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https://www.readbyqxmd.com/read/29682739/bullous-pemphigoid-induced-by-dipeptidyl-peptidase-4-inhibitors-eight-cases-with-clinical-and-immunological-characterization
#1
Irene García-Díez, Marta Ivars-Lleó, Daniel López-Aventín, Norito Ishii, Takashi Hashimoto, Pilar Iranzo, Ramon M Pujol, Agustín España, Josep E Herrero-Gonzalez
BACKGROUND: Dipeptidyl peptidase-4 (DPP-4) inhibitors have increasingly been identified as causative agents of bullous pemphigoid. The clinical and immunological characteristics of this pemphigoid variant are still unclear. The objective of our study was to analyze the clinical and immunological features of patients with pemphigoid induced by DPP-4 inhibitors. METHODS: All patients diagnosed with DPP-4 inhibitor-associated bullous pemphigoid at dermatology departments in three Spanish centers during the period 2013 to 2015 were included...
April 23, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29662486/mucosal-involvement-in-bullous-pemphigoid-is-mostly-associated-with-disease-severity-and-to-absence-of-anti-bp230-autoantibody
#2
Ariane Clapé, Céline Muller, Grégory Gatouillat, Sébastien Le Jan, Coralie Barbe, Bach-Nga Pham, Frank Antonicelli, Philippe Bernard
Bullous pemphigoid (BP) is the most common autoimmune bullous disease and typically affects the elderly. Binding of specific autoantibodies to BP180/230 hemidesmosomal components induces an inflammatory response leading to skin blister formation. Unusual manifestations of BP include additional mucous membrane involvement, without pathophysiological knowledge associated to the formation of these lesions. We here performed a prospective study on series of consecutive BP patients with ( n  = 77) and without ( n  = 18) mucosal involvements at baseline to further investigate why some BP patients display mucosal lesion and other not...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29619029/anti-type-vii-collagen-antibodies-are-identified-in-a-subpopulation-of-bullous-pemphigoid-patients-with-relapse
#3
Delphine Giusti, Grégory Gatouillat, Sébastien Le Jan, Julie Plée, Philippe Bernard, Frank Antonicelli, Bach-Nga Pham
Bullous pemphigoid (BP) is an autoimmune bullous skin disease characterized by anti-BP180 and anti-BP230 autoantibodies (AAbs). Mucous membrane involvement is an uncommon clinical feature of BP which may evoke epidermolysis bullosa acquisita, another skin autoimmune disease characterized by anti-type VII collagen AAbs. We therefore evaluated the presence of anti-type VII collagen AAbs in the serum of BP patients with and without mucosal lesions at time of diagnosis and under therapy. Anti-BP180, anti-BP230, and anti-type VII collagen AAbs were measured by ELISA in the serum of unselected patients fulfilling clinical and histo/immunopathological BP criteria at baseline ( n  = 71) and at time of relapse ( n  = 24)...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29607480/prospective-study-in-bullous-pemphigoid-association-of-high-serum-anti-bp180-igg-levels-with-increased-mortality-and-reduced-karnofsky-score
#4
M M Holtsche, S Goletz, N van Beek, D Zillikens, S Benoit, K Harman, S Walton, J English, M Sticherling, A Chapman, N J Levell, R Groves, H C Williams, I R König, E Schmidt
BACKGROUND: Bullous pemphigoid (BP) is a subepidermal blistering disease characterized by autoantibodies against the two hemidesmosomal proteins BP180 (type XVII collagen) and BP230. The multicenter prospective BLISTER (Bullous Pemphigoid Steroids and Tetracyclines) trial randomized 253 BP patients to compare the benefits and harms between initial treatment with doxycycline or prednisolone. OBJECTIVES: To analyze distinct autoantibody profiles for the prediction of the disease course in a well characterized cohort of BP sera...
