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https://www.readbyqxmd.com/read/28545141/prion-pathogenesis-is-unaltered-in-the-absence-of-sirp%C3%AE-mediated-don-t-eat-me-signaling
#1
Mario Nuvolone, Marta Paolucci, Silvia Sorce, Veronika Kana, Rita Moos, Takashi Matozaki, Adriano Aguzzi
Prion diseases are neurodegenerative conditions caused by misfolding of the prion protein, leading to conspicuous neuronal loss and intense microgliosis. Recent experimental evidence point towards a protective role of microglia against prion-induced neurodegeneration, possibly through elimination of prion-containing apoptotic bodies. The molecular mechanisms by which microglia recognize and eliminate apoptotic cells in the context of prion diseases are poorly defined. Here we investigated the possible involvement of signal regulatory protein α (SIRPα), a key modulator of host cell phagocytosis; SIRPα is encoded by the Sirpa gene that is genetically linked to the prion gene Prnp...
2017: PloS One
https://www.readbyqxmd.com/read/28537101/clinical-findings-in-25-patients-with-sinonasal-or-nasopharyngeal-extramedullary-plasmacytoma-in-a-four-decade-single-centre-series
#2
Seija Inkeri Vento, Pauli Vähämurto, Kaija Silventoinen, Marja-Liisa Karjalainen-Lindsberg, Susanna Mannisto, Sirpa Leppä, Antti Aarni Mäkitie
OBJECTIVES: Extramedullary plasmacytoma in the sinonasal tract or nasopharynx is rare. The aim of the study was to review data on symptoms, clinical findings, treatment and follow-up of plasmacytomas in the sinonasal and nasopharyngeal regions in order to delineate the main clinical characteristics and the optimal management. METHOD: Twenty-five patients with sinonasal or nasopharyngeal plasmacytoma, diagnosed and treated at the Helsinki University Hospital during a 39-year period from 1975 to 2013 were retrospectively reviewed...
May 24, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28502405/a-practical-guidance-for-assessments-of-sedentary-behavior-at-work-a-perosh-initiative
#3
Andreas Holtermann, Vera Schellewald, Svend Erik Mathiassen, Nidhi Gupta, Andrew Pinder, Anne Punakallio, Kaj Bo Veiersted, Britta Weber, Esa-Pekka Takala, Francesco Draicchio, Henrik Enquist, Kevin Desbrosses, Maria Peñahora García Sanz, Marzena Malińska, María Villar, Michael Wichtl, Michaela Strebl, Mikael Forsman, Sirpa Lusa, Tomasz Tokarski, Peter Hendriksen, Rolf Ellegast
Sedentary behavior is defined as sitting or lying with low energy expenditure. Humans in industrialized societies spend an increasing amount of time in sedentary behaviors every day. This has been associated with detrimental health outcomes. Despite a growing interest in the health effects of sedentary behavior at work, associations remain unclear, plausibly due to poor and diverse methods for assessing sedentary behavior. Thus, good practice guidance for researchers and practitioners on how to assess occupational sedentary behavior are needed...
September 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/28486815/incident-use-of-a-potentially-inappropriate-medication-and-hip-fracture-in-community-dwelling-older-persons-with-alzheimer-s-disease
#4
Virva Hyttinen, Heidi Taipale, Anna-Maija Tolppanen, Antti Tanskanen, Jari Tiihonen, Sirpa Hartikainen, Hannu Valtonen
BACKGROUND: Potentially inappropriate medications (PIMs) increase the risk of adverse drug reactions and events and have been associated with greater health care service use, such as an increased risk of hospitalization. OBJECTIVE: The aim of this study is to evaluate the association between PIM use and hip fractures in a nationwide cohort of community-dwelling persons ≥65 years old with Alzheimer's disease (AD). METHODS: The study, which is based on the Finnish nationwide MEDALZ cohort, included all persons diagnosed with AD between 2005 and 2011 (n = 70 718)...
