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https://www.readbyqxmd.com/read/29141310/-analysis-of-gene-mutation-of-early-onset-epileptic-spasm-with-unknown-reason
#1
X Yang, G Pan, W H Li, L M Zhang, B B Wu, H J Wang, P Zhang, S Z Zhou
Objective: To summarize the gene mutation of early onset epileptic spasm with unknown reason. Method: In this prospective study, data of patients with early onset epileptic spasm with unknown reason were collected from neurological department of Children's Hospital of Fudan University between March 2016 and December 2016. Patients with known disorders such as infection, metabolic, structural, immunological problems and known genetic mutations were excluded. Patients with genetic disease that can be diagnosed by clinical manifestations and phenotypic characteristics were also excluded...
November 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29126171/copy-number-variant-in-the-region-of-adenosine-kinase-adk-and-its-possible-contribution-to-schizophrenia-susceptibility
#2
Hiroki Kimura, Itaru Kushima, Akira Yohimi, Branko Aleksic, Norio Ozaki
Background: Adenosine kinase (ADK) is supposed to be a schizophrenia (SCZ) susceptibility gene based on the findings that ADK is an enzyme that catalyzes transfer of the gamma-phosphate from ATP to adenosine, which interacts with dopamine and glutamate, neurotransmitters. However, no reports of SCZ cases with loss of function variants in the ADK region have been published. In our previous study investigating copy number variants (CNV) in SCZ, we detected a CNV in the ADK region in one of 1699 SCZ patients...
November 6, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28940419/detection-of-copy-number-variations-in-epilepsy-using-exome-data
#3
N Tsuchida, M Nakashima, M Kato, E Heyman, T Inui, K Haginoya, S Watanabe, T Chiyonobu, M Morimoto, M Ohta, A Kumakura, M Kubota, Y Kumagai, S-I Hamano, C M Lourenco, N A Yahaya, G-S Ch'ng, L-H Ngu, A Fattal-Valevski, M W Hubshman, N Orenstein, D Marom, L Cohen, H Goldberg-Stern, Y Uchiyama, E Imagawa, T Mizuguchi, A Takata, N Miyake, H Nakajima, H Saitsu, S Miyatake, N Matsumoto
Epilepsies are common neurological disorders and genetic factors contribute to their pathogenesis. Copy number variations (CNVs) are increasingly recognized as an important etiology of many human diseases including epilepsy. Whole exome sequencing (WES) is becoming a standard tool for detecting pathogenic mutations and has recently been applied to detecting CNVs. Here, we analyzed 294 families with epilepsy using WES, and focused on 168 families with no causative single nucleotide variants (SNVs) in known epilepsy-associated genes to further validate CNVs using two different CNV detection tools using WES data...
September 22, 2017: Clinical Genetics
https://www.readbyqxmd.com/read/28846756/prevalence-of-pathogenic-copy-number-variation-in-adults-with-pediatric-onset-epilepsy-and-intellectual-disability
#4
Felippe Borlot, Brigid M Regan, Anne S Bassett, D James Stavropoulos, Danielle M Andrade
Importance: Copy number variation (CNV) is an important cause of neuropsychiatric disorders. Little is known about the role of CNV in adults with epilepsy and intellectual disability. Objectives: To evaluate the prevalence of pathogenic CNVs and identify possible candidate CNVs and genes in patients with epilepsy and intellectual disability. Design, Setting, and Participants: In this cross-sectional study, genome-wide microarray was used to evaluate a cohort of 143 adults with unexplained childhood-onset epilepsy and intellectual disability who were recruited from the Toronto Western Hospital epilepsy outpatient clinic from January 1, 2012, through December 31, 2014...
November 1, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28533195/de-novo-8p23-1-deletion-in-a-patient-with-absence-epilepsy
#5
Nihan Hande Akcakaya, Özlem Yalcin Capan, Herbert Schulz, Thomas Sander, Server Hande Caglayan, Zuhal Yapıcı
The 8p23.1 deletion syndrome is a rare multisystem disorder with high penetrance and a variable phenotypic spectrum that includes congenital heart disease (CHD), intellectual disability, behavioural problems, microcephalia, and sometimes epilepsy. Genomic copy number variations (CNVs) constitute an important genetic risk factor for common genetic generalised epilepsy syndromes (GGEs) and absence seizures. These variations, resulting either from copy loss (microdeletion) or copy gain (duplications), disrupt genes associated with neuronal development...
