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https://www.readbyqxmd.com/read/28699419/chair-rise-capacity-and-associated-factors-in-older-home-care-clients
#1
Miia Tiihonen, Sirpa Hartikainen, Irma Nykänen
AIMS: The aim of this study was to investigate the ability of older home-care clients to perform the five times chair rise test and associated personal characteristics, nutritional status and functioning. METHODS: The study sample included 267 home-care clients aged ≥75 years living in Eastern and Central Finland. The home-care clients were interviewed at home by home-care nurses, nutritionists and pharmacists. The collected data contained sociodemographic factors, functional ability (Barthel Index, IADL), cognitive functioning (MMSE), nutritional status (MNA), depressive symptoms (GDS-15), medical diagnoses and drug use...
July 1, 2017: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/28697424/peak-exposures-to-main-components-of-ash-and-gaseous-diesel-exhausts-in-closed-and-open-ash-loading-stations-at-biomass-fuelled-power-plants
#2
Juha Laitinen, Hanna Koponen, Olli Sippula, Kirsi Korpijärvi, Mika Jumpponen, Sirpa Laitinen, Marjaleena Aatamila, Jarkko Tissari, Tommi Karhunen, Kari Ojanen, Jorma Jokiniemi, Leena Korpinen
Fly and bottom ashes are collected at power plants to reduce the environmental effects of energy production. However, handling the ashes causes health problems for operators, maintenance workers and truck drivers at the power plants. Hence, we evaluated ash loaders' peak inhalation exposures to the chemical components of ash and diesel exhausts in open and closed ash loading stations at biomass-fuelled combined heat and power plants. We also carried out chemical and morphological analyses of the ashes to evaluate their health hazard potential in order to find practical technical measures to reduce workers' exposure...
July 4, 2017: Chemosphere
https://www.readbyqxmd.com/read/28695906/no-association-between-proton-pump-inhibitor-use-and-risk-of-alzheimer-s-disease
#3
Heidi Taipale, Anna-Maija Tolppanen, Miia Tiihonen, Antti Tanskanen, Jari Tiihonen, Sirpa Hartikainen
OBJECTIVES: The objective of the study was to investigate whether proton pump inhibitor (PPI) use is associated with an increased risk of clinically verified Alzheimer's disease (AD). METHODS: A Finnish nationwide nested case-control study MEDALZ includes all community-dwelling individuals with newly diagnosed AD during 2005-2011 (N=70,718), and up to four age-, sex-, and region of residence-matched comparison individuals for each case (N=282,858). Data were extracted from Finnish nationwide health-care registers...
July 11, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28682476/plasma-levels-of-hgf-and-plgf-predict-mortality-in-a-general-population-a-prospective-cohort-study
#4
Kristiina Santalahti, Aki Havulinna, Mikael Maksimow, Tanja Zeller, Stefan Blankenberg, Aki Vehtari, Heikki Joensuu, Sirpa Jalkanen, Veikko Salomaa, Marko Salmi
BACKGROUND: Circulating levels of growth factors involved in leukocyte production and angiogenesis could be indicative of underlying aberrations of tissue homeostasis and therefore be utilized as predictors of risk for all-cause cardiovascular disease (CVD) or cancer mortality. METHODS: Baseline plasma levels of a range of growth factors were measured in two cohorts of the population-based FINRISK study (1997 Discovery cohort, N=8444, aged 25-74; 2002 Replication cohort, N=2951, aged 51-74 years) using a multiplexed bead array methodology and ELISA...
