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https://www.readbyqxmd.com/read/28942994/impact-of-organized-and-opportunistic-pap-testing-on-the-risk-of-cervical-cancer-in-young-women-a-case-control-study-from-finland
#1
Petra Makkonen, Sirpa Heinävaara, Tytti Sarkeala, Ahti Anttila
OBJECTIVE: Effectiveness of organized cervical cancer screening has been shown in several studies. However, screening among women aged <25years has been suggested to have little or no impact on the risk of cervical cancer. Also the significance of opportunistic testing in preventing cervical cancer is unclear. The aim of this study was to clarify the effect of opportunistic testing and organized screening on the risk of cervical cancer among young Finnish women. METHODS: In the Finnish Cancer Registry there were 284 cervical cancer cases diagnosed and tested below the age of 40 in 2004-2009...
September 21, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28940566/anticholinergic-burden-and-dry-mouth-among-finnish-community-dwelling-older-adults
#2
Antti Tiisanoja, Anna-Maija Syrjälä, Kaija Komulainen, Pasi Lampela, Sirpa Hartikainen, Heidi Taipale, Matti Knuuttila, Pekka Ylöstalo
OBJECTIVE: The aim was to study whether the anticholinergic burden of drugs is related to xerostomia and salivary secretion among community-dwelling elderly people. BACKGROUND: Anticholinergic drugs have been shown to be a risk factor for dry mouth, but little is known about the effects of cumulative exposure to anticholinergic drugs measured by anticholinergic burden on salivary secretion or xerostomia. METHODS: The study population consisted of 152 community-dwelling, dentate, non-smoking, older people from the Oral Health GeMS study...
September 21, 2017: Gerodontology
https://www.readbyqxmd.com/read/28886089/drug-exposure-in-register-based-research-an-expert-opinion-based-evaluation-of-methods
#3
Antti Tanskanen, Heidi Taipale, Marjaana Koponen, Anna-Maija Tolppanen, Sirpa Hartikainen, Riitta Ahonen, Jari Tiihonen
BACKGROUND: In register-based pharmacoepidemiological studies, construction of drug exposure periods from drug purchases is a major methodological challenge. Various methods have been applied but their validity is rarely evaluated. Our objective was to conduct an expert-opinion based evaluation of the correctness of drug use periods produced by different methods. METHODS: Drug use periods were calculated with three fixed methods: time windows, assumption of one Defined Daily Dose (DDD) per day and one tablet per day, and with PRE2DUP that is based on modelling of individual drug purchasing behavior...
2017: PloS One
https://www.readbyqxmd.com/read/28857986/craniofacial-and-dental-features-in-six-children-with-cherubism
#4
Patricia Stoor, Anni Suomalainen, Maarit Kemola, Sirpa Arte
Cherubism is an autosomal-dominant benign bone disorder, characterized by fibro-osseous lesions in the mandible and maxilla commonly caused by mutations in the SH3-binding protein 2-gene. The purpose of the authors' study was to analyze craniofacial and dental features of children diagnosed with cherubism, describe their treatment, and assess their dental age compared with norms for Finnish children. Six children were diagnosed, followed up and treated due to dental and skeletal disorders caused by cherubsim...
August 28, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28851562/viral-load-affects-the-immune-response-to-hbv-in-mice-with-humanized-immune-system-and-liver
#5
Mathilde Dusséaux, Guillemette Masse-Ranson, Sylvie Darche, James Ahodantin, Yan Li, Oriane Fiquet, Elodie Beaumont, Pierrick Moreau, Lise Rivière, Christine Neuveut, Patrick Soussan, Philippe Roingeard, Dina Kremsdorf, James P Di Santo, Helene Strick-Marchand
BACKGROUND & AIMS: Hepatitis B virus (HBV) infects hepatocytes, but the mechanisms of the immune response against the virus, and how it affects disease progression, are unclear. METHODS: We performed studies with BALB/c Rag2(-/-)Il2rg(-/-)Sirpa(NOD)Alb-uPA(tg/tg) mice, stably engrafted with human hepatocytes (HUHEP) with or without a human immune system (HIS). HUHEP and HIS-HUHEP mice were given an intraperitoneal injection of HBV. Mononuclear cells were isolated from spleen and liver for analysis by flow cytometry...
