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dce perfusion and tumor

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https://www.readbyqxmd.com/read/28060884/contrast-enhanced-ultrasound-with-vegfr2-targeted-microbubbles-for-monitoring-regorafenib-therapy-effects-in-experimental-colorectal-adenocarcinomas-in-rats-with-dce-mri-and-immunohistochemical-validation
#1
Ralf Stefan Eschbach, Dirk-Andre Clevert, Heidrun Hirner-Eppeneder, Michael Ingrisch, Matthias Moser, Jessica Schuster, Dina Tadros, Moritz Schneider, Philipp Maximilian Kazmierczak, Maximilian Reiser, Clemens C Cyran
OBJECTIVES: To investigate contrast-enhanced ultrasound (CEUS) with VEGFR2-targeted microbubbles for monitoring therapy effects of regorafenib on experimental colon carcinomas in rats with correlation to dynamic contrast-enhanced MRI (DCE-MRI) and immunohistochemistry. MATERIALS AND METHODS: Human colorectal adenocarcinoma xenografts (HT-29) were implanted subcutaneously in n = 21 (n = 11 therapy group; n = 10 control group) female athymic nude rats (Hsd: RH-Foxn1rnu)...
2017: PloS One
https://www.readbyqxmd.com/read/28048880/su-f-r-34-quantitative-perfusion-measurement-in-rectal-cancer-using-three-different-pharmacokinetic-models-implications-for-prospective-study-design
#2
K Nie, T Mao, L Shi, N Yue, S Jabbour, S Kim, X Hu, L Qian, X Sun, T Niu
PURPOSE: To compare three different pharmacokinetic models for analysis of dynamic-contrast-enhanced (DCE)-CT data with respect to different acquisition times and location of region of interest. METHODS: Eight rectal cancer patients with pre-treatment DCE-CTs were included. The dynamic sequence started 4-10seconds(s) after the injection of contrast agent. The scan included a 110s acquisition with intervals of 40×1s+15×3s+4×6s. An experienced oncologist outlined the tumor region...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048388/su-f-r-16-delineation-of-tumor-habitats-based-on-dynamic-contrast-enhanced-mri
#3
Y Chang, G Solorzano, E Ackerstaff, R Yechieli, T Subhawong, R Stoyanova
PURPOSE: To determine an automatic procedure for determining the number and delineation of tumor habitats from Dynamic Contrast Enhanced (DCE) MRI data. METHODS: An automatic procedure for delineation of tumor habitats from DCE-MRI datasets was developed as a two-part process involving: (1) statistical testing of the principal components of the dataset to detect the number of habitats and (2) the use of this number in an unsupervised pattern recognition (PR) technique to recover the temporal pattern and location of detected habitats...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047962/tu-h-206-03-characterizing-b1-inhomogeneities-in-dce-mri
#4
H Gach, N Mason
PURPOSE: Dynamic Contrast Enhanced (DCE) MRI is a valuable technique for measuring perfusion and permeability characteristics of tumors. Exogenous contrast concentrations are calculated based on changes in T1 measured using fast 3D gradient echo (FLASH) sequences. However, the slab selective pulses used in 3D MRI may result in B1 inhomogeneities across the volume of interest that can lead to errors in T1 and thus the estimated gadolinium concentration. We compared three FLASH DCE sequences (GRE, TWIST, and VIBE) to determine their signal homogeneity across slices and the accuracy in calculating T1 using acquisitions with variable flip angles...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047002/su-f-r-25-automatic-identification-of-suspicious-recurrent-residual-disease-regions-after-prostatectomy
#5
N A Parra, M Abramowitz, A Pollack, R Stoyanova
PURPOSE: To automatically identify and outline suspicious regions of recurrent or residual disease in the prostate bed using Dynamic Contrast Enhanced-MRI (DCE-MRI) in patients after prostatectomy. METHODS: Twenty-two patients presenting for salvage radiotherapy and with identified Gross Tumor Volume (GTV) in the prostate bed were retrospectively analyzed. The MRI data consisted of Axial T2weighted-MRI (T2w) of the pelvis: resolution 1.25×1.25×2.5 mm; Field of View (FOV): 320×320 mm; slice thickness=2...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28041318/dynamic-contrast-enhanced-magnetic-resonance-imaging-of-osseous-spine-metastasis-before-and-1-hour-after-high-dose-image-guided-radiation-therapy
#6
Eric Lis, Atin Saha, Kyung K Peck, Joan Zatcky, Michael J Zelefsky, Yoshiya Yamada, Andrei I Holodny, Mark H Bilsky, Sasan Karimi
OBJECTIVE High-dose image-guided radiation therapy (HD IGRT) has been instrumental in mitigating some limitations of conventional RT. The recent emergence of dynamic contrast-enhanced (DCE) MRI to investigate tumor physiology can be used to verify the response of human tumors to HD IGRT. The purpose of this study was to evaluate the near-immediate effects of HD IGRT on spine metastases through the use of DCE MRI perfusion studies. METHODS Six patients with spine metastases from prostate, thyroid, and renal cell carcinoma who underwent HD IGRT were studied using DCE MRI prior to and 1 hour after HD IGRT...