July 6, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28679932/the-guiding-role-of-a-paradigm-in-informatics-education-and-research
#5
Kaija Saranto, Ulla-Mari Kinnunen, Eija Kivekäs, Juhamatti Huusko, Sirpa Kuusisto-Niemi
This study presents the current status of a paradigm used in informatics education and research in the health and human services fields. The aim is to synthesize the research focuses of students' theses and evaluate the current situation. The paradigm models informatics research. The research focus, questions and applied research methods were coded for 144 Master's degree theses. Based on the results, the theses could easily be coded for the paradigm concepts and research focuses. The most often used concept was data, which was connected to steering and organizing information management in work processes...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28670215/using-scenario-based-training-to-promote-information-literacy-among-on-call-consultant-pediatricians
#6
Jonas Pettersson, Emil Bjorkander, Sirpa Bark, Daniel Holmgren, Per Wekell
BACKGROUND: Traditionally, teaching hospital staff to search for medical information relies heavily on educator-defined search methods. In contrast, the authors describe our experiences using real-time scenarios to teach on-call consultant pediatricians information literacy skills as part of a two-year continuing professional development program. CASE PRESENTATION: Two information-searching workshops were held at Sahlgrenska University Hospital in Gothenburg, Sweden...
July 2017: Journal of the Medical Library Association: JMLA
https://www.readbyqxmd.com/read/28669759/sirpa-inhibited-marrow-derived-macrophages-engorge-accumulate-and-differentiate-in-antibody-targeted-regression-of-solid-tumors
#7
Cory M Alvey, Kyle R Spinler, Jerome Irianto, Charlotte R Pfeifer, Brandon Hayes, Yuntao Xia, Sangkyun Cho, P C P Dave Dingal, Jake Hsu, Lucas Smith, Manu Tewari, Dennis E Discher
Marrow-derived macrophages are highly phagocytic, but whether they can also traffic into solid tumors and engulf cancer cells is questionable, given the well-known limitations of tumor-associated macrophages (TAMs). Here, SIRPα on macrophages from mouse and human marrow was inhibited to block recognition of its ligand, the "marker of self" CD47 on all other cells. These macrophages were then systemically injected into mice with fluorescent human tumors that had been antibody targeted. Within days, the tumors regressed, and single-cell fluorescence analyses showed that the more the macrophages engulfed, the more they accumulated within regressing tumors...
June 21, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28599121/head-or-brain-injuries-and-alzheimer-s-disease-a-nested-case-control-register-study
#8
Anna-Maija Tolppanen, Heidi Taipale, Sirpa Hartikainen
INTRODUCTION: Many previous studies have been limited by self- or proxy-reported injury or short follow-up. We investigated whether head or brain injuries are associated with Alzheimer's disease (AD), possible modifying factors and dose-response relationship. METHODS: Nested register-based case-control study of all community dwellers who received clinically verified AD diagnosis in Finland in 2005 to 2011 (n = 70,719) and one to four matched controls for each case (n of controls = 282,862)...
June 7, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28577224/long-term-use-of-proton-pump-inhibitors-among-community-dwelling-persons-with-and-without-alzheimer-s-disease
#9
Heidi Juntunen, Heidi Taipale, Antti Tanskanen, Anna-Maija Tolppanen, Jari Tiihonen, Sirpa Hartikainen, Miia Tiihonen
PURPOSE: The aim of this study is to determine the prevalence of use and long-term use (≥180 days) of proton pump inhibitors (PPIs) and associated factors among community-dwellers with and without Alzheimer's disease (AD). METHODS: MEDALZ cohort encompassed all persons who received a verified diagnosis of AD in Finland during the years 2005-2011 and their age-, sex-, and region of residence-matched comparison persons, including 69,353 persons with and 69,353 persons without AD...
June 2, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28567538/comparative-effectiveness-of-eight-antiepileptic-drugs-in-adults-with-focal-refractory-epilepsy-the-influence-of-age-gender-and-the-sequence-in-which-drugs-were-introduced-onto-the-market
#10
Jussi Mäkinen, Jukka Peltola, Jani Raitanen, Tiina Alapirtti, Sirpa Rainesalo
The first objective was to determine the long-term retention rate of eight antiepileptic drugs (AEDs) commonly used as adjunctive therapy in adults with focal refractory epilepsy. Second, we assessed the effects of age and gender on retention rates. Third, we examined if the retention rate could be influenced by the sequence in which the AEDs had entered the market. Patients with focal refractory epilepsy treated with any of the eight AEDs in Tampere University Hospital were identified retrospectively (N = 507)...
