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JOURNAL ARTICLE
B Liu, H Gao, F Zhou, W Zhao, Y Yang
AIM: To investigate whether dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) has the potential to non-invasively detect microenvironmental condition by quantitatively measuring blood perfusion, vessel wall permeability, and vascularity, and to elucidate the possible correlations between DCE-MRI quantitative parameters and the expression level of hypoxia, vascularity, and cell proliferation related molecular biomarkers. MATERIALS AND METHODS: In this prospective single center clinical study, 58 patients diagnosed with cervical cancer underwent DCE-MRI before anticancer treatment were enrolled...
March 15, 2024: Clinical Radiology
#2
JOURNAL ARTICLE
Devan Diwanji, Natsuko Onishi, Deep K Hathi, Courtney Lawhn-Heath, John Kornak, Wen Li, Ruby Guo, Julissa Molina-Vega, Youngho Seo, Robert R Flavell, Diane Heditsian, Susie Brain, Laura J Esserman, Bonnie N Joe, Nola M Hylton, Ella F Jones, Kimberly M Ray
Purpose To compare quantitative measures of tumor metabolism and perfusion using fluorine 18 (18 F) fluorodeoxyglucose (FDG) dedicated breast PET (dbPET) and breast dynamic contrast-enhanced (DCE) MRI during early treatment with neoadjuvant chemotherapy (NAC). Materials and Methods Prospectively collected DCE MRI and 18 F-FDG dbPET examinations were analyzed at baseline (T0) and after 3 weeks (T1) of NAC in 20 participants with 22 invasive breast cancers. FDG dbPET-derived standardized uptake value (SUV), metabolic tumor volume, and total lesion glycolysis (TLG) and MRI-derived percent enhancement (PE), signal enhancement ratio (SER), and functional tumor volume (FTV) were calculated at both time points...
March 2024: Radiology. Imaging cancer
#3
JOURNAL ARTICLE
Xiu-Yun Lu, Jun Jiang, Sheng Chen, Yi-Jie Qiu, Ying Wang, Juan Cheng, Xin-Liang Xu, Yi Dong, Wen-Ping Wang
OBJECTIVE: To evaluate the value of dynamic contrast-enhanced ultrasound (DCE-US) analysis in early prediction of tumor response to systemic treatment in patients with intrahepatic cholangiocarcinoma (ICC). PATIENTS & METHODS: In this retrospective study, patients diagnosed with ICC by core needle biopsy and histopathological results were included. All patients were diagnosed as advanced stages (stage III/IV) by the 8th edition of the American Joint Committee on Cancer (AJCC)/International Union Against Cancer (UICC) TNM staging system...
March 23, 2024: European Journal of Radiology
#4
JOURNAL ARTICLE
Yu-Ning Pan, Meng-Yin Gu, Quan-Liang Mao, Yu-Guo Wei, Lin Zhang, Guang-Yu Tang
PURPOSE: Non-invasive methods for predicting pathological complete response (pCR) after neoadjuvant chemoradiotherapy (nCRT) can provide distinct leverage in the management of patients with locally advanced rectal cancer (LARC). This study aimed to investigate whether including the golden-angle radial sparse parallel (GRASP) dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) perfusion parameter (Ktrans ), in addition to tumor regression grading (TRG) and apparent diffusion coefficient (ADC) values, can improve the predictive ability for pCR...
March 26, 2024: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
#5
JOURNAL ARTICLE
Zhiqiang Li, Dinghui Wang, Melvyn B Ooi, Poonam Choudhary, Sudarshan Ragunathan, John P Karis, James G Pipe, C Chad Quarles, Ashley M Stokes
PURPOSE: Perfusion MRI reveals important tumor physiological and pathophysiologic information, making it a critical component in managing brain tumor patients. This study aimed to develop a dual-echo 3D spiral technique with a single-bolus scheme to simultaneously acquire both dynamic susceptibility contrast (DSC) and dynamic contrast-enhanced (DCE) data and overcome the limitations of current EPI-based techniques. METHODS: A 3D spiral-based technique with dual-echo acquisition was implemented and optimized on a 3T MRI scanner with a spiral staircase trajectory and through-plane SENSE acceleration for improved speed and image quality, in-plane variable-density undersampling combined with a sliding-window acquisition and reconstruction approach for increased speed, and an advanced iterative deblurring algorithm...
March 12, 2024: Magnetic Resonance in Medicine
#6
JOURNAL ARTICLE
Mingyue Zou, Bingqian Zhang, Lei Shi, Haijia Mao, Yanan Huang, Zhenhua Zhao
To explore the relationship between quantitative perfusion histogram parameters of dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) with the expression of tumor tissue epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF) and EGFR gene mutations in non-small cell lung cancer (NSCLC). A total of 44 consecutive patients with known NSCLC were recruited from March 2018 to August 2021. Histogram parameters (mean, uniformity, skewness, energy, kurtosis, entropy, percentile) of each (Ktrans , Kep , Ve , Vp , Fp ) were obtained by Omni Kinetics software...
