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https://www.readbyqxmd.com/read/27903339/-effect-of-goal-directed-haemodynamic-management-on-the-postoperative-outcome-in-elderly-patients-with-fragile-cardiac-function-undergoing-abdominal-surgery
#1
L S Zheng, E W Gu, X H Peng, L Zhang, Y Y Cao
Objective: To investigate the effect of goal-directed haemodynamic management based on stroke volume variation (SVV), cardiac index (CI) and mean arterial blood pressure (MAP) on the postoperative outcome in elderly patients with fragile cardiac function undergoing gastrointestinal surgery. Methods: Ninety patients with fragile cardiac function, aged 65-90 years old, ASAⅡ or Ⅲ, NYHA Ⅱor Ⅲ, scheduled for abdominal surgery were enrolled in this study.The patients were randomly assigned to two groups: Experience anesthesia group (group E, n=45) and goal-directed hemodynamic management group (G group, n=45)...
November 22, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27894293/lung-bioengineering-physical-stimuli-and-stem-progenitor-cell-biology-interplay-towards-biofabricating-a-functional-organ
#2
REVIEW
Paula N Nonaka, Juan J Uriarte, Noelia Campillo, Vinicius R Oliveira, Daniel Navajas, Ramon Farré
A current approach to obtain bioengineered lungs as a future alternative for transplantation is based on seeding stem cells on decellularized lung scaffolds. A fundamental question to be solved in this approach is how to drive stem cell differentiation onto the different lung cell phenotypes. Whereas the use of soluble factors as agents to modulate the fate of stem cells was established from an early stage of the research with this type of cells, it took longer to recognize that the physical microenvironment locally sensed by stem cells (e...
November 28, 2016: Respiratory Research
https://www.readbyqxmd.com/read/27887828/occupational-health-risk-assessment-and-exposure-to-floor-dust-pahs-inside-an-educational-building
#3
Androniki Maragkidou, Sharif Arar, Afnan Al-Hunaiti, Yuning Ma, Stuart Harrad, Omar Jaghbeir, Dina Faouri, Kaarle Hämeri, Tareq Hussein
Polycyclic aromatic hydrocarbons (PAHs) settled in floor dust play an important role in human health. Although many studies investigated occupational exposure to PAHs, no attempts have been made to report PAHs concentrations as well as their health risk assessment inside an educational building in Jordan. Therefore, the main objective of this study is to report the PAHs concentrations in floor dust and evaluate their exposure and health risk inside the Department of Physics of the University of Jordan. The total PAHs concentrations ranged from 714 to 5246ng/g...
November 22, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27881405/effectiveness-of-individualised-lung-recruitment-strategies-at-birth-an-experimental-study-in-preterm-lambs
#4
David G Tingay, Anushi E Rajapaksa, Emanuela Zannin, Prue M Pereira-Fantini, Raffaele Dellacà, Elizabeth Perkins, Cornelis Elroy E Zonneveld, Andy Adler, Don Black, Inez Frerichs, Anna Lavizzari, Magdy Sourial, Bartłomiej Grychtol, Fabio Mosca, Peter G Davis
Respiratory transition at birth involves rapidly clearing fetal lung liquid and preventing efflux back into the lung whilst aeration is established. We have developed a sustained inflation (SIOPT) individualized to volume-response and a dynamic tidal positive end-expiratory pressure (open lung volume, OLV) strategy that both enhance this process. We aimed to compare the effect of each with a group managed with PEEP of 8 cmH2O and no recruitment manoeuvre (No-RM), on gas exchange, lung mechanics, spatiotemporal aeration and lung injury in 127±1d preterm lambs...
November 23, 2016: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/27875936/characterization-of-dust-from-blast-furnace-cast-house-de-dusting
#5
Christof Lanzerstorfer
During casting of liquid iron and slag a considerable amount of dust is emitted into the cast house of a blast furnace. Usually, this dust is extracted via exhaust hoods and subsequently separated from the ventilation air. In most blast furnaces the cast house dust is recycled. In this study a sample of cast house dust was split by air classification into five size fractions which were then analysed. Micrographs showed that the dominating particle type in all size fractions is that of single spherical-shaped particles...