July 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28556976/exploring-the-radiosynthesis-and-in-vitro-characteristics-of-68-ga-ga-dota-siglec-9
#11
Svend B Jensen, Meeri Käkelä, Lars Jødal, Olli Moisio, Aage K O Alstrup, Sirpa Jalkanen, Anne Roivainen
Vascular adhesion protein 1 is a leukocyte homing-associated glycoprotein, which upon inflammation rapidly translocates from intracellular sources to the endothelial cell surface. It has been discovered that the cyclic peptide residues 283-297 of sialic acid-binding IgG-like lectin 9 (Siglec-9) "CARLSLSWRGLTLCPSK" bind to vascular adhesion protein 1 and hence makes the radioactive analogues of this compound ([(68) Ga]Ga-DOTA-Siglec-9) interesting as a noninvasive visualizing marker of inflammation. Three different approaches to the radiosynthesis of [(68) Ga]Ga-DOTA-Siglec-9 are presented and compared with previously published methods...
May 30, 2017: Journal of Labelled Compounds & Radiopharmaceuticals
https://www.readbyqxmd.com/read/28556934/a-quantitative-systematic-review-of-the-effects-of-training-interventions-on-enhancing-the-competence-of-nursing-staff-in-managing-challenging-patient-behaviour
#12
REVIEW
Sirpa Tölli, Pirjo Partanen, Raija Kontio, Arja Haggman-Laitila
AIMS: This systematic quantitative review identifies and summarizes the current knowledge and effects of training interventions for managing patients' challenging behaviour. BACKGROUND: Challenging behaviour is an acknowledged worldwide healthcare problem and its management can have a huge impact on quality of care. Evidence-based training interventions that focus on managing challenging behaviour are needed, but few tools for the systematic evaluation of these interventions are currently offered...
May 30, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28556303/screening-approach-for-identifying-candidate-drugs-and-drug-drug-interactions-related-to-hip-fracture-risk-in-persons-with-alzheimer-disease
#13
Anna-Maija Tolppanen, Heidi Taipale, Marjaana Koponen, Antti Tanskanen, Piia Lavikainen, Jussi Paananen, Jari Tiihonen, Sirpa Hartikainen
PURPOSE: To assess whether a "drugome-wide" screen with case-crossover design is a feasible approach for identifying candidate drugs and drug-drug interactions. METHODS: All community-dwelling residents of Finland who received a clinically verified Alzheimer disease diagnosis in 2005 to 2011 and experienced incident hip fracture (HF) afterwards (N = 4851). Three scenarios were used to test the sensitivity of this approach (1) hazard period 0 to 30 and control period 31 to 61 days before HF, (2) hazard period 0 to 30 and control period 336 to 366 days before HF, and (3) hazard period 0 to 14 and control period 16 to 30 days before HF...
May 29, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28545141/prion-pathogenesis-is-unaltered-in-the-absence-of-sirp%C3%AE-mediated-don-t-eat-me-signaling
#14
Mario Nuvolone, Marta Paolucci, Silvia Sorce, Veronika Kana, Rita Moos, Takashi Matozaki, Adriano Aguzzi
Prion diseases are neurodegenerative conditions caused by misfolding of the prion protein, leading to conspicuous neuronal loss and intense microgliosis. Recent experimental evidence point towards a protective role of microglia against prion-induced neurodegeneration, possibly through elimination of prion-containing apoptotic bodies. The molecular mechanisms by which microglia recognize and eliminate apoptotic cells in the context of prion diseases are poorly defined. Here we investigated the possible involvement of signal regulatory protein α (SIRPα), a key modulator of host cell phagocytosis; SIRPα is encoded by the Sirpa gene that is genetically linked to the prion gene Prnp...
