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https://www.readbyqxmd.com/read/29790655/maximising-yield-of-peripheral-blood-flow-cytometry-for-chronic-lymphoproliferative-disorders
#1
H Y Lim, F S Hong
INTRODUCTION: Flow cytometry is used in the diagnosis of haematological diseases including chronic lymphoproliferative disorders. This audit aims to ascertain the real-world indications for peripheral blood (PB) flow cytometry and which of these are associated with higher diagnostic yields. METHODS: All PB flow cytometry requests for chronic lymphoproliferative disorders from 1 January 2014 to 31 December 2014 were identified using the laboratory information system...
May 23, 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29788723/biomineralization-of-osteoblasts-on-dlc-coated-surfaces-for-bone-implants
#2
Subramanian B, Thanka Rajan S, P J Martin, Vijay Vaithilingam, Penelope A Bean, Margaret D M Evans, A Bendavid
Diamond like carbon (DLC) films were deposited onto Ti6Al4V and Si wafer substrates by RF plasma enhanced chemical vapor deposition. The influence of dopants such as fluorine (F), silicon (Si), and nitrogen (N) on composition, structure, and biocompatibility was investigated. Ion scattering spectroscopy analysis revealed the presence of dopant atoms in the outer-most layers of the films. Raman studies showed that the position of the G-band shifts to higher frequencies with the fluorine and nitrogen content in the DLC film, whereas the incorporation of Si into DLC induces a decrease of the position of the G peak...
May 22, 2018: Biointerphases
https://www.readbyqxmd.com/read/29779491/trypanosoma-brucei-rhodesiense-infection-in-a-chinese-traveler-returning-from-the-serengeti-national-park-in-tanzania
#3
Qin Liu, Xiao-Ling Chen, Mu-Xin Chen, Han-Guo Xie, Qing Liu, Zhu-Yun Chen, Yao-Ying Lin, Hua Zheng, Jia-Xu Chen, Yi Zhang, Xiao-Nong Zhou
BACKGROUND: Human African trypanosomiasis (HAT) is one of the most complex parasitic diseases known to humankind. It usually occurs in endemic areas in Africa, but is occasionally detected in returning travelers and migrants in non-endemic countries. CASE PRESENTATION: In August 2017, a case of HAT was diagnosed in China in a traveler returning from the Masai Mara area in Kenya and the Serengeti area in Tanzania. The traveler visited Africa from 23 July to 5 August, 2017...
May 21, 2018: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/29763668/evaluation-of-automated-loop-mediated-amplification-lamp-for-routine-malaria-detection-in-blood-samples-of-german-travelers-a-cross-sectional-study
#4
Hagen Frickmann, Rebecca Hinz, Sandra Rojak, Insa Bonow, Stefanie Ruben, Christine Wegner, Iris Zielke, Ralf Matthias Hagen, Egbert Tannich
BACKGROUND: We assessed a commercial loop-mediated amplification (LAMP) platform for its reliability as a screening tool for malaria parasite detection. METHODS: A total of 1000 blood samples from patients with suspected or confirmed malaria submitted to the German National Reference Center for Tropical Pathogens were subjected to LAMP using the Meridian illumigene Malaria platform. Results were compared with microscopy from thick and thin blood films in all cases...
May 12, 2018: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/29747621/prevalence-and-clinical-characteristics-of-dry-eye-disease-in-community-based-type-2-diabetic-patients-the-beixinjing-eye-study
#5
Xinrong Zou, Lina Lu, Yi Xu, Jianfeng Zhu, Jiangnan He, Bo Zhang, Haidong Zou
BACKGROUND: This study was performed to evaluate the prevalence and clinical characteristics of dry eye disease (DED) in community-based type 2 diabetic patients and to identify the associated factors related with DED. METHODS: A total of 1360 type 2 diabetic patients in the Beixinjing community were randomly selected. All participants were given a questionnaire that assessed basic information and subjective symptoms.DED was diagnosed using the revised Japanese DED diagnostic criteria...