April 1, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29545809/the-autoimmune-skin-disease-bullous-pemphigoid-the-role-of-mast-cells-in-autoantibody-induced-tissue-injury
#5
REVIEW
Hui Fang, Yang Zhang, Ning Li, Gang Wang, Zhi Liu
Bullous pemphigoid (BP) is an autoimmune and inflammatory skin disease associated with subepidermal blistering and autoantibodies directed against the hemidesmosomal components BP180 and BP230. Animal models of BP were developed by passively transferring anti-BP180 IgG into mice, which recapitulates the key features of human BP. By using these in vivo model systems, key cellular and molecular events leading to the BP disease phenotype are identified, including binding of pathogenic IgG to its target, complement activation of the classical pathway, mast cell degranulation, and infiltration and activation of neutrophils...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29502439/dyshidrotic-bullous-pemphigoid-case-report-and-review-of-literature
#6
Sana Basseri, Thai Yen Ly, Peter R Hull
BACKGROUND: Dyshidrotic pemphigoid (DP) is a rare variant of bullous pemphigoid (BP) that affects the hands and feet and may resemble an acute vesicular eczema. While it can remain confined to hands and feet, spread that involves the entire body is described. BP and DP are associated with autoantibodies directed against hemidesmosomal proteins BP180 (collagen XVII) and BP230 (dystonin), which are transmembrane and intracellular proteins in the basement membrane zone, respectively. CASE SUMMARY: We present a case of DP in a 78-year-old woman who was diagnosed based on histopathologic and immunofluorescence findings and subsequently successfully treated...
March 1, 2018: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29473148/a-subset-of-patients-with-pemphigoid-herpes-gestationis-has-serological-evidence-of-celiac-disease
#7
Hedieh Saffari, John J Zone, Marjorie Allen, Kristin M Leiferman
BACKGROUND: Pemphigoid (herpes) gestationis (PG) is an uncommon, self-limited disease with other autoimmune associations; however, celiac disease (CD) is not recognized as one. METHODS: From 71 patients' sera submitted for herpes gestationis factor (HGF) testing over a 5-year period, 12 were consistent with PG demonstrating HGF and increased IgG BP180 antibody levels; these sera were tested for IgA and IgG endomysial antibodies (EMA), epithelial basement membrane zone and cell surface antibodies by indirect immunofluorescence, and for IgA and IgG tissue transglutaminase (transglutaminase 2 or TG2) antibodies, IgA epidermal transglutaminase (transglutaminase 3 or TG3) antibodies, IgG BP230, and IgG desmoglein 1 and desmoglein 3 antibodies by enzyme-linked immunosorbent assays (ELISAs)...
February 23, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29423547/bpdai-and-absis-correlate-with-serum-anti-bp180-nc16a-igg-but-not-with-anti-bp230-igg-in-patients-with-bullous-pemphigoid
#8
Maryam Daneshpazhooh, Maryam Ghiasi, Vahideh Lajevardi, Nafise Nasiri, Kamran Balighi, Amir Teimourpour, Hasan Khosravi, Vahide Saeidi, Hamidreza Mahmoudi, Cheyda Chams-Davatchi
Bullous pemphigoid (BP) is an autoimmune bullous disease characterized by autoantibody production against BP180 and BP230. Two scoring systems have been validated for BP including: Bullous Pemphigoid Disease Area Index (BPDAI) and Autoimmune Bullous Skin Disorder Intensity Score (ABSIS). In this study, we investigated correlations between both scoring systems and either anti-BP180 NC16A or anti-BP230 values. BPDAI and ABSIS were used to measure disease activity in 95 BP patients at Razi Hospital in Tehran, Iran...
February 8, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29411416/decrease-in-eosinophils-infiltrating-into-the-skin-of-patients-with-dipeptidyl-peptidase-4-inhibitor-related-bullous-pemphigoid
#9
Chika Chijiwa, Shintaro Takeoka, Masahiro Kamata, Mihoko Tateishi, Saki Fukaya, Kotaro Hayashi, Atsuko Fukuyasu, Takamitsu Tanaka, Takeko Ishikawa, Takamitsu Ohnishi, Shinichi Watanabe, Yayoi Tada
Bullous pemphigoid (BP) is an acquired autoimmune blistering disease in which autoantibodies against epitopes in the basement membrane zone of the skin such as BP180 or BP230 are produced. Dipeptidyl peptidase (DPP)-4 inhibitors have become commonly used to treat diabetes. As DPP-4 inhibitors are more commonly prescribed for diabetes, BP related to DPP-4 inhibitors has been reported and has attracted attention. Therefore, we retrospectively investigated patients who were diagnosed with BP in order to examine characteristics of DPP-4 inhibitor-related BP (nine patients; median age, 85 years) in comparison with non-DPP-4 inhibitor-related BP (21; median age, 85 years)...