February 23, 2024: Scientific Reports
#7
JOURNAL ARTICLE
Hui Ma, Shanmei Zeng, Dingxiang Xie, Wenting Zeng, Yingqian Huang, Liwei Mazu, Nengjin Zhu, Zhiyun Yang, Jianping Chu, Jing Zhao
BACKGROUND: The aim of the study was to investigate the diagnostic value of imaging necrosis (Imnecrosis ) in grading, predict the genotype and prognosis of gliomas, and further assess tumor necrosis by dynamic contrast-enhanced MR perfusion imaging (DCE-MRI). PATIENTS AND METHODS: We retrospectively included 150 patients (104 males, mean age: 46 years old) pathologically proved as adult diffuse gliomas and all diagnosis was based on the 2021 WHO central nervous system (CNS) classification...
March 1, 2024: Radiology and Oncology
#8
REVIEW
Lucia Cerrito, Maria Elena Ainora, Giuseppe Cuccia, Linda Galasso, Irene Mignini, Giorgio Esposto, Matteo Garcovich, Laura Riccardi, Antonio Gasbarrini, Maria Assunta Zocco
Hepatocellular carcinoma (HCC) is the most frequent primary liver cancer and the sixth most common malignant tumor in the world, with an incidence of 2-8% per year in patients with hepatic cirrhosis or chronic hepatitis. Despite surveillance schedules, it is sometimes diagnosed at an advanced stage, requiring complex therapeutic efforts with both locoregional and systemic treatments. Traditional radiological tools (computed tomography and magnetic resonance) are used for the post-treatment follow-up of HCC...
January 27, 2024: Cancers
#9
JOURNAL ARTICLE
Vivien Richter, Thomas Nägele, Günther Erb, Uwe Klose, Ulrike Ernemann, Till-Karsten Hauser
BACKGROUND AND PURPOSE: To evaluate the feasibility of a multimodal approach involving dynamic contrast-enhanced (DCE) perfusion imaging and diffusion kurtosis imaging (DKI) in the preoperative imaging of brain tumors in a multicenter setting, and to evaluate the effect on diagnostic confidence and accuracy for tumor grade and type prediction. MATERIALS AND METHODS: One hundred and thirty-three patients with brain tumors were imaged in six hospitals with a standardized multimodal protocol...
January 10, 2024: European Journal of Radiology
#10
JOURNAL ARTICLE
Thibaut Jeganathan, Emile Salgues, Ulrike Schick, Valentin Tissot, Georges Fournier, Antoine Valéri, Truong-An Nguyen, Vincent Bourbonne
INTRODUCTION: External radiotherapy is a major treatment for localized prostate cancer (PCa). Dose escalation to the whole prostate gland increases biochemical relapse-free survival but also acute and late toxicities. Dose escalation to the dominant index lesion (DIL) only is of growing interest. It requires a robust delineation of the DIL. In this context, we aimed to evaluate the inter-observer variability of DIL delineation. MATERIAL AND METHODS: Two junior radiologists and a senior radiation oncologist delineated DILs on 64 mpMRIs of patients with histologically confirmed PCa...
December 14, 2023: Biomedicines
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JOURNAL ARTICLE
Eve S Shalom, Harrison Kim, Rianne A van der Heijden, Zaki Ahmed, Reyna Patel, David A Hormuth, Julie C DiCarlo, Thomas E Yankeelov, Nicholas J Sisco, Richard D Dortch, Ashley M Stokes, Marianna Inglese, Matthew Grech-Sollars, Nicola Toschi, Prativa Sahoo, Anup Singh, Sanjay K Verma, Divya K Rathore, Anum S Kazerouni, Savannah C Partridge, Eve LoCastro, Ramesh Paudyal, Ivan A Wolansky, Amita Shukla-Dave, Pepijn Schouten, Oliver J Gurney-Champion, Radovan Jiřík, Ondřej Macíček, Michal Bartoš, Jiří Vitouš, Ayesha Bharadwaj Das, S Gene Kim, Louisa Bokacheva, Artem Mikheev, Henry Rusinek, Michael Berks, Penny L Hubbard Cristinacce, Ross A Little, Susan Cheung, James P B O'Connor, Geoff J M Parker, Brendan Moloney, Peter S LaViolette, Samuel Bobholz, Savannah Duenweg, John Virostko, Hendrik O Laue, Kyunghyun Sung, Ali Nabavizadeh, Hamidreza Saligheh Rad, Leland S Hu, Steven Sourbron, Laura C Bell, Anahita Fathi Kazerooni
PURPOSE: <mml:math xmlns:mml="https://www.w3.org/1998/Math/MathML"><mml:semantics><mml:mrow><mml:msup><mml:mi>K</mml:mi> <mml:mtext>trans</mml:mtext></mml:msup> </mml:mrow> <mml:annotation>$$ {K}^{\mathrm{trans}} $$</mml:annotation></mml:semantics> </mml:math> has often been proposed as a quantitative imaging biomarker for diagnosis, prognosis, and treatment response assessment for various tumors. None of the many software tools for <mml:math xmlns:mml="https://www...
