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https://www.readbyqxmd.com/read/28293474/transition-from-oxcarbazepine-to-eslicarbazepine-acetate-a-single-center-study
#1
Jussi Mäkinen, Sirpa Rainesalo, Jukka Peltola
OBJECTIVES: There is limited clinical evidence for comparison between oxcarbazepine (OXC) and eslicarbazepine acetate (ESL) in terms of tolerability, or how to execute the change from OXC to ESL. We report the process of transitioning patients with focal epilepsy from previous OXC treatment to ESL due to tolerability problems. The rationale for change from OXC is reported, and the outcome with respective to this rationale is analyzed in terms of tolerability and efficacy. MATERIALS AND METHODS: The subjects were transitioned overnight from OXC to ESL in a hospital inpatient setting...
March 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28282542/the-effect-of-newer-antiepileptic-drugs-in-combination-therapy
#2
Jussi Mäkinen, Sirpa Rainesalo, Jani Raitanen, Jukka Peltola
PURPOSE: To assess the impact of the new AEDs on overall outcome for patients with epilepsy. METHODS: In 2004, the effect of combination therapy on seizure frequency in adult patients with focal epilepsy was evaluated in a cross-sectional study in our center. We repeated this analysis ten years and eight new antiepileptic drugs (AED) later. RESULTS: In 2014, a higher percentage of patients with polytherapy (117 out of 396; 30%) were seizure-free compared with the original analysis (22%) (p=0...
March 2, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28278245/regional-changes-in-psychotropic-use-among-finnish-persons-with-newly-diagnosed-alzheimer-s-disease-in-2005-2011
#3
Anna-Maija Tolppanen, Ari Voutilainen, Heidi Taipale, Antti Tanskanen, Piia Lavikainen, Marjaana Koponen, Jari Tiihonen, Sirpa Hartikainen
OBJECTIVES: To describe and compare temporal changes in prevalence and incidence of psychotropic use (antipsychotics, antidepressants and benzodiazepines and related drugs; BZDRs) in persons with newly diagnosed Alzheimer's disease (AD) between university hospital districts of Finland during 2005-2011. METHODS: The MEDALZ study includes all community-dwellers of Finland who received a clinically verified AD diagnosis in 2005-2011 (N = 70,718). Prevalent and incident use of psychotropics among those who had received AD diagnosis less than one year ago were compared in 2005-2011...
2017: PloS One
https://www.readbyqxmd.com/read/28274328/risk-of-alzheimer-s-disease-among-users-of-postmenopausal-hormone-therapy-a-nationwide-case-control-study
#4
Bushra Imtiaz, Heidi Taipale, Antti Tanskanen, Miia Tiihonen, Miia Kivipelto, Anna-Mari Heikkinen, Jari Tiihonen, Hilkka Soininen, Sirpa Hartikainen, Anna-Maija Tolppanen
OBJECTIVE: To examine the association between postmenopausal hormone therapy (HT) and Alzheimer's disease (AD). METHODS: Medicine and Alzheimer's disease (MEDALZ) is a nested case-control study of the entire Finnish population with clinically verified AD from 2005 to 2011 and up to 4 matched controls per case. This study comprises 230,580 women (46,117 cases and 184,463 controls). Data on HT use from 1995 to 2011 was extracted from the national prescription register using following ATC codes: G03C (estrogen), G03D (progestogen) and G03F (estrogen and progestogen in combination)...
April 2017: Maturitas
https://www.readbyqxmd.com/read/28271611/nlrp3-inflammasome-activation-is-associated-with-proliferative-diabetic-retinopathy
#5
Sirpa Loukovaara, Niina Piippo, Kati Kinnunen, Maria Hytti, Kai Kaarniranta, Anu Kauppinen
PURPOSE: Innate immunity and dysregulation of inflammatory processes play a role in vascular diseases like atherosclerosis or diabetes. Nucleotide-binding domain and Leucine-rich repeat Receptor containing a Pyrin domain 3 (NLRP3) inflammasomes are pro-inflammatory signalling complexes that were found in 2002. In addition to pathogens and other extracellular threats, they can be activated by various endogenous danger signals. The purpose of this study was to find out whether NLRP3 activation occurs in patients with sight-threatening forms of diabetic retinopathy (DR)...