February 6, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/29378676/a-case-of-bullous-pemphigoid-with-igg-antibodies-against-lad-1-but-not-bp180-nc16a-domain-or-bp230
#10
Kazuya Miyashita, Hiroshi Iioka, Fumi Miyagawa, Norito Ishii, Takashi Hashimoto, Hideo Asada
No abstract text is available yet for this article.
January 29, 2018: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29336324/diagnostic-value-of-autoantibody-titres-in-patients-with-bullous-pemphigoid
#11
Julia Eckardt, Franziska C Eberle, Kamran Ghoreschi
BACKGROUND: Bullous pemphigoid (BP) is the most common autoimmune blistering disease of the skin requiring skin and serum tests for a precise diagnosis. OBJECTIVES: We analysed the sensitivity and specificity of BP-relevant parameters and the value of autoantibody titres during follow-up of BP patients. MATERIALS & METHODS: In a retrospective single-centre study, we included 200 consecutive patients with BP and 400 non-BP patients, and evaluated the test results of patients' serum and skin...
February 1, 2018: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29299596/clinical-and-immunological-profiles-of-14-patients-with-bullous-pemphigoid-without-igg-autoantibodies-to-the-bp180-nc16a-domain
#12
Kenta Nakama, Hiroshi Koga, Norito Ishii, Chika Ohata, Takashi Hashimoto, Takekuni Nakama
Importance: Enzyme-linked immunosorbent assay (ELISA) and/or chemiluminescent enzyme immunoassay (CLEIA) for BP180 noncollagenous 16A (NC16A) extracellular domain is a sensitive diagnostic tool for bullous pemphigoid (BP). However, some patients with BP have negative results for these assays. Objective: To elucidate the clinical and immunological features of patients with BP without antibodies that react to BP180 NC16A. Design, Setting, and Participants: This retrospective case series study included 152 patients who were diagnosed with BP and followed up at the Kurume University Hospital in Japan from 2007 to 2016...
March 1, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/29159879/new-insights-into-pemphigoid-diseases
#13
EDITORIAL
Frank Antonicelli, Ralf J Ludwig
No abstract text is available yet for this article.
December 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/29105148/biomarkers-related-to-bullous-pemphigoid-activity-and-outcome
#14
REVIEW
Delphine Giusti, Sébastien Le Jan, Gregory Gatouillat, Philippe Bernard, Bach Nga Pham, Frank Antonicelli
Bullous pemphigoid (BP) is the most common autoimmune subepidermal blistering disease of the skin. Investigation of the BP-associated pathophysiological processes during the last decades showed that the generation of autoantibodies directed against the hemidesmosome proteins BP180 and BP230, a hallmark of the BP-associated autoimmune response, leads to the recruitment of inflammatory immune cells at the dermal-epidermal junction, and subsequently to the release of a large amount of inflammatory molecules involved in blister formation...
December 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/29054606/semaphorin-4d-from-cd15-granulocytes-via-adam10-induced-cleavage-contributes-to-antibody-production-in-bullous-pemphigoid
#15
Shengxian Shen, Yao Ke, Erle Dang, Hui Fang, Yuqian Chang, Jieyu Zhang, Zhenlai Zhu, Shuai Shao, Pei Qiao, Tongmei Zhang, Hongjiang Qiao, Gang Wang
Autoreactive B cells activation and antibody production are critical events for the development of bullous pemphigoid (BP). However, the mechanism that is involved in the modulation of B cell activation and autoantibody generation has not been fully understood. Semaphorin 4D (Sema4D/CD100) plays important roles in immune regulation related to B cell, but its implication in BP remains obscure. The aim of our study was to characterize Sema4D and the underlying mechanism contributing to the autoimmune features of BP...