November 23, 2016: Environmental Technology
https://www.readbyqxmd.com/read/27873331/low-tidal-volume-reduces-lung-inflammation-induced-by-liquid-ventilation-in-piglets-with-severe-lung-injury
#6
Lijun Jiang, Huizhen Feng, Xiaofan Chen, Kaifeng Liang, Chengyao Ni
Total liquid ventilation (TLV) is an alternative treatment for severe lung injury. High tidal volume is usually required for TLV to maintain adequate CO2 clearance. However, high tidal volume may cause alveolar barotrauma. We aim to investigate the effect of low tidal volume on pulmonary inflammation in piglets with lung injury and under TLV. After the establishment of acute lung injury model by infusing lipopolysaccharide, 12 piglets were randomly divided into two groups, TLV with high tidal volume (25 mL/kg) or with low tidal volume (6 mL/kg) for 240 min, respectively...
November 21, 2016: Artificial Organs
https://www.readbyqxmd.com/read/27865481/the-influence-of-tethering-and-gravity-on-the-stability-of-compliant-liquid-lined-airways
#7
Jeremy Whang, Chandler Faulman, Thomas A Itin, Donald P Gaver
This study revolves around two simple questions: 1) how does pulmonary airway recruitment/de-recruitment (RecDer) depend on the tethering support provided by surrounding airways and alveoli, and 2) does airway angle of inclination (θ) influence airway stability? These two questions are critical to understanding the existence and prevention of atelectrauma, which may contribute to ventilator-induced lung injury (VILI). To address these questions, we develop PDMS 2mm ID compliant tubes that mimic pulmonary airways...
November 11, 2016: Journal of Biomechanics
https://www.readbyqxmd.com/read/27830441/successful-use-of-veno-venous-extracorporeal-membrane-oxygenation-as-a-bridge-to-lung-t-transplantation-in-a-patient-with-pulmonary-fibrosis
#8
Nao Umei, Shingo Ichiba, Masayuki Chida
As the Japanese organ donor allocation system does not permit the allocation of lungs at a priority level to patients on extracorporeal membrane oxygenation (ECMO), many of these patients die before suitable donor lungs become available. We report our first experience with ECMO as a bridge to lung transplantation (LTx) from a brain-dead donor. A 40-year-old man with interstitial lung disease who was listed for LTx 3 years previously, experienced progressive deterioration of respiratory function. He was mechanically ventilated at another hospital and was transported to our hospital due to severe hypoxemia...
November 9, 2016: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27785790/laboratory-evaluation-of-a-novel-anaesthesia-delivery-device
#9
A Paul, J N Clark, I E Salama, B J Jenkins, N Goodwin, A R Wilkes, P F Mahoney, J E Hall
Here, we describe proof of concept of a novel method for delivering volatile anaesthetics, where the liquid anaesthetic (sevoflurane or isoflurane) is formulated into an emulsion that is contained in a compact, lightweight device through which carrier gas flows. Release of anaesthetic is achieved by stirring of the formulation, allowing controlled and responsive release of anaesthetic at a variety of fixed flow rates between 0.5 l.min(-1) and 5 l.min(-1) , with ventilated, non-ventilated and draw-over breathing systems...
October 26, 2016: Anaesthesia
https://www.readbyqxmd.com/read/27769306/improved-application-technique-of-albumin-glutaraldehyde-glue-for-repair-of-superficial-lung-defects
#10
Maximilian Bures, Patrick Zardo, Florian Länger, Ruoyu Zhang
BACKGROUND: Albumin-glutaraldehyde glue has gained widespread acceptance for treatment of alveolar air leaks (AAL) in thoracic surgery. As liquid run-off during application is detrimental to its sealing efficacy, we developed a modified technique and assessed it in vitro. METHODS: Caudal lobes of freshly excised swine lungs (n = 20) were intubated and ventilated. A standardized focal superficial parenchymal defect (40 × 25 mm) was created on the inflated lung...
