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Lari Lehtovirta, Aleksi Reito, Jyrki Parkkinen, Sirpa Peräniemi, Jouko Vepsäläinen, Antti Eskelinen
Adverse Reaction to Metal Debris (ARMD) is a major cause of implant failure leading to revision surgery in patients with metal-on-metal (MoM) hip arthroplasties. However, the pathogenesis and its association to implant wear are poorly understood and previous studies have yielded discrepant results. We sought to investigate the associations between histological findings, whole blood and synovial fluid metal ion concentrations and periprosthetic tissue metal concentrations in patients with MoM total hip replacements and hip resurfacings revised for ARMD...
2018: PloS One
Oksana Skaldina, Sirpa Peräniemi, Jouni Sorvari
Ants accumulate heavy metals and respond to pollution with modification in species composition, community structure, altered behaviour and immunity. However, the levels of heavy metals in ants' nests and explicit individual-level responses towards heavy metals have not been revealed. We found that red wood ants Formica lugubris accumulate high and correlated values of such heavy metals as Al, Cd, Co, Cu, Fe, Ni, Pb and Zn both in ants and nest material near cobalt smelter in Finland. Relative differences in metal concentrations were higher in nests than in ants...
May 12, 2018: Environmental Pollution
Cindy Audiger, Sylvie Lesage
In contrast to conventional dendritic cells (cDC), when merocytic dendritic cells (mcDC) present antigens derived from apoptotic bodies, T cell anergy is reversed rather than induced, a process that promotes autoimmunity. Interestingly, mcDC are present in higher proportion in type 1 diabetes-prone NOD mice than in autoimmune-resistant B6 and BALB/c mice, and the Insulin-dependent diabetes 13 locus is linked to mcDC proportion. Therefore, mcDC are notably associated with susceptibility to autoimmune diabetes...
May 13, 2018: Immunology and Cell Biology
Tapani Tuomi, Markku Linnainmaa, Sirpa Pennanen
To reduce the incidence of occupational diseases related to exposure to respirable silica at work, the main industries in the EU associated with respirable silica agreed on measures to improve working conditions through the application of good practices. These practices were included in “The Agreement on Workers Health Protection through the Good Handling and Use of Crystalline Silica and Products Containing it” (NEPSI agreement), signed in April 2006. In Finland, we have previously seen a decline in exposure to respirable quartz in relevant industries upon the treaty coming into effect, during the years 2006⁻2013...
May 3, 2018: International Journal of Environmental Research and Public Health
Toni Kulju, Joonas Haapasalo, Kai Lehtimäki, Sirpa Rainesalo, Jukka Peltola
OBJECTIVES: Neurostimulation has offered new treatment options in refractory epilepsy, first with vagus nerve stimulation (VNS) and more recently with deep brain stimulation (DBS). There is a lack of previous detailed data assessing the relationship between VNS and ANT-DBS. The aim of this study was to investigate the potential correlation between therapeutic responses to VNS and ANT-DBS. MATERIALS AND METHODS: A total of 11 patients with previous VNS therapy underwent ANT-DBS implantation...
May 8, 2018: Brain and Behavior
Anu Mikkonen, Tao Li, Mari Vesala, Jatta Saarenheimo, Viivi Ahonen, Sirpa Kärenlampi, James D Blande, Marja Tiirola, Arja Tervahauta
Botanical air filtration is a promising technology for reducing indoor air contaminants, but the underlying mechanisms need better understanding. Here, we made a set of chamber fumigation experiments of up to 16 weeks duration, to study the filtration efficiencies for seven volatile organic compounds (VOCs; decane, toluene, 2-ethylhexanol, α-pinene, octane, benzene, xylene) and to monitor microbial dynamics in simulated green wall systems. Biofiltration functioned on sub-ppm VOC levels without concentration-dependence...
May 6, 2018: Indoor Air
Petri Elo, Sina Tadayon, Heidi Liljenbäck, Jarmo Teuho, Meeri Käkelä, Kalle Koskensalo, Virva Saunavaara, Jenni Virta, Tibor Z Veres, Aida Kiviniemi, Antti Saraste, Päivi Marjamäki, Laura Airas, Sirpa Jalkanen, Anne Roivainen
BACKGROUND: Vascular adhesion protein-1 (VAP-1) is an inflammation-inducible endothelial cell molecule and primary amine oxidase that mediates leukocyte entry to sites of inflammation. However, there is limited knowledge of the inflammation-related expression of VAP-1 in the central nervous system (CNS). Therefore, we investigated the expression of VAP-1 within the CNS vasculature in two focal rat models of experimental autoimmune encephalomyelitis (EAE) mimicking multiple sclerosis (MS)...
