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https://www.readbyqxmd.com/read/28715687/highly-selective-and-sensitive-fluorogenic-ferric-probes-based-on-aggregation-enhanced-emission-with-sime3-substituted-polybenzene
#1
Xuefeng Wang, Hua Wang, Qin Jiang, Yong-Ill Lee, Shengyu Feng, Hong-Guo Liu
In this study, thiophene was linked to polybenzene to generate novel fluorescent probes, namely 3,4-diphenyl-2,5-di(2-thienyl)phenyl-trimethylsilane (DPTB-TMS) with a -SiMe3 substituent and 3,4-diphenyl-2,5-di(2-thienyl)phenyl (DPTB) without the -SiMe3 substituent, respectively. Both of the two compounds exhibit aggregation-enhanced emission (AEE) properties in tetrahydrofuran/water mixtures due to restricted intramolecular rotation of the peripheral groups, which make the two compounds good candidates for the detection of Fe(3+) ions in aqueous-based solutions...
July 13, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28712183/association-of-abo-and-rh-blood-group-types-to-hepatitis-b-hepatitis-c-hiv-and-syphilis-infection-a-five-year-experience-in-healthy-blood-donors-in-a-tertiary-care-hospital
#2
Zufishan Batool, Saadia Haroon Durrani, Shazia Tariq
BACKGROUND: Aim of the study: The aim of the study was to find out the frequency of Hepatitis B Hepatitis C, Syphilis, HIV and malaria in apparently healthy blood donors and to find out any association between ABO and Rh blood groups. METHODS: It was a descriptive study carried out at Rehman Medical Institute laboratory. All blood donors who volunteered for blood donation from Jan 2008 to Dec 2014 were reviewed for blood groups and screening tests. Those who were eligible were then screened for Hepatitis B, Hepatitis C, HIV, syphilis and malaria on Architect 8200i through chemiluminescent immunoassay whereas malaria was screened by a thin film...
January 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28712138/hematologic-reference-intervals-and-age-effect-in-european-strigiformes
#3
Susana Agusti Montolio, Rafael Molina López, Carolyn Cray, Santiago Lavín González, Olga Nicolás Francisco, Ignasi Marco Sánchez, Encarna Casas-Díaz, Rafaela Cuenca Valera
BACKGROUND: The clinical importance of hematologic testing in avian veterinary medicine is reflected in the increasing number of studies for the establishment of hematologic RIs of Strigiformes and other species. Age is an important physiologic factor in birds and the effect on hematology variable should be understood. OBJECTIVES: The objective of this study was to determine baseline data of hematologic variables in 5 species of Iberian Strigiformes in different age classes...
July 16, 2017: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/28706555/advances-in-iron-chelation-therapy-transitioning-to-a-new-oral-formulation
#4
Nirmish R Shah
Iron overload is a concern for patients who require repeated red-blood-cell transfusions due to conditions such as sickle cell disease, thalassemia, or myelodysplastic syndromes. The recommended treatment for removing excess iron in these patients is iron chelation therapy. Currently available iron chelators include deferoxamine, which is administered by injection, and deferasirox and deferiprone, both of which are administered orally. Adherence to iron chelator therapy is an important consideration and may be affected by side effects...
2017: Drugs in Context
https://www.readbyqxmd.com/read/28705292/a-case-of-ischemia-induced-perianal-ulceration-mimicking-pyoderma-gangrenosum
#5
Michael Joseph Lavery, Nicola Cooke
A 68-year-old woman, with a 75-pack-year smoking history and a history of chronic excess alcohol intake, presented with a 5-week history of worsening perianal pain and ulceration. She recently had an inpatient admission with back pain and urinary tract infection during which she developed diarrhea and fecal incontinence. Initially, the perianal ulceration was diagnosed as severe irritant contact dermatitis and treated with barrier creams and topical clobetasone 17-butyrate 0.05% weight for weight, oxytetracycline 3...
