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Blood film

Fengyu Yang, Yonglan Liu, Yanxian Zhang, Baiping Ren, Jianxiong Xu, Jie Zheng
Rational design of biomaterials with antifouling properties still remains a challenge, but is important for many bench-to-bedside applications for biomedical implants, drug delivery carriers, and marine coatings. Herein we synthesized and characterized poly(N-acryloylglycinamide) (polyNAGA) and then grafted poly(NAGA) onto Au substrate to form polymer brushes with well controlled film stability, wettability and thickness using the surface-initiated atom transfer radical polymerization (SI-ATRP). The NAGA monomer integrates two hydrophilic amides on the side chain to enhance surface hydration, which is thought as a critical contributor to antifouling property...
November 21, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
Carmen Rojas-Martínez, Roger Iván Rodríguez-Vivas, Julio Vicente Figueroa Millán, Carlos Ramón Bautista-Garfias, Roberto Omar Castañeda-Arriola, José Juan Lira-Amaya, Patricia Vargas Urióstegui, Juan José Ojeda Carrasco, Jesús Antonio Álvarez Martínez
An attenuated live vaccine containing Babesia bovis and B. bigemina cultured in vitro with a serum-free medium was assessed for its clinical protection conferred of naïve cattle, under natural tick-challenge in a high endemicity zone to Babesia spp. Three groups of six animals were treated as follows: group I (GI) received a vaccine derived from parasites cultured with a free-serum medium; group II (GII) were immunized with the standard vaccine, with parasites cultured in a medium supplemented with 40% (v/v) bovine serum; and a control group (GIII) inoculated with non-infected bovine erythrocytes...
November 16, 2017: Parasitology International
Zhenkun Han, Suwen Jiang, Baoqin Fu, Min Zhao
OBJECTIVE: To prepare paraoxonase 1 (PON1) liposomes, and investigate pharmacokinetics of common PON1 liposomes (L-PON1) and polyethylene glycol-modified PON1 long circulating liposomes (PEG-PON1-LCL) in rats after intravenous administration. METHODS: L-PON1 and PEG-PON1-LCL were prepared by film dispersion method. The entrapment efficiency, mean diameter and Zeta potential of the liposomes were measured, and the stability was evaluated. Thirty-six Wistar rats were divided into three groups according to random number table, with 12 rats in each group...
November 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Diego Villa Clé
No abstract text is available yet for this article.
October 2017: Revista Brasileira de Hematologia e Hemoterapia
Wajid Hafeez, S Rajalakshmi, S Sripriya, M Madhu Bashini
Background and Aim Diagnosis of typhoid is challenging when blood cultures fail to isolate Salmonella species. We report our experience with interpreting computed tomography (CT) abdomen findings in a case series of typhoid fever. Methods The case series consisted of patients who had a CT abdomen done as part of their investigations and a final diagnosis of typhoid fever. The CT films were reviewed and findings evaluated for distinctive features. Results During 2011-2017, 11 patients met the inclusion criteria...
January 1, 2017: Tropical Doctor
K Fixter, D J Rabbolini, B Valecha, M-C Morel-Kopp, S Gabrielli, Q Chen, W S Stevenson, C M Ward
INTRODUCTION: Mean platelet volume (MPV) assists the differential diagnosis of inherited thrombocytopenia (IT) but lacks standardisation and varies between automated analysers. Classification of IT based on mean platelet diameter (MPD) has been proposed by an international collaborative study but has not been validated. METHODS: To assess the applicability of MPD to classify forms of IT, digital images of blood films from patients with established genetic causes for IT were generated, and the MPD measured (ZEISS Axio-scanner and Image J software) by a blinded reviewer...
November 16, 2017: International Journal of Laboratory Hematology
Audrey Gossart, Kyle G Battiston, Adeline Gand, Emmanuel Pauthe, J Paul Santerre
Monocyte interactions with materials that are biofunctionalized with fibronectin (Fn) are of interest because of the documented literature which associates this protein with white blood cell function at implant sites. A degradable-polar hydrophobic ionic polyurethane (D-PHI), has been reported to promote an anti-inflammatory response from human monocytes. The aim of the current work was to study the influence of intrinsic D-PHI material chemistry on Fn adsorption (mono and multi-layer structures), and to investigate the influence of such chemistry on the structural state of the Fn, as well as the latter's influence on the activity of human monocytes on the protein coated substrates...
