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https://www.readbyqxmd.com/read/28424246/enteropathy-associated-t-cell-lymphoma-subtypes-are-characterized-by-loss-of-function-of-setd2
#1
Andrea B Moffitt, Sarah L Ondrejka, Matthew McKinney, Rachel E Rempel, John R Goodlad, Chun Huat Teh, Sirpa Leppa, Susanna Mannisto, Panu E Kovanen, Eric Tse, Rex K H Au-Yeung, Yok-Lam Kwong, Gopesh Srivastava, Javeed Iqbal, Jiayu Yu, Kikkeri Naresh, Diego Villa, Randy D Gascoyne, Jonathan Said, Magdalena B Czader, Amy Chadburn, Kristy L Richards, Deepthi Rajagopalan, Nicholas S Davis, Eileen C Smith, Brooke C Palus, Tiffany J Tzeng, Jane A Healy, Patricia L Lugar, Jyotishka Datta, Cassandra Love, Shawn Levy, David B Dunson, Yuan Zhuang, Eric D Hsi, Sandeep S Dave
Enteropathy-associated T cell lymphoma (EATL) is a lethal, and the most common, neoplastic complication of celiac disease. Here, we defined the genetic landscape of EATL through whole-exome sequencing of 69 EATL tumors. SETD2 was the most frequently silenced gene in EATL (32% of cases). The JAK-STAT pathway was the most frequently mutated pathway, with frequent mutations in STAT5B as well as JAK1, JAK3, STAT3, and SOCS1 We also identified mutations in KRAS, TP53, and TERT Type I EATL and type II EATL (monomorphic epitheliotropic intestinal T cell lymphoma) had highly overlapping genetic alterations indicating shared mechanisms underlying their pathogenesis...
April 19, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28415993/moving-to-business-changes-in-physical-activity-and-sedentary-behavior-after-multilevel-intervention-in-small-and-medium-size-workplaces
#2
Minna Aittasalo, Matleena Livson, Sirpa Lusa, Ahti Romo, Henri Vähä-Ypyä, Kari Tokola, Harri Sievänen, Ari Mänttäri, Tommi Vasankari
BACKGROUND: Regular physical activity (PA) promotes and excessive sedentary behavior (SB) deteriorates health. Yet the Finnish working-aged population spends most of the day sitting. A 1-year Moving To Business (MTB) -intervention supported small and medium-size workplaces to combat sedentariness. This paper reports the changes in employees' PA and SB from before MTB (baseline) to 1 year after baseline (follow-up). METHODS: Twelve workplaces with a total of 396 employees participated...
April 17, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28414159/in-vitro-toxicological-effects-of-zinc-containing-nanoparticles-with-different-physico-chemical-properties
#3
Oskari Uski, Tiina Torvela, Olli Sippula, Tommi Karhunen, Hanna Koponen, Sirpa Peräniemi, Pasi Jalava, Mikko Happo, Jorma Jokiniemi, Maija-Riitta Hirvonen, Anna Lähde
Nanomaterials (NM) exhibit novel physicochemical properties that determine their interaction with biological substrates and processes. Recent nano-technological advances are leading to wide usage of metallic nanoparticles (NPs) in various fields. However, the increasing use of NPs has led to their release into environment and the toxicity of NPs on human health has become a concern. Moreover, there are inadvertently generated metallic NPs which are formed during various human activities (e.g. metal processing and energy production)...
April 14, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28396328/risk-of-pneumonia-associated-with-incident-benzodiazepine-use-among-community-dwelling-adults-with-alzheimer-disease
#4
Heidi Taipale, Anna-Maija Tolppanen, Marjaana Koponen, Antti Tanskanen, Piia Lavikainen, Reijo Sund, Jari Tiihonen, Sirpa Hartikainen
BACKGROUND: Knowledge regarding whether benzodiazepines and similarly acting non-benzodiazepines (Z-drugs) are associated with an increased risk of pneumonia among older adults is lacking. We sought to investigate this association among community-dwelling adults with Alzheimer disease, a condition in which both sedative/hypnotic use and pneumonia are common. METHODS: We obtained data on all community-dwelling adults with a recent diagnosis of Alzheimer disease in Finland (2005-2011) from the Medication use and Alzheimer disease (MEDALZ) cohort, which incorporates national registry data on prescriptions, reimbursement, hospital discharges and causes of death...