2017: Skinmed
https://www.readbyqxmd.com/read/28701720/physiological-demands-of-a-swimming-based-video-game-influence-of-gender-swimming-background-and-exergame-experience
#6
Pooya Soltani, Pedro Figueiredo, João Ribeiro, Ricardo J Fernandes, João Paulo Vilas-Boas
Active video games (exergames) may provide short-term increase in energy expenditure. We explored the effects of gender and prior experience on aerobic and anaerobic energy systems contributions, and the activity profiles of 40 participants playing with a swimming exergame. We recorded oxygen consumption and assessed blood lactate after each swimming technique. We also filmed participants' gameplays, divided them into different phases and tagged them as active or inactive. Anaerobic pathway accounted for 8...
July 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28696659/carbon-nanotube-matrix-for-highly-sensitive-biosensors-to-detect-pancreatic-cancer-biomarker-ca19-9
#7
Anshu Thapa, Andrey Coatrini Soares, Juliana Coatrini Soares, Iram Taj Awan, Diogo Volpati, Matias Eliseo Melendez, José Humberto Tavares Guerreiro Fregnani, Andre L Carvalho, Osvaldo Novais Oliveira
Biosensors fabricated with nanomaterials promise faster, cheaper and more efficient alternatives to traditional, often bulky, devices for early cancer diagnosis. In this study, we fabricated a thin film sensing unit on interdigitated gold electrodes combining polyethylenemine and carbon nanotubes in a layer by layer fashion, onto which antibodies anti-CA19-9 were adsorbed with a supporting layer of N-hydroxysuccinimide and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide solution. Using impedance spectroscopy, the pancreatic cancer biomarker CA19-9 was detected in a buffer with limit of detection of 0...
July 11, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28694687/efficacy-and-safety-of-retinol-palmitate-ophthalmic-solution-in-the-treatment-of-dry-eye-a-japanese-phase-ii-clinical-trial
#8
Hiroshi Toshida, Toshinari Funaki, Koichi Ono, Nobuhito Tabuchi, Sota Watanabe, Tamotsu Seki, Hiroshi Otake, Takuji Kato, Nobuyuki Ebihara, Akira Murakami
PURPOSE: The purpose of this study was to investigate the efficacy and safety of the administration of retinol palmitate (VApal) ophthalmic solution (500 IU/mL) for the treatment of patients with dry eye. PATIENTS AND METHODS: This study included 66 patients with dry eye. After a 2-week washout period, patients were randomized (1:1) into either a VApal ophthalmic solution or a placebo group, and a single drop of either solution was administered six times daily for 4 weeks...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28692655/population-based-incidence-seasonality-and-serotype-distribution-of-invasive-salmonellosis-among-children-in-nanoro-rural-burkina-faso
#9
Issa Guiraud, Annelies Post, Seydou Nakanabo Diallo, Palpouguini Lompo, Jessica Maltha, Kamala Thriemer, Christian Marc Tahita, Benedikt Ley, Karim Derra, Emmanuel Bottieau, Adama Kazienga, Céline Schurmans, Raffaella Ravinetto, Eli Rouamba, Johan Van Griensven, Sophie Bertrand, Halidou Tinto, Jan Jacobs
BACKGROUND: Bloodstream infections (BSI) caused by Salmonella Typhi and invasive non-Typhoidal Salmonella (iNTS) frequently affect children living in rural sub-Saharan Africa but data about incidence and serotype distribution are rare. OBJECTIVE: The present study assessed the population-based incidence of Salmonella BSI and severe malaria in a Health and Demographic Surveillance System in a rural area with seasonal malaria transmission in Nanoro, Burkina Faso. METHODS: Children between 2 months-15 years old with severe febrile illness were enrolled during a one-year surveillance period (May 2013-May 2014)...
2017: PloS One
https://www.readbyqxmd.com/read/28691799/solid-contact-ph-sensor-without-co2-interference-with-a-super-hydrophobic-pedot-c14-as-solid-contact-the-ultimate-water-layer-test
#10
Marcin Guzinski, Jennifer Marie Jarvis, Paul D'Orazio, Anahita Izadyar, Bradford D Pendley, Erno Lindner
The aim of this study was to find a conducting polymer-based solid contact (SC) for ion-selective electrodes (ISEs) that could appeal to become the ultimate, generally applicable SC, which in combination with all kinds of ion-selective membranes (ISMs) would match the performance characteristics of conventional ISEs. We present data collected with electrodes utilizing PEDOT-C14, a highly hydrophobic derivative of poly(3,4-ethylenedioxythiophene), PEDOT, as SC and compare its performance characteristics with PEDOT-based SC ISEs...
