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https://www.readbyqxmd.com/read/29771954/preoperative-prediction-of-microvascular-invasion-of-hepatocellular-carcinoma-with-ivim-diffusion-weighted-mr-imaging-and-gd-eob-dtpa-enhanced-mr-imaging
#1
Wei Zhao, Wenguang Liu, Huaping Liu, Xiaoping Yi, Jiale Hou, Yigang Pei, Hui Liu, Deyun Feng, Liyu Liu, Wenzheng Li
Microvascular invasion (MVI) is regarded as one of the independent risk factors for recurrence and poor prognosis of hepatocellular carcinoma (HCC). The presence of MVI in HCCs was evaluated on the basis of pathological reports of surgical specimens and was defined as tumor within a vascular space lined by endothelium that was visible only on microscopy. The aim of the study was to investigate the usefulness of intravoxel incoherent motion (IVIM) diffusion weighted (DW) magnetic resonance (MR) imaging in predicting MVI of HCC...
2018: PloS One
https://www.readbyqxmd.com/read/29769199/metabolic-imaging-of-the-human-brain-with-hyperpolarized-13c-pyruvate-demonstrates-13c-lactate-production-in-brain-tumor-patients
#2
Vesselin Z Miloushev, Kristin L Granlund, Rostislav Boltyanskiy, Serge K Lyashchenko, Lisa M DeAngelis, Ingo K Mellinghoff, Cameron W Brennan, Viviane Tabar, T Jonathan Yang, Andrei I Holodny, Ramon E Sosa, YanWei W Guo, Albert P Chen, James Tropp, Fraser Robb, Kayvan R Keshari
Hyperpolarized (HP) magnetic resonance imaging using [1-13C] pyruvate is a novel method that can characterize energy metabolism in the human brain and brain tumors. Here we present the first dynamically acquired human brain HP 13C metabolic spectra and spatial metabolite maps in cases of both untreated and recurrent tumors. In vivo production of HP lactate from HP pyruvate by tumors was indicative of altered cancer metabolism, while production of HP lactate in the entire brain was likely due to baseline metabolism...
May 16, 2018: Cancer Research
https://www.readbyqxmd.com/read/29765520/histogram-analysis-parameters-of-dynamic-contrast-enhanced-magnetic-resonance-imaging-can-predict-histopathological-findings-including-proliferation-potential-cellularity-and-nucleic-areas-in-head-and-neck-squamous-cell-carcinoma
#3
Alexey Surov, Hans Jonas Meyer, Leonard Leifels, Anne-Kathrin Höhn, Cindy Richter, Karsten Winter
Our purpose was to analyze possible associations between histogram analysis parameters of dynamic contrast-enhanced magnetic resonance imaging DCE MRI and histopathological findings like proliferation index, cell count and nucleic areas in head and neck squamous cell carcinoma (HNSCC). 30 patients (mean age 57.0 years) with primary HNSCC were included in the study. In every case, histogram analysis parameters of Ktrans , Ve , and Kep were estimated using a mathlab based software. Tumor proliferation index, cell count, and nucleic areas were estimated on Ki 67 antigen stained specimens...
April 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29731779/early-changes-in-tumor-perfusion-from-t1-weighted-dynamic-contrast-enhanced-mri-following-neural-stem-cell-mediated-therapy-of-recurrent-high-grade-glioma-correlate-with-overall-survival
#4
Prativa Sahoo, Paul Frankel, Julie Ressler, Margarita Gutova, Alexander J Annala, Behnam Badie, Jana Portnow, Karen S Aboody, Massimo D'Apuzzo, Russell C Rockne
Background: The aim of this study was to correlate T1-weighted dynamic contrast-enhanced MRI- (DCE-MRI-) derived perfusion parameters with overall survival of recurrent high-grade glioma patients who received neural stem cell- (NSC-) mediated enzyme/prodrug gene therapy. Methods: A total of 12 patients were included in this retrospective study. All patients were enrolled in a first-in-human study (NCT01172964) of NSC-mediated therapy for recurrent high-grade glioma...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29717790/use-of-diffusion-kurtosis-imaging-and-quantitative-dynamic-contrast-enhanced-mri-for-the-differentiation-of-breast-tumors
#5
Ting Li, Tao Yu, Lyu Li, Lunbo Lu, Yaoyao Zhuo, Jingge Lian, Yun Xiong, Dexing Kong, Kangan Li
BACKGROUND: Breast MRI is a sensitive imaging technique to assess breast cancer but its effectiveness still remains to be improved. PURPOSE: To evaluate the diagnostic performance of diffusion-weighted imaging (DWI), diffusion kurtosis imaging (DKI), and quantitative dynamic contrast-enhanced (DCE)-MRI in differentiating malignant from benign breast lesions independently or jointly and to explore whether correlations exist among these parameters. STUDY TYPE: Retrospective...