May 1, 2017: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/28481341/genome-sequencing-and-population-genomic-analyses-provide-insights-into-the-adaptive-landscape-of-silver-birch
#5
Jarkko Salojärvi, Olli-Pekka Smolander, Kaisa Nieminen, Sitaram Rajaraman, Omid Safronov, Pezhman Safdari, Airi Lamminmäki, Juha Immanen, Tianying Lan, Jaakko Tanskanen, Pasi Rastas, Ali Amiryousefi, Balamuralikrishna Jayaprakash, Juhana I Kammonen, Risto Hagqvist, Gugan Eswaran, Viivi Helena Ahonen, Juan Alonso Serra, Fred O Asiegbu, Juan de Dios Barajas-Lopez, Daniel Blande, Olga Blokhina, Tiina Blomster, Suvi Broholm, Mikael Brosché, Fuqiang Cui, Chris Dardick, Sanna E Ehonen, Paula Elomaa, Sacha Escamez, Kurt V Fagerstedt, Hiroaki Fujii, Adrien Gauthier, Peter J Gollan, Pauliina Halimaa, Pekka I Heino, Kristiina Himanen, Courtney Hollender, Saijaliisa Kangasjärvi, Leila Kauppinen, Colin T Kelleher, Sari Kontunen-Soppela, J Patrik Koskinen, Andriy Kovalchuk, Sirpa O Kärenlampi, Anna K Kärkönen, Kean-Jin Lim, Johanna Leppälä, Lee Macpherson, Juha Mikola, Katriina Mouhu, Ari Pekka Mähönen, Ülo Niinemets, Elina Oksanen, Kirk Overmyer, E Tapio Palva, Leila Pazouki, Ville Pennanen, Tuula Puhakainen, Péter Poczai, Boy J H M Possen, Matleena Punkkinen, Moona M Rahikainen, Matti Rousi, Raili Ruonala, Christiaan van der Schoot, Alexey Shapiguzov, Maija Sierla, Timo P Sipilä, Suvi Sutela, Teemu H Teeri, Arja I Tervahauta, Aleksia Vaattovaara, Jorma Vahala, Lidia Vetchinnikova, Annikki Welling, Michael Wrzaczek, Enjun Xu, Lars G Paulin, Alan H Schulman, Martin Lascoux, Victor A Albert, Petri Auvinen, Ykä Helariutta, Jaakko Kangasjärvi
Silver birch (Betula pendula) is a pioneer boreal tree that can be induced to flower within 1 year. Its rapid life cycle, small (440-Mb) genome, and advanced germplasm resources make birch an attractive model for forest biotechnology. We assembled and chromosomally anchored the nuclear genome of an inbred B. pendula individual. Gene duplicates from the paleohexaploid event were enriched for transcriptional regulation, whereas tandem duplicates were overrepresented by environmental responses. Population resequencing of 80 individuals showed effective population size crashes at major points of climatic upheaval...
June 2017: Nature Genetics
https://www.readbyqxmd.com/read/28424246/enteropathy-associated-t-cell-lymphoma-subtypes-are-characterized-by-loss-of-function-of-setd2
#6
Andrea B Moffitt, Sarah L Ondrejka, Matthew McKinney, Rachel E Rempel, John R Goodlad, Chun Huat Teh, Sirpa Leppa, Susanna Mannisto, Panu E Kovanen, Eric Tse, Rex K H Au-Yeung, Yok-Lam Kwong, Gopesh Srivastava, Javeed Iqbal, Jiayu Yu, Kikkeri Naresh, Diego Villa, Randy D Gascoyne, Jonathan Said, Magdalena B Czader, Amy Chadburn, Kristy L Richards, Deepthi Rajagopalan, Nicholas S Davis, Eileen C Smith, Brooke C Palus, Tiffany J Tzeng, Jane A Healy, Patricia L Lugar, Jyotishka Datta, Cassandra Love, Shawn Levy, David B Dunson, Yuan Zhuang, Eric D Hsi, Sandeep S Dave
Enteropathy-associated T cell lymphoma (EATL) is a lethal, and the most common, neoplastic complication of celiac disease. Here, we defined the genetic landscape of EATL through whole-exome sequencing of 69 EATL tumors. SETD2 was the most frequently silenced gene in EATL (32% of cases). The JAK-STAT pathway was the most frequently mutated pathway, with frequent mutations in STAT5B as well as JAK1, JAK3, STAT3, and SOCS1 We also identified mutations in KRAS, TP53, and TERT Type I EATL and type II EATL (monomorphic epitheliotropic intestinal T cell lymphoma) had highly overlapping genetic alterations indicating shared mechanisms underlying their pathogenesis...
