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https://www.readbyqxmd.com/read/28442892/bioequivalence-study-of-a-new-sildenafil-100-mg-orodispersible-film-compared-to-the-conventional-film-coated-100-mg-tablet-administered-to-healthy-male-volunteers
#1
Milko Radicioni, Chiara Castiglioni, Andrea Giori, Irma Cupone, Valeria Frangione, Stefano Rovati
A new orodispersible film formulation of the phosphodiesterase type 5 inhibitor, sildenafil, has been developed to examine the advantages of an orally disintegrating film formulation and provide an alternative to the current marketed products for the treatment of erectile dysfunction. The pharmacokinetics of the sildenafil 100 mg orodispersible film (IBSA) was compared to that of the conventional marketed 100 mg film-coated tablet (Viagra(®)) after single-dose administration to 53 healthy male volunteers (aged 18-51 years) in a randomized, open, two-way crossover bioequivalence study...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28442321/high-prevalence-of-plasmodium-falciparum-and-soil-transmitted-helminth-co-infections-in-a-periurban-community-in-kwara-state-nigeria
#2
Olarewaju A Babamale, Uade S Ugbomoiko, Jorg Heukelbach
Prevalence of malaria and soil-transmitted helminth infections, and the burden of disease are enormous in sub-Saharan Africa. Co-infections aggravate the clinical outcome, but are common due to an overlap of endemic areas. A cross-sectional survey was conducted to assess prevalence, intensity of infection and association between malaria and soil-transmitted helminth infections in a typical periurban community in Kwara State. Fresh blood and faecal samples were examined using thick blood film and Kato-Katz smear techniques...
April 22, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28440618/design-of-antibacterial-polyethersulfone-membranes-via-covalently-attaching-hydrogel-thin-layers-loaded-with-ag-nanoparticles
#3
Min He, Qian Wang, Rui Wang, Yi Xie, Weifeng Zhao, Changsheng Zhao
In order to inhibit the bacteria attachment and the subsequent formation of bio-films on polyethersulfone (PES) membranes, poly(sulfobetaine methacrylate) (PSBMA)/poly(sodium acrylate) (PAANa) antibacterial hydrogel thin layers were covalently attached onto the membranes, followed by loading Ag nanoparticles. In our strategy, double bonds were firstly introduced onto PES membrane surfaces to provide anchoring sites, and then the hydrogel layers were synthesized on the membrane surfaces via UV light initiated cross-linking copolymerization...
April 25, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28438159/prevalence-of-plasmodium-falciparum-and-non-p-falciparum-infections-in-a-highland-district-in-ghana-and-the-influence-of-hiv-and-sickle-cell-disease
#4
Ewurama D A Owusu, Charles A Brown, Martin P Grobusch, Petra Mens
BACKGROUND: In the past two decades, there has been a reported decline in malaria in Ghana and the rest of the world; yet it remains the number one cause of mortality and morbidity. Human immuno-deficiency virus (HIV) and sickle cell disease (SCD) share a common geographical space with malaria in sub-Saharan Africa and an interaction between these three conditions has been suggested. This study determined the Plasmodium falciparum and non-P. falciparum status of symptomatic and non-symptomatic residents of Mpraeso in the highlands of Kwahu-South district of Ghana based on evidence of current national decline...
April 24, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28438085/the-feline-blood-film
#5
John W Harvey
Practical relevance: Many veterinary practices have invested in quality automated hematology instruments for use in-house. However, regardless of the specific choice of analyzer, there are important hematology findings that can only be determined by microscopic examination of stained blood films. For this reason, and also for the purpose of quality control for the analyzer, a quick blood film review should be performed alongside every automated complete blood count. Even those practices that submit their blood samples to outside diagnostic laboratories for evaluation, still require the capability to examine stained blood films in emergency situations...
