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https://www.readbyqxmd.com/read/29338115/statin-use-and-vitreoretinal-surgery-findings-from-a-finnish-population-based-cohort-study
#1
Sirpa Loukovaara, Sari Sahanne, Annika Takala, Jari Haukka
PURPOSE: Vitreoretinal (VR) surgery is the third most common intraocular surgery after refractive and cataract surgery. The impact of statin therapy on VR surgery outcomes remains unclear, despite a potentially beneficial effect. We explored the association of preoperative statin therapy and the need for revitrectomy after primary vitrectomy. METHODS: Our historical, population-based, register-based, VR surgery cohort consisted of 5709 patients operated in a tertiary, academic referral hospital in Finland, during 2008-2014, covering 6...
January 16, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29330544/perceptions-of-legislation-relating-to-the-sharing-of-genomic-biobank-results-with-donors-a-survey-of-bbmri-eric-biobanks
#2
Minna Brunfeldt, Harriet Teare, Sirpa Soini, Helena Kääriäinen
Biobanks accumulate huge amounts of research findings, including participants' genomic data. Increasingly this leads to biobanks receiving research results that could be of clinical significance to biobank participants. The EU Horizon 2020 Project 'Genetics Clinic of the Future' surveyed European biobanks' perceptions of the legal and regulatory requirements for communicating individual research results to donors. The goal was to gain background knowledge for possible future guidelines, especially relating to the consent process...
January 12, 2018: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/29320341/long-term-weight-maintenance-after-successful-weight-loss-motivational-factors-support-difficulties-and-success-factors
#3
Sirpa Soini, Pertti Mustajoki, Johan G Eriksson
OBJECTIVES: The main aims of this study were to assess motivational factors for weight loss, and support and difficulties during the weight loss and weight maintenance phase. METHODS: This study was based upon findings from the Finnish Weight Control Registry (FWCR), including 158 formerly obese persons, who lost at least 10% of their initial weight and maintained it for at least 2 years. Data have been collected through electronic forms. RESULTS: The 2 most commonly reported motivational factors for weight loss were health- and appearance-related factors...
January 1, 2018: American Journal of Health Behavior
https://www.readbyqxmd.com/read/29242506/micrornas-regulate-key-cell-survival-pathways-and-mediate-chemosensitivity-during-progression-of-diffuse-large-b-cell-lymphoma
#4
Suvi-Katri Leivonen, Katherine Icay, Kirsi Jäntti, Ilari Siren, Chengyu Liu, Amjad Alkodsi, Alejandra Cervera, Maja Ludvigsen, Stephen Jacques Hamilton-Dutoit, Francesco d'Amore, Marja-Liisa Karjalainen-Lindsberg, Jan Delabie, Harald Holte, Rainer Lehtonen, Sampsa Hautaniemi, Sirpa Leppä
Despite better therapeutic options and improved survival of diffuse large B-cell lymphoma (DLBCL), 30-40% of the patients experience relapse or have primary refractory disease with a dismal prognosis. To identify biological correlates for treatment resistance, we profiled microRNAs (miRNAs) of matched primary and relapsed DLBCL by next-generation sequencing. Altogether 492 miRNAs were expressed in the DLBCL samples. Thirteen miRNAs showed significant differential expression between primary and relapse specimen pairs...
December 15, 2017: Blood Cancer Journal
https://www.readbyqxmd.com/read/29239593/clinical-significance-of-gene-defects-in-b-cell-lymphomas
#5
Annika Pasanen, Leo Meriranta, Sirpa Leppä
Lymphomas are a heterogenous group of malignant diseases. Identification of sub-groups has created pressure for a more detailed diagnosis and individualized treatment. Although the underlying genetic and molecular pathologic factors of the most common B-cell derived lymphomas, i.e. diffuse large B-cell lymphoma and follicular lymphoma, have become more accurate, prognosis is evaluated and treatment options still selected mainly on the basis of clinical variables. In the future, new generation sequencing methods that are becoming more common in clinical practice will allow the assessment of prognosis and treatment on the basis of biologic and genetic risk factors...
2017: Duodecim; Lääketieteellinen Aikakauskirja
https://www.readbyqxmd.com/read/29216744/dose-uniformity-of-budesonide-easyhaler%C3%A2-under-simulated-real-life-conditions-and-with-low-inspiration-flow-rates
#6
Jussi Haikarainen, Paula Rytilä, Sirkku Roos, Sirpa Metsärinne, Anita Happonen
Budesonide Easyhaler® multidose dry powder inhaler is approved for the treatment of asthma. Objectives were to determine the delivered dose (DD) uniformity of budesonide Easyhaler® in simulated real-world conditions and with different inspiration flow rates (IFRs). Three dose delivery studies were performed using 100, 200, and 400 µg/dose strengths of budesonide. Dose uniformity was assessed during in-use periods of 4-6 months after exposure to high temperature (30°C) and humidity (60% relative humidity) and after dropping and vibration testing...
