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https://www.readbyqxmd.com/read/28510609/spr-based-fragment-screening-with-neurotensin-receptor-1-generates-novel-small-molecule-ligands
#1
Sylwia Huber, Fabio Casagrande, Melanie N Hug, Lisha Wang, Philipp Heine, Lutz Kummer, Andreas Plückthun, Michael Hennig
The neurotensin receptor 1 represents an important drug target involved in various diseases of the central nervous system. So far, the full exploitation of potential therapeutic activities has been compromised by the lack of compounds with favorable physicochemical and pharmacokinetic properties which efficiently penetrate the blood-brain barrier. Recent progress in the generation of stabilized variants of solubilized neurotensin receptor 1 and its subsequent purification and successful structure determination presents a solid starting point to apply the approach of fragment-based screening to extend the chemical space of known neurotensin receptor 1 ligands...
2017: PloS One
https://www.readbyqxmd.com/read/28466845/genetic-variation-and-rna-structure-regulate-microrna-biogenesis
#2
Noemi Fernandez, Ross A Cordiner, Robert S Young, Nele Hug, Sara Macias, Javier F Cáceres
MiRNA biogenesis is highly regulated at the post-transcriptional level; however, the role of sequence and secondary RNA structure in this process has not been extensively studied. A single G to A substitution present in the terminal loop of pri-mir-30c-1 in breast and gastric cancer patients had been previously described to result in increased levels of mature miRNA. Here, we report that this genetic variant directly affects Drosha-mediated processing of pri-mir-30c-1 in vitro and in cultured cells. Structural analysis of this variant revealed an altered RNA structure that facilitates the interaction with SRSF3, an SR protein family member that promotes pri-miRNA processing...
May 3, 2017: Nature Communications
https://www.readbyqxmd.com/read/28441485/new-insights-into-the-reaction-paths-of-4-carboxybenzophenone-triplet-with-oligopeptides-containing-n-and-c-terminal-methionine-residues
#3
Piotr Filipiak, Krzysztof Bobrowski, Gordon L Hug, Dariusz Pogocki, Christian Schöneich, Bronislaw Marciniak
The oxidation processes of l-Met-(Pro)n-l-Met peptides that contain two Met residues located on the N and C termini and separated by a defined number (n = 0-4) of proline residues were investigated in aqueous solutions using laser flash photolysis. The use of such peptides allowed for distance control between the sulfur atoms located in the side chains of the Met residues. Interactions between side chains of the Met residues were probed by the observation of transients with σ*-type 2c-3e (S∴S)(+), (S∴N)(+), and (S∴O)(+) bonds as well as of α-(alkylthio)alkyl radicals (αS)...
May 11, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28437762/public-attitudes-toward-depression-and-help-seeking-impact-of-the-ospi-europe-depression-awareness-campaign-in-four-european-regions
#4
Elisabeth Kohls, Evelien Coppens, Juliane Hug, Eline Wittevrongel, Chantal Van Audenhove, Nicole Koburger, Ella Arensman, András Székely, Ricardo Gusmão, Ulrich Hegerl
BACKGROUND: Public attitudes toward depression and help-seeking behaviour are important factors influencing depressed people to obtain professional help and adequate treatment. OSPI-Europe is a multi-level suicide prevention programme including a public awareness campaign. It was implemented in four regions of four European countries (Germany, Hungary, Ireland and Portugal). This paper reports the results of the evaluation of the campaign, including its visibility and effects of the campaign on stigma associated with depression and help-seeking behaviour...
April 8, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28435124/action-recognition-is-viewpoint-dependent-in-the-visual-periphery
#5
Laura Fademrecht, Isabelle Bülthoff, Stephan de la Rosa
Recognizing actions of others across the whole visual field is required for social interactions. In a previous study, we have shown that recognition is very good even when life-size avatars who were facing the observer carried out actions (e.g. waving) and were presented very far away from the fovea (Fademrecht, Bülthoff, & de la Rosa, 2016). We explored the possibility whether this remarkable performance was owed to life-size avatars facing the observer, which - according to some social cognitive theories (e...