May 2, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29697054/incorporating-drug-delivery-into-an-imaging-driven-mechanics-coupled-reaction-diffusion-model-for-predicting-the-response-of-breast-cancer-to-neoadjuvant-chemotherapy-theory-and-preliminary-clinical-results
#6
Angela M Jarrett, David A Hormuth Ii, Stephanie L Barnes, Xinzeng Feng, Wei Huang, Thomas E Yankeelov
Clinical methods for assessing tumor response to therapy are largely rudimentary, monitoring only temporal changes in tumor size. Our goal is to predict the response of breast tumors to therapy using a mathematical model that utilizes magnetic resonance imaging (MRI) data obtained non-invasively from individual patients. We extended a previously established, mechanically coupled, reaction-diffusion model for predicting tumor response initialized with patient-specific diffusion weighted MRI (DW-MRI) data by including the effects of chemotherapy drug delivery, which is estimated using dynamic contrast-enhanced (DCE-) MRI data...
April 26, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29680254/correlation-between-tumor-metabolism-and-semiquantitative-perfusion-magnetic-resonance-imaging-metrics-in-non-small-cell-lung-cancer
#7
Sang Ho Lee, Andreas Rimner, Emily Gelb, Joseph O Deasy, Margie A Hunt, John L Humm, Neelam Tyagi
PURPOSE: To correlate semiquantitative parameters derived from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and 18 F-fluorodeoxyglucose positron emission tomography (18 F-FDG-PET) for non-small cell lung cancer (NSCLC). METHODS AND MATERIALS: Twenty-four NSCLC patients who underwent pretreatment 18 F-FDG-PET and DCE-MRI were analyzed. The maximum standardized uptake value (SUVmax) was measured from 18F-FDG-PET. Dynamic contrast-enhanced MRI was obtained on a 3T MRI scanner using 4-dimensional T1-weighted high-resolution imaging with a volume excitation sequence...
March 2, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29552285/mr-imaging-biomarkers-evaluating-vascular-normalization-window-after-anti-vessel-treatment
#8
Jun Yang, Chengde Liao, Yifan Liu, Guangjun Yang, Tengfei Ke, Yingying Ding, Qinqing Li
The beginning and the end of the vascular normalization window are not clear in response to anti-angiogenic therapies. We used dynamic contrast-enhanced MRI (DCE-MRI) and intravoxel incoherent motion MRI (IVIM-MRI) to noninvasively evaluate the vascular normalization window. MRI was performed five times: before treatment and on the second, fourth, sixth and eighth days of treatment. Quantitative perfusion parameters were calculated at each time point, including the volume transfer coefficient (Ktrans), reverse transfer constant (Kep), pseudodiffusion coefficient (D* ) and perfusion fraction (f)...
February 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29508241/multiparametric-mr-imaging-detects-therapy-efficacy-of-radioactive-seeds-brachytherapy-in-pancreatic-ductal-adenocarcinoma-xenografts
#9
Yu Liu, Yuanjun Wang, Weiqing Tang, Mengda Jiang, Kaicheng Li, Xiaofeng Tao
OBJECTIVE: To investigate the therapeutic efficacy of Iodine-125 (125 I) seeds brachytherapy to pancreatic ductal adenocarcinoma (PDAC) xenografts via multiparametric magnetic resonance imaging (MRI) analysis. MATERIALS AND METHODS: Twenty mice were implanted subcutaneously with SW-1990 PDAC xenografts. The tumor-bearing mice were randomly divided into 125 I seeds group (n = 10) and blank control group (n = 10). Treatment response was monitored by diffusion-weighted magnetic resonance imaging (DW-MRI) and dynamic contrast-enhanced MRI (DCE-MRI) obtained 1 day before, 14 and 60 days after treatment...
March 5, 2018: La Radiologia Medica
https://www.readbyqxmd.com/read/29491096/associations-between-histogram-analysis-dce-mri-parameters-and-complex-18-f-fdg-pet-values-in-head-and-neck-squamous-cell-carcinoma
#10
Alexey Surov, Leonard Leifels, Hans Jonas Meyer, Karsten Winter, Osama Sabri, Sandra Purz
AIM: To analyze associations between parameters of positron-emission tomography (PET) and histogram analysis values of dynamic contrast-enhanced (DCE) imaging in patients with head and neck squamous cell carcinoma (HNSCC). PATIENTS AND METHODS: Overall, 28 patients with primary HNSCC of different localizations were involved. 18 F-FDG-PET/CT and DCE MR imaging were performed for all patients. Histogram analysis parameters of DCE MRI were calculated. Spearman's correlation coefficient was used to analyze the associations between investigated parameters...
