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https://www.readbyqxmd.com/read/29766945/proposed-solution-for-dorsal-internal-carotid-artery-aneurysms-suggestion-of-a-novel-new-clip-design
#1
Ashish Aggarwal, Manarshhjot Singh, Parveen Kalra
Dorsal internal carotid artery (ICA) aneurysms are notorious for their high morbidity and mortality. They have an extremely fragile wall and have a high chance of rupture and clip slippage during the intraoperative and postoperative period. Strategies proposed to mitigate these problems encompass including part of the normal ICA wall in addition to neck of aneurysm in clip blades, as well as the use of encircling materials (silicon, cellulose, Weck's clip) over a clip. The Achilles' heel of the problem is to take an appropriate thickness of the normal ICA in clip blades...
May 2018: Neurology India
https://www.readbyqxmd.com/read/29762270/preference-based-glaucoma-specific-health-related-quality-of-life-instrument-development-of-the-health-utility-for-glaucoma
#2
Sergei Muratov, Dominik W Podbielski, Kevin Kennedy, Susan M Jack, Julia Pemberton, Iqbal Ike K Ahmed, Monika Baltaziak, Feng Xie
PURPOSE: To develop a descriptive system for a glaucoma-specific preference-based health-related quality of life (HRQoL) instrument: the Health Utility for Glaucoma (HUG-5). METHODS: The descriptive system was developed in two stages: item identification and item selection. A systematic literature review of HRQoL assessment of glaucoma was conducted using a comprehensive search strategy. Purposeful sampling was used to recruit patients with different clinical characteristics...
May 12, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29758578/-cf-lung-disease-a-german-s3-guideline-module-2-diagnostics-and-treatment-in-chronic-infection-with-pseudomonas-aeruginosa
#3
C Schwarz, B Schulte-Hubbert, J Bend, M Abele-Horn, I Baumann, W Bremer, F Brunsmann, D Dieninghoff, O Eickmeier, H Ellemunter, R Fischer, J Grosse-Onnebrink, J Hammermann, H Hebestreit, M Hogardt, C Hügel, M Hug, S Illing, A Jung, B Kahl, A Koitschev, R Mahlberg, J G Mainz, F Mattner, A Mehl, A Möller, C Muche-Borowski, T Nüßlein, M Puderbach, S Renner, E Rietschel, F C Ringshausen, S Schmidt, L Sedlacek, H Sitter, C Smaczny, B Tümmler, R Vonberg, M O Wielpütz, H Wilkens, B Wollschläger, J Zerlik, U Düesberg, S van Koningsbruggen-Rietschel
Cystic Fibrosis (CF) is the most common autosomal-recessive genetic disease affecting approximately 8000 people in Germany. The disease is caused by mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene leading to dysfunction of CFTR, a transmembrane chloride channel. This defect causes insufficient hydration of the epithelial lining fluid which leads to chronic inflammation of the airways. Recurrent infections of the airways as well as pulmonary exacerbations aggravate chronic inflammation, lead to pulmonary fibrosis and tissue destruction up to global respiratory insufficiency, which is responsible for the mortality in over 90 % of patients...
May 2018: Pneumologie
https://www.readbyqxmd.com/read/29752910/describing-functioning-in-people-living-with-spinal-cord-injury-in-switzerland-a-graphical-modelling-approach
#4
Cristina Ehrmann, Birgit Prodinger, Hans Peter Gmünder, Kerstin Hug, Jerome E Bickenbach, Gerold Stucki
OBJECTIVE: To describe functioning in people living with spinal cord injury (SCI) in Switzerland. DESIGN: Secondary analysis of cross-sectional survey data. SETTING: Community, Switzerland. PARTICIPANTS: Individuals (N=1549) who were 16 years or older with a history of traumatic or non-traumatic SCI and have a permanent residence in Switzerland. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Functioning was operationalized through four domains: impairments in body functions (measured with the SCI Secondary Conditions Scale); mental functions (Mental Health sub-scale of the SF-36); independence in performing activities (SCI Independence Measure Self-Report); performance problems in participation (Utrecht Scale for Evaluation Rehabilitation-Participation)...
