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https://www.readbyqxmd.com/read/27911327/anticholinergic-exposure-and-risk-of-pneumonia-in-persons-with-alzheimer-s-disease-a-nested-case-control-study
#1
Pasi Lampela, Anna-Maija Tolppanen, Antti Tanskanen, Jari Tiihonen, Sirpa Hartikainen, Heidi Taipale
BACKGROUND: Risk of pneumonia is increased in persons with Alzheimer's disease (AD). In some studies, anticholinergic drugs (AC) have been associated with an increased pneumonia risk. OBJECTIVE: We analyzed the risk of pneumonia associated with ACs in persons with AD. METHODS: We performed a nested case-control study using register-based data from a Finnish nationwide MEDALZ cohort including all community-dwelling persons diagnosed with AD during 2005-2011...
November 28, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27910133/physical-restraints-and-associations-with-neuropsychiatric-symptoms-and-personal-characteristics-in-residential-care-a-cross-sectional-study
#2
Marja Kuronen, Hannu Kautiainen, Pertti Karppi, Sirpa Hartikainen, Hannu Koponen
BACKGROUND: Physical restraints are widely used in residential care. The objective was to investigate restraint use and its associations with neuropsychiatric symptoms and personal characteristics in residential care. METHODS: Data were collected in the South Savo Hospital District from 66 of 68 public or private institutions providing long-term residential care. Nurses assessed the use of physical restraints and neuropsychiatric symptoms (NPS) included in the symptom list of the Neuropsychiatric Inventory (NPI)...
December 2, 2016: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/27908278/comparison-of-predictors-of-hip-fracture-and-mortality-after-hip-fracture-in-community-dwellers-with-and-without-alzheimer-s-disease-exposure-matched-cohort-study
#3
Anna-Maija Tolppanen, Heidi Taipale, Antti Tanskanen, Jari Tiihonen, Sirpa Hartikainen
BACKGROUND: Dementia, with Alzheimer's disease (AD) being the most common form, is a major hip fracture risk factor, but currently it is not known whether the same factors predict hip fracture among persons with and without dementia/AD. We compared the predictors of hip fracture and mortality after hip fracture in persons with and without AD. METHODS: An exposure-matched cohort of all community-dwellers of Finland who received a new clinically verified AD diagnosis in 2005-2011 and had no history of previous hip fracture (N = 67,072) and an age, sex, and region-matched cohort of persons without AD (N = 67,072)...
December 1, 2016: BMC Geriatrics
https://www.readbyqxmd.com/read/27903737/allergen-induced-cd4-t-cell-cytokine-production-within-airway-mucosal-dendritic-cell-t-cell-clusters-drives-the-local-recruitment-of-myeloid-effector-cells
#4
Tibor Z Veres, Tamás Kopcsányi, Nicholas van Panhuys, Michael Y Gerner, Zhiduo Liu, Pia Rantakari, Johannes Dunkel, Masayuki Miyasaka, Marko Salmi, Sirpa Jalkanen, Ronald N Germain
Allergic asthma develops in the mucosal tissue of small bronchi. At these sites, local cytokine production by Th2/Th17 cells is believed to be critical for the development of tissue eosinophilia/neutrophilia. Using the mouse trachea as a relevant model of human small airways, we performed advanced in vivo dynamic and in situ static imaging to visualize individual cytokine-producing T cells in the airway mucosa and to define their immediate cellular environment. Upon allergen sensitization, newly recruited CD4(+) T cells formed discrete Ag-driven clusters with dendritic cells (DCs)...
November 30, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27900169/neuromuscular-exercise-and-back-counselling-for-female-nursing-personnel-with-recurrent-non-specific-low-back-pain-study-protocol-of-a-randomised-controlled-trial-nurse-rct
#5
Jaana H Suni, Marjo Rinne, Markku Kankaanpää, Annika Taulaniemi, Sirpa Lusa, Harri Lindholm, Jari Parkkari
INTRODUCTION: Nursing personnel have high risk for incidence of low back pain (LBP) followed by development of chronic pain and disability. Multiple risk factors such as patient handling, night shift work and lack of supporting work culture have been identified. In subacute LBP, high-fear avoidance is prognostic for more pain, disability and not returning to work. Lack of leisure-time physical activity predicts long-term sickness absence. The purpose of this study is to compare effectiveness of 6-month neuromuscular exercise and counselling in treating back pain in female nursing personnel with recurrent non-specific LBP pain compared with either (exercise or counselling) alone and a non-treatment control group...