March 2018: Anticancer Research
https://www.readbyqxmd.com/read/29476781/repeatability-and-correlations-of-dynamic-contrast-enhanced-and-t2-mri-in-patients-with-advanced-pancreatic-ductal-adenocarcinoma
#11
Remy Klaassen, Oliver J Gurney-Champion, Johanna W Wilmink, Marc G Besselink, Marc R W Engelbrecht, Jaap Stoker, Aart J Nederveen, Hanneke W M van Laarhoven
BACKGROUND: In current oncological practice of pancreatic ductal adenocarcinoma (PDAC), there is a great demand for response predictors and markers for early treatment evaluation. In this study, we investigated the repeatability and the interaction of dynamic contrast enhanced (DCE) and T2* MRI in patients with advanced PDAC to enable for such evaluation using these techniques. MATERIALS & METHODS: 15 PDAC patients underwent two DCE, T2* and anatomical 3 T MRI sessions before start of treatment...
February 21, 2018: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29473980/low-dose-t1w-dce-mri-for-early-time-points-perfusion-measurement-in-patients-with-intracranial-tumors-a-pilot-study-applying-the-microsphere-model-to-measure-absolute-cerebral-blood-flow
#12
Ka-Loh Li, Daniel Lewis, Alan Jackson, Sha Zhao, Xiaoping Zhu
BACKGROUND: Previous studies have measured cerebral blood flow (CBF) with DSC-MRI using an "early time points" (ET) method based on microsphere theory. PURPOSE: To develop and assess a new ET method for absolute CBF estimation using low-dose high-temporal (LDHT) T1W-DCE-MRI. STUDY TYPE: Retrospective cohort study. SUBJECTS: Seven patients with sporadic vestibular schwannoma (VS) who underwent test-retest imaging; one patient with glioblastoma multiforme (GBM) imaged pretreatment; and 12 neurofibromatosis type 2 (NF2) patients undergoing bevacizumab treatment, imaged pre- and 90 days posttreatment...
February 23, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29441225/assessment-of-the-agreement-between-cerebral-hemodynamic-indices-quantified-using-dynamic-susceptibility-contrast-and-dynamic-contrast-enhanced-perfusion-magnetic-resonance-imagings
#13
Seyed Salman Zakariaee, Mohammad Ali Oghabian, Kavous Firouznia, Guive Sharifi, Farshid Arbabi, Farhad Samiei
Background: Brain tumor is one of the most common tumors. A successful treatment might be achieved with an early identification. Pathological investigation as the gold standard method for tumor identification has some limitations. Noninvasive assessment of tumor specifications may be possible using perfusion-weighted magnetic resonance imaging (MRI). Cerebral blood volume (CBV) and cerebral blood flow (CBF) could be calculated based on dynamic contrast-enhanced MRI (DCE-MRI) in addition to dynamic susceptibility contrast MRI (DSC-MRI) modality...
2018: Journal of Clinical Imaging Science
https://www.readbyqxmd.com/read/29361245/brain-gliomas-multicenter-standardized-assessment-of-dynamic-contrast-enhanced-and-dynamic-susceptibility-contrast-mr-images
#14
Nicoletta Anzalone, Antonella Castellano, Marcello Cadioli, Gian Marco Conte, Valeria Cuccarini, Alberto Bizzi, Marco Grimaldi, Antonella Costa, Giovanni Grillea, Paolo Vitali, Domenico Aquino, Maria Rosa Terreni, Valter Torri, Bradley J Erickson, Massimo Caulo
Purpose To evaluate the feasibility of a standardized protocol for acquisition and analysis of dynamic contrast material-enhanced (DCE) and dynamic susceptibility contrast (DSC) magnetic resonance (MR) imaging in a multicenter clinical setting and to verify its accuracy in predicting glioma grade according to the new World Health Organization 2016 classification. Materials and Methods The local research ethics committees of all centers approved the study, and informed consent was obtained from patients. One hundred patients with glioma were prospectively examined at 3...
January 22, 2018: Radiology
https://www.readbyqxmd.com/read/29354207/dynamic-contrast-enhanced-magnetic-resonance-imaging-of-prostate-cancer-a-review-of-current-methods-and-applications
#15
REVIEW
Yousef Mazaheri, Oguz Akin, Hedvig Hricak
In many areas of oncology, dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) has proven to be a clinically useful, non-invasive functional imaging technique to quantify tumor vasculature and tumor perfusion characteristics. Tumor angiogenesis is an essential process for tumor growth, proliferation, and metastasis. Malignant lesions demonstrate rapid extravasation of contrast from the intravascular space to the capillary bed due to leaky capillaries associated with tumor neovascularity. DCE-MRI has the potential to provide information regarding blood flow, areas of hypoperfusion, and variations in endothelial permeability and microvessel density to aid treatment selection, enable frequent monitoring during treatment and assess response to targeted therapy following treatment...