May 9, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29735541/multiplex-quantification-identifies-novel-exercise-regulated-myokines-cytokines-in-plasma-and-in-glycolytic-and-oxidative-skeletal-muscle
#5
Hannah Little, Stefanie Y Tan, Francesca Cali, Susana Rodriguez, Xia Lei, Andrew Wolfe, Christopher Hug, G William Wong
Exercise is known to confer major health benefits, but the underlying mechanisms are not well understood. The systemic effects of exercise on multi-organ systems are thought to be partly due to myokines/cytokines secreted by skeletal muscle. The extent to which exercise alters cytokine expression and secretion in different muscle fiber types has not been systematically examined.  Here, we assessed changes in 66 mouse cytokines in serum, and in glycolytic (plantaris) and oxidative (soleus) muscles, in response to sprint, endurance, or chronic wheel running...
May 7, 2018: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/29728684/tissue-thin-lasers-flex-to-hug-curves
#6
(no author information available yet)
No abstract text is available yet for this article.
May 2018: Nature
https://www.readbyqxmd.com/read/29688378/biopanning-data-bank-2018-hugging-next-generation-phage-display
#7
Bifang He, Lixu Jiang, Yaocong Duan, Guoshi Chai, Yewei Fang, Juanjuan Kang, Min Yu, Ning Li, Zhongjie Tang, Pengcheng Yao, Pengcheng Wu, Ratmir Derda, Jian Huang
The BDB database is available at http://immunet.cn/bdb.
January 1, 2018: Database: the Journal of Biological Databases and Curation
https://www.readbyqxmd.com/read/29671316/monothioarsenate-occurrence-in-bangladesh-groundwater-and-its-removal-by-ferrous-and-zero-valent-iron-technologies
#8
Britta Planer-Friedrich, Jörg Schaller, Fabian Wismeth, Judith Mehlhorn, Stephan J Hug
In most natural groundwaters, sulfide concentrations are low and little attention has been paid to potential occurrence of thioarsenates (AsVSn-IIO4-n3- with n=1-4). Thioarsenate occurrence in groundwater could be critical with regard to the efficiency of iron (Fe)-based treatment technologies because previous studies reported less sorption of thioarsenates to preformed Fe-minerals compared to arsenite and arsenate. We analyzed 273 groundwater samples taken from different wells in Bangladesh over a year and detected monothioarsenate (MTA), likely formed via solid-phase zero-valent sulfur, in almost 50% of all samples...
April 19, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29663022/-diagnostics-and-conservative-treatment-of-cervical-and-lumbar-spinal-stenosis
#9
REVIEW
A Hug, S Hähnel, N Weidner
BACKGROUND: Degenerative stenotic spondylosis is not an uncommon cause of cervical spondylotic myelopathy (CSM) and cauda equina lesions in the aged population. Limited standardization exists with respect to diagnostic and therapeutic procedures. OBJECTIVE: Literature review with respect to diagnostic and therapeutic procedures for neurologically relevant cervical and lumbar spinals stenosis. MATERIAL AND METHODS: Comprehensive literature review...
April 16, 2018: Der Nervenarzt
https://www.readbyqxmd.com/read/29662075/the-unique-functioning-of-a-pre-columbian-amazonian-floodplain-fishery
#10
Rumsaïs Blatrix, Bruno Roux, Philippe Béarez, Gabriela Prestes-Carneiro, Marcelo Amaya, Jose Luis Aramayo, Leonor Rodrigues, Umberto Lombardo, Jose Iriarte, Jonas Gregorio de Souza, Mark Robinson, Cyril Bernard, Marc Pouilly, Mélisse Durécu, Carl F Huchzermeyer, Mashuta Kalebe, Alex Ovando, Doyle McKey
Archaeology provides few examples of large-scale fisheries at the frontier between catching and farming of fish. We analysed the spatial organization of earthen embankments to infer the functioning of a landscape-level pre-Columbian Amazonian fishery that was based on capture of out-migrating fish after reproduction in seasonal floodplains. Long earthen weirs cross floodplains. We showed that weirs bear successive V-shaped features (termed 'Vs' for the sake of brevity) pointing downstream for outflowing water and that ponds are associated with Vs, the V often forming the pond's downstream wall...
