Shirin Emtenani, Maike M Holtsche, Richard Stahlkopf, Daniel L Seiler, Timothy Burn, Huiqing Liu, Melissa Parker, Kaan Yilmaz, Hasan O Dikmen, Markus Huber Lang, Christian D Sadik, Christian M Karsten, Nina van Beek, Ralf J Ludwig, Jörg Köhl, Enno Schmidt
Bullous pemphigoid (BP), the by far most frequent autoimmune subepidermal blistering disorder (AIBD), is characterized by the deposition of autoantibodies against BP180 (type XVII collagen; Col17) and BP230 as well as complement components at the dermal-epidermal junction (DEJ). The mechanisms of complement activation in BP patients, including the generation of C5a and regulation of its two cognate C5aRs, i.e., C5aR1 and C5aR2, are incompletely understood. In this study, transcriptome analysis of perilesional and non-lesional skin biopsies of BP patients compared to site-, age-, and sex-matched controls showed an upregulated expression of C5AR1 , C5AR2 , CR1 , and C3AR1 and other complement-associated genes in perilesional BP skin...
2022: Frontiers in Immunology