May 1, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28415993/moving-to-business-changes-in-physical-activity-and-sedentary-behavior-after-multilevel-intervention-in-small-and-medium-size-workplaces
#7
Minna Aittasalo, Matleena Livson, Sirpa Lusa, Ahti Romo, Henri Vähä-Ypyä, Kari Tokola, Harri Sievänen, Ari Mänttäri, Tommi Vasankari
BACKGROUND: Regular physical activity (PA) promotes and excessive sedentary behavior (SB) deteriorates health. Yet the Finnish working-aged population spends most of the day sitting. A 1-year Moving To Business (MTB) -intervention supported small and medium-size workplaces to combat sedentariness. This paper reports the changes in employees' PA and SB from before MTB (baseline) to 1 year after baseline (follow-up). METHODS: Twelve workplaces with a total of 396 employees participated...
April 17, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28414159/in-vitro-toxicological-effects-of-zinc-containing-nanoparticles-with-different-physico-chemical-properties
#8
Oskari Uski, Tiina Torvela, Olli Sippula, Tommi Karhunen, Hanna Koponen, Sirpa Peräniemi, Pasi Jalava, Mikko Happo, Jorma Jokiniemi, Maija-Riitta Hirvonen, Anna Lähde
Nanomaterials (NM) exhibit novel physicochemical properties that determine their interaction with biological substrates and processes. Recent nano-technological advances are leading to wide usage of metallic nanoparticles (NPs) in various fields. However, the increasing use of NPs has led to their release into environment and the toxicity of NPs on human health has become a concern. Moreover, there are inadvertently generated metallic NPs which are formed during various human activities (e.g. metal processing and energy production)...
April 14, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28396328/risk-of-pneumonia-associated-with-incident-benzodiazepine-use-among-community-dwelling-adults-with-alzheimer-disease
#9
Heidi Taipale, Anna-Maija Tolppanen, Marjaana Koponen, Antti Tanskanen, Piia Lavikainen, Reijo Sund, Jari Tiihonen, Sirpa Hartikainen
BACKGROUND: Knowledge regarding whether benzodiazepines and similarly acting non-benzodiazepines (Z-drugs) are associated with an increased risk of pneumonia among older adults is lacking. We sought to investigate this association among community-dwelling adults with Alzheimer disease, a condition in which both sedative/hypnotic use and pneumonia are common. METHODS: We obtained data on all community-dwelling adults with a recent diagnosis of Alzheimer disease in Finland (2005-2011) from the Medication use and Alzheimer disease (MEDALZ) cohort, which incorporates national registry data on prescriptions, reimbursement, hospital discharges and causes of death...
April 10, 2017: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/28386104/intubation-free-in-vivo-imaging-of-the-tracheal-mucosa-using-two-photon-microscopy
#10
Tibor Z Veres, Tamás Kopcsányi, Marko Tirri, Armin Braun, Masayuki Miyasaka, Ronald N Germain, Sirpa Jalkanen, Marko Salmi
The mucosal layer of conducting airways is the primary tissue exposed to inhaled microorganisms, allergens and pollutants. We developed an in vivo two-photon microscopic approach that allows performing dynamic imaging studies in the mouse trachea, which is a commonly used in vivo model of human small-diameter bronchi. By providing stabilized access to the tracheal mucosa without intubation, our setup uniquely allows dynamic in vivo imaging of mucociliary clearance and steady-state immune cell behavior within the complex airway mucosal tissue...
April 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28383029/genetic-mutation-and-exosome-signature-of-human-papilloma-virus-associated-oropharyngeal-cancer
#11
Anbarasu Kannan, Kate L Hertweck, Julie V Philley, Robert B Wells, Santanu Dasgupta
Human papilloma virus-16 (HPV-16) associated oropharyngeal cancer (HPVOPC) is increasing alarmingly in the United States. We performed whole genome sequencing of a 44 year old, male HPVOPC subject diagnosed with moderately differentiated tonsillar carcinoma. We identified new somatic mutation in MUC16 (A.k.a. CA-125), MUC12, MUC4, MUC6, MUC2, SIRPA, HLA-DRB1, HLA-A and HLA-B molecules. Increased protein expression of MUC16, SIRPA and decreased expression of HLA-DRB1 was further demonstrated in this HPVOPC subject and an additional set of 15 HPVOPC cases...