April 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29620995/3-versus-6-months-of-oxaliplatin-based-adjuvant-chemotherapy-for-patients-with-stage-iii-colon-cancer-disease-free-survival-results-from-a-randomized-open-label-international-duration-evaluation-of-adjuvant-idea-france-phase-iii-trial
#11
Thierry André, Dewi Vernerey, Laurent Mineur, Jaafar Bennouna, Jérôme Desrame, Roger Faroux, Serge Fratte, Marine Hug de Larauze, Sophie Paget-Bailly, Benoist Chibaudel, Jeremie Bez, Jérôme Dauba, Christophe Louvet, Céline Lepere, Olivier Dupuis, Yves Becouarn, May Mabro, Joëlle Egreteau, Olivier Bouche, Gaël Deplanque, Marc Ychou, Marie Pierre Galais, François Ghiringhelli, Louis Marie Dourthe, Jean-Baptiste Bachet, Ahmed Khalil, Franck Bonnetain, Aimery de Gramont, Julien Taieb
Purpose Reduction of adjuvant treatment duration may decrease toxicities without loss of efficacy in stage III colon cancer. This could offer clear advantages to patients and health care providers. Methods In International Duration Evaluation of Adjuvant Chemotherapy (IDEA) France, as part of the IDEA international collaboration, patient with colon cancer patients were randomly assigned to 3 and 6 months of modified FOLFOX6 (mFOLFOX6: infusional fluorouracil, leucovorin, and oxaliplatin) or capecitabine plus oxaliplatin (CAPOX) by physician choice...
April 5, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29616474/long-term-trends-in-swiss-rivers-sampled-continuously-over-39-years-reflect-changes-in-geochemical-processes-and-pollution
#12
Juerg Zobrist, Ursula Schoenenberger, Simon Figura, Stephan J Hug
Long-term changes of 14 water constituents measured in continuously and water discharge proportionally collected samples of four Swiss rivers over a period of 39 years are analyzed using several statistical techniques. Possible drivers and causes for the identified trends and shifts are explained by consideration of catchment characteristics and anthropogenic activities. Water temperatures increased by 0.8-1.3 °C, whereas water discharges remained largely unchanged. Concentrations of alkalinity, total hardness, Ca, and Mg regulated by dominant carbonate lithologies in catchments increased by up to 10%...
April 3, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29556533/it-takes-a-village-microbial-communities-thrive-through-interactions-and-metabolic-handoffs
#13
Laura A Hug, Rebecca Co
An enduring theme in microbial ecology is the interdependence of microbial community members. Interactions between community members include provision of cofactors, establishment of redox gradients, and turnover of key nutrients to drive biogeochemical cycles. Pathways canonically conducted by isolated organisms in laboratory cultures are instead collective products of diverse and interchangeable microbes in the environment. Current sequence-based methods provide unprecedented access to uncultivated microorganisms, allowing prediction of previously cryptic roles in biogeochemical cycles and interactions within communities...
March 2018: MSystems
https://www.readbyqxmd.com/read/29555836/computed-tomography-aortic-valve-calcium-scoring-in-patients-with-aortic-stenosis
#14
Tania Pawade, Marie-Annick Clavel, Christophe Tribouilloy, Julien Dreyfus, Tiffany Mathieu, Lionel Tastet, Cedric Renard, Mesut Gun, William Steven Arthur Jenkins, Laurent Macron, Jacob W Sechrist, Joan M Lacomis, Virginia Nguyen, Laura Galian Gay, Hug Cuéllar Calabria, Ioannis Ntalas, Timothy Robert Graham Cartlidge, Bernard Prendergast, Ronak Rajani, Arturo Evangelista, João L Cavalcante, David E Newby, Philippe Pibarot, David Messika Zeitoun, Marc R Dweck
BACKGROUND: Computed tomography aortic valve calcium scoring (CT-AVC) holds promise for the assessment of patients with aortic stenosis (AS). We sought to establish the clinical utility of CT-AVC in an international multicenter cohort of patients. METHODS AND RESULTS: Patients with AS who underwent ECG-gated CT-AVC within 3 months of echocardiography were entered into an international, multicenter, observational registry. Optimal CT-AVC thresholds for diagnosing severe AS were determined in patients with concordant echocardiographic assessments, before being used to arbitrate disease severity in those with discordant measurements...
