimated in this study by combining the blood flow obtained through pseudo-continuous arterial spin labeling (PCASL) and K(trans) obtained through DCE MRI. An analytical analysis and a numerical simulation were conducted to understand how errors in the flow and K(trans) estimates would propagate to the resulting PS...
June 2015: NMR in Biomedicine
https://www.readbyqxmd.com/read/25845813/differentiation-of-solitary-brain-metastasis-from-glioblastoma-multiforme-a-predictive-multiparametric-approach-using-combined-mr-diffusion-and-perfusion
#9
Adam Herman Bauer, William Erly, Franklin G Moser, Marcel Maya, Kambiz Nael
INTRODUCTION: Solitary brain metastasis (MET) and glioblastoma multiforme (GBM) can appear similar on conventional MRI. The purpose of this study was to identify magnetic resonance (MR) perfusion and diffusion-weighted biomarkers that can differentiate MET from GBM. METHODS: In this retrospective study, patients were included if they met the following criteria: underwent resection of a solitary enhancing brain tumor and had preoperative 3.0 T MRI encompassing diffusion tensor imaging (DTI), dynamic contrast-enhanced (DCE), and dynamic susceptibility contrast (DSC) perfusion...
July 2015: Neuroradiology
https://www.readbyqxmd.com/read/25793147/diagnosis-of-brain-tumors-using-dynamic-contrast-enhanced-perfusion-imaging-with-a-short-acquisition-time
#10
Takashi Abe, Yoshifumi Mizobuchi, Kohei Nakajima, Yoichi Otomi, Saho Irahara, Yuki Obama, Mungunkhuyag Majigsuren, Delgerdalai Khashbat, Teruyoshi Kageji, Shinji Nagahiro, Masafumi Harada
This study sought to determine the diagnostic utility of perfusion parameters derived from dynamic contrast-enhanced (DCE) perfusion MRI with a short acquisition time (approximately 3.5 min) in patients with glioma, brain metastasis, and primary CNS lymphoma (PCNSL). Twenty-six patients with 29 lesions (4 low-grade glioma, 13 high-grade glioma, 7 metastasis, and 5 PCNSL) underwent DCE-MRI in a 3 T scanner. A ROI was placed on the hotspot of each tumor in maps for volume transfer contrast K (trans) , extravascular extracellular volume V e , and fractional plasma volume V p ...
2015: SpringerPlus
https://www.readbyqxmd.com/read/25592446/which-is-the-best-advanced-mr-imaging-protocol-for-predicting-recurrent-metastatic-brain-tumor-following-gamma-knife-radiosurgery-focused-on-perfusion-method
#11
Myeong Ju Koh, Ho Sung Kim, Choong Gon Choi, Sang Joon Kim
INTRODUCTION: High spatial resolution of dynamic contrast-enhanced (DCE) MR imaging allows characterization of heterogenous tumor microenvironment. Our purpose was to determine which is the best advanced MR imaging protocol, focused on additional MR perfusion method, for predicting recurrent metastatic brain tumor following gamma-knife radiosurgery (GKRS). METHODS: Seventy-two consecutive patients with post-GKRS metastatic brain tumor were enrolled. Two readers independently calculated the percentile histogram cutoffs for normalized cerebral blood volume (nCBV) from dynamic susceptibility contrast (DSC) imaging and initial area under the time signal-intensity curve (IAUC) from DCE imaging, respectively...
April 2015: Neuroradiology
https://www.readbyqxmd.com/read/25480677/radiation-protection-issues-in-dynamic-contrast-enhanced-perfusion-computed-tomography
#12
REVIEW
Gunnar Brix, Ursula Lechel, Elke Nekolla, Jürgen Griebel, Christoph Becker
Dynamic contrast-enhanced (DCE) CT studies are increasingly used in both medical care and clinical trials to improve diagnosis and therapy management of the most common life-threatening diseases: stroke, coronary artery disease and cancer. It is thus the aim of this review to briefly summarize the current knowledge on deterministic and stochastic radiation effects relevant for patient protection, to present the essential concepts for determining radiation doses and risks associated with DCE-CT studies as well as representative results, and to discuss relevant aspects to be considered in the process of justification and optimization of these studies...