April 26, 2017: Vision Research
https://www.readbyqxmd.com/read/28422222/electron-transfer-in-silicon-bridged-adjacent-chromophores-the-source-for-blue-green-emission
#6
Malgorzata Bayda, Gonzalo Angulo, Gordon L Hug, Monika Ludwiczak, Jerzy Karolczak, Jacek Koput, Jacek Dobkowski, Bronislaw Marciniak
Si-Bridged chromophores have been proposed as sources for blue-green emission in several technological applications. The origin of this dual emission is to be found in an internal charge transfer reaction. The current work is an attempt to describe the details of these processes in these kinds of substances, and to design a molecular architecture to improve their performance. Nuclear motions essential for intramolecular charge transfer (ICT) can involve processes from twisted internal moieties to dielectric relaxation of the solvent...
April 19, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28421565/iron-homeostasis-in-inflammation-a-single-centre-prospective-observational-study-in-medical-inpatients
#7
Carl Chrobak, Jan Adam Sidler, Alix O'Meara, Sabine Schaedelin, Balthasar L Hug
AIMS OF THE STUDY: We aimed to assess a potential association of iron status with mortality and morbidity of inpatients with systemic inflammation. METHODS: This was a single centre prospective observational study. From April 2014 to October 2014, all consecutive medical inpatients aged >=18 years with a C-reactive protein value >5 mg/l on hospital admission were eligible for the study. We excluded pregnant women and patients with terminal renal insufficiency or past allogeneic stem cell transplantation...
April 19, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28418537/assessment-of-decellularization-of-heart-bioimplants-using-a-raman-spectroscopy-method
#8
Elena V Timchenko, Pavel E Timchenko, Artur Lichtenberg, Alexander Assmann, Hug Aubin, Payam Akhyari, Larisa T Volova, Svetlana V Pershutkina
No abstract text is available yet for this article.
September 1, 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28414786/the-model-for-end-stage-liver-disease-meld-as-a-predictor-of-short-term-mortality-in-staphylococcus-aureus-bloodstream-infection-a-single-centre-observational-study
#9
Jan A Roth, Andreas F Widmer, Sarah Tschudin-Sutter, Marc Dangel, Reno Frei, Manuel Battegay, Balthasar L Hug
BACKGROUND: Automated laboratory-based prediction models may support clinical decisions in Staphylococcus aureus bloodstream infections (BSIs), which carry a particularly high mortality. Small studies indicated that the laboratory-based Model for End-stage Liver Disease (MELD) score is a risk factor for mortality in critically ill patients with infections. For S. aureus BSIs, we therefore aimed to assess a potential association of the MELD score with mortality. METHODS: In this single-centre observational study, all consecutive patients with a first episode of methicillin-susceptible S...
2017: PloS One
https://www.readbyqxmd.com/read/28412047/patient-reported-quality-of-life-after-proton-beam-therapy-for-prostate-cancer-the-effect-of%C3%A2-prostate-size
#10
Anuj Goenka, Neil B Newman, Hiral Fontanilla, Oren Cahlon, Brian Chon, Henry Tsai, Eugen Hug, Carl Brown, Carlos Vargas, Rahul R Parikh
BACKGROUND: In the present study, we assessed the effect of prostate gland size on patient-assessed genitourinary and gastrointestinal (GI) quality of life (QOL) after definitive treatment of prostate adenocarcinoma with proton beam therapy. PATIENTS AND METHODS: As a part of a prospective outcome tracking protocol, 81 patients treated at a single center between with proton beam therapy completed the Expanded Prostate Cancer Index Composite (EPIC) questionnaire before treatment and at the follow-up examinations...