May 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/28437084/affinity-binding-of-emr2-expressing-cells-by-surface-grafted-chondroitin-sulfate-b
#6
Anouck L S Burzava, Marek Jasieniak, Michaelia P Cockshell, Claudine S Bonder, Frances J Harding, Hans Joerg Griesser, Nicolas H Voelcker
The propensity of glycosaminoglycans to mediate cell-cell and cell-matrix interactions opens the door to capture cells, including circulating blood cells, onto biomaterial substrates. Chondroitin sulfate (CS) -B is of particular interest, since it interacts with the receptor (EGF)-like module-containing mucin-like hormone receptor-like 2 precursor (EMR2) displayed on the surface of leukocytes and endothelial progenitor cells. Herein, CS-B and its isomer CS-A were covalently immobilized onto heptylamine plasma polymer films via three different binding chemistries to develop platform technology for the capture of EMR2 expressing cells onto solid carriers...
April 24, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28415459/the-effect-of-hirudin-modification-of-silk-fibroin-on-cell-growth-and-antithrombogenicity
#7
Qiongyu Wang, Fangfang Tu, Yunfei Liu, Yujin Zhang, Helei Li, Zhao Kang, Yin Yin, Jiannan Wang
Thrombus formation remains a particular challenge for small-diameter vascular grafts. In this study, the direct thrombin inhibitor hirudin (Hir) was used to modify silk fibroin films in an attempt to enhance its antithrombogenic properties. Hir was successfully attached to silk fibroin and uniformly distributed in the regenerative material. Hir-modified films showed good cytocompatibility, and supported adhesion and proliferation of fibroblasts (L929), human umbilical vascular endothelial cells (HUVECs) and human aortic smooth muscle cells (HASMCs)...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28414907/cell-isolation-and-recovery-using-hollow-glass-microspheres-coated-with-nanolayered-films-for-applications-in-resource-limited-settings
#8
Ziye Dong, Caroline C Ahrens, Dan Yu, Zhenya Ding, HyunTaek Lim, Wei Li
Established cell isolation and purification techniques such as fluorescence-activated cell sorting (FACS), isolation through magnetic micro/nanoparticles, and recovery via microfluidic devices have limited application as disposable technologies appropriate for point-of-care use in remote areas where lab equipment as well as electrical, magnetic, and optical sources are restricted. We report a simple yet effective method for cell isolation and recovery that requires neither specialized lab equipment nor any form of power source...
April 26, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28409633/tunable-nitric-oxide-release-from-s-nitroso-n-acetylpenicillamine-via-catalytic-copper-nanoparticles-for-biomedical-applications
#9
Jitendra Pant, Marcus J Goudie, Sean P Hopkins, Elizabeth J Brisbois, Hitesh Handa
The quest for novel therapies to prevent bacterial infections and blood clots (thrombosis) is of utmost importance in biomedical research due to the exponential growth in the cases of thrombosis and blood infections and the emergence of multi-drug-resistant strains of bacteria. Endogenous nitric oxide (NO) is a cellular signaling molecule that plays a pivotal role in host immunity against pathogens, prevention of clotting, and regulation of systemic blood pressure, among several other biological functions. The physiological effect of NO is dose dependent, which necessitates the study of its tunable release kinetics, which is the objective of this study...
April 26, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28409627/simultaneous-atr-ftir-based-determination-of-malaria-parasitemia-glucose-and-urea-in-whole-blood-dried-onto-a-glass-slide
#10
Supti Roy, David Perez-Guaita, Dean W Andrew, Jack S Richards, Don McNaughton, Philip Heraud, Bayden R Wood
New diagnostic tools that can detect malaria parasites in conjunction with other diagnostic parameters are urgently required. In this study, Attenuated Total Reflection Fourier transform infrared (ATR-FTIR) spectroscopy in combination with Partial Least Square Discriminant Analysis (PLS-DA) and Partial Least Square Regression (PLS-R) have been applied as a point-of-care test for identifying malaria parasites, blood glucose and urea levels in whole blood samples from thick blood films on glass slides. The specificity for the PLS-DA was found to be 98 % for parasitemia levels >0...