January 1, 2017: Chronic Respiratory Disease
https://www.readbyqxmd.com/read/29184033/networks-of-enzymatically-oxidized-membrane-lipids-support-calcium-dependent-coagulation-factor-binding-to-maintain-hemostasis
#7
Sarah N Lauder, Keith Allen-Redpath, David A Slatter, Maceler Aldrovandi, Anne O'Connor, Daniel Farewell, Charles L Percy, Jessica E Molhoek, Sirpa Rannikko, Victoria J Tyrrell, Salvatore Ferla, Ginger L Milne, Alastair W Poole, Christopher P Thomas, Samya Obaji, Philip R Taylor, Simon A Jones, Phillip G de Groot, Rolf T Urbanus, Sohvi Hörkkö, Stefan Uderhardt, Jochen Ackermann, P Vince Jenkins, Andrea Brancale, Gerhard Krönke, Peter W Collins, Valerie B O'Donnell
Blood coagulation functions as part of the innate immune system by preventing bacterial invasion, and it is critical to stopping blood loss (hemostasis). Coagulation involves the external membrane surface of activated platelets and leukocytes. Using lipidomic, genetic, biochemical, and mathematical modeling approaches, we found that enzymatically oxidized phospholipids (eoxPLs) generated by the activity of leukocyte or platelet lipoxygenases (LOXs) were required for normal hemostasis and promoted coagulation factor activities in a Ca2+- and phosphatidylserine (PS)-dependent manner...
November 28, 2017: Science Signaling
https://www.readbyqxmd.com/read/29167014/the-effect-of-age-and-body-composition-on-body-mass-estimation-of-males-using-the-stature-bi-iliac-method
#8
Juho-Antti Junno, Markku Niskanen, Heli Maijanen, Brigitte Holt, Vladimir Sladek, Sirpa Niinimäki, Margit Berner
The stature/bi-iliac breadth method provides reasonably precise, skeletal frame size (SFS) based body mass (BM) estimations across adults as a whole. In this study, we examine the potential effects of age changes in anthropometric dimensions on the estimation accuracy of SFS-based body mass estimation. We use anthropometric data from the literature and our own skeletal data from two osteological collections to study effects of age on stature, bi-iliac breadth, body mass, and body composition, as they are major components behind body size and body size estimations...
November 19, 2017: Journal of Human Evolution
https://www.readbyqxmd.com/read/29166944/targeting-of-vascular-adhesion-protein-1-by-positron-emission-tomography-visualizes-sites-of-inflammation-in-borrelia-burgdorferi-infected-mice
#9
Riikka Siitonen, Annukka Pietikäinen, Heidi Liljenbäck, Meeri Käkelä, Mirva Söderström, Sirpa Jalkanen, Jukka Hytönen, Anne Roivainen
BACKGROUND: In the present study, we sought to evaluate the feasibility of targeting vascular adhesion protein-1 (VAP-1) by positron emission tomography (PET) for the longitudinal quantitative assessment of Borrelia burgdorferi infection-induced inflammation in mice. METHODS: Mice with B. burgdorferi infection-induced arthritis were studied. During a 7-week follow-up period, the progression of arthritis was monitored weekly with (68)Ga-DOTA-Siglec-9 PET/computed tomography (CT) and measurement of tibiotarsal joint swellings...
November 22, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29158380/anti-sirp%C3%AE-antibody-immunotherapy-enhances-neutrophil-and-macrophage-antitumor-activity
#10
Nan Guo Ring, Dietmar Herndler-Brandstetter, Kipp Weiskopf, Liang Shan, Jens-Peter Volkmer, Benson M George, Melanie Lietzenmayer, Kelly M McKenna, Tejaswitha J Naik, Aaron McCarty, Yunjiang Zheng, Aaron M Ring, Richard A Flavell, Irving L Weissman
Cancer immunotherapy has emerged as a promising therapeutic intervention. However, complete and durable responses are only seen in a fraction of patients who have cancer. A key factor that limits therapeutic success is the infiltration of tumors by cells of the myeloid lineage. The inhibitory receptor signal regulatory protein-α (SIRPα) is a myeloid-specific immune checkpoint that engages the "don't eat me" signal CD47 expressed on tumors and normal tissues. We therefore developed the monoclonal antibody KWAR23, which binds human SIRPα with high affinity and disrupts its binding to CD47...