August 26, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28846458/effects-of-regular-exercise-on-asthma-control-in-young-adults
#6
Sirpa A M Heikkinen, Elina M S Mäkikyrö, Timo T Hugg, Maritta S Jaakkola, Jouni J K Jaakkola
BACKGROUND: According to our systematic literature review, no previous study has assessed potential effects of regular exercise on asthma control among young adults. We hypothesized that regular exercise improves asthma control among young adults. METHODS: We studied 162 subjects with current asthma recruited from a population-based cohort study of 1623 young adults 20-27 years of age. Asthma control was assessed by the occurrence of asthma-related symptoms, including wheezing, shortness of breath, cough, and phlegm production, during the past 12 months...
August 28, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28834781/clinical-management-of-elderly-patients-with-epilepsy-the-use-of-lacosamide-in-a-single-center-setting
#7
Sirpa Rainesalo, Jussi Mäkinen, Jani Raitanen, Jukka Peltola
INTRODUCTION: Lacosamide (LCM) is a third-generation antiepileptic drug (AED) for which there is limited experience in the treatment of elderly patients with epilepsy. This study was performed to evaluate the use of LCM in this particular patient group, focusing on its tolerability and effectiveness. This is a retrospective, single-center study, in patients over 60years old treated with LCM between 1/2010 and 5/2015. Altogether, 233 elderly patients receiving LCM were identified; of these, 67 fulfilled the inclusion criteria, i...
August 20, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28783664/donor-sirp%C3%AE-polymorphism-modulates-the-innate-immune-response-to-allogeneic-grafts
#8
Hehua Dai, Andrew J Friday, Khodor I Abou-Daya, Amanda L Williams, Steven Mortin-Toth, Matthew L Nicotra, David M Rothstein, Warren D Shlomchik, Takashi Matozaki, Jeffrey S Isenberg, Martin H Oberbarnscheidt, Jayne S Danska, Fadi G Lakkis
Mice devoid of T, B, and natural killer (NK) cells distinguish between self and allogeneic nonself despite the absence of an adaptive immune system. When challenged with an allograft, they mount an innate response characterized by accumulation of mature, monocyte-derived dendritic cells (DCs) that produce interleukin-12 and present antigen to T cells. However, the molecular mechanisms by which the innate immune system detects allogeneic nonself to generate these DCs are not known. To address this question, we studied the innate response of Rag2(-/-) γc(-/-) mice, which lack T, B, and NK cells, to grafts from allogeneic donors...
June 23, 2017: Science Immunology
https://www.readbyqxmd.com/read/28764750/risk-of-head-and-traumatic-brain-injuries-associated-with-antidepressant-use-among-community-dwelling-persons-with-alzheimer-s-disease-a-nationwide-matched-cohort-study
#9
Heidi Taipale, Marjaana Koponen, Antti Tanskanen, Piia Lavikainen, Reijo Sund, Jari Tiihonen, Sirpa Hartikainen, Anna-Maija Tolppanen
BACKGROUND: Antidepressant use has been associated with an increased risk of falling, but no studies have been conducted on whether antidepressant use is associated with an increased risk of head injuries which often result from falling among older persons. The objective of this study was to investigate the risk of head and brain injuries associated with antidepressant use among community-dwelling persons with Alzheimer's disease. METHODS: A matched cohort study was conducted by comparing new antidepressant users (n = 10,910) with two matched nonusers (n = 21,820) in the MEDALZ study cohort...
August 1, 2017: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/28757385/trueness-and-precision-of-the-real-time-rt-pcr-method-for-quantifying-the-chronic-bee-paralysis-virus-genome-in-bee-homogenates-evaluated-by-a-comparative-inter-laboratory-study
#10
Frank Schurr, Nicolas Cougoule, Marie-Pierre Rivière, Magali Ribière-Chabert, Hamid Achour, Dán Ádám, Carlos Castillo, Dirk C de Graaf, Eva Forsgren, Anna Granato, Sirpa Heinikainen, Júlia Jurovčíková, Per Kryger, Christine Manson, Marie-Françoise Ménard, Stéphane Perennes, Marc O Schäfer, Elena San Miguel Ibañez, João Silva, Ivana Tlak Gajger, Victoria Tomkies, Ivan Toplak, Alain Viry, Dagmara Zdańska, Eric Dubois
The Chronic bee paralysis virus (CBPV) is the aetiological agent of chronic bee paralysis, a contagious disease associated with nervous disorders in adult honeybees leading to massive mortalities in front of the hives. Some of the clinical signs frequently reported, such as trembling, may be confused with intoxication syndromes. Therefore, laboratory diagnosis using real-time PCR to quantify CBPV loads is used to confirm disease. Clinical signs of chronic paralysis are usually associated with viral loads higher than 10(8) copies of CBPV genome copies per bee (8 log10 CBPV/bee)...
