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https://www.readbyqxmd.com/read/29334266/hyaluronic-acid-modified-daunorubicin-plus-honokiol-cationic-liposomes-for-the-treatment-of-breast-cancer-along-with-the-elimination-vasculogenic-mimicry-channels
#1
Rui-Jun Ju, Lan Cheng, Xiao Qiu, Shuang Liu, Xiao-Li Song, Xiao-Ming Peng, Teng Wang, Cui-Qing Li, Xue-Tao Li
BACKGROUND: Breast cancer is an alarming global public health problem and a main cause of cancer-related death in women. Systemic chemotherapy is the most widely used treatment for breast cancer. However, current chemotherapy treatments are far from desirable due to poor targeting specificity, severe side effects, and vasculogenic mimicry (VM). PURPOSE: Hyaluronic acid (HA) modified daunorubicin plus honokiol cationic liposomes were prepared and characterized for treatment of breast cancer by eliminating VM...
January 15, 2018: Journal of Drug Targeting
https://www.readbyqxmd.com/read/29329518/the-use-of-eculizumab-in-gemcitabine-induced-thrombotic-microangiopathy
#2
Vinod Krishnappa, Mohit Gupta, Haikoo Shah, Abhijit Das, Natthavat Tanphaichitr, Robert Novak, Rupesh Raina
BACKGROUND: Thrombotic microangiopathy (TMA) secondary to gemcitabine therapy (GiTMA) is a very rare pathology that carries a poor prognosis, with nearly half of the cases progressing to end stage renal disease. GiTMA is most commonly associated with adenocarcinomas, most notably pancreatic cancers. The mainstay of management is withdrawal of the offending drug and supportive care. Plasmapheresis has a limited role and hemodialysis may help in the management of fluid overload secondary to renal failure...
January 12, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29329075/anticoagulant-polyurethane-substrates-modified-with-poly-2-methacryloyloxyethyl-phosphorylcholine-via-si-ratrp
#3
Cheng Chi, Baohong Sun, Ninglin Zhou, Ming Zhang, Xiaohong Chu, Ping Yuan, Jian Shen
A novel catalyst system of Reverse Atom Transfer Radical Polymerization (RATRP) to prepare Polyurethane (PU) films modified by poly(2-methacryloyloxyethyl phosphorylcholine) (pMPC) was studied in this article. In this system, PU film was pretreated by LaCl3/CA ethanol solution to obtain a hydrated surface allowing more initiators to be immobilized on it. Moreover, complexes composed of silane coupling agent 3-chloropropyltrimethoxysilane (CPTM), chlorhexidine acetate (CA) and lanthanum(III) worked as ligands of copper ions as a whole during RATRP process...
January 8, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29324858/mapping-the-geographical-distribution-of-podoconiosis-in-cameroon-using-parasitological-serological-and-clinical-evidence-to-exclude-other-causes-of-lymphedema
#4
Kebede Deribe, Amuam Andrew Beng, Jorge Cano, Abdel Jelil Njouendo, Jerome Fru-Cho, Abong Raphael Awah, Mathias Esum Eyong, Patrick W Chounna Ndongmo, Emanuele Giorgi, David M Pigott, Nick Golding, Rachel L Pullan, Abdisalan M Noor, Fikre Enquselassie, Christopher J L Murray, Simon J Brooker, Simon I Hay, Peter Enyong, Melanie J Newport, Samuel Wanji, Gail Davey
BACKGROUND: Podoconiosis is a non-filarial elephantiasis, which causes massive swelling of the lower legs. It was identified as a neglected tropical disease by WHO in 2011. Understanding of the geographical distribution of the disease is incomplete. As part of a global mapping of podoconiosis, this study was conducted in Cameroon to map the distribution of the disease. This mapping work will help to generate data on the geographical distribution of podoconiosis in Cameroon and contribute to the global atlas of podoconiosis...
January 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29319442/clinical-signs-treatment-and-prognostic-factors-for-dogs-with-histoplasmosis
#5
Allison G Wilson, Kate S KuKanich, Andrew S Hanzlicek, Mark E Payton
OBJECTIVE To determine the clinical manifestations of histoplasmosis in a large sample of dogs, compare outcomes achieved with fluconazole versus itraconazole, and identify variables available at the time of diagnosis with prognostic value. DESIGN Retrospective case series with nested cohort study. ANIMALS 79 dogs with confirmed histoplasmosis evaluated at 2 veterinary teaching hospitals from 1999 through 2015. PROCEDURES Medical records were reviewed and data extracted regarding clinical signs at evaluation, physical examination findings, clinical laboratory values, other diagnostic test results, treatments, and outcomes...
