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Karthik Anantharaman, Christopher T Brown, Laura A Hug, Itai Sharon, Cindy J Castelle, Alexander J Probst, Brian C Thomas, Andrea Singh, Michael J Wilkins, Ulas Karaoz, Eoin L Brodie, Kenneth H Williams, Susan S Hubbard, Jillian F Banfield
The subterranean world hosts up to one-fifth of all biomass, including microbial communities that drive transformations central to Earth's biogeochemical cycles. However, little is known about how complex microbial communities in such environments are structured, and how inter-organism interactions shape ecosystem function. Here we apply terabase-scale cultivation-independent metagenomics to aquifer sediments and groundwater, and reconstruct 2,540 draft-quality, near-complete and complete strain-resolved genomes that represent the majority of known bacterial phyla as well as 47 newly discovered phylum-level lineages...
October 24, 2016: Nature Communications
Michael X Repka, Trevano W Dean, Elizabeth L Lazar, Kimberly G Yen, Phoebe D Lenhart, Sharon F Freedman, Denise Hug, Bahram Rahmani, Serena X Wang, Raymond T Kraker, David K Wallace
OBJECTIVE: To describe baseline characteristics, initial postoperative refractive errors, operative complications, and magnitude of the intraocular lens (IOL) prediction error for refractive outcome in children undergoing lensectomy largely in North America. DESIGN: Prospective registry study of children from birth to <13 years of age who underwent lensectomy for any reason within 45 days preceding enrollment. PARTICIPANTS: Total of 1266 eyes of 994 children; 49% female and 59% white...
October 18, 2016: Ophthalmology
Juul Verberne, Frank Risis, Luke Campbell, Scott Chambers, Stephen O'Leary
HYPOTHESIS: Scala tympani morphology influences the insertion dynamics and intra-scalar position of straight electrode arrays. BACKGROUND: Hearing preservation is the goal of cochlear implantation with current thin straight electrode arrays. These hug the lateral wall, facilitating full, atraumatic insertions. However, most studies still report some postoperative hearing loss. This study explores the influence of scala tympani morphology on array position relative to the basilar membrane and its possible contribution to postoperative hearing loss...
October 12, 2016: Otology & Neurotology
Ryan E Stafford, Rafeef Aljuraifani, François Hug, Paul W Hodges
OBJECTIVES: To investigate whether increases in stiffness can be detected in the anatomical region associated with the striated urethral sphincter during voluntary activation using shear wave elastography; to identify the location and area of the stiffness increase relative to the point of greatest dorsal displacement of the mid urethra (i.e. striated urethral sphincter); and to determine the relationship between muscle stiffness and contraction intensity. SUBJECTS AND METHODS: Ten healthy men participated...
October 18, 2016: BJU International
Judith L Griffin, Marie Yersin, Stéphanie Baggio, Katia Iglesias, Venetia-Sofia Velonaki, Karine Moschetti, Bernard Burnand, Jean-Blaise Wasserfallen, Francis Vu, Corine Ansermet, Olivier Hugli, Jean-Bernard Daeppen, Patrick Bodenmann
OBJECTIVES: Frequent Emergency Department (ED) users have an elevated mortality, yet little is known about risk factors. Our aim was to characterize deceased frequent ED users and determine predictors of mortality. METHODS: This is a post-hoc analysis of all-cause mortality among frequent ED users participating in a randomized clinical trial on case management at the Lausanne University Hospital (Switzerland). We enrolled 250 frequent ED users (5+ visits/past year) in a 12-month randomized clinical trial; those with an estimated survival of fewer than 18 months were excluded...
October 4, 2016: European Journal of Emergency Medicine: Official Journal of the European Society for Emergency Medicine
Nicolas Faller, Andreas Limacher, Marie Méan, Marc Righini, Markus Aschwanden, Jürg Hans Beer, Beat Frauchiger, Josef Osterwalder, Nils Kucher, Bernhard Lämmle, Jacques Cornuz, Anne Angelillo-Scherrer, Christian M Matter, Marc Husmann, Martin Banyai, Daniel Staub, Lucia Mazzolai, Olivier Hugli, Nicolas Rodondi, Drahomir Aujesky
BACKGROUND: Long-term predictors and causes of death are understudied in elderly patients with acute venous thromboembolism. METHODS: We prospectively followed-up 991 patients aged ≥65 years with acute venous thromboembolism in a multicenter Swiss cohort study. The primary outcome was overall mortality. We explored the association between patient baseline characteristics and mortality, adjusting for other baseline variables and periods of anticoagulation as a time-varying co-variate...
