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https://www.readbyqxmd.com/read/29143367/risk-of-death-associated-with-new-benzodiazepine-use-among-persons-with-alzheimer-disease-a-matched-cohort-study
#1
Laura Saarelainen, Anna-Maija Tolppanen, Marjaana Koponen, Antti Tanskanen, Jari Tiihonen, Sirpa Hartikainen, Heidi Taipale
OBJECTIVE: To investigate the risk of death associated with new benzodiazepine and related drug (BZDR) use in a nationwide cohort of persons with Alzheimer disease (AD). METHODS: The register-based MEDALZ cohort, including all community-dwelling Finns diagnosed with AD during 2005 to 2011 (n = 70 718), was used. Clinically verified AD diagnoses were obtained from the Special Reimbursement Register. Drug use periods were modeled from BZDR purchases, derived from the Prescription Register...
November 15, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29097701/two-missense-mutations-in-kcnq1-cause-pituitary-hormone-deficiency-and-maternally-inherited-gingival-fibromatosis
#2
Johanna Tommiska, Johanna Känsäkoski, Lasse Skibsbye, Kirsi Vaaralahti, Xiaonan Liu, Emily J Lodge, Chuyi Tang, Lei Yuan, Rainer Fagerholm, Jørgen K Kanters, Päivi Lahermo, Mari Kaunisto, Riikka Keski-Filppula, Sanna Vuoristo, Kristiina Pulli, Tapani Ebeling, Leena Valanne, Eeva-Marja Sankila, Sirpa Kivirikko, Mitja Lääperi, Filippo Casoni, Paolo Giacobini, Franziska Phan-Hug, Tal Buki, Manuel Tena-Sempere, Nelly Pitteloud, Riitta Veijola, Marita Lipsanen-Nyman, Kari Kaunisto, Patrice Mollard, Cynthia L Andoniadou, Joel A Hirsch, Markku Varjosalo, Thomas Jespersen, Taneli Raivio
Familial growth hormone deficiency provides an opportunity to identify new genetic causes of short stature. Here we combine linkage analysis with whole-genome resequencing in patients with growth hormone deficiency and maternally inherited gingival fibromatosis. We report that patients from three unrelated families harbor either of two missense mutations, c.347G>T p.(Arg116Leu) or c.1106C>T p.(Pro369Leu), in KCNQ1, a gene previously implicated in the long QT interval syndrome. Kcnq1 is expressed in hypothalamic GHRH neurons and pituitary somatotropes...
November 3, 2017: Nature Communications
https://www.readbyqxmd.com/read/29078283/humanized-mouse-model-supports-development-function-and-tissue-residency-of-human-natural-killer-cells
#3
Dietmar Herndler-Brandstetter, Liang Shan, Yi Yao, Carmen Stecher, Valerie Plajer, Melanie Lietzenmayer, Till Strowig, Marcel R de Zoete, Noah W Palm, Jie Chen, Catherine A Blish, Davor Frleta, Cagan Gurer, Lynn E Macdonald, Andrew J Murphy, George D Yancopoulos, Ruth R Montgomery, Richard A Flavell
Immunodeficient mice reconstituted with a human immune system represent a promising tool for translational research as they may allow modeling and therapy of human diseases in vivo. However, insufficient development and function of human natural killer (NK) cells and T cell subsets limit the applicability of humanized mice for studying cancer biology and therapy. Here, we describe a human interleukin 15 (IL15) and human signal regulatory protein alpha (SIRPA) knock-in mouse on a Rag2(-/-)Il2rg(-/-) background (SRG-15)...
October 25, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29065711/vascular-adhesion-protein-1-a-cell-surface-amine-oxidase-in-translation
#4
Sirpa Jalkanen, Marko Salmi
SIGNIFICANCE: Vascular adhesion protein-1 (VAP-1) is an ectoenzyme, which oxidates primary amines in a reaction producing also hydrogen peroxide. VAP-1 on the blood vessel endothelium regulates leukocyte extravasation from the blood into tissues under physiological and pathological conditions. Recent advances: Inhibition of VAP-1 by neutralizing antibodies and by several novel small molecule enzyme inhibitors interferes with leukocyte trafficking and alleviates inflammation in many experimental models...