April 14, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28408818/anti-inflammatory-activity-of-niosomes-entrapped-with-plai-oil-zingiber-cassumunar-roxb-by-therapeutic-ultrasound-in-a-rat-model
#11
Jirakrit Leelarungrayub, Jiradej Manorsoi, Aranya Manorsoi
OBJECTIVE: The aim of this study was to evaluate the antioxidant and anti-inflammatory activities of Plai oil-encapsulated niosomes (Zingiber cassumunar Roxb.) on inflamed subcutaneous Wistar rat skin by therapeutic ultrasound. METHODS: Pure oil from Plai rhizomes was extracted by steam distillation, and antioxidant activities were determined by 2,2-diphenyl-1-picrylhydrazyl radical scavenging assay. Bioactive compounds were analyzed by gas chromatography-mass spectrometry...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28404673/update-on-malaria-diagnostics-and-test-utilization
#12
Blaine A Mathison, Bobbi S Pritt
Malaria is a potentially life-threatening disease requiring rapid diagnosis and treatment. Although microscopic examination of thick and thin blood films remains the gold standard for laboratory diagnosis, rapid antigen tests and nucleic acid amplification methods may also play a useful role for detection of acute infection. This review discusses the advantages and disadvantages of the commonly-used diagnostic methods and provides important practice points for optimal malaria test utilization.
April 12, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28402702/comparison-of-the-tight-rope-technique-and-clavicular-hook-plate-for-the-treatment-of-rockwood-type-iii-acromioclavicular-joint-dislocation
#13
Leyi Cai, Te Wang, Di Lu, Wei Hu, Jianjun Hong, Hua Chen
AIM: Acromioclavicular joint dislocation is one of the most common shoulder problems and may lead to instability or degenerative changes. The aim of this study was to compare the clinical outcomes of the Tight Rope system and clavicular hook plate for Rockwood type III acromioclavicular joint dislocation in adults. MATERIALS AND METHODS: This was a prospective, randomized study in a hospital setting. From January 2012 to December 2014, 69 patients with type III injury were reviewed...
April 12, 2017: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/28402205/non-ionic-surfactant-based-thymoquinone-loaded-nanoproniosomal-formulation-in-vitro-physicochemical-evaluation-and-in-vivohepatoprotective-efficacy
#14
Sanowar Sayeed, Syed Sarim Imam, Abul Kalam Najmi, Mohd Aqil, Mohd Akhtar
CONTEXT: The present study was carried out to formulate thymoquinone proniosomal formulation (TQP) and evaluate their efficacy in methotrexate (Mtx) induced hepatotoxicity in rats. OBJECTIVE: Theobjective of the study was to explore a new therapeutic approach focusing on hepatoprotectiveactivity using thymoquinone proniosomal formulation. MATERIAL AND METHODS: TQP was formulated using span60, cholesterol and phospholipid by film hydration technique...
April 12, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28399686/prevalence-of-congenital-malaria-in-newborns-of-mothers-co-infected-with-hiv-and-malaria-in-benin-city
#15
Fidelis Ewenitie Eki-Udoko, Ayebo E Sadoh, Michael O Ibadin, Augustine I Omoigberale
BACKGROUND: HIV and Plasmodium falciparum malaria co-infection annually complicates about one million pregnancies in sub-Saharan Africa. Congenital malaria (CM) has deleterious effects on newborns. Little is known about the effect of co-infections on the prevalence of CM in infants born by these women. This study was carried out to determine the prevalence of CM in newborns of mothers co-infected with HIV and malaria compared to HIV-negative mothers with malaria in Benin-City. METHODS: Subjects were 162 newborns of mothers co-infected with HIV and malaria...