April 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28375212/faecalibacterium-prausnitzii-treatment-improves-hepatic-health-and-reduces-adipose-tissue-inflammation-in-high-fat-fed-mice
#12
Eveliina Munukka, Anniina Rintala, Raine Toivonen, Matts Nylund, Baoru Yang, Anna Takanen, Arno Hänninen, Jaana Vuopio, Pentti Huovinen, Sirpa Jalkanen, Satu Pekkala
Faecalibacterium prausnitzii is considered as one of the most important bacterial indicators of a healthy gut. We studied the effects of oral F. prausnitzii treatment on high-fat fed mice. Compared to the high-fat control mice, F. prausnitzii-treated mice had lower hepatic fat content, aspartate aminotransferase and alanine aminotransferase, and increased fatty acid oxidation and adiponectin signaling in liver. Hepatic lipidomic analyses revealed decreases in several species of triacylglycerols, phospholipids and cholesteryl esters...
April 4, 2017: ISME Journal
https://www.readbyqxmd.com/read/28339536/successful-nutrition-policy-improvement-of-vitamin-d-intake-and-status-in-finnish-adults-over-the-last-decade
#13
Susanna Raulio, Iris Erlund, Satu Männistö, Sirpa Sarlio-Lähteenkorva, Jouko Sundvall, Heli Tapanainen, Erkki Vartiainen, Suvi M Virtanen
Due to vitamin D intake below recommendation (10 µg/day) and low (<50 nmol/l) serum 25-hydroxycholecalciferol (25(OH)D) concentration in Finnish population, the fortification of liquid dairy products with 0.5 µg vitamin D/100 g and fat spreads with 10 µg/100 g started in Finland in December 2002. In 2010, the fortification recommendation was doubled. The aim of this study was to investigate whether the vitamin D intake and status have improved among Finnish adults as a consequence of these nutrition policy actions...
October 6, 2016: European Journal of Public Health
https://www.readbyqxmd.com/read/28339338/fertility-treatments-among-female-cancer-survivors-giving-birth-a-finnish-register-based-study
#14
Johanna Melin, Laura Madanat-Harjuoja, Sirpa Heinävaara, Nea Malila, Mika Gissler, Aila Tiitinen
BACKGROUND: Long-term survival rates for most types of childhood cancers have improved dramatically over the past decades. However, because of advances in multimodality treatments, cancer survivors nowadays more often face long-term complications, including diminished gonadal and reproductive function. The aim of this study was to identify whether the use of fertility treatments among early onset (0-34 years) cancer survivors giving birth differed from that among siblings giving birth and to identify the subgroups of cancer survivors that were most likely to require fertility treatments...