October 25, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29056311/an-international-prospective-cohort-study-of-mobile-phone-users-and-health-cosmos-factors-affecting-validity-of-self-reported-mobile-phone-use
#5
Mireille B Toledano, Anssi Auvinen, Giorgio Tettamanti, Yang Cao, Maria Feychting, Anders Ahlbom, Karin Fremling, Sirpa Heinävaara, Katja Kojo, Gemma Knowles, Rachel B Smith, Joachim Schüz, Christoffer Johansen, Aslak Harbo Poulsen, Isabelle Deltour, Roel Vermeulen, Hans Kromhout, Paul Elliott, Lena Hillert
This study investigates validity of self-reported mobile phone use in a subset of 75 993 adults from the COSMOS cohort study. Agreement between self-reported and operator-derived mobile call frequency and duration for a 3-month period was assessed using Cohen's weighted Kappa (κ). Sensitivity and specificity of both self-reported high (≥10 calls/day or ≥4h/week) and low (≤6 calls/week or <30min/week) mobile phone use were calculated, as compared to operator data. For users of one mobile phone, agreement was fair for call frequency (κ=0...
September 20, 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/29055031/impact-of-gender-neutral-or-girls-only-vaccination-against-human-papillomavirus-results-of-a-community-randomized-clinical-trial-i
#6
Matti Lehtinen, Anna Söderlund-Strand, Simopekka Vänskä, Tapio Luostarinen, Tiina Eriksson, Kari Natunen, Dan Apter, Iacopo Baussano, Katja Harjula, Mari Hokkanen, Marjo Kuortti, Johanna Palmroth, Tiina Petäjä, Eero Pukkala, Sirpa Rekonen, Mari Siitari-Mattila, Heljä-Marja Surcel, Leena Tuomivaara, Jorma Paavonen, Joakim Dillner, Gary Dubin, Geoffrey Garnett
Human papillomavirus (HPV) vaccine is efficacious but the real-life effectiveness of gender-neutral and girls-only vaccination strategies is unknown. We report a community-randomized trial on the protective effectiveness [(PE) = vaccine efficacy (VE) + herd effect (HE)] of the two strategies among females in virtually HPV vaccination naïve population. We randomized 33 Finnish communities into Arm A) gender-neutral vaccination with AS04-adjuvanted HPV16/18 vaccine (11 communities), Arm B) HPV vaccination of girls and hepatitis B-virus (HBV) vaccination of boys (11 communities) or Arm C) gender-neutral HBV vaccination (11 communities)...
October 21, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29040144/surgical-treatment-of-dentofacial-deformities-caused-by-juvenile-idiopathic-arthritis
#7
Patricia Stoor, Zlatan Hodzic, Sirpa Arte
The purpose of our retrospective study was to evaluate the results of orthognathic treatment, distraction osteogenesis, and/or prosthetic reconstruction of the temporomandibular joints in patients with juvenile idiopathic arthritis (JIA).Twelve patients with severely affected temporomandibular joints (TMJs) and reduced ramus height were treated with mandibular advancement with orthognathic surgery (11) and additional bilateral or unilateral mandibular ramus distraction (3) or additional bilateral or unilateral prosthetic reconstruction of the TMJ (3)...
October 16, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29025166/is-alzheimer-s-disease-associated-with-previous-opioid-use
#8
Heidi Taipale, Aleksi Hamina, Pasi Lampela, Antti Tanskanen, Jari Tiihonen, Niina Karttunen, Anna-Maija Tolppanen, Sirpa Hartikainen
Objective: We investigated whether opioid use, duration of use, and cumulative dose are associated with an increased risk of Alzheimer's disease (AD). Methods: A Finnish nationwide nested case-control study, MEDALZ, included 70,718 individuals with AD and up to four age-, sex-, and region of residence-matched comparison individuals. The cohort included all Finnish persons with a clinically verified AD diagnosis during 2005 to 2011; the mean age was 80 years (SD = 7 years), and 65% were women...