December 2015: European Journal of Radiology
https://www.readbyqxmd.com/read/25446606/automated-voxel-based-analysis-of-volumetric-dynamic-contrast-enhanced-ct-data-improves-measurement-of-serial-changes-in-tumor-vascular-biomarkers
#13
COMPARATIVE STUDY
Catherine Coolens, Brandon Driscoll, Caroline Chung, Tina Shek, Alborz Gorjizadeh, Cynthia Ménard, David Jaffray
OBJECTIVES: Development of perfusion imaging as a biomarker requires more robust methodologies for quantification of tumor physiology that allow assessment of volumetric tumor heterogeneity over time. This study proposes a parametric method for automatically analyzing perfused tissue from volumetric dynamic contrast-enhanced (DCE) computed tomography (CT) scans and assesses whether this 4-dimensional (4D) DCE approach is more robust and accurate than conventional, region-of-interest (ROI)-based CT methods in quantifying tumor perfusion with preliminary evaluation in metastatic brain cancer...
January 1, 2015: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/25370705/classification-of-tumor-area-using-combined-dce-and-dsc-mri-in-patients-with-glioblastoma
#14
Moran Artzi, Deborah T Blumenthal, Felix Bokstein, Guy Nadav, Gilad Liberman, Orna Aizenstein, Dafna Ben Bashat
This study proposes an automatic method for identification and quantification of different tissue components: the non-enhanced infiltrative tumor, vasogenic edema and enhanced tumor areas, at the subject level, in patients with glioblastoma (GB) based on dynamic contrast enhancement (DCE) and dynamic susceptibility contrast (DSC) MRI. Nineteen MR data sets, obtained from 12 patients with GB, were included. Seven patients were scanned before and 8 weeks following bevacizumab initiation. Segmentation of the tumor area was performed based on the temporal data of DCE and DSC at the group-level using k-means algorithm, and further at the subject-level using support vector machines algorithm...
January 2015: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/25170392/intraoperative-perfusion-magnetic-resonance-imaging-cutting-edge-improvement-in-neurosurgical-procedures
#15
REVIEW
Stephan Ulmer
The goal in brain tumor surgery is to remove the maximum achievable amount of the tumor, preventing damage to "eloquent" brain regions as the amount of brain tumor resection is one of the prognostic factors for time to tumor progression and median survival. To achieve this goal, a variety of technical advances have been introduced, including an operating microscope in the late 1950s, computer-assisted devices for surgical navigation and more recently, intraoperative imaging to incorporate and correct for brain shift during the resection of the lesion...
August 28, 2014: World Journal of Radiology
https://www.readbyqxmd.com/read/25088433/correlative-assessment-of-tumor-microcirculation-using-contrast-enhanced-perfusion-mri-and-intravoxel-incoherent-motion-diffusion-weighted-mri-is-there-a-link-between-them
#16
COMPARATIVE STUDY
Sotirios Bisdas, Christian Braun, Marco Skardelly, Jens Schittenhelm, Tze Hern Teo, Choon Hua Thng, Uwe Klose, Tong San Koh
The purpose of this study was to correlate intravoxel incoherent motion (IVIM) imaging with classical perfusion-weighted MRI metrics in human gliomas. Parametric images for slow diffusion coefficient (D), fast diffusion coefficient (D*), and fractional perfusion-related volume (f) in patients with high-grade gliomas were generated. Maps of Fp (plasma flow), vp (vascular plasma volume), PS (permeability surface-area product), ve (extravascular, extracellular volume), E (extraction ratio), ke (influx ratio into the interstitium), and tc (vascular transit time) from dynamic contrast-enhanced (DCE) and dynamic susceptibility contrast-enhanced (DSC) MRI were also generated...
