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https://www.readbyqxmd.com/read/28812153/establishing-the-learning-curve-of-transanal-minimally-invasive-surgery-for-local-excision-of-rectal-neoplasms
#1
Lawrence Lee, Justin Kelly, George J Nassif, Deborah Keller, Teresa C Debeche-Adams, Paul A Mancuso, John R Monson, Matthew R Albert, Sam B Atallah
INTRODUCTION: Transanal minimally invasive surgery (TAMIS) is an endoscopic operating platform for local excision of rectal neoplasms. However, it may be technically demanding, and its learning curve has yet to be adequately defined. The objective of this study was to determine the number of TAMIS procedures for the local excision of rectal neoplasm required to reach proficiency. METHODS AND PROCEDURES: All TAMIS cases performed from 07/2009 to 12/2016 at a single high-volume tertiary care institution for local excision of benign and malignant rectal neoplasia were identified from a prospective database...
August 15, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28803235/18f-fdg-uptake-in-well-differentiated-neuroendocrine-tumors-correlates-with-both-ki-67-and-vhl-pathway-inactivation
#2
Margot Bucau, Astrid Laurent-Bellue, Nicolas Poté, Olivia Hentic, Jérôme Cros, Nidaa Mikail, Vinciane Rebours, Philippe Ruszniewski, Rachida Lebtahi, Anne Couvelard
<br>Introduction: 18FDG PET-scanner positivity correlates with poor prognosis in neuroendocrine neoplasms (NEN). Glucose transporter 1 (GLUT1) and carbonic anhydrase 9 (CA9) are markers of agressivity in tumors. Together with pVHL, they are involved in tumor cell metabolism via the hypoxia-inducible factor (HIF) signaling pathway. The aim of this study was to compare, in a series of well-differentiated neuroendocrine tumors (NET), the 18-FDG uptake and expression of proliferation marker Ki-67, GLUT-1, CA9 and pVHL...
August 11, 2017: Neuroendocrinology
https://www.readbyqxmd.com/read/28796731/quality-of-local-excision-for-rectal-neoplasms-using-transanal-endoscopic-microsurgery-versus-transanal-minimally-invasive-surgery-a-multi-institutional-matched-analysis
#3
Lawrence Lee, Kimberly Edwards, Iain A Hunter, John E Hartley, Sam B Atallah, Matthew R Albert, James Hill, John R Monson
BACKGROUND: There are no data comparing the quality of local excision of rectal neoplasms using transanal endoscopic microsurgery and transanal minimally invasive surgery. OBJECTIVE: The purpose of this study was to compare the incidence of tumor fragmentation and positive margins for patients undergoing local excision of benign and malignant rectal neoplasms using transanal endoscopic microsurgery versus transanal minimally invasive surgery. DESIGN: This was a multi-institutional cohort study using coarsened exact matching...
September 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/28791272/laparoscopic-repair-of-a-rectal-fistula-due-to-a-benign-ovarian-dermoid-cyst
#4
Ji Hye Kim, Gun Oh Chong, Da Som Chun, Soo Yeun Park, Yoon Hee Lee, Dae Gy Hong
Ovarian dermoid cysts are one of the most common benign neoplasms in women. Rectal fistula formation due to an ovarian dermoid cyst, particularly a benign dermoid cyst, is extremely rare. A 17-year-old girl with symptoms of lower abdominal pain, passage of sebaceous materials in the stool, and hematochezia was found to have an 11-cm dermoid cyst complicated with a rectal fistula formation. Laparoscopic repair of the rectal fistula was performed successfully with bilateral ovarian cystectomies. This case presents the rare formation of a fistula between a benign dermoid cyst and the rectum and its treatment using laparoscopic repair without laparotomy...
July 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/28733877/expanding-the-spectrum-of-colonic-manifestations-in-tuberous-sclerosis-l-cell-neuroendocrine-tumor-arising-in-the-background-of-rectal-pecoma
#5
David L Kolin, Kai Duan, Bo Ngan, J Ted Gerstle, Monika K Krzyzanowska, Gino R Somers, Ozgur Mete
Tuberous sclerosis complex (TSC) is an autosomal dominant neurocutaneous condition that predisposes to numerous proliferative lesions, including perivascular epithelioid cell tumors (PEComas), such as lymphangioleiomyomatosis (LAM) and angiomyolipomas, and rare neuroendocrine neoplasms. We describe herein a TSC2-harboring tuberous sclerosis patient manifesting with a synchronous well-differentiated L-cell rectal neuroendocrine tumor and leiomyomatosis-like LAM of the rectum. The background large bowel wall was thickened by confluent nodular areas comprising vessels and spindle-to-epithelioid cells, which are immunoreactive for myoid (smooth muscle actin, muscle specific actin, and desmin) and melanocytic markers (HMB45, Melan-A, microphthalmia transcription factor, and CD117)...