April 10, 2017: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/28386104/intubation-free-in-vivo-imaging-of-the-tracheal-mucosa-using-two-photon-microscopy
#5
Tibor Z Veres, Tamás Kopcsányi, Marko Tirri, Armin Braun, Masayuki Miyasaka, Ronald N Germain, Sirpa Jalkanen, Marko Salmi
The mucosal layer of conducting airways is the primary tissue exposed to inhaled microorganisms, allergens and pollutants. We developed an in vivo two-photon microscopic approach that allows performing dynamic imaging studies in the mouse trachea, which is a commonly used in vivo model of human small-diameter bronchi. By providing stabilized access to the tracheal mucosa without intubation, our setup uniquely allows dynamic in vivo imaging of mucociliary clearance and steady-state immune cell behavior within the complex airway mucosal tissue...
April 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28383029/genetic-mutation-and-exosome-signature-of-human-papilloma-virus-associated-oropharyngeal-cancer
#6
Anbarasu Kannan, Kate L Hertweck, Julie V Philley, Robert B Wells, Santanu Dasgupta
Human papilloma virus-16 (HPV-16) associated oropharyngeal cancer (HPVOPC) is increasing alarmingly in the United States. We performed whole genome sequencing of a 44 year old, male HPVOPC subject diagnosed with moderately differentiated tonsillar carcinoma. We identified new somatic mutation in MUC16 (A.k.a. CA-125), MUC12, MUC4, MUC6, MUC2, SIRPA, HLA-DRB1, HLA-A and HLA-B molecules. Increased protein expression of MUC16, SIRPA and decreased expression of HLA-DRB1 was further demonstrated in this HPVOPC subject and an additional set of 15 HPVOPC cases...
April 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28375212/faecalibacterium-prausnitzii-treatment-improves-hepatic-health-and-reduces-adipose-tissue-inflammation-in-high-fat-fed-mice
#7
Eveliina Munukka, Anniina Rintala, Raine Toivonen, Matts Nylund, Baoru Yang, Anna Takanen, Arno Hänninen, Jaana Vuopio, Pentti Huovinen, Sirpa Jalkanen, Satu Pekkala
Faecalibacterium prausnitzii is considered as one of the most important bacterial indicators of a healthy gut. We studied the effects of oral F. prausnitzii treatment on high-fat fed mice. Compared to the high-fat control mice, F. prausnitzii-treated mice had lower hepatic fat content, aspartate aminotransferase and alanine aminotransferase, and increased fatty acid oxidation and adiponectin signaling in liver. Hepatic lipidomic analyses revealed decreases in several species of triacylglycerols, phospholipids and cholesteryl esters...
April 4, 2017: ISME Journal
https://www.readbyqxmd.com/read/28339536/successful-nutrition-policy-improvement-of-vitamin-d-intake-and-status-in-finnish-adults-over-the-last-decade
#8
Susanna Raulio, Iris Erlund, Satu Männistö, Sirpa Sarlio-Lähteenkorva, Jouko Sundvall, Heli Tapanainen, Erkki Vartiainen, Suvi M Virtanen
Due to vitamin D intake below recommendation (10 µg/day) and low (<50 nmol/l) serum 25-hydroxycholecalciferol (25(OH)D) concentration in Finnish population, the fortification of liquid dairy products with 0.5 µg vitamin D/100 g and fat spreads with 10 µg/100 g started in Finland in December 2002. In 2010, the fortification recommendation was doubled. The aim of this study was to investigate whether the vitamin D intake and status have improved among Finnish adults as a consequence of these nutrition policy actions...
October 6, 2016: European Journal of Public Health
https://www.readbyqxmd.com/read/28339338/fertility-treatments-among-female-cancer-survivors-giving-birth-a-finnish-register-based-study
#9
Johanna Melin, Laura Madanat-Harjuoja, Sirpa Heinävaara, Nea Malila, Mika Gissler, Aila Tiitinen
BACKGROUND: Long-term survival rates for most types of childhood cancers have improved dramatically over the past decades. However, because of advances in multimodality treatments, cancer survivors nowadays more often face long-term complications, including diminished gonadal and reproductive function. The aim of this study was to identify whether the use of fertility treatments among early onset (0-34 years) cancer survivors giving birth differed from that among siblings giving birth and to identify the subgroups of cancer survivors that were most likely to require fertility treatments...