March 24, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28331284/a-retrospective-study-comparing-outcomes-of-primary-rhegmatogenous-retinal-detachment-repair-by-scleral-buckling-and-pars-plana-vitrectomy-in-finland
#15
Sari Sahanne, Raimo Tuuminen, Jari Haukka, Sirpa Loukovaara
BACKGROUND: Rhegmatogenous retinal detachment (RRD) is the most common form of retinal detachment and an ophthalmic emergency. Here, we compared outcomes of primary RRD eyes operated with conventional scleral buckling (SB) with cryoretinopexy to those operated with standard pars plana vitrectomy (PPV). METHODS: This is an institutional, retrospective, register-based, observational, comparative study. Based on the surgical procedure, 319 eyes of 319 patients were divided into two groups: SB plus cryotherapy (n=50) and PPV (n=269)...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28327550/significant-role-of-collagen-xvii-and-integrin-%C3%AE-4-in-migration-and-invasion-of-the-less-aggressive-squamous-cell-carcinoma-cells
#16
Jyri M Moilanen, Stefanie Löffek, Nina Kokkonen, Sirpa Salo, Juha P Väyrynen, Tiina Hurskainen, Aki Manninen, Pilvi Riihilä, Ritva Heljasvaara, Claus-Werner Franzke, Veli-Matti Kähäri, Tuula Salo, Markus J Mäkinen, Kaisa Tasanen
Collagen XVII and integrin α6β4 have well-established roles as epithelial adhesion molecules. Their binding partner laminin 332 as well as integrin α6β4 are largely recognized to promote invasion and metastasis in various cancers, and collagen XVII is essential for the survival of colon and lung cancer stem cells. We have studied the expression of laminin γ2, collagen XVII and integrin β4 in tissue microarray samples of squamous cell carcinoma (SCC) and its precursors, actinic keratosis and Bowen's disease...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28293474/transition-from-oxcarbazepine-to-eslicarbazepine-acetate-a-single-center-study
#17
Jussi Mäkinen, Sirpa Rainesalo, Jukka Peltola
OBJECTIVES: There is limited clinical evidence for comparison between oxcarbazepine (OXC) and eslicarbazepine acetate (ESL) in terms of tolerability, or how to execute the change from OXC to ESL. We report the process of transitioning patients with focal epilepsy from previous OXC treatment to ESL due to tolerability problems. The rationale for change from OXC is reported, and the outcome with respective to this rationale is analyzed in terms of tolerability and efficacy. MATERIALS AND METHODS: The subjects were transitioned overnight from OXC to ESL in a hospital inpatient setting...
March 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28282542/the-effect-of-newer-antiepileptic-drugs-in-combination-therapy
#18
Jussi Mäkinen, Sirpa Rainesalo, Jani Raitanen, Jukka Peltola
PURPOSE: To assess the impact of the new AEDs on overall outcome for patients with epilepsy. METHODS: In 2004, the effect of combination therapy on seizure frequency in adult patients with focal epilepsy was evaluated in a cross-sectional study in our center. We repeated this analysis ten years and eight new antiepileptic drugs (AED) later. RESULTS: In 2014, a higher percentage of patients with polytherapy (117 out of 396; 30%) were seizure-free compared with the original analysis (22%) (p=0...
May 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28278245/regional-changes-in-psychotropic-use-among-finnish-persons-with-newly-diagnosed-alzheimer-s-disease-in-2005-2011
#19
Anna-Maija Tolppanen, Ari Voutilainen, Heidi Taipale, Antti Tanskanen, Piia Lavikainen, Marjaana Koponen, Jari Tiihonen, Sirpa Hartikainen
OBJECTIVES: To describe and compare temporal changes in prevalence and incidence of psychotropic use (antipsychotics, antidepressants and benzodiazepines and related drugs; BZDRs) in persons with newly diagnosed Alzheimer's disease (AD) between university hospital districts of Finland during 2005-2011. METHODS: The MEDALZ study includes all community-dwellers of Finland who received a clinically verified AD diagnosis in 2005-2011 (N = 70,718). Prevalent and incident use of psychotropics among those who had received AD diagnosis less than one year ago were compared in 2005-2011...
2017: PloS One
https://www.readbyqxmd.com/read/28274328/risk-of-alzheimer-s-disease-among-users-of-postmenopausal-hormone-therapy-a-nationwide-case-control-study
#20
Bushra Imtiaz, Heidi Taipale, Antti Tanskanen, Miia Tiihonen, Miia Kivipelto, Anna-Mari Heikkinen, Jari Tiihonen, Hilkka Soininen, Sirpa Hartikainen, Anna-Maija Tolppanen
OBJECTIVE: To examine the association between postmenopausal hormone therapy (HT) and Alzheimer's disease (AD). METHODS: Medicine and Alzheimer's disease (MEDALZ) is a nested case-control study of the entire Finnish population with clinically verified AD from 2005 to 2011 and up to 4 matched controls per case. This study comprises 230,580 women (46,117 cases and 184,463 controls). Data on HT use from 1995 to 2011 was extracted from the national prescription register using following ATC codes: G03C (estrogen), G03D (progestogen) and G03F (estrogen and progestogen in combination)...
April 2017: Maturitas
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