Xue-Min Yin, Yi-Yi Song, Wen-Yi Jiang, Hao-Tian Zhang, Jing-Wei Chen, Koji Murao, Meng-Xiao Han, Wan-Ping Sun, Guo-Xing Zhang
BACKGROUND AND AIM: The present study aimed to investigate whether the mitochondrial KATP channel contributes to angiotensin II (Ang II)-induced vascular dysfunction, the development of hypertension, and atherosclerosis. METHODS AND RESULTS: ApoE (-/-) mice fed a high-fat diet were chronically infused with Ang II for eight weeks and concomitantly treated with losartan (ARB), apocynin, or 5-hydroxy decanoate (5-HD), or 3-methyladenine (3-MA). Systolic blood pressure was measured, and pathological changes of aortic or liver tissue were observed...
January 26, 2024: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD