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https://www.readbyqxmd.com/read/29147849/heterogeneity-of-passive-elastic-properties-within-the-quadriceps-femoris-muscle-tendon-unit
#1
Brooke K Coombes, Brandon Ziegenfuss, Michael David, Rohitha Badya, Wolbert van den Hoorn, François Hug, Kylie Tucker
PURPOSE: The purpose of this study was to compare regional elastic properties between anterior and posterior regions of the patellar tendon, and individual quadriceps muscles, over a range of knee flexion angles. METHODS: An isokinetic dynamometer passively positioned the non-dominant knee of 19 young, healthy participants, at 25°, 40°, 55°, 70° and 85° flexion. Shear wave velocity (SWV, an index of tissue elasticity) was measured using ultrasound shear wave elastography in a relaxed (passive) state, confirmed by electromyography...
November 17, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29143461/do-animal-exhibitors-support-and-follow-recommendations-to-prevent-transmission-of-variant-influenza-at-agricultural-fairs-a-survey-of-animal-exhibitor-households-after-a-variant-influenza-virus-outbreak-in-michigan
#2
R J Stewart, J Rossow, J T Conover, E E Lobelo, S Eckel, K Signs, M G Stobierski, S C Trock, A M Fry, S J Olsen, M Biggerstaff
Influenza A viruses circulate in swine and can spread rapidly among swine when housed in close proximity, such as at agricultural fairs. Youth who have close and prolonged contact with influenza-infected swine at agricultural fairs may be at increased risk of acquiring influenza virus infection from swine. Animal and human health officials have issued written measures to minimize influenza transmission at agricultural exhibitions; however, there is little information on the knowledge, attitudes, and practice (KAP) of these measures among animal exhibitors...
November 16, 2017: Zoonoses and Public Health
https://www.readbyqxmd.com/read/29142387/fast-hugs-bid-modified-mnemonic-for-surgical-patient
#3
Abhijit S Nair, Vibhavari Milind Naik, Basanth Kumar Rayani
No abstract text is available yet for this article.
October 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29133793/binding-to-smn2-pre-mrna-protein-complex-elicits-specificity-for-small-molecule-splicing-modifiers
#4
Manaswini Sivaramakrishnan, Kathleen D McCarthy, Sébastien Campagne, Sylwia Huber, Sonja Meier, Angélique Augustin, Tobias Heckel, Hélène Meistermann, Melanie N Hug, Pascale Birrer, Ahmed Moursy, Sarah Khawaja, Roland Schmucki, Nikos Berntenis, Nicolas Giroud, Sabrina Golling, Manuel Tzouros, Balazs Banfai, Gonzalo Duran-Pacheco, Jens Lamerz, Ying Hsiu Liu, Thomas Luebbers, Hasane Ratni, Martin Ebeling, Antoine Cléry, Sergey Paushkin, Adrian R Krainer, Frédéric H-T Allain, Friedrich Metzger
Small molecule splicing modifiers have been previously described that target the general splicing machinery and thus have low specificity for individual genes. Several potent molecules correcting the splicing deficit of the SMN2 (survival of motor neuron 2) gene have been identified and these molecules are moving towards a potential therapy for spinal muscular atrophy (SMA). Here by using a combination of RNA splicing, transcription, and protein chemistry techniques, we show that these molecules directly bind to two distinct sites of the SMN2 pre-mRNA, thereby stabilizing a yet unidentified ribonucleoprotein (RNP) complex that is critical to the specificity of these small molecules for SMN2 over other genes...
November 14, 2017: Nature Communications
https://www.readbyqxmd.com/read/29128860/evaluation-of-different-dose-rate-combinations-of-ketamine-romifidine-and-azaperone-for-castration-of-3-4-and-5-6-weeks-old-piglets
#5
V H Cap, P J Hug, T Echtermann, S Von Ah, I Nussbaumer, F Janett, R Bettschart-Wolfensberger
In this study dose rate combinations of ketamine, azaperone and romifidine were tested in 3-4 (G3-4) and 5-6 weeks (G5-6) old piglets according to a dose rate decision tree (DRT) to provide calm anaesthesia induction, reaction-free anaesthesia for castration and smooth recovery within 2 hours. When a combination failed to meet those criteria in 2 piglets, the next dosage of the DRT was tested. In G3-4 four combinations were tested in 14 piglets with dose rates of 10-20 mg/kg ketamine, 3 mg/kg azaperone and 0...