2017: PloS One
https://www.readbyqxmd.com/read/28537101/clinical-findings-in-25-patients-with-sinonasal-or-nasopharyngeal-extramedullary-plasmacytoma-in-a-four-decade-single-centre-series
#15
Seija Inkeri Vento, Pauli Vähämurto, Kaija Silventoinen, Marja-Liisa Karjalainen-Lindsberg, Susanna Mannisto, Sirpa Leppä, Antti Aarni Mäkitie
OBJECTIVES: Extramedullary plasmacytoma in the sinonasal tract or nasopharynx is rare. The aim of the study was to review data on symptoms, clinical findings, treatment and follow-up of plasmacytomas in the sinonasal and nasopharyngeal regions in order to delineate the main clinical characteristics and the optimal management. METHOD: Twenty-five patients with sinonasal or nasopharyngeal plasmacytoma, diagnosed and treated at the Helsinki University Hospital during a 39-year period from 1975 to 2013 were retrospectively reviewed...
May 24, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28502405/a-practical-guidance-for-assessments-of-sedentary-behavior-at-work-a-perosh-initiative
#16
Andreas Holtermann, Vera Schellewald, Svend Erik Mathiassen, Nidhi Gupta, Andrew Pinder, Anne Punakallio, Kaj Bo Veiersted, Britta Weber, Esa-Pekka Takala, Francesco Draicchio, Henrik Enquist, Kevin Desbrosses, Maria Peñahora García Sanz, Marzena Malińska, María Villar, Michael Wichtl, Michaela Strebl, Mikael Forsman, Sirpa Lusa, Tomasz Tokarski, Peter Hendriksen, Rolf Ellegast
Sedentary behavior is defined as sitting or lying with low energy expenditure. Humans in industrialized societies spend an increasing amount of time in sedentary behaviors every day. This has been associated with detrimental health outcomes. Despite a growing interest in the health effects of sedentary behavior at work, associations remain unclear, plausibly due to poor and diverse methods for assessing sedentary behavior. Thus, good practice guidance for researchers and practitioners on how to assess occupational sedentary behavior are needed...
September 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/28486815/incident-use-of-a-potentially-inappropriate-medication-and-hip-fracture-in-community-dwelling-older-persons-with-alzheimer-s-disease
#17
Virva Hyttinen, Heidi Taipale, Anna-Maija Tolppanen, Antti Tanskanen, Jari Tiihonen, Sirpa Hartikainen, Hannu Valtonen
BACKGROUND: Potentially inappropriate medications (PIMs) increase the risk of adverse drug reactions and events and have been associated with greater health care service use, such as an increased risk of hospitalization. OBJECTIVE: The aim of this study is to evaluate the association between PIM use and hip fractures in a nationwide cohort of community-dwelling persons ≥65 years old with Alzheimer's disease (AD). METHODS: The study, which is based on the Finnish nationwide MEDALZ cohort, included all persons diagnosed with AD between 2005 and 2011 (n = 70 718)...
May 1, 2017: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/28481341/genome-sequencing-and-population-genomic-analyses-provide-insights-into-the-adaptive-landscape-of-silver-birch
#18
Jarkko Salojärvi, Olli-Pekka Smolander, Kaisa Nieminen, Sitaram Rajaraman, Omid Safronov, Pezhman Safdari, Airi Lamminmäki, Juha Immanen, Tianying Lan, Jaakko Tanskanen, Pasi Rastas, Ali Amiryousefi, Balamuralikrishna Jayaprakash, Juhana I Kammonen, Risto Hagqvist, Gugan Eswaran, Viivi Helena Ahonen, Juan Alonso Serra, Fred O Asiegbu, Juan de Dios Barajas-Lopez, Daniel Blande, Olga Blokhina, Tiina Blomster, Suvi Broholm, Mikael Brosché, Fuqiang Cui, Chris Dardick, Sanna E Ehonen, Paula Elomaa, Sacha Escamez, Kurt V Fagerstedt, Hiroaki Fujii, Adrien Gauthier, Peter J Gollan, Pauliina Halimaa, Pekka I Heino, Kristiina Himanen, Courtney Hollender, Saijaliisa