March 2018: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29551264/dicer-like-enzymes-with-sequence-cleavage-preferences
#15
Cristina Hoehener, Iris Hug, Mariusz Nowacki
Dicer proteins are known to produce small RNAs (sRNAs) from long double-stranded RNA (dsRNA) templates. These sRNAs are bound by Argonaute proteins, which select the guide strand, often with a 5' end sequence bias. However, Dicer proteins have never been shown to have sequence cleavage preferences. In Paramecium development, two classes of sRNAs that are required for DNA elimination are produced by three Dicer-like enzymes: Dcl2, Dcl3, and Dcl5. Through in vitro cleavage assays, we demonstrate that Dcl2 has a strict size preference for 25 nt and a sequence preference for 5' U and 5' AGA, while Dcl3 has a sequence preference for 5' UNG...
March 1, 2018: Cell
https://www.readbyqxmd.com/read/29543463/halbach-effect-at-the-nanoscale-from-chiral-spin-textures
#16
Miguel A Marioni, Marcos Penedo, Mirko Baćani, Johannes Schwenk, Hans Josef Hug
Mallinson's idea that some spin textures in planar magnetic structures could produce an enhancement of the magnetic flux on one side of the plane at the expense of the other gave rise to permanent magnet configurations known as Halbach magnet arrays. Applications range from wiggler magnets in particle accelerators and free electron lasers, to motors, to magnetic levitation trains, but exploiting Halbach arrays in micro- or nanoscale spintronics devices requires solving the problem of fabrication and field metrology below 100 μm size...
March 15, 2018: Nano Letters
https://www.readbyqxmd.com/read/29538053/prevention-of-low-cardiac-output-syndrome-after-pediatric-cardiac-surgery-a-double-blind-randomized-clinical-pilot-study-comparing-dobutamine-and-milrinone
#17
Anna Cavigelli-Brunner, Maja I Hug, Hitendu Dave, Oskar Baenziger, Christoph Buerki, Dominique Bettex, Vincenzo Cannizzaro, Christian Balmer
OBJECTIVES: Dobutamine and milrinone are commonly used after open-heart surgery to prevent or treat low cardiac output syndrome. We sought to compare efficacy and safety of these drugs in pediatric patients. DESIGN: Prospective, single-center, double-blinded, randomized clinical pilot study. SETTING: Tertiary-care university children's hospital postoperative pediatric cardiac ICU. PATIENTS: After written consent, 50 consecutive patients (age, 0...
March 13, 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29513659/targeted-versus-non-targeted-hiv-testing-offered-via-electronic-questionnaire-in-a-swiss-emergency-department-a-randomized-controlled-study
#18
Cleo Gillet, Katharine E A Darling, Nicolas Senn, Matthias Cavassini, Olivier Hugli
BACKGROUND: In Switzerland, the national HIV testing recommendations propose targeted testing. Although the emergency department (ED) is mentioned specifically as a site where HIV testing should take place, the testing rate in our ED is 1% of patients seen. The aim of this study was to use electronic tablets to offer testing to ED patients and to examine whether non-targeted screening increased testing rates compared to targeted testing. METHODS: This randomised, cross-over design study took place at Lausanne University Hospital, Switzerland, between August and November 2015...
2018: PloS One
https://www.readbyqxmd.com/read/29511800/hypothenar-hammer-syndrome-caused-by-a-muscle-anomaly-a-case-report-with-review-of-the-literature
#19
Lea Estermann, Pascal Ducommun, Isabelle Steurer-Dober, Urs Hug
The hypothenar hammer syndrome (HHS) is a rare entity of secondary Raynaud's phenomenon. The blunt hypothenar trauma causes a lesion of the vessel wall with a consecutive thrombosis or aneurysm of the ulnar artery at the Guyon's canal. Different risk factors are discussed such as nicotine abuse, or a muscle anomaly in the Guyon's canal. To date, there are five case reports published about muscle anomalies and HHS. We present a case of a 51-year-old shipbuilder with a unilateral HHS on his right dominant hand with a bilateral muscle anomaly...
May 2018: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29494427/fewer-pills-do-not-mean-fewer-drug-drug-interactions-severe-rhabdomyolysis-on-elvitegravir-cobicistat-and-statin-treatment
#20
Carlo Perrone, Andri Rauch, Hansjakob Furrer, Markus Hug, Gilles Wandeler
No abstract text is available yet for this article.
March 13, 2018: AIDS
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