November 2017: Schweizer Archiv Für Tierheilkunde
https://www.readbyqxmd.com/read/29118727/huggable-communication-medium-maintains-level-of-trust-during-conversation-game
#6
Hideyuki Takahashi, Midori Ban, Hirotaka Osawa, Junya Nakanishi, Hidenobu Sumioka, Hiroshi Ishiguro
There have been several attempts in recent years to develop a remote communication device using sensory modalities other than speech that would induce a user's positive experience with his/her conversation partner. Specifically, Hugvie is a human-shaped pillow as well as a remote communication device enabling users to combine a hugging experience with telecommunication to improve the quality of remote communication. The present research is based on the hypothesis that using Hugvie maintains users' level of trust toward their conversation partners in situations prone to suspicion...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29111508/hug-and-squeeze-using-crystals-to-incorporate-resonant-scattering-in-the-squeeze-structure-factor-contributions-to-determine-absolute-structure
#7
Richard I Cooper, Howard D Flack, David J Watkin
The resonant-scattering contributions to single-crystal X-ray diffraction data enable the absolute structure of crystalline materials to be determined. Crystal structures can be determined even if they contain considerably disordered regions because a correction is available via a discrete Fourier transform of the residual electron density to approximate the X-ray scattering from the disordered region. However, the corrected model cannot normally account for resonant scattering from atoms in the disordered region...
November 1, 2017: Acta Crystallographica. Section C, Structural Chemistry
https://www.readbyqxmd.com/read/29103049/challenges-to-informed-consent-in-first-in-human-trials-involving-novel-treatments-a-case-study-of-parkinson-s-disease
#8
Kristina Hug, Mats Johansson
Obtaining informed consent in clinical trials can be challenging both for researchers and for patients, albeit in different ways. The challenge concerns not only how to provide the needed information, but also what information to focus on when dealing with individual patients who have different goals, needs, histories, etc. This paper aims to contribute to a better informed consent process for Parkinson's patients taking part in first-in-human clinical trials of cell replacement therapies. It outlines a range of problems which patients and researchers may face in this process and provides practical advice to researchers engaged in such trials...
2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/29102129/an-overview-of-cochlear-implant-electrode-array-designs
#9
REVIEW
Anandhan Dhanasingh, Claude Jolly
Cochlear implant electrode arrays are designed with specific characteristics that allow for the preservation of intra-cochlear structures during the insertion process, as well as during explantation. Straight lateral wall (LW) electrode arrays and pre-curved modiolar hugging (MH) electrode arrays are the two types that are commercially available. Although there is a third type of electrode array called the mid-scala (MS), which is positioned in the middle of the scala tympani (ST), and is usually considered as an MH type of electrode...
October 18, 2017: Hearing Research
https://www.readbyqxmd.com/read/29100179/modeling-whole-body-trace-metal-concentrations-in-aquatic-invertebrate-communities-a-trait-based-approach
#10
Dorothea Hug Peter, Sylvain Sardy, Jairo Diaz Rodriguez, Emmanuel Castella, Vera I Slaveykova
Trace metal risk assessment and environmental quality standard definition require realistic models that quantify metal exposure and accumulation by biota. In the present study we propose a novel trait-based approach to predict whole body concentrations of metals in aquatic invertebrates from concentrations measured in different environmental compartments. Field data from a large riverine floodplain was used to calibrate and test the model. The prediction performance of the trait-based model was unbiased and uncertainty was below the twofold of measured concentrations for the four studied metals (Ni, Cu, Cd, Pb)...
October 31, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29099611/spect-ct-arthrography
#11
Ujwal Bhure, Justus E Roos, Maria Del Sol Pérez Lago, Isabelle Steurer, Hannes Grünig, Urs Hug, Klaus Strobel
Single photon emission CT (SPECT)/CT arthrography, the combination of CT arthrography and late phase bone SPECT/CT, has been developed in 2011 and so far used in knee, ankle and wrist joints. SPECT/CT offers functional information about increased bone turnover in combination with morphological details. Compared with SPECT/CT alone, additional intra-articular contrast enables the assessment of cartilage, menisci, ligaments and loose bodies. SPECT/CT arthrography is a promising alternative technique for the evaluation of internal derangement of joints in patients with MR contraindications and/or metallic implants...