2016: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/27896799/a-comparison-of-sex-differences-in-psychotropic-medication-use-in-older-people-with-alzheimer-s-disease-in-the-us-and-finland
#6
Daniela C Moga, Heidi Taipale, Anna-Maija Tolppanen, Antti Tanskanen, Jari Tiihonen, Sirpa Hartikainen, Qishan Wu, Gregory A Jicha, Danijela Gnjidic
AIMS: Given the high prevalence of psychotropic medication use in people with dementia and the potential for different prescribing practices in men and women, our study aimed to investigate sex differences in psychotropic medication use in older adults with Alzheimer's disease (AD) living in the US and Finland. METHODS: We used data collected between 2005 and 2011 as part of the National Alzheimer's Coordinating Center (NACC) in the US, and Medication use and Alzheimer's disease (MEDALZ) cohorts in Finland...
November 28, 2016: Drugs & Aging
https://www.readbyqxmd.com/read/27893774/multivalent-interactions-of-human-primary-amine-oxidase-with-the-v-and-c22-domains-of-sialic-acid-binding-immunoglobulin-like-lectin-9-regulate-its-binding-and-amine-oxidase-activity
#7
Heli Elovaara, Vimal Parkash, Ruth Fair-Mäkelä, Outi M H Salo-Ahen, Gabriela Guédez, Eva Bligt-Lindén, Janne Grönholm, Sirpa Jalkanen, Tiina A Salminen
Sialic acid-binding immunoglobulin-like lectin-9 (Siglec-9) on leukocyte surface is a counter-receptor for endothelial cell surface adhesin, human primary amine oxidase (hAOC3), a target protein for anti-inflammatory agents. This interaction can be used to detect inflammation and cancer in vivo, since the labeled peptides derived from the second C2 domain (C22) of Siglec-9 specifically bind to the inflammation-inducible hAOC3. As limited knowledge on the interaction between Siglec-9 and hAOC3 has hampered both hAOC3-targeted drug design and in vivo imaging applications, we have now produced and purified the extracellular region of Siglec-9 (Siglec-9-EC) consisting of the V, C21 and C22 domains, modeled its 3D structure and characterized the hAOC3-Siglec-9 interactions using biophysical methods and activity/inhibition assays...
2016: PloS One
https://www.readbyqxmd.com/read/27877175/thymocytes-in-lyve1-cre-s1pr1-f-f-mice-accumulate-in-the-thymus-due-to-cell-intrinsic-loss-of-sphingosine-1-phosphate-receptor-expression
#8
Akira Takeda, Mohammad Shahadat Hossain, Pia Rantakari, Szandor Simmons, Naoko Sasaki, Marko Salmi, Sirpa Jalkanen, Masayuki Miyasaka
T cell emigration from the thymus is essential for immunological homeostasis. While stromal cell-produced sphingosine-1-phosphate (S1P) has been shown to promote thymocyte egress via the S1P receptor, S1PR1, the significance of S1P/S1PR1 signaling in the thymic stromal cells that surround T cells remains unclear. To address this issue, we developed conditional knockout mice (Lyve1-CRE/S1pr1(f/f) mice) in which S1pr1 was selectively targeted in cells expressing the lymphatic endothelial cell marker, Lyve1. In these mice, T cells were significantly reduced in secondary lymphoid tissues, and CD62L(+) mature CD4 and CD8 single-positive (SP) T cells accumulated in the medulla failed to undergo thymus egress...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27847263/risk-of-hip-fracture-in-benzodiazepine-users-with-and-without-alzheimer-disease
#9
Laura Saarelainen, Anna-Maija Tolppanen, Marjaana Koponen, Antti Tanskanen, Reijo Sund, Jari Tiihonen, Sirpa Hartikainen, Heidi Taipale
OBJECTIVES: To investigate the association between benzodiazepine and related drug (BZDR) use and hip fracture as well as postfracture mortality and duration of hospital stay in community-dwellers with and without Alzheimer disease (AD). DESIGN: Retrospective cohort study. SETTING: The register-based Medication Use and Alzheimer's disease (MEDALZ) study, including all community-dwelling persons diagnosed with AD in Finland during 2005-2011 (n = 70,718) and their matched comparison persons without AD...
November 12, 2016: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/27832456/regulation-of-cd73-in-the-development-of-lower-limb-atherosclerosis
#10
Juho Jalkanen, Maija Hollmén, Sirpa Jalkanen, Harri Hakovirta
Atherosclerosis is an inflammatory process of the arterial wall. CD73 (also known as ecto-5'-nucleotidase) is a key regulator of cell signaling in response to inflammation and hypoxia, and may be important in the development of atherosclerosis. Recently, we have shown that high CD73 activity can be detected in the serum of patients with peripheral arterial disease (PAD). Using this same PAD patient cohort of 226 subjects with 38 femoral artery samples obtained during surgical endarcterectomy and control artery samples taken during autopsy, we explored the association of serum CD73 activity with overall atherosclerotic burden and the expression of CD73 in mature and developing plaques...