November 20, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29149866/prevalence-and-risk-factors-of-frailty-among-home-care-clients
#11
Minna Miettinen, Miia Tiihonen, Sirpa Hartikainen, Irma Nykänen
BACKGROUND: Frailty is a common problem among older people and it is associated with an increased risk of death and long-term institutional care. Early identification of frailty is necessary to prevent a further decline in the health status of home care clients. The aims of the present study were to determine the prevalence of frailty and associated factors among 75-year-old or older home care clients. METHODS: The study participants were 75-year-old or older home care clients living in three cities in Eastern and Central Finland...
November 17, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/29143367/risk-of-death-associated-with-new-benzodiazepine-use-among-persons-with-alzheimer-disease-a-matched-cohort-study
#12
Laura Saarelainen, Anna-Maija Tolppanen, Marjaana Koponen, Antti Tanskanen, Jari Tiihonen, Sirpa Hartikainen, Heidi Taipale
OBJECTIVE: To investigate the risk of death associated with new benzodiazepine and related drug (BZDR) use in a nationwide cohort of persons with Alzheimer disease (AD). METHODS: The register-based MEDALZ cohort, including all community-dwelling Finns diagnosed with AD during 2005 to 2011 (n = 70 718), was used. Clinically verified AD diagnoses were obtained from the Special Reimbursement Register. Drug use periods were modeled from BZDR purchases, derived from the Prescription Register...
November 15, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29097701/two-missense-mutations-in-kcnq1-cause-pituitary-hormone-deficiency-and-maternally-inherited-gingival-fibromatosis
#13
Johanna Tommiska, Johanna Känsäkoski, Lasse Skibsbye, Kirsi Vaaralahti, Xiaonan Liu, Emily J Lodge, Chuyi Tang, Lei Yuan, Rainer Fagerholm, Jørgen K Kanters, Päivi Lahermo, Mari Kaunisto, Riikka Keski-Filppula, Sanna Vuoristo, Kristiina Pulli, Tapani Ebeling, Leena Valanne, Eeva-Marja Sankila, Sirpa Kivirikko, Mitja Lääperi, Filippo Casoni, Paolo Giacobini, Franziska Phan-Hug, Tal Buki, Manuel Tena-Sempere, Nelly Pitteloud, Riitta Veijola, Marita Lipsanen-Nyman, Kari Kaunisto, Patrice Mollard, Cynthia L Andoniadou, Joel A Hirsch, Markku Varjosalo, Thomas Jespersen, Taneli Raivio
Familial growth hormone deficiency provides an opportunity to identify new genetic causes of short stature. Here we combine linkage analysis with whole-genome resequencing in patients with growth hormone deficiency and maternally inherited gingival fibromatosis. We report that patients from three unrelated families harbor either of two missense mutations, c.347G>T p.(Arg116Leu) or c.1106C>T p.(Pro369Leu), in KCNQ1, a gene previously implicated in the long QT interval syndrome. Kcnq1 is expressed in hypothalamic GHRH neurons and pituitary somatotropes...
November 3, 2017: Nature Communications
https://www.readbyqxmd.com/read/29078283/humanized-mouse-model-supports-development-function-and-tissue-residency-of-human-natural-killer-cells
#14
Dietmar Herndler-Brandstetter, Liang Shan, Yi Yao, Carmen Stecher, Valerie Plajer, Melanie Lietzenmayer, Till Strowig, Marcel R de Zoete, Noah W Palm, Jie Chen, Catherine A Blish, Davor Frleta, Cagan Gurer, Lynn E Macdonald, Andrew J Murphy, George D Yancopoulos, Ruth R Montgomery, Richard A Flavell
Immunodeficient mice reconstituted with a human immune system represent a promising tool for translational research as they may allow modeling and therapy of human diseases in vivo. However, insufficient development and function of human natural killer (NK) cells and T cell subsets limit the applicability of humanized mice for studying cancer biology and therapy. Here, we describe a human interleukin 15 (IL15) and human signal regulatory protein alpha (SIRPA) knock-in mouse on a Rag2-/- Il2rg-/- background (SRG-15)...
November 7, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29065711/vascular-adhesion-protein-1-a-cell-surface-amine-oxidase-in-translation
#15
Sirpa Jalkanen, Marko Salmi
SIGNIFICANCE: Vascular adhesion protein-1 (VAP-1) is an ectoenzyme, which oxidates primary amines in a reaction producing also hydrogen peroxide. VAP-1 on the blood vessel endothelium regulates leukocyte extravasation from the blood into tissues under physiological and pathological conditions. Recent advances: Inhibition of VAP-1 by neutralizing antibodies and by several novel small molecule enzyme inhibitors interferes with leukocyte trafficking and alleviates inflammation in many experimental models...
