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https://www.readbyqxmd.com/read/28336583/bruising-and-abnormal-leucocytes-on-a-blood-film-a-haematological-emergency
#1
Selina J Chavda, Sophie Lindsay, Fenella Willis, Mickey Koh
No abstract text is available yet for this article.
March 23, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28335694/construction-of-three-dimensional-dermo-epidermal-skin-equivalents-using-cell-coating-technology-and-their-utilization-as-alternative-skin-for-permeation-studies-and-skin-irritation-tests
#2
Takami Akagi, Mayuka Nagura, Ayami Hiura, Hajime Kojima, Mitsuru Akashi
In vitro generated human skin equivalents are generating interest as promising tools in basic research, as alternatives to animal testing and for clinical applications in regenerative medicine. For prediction of skin irritation and corrosion, three-dimensional (3D) human skin equivalents consisting of differentiated human keratinocytes have been developed and some models have been internationally accepted. However, more delicate assessments using full-thickness skin models, such as skin sensitization tests cannot be performed because of the lack of a dermis containing fibroblasts or appendages...
March 23, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28330377/enhanced-oral-bioavailability-and-sustained-delivery-of-glimepiride-via-niosomal-encapsulation-in-vitro-characterization-and-in-vivo-evaluation
#3
Amira Mohamed Mohsen, Mona Mahmoud AbouSamra, Shaimaa Ahmed ElShebiney
This study was designed to investigate the potency of niosomes, for glimepiride (GLM) encapsulation, aiming at enhancing its oral bioavailability and hypoglycemic efficacy. Niosomes containing non-ionic surfactants (NIS) were prepared by thin film hydration technique and characterized. In-vitro release study was performed using a dialysis technique. In-vivo pharmacodynamic studies, as well as pharmacokinetic evaluation were performed on alloxan induced diabetic rats. GLM niosomes exhibited high entrapment efficiency percentages (E...
March 23, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28328296/the-relationship-between-metabolic-syndrome-its-components-and-dry-eye-a-cross-sectional-study
#4
Sevil Karaman Erdur, Rukiye Aydin, Mustafa Ozsutcu, Oktay Olmuscelik, Mustafa Eliacik, Goktug Demirci, Mehmet Selim Kocabora
PURPOSE: The aim of this study was to evaluate tear osmolarity and tear film function and ocular surface changes in patients with metabolic syndrome. METHODS: 108 eyes of 64 patients with metabolic syndrome (group 1) and 110 eyes of 55 healthy individuals (group 2) were included in this cross-sectional study. All participants were evaluated using the Ocular Surface Disease Index (OSDI) questionnaire, Schirmer I test, tear film break-up time (TBUT), and tear osmolarity...
March 22, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28327452/sensitive-detection-of-l-5-hydroxytryptophan-based-on-molecularly-imprinted-polymers-with-graphene-amplification
#5
Lu Chen, Hui-Ting Lian, Xiang-Ying Sun, Bin Liu
A novel electrochemical sensor was presented for the determination of L-5-hydroxytryptophan (L-5-HTP) based on a graphene-chitosan molecularly imprinted film modified on the surface of glassy carbon electrode (GR-MIP/GCE). The morphology and composition of the imprinted film were observed in field emission scanning electron microscopy (FESEM), raman spectroscopy and fourier transform infrared (FTIR). The properties of the sensor were evaluated by electrochemical techniques. Under the optimal conditions, the peak currents of L-5-HIP were found to be linear in the concentration range of 0...
March 19, 2017: Analytical Biochemistry
https://www.readbyqxmd.com/read/28323491/the-effect-of-closed-eye-tear-film-conditions-on-blood-isolated-neutrophils-in-vitro
#6
Cameron Postnikoff, Maud Gorbet
PURPOSE: Eyelid closure results in influx of neutrophils onto the ocular surface, which are non-responsive to inflammatory stimuli. This investigation examined whether incubation of blood-isolated neutrophils in closed-eye conditions induce a tear-film neutrophil phenotype. METHODS: Blood-isolated neutrophils were incubated combining various conditions: hypoxia, corneal epithelial cells (HCEC), artificial tear solution (ATS). RESULTS: A hypoxic environment induced no differential effect on membrane receptor expression...
March 21, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28320389/age-and-geographic-patterns-of-plasmodium-falciparum-malaria-infection-in-a-representative-sample-of-children-living-in-burkitt-lymphoma-endemic-areas-of-northern-uganda
#7
Marlena Maziarz, Tobias Kinyera, Isaac Otim, Paul Kagwa, Hadijah Nabalende, Ismail D Legason, Martin D Ogwang, Samuel Kirimunda, Benjamin Emmanuel, Steven J Reynolds, Patrick Kerchan, Moses M Joloba, Andrew W Bergen, Kishor Bhatia, Ambrose O Talisuna, Robert J Biggar, James J Goedert, Ruth M Pfeiffer, Sam M Mbulaiteye
BACKGROUND: Falciparum malaria is an important risk factor for African Burkitt lymphoma (BL), but few studies have evaluated malaria patterns in healthy BL-age children in populations where both diseases are endemic. To obtain accurate current data, patterns of asymptomatic malaria were investigated in northern Uganda, where BL is endemic. METHODS: Between 2011 and 2015, 1150 apparently healthy children under 15 years old were sampled from 100 villages in northern Uganda using a stratified, multi-stage, cluster survey design...
