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Blood film

Tunga Salthammer, Yinping Zhang, Jinhan Mo, Holger M Koch, Charles J Weschler
There is an ongoing probing of the role of chemicals in the indoor environment. The majority of potential target substances are so-called very volatile, volatile and semi volatile organic compounds (VVOCs, VOCs and SVOCs). Depending on their physical properties and mass transfer conditions, they distribute in or between the gas phase, particle phase, settled house dust, surface films, clothing and other fabrics as well as the exposed skin and hair of the occupants themselves. Therefore, inhalation, ingestion and dermal uptake all must be considered as relevant pathways for the exposure assessment in human habitats...
March 14, 2018: Angewandte Chemie
Takahiro Tadokoro, Manabu Kakinohana, Michael Navarro, Motoaki Goya, Yuichiro Odo
BACKGROUND: Insufficient fixation of an epidural catheter may result in migration of the catheter and eventual catheter failure. However, the best fixation method remains to be established. Aron Alpha A (2-ethyl cyanoacrylate) adhesive is approved for clinical use and can be used for surgical adhesion to both skin and blood vessels. We hypothesized that the addition of Aron Alpha A adhesive to film dressing would result in consistent and dependable catheter fixation. METHODS: In this study, 58 women who were scheduled for cesarean delivery under spinal and epidural anesthesia were recruited...
March 12, 2018: Anesthesia and Analgesia
Edyta Matysiak-Brynda, Barbara Wagner, Michał Bystrzejewski, Ireneusz P Grudzinski, Anna M Nowicka
The way of immobilization of the monoclonal antibody (type IgG) on the electrode surface has a significant effect on the amount of the immobilized protein and in consequence on current signal of protein. Herein, we demonstrate that the application of appropriately functionalized phenyl film allowed us to control the orientation of the antibody (Ab) molecules on the electrode surface. The influence of Ab orientation on the efficiency of antigen-antibody interaction was tested with an example blood plasma protein (ferritin; Ft)...
March 5, 2018: Biosensors & Bioelectronics
Shima Gholizadeh, Emmy M Dolman, Rebecca Wieriks, Rolf W Sparidans, Wim E Hennink, Robbert J Kok
PURPOSE: Sepantronium bromide (YM155) is a hydrophilic quaternary compound that cannot be administered orally due to its low oral bioavailability; it is furthermore rapidly eliminated via the kidneys. The current study aims at improving the pharmacokinetic profile of YM155 by its formulation in immunoliposomes that can achieve its enhanced delivery into tumor tissue and facilitate uptake in neuroblastoma cancer cells. METHODS: PEGylated YM155 loaded liposomes composed of DPPC, cholesterol and DSPE-PEG2000 were prepared via passive film-hydration and extrusion method...
March 7, 2018: Pharmaceutical Research
Hosein Azimian, Mahdieh Dayyani, Mohammad Taghi Bahreyni Toossi, Mahmoud Mahmoudi
Objectives: Radiotherapy is one of the most effective modalities of cancer therapy, but clinical responses of individual patients varies considerably. To enhance treatment efficiency it is essential to implement an individual-based treatment. The aim of present study was to identify the mechanism of intrinsic apoptosis pathway on radiosensitivity and normal tissue complications caused by the radiotherapy. Materials and Methods: Peripheral blood mononuclear cells from ten breast cancer patients were exposed to 6MV X-rays to deliver 1 and 2 Gy...
March 2018: Iranian Journal of Basic Medical Sciences
C Yuan-Yuan, Z Guo-Ding, G U Ya-Ping, X U Xiang-Zhen, J Xiao-Lin, Z Hua-Yun, W Jie, L You-Sheng, Y Kun, C Jun
Objective To understand the integrated ability of parasitic disease prevention and control of professional personnel of Jiangsu Province through the contest. Methods Totally 56 players from the whole province were selected, and all the players participated in the contest. The theory knowledge and skill scores were collected and the statistical analyses were conducted. Results The average theoretical score of the participants was 88.86±15.56 and the passing rate was 91.1%. The average skill operating score was 69...
March 21, 2017: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
Luca Ampollini, Elisabetta Barocelli, Andrea Cavazzoni, Piergiorgio Petronini, Claudio Mucchino, Anna Maria Cantoni, Fabio Leonardi, Luigi Ventura, Stefano Barbieri, Paolo Colombo, Antonella Fusari, Paolo Carbognani, Michele Rusca, Fabio Sonvico
Background: Malignant pleural mesothelioma (MPM) continues to be a distressing tumor due to its aggressive biologic behavior and scanty prognosis. Several therapeutic approaches have been tested both in clinical and preclinical settings, being intrapleural chemotherapy one of the most promising. Some years ago, our interest focused on polymeric films loaded with cisplatin for the adjuvant intrapleural treatment of surgical patients. After in vitro and in vivo studies in a rat recurrence model of MPM, the aim of this study was to evaluate the pharmacokinetics of the polymeric films in a sheep model in view of further studies in a clinical setting...