May 22, 2017: Epileptic Disorders: International Epilepsy Journal with Videotape
https://www.readbyqxmd.com/read/28074849/genetic-variants-identified-from-epilepsy-of-unknown-etiology-in-chinese-children-by-targeted-exome-sequencing
#6
Yimin Wang, Xiaonan Du, Rao Bin, Shanshan Yu, Zhezhi Xia, Guo Zheng, Jianmin Zhong, Yunjian Zhang, Yong-Hui Jiang, Yi Wang
Genetic factors play a major role in the etiology of epilepsy disorders. Recent genomics studies using next generation sequencing (NGS) technique have identified a large number of genetic variants including copy number (CNV) and single nucleotide variant (SNV) in a small set of genes from individuals with epilepsy. These discoveries have contributed significantly to evaluate the etiology of epilepsy in clinic and lay the foundation to develop molecular specific treatment. However, the molecular basis for a majority of epilepsy patients remains elusive, and furthermore, most of these studies have been conducted in Caucasian children...
January 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/27123475/analysis-of-rare-copy-number-variation-in-absence-epilepsies
#7
Laura Addis, Richard E Rosch, Antonio Valentin, Andrew Makoff, Robert Robinson, Kate V Everett, Lina Nashef, Deb K Pal
OBJECTIVE: To identify shared genes and pathways between common absence epilepsy (AE) subtypes (childhood absence epilepsy [CAE], juvenile absence epilepsy [JAE], and unclassified absence epilepsy [UAE]) that may indicate common mechanisms for absence seizure generation and potentially a diagnostic continuum. METHODS: We used high-density single-nucleotide polymorphism arrays to analyze genome-wide rare copy number variation (CNV) in a cohort of 144 children with AEs (95 CAE, 26 UAE, and 23 JAE)...
April 2016: Neurology. Genetics
https://www.readbyqxmd.com/read/26886358/progress-from-genome-wide-association-studies-and-copy-number-variant-studies-in-epilepsy
#8
REVIEW
Costin Leu, Antonietta Coppola, Sanjay M Sisodiya
PURPOSE OF REVIEW: The pace of gene discovery in epilepsy remains frenetic. Although most recent discoveries have come from next-generation sequencing studies, there has also been important progress using more established methodologies, such as genome-wide association studies (GWASs) and copy number variants (CNVs) identified through array-based techniques. Progress in these areas over the last year is reviewed. RECENT FINDINGS: The first meta-analysis of GWASs was a landmark development for the epilepsy community, though more sizeable studies are sorely needed...
April 2016: Current Opinion in Neurology
https://www.readbyqxmd.com/read/26658876/mouse-model-of-chromosome-15q13-3-microdeletion-syndrome-demonstrates-features-related-to-autism-spectrum-disorder
#9
Jeffrey H Kogan, Adam K Gross, Robert E Featherstone, Rick Shin, Qian Chen, Carrie L Heusner, Megumi Adachi, Amy Lin, Noah M Walton, Sosuke Miyoshi, Shinichi Miyake, Katsunori Tajinda, Hiroyuki Ito, Steven J Siegel, Mitsuyuki Matsumoto
UNLABELLED: The chromosome 15q13.3 microdeletion is a pathogenic copy number variation conferring epilepsy, intellectual disability, schizophrenia, and autism spectrum disorder (ASD). We generated mice carrying a deletion of 1.2 Mb homologous to the 15q13.3 microdeletion in human patients. Here, we report that mice with a heterozygous deletion on a C57BL/6 background (D/+ mice) demonstrated phenotypes including enlarged/heavier brains (macrocephaly) with enlarged lateral ventricles, decreased social interactions, increased repetitive grooming behavior, reduced ultrasonic vocalizations, decreased auditory-evoked gamma band EEG, and reduced event-related potentials...
December 9, 2015: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/26625664/myoclonic-astatic-epilepsy-in-a-patient-with-a-de-novo-4q21-22q21-23-microduplication
#10
V Ottaviani, A Bartocci, M Pantaleo, S Giglio, M Cecconi, A Verrotti, G Merla, G Stangoni, P Prontera
Myoclonicastatic epilepsy (MAE) is a rare form of symptomatic generalized epilepsy of uncertain etiology. To search the possible genetic basis of the disorder, here we investigate a 15 year-old patient with MAE, who is the only person presenting epilepsy in the family. High resolution array-CGH analysis was conducted on DNA extracted from peripheral blood of the patient and the parents. The copy number variant(s) (CNVs) identified were further confirmed by Fluorescent In Situ Hybridization (FISH). The array-CGH identified a de novo microduplication of about 778 Kb in the chromosome region 4q21...
2015: Genetic Counseling
https://www.readbyqxmd.com/read/26421275/genomic-copy-number-variation-affecting-genes-involved-in-the-cell-cycle-pathway-implications-for-somatic-mosaicism
#11
Ivan Y Iourov, Svetlana G Vorsanova, Maria A Zelenova, Sergei A Korostelev, Yuri B Yurov
Somatic genome variations (mosaicism) seem to represent a common mechanism for human intercellular/interindividual diversity in health and disease. However, origins and mechanisms of somatic mosaicism remain a matter of conjecture. Recently, it has been hypothesized that zygotic genomic variation naturally occurring in humans is likely to predispose to nonheritable genetic changes (aneuploidy) acquired during the lifetime through affecting cell cycle regulation, genome stability maintenance, and related pathways...