May 1, 2018: Journal of Neuroinflammation
Juhani Multanen, Arja Häkkinen, Pauli Heikkinen, Hannu Kautiainen, Sirpa Mustalampi, Jari Ylinen
Low-energy pulsed electromagnetic field (PEMF) therapy has been suggested as a promising therapy to increase microcirculation, which is of great concern in patients with fibromyalgia. This study evaluated the effectiveness of PEMF therapy on the treatment of fibromyalgia. A group of 108 women with fibromyalgia were allocated to a 12-week treatment period with an active Bio-Electro-Magnetic-Energy-Regulation (BEMER) device and a similar treatment period with an inactive device. Each patient received active and sham treatments in a random order...
April 30, 2018: Bioelectromagnetics
Sirpa Manderoos, Mariitta Vaara, Sirkka-Liisa Karppi, Sirkka Aunola, Pauli Puukka, Jukka Surakka, Esko Mälkiä
OBJECTIVE: The purpose of this cross-sectional study was to determine the relationships between agility, running speed, jumping height and length, body mass index, self-report pain in back and in lower extremities, personal factors as self-report health and fitness, and leisure time physical activity in physically inactive or active adult people. METHODS: Altogether, 233 healthy subjects, 149 women (43.0 ± 7.3 years) and 84 men (44.0 ± 7.7 years), participated into study...
April 26, 2018: Physiotherapy Research International: the Journal for Researchers and Clinicians in Physical Therapy
Juho Jalkanen, Olli Hautero, Mikael Maksimow, Sirpa Jalkanen, Harri Hakovirta
INTRODUCTION: The aim of the present study was to assess the circulating levels of vascular endothelial growth factor (VEGF) and other suggested therapeutic growth factors with the degree of ischemia in patients with different clinical manifestations of peripheral arterial disease (PAD) according to the Rutherford grades. METHODS: The study cohort consists of 226 consecutive patients admitted to a Department of Vascular Surgery for elective invasive procedures. PAD patients were grouped according to the Rutherford grades after a clinical assessment...
April 21, 2018: Cytokine
Mika Nieminen, Sirpa Piirainen, Ulf Sikström, Stefan Löfgren, Hannu Marttila, Sakari Sarkkola, Ari Laurén, Leena Finér
The objective of this study was to evaluate the potential of different water management options to mitigate sediment and nutrient exports from ditch network maintenance (DNM) areas in boreal peatland forests. Available literature was reviewed, past data reanalyzed, effects of drainage intensity modeled, and major research gaps identified. The results indicate that excess downstream loads may be difficult to prevent. Water protection structures constructed to capture eroded matter are either inefficient (sedimentation ponds) or difficult to apply (wetland buffers)...
March 27, 2018: Ambio
Heidi Taipale, Willy Gomm, Karl Broich, Wolfgang Maier, Anna-Maija Tolppanen, Antti Tanskanen, Jari Tiihonen, Sirpa Hartikainen, Britta Haenisch
OBJECTIVES: To evaluate the association between regular antiepileptic drug (AED) use and incident dementia. DESIGN: Case-control analysis. SETTING: Finnish public health register and German health insurance data. PARTICIPANTS: Individuals with dementia of any type (German data, N=20,325) and Alzheimer's disease (AD; Finnish data, N=70,718) were matched with up to four control persons without dementia. MEASUREMENTS: We analyzed the association between regular AED use and dementia...
March 22, 2018: Journal of the American Geriatrics Society
Aleksi Hamina, Piia Lavikainen, Antti Tanskanen, Anna-Maija Tolppanen, Jari Tiihonen, Sirpa Hartikainen, Heidi Taipale
BACKGROUND: We analyzed the impact of opioid initiation on the prevalence of antipsychotic and benzodiazepine and related drug (BZDR) use among community-dwelling persons with Alzheimer's disease (AD). METHODS: We utilized the register-based Medication use and Alzheimer's disease (MEDALZ) cohort for this study. We included all community-dwelling persons diagnosed with AD during 2010-2011 in Finland initiating opioid use (n = 3,327) and a matched cohort of persons not initiating opioids (n = 3,325)...
March 21, 2018: International Psychogeriatrics
Erika Gucciardo, Sirpa Loukovaara, Ani Korhonen, Pauliina Repo, Beatriz Martins, Helena Vihinen, Eija Jokitalo, Kaisa Lehti
Proliferative diabetic retinopathy (PDR) is a major diabetic microvascular complication characterized by pathological angiogenesis. Several retinopathy animal models have been developed to study the disease mechanisms and putative targets. However, knowledge on the human proliferative disease remains incomplete, relying on steady-state results from thin histological neovascular tissue sections and vitreous samples. New translational models are thus required to comprehensively understand the disease pathophysiology and develop improved therapeutic interventions...