July 10, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28684135/to-be-blamed-or-pitied-the-effect-of-illness-on-social-behavior-cytokine-levels-and-feed-intake-in-undocked-boars
#11
C Munsterhjelm, J Nordgreen, F Aae, M Heinonen, K Olstad, T Aasmundstad, A M Janczak, A Valros
Tail biting is detrimental to animal welfare and has negative consequences for producer economy. Poor health is one of the risk factors for tail biting. The first aim of this study was therefore to test for links between health status and behavior related to tail biting at the individual level. The second aim of this study was to test whether variation in cytokines was related to variation in social behavior. These small molecules produced upon immune activation are known to influence behavior both in the direction of withdrawal and increased aggression...
July 3, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28683345/interaction-of-acylated-and-unacylated-forms-of-e-coli-alpha-hemolysin-with-lipid-monolayers-a-pm-irras-study
#12
Romina F Vázquez, María A Daza Millone, Felippe J Pavinatto, Vanesa S Herlax, Laura S Bakás, Osvaldo N Oliveira, María E Vela, Sabina M Maté
Uropathogenic strains of Escherichia coli produce virulence factors, such as the protein toxin alpha-hemolysin (HlyA), that enable the bacteria to colonize the host and establish an infection. HlyA is synthetized as a protoxin (ProHlyA) that is transformed into the active form in the bacterial cytosol by the covalent linkage of two fatty-acyl moieties to the polypeptide chain before the secretion of HlyA into the extracellular medium. The aim of this work was to investigate the effect of the fatty acylation of HlyA on protein conformation and protein-membrane interactions...
June 24, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28679107/macrophage-selective-photodynamic-therapy-by-meta-tetra-hydroxyphenyl-chlorin-loaded-polymeric-micelles-a-possible-treatment-for-cardiovascular-diseases
#13
Jos W H Wennink, Yanna Liu, Petri I Mäkinen, Francesca Setaro, Andrès de la Escosura, Meriem Bourajjaj, Jari P Lappalainen, Lari P Holappa, Joep B van den Dikkenberg, Mina Al Fartousi, Panagiotis N Trohopoulos, Seppo Ylä-Herttuala, Tomas Torres, Wim E Hennink, Cornelus F van Nostrum
Selective elimination of macrophages by photodynamic therapy (PDT) is a new and promising therapeutic modality for the reduction of atherosclerotic plaques. m-Tetra(hydroxyphenyl)chlorin (mTHPC, or Temoporfin) may be suitable as photosensitizer for this application, as it is currently used in the clinic for cancer PDT. In the present study, mTHPC was encapsulated in polymeric micelles based on benzyl-poly(ε-caprolactone)-b-methoxy poly(ethylene glycol) (Ben-PCL-mPEG) using a film hydration method, with loading capacity of 17%...
July 2, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28676117/a-5%C3%A2-year-trend-analysis-of-malaria-prevalence-with-in-the-catchment-areas-of-felegehiwot-referral-hospital-bahir-dar-city-northwest-ethiopia-a-retrospective-study
#14
Mulat Yimer, Tadesse Hailu, Wondemagegn Mulu, Bayeh Abera, Workneh Ayalew
BACKGROUND: Malaria is one of the killer diseases in Ethiopia and it is still the first leading cause of death in health facilities. However, there is no information yet regarding the trends of malaria prevalence at health institution and particularly at Felegehiwot referral Hospital. Hence , knowing the trends of malaria prevalence at each health facilities is essential to design appropriate interventions. Therefore, the present study addressed the above gaps. RESULTS: Overall, 14,750 blood films were diagnosed for malaria...
July 4, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28670638/a-comparison-of-rapid-diagnostic-testing-by-plasmodium-lactate-dehydrogenase-and-quantitative-buffy-coat-technique-in-malaria-diagnosis-in-children
#15
Ifeanyi Kanayo Ifeorah, Biobele J Brown, Olugbemiro O Sodeinde
BACKGROUND: The World Health Organization (WHO) considers early and rapid diagnosis as one of the strategies to control malaria. This study compared the performance of Quantitative Buffy Coat (QBC) test and the Plasmodium lactate dehydrogenase (pLDH) rapid diagnostic test (RDT) with microscopy as the gold standard. MATERIALS AND METHODS: The study involved children ages 0-5 years who presented with a history of fever at the University College Hospital, Ibadan, Nigeria...