November 7, 2017: Acta Biomaterialia
Jennifer L Burnett, Jennifer L Carns, Rebecca Richards-Kortum
BACKGROUND: Optical detection of circulating haemozoin has been suggested as a needle free method to diagnose malaria using in vivo microscopy. Haemozoin is generated within infected red blood cells by the malaria parasite, serving as a highly specific, endogenous biomarker of malaria. However, phagocytosis of haemozoin by white blood cells which persist after the infection is resolved presents the potential for false positive diagnosis; therefore, the focus of this work is to identify a feature of the haemozoin signal to discriminate between infected red blood cells and haemozoin-containing white blood cells...
November 7, 2017: Malaria Journal
Wael M Darwish, Noha A Bayoumi, Mohamed T El-Kolaly
Nitazoxanide [2-(Acetyloxy)-N-(5-nitro-2-thiazolyl)benzamide], usually referred as NTZ, is an antiparasites drug with a potential anti-cancer reactivity. However, the bioavailability of nitazoxanide is limited due to its poor water solubility. In this study, nitazoxanide could be successfully incorporated in a stable biocompatible liposome (NTZ-LP) using a modified thin film hydration technique. Further, a novel lipophilic phthalocyanine star polymer R4PcZn was prepared as photosensitizer and in situ incorporated with NTZ in the liposome formulation affording a laser-responsive liposome (NTZ-ZnPc-LP)...
October 31, 2017: European Journal of Pharmaceutical Sciences
David J Rabbolini, Yenna Chun, Maya Latimer, Shinji Kunishima, Kathleen Fixter, Bhavia Valecha, Peter Tan, Lee Ping Chew, Benjamin T Kile, Rachel Burt, Kottayam Radhakrishnan, Robert Bird, Paul Ockelford, Sara Gabrielli, Qiang Chen, William S Stevenson, Christopher M Ward, Marie-Christine Morel-Kopp
MYH9-related disorders (MYH9-RDs) caused by mutation of the MYH9 gene which encodes non-muscle myosin heavy-chain-IIA (NMMHC-IIA), an important motor protein in hemopoietic cells, are the most commonly encountered cause of inherited macrothrombocytopenia. Despite distinguishing features including an autosomal dominant mode of inheritance, giant platelets on the peripheral blood film accompanied by leucocytes with cytoplasmic inclusion bodies (döhle-like bodies), these disorders remain generally under-recognized and often misdiagnosed as immune thrombocytopenia (ITP)...
November 1, 2017: Platelets
Deepak Kumar Khajuria, Saadath Fathima Zahra, Rema Razdan
The aim of this study was to develop a chitosan-based risedronate/zinc-hydroxyapatite intrapocket dental film (CRZHDF) for applications in the treatment of alveolar bone loss in an animal model of periodontitis. The physical characteristics (folding endurance, pH, mucoadhesive strength, risedronate content and release) of CRZHDF, exhibited results within the limit. X-ray diffraction analysis indicates reduced or disappeared crystallinity of risedronate and zinc-hydroxyapatite in presence of chitosan. Further, FTIR studies revealed stability of CRZHDF and compatibility between risedronate, zinc-hydroxyapatite and chitosan...
October 31, 2017: Journal of Biomaterials Science. Polymer Edition
Kenji O Mfuh, Samuel Tassi Yunga, Livo F Esemu, Obase Ngemani Bekindaka, Jessica Yonga, Jean Claude Djontu, Calixt D Mbakop, Diane W Taylor, Vivek R Nerurkar, Rose G F Leke
BACKGROUND: Current malaria diagnostic methods require blood collection, that may be associated with pain and the risk of transmitting blood-borne pathogens, and often create poor compliance when repeated sampling is needed. On the other hand, the collection of saliva is minimally invasive; but saliva has not been widely used for the diagnosis of malaria. The aim of this study was to evaluate the diagnostic performance of saliva collected and stored at room temperature using the OMNIgene(®)•ORAL kit for diagnosing Plasmodium falciparum malaria...
October 27, 2017: Malaria Journal
Tsontcho Ianchulev, Robert Weinreb, James C Tsai, Shan Lin, Louis R Pasquale
AIM: Conventional eyedropper-delivered volumes (25-50 µl) exceed the eye's usual tear-film volume (7 µl) and precorneal reservoir capacity, risking overflow and ocular/systemic complications. Piezoelectric high-precision microdosing may circumvent these limitations. Results & methodology: In this masked, nonrandomized, cross-over study, subjects (n = 12) underwent pupil dilation with topical phenylephrine (PE) administered by 32-µl eyedropper (2.5% or 10% formulation) and 8-µl electronic microdosing (10% formulation)...