October 2014: NMR in Biomedicine
https://www.readbyqxmd.com/read/24916487/effect-of-acute-hyperglycemia-on-moderately-hypothermic-gl261-mouse-glioma-monitored-by-t1-weighted-dce-mri
#17
Rui V Simões, Juan E Ortuño, Louisa Bokacheva, Ana P Candiota, Maria J Ledesma-Carbayo, Teresa Delgado-Goñi, Maria L García-Martín, Andrés Santos, Carles Arús
OBJECTIVE: We sought to evaluate the effects of acute hyperglycemia induced by intraperitoneal injection of glucose (2.7 g/kg) on vascular delivery to GL261 mouse gliomas kept at moderate hypothermia (~30 °C). MATERIALS AND METHODS: Seven GL261 glioma-bearing mice were studied by T1-weighted DCE MRI before and after an injection of glucose (n = 4) or saline (n = 3). Maximum relative contrast enhancement (RCE) and initial area under the enhancement curve (IAUC) were determined in each pixel...
April 2015: Magma
https://www.readbyqxmd.com/read/24759636/mri-biomarkers-identify-the-differential-response-of-glioblastoma-multiforme-to-anti-angiogenic-therapy
#18
Shahrzad Jalali, Caroline Chung, Warren Foltz, Kelly Burrell, Sanjay Singh, Richard Hill, Gelareh Zadeh
BACKGROUND: Although anti-angiogenic therapy (AATx) holds great promise for treatment of malignant gliomas, its therapeutic efficacy is not well understood and can potentially increase the aggressive recurrence of gliomas. It is essential to establish sensitive, noninvasive biomarkers that can detect failure of AATx and tumor recurrence early so that timely adaptive therapy can be instituted. We investigated the efficacy of MRI biomarkers that can detect response to different classes of AATxs used alone or in combination with radiation...
June 2014: Neuro-oncology
https://www.readbyqxmd.com/read/24376814/cilengitide-induced-temporal-variations-in-transvascular-transfer-parameters-of-tumor-vasculature-in-a-rat-glioma-model-identifying-potential-mri-biomarkers-of-acute-effects
#19
Tavarekere N Nagaraja, Madhava P Aryal, Stephen L Brown, Hassan Bagher-Ebadian, Tom Mikkelsen, James J Yang, Swayamprava Panda, Kelly A Keenan, Glauber Cabral, James R Ewing
Increased efficacy of radiotherapy (RT) 4-8 h after Cilengitide treatment has been reported. We hypothesized that the effects of Cilengitide on tumor transvascular transfer parameters might underlie, and thus predict, this potentiation. Athymic rats with orthotopic U251 glioma were studied at ~21 days after implantation using dynamic contrast-enhanced (DCE)-MRI. Vascular parameters, viz: plasma volume fraction (v(p)), forward volume transfer constant (K(trans)) and interstitial volume fraction (v(e)) of a contrast agent, were determined in tumor vasculature once before, and again in cohorts 2, 4, 8, 12 and 24 h after Cilengitide administration (4 mg/kg; N = 31; 6-7 per cohort)...
2013: PloS One
https://www.readbyqxmd.com/read/23798369/noninvasive-tumor-hypoxia-measurement-using-magnetic-resonance-imaging-in-murine-u87-glioma-xenografts-and-in-patients-with-glioblastoma
#20
Inna V Linnik, Marietta L J Scott, Katherine F Holliday, Neil Woodhouse, John C Waterton, James P B O'Connor, Hervé Barjat, Carsten Liess, Jose Ulloa, Helen Young, Caroline Dive, Cassandra L Hodgkinson, Tim Ward, Darren Roberts, Samantha J Mills, Gerard Thompson, Giovanni A Buonaccorsi, Susan Cheung, Alan Jackson, Josephine H Naish, Geoff J M Parker
PURPOSE: There is a clinical need for noninvasive, nonionizing imaging biomarkers of tumor hypoxia and oxygenation. We evaluated the relationship of T1 -weighted oxygen-enhanced magnetic resonance imaging (OE-MRI) measurements to histopathology measurements of tumor hypoxia in a murine glioma xenograft and demonstrated technique translation in human glioblastoma multiforme. METHODS: Preclinical evaluation was performed in a subcutaneous murine human glioma xenograft (U87MG)...
May 2014: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
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