August 28, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29020299/lifestyle-in-population-based-colorectal-cancer-screening-over-2-year-follow-up
#9
Sanni Helander, Sirpa Heinävaara, Tytti Sarkeala, Nea Malila
Background: Colorectal cancer (CRC) screening may cause changes in health-related lifestyle. In 2010, Finnish Mass Screening Registry began a study on psychosocial effects of CRC screening. This article examines whether there are differential developments in self-reported lifestyle at ages 59-61 years among CRC screening invitees and non-contacted controls. Methods: A population-based random sample of 10 648 Finnish adults born in 1951 and living in the municipalities voluntary involved in the CRC screening programme were sent a lifestyle questionnaire in 2010...
September 15, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/28985567/genetic-and-functional-drivers-of-diffuse-large-b%C3%A2-cell-lymphoma
#10
Anupama Reddy, Jenny Zhang, Nicholas S Davis, Andrea B Moffitt, Cassandra L Love, Alexander Waldrop, Sirpa Leppa, Annika Pasanen, Leo Meriranta, Marja-Liisa Karjalainen-Lindsberg, Peter Nørgaard, Mette Pedersen, Anne O Gang, Estrid Høgdall, Tayla B Heavican, Waseem Lone, Javeed Iqbal, Qiu Qin, Guojie Li, So Young Kim, Jane Healy, Kristy L Richards, Yuri Fedoriw, Leon Bernal-Mizrachi, Jean L Koff, Ashley D Staton, Christopher R Flowers, Ora Paltiel, Neta Goldschmidt, Maria Calaminici, Andrew Clear, John Gribben, Evelyn Nguyen, Magdalena B Czader, Sarah L Ondrejka, Angela Collie, Eric D Hsi, Eric Tse, Rex K H Au-Yeung, Yok-Lam Kwong, Gopesh Srivastava, William W L Choi, Andrew M Evens, Monika Pilichowska, Manju Sengar, Nishitha Reddy, Shaoying Li, Amy Chadburn, Leo I Gordon, Elaine S Jaffe, Shawn Levy, Rachel Rempel, Tiffany Tzeng, Lanie E Happ, Tushar Dave, Deepthi Rajagopalan, Jyotishka Datta, David B Dunson, Sandeep S Dave
Diffuse large B cell lymphoma (DLBCL) is the most common form of blood cancer and is characterized by a striking degree of genetic and clinical heterogeneity. This heterogeneity poses a major barrier to understanding the genetic basis of the disease and its response to therapy. Here, we performed an integrative analysis of whole-exome sequencing and transcriptome sequencing in a cohort of 1,001 DLBCL patients to comprehensively define the landscape of 150 genetic drivers of the disease. We characterized the functional impact of these genes using an unbiased CRISPR screen of DLBCL cell lines to define oncogenes that promote cell growth...
October 5, 2017: Cell
https://www.readbyqxmd.com/read/28978923/immunological-tumor-status-may-predict-response-to-neoadjuvant-chemotherapy-and-outcome-after-radical-cystectomy-in-bladder-cancer
#11
Minna Tervahartiala, Pekka Taimen, Tuomas Mirtti, Ilmari Koskinen, Thorsten Ecke, Sirpa Jalkanen, Peter J Boström
Bladder cancer (BC) is the ninth most common cancer worldwide. Radical cystectomy (RC) with neoadjuvant chemotherapy (NAC) is recommended for muscle-invasive BC. The challenge of the neoadjuvant approach relates to challenges in selection of patients to chemotherapy that are likely to respond to the treatment. To date, there are no validated molecular markers or baseline clinical characteristics to identify these patients. Different inflammatory markers, including tumor associated macrophages with their plastic pro-tumorigenic and anti-tumorigenic functions, have extensively been under interests as potential prognostic and predictive biomarkers in different cancer types...