October 21, 2016: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/27755181/sore-throat-following-three-adult-supraglottic-airway-devices-a-randomised-controlled-trial
#11
Joël L'Hermite, Elisabeth Dubout, Sophie Bouvet, Laure-Hélène Bracoud, Philippe Cuvillon, Jean-Emmanuel de La Coussaye, Jacques Ripart
BACKGROUND: Sore throat is a common complaint after surgery. It affects patient satisfaction and can affect activity after discharge. The supraglottic airway device (SAD) offers an alternative to traditional tracheal intubation with potential benefit in preventing sore throat. OBJECTIVE: The aim of this study was to compare the incidence of sore throat following three different SADs, the laryngeal mask airway Unique (LMA-U) and the more recent LMA Supreme (LMA-S) and the I-gel...
October 15, 2016: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/27690196/studies-on-fluid-dynamics-of-the-flow-field-and-gas-transfer-in-orbitally-shaken-tubes
#12
Li-Kuan Zhu, Dominique T Monteil, Xiao Shen, David L Hacker, Bo-Yan Song, Zhen-Long Wang, Maria De Jesus, Florian M Wurm
Orbitally shaken cylindrical bioreactors [OrbShake bioreactors (OSRs)] without an impeller or sparger are increasingly being used for the suspension cultivation of mammalian cells. Among small volume OSRs, 50-ml tubes with a ventilated cap (OSR50), originally derived from standard laboratory centrifuge tubes with a conical bottom, have found many applications including high-throughput screening for the optimization of cell cultivation conditions. To better understand the fluid dynamics and gas transfer rates at the liquid surface in OSR50, we established a three-dimensional simulation model of the unsteady liquid forms (waves) in this vessel...
September 30, 2016: Biotechnology Progress
https://www.readbyqxmd.com/read/27684296/determination-of-colistin-and-colistimethate-levels-in-human-plasma-and-urine-by-high-performance-liquid-chromatography-tandem-mass-spectrometry
#13
Kevin Bihan, Qin Lu, Manon Enjalbert, Maxime Apparuit, Olivier Langeron, Jean-Jacques Rouby, Christian Funck-Brentano, Noël Zahr
BACKGROUND: Colistin is a polypeptide antibiotic from the polymyxin E group used for the treatment of infections caused by multidrug-resistant gram-negative bacteria. The main constituents, accounting for approximately 85% of this mixture, are colistin A (polymyxin E1) and colistin B (polymyxin E2). The aim of this study was to develop and validate new and fast methods of quantification of colistin A and B and its precursors [colistin methanesulfonate sodium (CMS) A and B] by ultraperformance liquid chromatography-tandem mass spectrometry in plasma and urine with short pretreatment and run times...
December 2016: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/27648139/liquid-extracorporeal-carbon-dioxide-removal-use-of-tham-tris-hydroxymethyl-aminomethane-coupled-to-hemofiltration-to-control-hypercapnic-acidosis-in-a-porcine-model-of-protective-mechanical-ventilation
#14
Pablo Tapia, Felipe Lillo, Dagoberto Soto, Leslie Escobar, Felipe Simon, Karina Hernández, Leyla Alegría, Alejandro Bruhn
A promising approach to facilitate protective mechanical ventilation is the use of extracorporeal CO2 removal techniques. Several strategies based on membrane gas exchangers have been developed. However, these techniques are still poorly available. The goal of this study was to assess the efficacy and safety of THAM infusion coupled to hemofiltration for the management of hypercapnic acidosis. A severe respiratory acidosis was induced in seven anesthetized pigs. Five of them were treated with THAM 8-mmol·kg(-1)·h(-1) coupled to hemofiltration (THAM+HF group) at 100 mL·kg(-1)·h(-1)...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27537903/a-well-mixed-computational-model-for-estimating-room-air-levels-of-selected-constituents-from-e-vapor-product-use
#15
Ali A Rostami, Yezdi B Pithawalla, Jianmin Liu, Michael J Oldham, Karl A Wagner, Kimberly Frost-Pineda, Mohamadi A Sarkar
Concerns have been raised in the literature for the potential of secondhand exposure from e-vapor product (EVP) use. It would be difficult to experimentally determine the impact of various factors on secondhand exposure including, but not limited to, room characteristics (indoor space size, ventilation rate), device specifications (aerosol mass delivery, e-liquid composition), and use behavior (number of users and usage frequency). Therefore, a well-mixed computational model was developed to estimate the indoor levels of constituents from EVPs under a variety of conditions...