March 20, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28316450/a-case-of-anemia-how-important-is-peripheral-blood-film-before-transfusing
#8
Pankaj Kumar, Geetanjali Jindal, Vishal Guglani
No abstract text is available yet for this article.
January 2017: Asian Journal of Transfusion Science
https://www.readbyqxmd.com/read/28306134/further-evidence-of-a-prolonged-hypotensive-and-a-bradycardic-effect-after-mandibular-extension-in-normal-volunteers
#9
C Del Seppia, S Ghione, Paola Foresi, E Fommei, D Lapi, A Colantuoni, R Scuri
We previously reported that in normotensive humans submaximal mouth opening (mandibular extension) obtained by an ad hoc dilator (spring device), associated with partial masticatory movements and prolonged for 10 minutes is followed by a long-lasting reduction of blood pressure (BP) and heart rate (HR). Similar results were obtained by us in anesthetized rats. A recent independent study failed to confirm the results in the normotensive human. We reassessed, in 25 normotensive volunteers, the effects on BP and HR of mandibular extension obtained by the spring device associated with partial masticatory movements compared to a control procedure, consisting in keeping a tongue depressor between the incisor teeth...
December 1, 2016: Archives Italiennes de Biologie
https://www.readbyqxmd.com/read/28302147/soil-transmitted-helminths-and-plasmodium-falciparum-malaria-among-individuals-living-in-different-agroecosystems-in-two-rural-communities-in-the-mount-cameroon-area-a-cross-sectional-study
#10
Irene Ule Ngole Sumbele, Gladys Belanka Nkemnji, Helen Kuokuo Kimbi
BACKGROUND: Soil-transmitted helminths (STHs) and Plasmodium falciparum infections remain public health problems in Cameroon. A cross-sectional study was carried out in the Mount Cameroon area to determine the prevalence and intensity of STHs and P. falciparum infections in individuals living in different agroecosystems; to assess the influence of these infections on haematological parameters; and to identify the risk factors associated with STH infections. METHODS: STH and malaria parasites were detected using the Kato-Katz method and Giemsa staining of blood films, respectively...
March 16, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28293445/microscopic-and-molecular-detection-of-camel-piroplasmosis-in-gadarif-state-sudan
#11
Abdalla Mohamed Ibrahim, Ahmed A H Kadle, Hamisi Said Nyingilili
The socioeconomic importance of camels (Camelus dromedarius) could not be neglected in the Sudan. The present study was planned to confirm the presence of piroplasmosis in camels from the Eastern region of the Sudan (Gedarif State) using microscopical (blood film) and molecular technique (PCR). A total of 55 camels of different sexes (34 females and 21 males) were sampled from four localities of the state between January 2011 and January 2012. The prevalence rates using parasitological and molecular examinations were 43...
2017: Veterinary Medicine International
https://www.readbyqxmd.com/read/28287511/magnetic-levitation-coupled-with-portable-imaging-and-analysis-for-disease-diagnostics
#12
Stephanie M Knowlton, Bekir Yenilmez, Reza Amin, Savas Tasoglu
Currently, many clinical diagnostic procedures are complex, costly, inefficient, and inaccessible to a large population in the world. The requirements for specialized equipment and trained personnel require that many diagnostic tests be performed at remote, centralized clinical laboratories. Magnetic levitation is a simple yet powerful technique and can be applied to levitate cells, which are suspended in a paramagnetic solution and placed in a magnetic field, at a position determined by equilibrium between a magnetic force and a buoyancy force...
February 19, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28277010/in-vitro-and-in-vivo-evaluation-of-the-chitosan-tur-composite-film-for-wound-healing-applications
#13
Qin Zou, Bin Cai, Junfeng Li, Jidong Li, Yubao Li
We have developed tourmaline/chitosan (Tur/CS) composite films for wound healing applications. The characteristics of composite films were studied by optical microscope, infrared spectra and X-ray diffraction. Tur particles were uniformly distributed in the CS film and the crystal structure of CS was not remarkably changed except the decrease of crystallinity. The influence of Tur on wound healing applications was characterized by modulating Tur concentrations in the Tur/CS composite film prepared by loading Tur powder into CS matrix with different proportion (0, 1/40 and 1/10)...