October 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28735836/importance-of-deformable-image-registration-and-biological-dose-summation-in-planning-of-radiotherapy-retreatments
#11
Eeva Boman, Mika Kapanen, Lyndsey Pickup, Sirpa-Liisa Lahtela
The purpose of this study is to evaluate the effect of nonrigid and fractionation-corrected dose summation on total doses in radiotherapy and to demonstrate the benefits of such dose summation on clinical decision-making for planning of retreatments. Dose summation of organs at risk (OARs) was investigated for 3 clinical cases with need of retreatment to the same site: head and neck, brain, and mediastinum. Three different summation methods over old and new radiotherapy treatment plans are presented and compared: (1) rigid raw sum with rigid registration of the planning images and direct dose summing; (2) deformable raw sum with deformable image registration and direct dose summing; and (3) deformable biological sum with deformable registration and takes into account the dose per fraction in biological manner in certain critical organs...
July 20, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28699419/chair-rise-capacity-and-associated-factors-in-older-home-care-clients
#12
Miia Tiihonen, Sirpa Hartikainen, Irma Nykänen
AIMS: The aim of this study was to investigate the ability of older home-care clients to perform the five times chair rise test and associated personal characteristics, nutritional status and functioning. METHODS: The study sample included 267 home-care clients aged ≥75 years living in Eastern and Central Finland. The home-care clients were interviewed at home by home-care nurses, nutritionists and pharmacists. The collected data contained sociodemographic factors, functional ability (Barthel Index, IADL), cognitive functioning (MMSE), nutritional status (MNA), depressive symptoms (GDS-15), medical diagnoses and drug use...
July 1, 2017: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/28697424/peak-exposures-to-main-components-of-ash-and-gaseous-diesel-exhausts-in-closed-and-open-ash-loading-stations-at-biomass-fuelled-power-plants
#13
Juha Laitinen, Hanna Koponen, Olli Sippula, Kirsi Korpijärvi, Mika Jumpponen, Sirpa Laitinen, Marjaleena Aatamila, Jarkko Tissari, Tommi Karhunen, Kari Ojanen, Jorma Jokiniemi, Leena Korpinen
Fly and bottom ashes are collected at power plants to reduce the environmental effects of energy production. However, handling the ashes causes health problems for operators, maintenance workers and truck drivers at the power plants. Hence, we evaluated ash loaders' peak inhalation exposures to the chemical components of ash and diesel exhausts in open and closed ash loading stations at biomass-fuelled combined heat and power plants. We also carried out chemical and morphological analyses of the ashes to evaluate their health hazard potential in order to find practical technical measures to reduce workers' exposure...
July 4, 2017: Chemosphere
https://www.readbyqxmd.com/read/28695906/no-association-between-proton-pump-inhibitor-use-and-risk-of-alzheimer-s-disease
#14
Heidi Taipale, Anna-Maija Tolppanen, Miia Tiihonen, Antti Tanskanen, Jari Tiihonen, Sirpa Hartikainen
OBJECTIVES: The objective of the study was to investigate whether proton pump inhibitor (PPI) use is associated with an increased risk of clinically verified Alzheimer's disease (AD). METHODS: A Finnish nationwide nested case-control study MEDALZ includes all community-dwelling individuals with newly diagnosed AD during 2005-2011 (N=70,718), and up to four age-, sex-, and region of residence-matched comparison individuals for each case (N=282,858). Data were extracted from Finnish nationwide health-care registers...