November 10, 2016: Purinergic Signalling
https://www.readbyqxmd.com/read/27831963/long-term-use-of-opioids-for-non-malignant-pain-among-community-dwelling-persons-with-and-without-alzheimer-s-disease-in-finland-a-nationwide-register-based-study
#11
Aleksi Hamina, Heidi Taipale, Antti Tanskanen, Anna-Maija Tolppanen, Niina Karttunen, Liisa Pylkkänen, Jari Tiihonen, Sirpa Hartikainen
Persons with Alzheimer's disease (AD) commonly present with chronic non-malignant pain, but long-term use of opioids among this population has not been studied previously. Our aim was to investigate the prevalence of long-term (≥180 days) use of opioids for non-malignant pain and associated factors among community-dwelling persons with AD and to compare the prevalence to a matched cohort without AD.Medication use and Alzheimer's disease (MEDALZ) cohort was utilized for this study, comprising all community-dwelling persons diagnosed with AD in Finland during 2005-2011 and their matched comparison persons without AD...
November 4, 2016: Pain
https://www.readbyqxmd.com/read/27821017/teaching-gerontology-in-globalized-academics-a-qualitative-study-of-thai-nursing-students-views-on-ageing-when-studying-abroad
#12
Karin Mattsson, Sirpa Pietilä Rosendahl
BACKGROUND: Negative views towards ageing and older adults may be a reason why nurses do not choose to work in gerontological nursing. Studying in another cultural context can challenge these views. The Objective was to explore nursing students' views on ageing and older adults before and after a gerontology course held abroad. DESIGN AND METHOD: A qualitative approach based on content analysis of responses to open-ended questions by 30 Thai nursing students studying a gerontology course in Sweden...
November 20, 2016: Contemporary Nurse
https://www.readbyqxmd.com/read/27814547/spatial-variability-of-mercury-and-polyunsaturated-fatty-acids-in-the-european-perch-perca-fluviatilis-implications-for-risk-benefit-analyses-of-fish-consumption
#13
Ursula Strandberg, Marjo Palviainen, Aslak Eronen, Sirpa Piirainen, Ari Laurén, Jarkko Akkanen, Paula Kankaala
This study evaluated the spatial variability of risks and benefits of consuming fish from humic and clear lakes. Mercury in fish is a potential risk for human health, but risk assessment may be confounded by selenium, which has been suggested to counterbalance mercury toxicity. In addition to the risks, fish are also rich in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which are known to be beneficial for cardiovascular health and brain cognitive function in humans. We found that the concentrations of EPA + DHA and mercury in European perch (Perca fluviatilis) vary spatially and are connected with lake water chemistry and catchment characteristics...
October 28, 2016: Environmental Pollution
https://www.readbyqxmd.com/read/27797984/effect-of-characteristics-of-women-on-attendance-in-blind-and-non-blind-randomised-trials-analysis-of-recruitment-data-from-the-epht-trial
#14
Piret Veerus, Krista Fischer, Elina Hemminki, Sirpa-Liisa Hovi, Matti Hakama
OBJECTIVES: To analyse the effect of women's characteristics on their willingness to join a blind or a non-blind subtrial or to be excluded by physicians. DESIGN: Primary prevention trial of postmenopausal hormone therapy (HT). A 2×2, randomised design with a non-blind HT arm or control arm and a blind HT arm or placebo arm. SETTING: 3 clinical centres in Estonia. METHODS: Interest in joining the trial was asked in a questionnaire together with demographic and health status data...
October 18, 2016: BMJ Open
https://www.readbyqxmd.com/read/27794108/fgf21-is-a-biomarker-for-mitochondrial-translation-and-mtdna-maintenance-disorders
#15
Jenni M Lehtonen, Saara Forsström, Emanuela Bottani, Carlo Viscomi, Olivier R Baris, Helena Isoniemi, Krister Höckerstedt, Pia Österlund, Mikko Hurme, Juulia Jylhävä, Sirpa Leppä, Ritva Markkula, Tiina Heliö, Giuliana Mombelli, Johanna Uusimaa, Reijo Laaksonen, Hannu Laaksovirta, Mari Auranen, Massimo Zeviani, Jan Smeitink, Rudolf J Wiesner, Kazuto Nakada, Pirjo Isohanni, Anu Suomalainen
OBJECTIVE: To validate new mitochondrial myopathy serum biomarkers for diagnostic use. METHODS: We analyzed serum FGF21 (S-FGF21) and GDF15 from patients with (1) mitochondrial diseases and (2) nonmitochondrial disorders partially overlapping with mitochondrial disorder phenotypes. We (3) did a meta-analysis of S-FGF21 in mitochondrial disease and (4) analyzed S-Fgf21 and skeletal muscle Fgf21 expression in 6 mouse models with different muscle-manifesting mitochondrial dysfunctions...