January 15, 2018: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29301534/submicroscopic-malaria-cases-play-role-in-local-transmission-in-trenggalek-district-east-java-province-indonesia
#6
Heny Arwati, Subagyo Yotopranoto, Etik Ainun Rohmah, Din Syafruddin
BACKGROUND: Trenggalek district is a hypoendemic malaria area with mainly imported cases brought by migrant workers from islands outside Java. During malaria surveillance in 2015, no malaria cases were found microscopically, but some cases were positive by PCR. Therefore, a study was conducted to prove that local malaria transmission still occur. METHODS: The adult villagers were invited to the house of the head of this village to be screened for malaria using aseptic venipuncture of 1 mL blood upon informed consent...
January 5, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29301270/a-fully-integrated-paper-microfluidic-electrochemical-device-for-simultaneous-analysis-of-physiologic-blood-ions
#7
Joon-Hyung Jin, Joon Hyub Kim, Sang Ki Lee, Sam Jin Choi, Chan Won Park, Nam Ki Min
A fully integrated paper microfluidic electrochemical device equipped with three different cation permeable films is developed to determine blood ions (Cl-, Na⁺, K⁺, and Ca2+) at a time. These blood ions that are normally dissolved in the real human blood stream are essential for cell metabolisms and homeostasis in the human body. Abnormal concentration of blood ions causes many serious disorders. The optimized microfluidic device working without any external power source can directly and effectively separate human blood components, and subsequently detect a specific blood ion with minimized interference...
January 1, 2018: Sensors
https://www.readbyqxmd.com/read/29289375/differences-in-perceived-and-physiologic-genital-arousal-between-women-with-and-without-sexual-dysfunction
#8
Ariel B Handy, Amelia M Stanton, Carey S Pulverman, Cindy M Meston
BACKGROUND: Many sexual psychophysiologic studies have failed to find differences in physiologic genital arousal between women with and those without sexual dysfunction. However, differences in self-reported (ie, perceived) measures of genital responses between these 2 groups of women have been noted. AIMS: To determine whether women with and without sexual dysfunction differ on measures of physiologic and perceived genital arousal based on type of analytic technique used, to explore differences in perceived genital arousal, and to assess the relation between physiologic and perceived genital arousal...
January 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29284563/a-novel-ehrlichia-species-in-blood-and-ixodes-ornithorhynchi-ticks-from-platypuses-ornithorhynchus-anatinus-in-queensland-and-tasmania-australia
#9
Alexander W Gofton, Siew-May Loh, Amanda D Barbosa, Andrea Paparini, Amber Gillett, James Macgregor, Charlotte L Oskam, Una M Ryan, Peter J Irwin
Worldwide, Ehrlichia spp. are emerging infectious organisms of domestic animals and people, however, most Ehrlichia spp. naturally infect wildlife reservoirs causing mainly asymptomatic infections. Australian ecosystems have been under-explored for these potentially pathogenic organisms, and recent studies have identified a range of novel Ehrlichia, and their sister genera, Anaplasma and 'Candidatus Neoehrlichia' species, from native Australian ticks. We used bacterial 16S rRNA (16S) next-generation sequencing and genus-specific PCR to profile the bacterial communities in platypus (Ornithorhynchus anatinus) blood samples and platypus ticks (Ixodes ornithorhynchi), and identified a high prevalence of Ehrlichia sequences...
December 24, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29274316/comparative-evaluation-of-neonatal-bilirubin-using-radiometer-whole-blood-co-oximetry-and-plasma-bilirubin-methods-from-roche-diagnostics-and-ortho-clinical-diagnostics
#10
Ian Marie Lano, Andrew W Lyon, Li Wang, Rob Ruskin, Martha E Lyon
BACKGROUND: Clinically significant variation has been reported within and between plasma and whole blood total bilirubin methods used to identify neonates for whom clinical intervention for hyperbilirubinemia may be required. OBJECTIVE: To evaluate total bilirubin measurements between the Radiometer whole blood co-oximeter and plasma bilirubin methods from Roche Diagnostics and Ortho Clinical Diagnostics using neonatal specimens. METHODS: Total bilirubin levels were analyzed by whole blood co-oximetry (Radiometer® ABL90)...