October 11, 2016: American Journal of Medicine
Çiğdem Özkara, Emine Taşkıran, İrem Yıldırım Çarpraz, Erhan Bilir, Aylin Bican Demir, İbrahim Bora, İbrahim Aydoğdu, Şakir Delil, Francine Chassoux
PURPOSE: The study aimed to describe the electroclinical features of ictal kissing, an unusual behavior that may occur during focal seizures. METHOD: Twenty-five patients collected from four epilepsy centers and previously published reports were reviewed for their demographic, clinical, and electrophysiological features. RESULTS: Sixteen of 25 patients were female. The mean age was 32.9 years (9.9-51 years) and the average age at seizure onset was 14...
October 1, 2016: Seizure: the Journal of the British Epilepsy Association
Yves Jackson, Juan Carlos Lozano Becerra, Marc Carpentier
BACKGROUND: Socioeconomic disadvantage is associated with an increased risk of adverse diabetes outcomes. In Switzerland, a country with theoretical universal healthcare coverage, people without health insurance face barriers in accessing to and in receiving standard quality care. The Geneva University Hospitals (HUG) have implemented policies aiming at reducing these gaps. We compared quality of diabetes care and ambulatory healthcare services utilization among insured and uninsured diabetic patients...
October 3, 2016: BMC Health Services Research
Makoto Iijima, Hug Aubin, Meike Steinbrink, Franziska Schiffer, Alexander Assmann, Richard D Weisel, Yoshiro Matsui, Ren-Ke Li, Artur Lichtenberg, Payam Akhyari
The ideal small-diameter vascular graft for widespread clinical application has not yet been developed and current approaches still suffer from graft failure because of thrombosis or degeneration. Decellularized vascular grafts are a promising strategy as they preserve native vessel architecture while eliminating cell-based antigens and allowing for autologous recellularization. In this study, we used a functional in vivo rodent aortic transplantation model in order to evaluate the benefit of bio-active coating of decellularized vascular grafts with vascular endothelial growth factor (VEGF) conjugated to a temperature-sensitive aliphatic polyester hydrogel (HG)...
September 30, 2016: Journal of Tissue Engineering and Regenerative Medicine
Z Harry Piotrowski, Donald Hedeker
OBJECTIVES: To investigate the impact of Be the Exception, a newly developed program to delay onset of sexual behaviors, in a White, rural population. METHODS: A cluster randomized controlled trial in northwestern Indiana (14 schools, 1776 students, 2011-2015) compared an intervention (5 group sessions and multimedia assembly) with a no-intervention group; both continued usual standard health education. Multilevel mixed-effects logistic regressions with 1455 students measured long-term outcomes 12 months after baseline questionnaire...
September 2016: American Journal of Public Health
Dennis P Dimaculangan, Jonathan A Mazer, Luiz F Maracaja-Neto
OBJECTIVE: To find the position that provided the most comfort, as well as the widest L3-L4 interlaminar space opening. DESIGN: Pilot study. SETTING: Operating room. PATIENTS: Thirty-two healthy volunteers. INTERVENTIONS: L3-L4 interlaminar space was measured on volunteers assuming a baseline position (sitting upright) and 5 study positions: (1) sitting in fetal position, (2) sitting on a table tilted at 30°, (3) sitting while hugging an exercise ball, (4) sitting with midcalves on the table's edge, and (5) lying on one side in fetal position...
November 2016: Journal of Clinical Anesthesia
Kanu Okike, Kevin T Hug, Mininder S Kocher, Seth S Leopold
No abstract text is available yet for this article.
September 27, 2016: JAMA: the Journal of the American Medical Association
Anna L Hatton, François Hug, Sarah H Chen, Christine Reid, Nicole A Sorensen, Kylie Tucker
Middle-aged adults with painful hip conditions show balance impairments that are consistent with an increased risk of falls. Pathological changes at the hip, accompanied by pain, may accelerate pre-existing age-related balance deficits present in midlife. To consider the influence of pain alone, we investigated the effects of acute experimental hip muscle pain on dynamic single-limb balance in middle-aged adults. Thirty-four healthy adults aged 40-60 years formed two groups (Group-1: n=16; Group-2: n=18). Participants performed four tasks: Reactive Sideways Stepping (ReactSide); Star Excursion Balance Test (SEBT); Step Test; Single-Limb Squat; before and after an injection of hypertonic saline into the right gluteus medius muscle (Group-1) or ∼5min rest (Group-2)...