January 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/28034567/comparison-between-perfusion-computed-tomography-and-dynamic-contrast-enhanced-magnetic-resonance-imaging-in-assessing-glioblastoma-microvasculature
#7
Zhong Zheng Jia, Wei Shi, Jin Long Shi, Dan Dan Shen, Hong Mei Gu, Xue Jun Zhou
PURPOSE: Perfusion computed tomography (PCT) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) provide independent measurements of biomarkers related to tumor perfusion. The aim of this study was to compare the two techniques in assessing glioblastoma microvasculature. MATERIALS AND METHODS: Twenty-five patients diagnosed with glioblastoma (14 males and 11 females; 51±11years old, ranging from 33 to 70 years) were includede in this prospective study...
December 19, 2016: European Journal of Radiology
https://www.readbyqxmd.com/read/28011494/mmri-at-3-0-t-as-an-evaluation-tool-of-therapeutic-response-to-neoadjuvant-crt-in-patients-with-advanced-stage-rectal-cancer
#8
Ulrike I Attenberger, Melissa M Ong, Nils Rathmann, Fabian Doyon, Peter Kienle, Ralf-Dieter Hofheinz, Lothar R Pilz, Dietmar J Dinter, Stefan O Schoenberg, Daniel Hausmann
AIM: To assess whether multiparametric MRI (mMRI) can serve as a tool for evaluating response to chemoradiation therapy (CRT) in advanced-stage rectal cancer. PATIENTS AND METHODS: Twenty-one patients underwent a mMRI protocol at 3T before and after CRT. Two experienced radiologists evaluated the MRI measurements and inter-reader correlation was assessed. Changes in functional parameters in relation to regression, as well as pT stage were analyzed. The perfusion parameters plasma flow (PF) and mean transit time (MTT) were calculated offline using the established UMM Perfusion tool...
January 2017: Anticancer Research
https://www.readbyqxmd.com/read/27992383/quantification-of-tumor-perfusion-using-dce-us-impact-of-mathematical-modeling
#9
Maxime Doury, Alexandre Dizeux, Alain de Cesare, Olivier Lucidarme, Claire Pellot-Barakat, Lori Bridal, Frédérique Frouin
Dynamic Contrast Enhanced Ultrasound has been proposed to monitor tumor therapy, in complement to volume measurements. To assess the variability of perfusion parameters in ideal conditions, four consecutive test-retest studies were acquired in a tumor model of mouse, using controlled injections. The impact of mathematical modeling on parameter variability was then investigated. Coefficients of variation (CV) of tissue blood volume (BV) and tissue blood flow (BF) based-parameters were estimated inside 32 sub-regions of the tumors, comparing the log-normal (LN) model with a one-compartment model fed by an arterial input function (AIF) and improved by the introduction of a time delay parameter...
December 19, 2016: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/27989901/flow-versus-permeability-weighting-in-estimating-the-forward-volumetric-transfer-constant-k-trans-obtained-by-dce-mri-with-contrast-agents-of-differing-molecular-sizes
#10
Cheng-He Li, Fang-Hsin Chen, Dawid Schellingerhout, Yu-Shi Lin, Ji-Hong Hong, Ho-Ling Liu
PURPOSE: To quantify the differential plasma flow- (Fp-) and permeability surface area product per unit mass of tissue- (PS-) weighting in forward volumetric transfer constant (K(trans)) estimates by using a low molecular (Gd-DTPA) versus high molecular (Gadomer) weight contrast agent in dynamic contrast enhanced (DCE) MRI. MATERIALS AND METHODS: DCE MRI was performed using a 7T animal scanner in 14 C57BL/6J mice syngeneic for TRAMP tumors, by administering Gd-DTPA (0...