March 8, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28268219/treg-cells-protect-dopaminergic-neurons-against-mpp-neurotoxicity-via-cd47-sirpa-interaction
#6
Yan Huang, Zhan Liu, Bei-Bei Cao, Yi-Hua Qiu, Yu-Ping Peng
BACKGROUND/AIMS: Regulatory T (Treg) cells have been associated with neuroprotection by inhibiting microglial activation in animal models of Parkinson's disease (PD), a progressive neurodegenerative disease characterized by dopaminergic neuronal loss in the nigrostriatal system. Herein, we show that Treg cells directly protect dopaminergic neurons against 1-methyl-4-phenylpyridinium (MPP+) neurotoxicity via an interaction between the two transmembrane proteins CD47 and signal regulatory protein α (SIRPA)...
March 7, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28251930/amine-oxidase-activity-regulates-the-development-of-pulmonary-fibrosis
#7
Fumiko Marttila-Ichihara, Kati Elima, Kaisa Auvinen, Tibor Z Veres, Pia Rantakari, Christopher Weston, Masayuki Miyasaka, David Adams, Sirpa Jalkanen, Marko Salmi
In pulmonary fibrosis, an inflammatory reaction and differentiation of myofibroblasts culminate in pathologic deposition of collagen. Amine oxidase copper containing-3 (AOC3) is a cell-surface expressed oxidase that regulates leukocyte extravasation. Here we analyzed the potential role of AOC3 using gene-modified and inhibitor-treated mice in a bleomycin-induced pulmonary fibrosis model. Inflammation and fibrosis of lungs were assessed by histologic, flow cytometric, and quantitative PCR analysis. AOC3-deficient mice showed a 30-50% reduction in fibrosis, collagen synthesis, numbers of myofibroblasts, and accumulation of CD4(+) lymphocytes, NK T cells, macrophages, and type 2 innate lymphoid cells compared with wild-type control mice...
March 1, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28200017/preventive-oral-health-intervention-among-old-home-care-clients
#8
Annamari Nihtilä, Eveliina Tuuliainen, Kaija Komulainen, Kirsi Autonen-Honkonen, Irma Nykänen, Sirpa Hartikainen, Riitta Ahonen, Miia Tiihonen, Anna Liisa Suominen
No abstract text is available yet for this article.
February 14, 2017: Age and Ageing
https://www.readbyqxmd.com/read/28186141/spatial-variations-in-the-molecular-diversity-of-dissolved-organic-matter-in-water-moving-through-a-boreal-forest-in-eastern-finland
#9
Jun'ichiro Ide, Mizue Ohashi, Katsutoshi Takahashi, Yuko Sugiyama, Sirpa Piirainen, Pirkko Kortelainen, Nobuhide Fujitake, Keitaro Yamase, Nobuhito Ohte, Mina Moritani, Miyako Hara, Leena Finér
Dissolved organic matter (DOM) strongly affects water quality within boreal forest ecosystems. However, how the quality of DOM itself changes spatially is not well understood. In this study, to examine how the diversity of DOM molecules varies in water moving through a boreal forest, the number of DOM molecules in different water samples, i.e., rainwater, throughfall, soil water, groundwater, and stream water was determined using Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) in Norway spruce and Scots pine stands in eastern Finland during May and June 2010...
February 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28183850/deltex-1-mutations-predict-poor-survival-in-diffuse-large-b-cell-lymphoma
#10
Leo Meriranta, Annika Pasanen, Riku Louhimo, Alejandra Cervera, Amjad Alkodsi, Matias Autio, Minna Taskinen, Ville Rantanen, Marja-Liisa Karjalainen-Lindsberg, Harald Holte, Jan Delabie, Rainer Lehtonen, Sampsa Hautaniemi, Sirpa Leppä
No abstract text is available yet for this article.