September 13, 2016: Gait & Posture
María N Pizzi, Albert Roque, Hug Cuéllar-Calabria, Nuria Fernández-Hidalgo, Ignacio Ferreira-González, María T González-Alujas, Alberto Igual-Barceló, David Garcia-Dorado, Benito Almirante, Joan Castell-Conesa, Manuel Escobar Amores, Pilar Tornos, Santiago Aguadé-Bruix
No abstract text is available yet for this article.
October 2016: JACC. Cardiovascular Imaging
Sarah A Vannier, Natalie O Rosen, Sean P Mackinnon, Sophie Bergeron
Provoked vestibulodynia (PVD) is a recurrent, genito-pelvic pain condition that affects 8-12 % of women and has negative implications for sexual and relationship functioning. Many women with PVD report avoiding physical affection because they are concerned that affectionate behavior will lead to painful sexual activity. In community samples, physical affection is associated with improved sexual and relational well-being; however, no research has assessed the influence of physical affection on well-being in women with PVD...
September 12, 2016: Archives of Sexual Behavior
Laura A Hug, Brett J Baker, Karthik Anantharaman, Christopher T Brown, Alexander J Probst, Cindy J Castelle, Cristina N Butterfield, Alex W Hernsdorf, Yuki Amano, Kotaro Ise, Yohey Suzuki, Natasha Dudek, David A Relman, Kari M Finstad, Ronald Amundson, Brian C Thomas, Jillian F Banfield
The tree of life is one of the most important organizing principles in biology(1). Gene surveys suggest the existence of an enormous number of branches(2), but even an approximation of the full scale of the tree has remained elusive. Recent depictions of the tree of life have focused either on the nature of deep evolutionary relationships(3-5) or on the known, well-classified diversity of life with an emphasis on eukaryotes(6). These approaches overlook the dramatic change in our understanding of life's diversity resulting from genomic sampling of previously unexamined environments...
2016: Nature Microbiology
Roi Strulovich, William Sam Tobelaim, Bernard Attali, Joel A Hirsch
The Kv7 (KCNQ) channel family, comprising voltage-gated potassium channels, plays major roles in fine-tuning cellular excitability by reducing firing frequency and controlling repolarization. Kv7 channels have a unique intracellular C-terminal (CT) domain bound constitutively by calmodulin (CaM). This domain plays key functions in channel tetramerization, trafficking, and gating. CaM binds to the proximal CT, comprising helices A and B. Kv7.2 and Kv7.3 are expressed in neural tissues. Together, they form the heterotetrameric M channel...
September 27, 2016: Biochemistry
Sauro Salomoni, Kylie Tucker, François Hug, Megan McPhee, Paul Hodges
Although maximal voluntary contraction (MVC) force is reduced during pain, studies using interpolated twitch show no consistent reduction of voluntary muscle drive. The present study aimed to test if the reduction in MVC force during acute experimental pain could be explained by increased activation of antagonist muscles, weak voluntary activation at baseline, or changes in force direction. Twenty-two healthy volunteers performed maximal voluntary isometric knee extensions before, during, and after the effects of hypertonic (pain) and isotonic (control) saline injections into the infrapatellar fat pad...
2016: PloS One
Piotr Filipiak, Krzysztof Bobrowski, Gordon L Hug, Dariusz Pogocki, Christian Schöneich, Bronislaw Marciniak
The mechanism of oxidation processes of l-Met-(Pro)n-l-Met peptides that contain two Met residues located on the N- and C-terminal and separated by a defined number (n = 0-4) of proline residues was investigated in aqueous solutions using pulse radiolysis. The use of such peptides allowed for distance control between the sulfur atoms located in the side chains of the Met residues. The formation of a contact between the side chains of the Met residues was probed by the observation of transients with σ*-type 2c-3e S∴S and S∴O bonds as well as of α-(alkylthio)alkyl radicals (αS)...
September 15, 2016: Journal of Physical Chemistry. B
Eveline Hofmann, Andreas Limacher, Marie Méan, Nils Kucher, Marc Righini, Beat Frauchiger, Jürg-Hans Beer, Joseph Osterwalder, Markus Aschwanden, Christian M Matter, Martin Banyai, Michael Egloff, Olivier Hugli, Daniel Staub, Henri Bounameaux, Nicolas Rodondi, Drahomir Aujesky
BACKGROUND: The evidence on the prognostic value of transthoracic echocardiography (TTE) in elderly, hemodynamically stable patients with Pulmonary Embolism (PE) is limited. OBJECTIVES: To evaluate the prevalence of common echocardiographic signs of right ventricular (RV) dysfunction and their prognostic impact in hemodynamically stable patients aged ≥65years with acute PE in a prospective multicenter cohort. METHODS: TTE was performed by cardiologists...
September 2016: Thrombosis Research
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