October 25, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29056311/an-international-prospective-cohort-study-of-mobile-phone-users-and-health-cosmos-factors-affecting-validity-of-self-reported-mobile-phone-use
#16
Mireille B Toledano, Anssi Auvinen, Giorgio Tettamanti, Yang Cao, Maria Feychting, Anders Ahlbom, Karin Fremling, Sirpa Heinävaara, Katja Kojo, Gemma Knowles, Rachel B Smith, Joachim Schüz, Christoffer Johansen, Aslak Harbo Poulsen, Isabelle Deltour, Roel Vermeulen, Hans Kromhout, Paul Elliott, Lena Hillert
This study investigates validity of self-reported mobile phone use in a subset of 75 993 adults from the COSMOS cohort study. Agreement between self-reported and operator-derived mobile call frequency and duration for a 3-month period was assessed using Cohen's weighted Kappa (κ). Sensitivity and specificity of both self-reported high (≥10 calls/day or ≥4h/week) and low (≤6 calls/week or <30min/week) mobile phone use were calculated, as compared to operator data. For users of one mobile phone, agreement was fair for call frequency (κ=0...
September 20, 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/29055031/impact-of-gender-neutral-or-girls-only-vaccination-against-human-papillomavirus-results-of-a-community-randomized-clinical-trial-i
#17
Matti Lehtinen, Anna Söderlund-Strand, Simopekka Vänskä, Tapio Luostarinen, Tiina Eriksson, Kari Natunen, Dan Apter, Iacopo Baussano, Katja Harjula, Mari Hokkanen, Marjo Kuortti, Johanna Palmroth, Tiina Petäjä, Eero Pukkala, Sirpa Rekonen, Mari Siitari-Mattila, Heljä-Marja Surcel, Leena Tuomivaara, Jorma Paavonen, Joakim Dillner, Gary Dubin, Geoffrey Garnett
Human papillomavirus (HPV) vaccine is efficacious but the real-life effectiveness of gender-neutral and girls-only vaccination strategies is unknown. We report a community-randomized trial on the protective effectiveness [(PE) = vaccine efficacy (VE) + herd effect (HE)] of the two strategies among females in virtually HPV vaccination naïve population. We randomized 33 Finnish communities into Arm A) gender-neutral vaccination with AS04-adjuvanted HPV16/18 vaccine (11 communities), Arm B) HPV vaccination of girls and hepatitis B-virus (HBV) vaccination of boys (11 communities) or Arm C) gender-neutral HBV vaccination (11 communities)...
October 21, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29040144/surgical-treatment-of-dentofacial-deformities-caused-by-juvenile-idiopathic-arthritis
#18
Patricia Stoor, Zlatan Hodzic, Sirpa Arte
The purpose of our retrospective study was to evaluate the results of orthognathic treatment, distraction osteogenesis, and/or prosthetic reconstruction of the temporomandibular joints in patients with juvenile idiopathic arthritis (JIA).Twelve patients with severely affected temporomandibular joints (TMJs) and reduced ramus height were treated with mandibular advancement with orthognathic surgery (11) and additional bilateral or unilateral mandibular ramus distraction (3) or additional bilateral or unilateral prosthetic reconstruction of the TMJ (3)...
October 16, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29025166/is-alzheimer-s-disease-associated-with-previous-opioid-use
#19
Heidi Taipale, Aleksi Hamina, Pasi Lampela, Antti Tanskanen, Jari Tiihonen, Niina Karttunen, Anna-Maija Tolppanen, Sirpa Hartikainen
Objective: We investigated whether opioid use, duration of use, and cumulative dose are associated with an increased risk of Alzheimer's disease (AD). Methods: A Finnish nationwide nested case-control study, MEDALZ, included 70,718 individuals with AD and up to four age-, sex-, and region of residence-matched comparison individuals. The cohort included all Finnish persons with a clinically verified AD diagnosis during 2005 to 2011; the mean age was 80 years (SD = 7 years), and 65% were women...
August 28, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29020299/lifestyle-in-population-based-colorectal-cancer-screening-over-2-year-follow-up
#20
Sanni Helander, Sirpa Heinävaara, Tytti Sarkeala, Nea Malila
Background: Colorectal cancer (CRC) screening may cause changes in health-related lifestyle. In 2010, Finnish Mass Screening Registry began a study on psychosocial effects of CRC screening. This article examines whether there are differential developments in self-reported lifestyle at ages 59-61 years among CRC screening invitees and non-contacted controls. Methods: A population-based random sample of 10 648 Finnish adults born in 1951 and living in the municipalities voluntary involved in the CRC screening programme were sent a lifestyle questionnaire in 2010...
September 15, 2017: European Journal of Public Health
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