October 27, 2016: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/27956462/evaluation-of-neovascularization-patterns-in-an-orthotopic-rat-glioma-model-with-dynamic-contrast-enhanced-mri
#11
Du Xuesong, Xue Wei, Liu Heng, Chen Xiao, Wang Shunan, Guo Yu, Zhang Weiguo
BACKGROUND: Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) has been proved useful in evaluating glioma angiogenesis, but the utility in evaluating neovascularization patterns has not been reported. PURPOSE: To evaluate in vivo real-time glioma neovascularization patterns by measuring glioma perfusion quantitatively using DCE-MRI. MATERIAL AND METHODS: Thirty Sprague-Dawley rats were used to establish C6 orthotopic glioma model and underwent MRI and pathology detections...
December 12, 2016: Acta Radiologica
https://www.readbyqxmd.com/read/27888709/correlations-between-dce-mri-and-histopathological-parameters-in-head-and-neck-squamous-cell-carcinoma
#12
Alexey Surov, Hans Jonas Meyer, Matthias Gawlitza, Anne-Kathrin Höhn, Andreas Boehm, Thomas Kahn, Patrick Stumpp
BACKGROUND: Dynamic contrast-enhanced magnetic resonance imaging (DCE MRI) can characterize perfusion and vascularization of tissues. DCE MRI parameters can differentiate between malignant and benign lesions and predict tumor grading. The purpose of this study was to correlate DCE MRI findings and various histopathological parameters in head and neck squamous cell carcinoma (HNSCC). PATIENTS AND METHODS: Sixteen patients with histologically proven HNSCC (11 cases primary tumors and in 5 patients with local tumor recurrence) were included in the study...
November 23, 2016: Translational Oncology
https://www.readbyqxmd.com/read/27875218/entropy-of-ultrasound-contrast-agent-velocity-fields-for-angiogenesis-imaging-in-prostate-cancer
#13
Ruud van Sloun, Libertario Demi, Arnoud Postema, Jean de la Rosette, Hessel Wijkstra, Massimo Mischi
Prostate cancer care can benefit from accurate and cost-efficient imaging modalities that are able to reveal prognostic indicators for cancer. Angiogenesis is known to play a central role in the growth of tumors towards a metastatic or a lethal phenotype.With the aim of localizing angiogenic activity in a noninvasive manner, Dynamic Contrast Enhanced Ultrasound (DCEUS) has been widely used. Usually, the passage of ultrasound contrast agents thought the organ of interest is analyzed for the assessment of tissue perfusion...
November 16, 2016: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/27806585/time-resolved-angiography-with-stochastic-trajectories-for-dynamic-contrast-enhanced-mri-in-head-and-neck-cancer-are-pharmacokinetic-parameters-affected
#14
Rafal Panek, Maria A Schmidt, Marco Borri, Dow-Mu Koh, Angela Riddell, Liam Welsh, Alex Dunlop, Ceri Powell, Shreerang A Bhide, Christopher M Nutting, Kevin J Harrington, Kate L Newbold, Martin O Leach
PURPOSE: To investigate the effects of different time-resolved angiography with stochastic trajectories (TWIST) k-space undersampling schemes on calculated pharmacokinetic dynamic contrast-enhanced (DCE) vascular parameters. METHODS: A digital perfusion phantom was employed to simulate effects of TWIST on characteristics of signal changes in DCE. Furthermore, DCE-MRI was acquired without undersampling in a group of patients with head and neck squamous cell carcinoma and used to simulate a range of TWIST schemes...
November 2016: Medical Physics
https://www.readbyqxmd.com/read/27797110/increased-robustness-in-reference-region-model-analysis-of-dce-mri-using-two-step-constrained-approaches
#15
Zaki Ahmed, Ives R Levesque
PURPOSE: Reference region models (RRMs) can quantify tumor perfusion in dynamic contrast-enhanced MRI without an arterial input function. Inspection of the RRM reveals that one of the free parameters in the fit is uniquely linked to the reference region and is common to all voxels. A two-step approach is proposed that takes this constraint into account. METHODS: Three constrained RRM (CRRM) approaches were devised and evaluated. Simulations were performed to compare their accuracy and precision over a range of noise and temporal resolutions...
October 31, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27796446/prognostic-value-of-preoperative-dynamic-contrast-enhanced-mri-perfusion-parameters-for-high-grade-glioma-patients
#16
Agne Ulyte, Vasileios K Katsaros, Evangelia Liouta, Georgios Stranjalis, Christos Boskos, Nickolas Papanikolaou, Jurgita Usinskiene, Sotirios Bisdas
INTRODUCTION: The prognostic value of the dynamic contrast-enhanced (DCE) MRI perfusion and its histogram analysis-derived metrics is not well established for high-grade glioma (HGG) patients. The aim of this prospective study was to investigate DCE perfusion transfer coefficient (K(trans)), vascular plasma volume fraction (vp), extracellular volume fraction (ve), reverse transfer constant (kep), and initial area under gadolinium concentration time curve (IAUGC) as predictors of progression-free (PFS) and overall survival (OS) in HGG patients...