July 11, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28682476/plasma-levels-of-hepatocyte-growth-factor-and-placental-growth-factor-predict-mortality-in-a-general-population-a-prospective-cohort-study
#15
K Santalahti, A Havulinna, M Maksimow, T Zeller, S Blankenberg, A Vehtari, H Joensuu, S Jalkanen, V Salomaa, M Salmi
BACKGROUND: Circulating levels of growth factors involved in leucocyte production and angiogenesis could be indicative of underlying aberrations of tissue homeostasis and therefore be utilized as predictors of risk for all-cause cardiovascular disease (CVD) or cancer mortality. METHODS: Baseline plasma levels of a range of growth factors were measured in two cohorts of the population-based FINRISK study (1997 Discovery cohort, N = 8444, aged 25-74; 2002 Replication cohort, N = 2951, aged 51-74 years) using a multiplexed bead array methodology and ELISA...
October 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28679932/the-guiding-role-of-a-paradigm-in-informatics-education-and-research
#16
Kaija Saranto, Ulla-Mari Kinnunen, Eija Kivekäs, Juhamatti Huusko, Sirpa Kuusisto-Niemi
This study presents the current status of a paradigm used in informatics education and research in the health and human services fields. The aim is to synthesize the research focuses of students' theses and evaluate the current situation. The paradigm models informatics research. The research focus, questions and applied research methods were coded for 144 Master's degree theses. Based on the results, the theses could easily be coded for the paradigm concepts and research focuses. The most often used concept was data, which was connected to steering and organizing information management in work processes...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28670215/using-scenario-based-training-to-promote-information-literacy-among-on-call-consultant-pediatricians
#17
Jonas Pettersson, Emil Bjorkander, Sirpa Bark, Daniel Holmgren, Per Wekell
BACKGROUND: Traditionally, teaching hospital staff to search for medical information relies heavily on educator-defined search methods. In contrast, the authors describe our experiences using real-time scenarios to teach on-call consultant pediatricians information literacy skills as part of a two-year continuing professional development program. CASE PRESENTATION: Two information-searching workshops were held at Sahlgrenska University Hospital in Gothenburg, Sweden...
July 2017: Journal of the Medical Library Association: JMLA
https://www.readbyqxmd.com/read/28669759/sirpa-inhibited-marrow-derived-macrophages-engorge-accumulate-and-differentiate-in-antibody-targeted-regression-of-solid-tumors
#18
Cory M Alvey, Kyle R Spinler, Jerome Irianto, Charlotte R Pfeifer, Brandon Hayes, Yuntao Xia, Sangkyun Cho, P C P Dave Dingal, Jake Hsu, Lucas Smith, Manu Tewari, Dennis E Discher
Marrow-derived macrophages are highly phagocytic, but whether they can also traffic into solid tumors and engulf cancer cells is questionable, given the well-known limitations of tumor-associated macrophages (TAMs). Here, SIRPα on macrophages from mouse and human marrow was inhibited to block recognition of its ligand, the "marker of self" CD47 on all other cells. These macrophages were then systemically injected into mice with fluorescent human tumors that had been antibody targeted. Within days, the tumors regressed, and single-cell fluorescence analyses showed that the more the macrophages engulfed, the more they accumulated within regressing tumors...
July 24, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28599121/head-or-brain-injuries-and-alzheimer-s-disease-a-nested-case-control-register-study
#19
Anna-Maija Tolppanen, Heidi Taipale, Sirpa Hartikainen
INTRODUCTION: Many previous studies have been limited by self- or proxy-reported injury or short follow-up. We investigated whether head or brain injuries are associated with Alzheimer's disease (AD), possible modifying factors and dose-response relationship. METHODS: Nested register-based case-control study of all community dwellers who received clinically verified AD diagnosis in Finland in 2005 to 2011 (n = 70,719) and one to four matched controls for each case (n of controls = 282,862)...
June 7, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28577224/long-term-use-of-proton-pump-inhibitors-among-community-dwelling-persons-with-and-without-alzheimer-s-disease
#20
Heidi Juntunen, Heidi Taipale, Antti Tanskanen, Anna-Maija Tolppanen, Jari Tiihonen, Sirpa Hartikainen, Miia Tiihonen
PURPOSE: The aim of this study is to determine the prevalence of use and long-term use (≥180 days) of proton pump inhibitors (PPIs) and associated factors among community-dwellers with and without Alzheimer's disease (AD). METHODS: MEDALZ cohort encompassed all persons who received a verified diagnosis of AD in Finland during the years 2005-2011 and their age-, sex-, and region of residence-matched comparison persons, including 69,353 persons with and 69,353 persons without AD...
September 2017: European Journal of Clinical Pharmacology
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