December 28, 2017: World Journal of Radiology
https://www.readbyqxmd.com/read/29317433/improved-evaluation-of-antivascular-cancer-therapy-using-constrained-tracer-kinetic-modeling-for-multiagent-dynamic-contrast-enhanced-mri
#16
Stefanie J Hectors, Igor Jacobs, Jasper Lok, Johannes Peters, Johan Bussink, Freek J Hoeben, Henk M Keizer, Henk M Janssen, Klaas Nicolay, Matthias C Schabel, Gustav J Strijkers
Dynamic contrast-enhanced MRI (DCE-MRI) is a promising technique for assessing the response of tumor vasculature to antivascular therapies. Multiagent DCE-MRI employs a combination of low and high molecular weight contrast agents, which potentially improves the accuracy of estimation of tumor hemodynamic and vascular permeability parameters. In this study, we used multiagent DCE-MRI to assess changes in tumor hemodynamics and vascular permeability after vascular-disrupting therapy. Multiagent DCE-MRI (sequential injection of G5 dendrimer, G2 dendrimer, and Gd-DOTA) was performed in tumor-bearing mice before, 2 and 24 hours after treatment with vascular disrupting agent DMXAA or placebo...
March 15, 2018: Cancer Research
https://www.readbyqxmd.com/read/29262507/-measurement-reproducibility-of-parameters-derived-from-introvoxel-incoherent-motion-diffusion-weighted-mri-imaging-of-rectal-cancer
#17
Y K Meng, C D Zhang, H M Zhang, F Ye, H Ouyang, X M Zhao, K Xu, C W Zhou
Objective: To study the measurement reproducibility of parameters derived from introvoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI)-MRI of rectal cancer between- and within- radiologists. Methods: Clinical data of 34 patients with rectal cancer were prospective analyzed. Conventional MRI sequences, IVIM DWI-MRI with sixteen b values and dynamic contrast enhancement (DCE)-MRI sequences of rectum were acquired by GE 3.0-T MRI imager. The IVIM sequence images with b value=1000 sec/mm(2) were selected to measure the maximum axial section of tumor by a radiologist with 15 year-experiences in gastrointestinal cancer imaging...
December 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/29197390/evaluation-of-b-1-inhomogeneity-effect-on-dce-mri-data-analysis-of-brain-tumor-patients-at-3t
#18
Anirban Sengupta, Rakesh Kumar Gupta, Anup Singh
BACKGROUND: Dynamic-contrast-enhanced (DCE) MRI data acquired using gradient echo based sequences is affected by errors in flip angle (FA) due to transmit B1 inhomogeneity (B1 inh). The purpose of the study was to evaluate the effect of B1 inh on quantitative analysis of DCE-MRI data of human brain tumor patients and to evaluate the clinical significance of B1 inh correction of perfusion parameters (PPs) on tumor grading. METHODS: An MRI study was conducted on 35 glioma patients at 3T...
December 2, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29177134/automatic-detection-and-quantitative-dce-mri-scoring-of-prostate-cancer-aggressiveness
#19
Nestor Andres Parra, Alan Pollack, Felix M Chinea, Matthew C Abramowitz, Brian Marples, Felipe Munera, Rosa Castillo, Oleksandr N Kryvenko, Sanoj Punnen, Radka Stoyanova
Purpose: To develop a robust and clinically applicable automated method for analyzing Dynamic Contrast Enhanced (DCE-) MRI of the prostate as a guide for targeted biopsies and treatments. Materials and methods: An unsupervised pattern recognition (PR) method was used to analyze prostate DCE-MRI from 71 sequential radiotherapy patients. Identified regions of interest (ROIs) with increased perfusion were assigned either to the peripheral (PZ) or transition zone (TZ)...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/29159523/quantitating-whole-lesion-tumor-biology-in-rectal-cancer-mri-taking-a-lesson-from-fdg-pet-tumor-metrics
#20
Marc J Gollub, Andreas M Hotker, Kaitlin M Woo, Yousef Mazaheri, Mithat Gonen
PURPOSE: To determine the value of novel whole tumor metrics in DWI-MRI and DCE-MRI of rectal cancer treatment assessment. MATERIALS AND METHODS: This retrospective study included 24 uniformly treated patients with rectal adenocarcinoma who underwent MRI including diffusion-weighted (DW) and dynamic contrast-enhanced (DCE) sequences, before and after chemoradiotherapy. Two experienced readers independently measured tumor volume and apparent diffusion coefficient (ADC) on DWI-MRI and tumor volume and transfer constant Ktrans on DCE-MRI...
November 20, 2017: Abdominal Radiology
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