December 2016: Neuroradiology
https://www.readbyqxmd.com/read/27780936/low-dose-angiostatic-treatment-counteracts-radiotherapy-induced-tumor-perfusion-and-enhances-the-anti-tumor-effect
#17
Esther A Kleibeuker, Emmanouil Fokas, Philip D Allen, Veerle Kersemans, Arjan W Griffioen, John Beech, Jaehong H Im, Sean C Smart, Kitty C Castricum, Jaap van den Berg, Iris A Schulkens, Sally A Hill, Adrian L Harris, Ben J Slotman, Henk M Verheul, Ruth J Muschel, Victor L Thijssen
The extent of tumor oxygenation is an important factor contributing to the efficacy of radiation therapy (RTx). Interestingly, several preclinical studies have shown benefit of combining RTx with drugs that inhibit tumor blood vessel growth, i.e. angiostatic therapy. Recent findings show that proper scheduling of both treatment modalities allows dose reduction of angiostatic drugs without affecting therapeutic efficacy. We found that whilst low dose sunitinib (20 mg/kg/day) did not affect the growth of xenograft HT29 colon carcinoma tumors in nude mice, the combination with either single dose RTx (1x 5Gy) or fractionated RTx (5x 2Gy/week, up to 3 weeks) substantially hampered tumor growth compared to either RTx treatment alone...
October 21, 2016: Oncotarget
https://www.readbyqxmd.com/read/27776667/dynamic-contrast-enhanced-case-control-analysis-in-3t-mri-of-prostate-cancer-can-help-to-characterize-tumor-aggressiveness
#18
COMPARATIVE STUDY
Roberto Sanz-Requena, Luis Martí-Bonmatí, Rosario Pérez-Martínez, Gracián García-Martí
PURPOSE: The aim of this work is to establish normality and tumor tissue ranges for perfusion parameters from dynamic contrast-enhanced (DCE) MR of the peripheral prostate at 3T and to compare the diagnostic performance of quantitative and semi-quantitative parameters. MATERIALS AND METHODS: Thirty-six patients with prostate carcinomas (18 Gleason-6, 15 Gleason-7, and 3 Gleason-8) and 33 healthy subjects were included. Image analysis workflow comprised four steps: manual segmentation of whole prostate and lesions, series registration, voxelwise T1 mapping and calculation of pharmacokinetic and semi-quantitative parameters...
November 2016: European Journal of Radiology
https://www.readbyqxmd.com/read/27762331/dce-mri-perfusion-and-permeability-parameters-as-predictors-of-tumor-response-to-ccrt-in-patients-with-locally-advanced-nsclc
#19
Xiuli Tao, Lvhua Wang, Zhouguang Hui, Li Liu, Feng Ye, Ying Song, Yu Tang, Yu Men, Tryphon Lambrou, Zihua Su, Xiao Xu, Han Ouyang, Ning Wu
In this prospective study, 36 patients with stage III non-small cell lung cancers (NSCLC), who underwent dynamic contrast-enhanced MRI (DCE-MRI) before concurrent chemo-radiotherapy (CCRT) were enrolled. Pharmacokinetic analysis was carried out after non-rigid motion registration. The perfusion parameters [including Blood Flow (BF), Blood Volume (BV), Mean Transit Time (MTT)] and permeability parameters [including endothelial transfer constant (K(trans)), reflux rate (Kep), fractional extravascular extracellular space volume (Ve), fractional plasma volume (Vp)] were calculated, and their relationship with tumor regression was evaluated...
October 20, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27742432/correlation-study-between-intravoxel-incoherent-motion-mri-and-dynamic-contrast-enhanced-mri-in-head-and-neck-squamous-cell-carcinoma-evaluation-in-primary-tumors-and-metastatic-nodes
#20
Simona Marzi, Francesca Piludu, Chiara Forina, Giuseppe Sanguineti, Renato Covello, Giuseppe Spriano, Antonello Vidiri
OBJECTIVE: To correlate intravoxel incoherent motion (IVIM) imaging and dynamic contrast-enhanced (DCE) MRI in head and neck squamous cell carcinoma (HNSCC). METHODS: Forty untreated patients with HNSCC were included retrospectively in the study. Perfusion fraction f, diffusion coefficient D and perfusion-related diffusion coefficient D* were extracted by bi-exponential fitting of IVIM data. Semi-quantitative DCE-MRI parameters, including positive enhancement integral (PEI) and maximum slope of increase (MSI), were calculated...
October 11, 2016: Magnetic Resonance Imaging
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