November 16, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29097701/two-missense-mutations-in-kcnq1-cause-pituitary-hormone-deficiency-and-maternally-inherited-gingival-fibromatosis
#12
Johanna Tommiska, Johanna Känsäkoski, Lasse Skibsbye, Kirsi Vaaralahti, Xiaonan Liu, Emily J Lodge, Chuyi Tang, Lei Yuan, Rainer Fagerholm, Jørgen K Kanters, Päivi Lahermo, Mari Kaunisto, Riikka Keski-Filppula, Sanna Vuoristo, Kristiina Pulli, Tapani Ebeling, Leena Valanne, Eeva-Marja Sankila, Sirpa Kivirikko, Mitja Lääperi, Filippo Casoni, Paolo Giacobini, Franziska Phan-Hug, Tal Buki, Manuel Tena-Sempere, Nelly Pitteloud, Riitta Veijola, Marita Lipsanen-Nyman, Kari Kaunisto, Patrice Mollard, Cynthia L Andoniadou, Joel A Hirsch, Markku Varjosalo, Thomas Jespersen, Taneli Raivio
Familial growth hormone deficiency provides an opportunity to identify new genetic causes of short stature. Here we combine linkage analysis with whole-genome resequencing in patients with growth hormone deficiency and maternally inherited gingival fibromatosis. We report that patients from three unrelated families harbor either of two missense mutations, c.347G>T p.(Arg116Leu) or c.1106C>T p.(Pro369Leu), in KCNQ1, a gene previously implicated in the long QT interval syndrome. Kcnq1 is expressed in hypothalamic GHRH neurons and pituitary somatotropes...
November 3, 2017: Nature Communications
https://www.readbyqxmd.com/read/29095129/the-experience-of-fatigue-in-breast-cancer-patients-1-12-month-post-chemotherapy-a%C3%A2-qualitative%C3%A2-study
#13
Inbar Levkovich, Miri Cohen, Khaled Karkabi
The study explored the experience of fatigue, its effects and ways of coping with fatigue and the role of family and social support among breast cancer patients. In-depth, semi-structured interviews were conducted with 13 breast cancer patients stages I-III, aged 34-67, who were up to one year after the termination of chemotherapy. Two main themes emerged: "Being imprisoned in the body of an 80-year-old", focuses the fatigue experienced by younger and older women, during and post treatment, including the different patterns of fatigue and the various means of coping with fatigue; The "Family's bear-hug" exemplifies the role of the environment in coping with the experience of fatigue and the complexities entailed in receiving support from family and friends...
November 2, 2017: Behavioral Medicine
https://www.readbyqxmd.com/read/29091032/cyclic-di-gmp-differentially-tunes-a-bacterial-flagellar-motor-through-a-novel-class-of-chey-like-regulators
#14
Jutta Nesper, Isabelle Hug, Setsu Kato, Chee-Seng Hee, Judith Maria Habazettl, Pablo Manfredi, Stephan Grzesiek, Tilman Schirmer, Thierry Emonet, Urs Jenal
The flagellar motor is a sophisticated rotary machine facilitating locomotion and signal transduction. Owing to its important role in bacterial behavior, its assembly and activity are tightly regulated. For example, chemotaxis relies on a sensory pathway coupling chemical information to rotational bias of the motor through phosphorylation of the motor switch protein CheY. Using a chemical proteomics approach, we identified a novel family of CheY-like (Cle) proteins in Caulobacter crescentus, which tune flagellar activity in response to binding of the second messenger c-di-GMP to a C-terminal extension...
November 1, 2017: ELife
https://www.readbyqxmd.com/read/29076124/-long-term-outcome-analysis-of-subjective-and-objective-parameters-after-breast-reduction-in-159-cases-patients-judge-differently-from-plastic-surgeons
#15
Rik Osinga, Doris Babst, Elvira S Bodmer, Bjoern C Link, Elmar Fritsche, Urs Hug
Introduction This work assessed both subjective and objective postoperative parameters after breast reduction surgery and compared between patients and plastic surgeons. Patients and Methods After an average postoperative observation period of 6.7 ± 2.7 (2 - 13) years, 159 out of 259 patients (61 %) were examined. The mean age at the time of surgery was 37 ± 14 (15 - 74) years. The postoperative anatomy of the breast and other anthropometric parameters were measured in cm with the patient in an upright position...