April 11, 2017: Infectious Diseases
https://www.readbyqxmd.com/read/28398221/amyloid-fibrils-from-hemoglobin
#16
Nadishka Jayawardena, Manmeet Kaur, Smitha Nair, Jenny Malmstrom, David Goldstone, Leonardo Negron, Juliet A Gerrard, Laura J Domigan
Amyloid fibrils are a class of insoluble protein nanofibers that are formed via the self-assembly of a wide range of peptides and proteins. They are increasingly exploited for a broad range of applications in bionanotechnology, such as biosensing and drug delivery, as nanowires, hydrogels, and thin films. Amyloid fibrils have been prepared from many proteins, but there has been no definitive characterization of amyloid fibrils from hemoglobin to date. Here, nanofiber formation was carried out under denaturing conditions using solutions of apo-hemoglobin extracted from bovine waste blood...
April 11, 2017: Biomolecules
https://www.readbyqxmd.com/read/28394455/flexible-blade-coated-multicolor-polymer-light-emitting-diodes-for-optoelectronic-sensors
#17
Donggeon Han, Yasser Khan, Jonathan Ting, Simon M King, Nir Yaacobi-Gross, Martin J Humphries, Christopher J Newsome, Ana C Arias
A method to print two materials of different functionality during the same printing step is presented. In printed electronics, devices are built layer by layer and conventionally only one type of material is deposited in one pass. Here, the challenges involving printing of two emissive materials to form polymer light-emitting diodes (PLEDs) that emit light of different wavelengths without any significant changes in the device characteristics are described. The surface-energy-patterning technique is utilized to print materials in regions of interest...
April 10, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28392863/efficacy-of-intravenous-administration-of-landiolol-in-patients-with-acute-heart-failure-and-supraventricular-tachyarrhythmia
#18
Shunsuke Kiuchi, Hiroto Aikawa, Shinji Hisatake, Takayuki Kabuki, Takashi Oka, Shintaro Dobashi, Takahiro Fujii, Takanori Ikeda
BACKGROUND: Patients with acute heart failure (HF) complicated by supraventricular tachyarrhythmia (SVT) often receive continuous intravenous infusion of landiolol or diltiazem for rate control. It is unclear whether the interval from initiation of infusion to commencement of oral beta-blocker (BB) therapy differs for these two drugs. METHODS: From January 2013 to July 2015, 94 consecutive patients were hospitalized for acute HF complicated by SVT. After 35 patients were excluded, the remaining 59 were divided into groups treated with diltiazem or landiolol...
May 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28388959/autosomal-recessive-inherited-bleeding-disorders-in-pakistan-a-cross-sectional-study-from-selected-regions
#19
Arshi Naz, Muhammad Younus Jamal, Samina Amanat, Ikram Din Ujjan, Akber Najmuddin, Humayun Patel, Fazle Raziq, Nisar Ahmed, Ayisha Imran, Tahir Sultan Shamsi
BACKGROUND: Autosomal recessive bleeding disorders (ARBDs) include deficiencies of clotting factors I, II, V, VII, X, XI, XIII, vitamin K dependent clotting factors, combined factor V & VIII, Von Willebrand Disease (vWD) type 3, Glanzmann's thrombasthenia (GT) and Bernard-Soulier syndrome. Patients with primary bleeding disorders from all the major provincial capitals of Pakistan were screened for ARBDs. Prothrombin (PT), activated partial thromboplastin time (APTT), bleeding time (BT) and fibrinogen levels were measured...
April 7, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/28371488/bioequivalence-study-of-warfarin-in-healthy-chinese-volunteers-with-a-validated-high-performance-liquid-chromatography-mass-spectrometry-method
#20
Wenlong Li, Fanlong Bu, Rong Li, Benjie Wang, Abdul Sami Shaikh, Yunyun Zhang, Ruichen Guo, Rui Zhang
This study was designed to investigate the pharmacokinetics of an innovative film-coated warfarin sodium tablet and to compare it with the marketed sugar-coated warfarin sodium tablet in humans. A single-dose, open-label, randomized, two-way crossover study was performed in 24 healthy Chinese male volunteers. They were administered 2.5 mg of innovative film-coated warfarin sodium tablets or the marketed sugar-coated warfarin sodium tablets. Blood samples were collected at different time points after dosing for investigation of the pharmacokinetics of warfarin in human plasma...
April 3, 2017: Clinical Pharmacology in Drug Development
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