December 20, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/29272995/primary-care-challenges-of-an-obscure-case-of-alice-in-wonderland-syndrome-in-a-patient-with-severe-malaria-in-a-resource-constrained-setting-a-case-report
#11
Benjamin Momo Kadia, Cyril Jabea Ekabe, Ettamba Agborndip
BACKGROUND: "Alice in Wonderland" syndrome (AIWS) is a rare neurological abnormality characterized by distortions of visual perceptions, body schema and experience of time. AIWS has been reported in patients with various infections such as infectious mononucleosis, H1N1 influenza, Cytomegalovirus encephalitis, and typhoid encephalopathy. However, AIWS occurring in a patient with severe malaria is less familiar and could pose serious primary care challenges in a low-income context. CASE PRESENTATION: A 9-year-old male of black African ethnicity was brought by his parents to our primary care hospital because for 2 days he had been experiencing intermittent sudden perceptions of his parents' heads and objects around him either "shrinking" or "expanding"...
December 22, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29260850/langmuir-blodgett-nanoassemblies-of-mos2-au-composite-at-the-air-water-interface-for-dengue-detection
#12
Shipra Solanki, Amrita Soni, Manoj K Pandey, Ashok Biradar, Gajjala Sumana
We report Langmuir Blodgett (LB) films of molybdenum disulphide (MoS2) and gold nanoparticles (AuNPs) composite being utilized as biosensing platform for dengue detection. The LB films of MoS2-AuNPs composite have been transferred from air water interface to the indium tin oxide (ITO) coated glass substrate under optimized conditions. Further, antibodies specific to dengue NS1 antigen were immobilized onto these LB films. The fabricated immunosensor has been explored for NS1 antigen detection in standard samples as well as in spiked sera samples using electrochemical impedance spectroscopy...
December 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29229544/a-new-textured-polyphosphazene-biomaterial-with-improved-blood-coagulation-and-microbial-infection-responses
#13
Li-Chong Xu, Zhongjing Li, Zhicheng Tian, Chen Chen, Harry R Allcock, Christopher A Siedlecki
A new poly[bis(octafluoropentoxy) phosphazene] (OFP) was synthesized for the purpose of blood contacting medical devices. OFP was further either developed into crosslinkable polyphosphazene (X-OFP) or blended with polyurethane (PU) as the mixture (OFP/PU) for improvement of mechanical property of polyphosphazene polymers. All the materials were fabricated as smooth films or further textured with submicron pillars for the assay of antimicrobial and antithrombotic properties. Results showed that crosslinkable OFP (X-OFP) and blends of OFP/PU successfully improved the mechanical strength of OFP and fewer defects of pillars were found on the textured polyphosphazene surfaces...
December 8, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29217951/five-years-malaria-trend-analysis-in-woreta-health-center-northwest-ethiopia
#14
Awoke Derbie, Megbaru Alemu
Background: An estimated 68% of the Ethiopian population, living in 75% of the landmass, is at risk of contracting malaria at any time making it the leading public health problem. The temporal analysis of malaria data could be important to evaluate the performance of malaria prevention programmes. Thus, the aim of this study was to determine the trend of malaria at Woreta Health Center (WHC) over a period of five years. Methods: We analyzed the records of 8,057 presumptive malaria patients registered in 2012 to 2016...
September 2017: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/29217380/evaluation-of-rapid-pfhrp-2-pldh-based-tests-in-diagnosing-microscopy-confirmed-falciparum-malaria-in-hodeidah-governorate-yemen
#15
Ahmed A Azazy, Ali Jamaly Alhawery, Rashad Abdul-Ghani, R A Alharbi, Shaia S R Almalki
Along with the determination of malaria infection rate among suspected patients attending hospitals in Hodeidah governorate, the present study evaluated the accuracy of Plasmodium falciparum histidine-rich protein-2 (PfHRP-2)/parasite-specific lactate dehydrogenase (pLDH)-based rapid diagnostic test (RDT) for the diagnosis of microscopy-confirmed falciparum malaria. An overall malaria infection rate of 19.3% (57/295) among suspected patients attending hospitals was microscopically confirmed. The sensitivity of thin blood films for the detection of malaria parasites was 79...