October 27, 2017: Therapeutic Delivery
Parul D Shah, Tanmay K Mehta
CONTEXT: Despite a wide overlap between endemic areas for two important vector-borne infections, malaria and dengue, published reports of co-infections are scarce till date. AIMS: To find the incidence of dengue and malaria co-infection as well as to ascertain the severity of such dengue and malaria co-infection based on clinical and haematological parameters. SETTING AND DESIGN: Observational, retrospective cross-sectional study was designed including patients who consulted the tertiary care hospital of Ahmedabad seeking treatment for fever compatible with malaria and/or dengue...
July 2017: Indian Journal of Medical Microbiology
Ahmed Rasheed, Emad Iranmanesh, Weiwei Li, Hai Ou, Andrey S Andrenko, Kai Wang
Autonomous wearable biomedical sensors enable continuous human body vital signs monitoring with features such as being conformable, mobile, cost-effective and self-powered. In this work, we report on an autonomous and multi-positional sensor capable of heart rate and blood pressure monitoring. The device concept is based on a piezoelectric-charge-gated thin-film transistor (PCGTFT) where a polyvinylidene fluoride (PVDF) piezoelectric sandwich structure is incorporated with an amorphous silicon (a-Si:H) dual-gate TFT (DGTFT)...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
John P McQuilling, Sivanandane Sittadjody, Samuel Pendergraft, Alan C Farney, Emmanuel C Opara
Type-1 Diabetes (T1D) is a devastating autoimmune disorder which results in the destruction of beta cells within the pancreas. A promising treatment strategy for T1D is the replacement of the lost beta cell mass through implantation of immune-isolated microencapsulated islets referred to as the bioartificial pancreas. The goal of this approach is to restore blood glucose regulation and prevent the long-term comorbidities of T1D without the need for immunosuppressants. A major requirement in the quest to achieve this goal is to address the oxygen needs of islet cells...
October 20, 2017: Biomaterials Science
Omar Vázquez-Estrada, Augusto García-Valenzuela
The main objective of this paper is to endorse a recently derived theoretical model for the coherent reflectance and transmittance from a surface supporting a disordered monolayer of large and tenuous particles by comparison with experimental measurements. The model is based on the so-called anomalous-diffraction approximation and is assumed to be valid for small and moderate angles of incidence. We prepared disordered monolayers of spherical polystyrene particles of 1.8 μm diameter and of human red blood cells on glass microscope slides...
September 1, 2017: Applied Optics
Angela Siner, Sze-Tze Liew, Khamisah Abdul Kadir, Dayang Shuaisah Awang Mohamad, Felicia Kavita Thomas, Mohammad Zulkarnaen, Balbir Singh
BACKGROUND: Plasmodium knowlesi, a simian malaria parasite, has become the main cause of malaria in Sarawak, Malaysian Borneo. Epidemiological data on malaria for Sarawak has been derived solely from hospitalized patients, and more accurate epidemiological data on malaria is necessary. Therefore, a longitudinal study of communities affected by knowlesi malaria was undertaken. METHODS: A total of 3002 blood samples on filter paper were collected from 555 inhabitants of 8 longhouses with recently reported knowlesi malaria cases in the Betong Division of Sarawak, Malaysian Borneo...
October 17, 2017: Malaria Journal
Mahsa Hakani, Vahid Haddadi-Asl, Seyed Shahrooz Zargarian, Mohamad Hossein Moghadasi
In order to improve surface hydrophilicity, blood compatibility and cell-anti adhesion of Polypropylene (PP) film, PPO-PEO-PPO used as macromolecular surface modifier through physical blending. Surface properties of blended PP/PF127 samples were investigated by attenuated total reflection infrared spectroscopy (ATR-FTIR) and water contact angle (WCA) measurements. Results demonstrated that pluronic F127 migrated to the surface. Thus, mechanical properties of blended PP/PF127 samples with the aim of the revealing the effects of the presence of modifier in the bulk were investigated through Differential Scanning Calorimetry (DSC), X-ray diffraction (XRD) and tensile tests...
October 13, 2017: Journal of Biomedical Materials Research. Part A
Na Huang, Ming He, Haosheng Shi, Yuan Zhao, Man Lu, Xianbing Zou, Lei Yao, Huabei Jiang, Lei Xi
OBJECTIVE: In this study, we present the design, fabrication, and evaluation of a curved-array-based photoacoustic imaging system designed for imaging vasculatures inside human finger joints with multispectral strategy. METHODS: The transducers was fabricated with polyvinylidene fluoride (PVDF) film with a size of 30 mm×2.8 mm, and a curvature radius of 82 mm. A detailed comparison between the PVDF transducer and commercial piezoelectric ceramic (PTZ) transducers was performed...
October 2, 2017: IEEE Transactions on Bio-medical Engineering
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