February 9, 2017: Haematologica
https://www.readbyqxmd.com/read/28181393/blepharocheilodontic-bcd-syndrome-new-insights-on-craniofacial-and-dental-features
#11
Wael Awadh, Anu Kiukkonen, Pekka Nieminen, Sirpa Arte, Kirsti Hurmerinta, David P Rice
Blepharocheilodontic (BCD) syndrome is a rare condition characterized by bilateral cleft lip and palate (BCLP), eyelid abnormalities, and oligodontia. Despite orofacial clefting and oligodontia being central features of the condition, detailed reports of dental and craniofacial characteristics are scarce. The aim of this study was to analyze the dental and craniofacial features in a group of patients with BCD syndrome (three of which were related). Cephalometric radiographic analyses were performed on BCD syndrome patients (all radiographs taken at age 8 years) and compared to 40 randomly selected age-matched controls (20 non-syndromic BCLP, 20 non-cleft)...
February 9, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28179338/cancer-death-risk-related-to-radiation-exposure-from-computed-tomography-scanning-among-testicular-cancer-patients
#12
Eeva Salminen, Hannele Niiniviita, Hannu Järvinen, Sirpa Heinävaara
BACKGROUND: A study of the computed tomography (CT) imaging related effective doses and radiation-related cancer death risk. PATIENTS AND METHODS: Estimate effective doses were computed from CT scans of testicular cancer patients treated and followed-up in Turku University Hospital, South Western Finland. Association between effective doses from follow-up CT scans and radiation-induced cancer death was examined using United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR) 2008 formula...
2017: Anticancer Research
https://www.readbyqxmd.com/read/28161898/the-relationship-between-loading-history-and-proximal-femoral-diaphysis-cross-sectional-geometry
#13
Sirpa Niinimäki, Nathaniel Narra, Laura Härkönen, Shinya Abe, Riku Nikander, Jari Hyttinen, Christopher Knüsel, Harri Sievänen
OBJECTIVES: We investigated the relationship between loading history and bone biomechanical properties used in physical activity reconstructions. These bone properties included bone bending and torsional strength (J), cortical area (CA), the direction of the major axis (theta angle), and element shape ratios determined from cross sections of standardized bone length. In addition, we explored the applicability of anatomically determined cross sections. METHODS: Our material consisted of hip and proximal thigh magnetic resonance images of Finnish female athletes (N = 91) engaged in high-jump, triple-jump, endurance running, swimming, power-lifting, soccer and squash; along with a group of active non-athlete individuals (N = 20)...
February 5, 2017: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/28146612/antipsychotic-use-and-the-risk-of-hip-fracture-among-community-dwelling-persons-with-alzheimer-s-disease
#14
Marjaana Koponen, Heidi Taipale, Piia Lavikainen, Antti Tanskanen, Jari Tiihonen, Anna-Maija Tolppanen, Riitta Ahonen, Sirpa Hartikainen
OBJECTIVE: To study whether antipsychotic use is associated with a risk of hip fracture among individuals with Alzheimer's disease and to compare the risk according to the duration of use and the 2 most frequently used antipsychotics. METHODS: The MEDALZ (Medication and Alzheimer's disease) cohort consisted of community-dwelling Finnish persons with clinically verified diagnoses of Alzheimer's disease, including 70,718 persons newly diagnosed according to NINCDS-ADRDA and DSM-IV criteria between 2005 and 2011...
January 31, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28140388/de-novo-transcriptome-assemblies-of-four-accessions-of-the-metal-hyperaccumulator-plant-noccaea-caerulescens
#15
Daniel Blande, Pauliina Halimaa, Arja I Tervahauta, Mark G M Aarts, Sirpa O Kärenlampi
Noccaea caerulescens of the Brassicaceae family has become the key model plant among the metal hyperaccumulator plants. Populations/accessions of N. caerulescens from geographic locations with different soil metal concentrations differ in their ability to hyperaccumulate and hypertolerate metals. Comparison of transcriptomes in several accessions provides candidates for detailed exploration of the mechanisms of metal accumulation and tolerance and local adaptation. This can have implications in the development of plants for phytoremediation and improved mineral nutrition...