October 26, 2017: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
https://www.readbyqxmd.com/read/29074777/second-messenger-mediated-tactile-response-by-a-bacterial-rotary-motor
#16
Isabelle Hug, Siddharth Deshpande, Kathrin S Sprecher, Thomas Pfohl, Urs Jenal
When bacteria encounter surfaces, they respond with surface colonization and virulence induction. The mechanisms of bacterial mechanosensation and downstream signaling remain poorly understood. Here, we describe a tactile sensing cascade in Caulobacter crescentus in which the flagellar motor acts as sensor. Surface-induced motor interference stimulated the production of the second messenger cyclic diguanylate by the motor-associated diguanylate cyclase DgcB. This led to the allosteric activation of the glycosyltransferase HfsJ to promote rapid synthesis of a polysaccharide adhesin and surface anchoring...
October 27, 2017: Science
https://www.readbyqxmd.com/read/29069312/pesto-parameter-estimation-toolbox
#17
Paul Stapor, Daniel Weindl, Benjamin Ballnus, Sabine Hug, Carolin Loos, Anna Fiedler, Sabrina Krause, Sabrina Hroß, Fabian Fröhlich, Jan Hasenauer
Summary: PESTO is a widely applicable and highly customizable toolbox for parameter estimation in MathWorks MATLAB. It offers scalable algorithms for optimization, uncertainty and identifiability analysis, which work in a very generic manner, treating the objective function as a black box. Hence, PESTO can be used for any parameter estimation problem, for which the user can provide a deterministic objective function in MATLAB. Availability and Implementation: PESTO is a MATLAB toolbox, freely available under the BSD license...
October 23, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29057490/when-cars-hit-trucks-and-girls-hug-boys-the-effect-of-animacy-on-word-order-in-gestural-language-creation
#18
Annemarie Kocab, Hannah Lam, Jesse Snedeker
A well-known typological observation is the dominance of subject-initial word orders, SOV and SVO, across the world's languages. Recent findings from gestural language creation paradigms offer possible explanations for the prevalence of SOV. When asked to gesture transitive events with an animate agent and inanimate patient, gesturers tend to produce SOV order, regardless of their native language biases. Interestingly, when the patient is animate, gesturers shift away from SOV to use of other orders, like SVO and OSV...
October 23, 2017: Cognitive Science
https://www.readbyqxmd.com/read/29057469/beyond-lots-of-hugs-and-kisses-expressions-of-parental-love-from-parents-and-their-young-children-in-two-parent-financially-stable-families
#19
Allen K Sabey, Amy J Rauer, Megan L Haselschwerdt, Brenda Volling
Given that parental love is essential for children's optimal development, the current study gathered examples of how parental love was demonstrated within parent-child relationships. Fifty-eight two-parent, financially stable families consisting of a mother, father, and young child (3-7 years old) from the Midwest were interviewed regarding how they demonstrated or perceived parental love. Results from an inductive thematic analysis revealed considerable variability in how parental love was demonstrated, with five themes emerging that overlapped between parents and their children: playing or doing activities together, demonstrating affection, creating structure, helping or supporting, and giving gifts or treats...
October 22, 2017: Family Process
https://www.readbyqxmd.com/read/29054384/arthroscopic-subscapularis-repair-using-single-row-mattress-suture-technique-clinical-results-and-structural-integrity
#20
Jeung Yeol Jeong, Hai-Le Pan, Seung Yeop Song, Sang Min Lee, Jae Chul Yoo
BACKGROUND: Rupture of the subscapularis (SSC) tendon, isolated or combined, is rare, and the treatment modalities are controversial. The purpose of this study was to evaluate, by magnetic resonance imaging (MRI), the clinical outcomes and structural integrity of the SSC tendon after all-arthroscopic repair with single-row mattress suture for isolated or combined SSC tendon tears. METHODS: This study included 68 patients who underwent all-arthroscopic repair using single-row mattress suture for isolated or combined SSC tendon tears between April 2011 and January 2013...
October 17, 2017: Journal of Shoulder and Elbow Surgery
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