May 10, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29725736/conventional-plate-fixation-method-versus-pre-operative-virtual-simulation-and-three-dimensional-printing-assisted-contoured-plate-fixation-method-in-the-treatment-of-anterior-pelvic-ring-fracture
#6
Chun-Chi Hung, Yuan-Ta Li, Yu-Ching Chou, Jia-En Chen, Chia-Chun Wu, Hsain-Chung Shen, Tsu-Te Yeh
PURPOSE: Treating pelvic fractures remains a challenging task for orthopaedic surgeons. We aimed to evaluate the feasibility, accuracy, and effectiveness of three-dimensional (3D) printing technology and computer-assisted virtual surgery for pre-operative planning in anterior ring fractures of the pelvis. We hypothesized that using 3D printing models would reduce operation time and significantly improve the surgical outcomes of pelvic fracture repair. METHODS: We retrospectively reviewed the records of 30 patients with pelvic fractures treated by anterior pelvic fixation with locking plates (14 patients, conventional locking plate fixation; 16 patients, pre-operative virtual simulation with 3D, printing-assisted, pre-contoured, locking plate fixation)...
May 3, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29723339/comparing-osteogenic-effects-between-concentrated-growth-factors-and-the-acellular-dermal-matrix
#7
RANDOMIZED CONTROLLED TRIAL
Luo Huang, Rui Zou, Jinquan He, Kexiong Ouyang, Zhengguo Piao
Concentrated growth factor (CGF) is an autogenuous product that contains highly concentrated number of platelets and can be derived from venous blood by selective centrifugation. It has been speculated that local growth factors in human platelets (insulinlike growth factor, IGF; transforming growth factor, TGF-b; platelet derived growth factor, PDGF) would enhance healing of grafts and also counteract resorption. The osteogensis effect of CGF and acellular dermal matrix (ADM) for alveolar cleft defects was evaluated in this study...
2018: Brazilian Oral Research
https://www.readbyqxmd.com/read/29723168/malaria-surveillance-united-states-2015
#8
Kimberly E Mace, Paul M Arguin, Kathrine R Tan
PROBLEM/CONDITION: Malaria in humans is caused by intraerythrocytic protozoa of the genus Plasmodium. These parasites are transmitted by the bite of an infective female Anopheles species mosquito. The majority of malaria infections in the United States occur among persons who have traveled to regions with ongoing malaria transmission. However, malaria is occasionally acquired by persons who have not traveled out of the country through exposure to infected blood products, congenital transmission, laboratory exposure, or local mosquitoborne transmission...
May 4, 2018: MMWR. Surveillance Summaries: Morbidity and Mortality Weekly Report. Surveillance Summaries
https://www.readbyqxmd.com/read/29723163/a-fibrin-biofilm-covers-the-blood-clot-and-protects-from-microbial-invasion
#9
Fraser L Macrae, Cédric Duval, Praveen Papareddy, Stephen R Baker, Nadira Yuldasheva, Katherine J Kearney, Helen R McPherson, Nathan Asquith, Joke Konings, Alessandro Casini, Jay L Degen, Simon D Connell, Helen Philippou, Alisa S Wolberg, Heiko Herwald, Robert As Ariëns
Haemostasis requires conversion of fibrinogen to fibrin fibres that generate a characteristic network, interact with blood cells, and initiate tissue repair. The fibrin network is porous and highly permeable, but the spatial arrangement of the external clot face is unknown. Here we show that fibrin transitioned to the blood-air interface through Langmuir film formation, producing a protective film confining the clot. We demonstrated that only fibrin is required to form the film, and that it occurred in vitro and in vivo...
May 3, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29719379/comparison-of-tadalafil-pharmacokinetics-after-administration-of-a-new-orodispersible-film-versus-a-film-coated-tablet
#10
Sang-In Park, Su-Hak Heo, Gihwan Kim, Seokhoon Chang, Keon-Hyoung Song, Min-Gul Kim, Eun-Heui Jin, JaeWoo Kim, SeungHwan Lee, Jang Hee Hong
Background: An orodispersible film (ODF) of tadalafil may provide increased convenience for erectile dysfunction (ED) patients as compared to conventional tablet formulations. In this study, we aimed to compare the pharmacokinetic, safety, and tolerability profiles of a newly developed ODF formulation of tadalafil to those of a film-coated tablet (FCT) of tadalafil. Materials and methods: This study was conducted in healthy male subjects using an open-label, randomized sequence, two-period, two-formulation, single-dose, crossover design...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29712433/bilirubin-nanoparticle-assisted-delivery-of-a-small-molecule-drug-conjugate-for-targeted-cancer-therapy
#11
Soyoung Lee, Yonghyun Lee, Hyungjun Kim, Dong Yun Lee, Sangyong Jon
Despite growing interest in targeted cancer therapy with small molecule drug conjugates (SMDCs), the short half-life of these conjugates in blood associated with their small size has limited their efficacy in cancer therapy. In this report, we propose a new approach for improving the antitumor efficacy of SMDCs based on nanoparticle-assisted delivery. Ideally, a nanoparticle-based delivery vehicle would prolong the half-life of an SMDC in blood and then release it in response to stimuli in the tumor microenvironment (TME)...