October 17, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29025244/a-comparative-study-of-expression-of-fc-receptors-in-relation-to-the-autoantibody-mediated-immune-response-and-neutrophil-elastase-expression-in-autoimmune-blistering-dermatoses
#16
COMPARATIVE STUDY
Justyna Gornowicz-Porowska, Agnieszka Seraszek-Jaros, Monika Bowszyc-Dmochowska, Elżbieta Kaczmarek, Paweł Pietkiewicz, Paweł Bartkiewicz, Marian Dmochowski
Here we investigated the cutaneous CD32A and CD89 expression in relation to the neutrophil elastase (NE) expression and serum level of anti-desmoglein 1 and 3 (DSG1/DSG3) IgG in pemphigus, anti-BP180/BP230 IgG in bullous pemphigoid (BP), anti-gliadin nonapeptides (npG), tissue (tTG), and epidermal transglutaminases (eTG) IgA in dermatitis herpetiformis (DH). The examined material consisted of skin/mucosal tissues and sera. In total, 87 patients were studied. Immunohistochemistry on paraffin-embedded sections with quantitative digital morphometry was used to measure the intensity of CD32A/CD89/NE expressions...
2017: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/28948640/clinical-evaluation-of-a-multiparametric-elisa-as-a-rapid-tool-for-routinely-diagnosing-igg-mediated-autoimmune-blistering-dermatoses-in-ethnic-slavs
#17
Justyna Gornowicz-Porowska, Agnieszka Seraszek-Jaros, Monika Bowszyc-Dmochowska, Paweł Bartkiewicz, Elżbieta Kaczmarek, Marian Dmochowski
BACKGROUND: Technical innovation of autoimmune blistering dermatoses (ABDs) diagnosis aimed at multiplex approach. Two multiparametric ELISA tests are commercially available for ABDs serology. The aim was to compare diagnostic accuracy of multiparametric and monospecific ELISAs and to examine the diagnostic value/agreement of multivariant ELISA in compliance with traditional diagnostic setup for ABDs. METHODS: In total, 128 sera from suspected ABDs patients were studied (27 sera in order to compare ELISAs)...
September 26, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28887824/structural-proteins-of-the-dermal-epidermal-junction-targeted-by-autoantibodies-in-pemphigoid-diseases
#18
REVIEW
Stephanie Goletz, Detlef Zillikens, Enno Schmidt
The dermal-epidermal junction consists of a network of several interacting structural proteins that strengthen adhesion and mediate signalling events. This structural network consists of hemidesmosomal-anchoring filament complexes connecting the basal keratinocytes to the basement membrane. The anchoring filaments in turn interact with the anchoring fibrils to attach the basement membrane to the underlying dermis. Several of these structural proteins are recognized by autoantibodies in pemphigoid diseases, a heterogeneous group of clinically and immunopathologically diverse entities...
December 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28868796/ige-autoreactivity-in-bullous-pemphigoid-eosinophils-and-mast-cells-as-major-targets-of-pathogenic-immune-reactants
#19
P C Freire, C H Muñoz, G Stingl
BACKGROUND: Bullous pemphigoid (BP) is an autoimmune disease characterized by tense blisters that are usually preceded by urticarial eruptions. Affected patients exhibit IgG and/or IgE autoantibodies against BP180 and/or BP230. Their relative importance in disease pathogenesis has not been fully elucidated. OBJECTIVES: The aim of this study was to provide a better characterization of the circulating and tissue-resident IgE in patients with BP at the serological, structural and functional levels...
December 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28833620/eosinophils-as-putative-therapeutic-targets-in-bullous-pemphigoid
#20
REVIEW
Dagmar Simon, Luca Borradori, Hans-Uwe Simon
Bullous pemphigoid (BP) is the most common autoimmune subepidermal blistering skin disease and is characterized by the presence of autoantibodies directed against the hemidesmosomal proteins BP180 and BP230 that can be detected in the skin and serum of BP patients. Histologically, the dermal infiltration of eosinophils is obvious. The objective of this review was to present evidence that eosinophils play a key role in the pathogenesis of BP. Eosinophils, together with cytokines and chemokines regulating their production, recruitment and activation, are abundantly present in lesional skin, in blisters and in peripheral blood of patients with BP...
December 2017: Experimental Dermatology
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