2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27414793/-determination-of-proteomic-and-metabolic-composition-of-exhaled-breath-condensate-of-newborns
#16
A S Kononikhin, V V Chagovets, N L Starodubtseva, A Y Ryndin, A E Bugrova, Y I Kostyukevich, I A Popov, V E Frankevich, O V Ionov, G T Sukhikh, E N Nikolaev
Here, the possibility of proteomic and metabolomic analysis of the composition of exhaled breath condensate of neonates with respiratory support. The developed method allows non-invasive collecting sufficient amount of the material for identification of disease-specific biomarkers. Samples were collected by using a condensing device that was incorporated into the ventilation system. The collected condensate was analyzed by liquid chromatography coupled with high resolution mass spectrometry and tandem mass spectrometry...
May 2016: Molekuliarnaia Biologiia
https://www.readbyqxmd.com/read/27382463/high-bacterial-load-of-indoor-air-in-hospital-wards-the-case-of-university-of-gondar-teaching-hospital-northwest-ethiopia
#17
Zemichael Gizaw, Mulat Gebrehiwot, Chalachew Yenew
BACKGROUND: The air inhaled by people is abundantly populated with microorganisms which also are called bioaerosols. Bioaerosols is a colloidal suspension, formed by liquid droplets and particles of solid matter in the air, whose components contain or have attached to them viruses, fungal spores and conidia, bacterial endospores, plant pollen and fragments of plant tissues. They account for 5-34 % of indoor air pollution. METHODS: A cross-sectional study was conducted to assess the bacteriological concentration and to identify specific species of bacteria in the indoor air of Gondar University teaching hospital...
2016: Multidisciplinary Respiratory Medicine
https://www.readbyqxmd.com/read/27302836/ammonia-emissions-from-an-anaerobic-digestion-plant-estimated-using-atmospheric-measurements-and-dispersion-modelling
#18
Michael W Bell, Y Sim Tang, Ulrike Dragosits, Chris R Flechard, Paul Ward, Christine F Braban
Anaerobic digestion (AD) is becoming increasingly implemented within organic waste treatment operations. The storage and processing of large volumes of organic wastes through AD has been identified as a significant source of ammonia (NH3) emissions, however the totality of ammonia emissions from an AD plant have not been previously quantified. The emissions from an AD plant processing food waste were estimated through integrating ambient NH3 concentration measurements, atmospheric dispersion modelling, and comparison with published emission factors (EFs)...
October 2016: Waste Management
https://www.readbyqxmd.com/read/27294854/pediatric-burns-a-single-institution-retrospective-review-of-incidence-etiology-and-outcomes-in-2273-burn-patients-1995-2013
#19
Christina J Lee, Krishnaraj Mahendraraj, Abraham Houng, Michael Marano, Sylvia Petrone, Robin Lee, Ronald S Chamberlain
Unintentional burn injury is the third most common cause of death in the U.S. for children age 5 to 9, and accounts for major morbidity in the pediatric population. Pediatric burn admission data from U.S. institutions has not been reported recently. This study assesses all pediatric burn admissions to a State wide Certified Burn Treatment Center to evaluate trends in demographics, burn incidence, and cause across different age groups. Demographic and clinical data were collected on 2273 pediatric burn patients during an 18-year period (1995-2013)...
June 2, 2016: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/27278344/reduced-dimension-modeling-approach-for-simulating-recruitment-de-recruitment-dynamics-in-the-lung
#20
Jason Ryans, Hideki Fujioka, David Halpern, Donald P Gaver
Acute respiratory distress syndrome is a pulmonary disease that requires the use of mechanical ventilation for patient recovery. However, this can lead to development of ventilator-induced lung injury caused by the over-distension of alveolar tissue and by the repetitive closure (de-recruitment) and reopening (recruitment) of airways. In this study, we developed a multi-scale model of the lung from a reduced-dimension approach to investigate the dynamics of ventilation in the lung during airway collapse and reopening...
December 2016: Annals of Biomedical Engineering
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