March 18, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28407305/female-striated-urogenital-sphincter-contraction-measured-by-shear-wave-elastography-during-pelvic-floor-muscle-activation-proof-of-concept-and-validation
#11
Rafeef Aljuraifani, Ryan E Stafford, François Hug, Paul W Hodges
AIMS: Investigation of the function of the striated urogenital sphincter (SUS) is challenging because it is difficult to access and requires invasive measures. Ultrasound shear wave elastography (SWE) is a non-invasive real-time technique used to estimate tissue stiffness. As muscle stiffness can be used as an estimate of muscle force, SWE provides an opportunity to study contraction of the peri-urethral musculature. Validation of SWE to study SUS during functional tasks, such as pelvic floor muscle contractions, is required prior to application in clinical populations...
April 13, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28404759/paving-the-way-for-dose-banding-of-chemotherapy-an-analytical-approach
#12
Heike Reinhardt, Rainer Trittler, Alison G Eggleton, Stefan Wöhrl, Thomas Epting, Marion Buck, Sabine Kaiser, Daniel Jonas, Justus Duyster, Manfred Jung, Martin J Hug, Monika Engelhardt
Background: In an interdepartmental cooperation, we investigated the feasibility and benefits of implementing dose banding of chemotherapy at our medical center. Based on this concept, chemotherapy doses are clustered into bands of similar dosage levels, thereby allowing the preproduction of frequently used standard doses of drugs, with sufficient physicochemical stability. Although established practice in the United Kingdom, there is little published evidence of its introduction elsewhere. Methods: We performed an analysis of local prescribing practice (22,310 chemotherapies) and identified gemcitabine, 5-fluorouracil, and carboplatin, among various others, as cytotoxic drugs suitable for dose banding...
April 2017: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/28388407/chromatin-architecture-emerges-during-zygotic-genome-activation-independent-of-transcription
#13
Clemens B Hug, Alexis G Grimaldi, Kai Kruse, Juan M Vaquerizas
Chromatin architecture is fundamental in regulating gene expression. To investigate when spatial genome organization is first established during development, we examined chromatin conformation during Drosophila embryogenesis and observed the emergence of chromatin architecture within a tight time window that coincides with the onset of transcription activation in the zygote. Prior to zygotic genome activation, the genome is mostly unstructured. Early expressed genes serve as nucleation sites for topologically associating domain (TAD) boundaries...
April 6, 2017: Cell
https://www.readbyqxmd.com/read/28388402/can-we-just-say-transcription-second
#14
Peter Hugo Lodewijk Krijger, Wouter de Laat
The striking correlation between genome topology and transcriptional activity has for decades made researchers revisit the question, "Does form follow function, or does function follow form?" In a new study, Hug et al. address this question by comparing the timing of zygotic genome activation to the emergence of genome structures during Drosophila embryogenesis.
April 6, 2017: Cell
https://www.readbyqxmd.com/read/28379244/biofilm-composition-in-the-olt-river-romania-reservoirs-impacted-by-a-chlor-alkali-production-plant
#15
P Dranguet, C Cosio, S Le Faucheur, D Hug Peter, J-L Loizeau, V-Gh Ungureanu, V I Slaveykova
Freshwater biofilms can be useful indicators of water quality and offer the possibility to assess contaminant effects at the community level. The present field study examines the effects of chlor-alkali plant effluents on the community composition of biofilms grown in the Olt River (Romania) reservoirs. The relationship between ambient water quality variables and community composition alterations was explored. Amplicon sequencing revealed a significant modification of the composition of microalgal, bacterial and fungal communities in the biofilms collected in the impacted reservoirs in comparison with those living in the uncontaminated control reservoir...
April 5, 2017: Environmental Science. Processes & Impacts
https://www.readbyqxmd.com/read/28377998/intra-abdominal-migration-of-a-k-wire-during-revision-total-hip-arthroplasty
#16
Kevin T Hug, Navin D Fernando
Revision total hip arthroplasty in the setting of severe acetabular bone loss is a challenging problem that is becoming more common. Kirschner wires are often used during acetabular revision for temporary fixation of trial components. We describe an intraoperative migration of a Kirschner wire through the acetabulum into the peritoneal cavity, requiring acute laparoscopic removal.