July 21, 2017: Endocrine Pathology
https://www.readbyqxmd.com/read/28718368/remodeling-of-extracellular-matrix-of-the-lamina-propria-in-the-uninvolved-human-rectal-mucosa-10-and-20%C3%A2-cm-away-from-the-malignant-tumor
#6
Sanja Z Despotović, Novica M Milićević, Dragoslav P Milošević, Nebojša Despotović, Predrag Erceg, Petar Svorcan, Udo Schumacher, Sebastian Ullrich, Gordana Mihajlović, Dragan Kalem, Srđan Marković, Ivana M Lalić, Aleksandar J Krmpot, Mihailo D Rabasović, Dejan V Pantelić, Svetlana Z Jovanić, Thomas Rösch, Živana Milićević
In recent years, it has been demonstrated that malignancy arises and advances through the molecular interplay between tumor cells and non-malignant elements of the tumor stroma, that is, fibroblasts and extracellular matrix. However, in contrast to the mounting evidence about the role of tumor stroma in the genesis and progression of the malignant disease, there are very few data regarding the uninvolved stromal tissue in the remote surrounding of the tumor. Using the objective morphometric approach in patients with adenocarcinoma, we demonstrate the remodeling of extracellular matrix of the lamina propria in the uninvolved rectal mucosa 10 and 20 cm away from the neoplasm...
July 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28687087/a-rare-case-of-malignant-solitary-fibrous-tumor-in-prostate-with-review-of-the-literature
#7
Andrea Ronchi, Elvira La Mantia, Vincenzo Gigantino, Sisto Perdonà, Marco De Sio, Gaetano Facchini, Renato Franco, Annarosaria De Chiara
BACKGROUND: Solitary fibrous tumor is an uncommon soft tissue neoplasm with intermediate biological behavior, which rarely metastasizes. Malignant solitary fibrous tumor, although not clearly defined, is rarely described in the prostate. The present case is characterized by some peculiarities if compared with previously reported cases of prostatic malignant solitary fibrous tumor. Firstly, it does not show a homogeneous morphology: part of the neoplasm (about 50%) showed the features of a conventional solitary fibrous tumor, while the remaining part showed the features of a malignant solitary fibrous tumor...
July 7, 2017: Diagnostic Pathology
https://www.readbyqxmd.com/read/28684185/transabdominal-ultrasound-colonography-for-detection-of-colorectal-neoplasms-initial-clinical-experience
#8
Jin-Ya Liu, Li-Da Chen, Jian-Bo Xu, Hui Wu, Jin-Ning Ye, Xin-Hua Zhang, Xiao-Yan Xie, Wei Wang, Ming-De Lu
We investigated the feasibility of using ultrasound colonography (USC) to visualize the healthy colon and rectum and detect colorectal polyps. Eight healthy volunteers underwent USC after standard bowel preparation. The feasibility and image quality of USC in different segments were evaluated. Then, USC was conducted on eight patients with known colonic neoplasms using colonoscopy as the reference standard. For volunteers, USC examinations were successfully performed on four (50.0%) ascending, three (37.5%) transverse and eight (100%) descending colons, as well as all sigmoid colons and rectums...
July 3, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28677418/metastatic-myxosarcoma-in-a-quarter-horse-gelding
#9
Jonathan P Samuelson, Kate O Echeverria, Jonathan H Foreman, Richard L Fredrickson, Deborah Sauberli, Herbert E Whiteley
A 22-y-old Quarter Horse gelding was presented to the University of Illinois Veterinary Teaching Hospital for evaluation of increased heart rate and mild colic signs. Rectal examination revealed a large left perirenal mass. Abdominal ultrasonography further confirmed this finding. Thoracic ultrasonography indicated multifocal irregularities on the pleural surface suggestive of consolidation and possibly masses in the lungs. The animal was euthanized. Autopsy findings included a large, firm, expansile, gelatinous retroperitoneal mass that surrounded both kidneys, as well as nodules with similar morphology in the lungs, liver, intestinal mesentery, cecum, and caudal mesenteric artery...
July 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28677025/calcium-as-a-chemopreventive-agent-against-colorectal-neoplasm-does-obesity-play-a-role
#10
NaNa Keum, Hanseul Kim, Edward L Giovannucci
BACKGROUND: Concerning the chemopreventive potential of calcium against colorectal neoplasms, strong evidence from initial randomized controlled trials (RCTs) of colorectal adenoma has not been confirmed from the most recent large RCT. To explain the conflicting results, a new hypothesis was proposed that the benefit of calcium may be confined to lean individuals. METHODS: To test this hypothesis, we examined heterogeneity of the associations of calcium intake with adenoma and CRC, using data from the most recent meta-analyses of observational studies and conducting subgroup analysis by average body mass index (BMI) of study population...