March 24, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28331284/a-retrospective-study-comparing-outcomes-of-primary-rhegmatogenous-retinal-detachment-repair-by-scleral-buckling-and-pars-plana-vitrectomy-in-finland
#10
Sari Sahanne, Raimo Tuuminen, Jari Haukka, Sirpa Loukovaara
BACKGROUND: Rhegmatogenous retinal detachment (RRD) is the most common form of retinal detachment and an ophthalmic emergency. Here, we compared outcomes of primary RRD eyes operated with conventional scleral buckling (SB) with cryoretinopexy to those operated with standard pars plana vitrectomy (PPV). METHODS: This is an institutional, retrospective, register-based, observational, comparative study. Based on the surgical procedure, 319 eyes of 319 patients were divided into two groups: SB plus cryotherapy (n=50) and PPV (n=269)...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28327550/significant-role-of-collagen-xvii-and-integrin-%C3%AE-4-in-migration-and-invasion-of-the-less-aggressive-squamous-cell-carcinoma-cells
#11
Jyri M Moilanen, Stefanie Löffek, Nina Kokkonen, Sirpa Salo, Juha P Väyrynen, Tiina Hurskainen, Aki Manninen, Pilvi Riihilä, Ritva Heljasvaara, Claus-Werner Franzke, Veli-Matti Kähäri, Tuula Salo, Markus J Mäkinen, Kaisa Tasanen
Collagen XVII and integrin α6β4 have well-established roles as epithelial adhesion molecules. Their binding partner laminin 332 as well as integrin α6β4 are largely recognized to promote invasion and metastasis in various cancers, and collagen XVII is essential for the survival of colon and lung cancer stem cells. We have studied the expression of laminin γ2, collagen XVII and integrin β4 in tissue microarray samples of squamous cell carcinoma (SCC) and its precursors, actinic keratosis and Bowen's disease...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28293474/transition-from-oxcarbazepine-to-eslicarbazepine-acetate-a-single-center-study
#12
Jussi Mäkinen, Sirpa Rainesalo, Jukka Peltola
OBJECTIVES: There is limited clinical evidence for comparison between oxcarbazepine (OXC) and eslicarbazepine acetate (ESL) in terms of tolerability, or how to execute the change from OXC to ESL. We report the process of transitioning patients with focal epilepsy from previous OXC treatment to ESL due to tolerability problems. The rationale for change from OXC is reported, and the outcome with respective to this rationale is analyzed in terms of tolerability and efficacy. MATERIALS AND METHODS: The subjects were transitioned overnight from OXC to ESL in a hospital inpatient setting...
March 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28282542/the-effect-of-newer-antiepileptic-drugs-in-combination-therapy
#13
Jussi Mäkinen, Sirpa Rainesalo, Jani Raitanen, Jukka Peltola
PURPOSE: To assess the impact of the new AEDs on overall outcome for patients with epilepsy. METHODS: In 2004, the effect of combination therapy on seizure frequency in adult patients with focal epilepsy was evaluated in a cross-sectional study in our center. We repeated this analysis ten years and eight new antiepileptic drugs (AED) later. RESULTS: In 2014, a higher percentage of patients with polytherapy (117 out of 396; 30%) were seizure-free compared with the original analysis (22%) (p=0...
March 2, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28278245/regional-changes-in-psychotropic-use-among-finnish-persons-with-newly-diagnosed-alzheimer-s-disease-in-2005-2011
#14
Anna-Maija Tolppanen, Ari Voutilainen, Heidi Taipale, Antti Tanskanen, Piia Lavikainen, Marjaana Koponen, Jari Tiihonen, Sirpa Hartikainen
OBJECTIVES: To describe and compare temporal changes in prevalence and incidence of psychotropic use (antipsychotics, antidepressants and benzodiazepines and related drugs; BZDRs) in persons with newly diagnosed Alzheimer's disease (AD) between university hospital districts of Finland during 2005-2011. METHODS: The MEDALZ study includes all community-dwellers of Finland who received a clinically verified AD diagnosis in 2005-2011 (N = 70,718). Prevalent and incident use of psychotropics among those who had received AD diagnosis less than one year ago were compared in 2005-2011...
2017: PloS One
https://www.readbyqxmd.com/read/28274328/risk-of-alzheimer-s-disease-among-users-of-postmenopausal-hormone-therapy-a-nationwide-case-control-study
#15
Bushra Imtiaz, Heidi Taipale, Antti Tanskanen, Miia Tiihonen, Miia Kivipelto, Anna-Mari Heikkinen, Jari Tiihonen, Hilkka Soininen, Sirpa Hartikainen, Anna-Maija Tolppanen
OBJECTIVE: To examine the association between postmenopausal hormone therapy (HT) and Alzheimer's disease (AD). METHODS: Medicine and Alzheimer's disease (MEDALZ) is a nested case-control study of the entire Finnish population with clinically verified AD from 2005 to 2011 and up to 4 matched controls per case. This study comprises 230,580 women (46,117 cases and 184,463 controls). Data on HT use from 1995 to 2011 was extracted from the national prescription register using following ATC codes: G03C (estrogen), G03D (progestogen) and G03F (estrogen and progestogen in combination)...