2015: International Journal of Genomics
https://www.readbyqxmd.com/read/26275332/copy-number-variants-associated-with-epilepsy-from-gene-expression-microarrays
#12
Dong Wang, Xia Li, Shanshan Jia, Yan Wang, Zhijing Wang, Xixiao Song, Liang Liu
We aimed to identify novel copy number variations (CNV) that might contribute to the pathogenesis of epilepsy. Epilepsy is a common brain disorder characterized by recurring seizures and various serious comorbidities, including respiratory, cardiovascular, and neurologic dysfunction. CNV have recently been considered as important risk factors for epilepsy. With public gene expression data from brain tissue of 23 epilepsy patients and 23 healthy controls, we detected CNV using the R language package CAFÉ. Real-time quantitative polymerase chain reaction validation was performed in a further nine patients and 10 controls...
December 2015: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/25923336/genome-wide-analysis-of-novel-copy-number-variations-duplications-deletions-of-different-epileptic-patients-in-saudi-arabia
#13
Muhammad Imran Naseer, Muhammad Faheem, Adeel G Chaudhary, Taha A Kumosani, Maha Mohsin Al-Quaiti, Mohammed M Jan, Hasan Saleh Jamal, Mohammad H Al-Qahtani
BACKGROUND: Epilepsy is genetically complex neurological disorder affecting millions of people of different age groups varying in its type and severity. Copy number variants (CNVs) are key players in the genetic etiology of numerous neurodevelopmental disorders and prior findings also revealed that chromosomal aberrations are more susceptible against the pathogenesis of epilepsy. Novel technologies, such as array comparative genomic hybridization (array-CGH), may help to uncover the pathogenic CNVs in patients with epilepsy...
2015: BMC Genomics
https://www.readbyqxmd.com/read/25921748/array-comparative-genomic-hybridization-analysis-of-a-cohort-of-saudi-patients-with-epilepsy
#14
Muhammad Faheem, Muhammad I Naseer, Adeel G Chaudhary, Taha A Kumosani, Mahmood Rasool, Hussein A Algahtani, Fehmida Bibi, Mohammad A Kamal, Mohammad H Al-Qahtani
Specific genetic anomalies or non-genetic factors could lead to epilepsy, but in various cases the underlying cause is unknown. Novel technologies, such as array comparative genomic hybridization, may reveal the copy number variants (CNVs), established as significant risk factor for epilepsy. This study carried out a high-density whole genome array- comparative genomic hybridization analysis with blood DNA samples from a cohort of twenty epilepsy patients to search for CNVs associated with epilepsy. Microdeletion of 14q31...
2015: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/25776725/genome-wide-analysis-of-novel-copy-number-variations-duplications-deletions-of-different-epileptic-patients-in-saudi-arabia
#15
Muhammad Imran Naseer, Muhammad Faheem, Adeel G Chaudhary, Taha A Kumosani, Maha Mohsin Al-Quaiti, Mohammed M Jan, Hasan Saleh Jamal, Mohammad H Al-Qahtani
BACKGROUND: Epilepsy is genetically complex neurological disorder affecting millions of people of different age groups varying in its type and severity. Copy number variants (CNVs) are key players in the genetic etiology of numerous neurodevelopmental disorders and prior findings also revealed that chromosomal aberrations are more susceptible against the pathogenesis of epilepsy. Novel technologies, such as array comparative genomic hybridization (array-CGH), may help to uncover the pathogenic CNVs in patients with epilepsy...
December 2015: BMC Genomics
https://www.readbyqxmd.com/read/25726360/rare-structural-genetic-variation-in-human-prion-diseases
#16
Ana Lukic, James Uphill, Craig A Brown, John Beck, Mark Poulter, Tracy Campbell, Gary Adamson, Holger Hummerich, Jerome Whitfield, Claudia Ponto, Inga Zerr, Sarah E Lloyd, John Collinge, Simon Mead
Prion diseases are a diverse group of neurodegenerative conditions, caused by the templated misfolding of prion protein. Aside from the strong genetic risk conferred by multiple variants of the prion protein gene (PRNP), several other variants have been suggested to confer risk in the most common type, sporadic Creutzfeldt-Jakob disease (sCJD) or in the acquired prion diseases. Large and rare copy number variants (CNVs) are known to confer risk in several related disorders including Alzheimer's disease (at APP), schizophrenia, epilepsy, mental retardation, and autism...