July 4, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28673644/a-rectal-metastases-from-malignant-mucinous-cystic-neoplasm-of-the-pancreas-mimicking-a-rectal-carcinoma
#11
Silvia Carrara, Milena Di Leo, Paola Spaggiari, Pietro Francesco Bagnoli, Alessandro Repici
No abstract text is available yet for this article.
June 30, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28670078/b-lymphoblastic-lymphoma-of-the-rectum
#12
Puthillathu Unnikrishnan, Geetha Narayanan, Bhavya S Kumar, Nandini Devi
Lymphoblastic lymphoma is a neoplasm of immature cells committed to the B-cell or T-cell lineage. B-lymphoblastic lymphoma usually involves lymph nodes and extranodal sites, such as the skin, bone, and soft tissue. The rectum is a very rare site of involvement in B-lymphoblastic lymphoma. We describe a 26-year-old man who presented with bleeding per rectum and fecal incontinence. Endoscopy showed a large nodular friable lesion narrowing the entire rectal lumen. Biopsy was diagnostic of B-lymphoblastic lymphoma...
July 2017: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/28667499/two-stage-turnbull-cutait-pull-through-coloanal-anastomosis-versus-coloanal-anastomosis-with-protective-loop-ileostomy-for-low-rectal-cancer-protocol-for-a-randomized-controlled-trial-turnbull-bcn
#13
Sebastiano Biondo, Loris Trenti, Ana Galvez, Eloy Espin-Basany, Francesco Bianco, Giovanni Romano, Esther Kreisler
PURPOSE: The aim of this study was to determine whether patients that underwent ultra-low rectal resection for cancer can benefit from the recently reintroduced two-stage Turnbull-Cutait abdominoperineal pull-through procedure. METHODS: Patients with low rectal tumors undergoing radical sphincter-sparing resection are eligible for inclusion in a randomized multicenter study. Whether two-stage Turnbull-Cutait coloanal anastomosis provides significant benefits over hand-sewn coloanal anastomosis and associated lateral ileostomy in terms of postoperative morbidity is the primary endpoint...
June 30, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28660992/all-that-glitters-on-pet-is-not-cancer-18f-deoxy-glucose-avidity-versus-tumor-biology-pituitary-incidentaloma-in-a-survivor-of-two-previous-unrelated-malignancies
#14
Dragana Miljić, Emilija Manojlović-Gačić, Milica Skender-Gazibara, Toplica Milojević, Vojislav Bogosavljević, Nebojša Kozarević, Nebojša Petrović, Marko Stojanović, Sandra Pekić, Mirjana Doknić, Milan Petakov, Vera Popović
INTRODUCTION: 18F-deoxy-glucose positron emission tomography combined with computed tomography (18F-FDG PET/CT) is routinely used in the detection of malignant disease based on the property of malignant cells to fuel their growth and replication by increased glucose uptake. Malignant lesions are rare in the sellar region, while pituitary adenomas are the most common pathology. These are benign neoplasms with insidious onset and low proliferation activity, and therefore are only exceptionally detected by 18F-FDG PET/CT...
2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28656075/value-of-macrobiopsies-and-transanal-endoscopic-microsurgery-in-the-histological-work-up-of-rectal-neoplasms-a-retrospective-study
#15
Guus M J Bökkerink, Gert-Jan van der Wilt, Dirk de Jong, Han H J M van Krieken, Robert P Bleichrodt, Johannes H W de Wilt, Andreas J A Bremers
AIM: To evaluate a step up approach: Taking macrobiopsies and performing excision biopsies in patients with suspected rectal cancer in which biopsies taken though the flexible endoscope showed benign histology. METHODS: Patients with a rectal neoplasm who underwent flexible endoscopy and biopsies were included. In case of benign biopsies rigid rectoscopy and macrobiopsies were employed. If this failed to prove malignancy, transanal endoscopic microsurgery (TEM) was used in a final effort to establish a certain preoperative diagnosis...
June 15, 2017: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28638446/overexpression-of-transcobalamin-1-is-an-independent-negative-prognosticator-in-rectal-cancers-receiving-concurrent-chemoradiotherapy
#16
Yi-Ying Lee, Yu-Ching Wei, Yu-Feng Tian, Ding-Ping Sun, Ming-Jen Sheu, Ching-Chieh Yang, Li-Ching Lin, Chen-Yi Lin, Chung-Hsi Hsing, Wan-Shan Li, Chien-Feng Li, Pei-Ling Hsieh, Ching-Yih Lin
Objective: Neoadjuvant concurrent chemoradiotherapy (CCRT) is an increasingly common therapeutic strategy for locally advanced rectal cancer, but stratification of risk and final outcomes remain a major challenge. Transcobalamin 1 (TCN1), a vitamin B12 (cobalamin)-binding protein, regulates cobalamin homeostasis. High expression of TCN1 have been reported in neoplasms such as breast cancer and hepatocellular carcinoma. However, little is known about the relevance of TCN1 to rectal cancer receiving CCRT. This study examined the predictive and prognostic impact of TCN1 expression in patients with rectal cancer following neoadjuvant CCRT...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28625066/a-rectal-neuroendocrine-neoplasm
#17
Modesto J Varas Lorenzo, Fernando Muñoz Agel
The incidence of gastric and rectal carcinoids is increasing. This is probably due to endoscopic screening. The prognosis is primarily dependent upon tumor size, aggressiveness (pathology, Ki-67), metastatic disease and stage. However, neuroendocrine carcinoma usually behaves as an adenocarcinoma.