October 28, 2016: Neurology
https://www.readbyqxmd.com/read/27786552/use-of-antidementia-drugs-and-risk-of-pneumonia-in-older-persons-with-alzheimer-s-disease
#16
Pasi Lampela, Anna-Maija Tolppanen, Antti Tanskanen, Jari Tiihonen, Piia Lavikainen, Sirpa Hartikainen, Heidi Taipale
INTRODUCTION: Persons with Alzheimer's disease are at an increased risk of pneumonia, but the comparative risks during specific antidementia treatments are not known. We compared the risk of pneumonia in use of donepezil, rivastigmine (oral, transdermal), galantamine and memantine. PATIENTS AND METHODS: We used data from a nationwide cohort of community-dwelling individuals diagnosed with Alzheimer's disease during 2005-2011 in Finland, who initiated monotherapy with acetylcholinesterase inhibitor or memantine (n = 65481)...
October 27, 2016: Annals of Medicine
https://www.readbyqxmd.com/read/27785101/agreement-between-pre2dup-register-data-modeling-method-and-comprehensive-drug-use-interview-among-older-persons
#17
Heidi Taipale, Antti Tanskanen, Marjaana Koponen, Anna-Maija Tolppanen, Jari Tiihonen, Sirpa Hartikainen
BACKGROUND: PRE2DUP is a modeling method that generates drug use periods (ie, when drug use started and ended) from drug purchases recorded in dispensing-based register data. It is based on the evaluation of personal drug purchasing patterns and considers hospital stays, possible stockpiling of drugs, and package information. OBJECTIVE: The objective of this study was to investigate person-level agreement between self-reported drug use in the interview and drug use modeled from dispensing data with PRE2DUP method for various drug classes used by older persons...
2016: Clinical Epidemiology
https://www.readbyqxmd.com/read/27770554/human-liver-sinusoidal-endothelial-cells-promote-intracellular-crawling-of-lymphocytes-during-recruitment-a-new-step-in-migration
#18
Daniel A Patten, Garrick K Wilson, Dalan Bailey, Robert K Shaw, Sirpa Jalkanen, Marko Salmi, Antal Rot, Christopher J Weston, David H Adams, Shishir Shetty
: The recruitment of lymphocytes via the hepatic sinusoidal channels and positioning within liver tissue is a critical event in the development and persistence of chronic inflammatory liver diseases. The hepatic sinusoid is a unique vascular bed lined by hepatic sinusoidal endothelial cells (HSEC), a functionally and phenotypically distinct sub-population of endothelial cells. Using flow based adhesion assays to study the migration of lymphocytes across primary human HSEC, we found that lymphocytes enter into HSEC, confirmed by electron microscopy demonstrating clear intracellular localization of lymphocytes in vitro and by studies in human liver tissues...
October 22, 2016: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/27732656/soluble-cd73-in-critically-ill-septic-patients-data-from-the-prospective-finnaki-study
#19
Suvi T Vaara, Maija Hollmén, Anna-Maija Korhonen, Mikael Maksimow, Tero Ala-Kokko, Marko Salmi, Sirpa Jalkanen, Ville Pettilä
BACKGROUND: CD73 dephosphorylates adenosine monophosphate to adenosine that is an anti-inflammatory molecule inhibiting immune activation and vascular leakage. Therefore, CD73 could be an interesting mediator both in sepsis and acute kidney injury (AKI). We aimed to explore the soluble CD73 (sCD73) levels and their evolution in critically ill patients with severe sepsis and, second, to scrutinize the potential association of sCD73 levels with AKI and 90-day mortality. METHODS: This was a post-hoc laboratory analysis of the prospective, observational FINNAKI study conducted in 17 Finnish ICU during 5 months in 2011-2012...
2016: PloS One
https://www.readbyqxmd.com/read/27731409/leukocyte-trafficking-associated-vascular-adhesion-protein-1-is-expressed-and-functionally-active-in-atherosclerotic-plaques
#20
Johanna M U Silvola, Helena Virtanen, Riikka Siitonen, Sanna Hellberg, Heidi Liljenbäck, Olli Metsälä, Mia Ståhle, Tiina Saanijoki, Meeri Käkelä, Harri Hakovirta, Seppo Ylä-Herttuala, Pekka Saukko, Matti Jauhiainen, Tibor Z Veres, Sirpa Jalkanen, Juhani Knuuti, Antti Saraste, Anne Roivainen
Given the important role of inflammation and the potential association of the leukocyte trafficking-associated adhesion molecule vascular adhesion protein 1 (VAP-1) with atherosclerosis, this study examined whether functional VAP-1 is expressed in atherosclerotic lesions and, if so, whether it could be targeted by positron emission tomography (PET). First, immunohistochemistry revealed that VAP-1 localized to endothelial cells of intra-plaque neovessels in human carotid endarterectomy samples from patients with recent ischemic symptoms...
October 12, 2016: Scientific Reports
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