January 2018: Journal of Thoracic Disease
Victor Selin, Victoria Albright, John F Ankner, Alexander Marin, Alexander K Andrianov, Svetlana A Sukhishvili
Nonionic fluorinated polyphosphazenes, such as poly[bis(trifluoroethoxy)phosphazene] (PTFEP), display superb biocompatibility, yet their deposition to surfaces has been limited to solution casting from organic solvents or thermal molding. Herein, hydrophobic coatings of fluorinated polyphosphazenes are demonstrated through controlled deposition of ionic fluorinated polyphosphazenes (iFPs) from aqueous solutions using the layer-by-layer (LbL) technique. Specifically, the assemblies included poly[(carboxylatophenoxy)(trifluoroethoxy) phosphazenes] with varied content of fluorine atoms as iFPs (or poly[bis(carboxyphenoxy) phosphazene] (PCPP) as a control nonfluorinated polyphosphazene) and a variety of polycations...
March 5, 2018: ACS Applied Materials & Interfaces
Zida Li, Yize Wang, Xufeng Xue, Brendan McCracken, Kevin Ward, Jianping Fu
Coagulation monitoring is essential for perioperative care and thrombosis treatment. However, existing assays for coagulation monitoring have limitations such as a large footprint and complex setup. In this work, we developed a miniaturized device for point-of-care blood coagulation testing by measuring dynamic clot retraction force development during blood clotting. In this device, a blood drop was localized between a protrusion and a flexible force-sensing beam to measure clot retraction force. The beam was featured with micropillar arrays to assist the deposition of carbon nanotube films, which served as a strain sensor to achieve label-free electrical readout of clot retraction force in real time...
February 27, 2018: ACS Sensors
Ewurama D A Owusu, Samson K Djonor, Charles A Brown, Martin P Grobusch, Petra F Mens
BACKGROUND: Plasmodium falciparum, the most dominant species in sub-Saharan Africa, causes the most severe clinical malaria manifestations. In resource-limited Ghana, where malaria and HIV geographically overlap, histidine-rich protein 2 (HRP2)-based rapid diagnostic test (RDT) is a faster, easier and cheaper alternative to clinical gold standard light microscopy. However, mutations in parasite hrp2 gene may result in missed infections, which have severe implications for malaria control...
February 23, 2018: Malaria Journal
Zhang Juan-Sheng, Zhang Di-Qiang, Wang Wei, Wei Xiao-Guang, Wang Zeng-Guo
This paper reviews the computer vision and image analysis studies aiming at automated diagnosis or screening of malaria in microscope images of thin blood film smears. On the basis of introducing the background and significance of automatic detection technology, the existing detection technologies are summarized and divided into several steps, including image acquisition, pre-processing, morphological analysis, segmentation, count, and pattern classification components. Then, the principles and implementation methods of each step are given in detail...
May 5, 2017: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
Zi-Kun He, Jing-An Li, Xiao Luo, Dan Zou, Ping Yang, An-Sha Zhao, Nan Huang
The TiO2 nanotube has been anticipated for potential application for cardiovascular implanted devices for its excellent drug loading/release function and biocompatibility. However, its mechanical behavior has rarely been studied as the cardiovascular devices. The tube length is a crucial factor which not only decides the drug loading ability but also influences the devices' mechanical behavior. Therefore, in this work, the TiO2 nanotubes with different tube length (NT2, NT4 and NT6) were fabricated, and their surface energy, residual stress, tensile tolerability and blood flow shear stress tolerability were determined, respectively...
February 1, 2018: Journal of Nanoscience and Nanotechnology
Lucy Fox, Solomon J Cohney, Joshua Y Kausman, Jake Shortt, Peter D Hughes, Erica M Wood, Nicole M Isbel, Theo de Malmanche, Anne Durkan, Pravin Hissaria, Piers Blombery, Thomas D Barbour
Thrombotic microangiopathy (TMA) arises in a variety of clinical circumstances with the potential to cause significant dysfunction of the kidneys, brain, gastrointestinal tract and heart. TMA should be considered in all patients with thrombocytopenia and anaemia, with an immediate request to the haematology laboratory to look for red cell fragments on a blood film. Whilst TMA of any aetiology generally demands prompt treatment, this is especially so in thrombotic thrombocytopenic purpura (TTP) and atypical haemolytic uraemic syndrome (aHUS), where organ failure may be precipitous, irreversible and fatal...