June 2018: Journal of Pathology
Tommi Nora, Hanna Heinonen, Mirja Tenhunen, Sirpa Rainesalo, Soila Järvenpää, Kai Lehtimäki, Jukka Peltola
Deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) is a method of neuromodulation used for refractory focal epilepsy. We report a patient suffering from drug-resistant epilepsy who developed novel visual symptoms and atypical seizures with the onset of ANT-DBS therapy. Rechallenge under video electroencephalography recording confirmed that lowering the stimulation voltage alleviated these symptoms. Subsequent stimulation with the initial voltage value did not cause the recurrence of either the visual symptoms or the new seizure type, and appeared to alleviate the patient's seizures in long-term follow-up...
2018: Frontiers in Neurology
Karolina Losenkova, Mariachiara Zuccarini, Mikko Helenius, Guillaume Jacquemet, Evgenia Gerasimovskaya, Camilla Tallgren, Sirpa Jalkanen, Gennady G Yegutkin
Intravascular ATP and adenosine have emerged as important regulators of endothelial barrier function, vascular remodeling and neovascularization at various pathological states, including hypoxia, inflammation and oxidative stress. By using human umbilical vein endothelial cells (HUVEC) and bovine vasa vasorum endothelial cells (VVEC) as representatives of macro- and microvessel phenotypes, this study was undertaken to evaluate cellular mechanisms contributing to physiological adaptation of vascular endothelium to hypoxia, with a particular emphasis on ectoenzymatic purine-converting activities and their link to intracellular ATP homeostasis and signaling pathways...
May 2018: Biochimica et Biophysica Acta
Cecilia Hagert, Outi Sareila, Tiina Kelkka, Kutty Selva Nandakumar, Mattias Collin, Bingze Xu, Simon Guérard, Johan Bäcklund, Sirpa Jalkanen, Rikard Holmdahl
OBJECTIVE: To develop a new chronic RA model which is driven by the innate immune system. METHOD: The injection of a cocktail of four monoclonal antibodies against collagen type II followed by intra-peritoneal injections of mannan (from Saccharomyces cerevisiae) on days 5 and 60 led to the development of chronic arthritis in B10.Q mice. The role of the innate versus the adaptive immune system in this arthritis model was investigated using genetically modified mouse strains...
March 7, 2018: Arthritis & Rheumatology
Cecilia Hagert, Outi Sareila, Tiina Kelkka, Sirpa Jalkanen, Rikard Holmdahl
The injection of mannan into mice can result in the development of psoriasis (Ps) and psoriatic arthritis (PsA), whereas co-injection with antibodies toward collagen type II leads to a chronic rheumatoid-like arthritis. The critical event in all these diseases is mannan-mediated activation of macrophages, causing more severe disease if the macrophages are deficient in neutrophil cytosolic factor 1 (Ncf1), i.e., lack the capacity to make a reactive oxygen species (ROS) burst. In this study, we investigated the role of one of the receptors binding mannan; the macrophage mannose receptor (MR, CD206)...
2018: Frontiers in Immunology
Datu Respatika, Yasuyuki Saito, Ken Washio, Satomi Komori, Takenori Kotani, Hideki Okazawa, Yoji Murata, Takashi Matozaki
Signal regulatory protein α (SIRPα), is an immunoglobulin superfamily protein that is predominantly expressed in macrophages and dendritic cells (DCs), especially CD4+ conventional DCs (cDCs). In this study, we demonstrated that, in addition to the reduced number of CD4+ cDCs, the number of T cells was significantly decreased in the spleen of Sirpa-/- mice, in which full-length of SIRPα protein was systemically ablated. The size of the T cell zone was markedly reduced in the spleen of Sirpa-/- mice. In addition, Sirpa-/- mice revealed a marked reduction of CCL19, CCL21, and IL-7 expression, which are thought to be important for homeostasis of T cells in the spleen...
August 10, 2017: Kobe Journal of Medical Sciences
Sirpa Pirilä, Paula Pirilä, Terhi Ansamaa, Anneli Yliherva, Samuel Sonning, Leena Rantala
OBJECTIVE: Our interest was in how teachers' voices behave during the delivery of lessons in core subjects (e.g., mathematics, science, etc.). We sought to evaluate the relationship between voice sound pressure level (SPL), vocal fundamental frequency (F0), voice symptoms, activity noise, and differences therein during the first and the last lessons in core subjects of the day. PATIENTS AND METHODS: The participants were 24 female elementary school teachers. Voice symptoms were evaluated by questionnaire...
2017: Folia Phoniatrica et Logopaedica
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