March 2017: Arthroplasty Today
https://www.readbyqxmd.com/read/28344564/investigating-the-grammatical-and-pragmatic-origins-of-wh-questions-in-children-with-autism-spectrum-disorders
#17
Manya Jyotishi, Deborah Fein, Letitia Naigles
Compared to typically developing children, children with autism (ASD) show delayed production of wh-questions. It is currently controversial the degree to which such deficits derive from social-pragmatic requirements and/or because these are complex grammatical structures. The current study employed the intermodal preferential looking (IPL) paradigm, which reduces social-pragmatic demands. The IPL paradigm can help distinguish these proposals, as successful comprehension promotes the "pragmatics-origins" argument whereas comprehension difficulties would implicate a "grammatical-origins" argument...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28325767/cohesive-properties-of-the-caulobacter-crescentus-holdfast-adhesin-are-regulated-by-a-novel-c-di-gmp-effector-protein
#18
Kathrin S Sprecher, Isabelle Hug, Jutta Nesper, Eva Potthoff, Mohamed-Ali Mahi, Matteo Sangermani, Volkhard Kaever, Torsten Schwede, Julia Vorholt, Urs Jenal
When encountering surfaces, many bacteria produce adhesins to facilitate their initial attachment and to irreversibly glue themselves to the solid substrate. A central molecule regulating the processes of this motile-sessile transition is the second messenger c-di-GMP, which stimulates the production of a variety of exopolysaccharide adhesins in different bacterial model organisms. In Caulobacter crescentus, c-di-GMP regulates the synthesis of the polar holdfast adhesin during the cell cycle, yet the molecular and cellular details of this control are currently unknown...
March 21, 2017: MBio
https://www.readbyqxmd.com/read/28320545/haloperidol-undermining-gastroparesis-symptoms-hugs-in-the-emergency-department
#19
Rene Ramirez, Philip Stalcup, Brandon Croft, Michael A Darracq
BACKGROUND: Gastroparesis associated nausea, vomiting & abdominal pain (GP N/V/AP) are common presentations to the emergency department (ED). Treatment is often limited to antiemetic, prokinetic, opioid, & nonopioid agents. Haloperidol (HP) has been shown to have analgesic & antiemetic properties. We sought to evaluate HP in the ED as an alternative treatment of GP N/V/AP. METHODS: Using an electronic medical record, 52 patients who presented to the ED w/GP N/V/AP secondary to diabetes mellitus and were treated w/HP were identified...
March 12, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28320476/developing-and-evaluating-rare-disease-educational-materials-co-created-by-expert-clinicians-and-patients-the-paradigm-of-congenital-hypogonadotropic-hypogonadism
#20
Corin Badiu, Marco Bonomi, Ivan Borshchevsky, Martine Cools, Margarita Craen, Cristina Ghervan, Michael Hauschild, Eli Hershkovitz, Erik Hrabovszky, Anders Juul, Soo-Hyun Kim, Phillip Kumanov, Beatriz Lecumberri, Manuel C Lemos, Vassos Neocleous, Marek Niedziela, Sandra Pekic Djurdjevic, Luca Persani, Franziska Phan-Hug, Duarte Pignatelli, Nelly Pitteloud, Vera Popovic, Richard Quinton, Nicos Skordis, Neil Smith, Magdalena Avbelj Stefanija, Cheng Xu, Jacques Young, Andrew A Dwyer
BACKGROUND: Patients with rare diseases face health disparities and are often challenged to find accurate information about their condition. We aimed to use the best available evidence and community partnerships to produce patient education materials for congenital hypogonadotropic hypogonadism (CHH) and the olfacto-genital (Kallmann) syndrome (i.e., CHH and defective sense of smell), and to evaluate end-user acceptability. Expert clinicians, researchers and patients co-created the materials in a multi-step process...
March 20, 2017: Orphanet Journal of Rare Diseases
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