April 30, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29704642/verapamil-and-riluzole-cocktail-liposomes-overcome-pharmacoresistance-by-inhibiting-p-glycoprotein-in-brain-endothelial-and-astrocyte-cells-a-potent-approach-to-treat-amyotrophic-lateral-sclerosis
#12
Tianzhi Yang, Laine Ferrill, Leanne Gallant, Sarah McGillicuddy, Tatiana Fernandes, Nicole Schields, Shuhua Bai
Riluzole is currently one of two approved medications for the treatment of amyotrophic lateral sclerosis (ALS). However, brain disposition of riluzole, as a substrate of P-glycoprotein (P-gp), is limited by the efflux transporters at the blood-brain barrier (BBB). We propose to develop a liposomal co-delivery system that could effectively transport riluzole to brain cells by reducing efflux pumps with a P-gp inhibitor, verapamil. Riluzole and verapamil cocktail liposomes were prepared by lipid film hydration...
April 25, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29702391/novel-biosensing-system-for-the-simultaneous-multiplex-fluorescent-determination-of-catecholamines-and-their-metabolites-in-biological-liquids
#13
Maria I Makedonskaya, Irina A Veselova, Stepan N Kalmykov, Tatiana N Shekhovtsova
A novel original biosensing system for the simultaneous multiplex determination of general markers of catecholamine-producing diseases - catecholamines (dopamine, epinephrine, norepinephrine) and their metabolites (homovanillic and vanillylmandelic acids) in biological liquids without preliminary separation of analytes, in the absence of specific antibodies and receptors and with minimum pretreatment of a samples has been developed. This outstanding approach includes the unique combination of obtaining highly fluorescent derivatives of the analytes as a result of their interaction with two different amines ̶ benzylamine and 1,2-diphenylethylenediamine in the presence of peroxidase as a catalyst, with the application of first-order derivative fluorescence spectroscopy for the resolution of their spectra...
April 21, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29695724/simultaneous-lancet-free-monitoring-of-alcohol-and-glucose-from-low-volumes-of-perspired-human-sweat
#14
Ashlesha Bhide, Sriram Muthukumar, Amreek Saini, Shalini Prasad
A lancet-free, label-free biosensor for simultaneous detection of sweat glucose and alcohol was demonstrated using zinc oxide thin films integrated into a nanoporous flexible electrode system. Sensing was achieved from perspired human sweat at low volumes (1-3 μL), comparable to ambient conditions without external stimulation. Zinc oxide thin film electrodes were surface functionalized with alcohol oxidase enzyme and with glucose oxidase enzyme towards developing an affinity biosensor specific to the physiological relevant range of alcohol comprising of 0-2 drinks (0-50 mg/dl) and physiologically relevant range of glucose ranging from hypo- to hyper-glycaemia (50-130 mg/dl) in perspired human sweat...
April 25, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29689396/in-situ-decompression-to-spinal-cord-during-anterior-controllable-antedisplacement-fusion-treating-degenerative-kyphosis-with-stenosis-surgical-outcomes-and-analysis-of-c5-nerve-palsy-based-on-49-patients
#15
Haisong Yang, Jingchuan Sun, Jiangang Shi, Yong Yang, Yongfei Guo, Bing Zheng, Yuan Wang
OBJECTIVE: To observe outcomes of anterior controllable antedisplacement fusion (ACAF) in the treatment for degenerative kyphosis with stenosis (DKS) and analyze the probability of C5 nerve palsy. METHODS: In the period from 2016 to 2017, a consecutive cohort of adults with DKS underwent ACAF. All these patients were performed cervical plain films, CT and MRI. The operation duration, blood loss and hospital stay was estimated. Radiologic assessment included kyphotic correction, decompression width and spinal canal area...