May 2015: Neurobiology of Aging
https://www.readbyqxmd.com/read/25705258/concomitant-deletion-of-chromosome-16p13-11-and-triplication-of-chromosome-19p13-3-in-a-child-with-developmental-disorders-intellectual-disability-and-epilepsy
#17
Elisa Tassano, Lucia Rosaia De Santis, Maria Franca Corona, Stefano Parmigiani, Dalila Zanetti, Simona Porta, Giorgio Gimelli, Cristina Cuoco
BACKGROUND: Rare copy number variations (CNVs) are today recognized as an important cause of various neurodevelopmental disorders, including mental retardation and epilepsy. In some cases, a second CNV may contribute to a more severe clinical presentation. RESULTS: Here we describe a patient with epilepsy, mental retardation, developmental disorders, and dysmorphic features, who inherited a deletion of 16p13.11 and a triplication of 19p13.3 from his father and mother, respectively...
2015: Molecular Cytogenetics
https://www.readbyqxmd.com/read/25596525/15q11-2-microdeletion-bp1-bp2-and-developmental-delay-behaviour-issues-epilepsy-and-congenital-heart-disease-a-series-of-52-patients
#18
Clémence Vanlerberghe, Florence Petit, Valérie Malan, Catherine Vincent-Delorme, Sonia Bouquillon, Odile Boute, Muriel Holder-Espinasse, Bruno Delobel, Bénédicte Duban, Louis Vallee, Jean-Marie Cuisset, Marie-Pierre Lemaitre, Marie-Christine Vantyghem, Marie Pigeyre, Sandrine Lanco-Dosen, Ghislaine Plessis, Marion Gerard, Matthieu Decamp, Michèle Mathieu, Gilles Morin, Guillaume Jedraszak, Frédéric Bilan, Brigitte Gilbert-Dussardier, Delphine Fauvert, Joëlle Roume, Valérie Cormier-Daire, Roseline Caumes, Jacques Puechberty, David Genevieve, Pierre Sarda, Lucie Pinson, Patricia Blanchet, Nathalie Lemeur, Frenny Sheth, Sylvie Manouvrier-Hanu, Joris Andrieux
Proximal region of chromosome 15 long arm is rich in duplicons that, define five breakpoints (BP) for 15q rearrangements. 15q11.2 microdeletion between BP1 and BP2 has been previously associated with developmental delay and atypical psychological patterns. This region contains four highly-conserved and non-imprinted genes: NIPA1, NIPA2, CYFIP1, TUBGCP5. Our goal was to investigate the phenotypes associated with this microdeletion in a cohort of 52 patients. This copy number variation (CNV) was prevalent in 0...
March 2015: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/25408897/nrxn1-deletions-identified-by-array-comparative-genome-hybridisation-in-a-clinical-case-series-further-understanding-of-the-relevance-of-nrxn1-to-neurodevelopmental-disorders
#19
Sarah Curran, Joo Wook Ahn, Hannah Grayton, David A Collier, Caroline Mackie Ogilvie
BACKGROUND: Microdeletions in the NRXN1 gene have been associated with a range of neurodevelopmental disorders, including autism spectrum disorders, schizophrenia, intellectual disability, speech and language delay, epilepsy and hypotonia. RESULTS: In the present study we performed array CGH analysis on 10,397 individuals referred for diagnostic cytogenetic analysis, using a custom oligonucleotide array, which included 215 NRXN1 probes (median spacing 4.9 kb). We found 34 NRXN1 deletions (0...
2013: Journal of Molecular Psychiatry
https://www.readbyqxmd.com/read/25255310/investigation-of-15q11-q13-16p11-2-and-22q13-cnvs-in-autism-spectrum-disorder-brazilian-individuals-with-and-without-epilepsy
#20
Danielle P Moreira, Karina Griesi-Oliveira, Ana L Bossolani-Martins, Naila C V Lourenço, Vanessa N O Takahashi, Kátia M da Rocha, Eloisa S Moreira, Estevão Vadasz, Joanna Goes Castro Meira, Debora Bertola, Eoghan O' Halloran, Tiago R Magalhães, Agnes C Fett-Conte, Maria Rita Passos-Bueno
Copy number variations (CNVs) are an important cause of ASD and those located at 15q11-q13, 16p11.2 and 22q13 have been reported as the most frequent. These CNVs exhibit variable clinical expressivity and those at 15q11-q13 and 16p11.2 also show incomplete penetrance. In the present work, through multiplex ligation-dependent probe amplification (MLPA) analysis of 531 ethnically admixed ASD-affected Brazilian individuals, we found that the combined prevalence of the 15q11-q13, 16p11.2 and 22q13 CNVs is 2.1% (11/531)...
2014: PloS One
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