May 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28268325/a-study-for-the-development-of-k-sound-based-automatic-blood-pressure-device-using-pvdf-film
#14
Xiong Li, Gayathri V Panicker, Jae J Im
Traditional indirect standard measurement of blood pressure is based on hearing Korotkoff sounds to determine systolic and diastolic blood pressure. However, the problem exists among different types of automatic blood pressure monitoring devices because of no standard algorithm for estimating accurate blood pressure values. Aim of the study was to develop an automatic blood pressure measurement device based on Korotkoff sounds. PVDF(poliyvinylidene fluoride) film was used as a contact microphone to detect Korotkoff sounds on the brachial artery, and pressure sensor was used to obtain cuff pressure...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28265257/regulatory-b-cells-in-seropositive-myasthenia-gravis-versus-healthy-controls
#15
Md Rezaul Karim, Hong-Yan Zhang, Jiang Yuan, Qiang Sun, Yun-Fu Wang
OBJECTIVE: To find out if the failure in immunotolerance of myasthenia gravis (MG) is a possible aspect of deduction in Breg cells and to characterize B cell subsets in MG. METHODS: Flow cytometry detection and enzyme-linked immunosorbent assays in peripheral blood films of 10 MG patients and 10 healthy controls (HCs) were performed after isolation of B cells. The CD19(+)CD5(+)CD1d(+) Breg cells percentages were measured to complement a B cell phenotype assay and frequencies of B cell subsets...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28257059/chitosan-based-multifunctional-platforms-for-local-delivery-of-therapeutics
#16
REVIEW
Seong-Chul Hong, Seung-Yup Yoo, Hyeongmin Kim, Jaehwi Lee
Chitosan has been widely used as a key biomaterial for the development of drug delivery systems intended to be administered via oral and parenteral routes. In particular, chitosan-based microparticles are the most frequently employed delivery system, along with specialized systems such as hydrogels, nanoparticles and thin films. Based on the progress made in chitosan-based drug delivery systems, the usefulness of chitosan has further expanded to anti-cancer chemoembolization, tissue engineering, and stem cell research...
March 1, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28254325/vacuum-arc-plasma-deposition-of-thin-titanium-dioxide-films-on-silicone-elastomer-as-a-functional-coating-for-medical-applications
#17
Cécile Boudot, Marvin Kühn, Marina Kühn-Kauffeldt, Jochen Schein
Silicone elastomer is a promising material for medical applications and is widely used for implants with blood and tissue contact. However, its strong hydrophobicity limits adhesion of tissue cells to silicone surfaces, which can impair the healing process. To improve the biological properties of silicone, a triggerless pulsed vacuum cathodic arc plasma deposition technique was applied to deposit titanium dioxide (TiO2) films onto the surface. Scanning electron microscopy, atomic force microscopy, X-ray photoelectron spectroscopy, Raman spectroscopy and contact angle measurements were used for coating characterization...
May 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28230203/water-insoluble-photosensitizer-nanocolloids-stabilized-by-supramolecular-interfacial-assembly-towards-photodynamic-therapy
#18
Yamei Liu, Kai Ma, Tifeng Jiao, Ruirui Xing, Guizhi Shen, Xuehai Yan
Nanoengineering of hydrophobic photosensitizers (PSs) is a promising approach for improved tumor delivery and enhanced photodynamic therapy (PDT) efficiency. A variety of delivery carriers have been developed for tumor delivery of PSs through the enhanced permeation and retention (EPR) effect. However, a high-performance PS delivery system with minimum use of carrier materials with excellent biocompatibility is highly appreciated. In this work, we utilized the spatiotemporal interfacial adhesion and assembly of supramolecular coordination to achieve the nanoengineering of water-insoluble photosensitizer Chlorin e6 (Ce6)...
February 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28226486/a-study-for-the-development-of-k-sound-based-automatic-blood-pressure-device-using-pvdf-film
#19
Xiong Li, Gayathri V Panicker, Jae J Im, Xiong Li, Gayathri V Panicker, Jae J Im, Gayathri V Panicker, Xiong Li, Jae J Im
Traditional indirect standard measurement of blood pressure is based on hearing Korotkoff sounds to determine systolic and diastolic blood pressure. However, the problem exists among different types of automatic blood pressure monitoring devices because of no standard algorithm for estimating accurate blood pressure values. Aim of the study was to develop an automatic blood pressure measurement device based on Korotkoff sounds. PVDF(poliyvinylidene fluoride) film was used as a contact microphone to detect Korotkoff sounds on the brachial artery, and pressure sensor was used to obtain cuff pressure...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28215086/salt-segregation-and-sample-cleanup-on-perfluoro-coated-nanostructured-surfaces-for-laser-desorption-ionization-mass-spectrometry-of-biofluid-samples
#20
Ya Zhou, Chen Peng, Kenneth D Harris, Rupasri Mandal, D Jed Harrison
We present a surface assisted laser desorption ionization (SALDI) technique, coupled with fluorocarbon coating, to achieve selective segregation of ionic and/or hydrophilic analytes from background biofluid electrolytes for quantiatve mass spectrometric analysis. By controlling the contact angle of (1H,1H,2H,2H-perfluorooctyl) trichlorosilane or (1H,1H,2H,2H-perfluorooctyl) dimethylchlorosilane to a specific range (105-120°), background electrolytes can be made to segregate from hydrophilic analytes during a drying step on the surface of a highly nanoporous thin film...
March 21, 2017: Analytical Chemistry
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