April 21, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29684748/silk-fibroin-as-a-platform-for-dual-sensing-of-vitamin-b-12-using-photoluminescence-and-electrical-techniques
#16
Sudesna Chakravarty, Bedanta Gogoi, Biman B Mandal, Nandana Bhardwaj, Neelotpal Sen Sarma
The amalgamation of natural origin materials and technologies for label-free and real time detection is pertinent in analytical field. In this study, Bombyx mori silk fibroin protein (BMSF) has been utilized for the dual sensing of vitamin B12 via fluorescence and electrical impedance techniques. The processing of BMSF is done to generate an aqueous solution of BMSF along with the development of micro patterned thin films via soft lithography technique. The BMSF aqueous solution exhibit auto fluorescence property and thereby utilized for label free detection of vitamin B12 with an estimated limit of detection (LOD) of about 0...
March 28, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29682769/biophysical-measurement-of-red-blood-cells-by-lab-on-pcb-chip
#17
Ying Zhao, Wengeng Zhang
Microfluidic impedance pulse sensor has emerged as easy-handling and low-cost platform in the electrical analysis of biological cells. In the conventional method, impedance sensor demanded expensively patterning metal electrodes on the substrate, which are directly in touch with electrolytes in order to measure the microfluidic channel impedance change. In this letter, a cost-effective microfluidic impedance sensor building upon a dielectric film coated printed circuit board is introduced. Impedance electrodes are protected by a dielectric film layer from electrochemical erosion between electrodes and electrolyte...
April 22, 2018: Electrophoresis
https://www.readbyqxmd.com/read/29678190/neonatal-and-congenital-malaria-a-case-series-in-malaria-endemic-eastern-uganda
#18
Peter Olupot-Olupot, Emma I E Eregu, Ketty Naizuli, Julie Ikiror, Linda Acom, Kathy Burgoine
BACKGROUND: Congenital malaria is the direct infection of an infant with malaria parasites from their mother prior to or during birth. Neonatal malaria is due to an infective mosquito bite after birth. Neonatal and congenital malaria (NCM) are potentially life-threatening conditions that are believed to occur at relatively low rates in malaria endemic regions. However, recent reports suggest that the number of NCM cases is increasing, and its epidemiology remains poorly described. NCM can mimic other neonatal conditions and because it is thought to be rare, blood film examinations for malaria are not always routinely performed...
April 20, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29677767/effect-of-substrate-roughness-on-adhesion-and-structural-properties-of-ti-ni-shape-memory-alloy-thin-film
#19
Donghwan Kim, Hyunsuk Lee, Joohyeon Bae, Hyomin Jeong, Byeongkeun Choi, Taehyun Nam, Jungpil Noh
Ti-Ni shape memory alloy (SMA) thin films are very attractive material for industrial and medical applications such as micro-actuator, micro-sensors, and stents for blood vessels. An important property besides shape memory effect in the application of SMA thin films is the adhesion between the film and the substrate. When using thin films as micro-actuators or micro-sensors in MEMS, the film must be strongly adhered to the substrate. On the other hand, when using SMA thin films in medical devices such as stents, the deposited alloy thin film must be easily separable from the substrate for efficient processing...
September 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29670410/pharmacokinetic-equivalence-study-of-nonsteroidal-anti-inflammatory-drug-etoricoxib
#20
Raymond R Tjandrawinata, Arini Setiawati, Dwi Nofiarny, Liana W Susanto, Effi Setiawati
Purpose: The current study aimed to evaluate whether a generic product of etoricoxib 120 mg film-coated tablet (the test drug) was bioequivalent to the reference product (Arcoxia® film-coated tablet 120 mg). Methods: This was a randomized, open-label, two-sequence, crossover study under fasting condition, with a 14-day washout period, involving 26 healthy adult male and female subjects. Blood samples were taken and analyzed for plasma concentrations of etoricoxib (Chemical Abstracts Service [CAS] 202409-33-4) using a high-pressure liquid chromatography-ultraviolet detector (HPLC-UV) system capable of measuring etoricoxib concentrations ranging from 5...
2018: Clinical Pharmacology: Advances and Applications
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