February 8, 2018: Nephrology
Masatsugu Kimura, Isao Teramoto, Chim W Chan, Zulkarnain Md Idris, James Kongere, Wataru Kagaya, Fumihiko Kawamoto, Ryoko Asada, Rie Isozumi, Akira Kaneko
BACKGROUND: Rapid diagnosis of malaria using acridine orange (AO) staining and a light microscope with a halogen lamp and interference filter was deployed in some malaria-endemic countries. However, it has not been widely adopted because: (1) the lamp was weak as an excitation light and the set-up did not work well under unstable power supply; and, (2) the staining of samples was frequently inconsistent. METHODS: The halogen lamp was replaced by a low-cost, blue light-emitting diode (LED) lamp...
February 7, 2018: Malaria Journal
Sung Hwa Song, Ji Eun Kim, Eun Kyoung Koh, Ji Eun Sung, Hyun Ah Lee, Woo Bin Yun, Jin Tae Hong, Dae Youn Hwang
PURPOSE: Aims of this study is to evaluate the therapeutic effects and toxicity of Se-loaded cellulose film originated from Styela clava tunic (SeSCTF) on cutaneous wounds during diabetic conditions. MATERIALS AND METHODS: Alterations in skin regeneration, angiogenesis and toxicity were examined using streptozotocine (STZ)-induced diabetic Sprague Dawley® (SD) rats with surgical skin wounds after application of SeSCTF for 12 days. RESULTS: SCTF showed high tensile strength (1...
February 7, 2018: Journal of Dermatological Treatment
Michelle C White, Linden S Baxter, Kristin L Close, Vaonandianina A Ravelojaona, Hasiniaina N Rakotoarison, Emily Bruno, Alison Herbert, Vanessa Andean, James Callahan, Hery H Andriamanjato, Mark G Shrime
BACKGROUND: The 2009 World Health Organisation (WHO) surgical safety checklist significantly reduces surgical mortality and morbidity (up to 47%). Yet in 2016, only 25% of East African anesthetists regularly use the checklist. Nationwide implementation of the checklist is reported in high-income countries, but in low- and middle-income countries (LMICs) reports of successful implementations are sparse, limited to single institutions and require intensive support. Since checklist use leads to the biggest improvements in outcomes in LMICs, methods of wide-scale implementation are needed...
2018: PloS One
Kamal Dua, Dyandevi Mathure, Jyotsana R Madan, Kishore N Gujar, Ashok Tupsamundre, Hemant A Ranpise
Considering various merits associated with the nasal mucosa such large surface area, porous endothelial membrane, high blood flow, avoidance of first-pass metabolism, and ready accessibility leads to faster and higher drug absorption. Keeping these facts in mind, the objective of the present study was to develop Buspirone hydrochloride loaded niosomal in-situ nasal gel. Buspirone hydrochloride niosomal in-situ nasal gel was formulated, optimized and evaluated with the aim to deliver drug to the brain via intranasal route...
January 29, 2018: Pharmaceutical Nanotechnology
Vasantha Muthu Muthuppalaniappan, Ravindra Rajakariar, Mark John Blunden
BACKGROUND: Leptospirosis is a rare infectious disease especially in Western Countries. Renal involvement is a recognised complication of leptospirosis but leptospirosis-associated haemolytic uraemic syndrome is extremely rare and to our knowledge has only been reported once, in 1985. CASE PRESENTATION: A 29-year-old male was transferred to our Renal Unit with fevers, myalgia and diarrhoeal illness. Laboratory investigations revealed an acute kidney injury, acute liver injury, significantly raised lactate dehydrogenase with marked anaemia, thrombocytopenia and schistocytes on a blood film...
January 29, 2018: BMC Nephrology
Tiago D Gomes, Sofia G Caridade, Maria P Sousa, Sara Azevedo, Muhammed Y Kandur, Ebru T Öner, Natália M Alves, João F Mano
This work is the first reporting the use of layer-by-layer to produce adhesive free-standing (FS) films fully produced using natural-based macromolecules: chitosan (CHI), alginate (ALG) and sulfated levan (L-S). The deposition conditions of the natural polymers were studied through zeta potential measurements and quartz crystal microbalance with dissipation monitoring analysis. The properties of the FS films were evaluated and compared with the control ones composed of only CHI and ALG in order to assess the influence of levan polysaccharide introduced in the multilayers...
January 26, 2018: Acta Biomaterialia
Horacio Vieyra, Esmeralda Juárez, Ulises Figueroa, Andrea Guevara, Martha Torres
Implants of materials that are typically considered inert have been shown to cause early inflammatory complications. In addition, implant wear products may also cause overproduction of proinflammatory cytokines in the long run. Among the cytokines is TNFα, which not only participates in the inflammatory response but also in the degradation of the bone. Therefore, a lack of production of TNFα by the cells of the immune system in contact with a candidate material for implant design is an indication of the acceptance of the biomaterial, and predicts the inflammatory response responsible for implant intolerance...
January 29, 2018: Biomedical Materials
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