April 2017: Maturitas
https://www.readbyqxmd.com/read/28271611/nlrp3-inflammasome-activation-is-associated-with-proliferative-diabetic-retinopathy
#16
Sirpa Loukovaara, Niina Piippo, Kati Kinnunen, Maria Hytti, Kai Kaarniranta, Anu Kauppinen
PURPOSE: Innate immunity and dysregulation of inflammatory processes play a role in vascular diseases like atherosclerosis or diabetes. Nucleotide-binding domain and Leucine-rich repeat Receptor containing a Pyrin domain 3 (NLRP3) inflammasomes are pro-inflammatory signalling complexes that were found in 2002. In addition to pathogens and other extracellular threats, they can be activated by various endogenous danger signals. The purpose of this study was to find out whether NLRP3 activation occurs in patients with sight-threatening forms of diabetic retinopathy (DR)...
March 8, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28268219/treg-cells-protect-dopaminergic-neurons-against-mpp-neurotoxicity-via-cd47-sirpa-interaction
#17
Yan Huang, Zhan Liu, Bei-Bei Cao, Yi-Hua Qiu, Yu-Ping Peng
BACKGROUND/AIMS: Regulatory T (Treg) cells have been associated with neuroprotection by inhibiting microglial activation in animal models of Parkinson's disease (PD), a progressive neurodegenerative disease characterized by dopaminergic neuronal loss in the nigrostriatal system. Herein, we show that Treg cells directly protect dopaminergic neurons against 1-methyl-4-phenylpyridinium (MPP+) neurotoxicity via an interaction between the two transmembrane proteins CD47 and signal regulatory protein α (SIRPA)...
March 7, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28251930/amine-oxidase-activity-regulates-the-development-of-pulmonary-fibrosis
#18
Fumiko Marttila-Ichihara, Kati Elima, Kaisa Auvinen, Tibor Z Veres, Pia Rantakari, Christopher Weston, Masayuki Miyasaka, David Adams, Sirpa Jalkanen, Marko Salmi
In pulmonary fibrosis, an inflammatory reaction and differentiation of myofibroblasts culminate in pathologic deposition of collagen. Amine oxidase copper containing-3 (AOC3) is a cell-surface expressed oxidase that regulates leukocyte extravasation. Here we analyzed the potential role of AOC3 using gene-modified and inhibitor-treated mice in a bleomycin-induced pulmonary fibrosis model. Inflammation and fibrosis of lungs were assessed by histologic, flow cytometric, and quantitative PCR analysis. AOC3-deficient mice showed a 30-50% reduction in fibrosis, collagen synthesis, numbers of myofibroblasts, and accumulation of CD4(+) lymphocytes, NK T cells, macrophages, and type 2 innate lymphoid cells compared with wild-type control mice...
March 1, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28200017/preventive-oral-health-intervention-among-old-home-care-clients
#19
Annamari Nihtilä, Eveliina Tuuliainen, Kaija Komulainen, Kirsi Autonen-Honkonen, Irma Nykänen, Sirpa Hartikainen, Riitta Ahonen, Miia Tiihonen, Anna Liisa Suominen
No abstract text is available yet for this article.
February 14, 2017: Age and Ageing
https://www.readbyqxmd.com/read/28186141/spatial-variations-in-the-molecular-diversity-of-dissolved-organic-matter-in-water-moving-through-a-boreal-forest-in-eastern-finland
#20
Jun'ichiro Ide, Mizue Ohashi, Katsutoshi Takahashi, Yuko Sugiyama, Sirpa Piirainen, Pirkko Kortelainen, Nobuhide Fujitake, Keitaro Yamase, Nobuhito Ohte, Mina Moritani, Miyako Hara, Leena Finér
Dissolved organic matter (DOM) strongly affects water quality within boreal forest ecosystems. However, how the quality of DOM itself changes spatially is not well understood. In this study, to examine how the diversity of DOM molecules varies in water moving through a boreal forest, the number of DOM molecules in different water samples, i.e., rainwater, throughfall, soil water, groundwater, and stream water was determined using Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) in Norway spruce and Scots pine stands in eastern Finland during May and June 2010...
February 10, 2017: Scientific Reports
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