June 19, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28623399/endothelial-dysfunction-in-rectal-cancer-patients-chronically-exposed-to-ionizing-radiation
#18
Tolebay Rakhypbekov, Ken Inoue, Laura Pak, Noriyuki Kawano, Nobuo Takeichi, Masaharu Hoshi, Yoshihiro Noso, Nailya Chaizhunusova, Zukhra Manambayeva, Arman Khozhayev, Maulen Molgazhdarov, Sayakhat Olzhaev, Sholpan Tokanova, Madina Madiyeva
We sought to identify the features of endothelial function in rectal cancer patients who were exposed to chronic ionizing radiation from a nuclear test site in Kazakhstan. We examined 146 individuals, 76 of whom were rectal cancer patients. The existence of a complex of disturbances of the endothelium and hemostasis systems in patients vs non-patients was revealed. Endothelial dysfunction was expressed as an increase of nitric oxide (NO) production along with decreases in vasodilatation function, and increased levels of von Willebrand factor in blood, along with an increase in the number of circulating endotheliocytes...
August 2017: Radiation and Environmental Biophysics
https://www.readbyqxmd.com/read/28590345/two-cases-of-epithelioid-trophoblastic-tumors-in-postmenopausal-women
#19
Adriano Rodríguez-Trujillo, María José Martínez-Serrano, Adela Saco, Aureli Torné
OBJECTIVE: Epithelioid trophoblastic tumor is a rare gestational trophoblastic neoplasm usually presenting in women of reproductive age, with a history of a prior gestational event. Its presentation in postmenopausal women is extremely rare. Immunohistochemical staining is a helpful aid to distinguish epithelioid trophoblastic tumor from other gestational trophoblastic neoplasms. Correct diagnosis is crucial for clinical management that can vary according to the type of gestational trophoblastic neoplasm...
June 5, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28540975/colorectal-neuroendocrine-neoplasms-management-guidelines-recommended-by-the-polish-network-of-neuroendocrine-tumours
#20
Teresa Starzyńska, Magdalena Londzin-Olesik, Agata Bałdys-Waligórska, Tomasz Bednarczuk, Jolanta Blicharz-Dorniak, Marek Bolanowski, Agnieszka Boratyn-Nowicka, Małgorzata Borowska, Andrzej Cichocki, Jarosław B Ćwikła, Andrzej Deptała, Massimo Falconi, Wanda Foltyn, Daria Handkiewicz-Junak, Alicja Hubalewska-Dydejczyk, Barbara Jarząb, Roman Junik, Dariusz Kajdaniuk, Grzegorz Kamiński, Agnieszka Kolasińska-Ćwikła, Aldona Kowalska, Robert Król, Leszek Królicki, Jolanta Kunikowska, Katarzyna Kuśnierz, Paweł Lampe, Dariusz Lange, Anna Lewczuk-Myślicka, Andrzej Lewiński, Michał Lipiński, Bogdan Marek, Anna Nasierowska-Guttmejer, Ewa Nowakowska-Duława, Joanna Pilch-Kowalczyk, Piotr Remiszewski, Violetta Rosiek, Marek Ruchała, Lucyna Siemińska, Anna Sowa-Staszczak, Katarzyna Steinhof-Radwańska, Janusz Strzelczyk, Krzysztof Sworczak, Anhelli Syrenicz, Andrzej Szawłowski, Marek Szczepkowski, Ewa Wachuła, Wojciech Zajęcki, Anna Zemczak, Wojciech Zgliczyński, Beata Kos-Kudła
Neuroendocrine neoplasms/tumours (NENs/NETs) of the large intestine are detected increasingly often, especially rectal tumours, which is probably associated with the widespread use of screening colonoscopy. There is a growing body of evidence supporting the thesis that the NENs of the rectum and the NENs of the colon are two different diseases. Rectal NENs are usually small lesions, of low to moderate histological malignancy, associated with good prognosis, and most may be treated endoscopically. NENs of the colon, however, are often aggressive, poorly differentiated, associated with a poor or uncer-tain prognosis, and require surgical treatment...
2017: Endokrynologia Polska
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