2017: African Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28667690/sympathetic-and-parasympathetic-cardiac-responses-to-phobia-relevant-and-disgust-specific-emotion-provocation-in-blood-injection-injury-phobia-with-and-without-fainting-history
#16
Erica Simon, Alicia E Meuret, Thomas Ritz
The autonomic regulation in blood-injection-injury (BII) phobia has received particular attention due to the unique link between fear and fainting in this anxiety disorder. However, systematic exploration of sympathetic and parasympathetic cardiac activity during exposure to phobia-relevant emotional stimuli has remained rare and inconclusive, including with regard to disgust, a frequent response to BII stimuli. Existing studies using respiratory sinus arrhythmia (RSA) as a noninvasive index of parasympathetic cardiac activity also have not accounted sufficiently for effects of respiration...
June 30, 2017: Psychophysiology
https://www.readbyqxmd.com/read/28653041/plasmodium-falciparum-genotypes-in-matched-peripheral-placental-and-umbilical-cord-blood-in-an-area-characterised-by-unstable-malaria-transmission-in-eastern-sudan
#17
Omar E Fadlelseed, Maha E Osman, Nahla M Shamseldin, Amar B Elhussein, Ishag Adam
BACKGROUND: There are few published studies on Plasmodium falciparum genotypes in peripheral, placental and umbilical cord blood in areas characterised by unstable malaria transmission. METHOD: A cross-sectional study was conducted to investigate P. falciparum genotypes in matched peripheral, placental and umbilical cord blood in eastern Sudan. Thick blood smears and P. falciparum merozoite surface protein 1 (MSP1) and 2 (MSP2) genes as polymorphic markers in polymerase chain reactions were investigated in 3 kinds of samples of 153 pregnant women at delivery...
June 2017: Heliyon
https://www.readbyqxmd.com/read/28650215/tolerability-of-topical-tocilizumab-eyedrops-in-dogs-a-pilot-study
#18
Vatinee Y Bunya, Simone Iwabe, Ilaria Macchi, Mina Massaro-Giordano, Maxwell Pistilli, Gustavo D Aguirre
PURPOSE: The aim of this study was to examine the tolerability of topical tocilizumab eyedrops in normal dogs and to assess whether this preparation alters tear film cytokine levels or conjunctival cytokine mRNA expression. METHODS: Two percent tocilizumab eyedrops were administered to the right eyes and artificial tears to the left eyes of 10 dogs with no anterior segment pathology 3 times daily for 4 weeks. Portable slit-lamp examinations and Schirmer tear testing were performed at baseline and day 1 week 4, as well as 2 weeks after treatment (week 6)...
June 26, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28644307/x-linked-sideroblastic-anemia-in-a-malay-boy-with-alas2-s568g-mutation
#19
Thomas A K Susanto, Rajat Bhattacharyya
Dimorphism in peripheral blood film was noted in a 16 year old Malay boy with anemia who was eventually diagnosed with X-linked sideroblastic anemia. A mutation in ALAS2 S568G was identified which has not been described previously in a Malay ethnic group.
July 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28629077/effects-of-the-surface-modification-of-polyurethane-substrates-on-genotoxicity-and-blood-activation-processes
#20
Roman Major, Hanna Plutecka, Anna Gruszczynska, Juergen M Lackner, Boguslaw Major
The aim of this study was to determine the mutagenic and thrombogenic potential of a material composed of a thin coating deposited on a polymeric substrate. In this work, a surface was modified in a manner that would mimic the function of cellular niches. Finally, the surfaces should actively capture and differentiate progenitor cells from the blood stream. Thin films with 10 to 500nm thicknesses were deposited by unbalanced, pulsed DC magnetron sputtering on smooth polyurethane. Such high energy conditions led to a stiffening of the polymer surface layers by pseudodiffusion during the initial stages of film growth...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
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