December 19, 2023: Magnetic Resonance in Medicine
#12
JOURNAL ARTICLE
Albert E Kim, Kevin W Lou, Anita Giobbie-Hurder, Ken Chang, Mishka Gidwani, Katharina Hoebel, Jay B Patel, Mason C Cleveland, Praveer Singh, Christopher P Bridge, Syed Rakin Ahmed, Benjamin A Bearce, William Liu, Elies Fuster-Garcia, Eudocia Q Lee, Nancy U Lin, Beth Overmoyer, Patrick Y Wen, Lakshmi Nayak, Justine V Cohen, Jorg Dietrich, April Eichler, Rebecca Heist, Ian Krop, Donald Lawrence, Jennifer Ligibel, Sara Tolaney, Erica Mayer, Eric Winer, Carmen M Perrino, Elizabeth J Summers, Maura Mahar, Kevin Oh, Helen A Shih, Daniel P Cahill, Bruce R Rosen, Yi-Fen Yen, Jayashree Kalpathy-Cramer, Maria Martinez-Lage, Ryan J Sullivan, Priscilla K Brastianos, Kyrre E Emblem, Elizabeth R Gerstner
BACKGROUND: We recently conducted a phase 2 trial (NCT028865685) evaluating intracranial efficacy of pembrolizumab for brain metastases (BM) of diverse histologies. Our study met its primary efficacy endpoint and illustrates that pembrolizumab exerts promising activity in a select group of patients with BM. Given the importance of aberrant vasculature in mediating immunosuppression, we explored the relationship between checkpoint inhibitor (ICI) efficacy and vascular architecture in the hopes of identifying potential mechanisms of intracranial ICI response or resistance for BM...
December 9, 2023: Neuro-oncology
#13
REVIEW
Qing Yuan, Debora Z Recchimuzzi, Daniel N Costa
Magnetic resonance (MR) perfusion imaging, both with and without exogenous contrast agents, has the potential to assess tissue perfusion and vascularity in prostate cancer. Dynamic contrast-enhanced (DCE) MRI is an important element of the clinical non-invasive multiparametric MRI, which can be used to differentiate benign from malignant lesions, to stage tumors, and to monitor response to therapy. The arterial spin labeled (ASL) and intravoxel incoherent motion (IVIM) diffusion-weighted MRI have the advantage of quantitative perfusion measurements without the concerns of gadolinium-based contrast agent safety and retention issues...
February 2024: Magnetic Resonance Imaging Clinics of North America
#14
REVIEW
Durga Udayakumar, Ananth J Madhuranthakam, Başak E Doğan
Breast cancer is the most frequently diagnosed cancer among women worldwide, carrying a significant socioeconomic burden. Breast cancer is a heterogeneous disease with 4 major subtypes identified. Each subtype has unique prognostic factors, risks, treatment responses, and survival rates. Advances in targeted therapies have considerably improved the 5-year survival rates for primary breast cancer patients largely due to widespread screening programs that enable early detection and timely treatment. Imaging techniques are indispensable in diagnosing and managing breast cancer...
February 2024: Magnetic Resonance Imaging Clinics of North America
#15
JOURNAL ARTICLE
Anum S Kazerouni, Lanell M Peterson, Isaac Jenkins, Alena Novakova-Jiresova, Hannah M Linden, Julie R Gralow, David M Hockenbery, David A Mankoff, Peggy L Porter, Savannah C Partridge, Jennifer M Specht
PURPOSE: To investigate combined MRI and 18 F-FDG PET for assessing breast tumor metabolism/perfusion mismatch and predicting pathological response and recurrence-free survival (RFS) in women treated for breast cancer. METHODS: Patients undergoing neoadjuvant chemotherapy (NAC) for locally-advanced breast cancer were imaged at three timepoints (pre, mid, and post-NAC), prior to surgery. Imaging included diffusion-weighted and dynamic contrast-enhanced (DCE-) MRI and quantitative 18 F-FDG PET...