October 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28976790/phosphatidylinositol-3-kinase-inhibition-by-copanlisib-in-relapsed-or-refractory-indolent-lymphoma
#12
Martin Dreyling, Armando Santoro, Luigina Mollica, Sirpa Leppä, George A Follows, Georg Lenz, Won Seog Kim, Arnon Nagler, Panayiotis Panayiotidis, Judit Demeter, Muhit Özcan, Marina Kosinova, Krimo Bouabdallah, Franck Morschhauser, Don A Stevens, David Trevarthen, Marius Giurescu, Lisa Cupit, Li Liu, Karl Köchert, Henrik Seidel, Carol Peña, Shuxin Yin, Florian Hiemeyer, Jose Garcia-Vargas, Barrett H Childs, Pier Luigi Zinzani
Purpose Phosphatidylinositol 3-kinase (PI3K) signaling is critical for the proliferation and survival of malignant B cells. Copanlisib, a pan-class I PI3K inhibitor with predominant activity against PI3K-α and -δ isoforms, has demonstrated efficacy and a manageable safety profile in patients with indolent lymphoma. Patients and Methods In this phase II study, 142 patients with relapsed or refractory indolent lymphoma after two or more lines of therapy were enrolled to receive copanlisib 60 mg intravenously on days 1, 8, and 15 of a 28-day cycle...
October 4, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28968301/diminished-coagulation-capacity-assessed-by-calibrated-automated-thrombography-during-acute-puumala-hantavirus-infection
#13
Sirpa M Koskela, Lotta Joutsi-Korhonen, Satu M Mäkelä, Heini Huhtala, Antti I Vaheri, Ilkka Pörsti, Jukka T Mustonen, Outi K Laine
: Coagulation abnormalities are associated with Puumala-virus-induced hemorrhagic fever with renal syndrome (PUUV-HFRS). We evaluated the coagulation capacity of plasma during acute PUUV-HFRS by measuring thrombin generation using calibrated automated thrombography (CAT). The study cohort comprised 27 prospectively collected, consecutive, hospital-treated patients with acute PUUV infection. Blood samples were drawn in the acute phase and at the control visit approximately 5 weeks later. To evaluate thrombin generation, the lag time of initiation, endogenous thrombin potential (ETP), and peak and time to peak thrombin concentration were assessed by CAT in platelet poor plasma without corn trypsin inhibitor...
September 28, 2017: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/28942994/impact-of-organized-and-opportunistic-pap-testing-on-the-risk-of-cervical-cancer-in-young-women-a-case-control-study-from-finland
#14
Petra Makkonen, Sirpa Heinävaara, Tytti Sarkeala, Ahti Anttila
OBJECTIVE: Effectiveness of organized cervical cancer screening has been shown in several studies. However, screening among women aged <25years has been suggested to have little or no impact on the risk of cervical cancer. Also the significance of opportunistic testing in preventing cervical cancer is unclear. The aim of this study was to clarify the effect of opportunistic testing and organized screening on the risk of cervical cancer among young Finnish women. METHODS: In the Finnish Cancer Registry there were 284 cervical cancer cases diagnosed and tested below the age of 40 in 2004-2009...
September 21, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28940566/anticholinergic-burden-and-dry-mouth-among-finnish-community-dwelling-older-adults
#15
Antti Tiisanoja, Anna-Maija Syrjälä, Kaija Komulainen, Pasi Lampela, Sirpa Hartikainen, Heidi Taipale, Matti Knuuttila, Pekka Ylöstalo
OBJECTIVE: The aim was to study whether the anticholinergic burden of drugs is related to xerostomia and salivary secretion among community-dwelling elderly people. BACKGROUND: Anticholinergic drugs have been shown to be a risk factor for dry mouth, but little is known about the effects of cumulative exposure to anticholinergic drugs measured by anticholinergic burden on salivary secretion or xerostomia. METHODS: The study population consisted of 152 community-dwelling, dentate, non-smoking, older people from the Oral Health GeMS study...