Kangasjärvi, Leila Kauppinen, Colin T Kelleher, Sari Kontunen-Soppela, J Patrik Koskinen, Andriy Kovalchuk, Sirpa O Kärenlampi, Anna K Kärkönen, Kean-Jin Lim, Johanna Leppälä, Lee Macpherson, Juha Mikola, Katriina Mouhu, Ari Pekka Mähönen, Ülo Niinemets, Elina Oksanen, Kirk Overmyer, E Tapio Palva, Leila Pazouki, Ville Pennanen, Tuula Puhakainen, Péter Poczai, Boy J H M Possen, Matleena Punkkinen, Moona M Rahikainen, Matti Rousi, Raili Ruonala, Christiaan van der Schoot, Alexey Shapiguzov, Maija Sierla, Timo P Sipilä, Suvi Sutela, Teemu H Teeri, Arja I Tervahauta, Aleksia Vaattovaara, Jorma Vahala, Lidia Vetchinnikova, Annikki Welling, Michael Wrzaczek, Enjun Xu, Lars G Paulin, Alan H Schulman, Martin Lascoux, Victor A Albert, Petri Auvinen, Ykä Helariutta, Jaakko Kangasjärvi
Silver birch (Betula pendula) is a pioneer boreal tree that can be induced to flower within 1 year. Its rapid life cycle, small (440-Mb) genome, and advanced germplasm resources make birch an attractive model for forest biotechnology. We assembled and chromosomally anchored the nuclear genome of an inbred B. pendula individual. Gene duplicates from the paleohexaploid event were enriched for transcriptional regulation, whereas tandem duplicates were overrepresented by environmental responses. Population resequencing of 80 individuals showed effective population size crashes at major points of climatic upheaval...
June 2017: Nature Genetics
https://www.readbyqxmd.com/read/28424246/enteropathy-associated-t-cell-lymphoma-subtypes-are-characterized-by-loss-of-function-of-setd2
#19
Andrea B Moffitt, Sarah L Ondrejka, Matthew McKinney, Rachel E Rempel, John R Goodlad, Chun Huat Teh, Sirpa Leppa, Susanna Mannisto, Panu E Kovanen, Eric Tse, Rex K H Au-Yeung, Yok-Lam Kwong, Gopesh Srivastava, Javeed Iqbal, Jiayu Yu, Kikkeri Naresh, Diego Villa, Randy D Gascoyne, Jonathan Said, Magdalena B Czader, Amy Chadburn, Kristy L Richards, Deepthi Rajagopalan, Nicholas S Davis, Eileen C Smith, Brooke C Palus, Tiffany J Tzeng, Jane A Healy, Patricia L Lugar, Jyotishka Datta, Cassandra Love, Shawn Levy, David B Dunson, Yuan Zhuang, Eric D Hsi, Sandeep S Dave
Enteropathy-associated T cell lymphoma (EATL) is a lethal, and the most common, neoplastic complication of celiac disease. Here, we defined the genetic landscape of EATL through whole-exome sequencing of 69 EATL tumors. SETD2 was the most frequently silenced gene in EATL (32% of cases). The JAK-STAT pathway was the most frequently mutated pathway, with frequent mutations in STAT5B as well as JAK1, JAK3, STAT3, and SOCS1 We also identified mutations in KRAS, TP53, and TERT Type I EATL and type II EATL (monomorphic epitheliotropic intestinal T cell lymphoma) had highly overlapping genetic alterations indicating shared mechanisms underlying their pathogenesis...
May 1, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28415993/moving-to-business-changes-in-physical-activity-and-sedentary-behavior-after-multilevel-intervention-in-small-and-medium-size-workplaces
#20
Minna Aittasalo, Matleena Livson, Sirpa Lusa, Ahti Romo, Henri Vähä-Ypyä, Kari Tokola, Harri Sievänen, Ari Mänttäri, Tommi Vasankari
BACKGROUND: Regular physical activity (PA) promotes and excessive sedentary behavior (SB) deteriorates health. Yet the Finnish working-aged population spends most of the day sitting. A 1-year Moving To Business (MTB) -intervention supported small and medium-size workplaces to combat sedentariness. This paper reports the changes in employees' PA and SB from before MTB (baseline) to 1 year after baseline (follow-up). METHODS: Twelve workplaces with a total of 396 employees participated...
April 17, 2017: BMC Public Health
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