January 31, 2017: Scientific Data
https://www.readbyqxmd.com/read/28137475/physical-activity-after-a-hip-fracture-effect-of-a-multicomponent-home-based-rehabilitation-program-a-secondary-analysis-of-a-randomized-controlled-trial
#16
Katri Turunen, Anu Salpakoski, Johanna Edgren, Timo Törmäkangas, Marja Arkela, Mauri Kallinen, Maija Pesola, Sirpa Hartikainen, Riku Nikander, Sarianna Sipilä
OBJECTIVES: To investigate the effect of a yearlong multicomponent rehabilitation program on the level of physical activity (PA) and the maintenance of the level of PA over one year follow-up among older people recovering from a recent hip fracture. DESIGN: Secondary analysis of a randomized, controlled, parallel-group trial. SETTING: Home-based rehabilitation; measurements in university laboratory. PARTICIPANTS: Community-dwelling people aged 60+ recovering from a hip fracture...
January 27, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28132144/oat-anther-culture-and-use-of-dh-lines-for-genetic-mapping
#17
Elina Kiviharju, Sirpa Moisander, Pirjo Tanhuanpää
Possibility to make doubled haploids (DHs) from varying crossing populations is a useful tool for enhancing cultivar breeding, and a source of valuable material for genetic research. Oats is reported to be recalcitrant in anther culture with low response and genotype dependency. However, the best recoveries reported have reached up to 30 green regenerants per 100 isolated anthers, which clearly addresses the potential of this technique. In this chapter, one successful oat anther culture protocol is described in detail...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28122643/identification-of-potential-saliva-and-tear-biomarkers-in-primary-sj%C3%A3-gren-s-syndrome-utilising-the-extraction-of-extracellular-vesicles-and-proteomics-analysis
#18
Lara A Aqrawi, Hilde Kanli Galtung, Beate Vestad, Reidun Øvstebø, Bernd Thiede, Shermin Rusthen, Alix Young, Eduarda M Guerreiro, Tor Paaske Utheim, Xiangjun Chen, Øygunn Aass Utheim, Øyvind Palm, Janicke Liaaen Jensen
BACKGROUND: There is a long-lasting need for non-invasive, more accurate diagnostic techniques when evaluating primary Sjögren's syndrome (pSS) patients. Incorporation of additional diagnostics involving screening for disease-specific biomarkers in biological fluid is a promising concept that requires further investigation. In the current study we aimed to explore novel disease biomarkers in saliva and tears from pSS patients. METHODS: Liquid chromatography-mass spectrometry (LC-MS) was performed on stimulated whole saliva and tears from 27 pSS patients and 32 healthy controls, and salivary and tear proteomic biomarker profiles were generated...
January 25, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28100392/replication-study-the-cd47-signal-regulatory-protein-alpha-sirpa-interaction-is-a-therapeutic-target-for-human-solid-tumors
#19
Stephen K Horrigan
In 2015, as part of the Reproducibility Project: Cancer Biology, we published a Registered Report (Chroscinski et al., 2015) that described how we intended to replicate selected experiments from the paper "The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors "(Willingham et al., 2012). Here we report the results of those experiments. We found that treatment of immune competent mice bearing orthotopic breast tumors with anti-mouse CD47 antibodies resulted in short-term anemia compared to controls, consistent with the previously described function of CD47 in normal phagocytosis of aging red blood cells and results reported in the original study (Table S4; Willingham et al...
January 19, 2017: ELife
https://www.readbyqxmd.com/read/28092324/long-term-use-of-opioids-for-nonmalignant-pain-among-community-dwelling-persons-with-and-without-alzheimer-disease-in-finland-a-nationwide-register-based-study
#20
Aleksi Hamina, Heidi Taipale, Antti Tanskanen, Anna-Maija Tolppanen, Niina Karttunen, Liisa Pylkkänen, Jari Tiihonen, Sirpa Hartikainen
Persons with Alzheimer disease (AD) commonly present with chronic nonmalignant pain, but long-term use of opioids among this population has not been studied previously. Our aim was to investigate the prevalence of long-term (≥180 days) use of opioids for nonmalignant pain and associated factors among community-dwelling persons with AD and to compare the prevalence with a matched cohort without AD. The Medication use and Alzheimer's disease (MEDALZ) cohort was used for this study, comprising all community-dwelling persons diagnosed with AD in Finland during 2005 to 2011 and their matched comparison persons without AD...
February 2017: Pain
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