September 21, 2017: Gerodontology
https://www.readbyqxmd.com/read/28886089/drug-exposure-in-register-based-research-an-expert-opinion-based-evaluation-of-methods
#16
Antti Tanskanen, Heidi Taipale, Marjaana Koponen, Anna-Maija Tolppanen, Sirpa Hartikainen, Riitta Ahonen, Jari Tiihonen
BACKGROUND: In register-based pharmacoepidemiological studies, construction of drug exposure periods from drug purchases is a major methodological challenge. Various methods have been applied but their validity is rarely evaluated. Our objective was to conduct an expert-opinion based evaluation of the correctness of drug use periods produced by different methods. METHODS: Drug use periods were calculated with three fixed methods: time windows, assumption of one Defined Daily Dose (DDD) per day and one tablet per day, and with PRE2DUP that is based on modelling of individual drug purchasing behavior...
2017: PloS One
https://www.readbyqxmd.com/read/28857986/craniofacial-and-dental-features-in-six-children-with-cherubism
#17
Patricia Stoor, Anni Suomalainen, W Kemola, Sirpa Arte
Cherubism is an autosomal-dominant benign bone disorder, characterized by fibro-osseous lesions in the mandible and maxilla commonly caused by mutations in the SH3-binding protein 2-gene. The purpose of the authors' study was to analyze craniofacial and dental features of children diagnosed with cherubism, describe their treatment, and assess their dental age compared with norms for Finnish children. Six children were diagnosed, followed up and treated due to dental and skeletal disorders caused by cherubsim...
October 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28851562/viral-load-affects-the-immune-response-to-hbv-in-mice-with-humanized-immune-system-and-liver
#18
Mathilde Dusséaux, Guillemette Masse-Ranson, Sylvie Darche, James Ahodantin, Yan Li, Oriane Fiquet, Elodie Beaumont, Pierrick Moreau, Lise Rivière, Christine Neuveut, Patrick Soussan, Philippe Roingeard, Dina Kremsdorf, James P Di Santo, Helene Strick-Marchand
BACKGROUND & AIMS: Hepatitis B virus (HBV) infects hepatocytes, but the mechanisms of the immune response against the virus, and how it affects disease progression, are unclear. METHODS: We performed studies with BALB/c Rag2(-/-)Il2rg(-/-)Sirpa(NOD)Alb-uPA(tg/tg) mice, stably engrafted with human hepatocytes (HUHEP) with or without a human immune system (HIS). HUHEP and HIS-HUHEP mice were given an intraperitoneal injection of HBV. Mononuclear cells were isolated from spleen and liver for analysis by flow cytometry...
August 26, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28846458/effects-of-regular-exercise-on-asthma-control-in-young-adults
#19
Sirpa A M Heikkinen, Elina M S Mäkikyrö, Timo T Hugg, Maritta S Jaakkola, Jouni J K Jaakkola
BACKGROUND: According to our systematic literature review, no previous study has assessed potential effects of regular exercise on asthma control among young adults. We hypothesized that regular exercise improves asthma control among young adults. METHODS: We studied 162 subjects with current asthma recruited from a population-based cohort study of 1623 young adults 20-27 years of age. Asthma control was assessed by the occurrence of asthma-related symptoms, including wheezing, shortness of breath, cough, and phlegm production, during the past 12 months...
August 28, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28834781/clinical-management-of-elderly-patients-with-epilepsy-the-use-of-lacosamide-in-a-single-center-setting
#20
Sirpa Rainesalo, Jussi Mäkinen, Jani Raitanen, Jukka Peltola
INTRODUCTION: Lacosamide (LCM) is a third-generation antiepileptic drug (AED) for which there is limited experience in the treatment of elderly patients with epilepsy. This study was performed to evaluate the use of LCM in this particular patient group, focusing on its tolerability and effectiveness. This is a retrospective, single-center study, in patients over 60years old treated with LCM between 1/2010 and 5/2015. Altogether, 233 elderly patients receiving LCM were identified; of these, 67 fulfilled the inclusion criteria, i...
August 20, 2017: Epilepsy & Behavior: E&B
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