December 5, 2017: Acta Tropica
https://www.readbyqxmd.com/read/29215735/vacuolated-pas-positive-lymphocytes-as-an-hallmark-of-pompe-disease-and-other-myopathies-related-to-impaired-autophagy
#16
Angelo Pascarella, Chiara Terracciano, Olimpia Farina, Luca Lombardi, Teresa Esposito, Filomena Napolitano, Giuseppina Franzese, Giovanni Panella, Francesco Tuccillo, Giancarlo la Marca, Sergio Bernardini, Silvia Boffo, Antonio Giordano, Mariarosa Anna Beatrice Melone, Giuseppe Di Iorio, Simone Sampaolo
Autosomal recessive Pompe disease is a lysosomal disorder caused by mutations of the acid-α-glucosidase (GAA) gene. Deficiency of GAA enzyme leads to glycogen accumulation and autophagy impairment in cardiac and skeletal muscles, but also in lymphocytes. Since an effective therapy is available, a rapid, sensitive and specific test is crucial to early identify affected subjects. Number of lymphocytes containing PAS-positive vacuoles was evaluated on blood films from 72 consecutive adult patients with hyperckemia and/or muscle weakness, 13 genetically confirmed late-onset-Pompe-disease (LOPD) and 13 of their offspring...
December 7, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29212329/free-standing-hydrogel-particle-composite-membrane-with-dynamically-controlled-permeability
#17
Khulan Sergelen, Christian Petri, Ulrich Jonas, Jakub Dostalek
The preparation and investigation of a free-standing membrane made from a composite of thermoresponsive poly(N-isopropylacrylamide) (pNIPAAm) and polystyrene nanoparticles (PS NP) with temperature-controlled permeability is reported. The method exploits the light-induced crosslinking of the photo-reactive pNIPAAm-based polymer and mechanical reinforcement of the membrane structure by the polystyrene nanoparticles. About micrometer thick layers were either directly attached to a gold surface or prepared as free-standing layers spanning over arrays of microfluidic channels with a width of about hundred microns by using template stripping...
December 6, 2017: Biointerphases
https://www.readbyqxmd.com/read/29211485/surface-characterization-and-platelet-adhesion-on-thin-hydrogel-films-of-poly-vinyl-ether
#18
Nozomi Itagaki, Yukari Oda, Toyoaki Hirata, Hung Kim Nguyen, Daisuke Kawaguchi, Hisao Matsuno, Keiji Tanaka
Poly(vinyl ether), with short oxyethylene side chains which possess a simple and relatively polar structure, should be a unique candidate for a bioinert material thanks to its solubility in water. On the basis of living cationic copolymerization and subsequent ultraviolet light irradiation, thin films of poly(2-methoxyethyl vinyl ether) with different cross-linking densities were prepared on solid substrates. The films were thickened in water, and the extent was dependent on the cross-linking density. Although the surface chemistry and aggregation states were almost identical to one another, the stiffness, or the softness, of the outermost region in the film was strongly dependent on the cross-linking density...
December 6, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29202436/visual-detection-of-cyanide-ions-by-membrane-based-nanozyme-assay
#19
Chia-Wen Lien, Binesh Unnikrishnan, Scott G Harroun, Chih-Min Wang, Jia-Yaw Chang, Huan-Tsung Chang, Chih-Ching Huang
In this paper, we report a simple one-step synthesis of well-dispersed amorphous cobalt hydroxide/oxide-modified graphene oxide (CoOxH-GO) possessing peroxidase-like catalytic activity, and its application for the detection of H2O2, glucose, and CN- ions. CoOxH is formed and deposited in situ on the GO surface through the reaction between GO (size ~ 240nm) and Co2+ in basic solution at room temperature. We investigated the enzyme-mimicking activity of the CoOxH-GO nanohybrid in detail via the H2O2-mediated oxidation of Amplex Red (AR) to form fluorescent resorufin...
November 26, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29197300/gc-ms-method-for-determination-and-pharmacokinetic-study-of-seven-volatile-constituents-in-rat-plasma-after-oral-administration-of-the-essential-oil-of-rhizoma-curcumae
#20
Wenjing Li, Bo Hong, Zuojing Li, Qing Li, Kaishun Bi
Rhizoma Curcumae (RC) is perennial herbaceous plant mainly present in China, India and Malaysiabelong, which is belong to the family Zingiberaceae. The rhizomes of RC have been used as a famous traditional Chinese medicine for the treatment of syndrome of blood stasis. A selective, sensitive and accurate gas chromatography-mass spectroscopy (GC-MS) method was developed and validated in this paper for the simultaneous determination and pharmacokinetic study of α-Pinene, 1,8-Cineole, Borneol, β-Elemene, Curcumol, Germacrone, and Curdione in rat plasma...
November 28, 2017: Journal of Pharmaceutical and Biomedical Analysis
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