November 9, 2023: Breast Cancer Research: BCR
#16
JOURNAL ARTICLE
Michael Iv, Lewis Naya, Sajal Sanan, Samuel L Van Buskirk, Seema Nagpal, Reena P Thomas, Lawrence D Recht, Chirag B Patel
BACKGROUND AND OBJECTIVE: 200 kHz tumor treating fields (TTFields) is clinically approved for newly-diagnosed glioblastoma (nGBM). Because its effects on conventional surveillance MRI brain scans are equivocal, we investigated its effects on perfusion MRI (pMRI) brain scans. METHODS: Each patient underwent institutional standard pMRI: dynamic contrast-enhanced (DCE) and dynamic susceptibility contrast (DSC) pMRI at three time points: baseline, 2-, and 6-months on-adjuvant therapy...
November 6, 2023: Neuroradiology Journal
#17
REVIEW
Hedda J van der Hulst, Robin W Jansen, Conchita Vens, Paula Bos, Winnie Schats, Marcus C de Jong, Roland M Martens, Zuhir Bodalal, Regina G H Beets-Tan, Michiel W M van den Brekel, Pim de Graaf, Jonas A Castelijns
Magnetic resonance imaging (MRI) is an indispensable, routine technique that provides morphological and functional imaging sequences. MRI can potentially capture tumor biology and allow for longitudinal evaluation of head and neck squamous cell carcinoma (HNSCC). This systematic review and meta-analysis evaluates the ability of MRI to predict tumor biology in primary HNSCC. Studies were screened, selected, and assessed for quality using appropriate tools according to the PRISMA criteria. Fifty-eight articles were analyzed, examining the relationship between (functional) MRI parameters and biological features and genetics...
October 20, 2023: Cancers
#18
JOURNAL ARTICLE
Francesco Sanvito, Catalina Raymond, Nicholas S Cho, Jingwen Yao, Akifumi Hagiwara, Joey Orpilla, Linda M Liau, Richard G Everson, Phioanh L Nghiemphu, Albert Lai, Robert Prins, Noriko Salamon, Timothy F Cloughesy, Benjamin M Ellingson
OBJECTIVE: To determine the feasibility and biologic correlations of dynamic susceptibility contrast (DSC), dynamic contrast enhanced (DCE), and quantitative maps derived from contrast leakage effects obtained simultaneously in gliomas using dynamic spin-and-gradient-echo echoplanar imaging (dynamic SAGE-EPI) during a single contrast injection. MATERIALS AND METHODS: Thirty-eight patients with enhancing brain gliomas were prospectively imaged with dynamic SAGE-EPI, which was processed to compute traditional DSC metrics (normalized relative cerebral blood flow [nrCBV], percentage of signal recovery [PSR]), DCE metrics (volume transfer constant [Ktrans ], extravascular compartment [ve ]), and leakage effect metrics: ΔR2,ss * (reflecting T2 *-leakage effects), ΔR1,ss (reflecting T1 -leakage effects), and the transverse relaxivity at tracer equilibrium (TRATE, reflecting the balance between ΔR2,ss * and ΔR1,ss )...
October 26, 2023: European Radiology
#19
JOURNAL ARTICLE
Edengenet Mashilla Dejene, Winfried Brenner, Marcus R Makowski, Christoph Kolbitsch
OBJECTIVE: Physiological parameter estimation is affected by intrinsic ambiguity in the data such as noise and model inaccuracies. The aim of this work is to provide a deep learning framework for accurate parameter and uncertainty estimates for DCE-MRI in the liver. APPROACH: Concentration time curves are simulated to train a Bayesian neural network (BNN). Training of the BNN involves minimization of a loss function that jointly minimizes the aleatoric and epistemic uncertainties...
October 11, 2023: Physics in Medicine and Biology
#20
JOURNAL ARTICLE
L McCullum, G Jacobson, N H Tahon, P R Bhosale, C M Taniguchi, J Ma, E P Tamm, E J Koay, J Niedzielski
PURPOSE/OBJECTIVE(S): Intravoxel Incoherent Motion (IVIM) Magnetic Resonance Imaging (MRI) is an emergent technique used to quantify diffusion and perfusion without the use of contrast agent. Our objective was to evaluate changes in IVIM parameters pre- and post-Radiation Therapy (RT) / chemotherapy in Pancreatic Ductal Adenocarcinoma (PDAC) patients to correlate these parameters and their changes with tumor radiation response. MATERIALS/METHODS: Pre- and post-treatment IVIM scans were acquired from 12 patients (median age: 70 [41-83]) with PDAC treated with RT (median: 98 [39-116] Gy BED) and chemotherapy...
October 1, 2023: International Journal of Radiation Oncology, Biology, Physics
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